CN218629845U

CN218629845U - Automatic uncovering and sample adding device suitable for single-molecule POCT equipment and single-molecule POCT equipment comprising same

Info

Publication number: CN218629845U
Application number: CN202222761978.2U
Authority: CN
Inventors: 黄一鸣; 朱文超; 董杰
Original assignee: Suzhou Yuce Biotechnology Co ltd
Current assignee: Suzhou Yuce Biotechnology Co ltd
Priority date: 2022-10-20
Filing date: 2022-10-20
Publication date: 2023-03-14
Anticipated expiration: 2032-10-20

Abstract

The application relates to an automatic sample adding device that uncaps suitable for unimolecule POCT equipment and unimolecule POCT equipment that contains it, the automatic sample adding device that uncaps contains and gets lid subassembly, sample application of sample subassembly and reagent application of sample subassembly. This application is through with above-mentioned three kinds of subassemblies integration in same mounting substrate to can realize uncapping, the application of sample action in less space, realize the compactification of equipment. The automatic sample adding device with the cover being opened is specially designed for the single-molecule POCT equipment, and can fully meet the requirements of portability and rapid diagnosis required by the POCT equipment.

Description

Automatic uncovering and sample adding device suitable for single-molecule POCT equipment and single-molecule POCT equipment comprising same

Technical Field

The application relates to medical equipment, in particular to an automatic uncovering sample adding device suitable for single-molecule POCT equipment and the single-molecule POCT equipment comprising the same.

Background

Point of care testing (POCT), also known as on-site rapid diagnosis and bedside diagnosis, has the characteristics of convenient use and wide application range with the development of immunological techniques and molecular biotechnology, and is continuously concerned and valued by people in new fields of inspection medicine. In recent years, to meet the demand for hypersensitivity detection, single-molecule immunoassay methods have been developed. However, no POCT device for single molecule immunoassay has been developed.

In the current immunoassay analyzer, most samples are loaded in test tubes, and the test tube covers need to be opened preferentially when the sample needles are used for sampling. Most of automatic uncovering devices and sample adding devices of currently marketed immunoassay analyzers (see patent document 1~3) are separately and independently arranged in different areas and work under the driving of independent moving mechanisms to ensure the accuracy of an uncovering process, a sampling process and a reagent adding process, but the working mode has large space requirement, so that the volume of the equipment is inevitably increased, and the equipment cannot be applied to POCT equipment.

Documents of the prior art

Patent document 1: CN208795750U;

patent document 2: CN104444983A;

patent document 3: CN111856047A.

Disclosure of Invention

In view of the above problems, an object of the present application is to provide an automatic uncovering sample adding device suitable for a single-molecule POCT apparatus, which can effectively reduce the module volume, has a simple and compact structure, and a single-molecule POCT apparatus including the same.

The present application includes the following technical solutions.

In a first aspect, the application relates to an automatic uncovering sample adding device suitable for single-molecule POCT equipment, which comprises a sample adding component, a sample adding component and a reagent adding component which are arranged on the same mounting substrate,

the cover taking component and the sample adding component are arranged on the same side of the mounting substrate and share a Y-axis movement mechanism to move in the Y-axis direction, namely the horizontal direction, the reagent adding component is arranged on the other side of the mounting substrate,

the mounting substrate is in a cuboid shape, two Y-axis motion mechanisms are respectively mounted on the surfaces of two sides of the mounting substrate,

the sample loading assembly and the reagent loading assembly both comprise a sample needle, a Z-axis movement mechanism, an anti-collision mechanism and a liquid level detection mechanism.

In one embodiment, the two Y-axis motion mechanisms each include a stepping motor, a linear guide, and a timing belt, and the stepping motors included in the two Y-axis motion mechanisms are mounted on the same side as the reagent sample loading assembly and are vertically disposed on the mounting substrate.

In one embodiment, the anti-collision mechanism comprises an anti-collision optocoupler, a spring, an anti-collision baffle and an anti-collision rod,

the spring is sleeved on the anti-collision rod,

the front end of the anti-collision baffle is connected with the anti-collision rod and is positioned in the anti-collision optocoupler, and the front end of the anti-collision baffle protrudes out of the anti-collision optocoupler when the sample needle collides,

the anti-collision optocoupler is arranged on the liquid level detection mechanism.

In one embodiment, the Z-axis movement mechanism comprises a stepping motor, a synchronous belt, a driving wheel, a driven wheel, a single linear guide rail and a Z-axis zero-position optical coupler.

In one embodiment, the cover taking assembly comprises a cover taking module, a fixing module and an L-shaped mounting plate, the cover taking module is connected with a vertical plate of the L-shaped mounting plate, the fixing module is connected with a horizontal plate of the L-shaped mounting plate,

the cover taking module comprises two cover taking clamping hands, a cover taking motor, a Z-axis lead screw motor and a slide rail connecting piece, the cover taking clamping hands are positioned below the cover taking motor, the cover taking motor is connected with the Z-axis lead screw motor through the slide rail connecting piece,

the fixed module comprises two fixed clamping hands, an X-axis lead screw motor, an X-axis linear guide rail and a fixed clamping hand opening and closing motor, the fixed clamping hands are directly connected with the fixed clamping hand opening and closing motor, the fixed clamping hand opening and closing motor is connected with the X-axis lead screw motor through a connecting piece, and the X-axis linear guide rail is arranged on the upper portion of the X-axis lead screw motor.

In one embodiment, the cover taking motor is used for opening and closing and rotating the cover taking clamping hands, the Z-axis lead screw motor is used for moving the cover taking module in the Z-axis direction, namely the vertical direction, the X-axis lead screw motor is used for moving the fixed clamping hands in the X-axis direction, namely the horizontal direction, and the fixed clamping hand opening and closing motor is used for opening and closing the fixed clamping hands.

In one embodiment, a hole for a screw rod of a Z-axis screw rod motor to pass through is formed in the center of the bottom of a transverse plate of the L-shaped mounting plate.

In one embodiment, the inner sides of the two cover taking clamping hands are provided with arc-shaped grooves matched with the test tube covers, and the inner sides of the two fixing clamping hands are smooth and are not provided with the arc-shaped grooves.

In one embodiment, the X-axis lead screw motor drives the fixed gripper opening and closing motor to move back and forth in the X-axis direction via the X-axis linear guide rail and the connecting member, so that the fixed gripper moves back and forth in the X-axis direction.

In the above-mentioned automatic application of sample device that uncaps that is applicable to single molecule POCT equipment, the lid subassembly will be got for the first time, sample application of sample subassembly and reagent application of sample subassembly set up on same mounting substrate, make in addition get the lid subassembly and sample application of sample subassembly and use same Y axle motion, still set up the part of each subassembly in the suitable position of mounting substrate's both sides, thereby can realize uncapping, the application of sample action in limited space, make equipment more compact under the circumstances of guaranteeing basic function, can suitably be used for single molecule POCT equipment.

In another aspect, the application relates to a single-molecule POCT apparatus comprising any one of the above auto-uncapped sample addition devices.

Compared with the prior art, the application can obtain the following excellent effects:

(1) Through the specific structure of the automatic uncovering sample adding device, particularly, the cover taking component, the sample adding component and the reagent adding component are arranged on two sides of the same mounting substrate, the cover taking component and the sample adding component are combined by the same Y-axis movement mechanism and the like, so that the whole volume of the module can be controlled in a range as small as possible under the condition of ensuring basic functions, the device is more compact, and the automatic uncovering sample adding device is well suitable for single-molecule POCT equipment;

(2) The number of required driving devices is less, and the cost is reduced;

(3) By the automatic uncovering sample adding device, a test tube cover can be put back after a test tube is sampled, waste collection and treatment are not needed, space and time are greatly saved, and cost is reduced;

(4) In the preferred scheme, the volume of each component is compact, and the reduction of the volume of the equipment is further realized.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are required to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present application and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained from the drawings without inventive effort.

Fig. 1 is a perspective view of the automatic lid-opening sample application device according to the present application, viewed from one side of a lid application assembly.

Fig. 2 is a perspective view of the automatic lid-opening sample application device of the present application, viewed from one side of the reagent sample application assembly.

Fig. 3 is a top view of an automatic lid opening sample adding device of the present application.

Fig. 4 is a perspective view of the cap removal assembly of the present application.

Fig. 5 is a front view of the cap remover assembly of the present application.

Fig. 6 is a perspective view of a sample application assembly of the present application.

FIG. 7 is a perspective view of a reagent loading assembly of the present application.

Reference numerals: 1-taking the cover component; 2-sample application component; 3-a reagent sample addition component; 4-a mounting substrate;

51-a stepper motor; 52-linear guide rail; 53-synchronous belt; 54-a stepper motor; 55-linear guide rail; 56-synchronous belt;

11-cover taking module; 12-a stationary module; 13-L-shaped mounting plates; 111. 112-cover taking clamping hands; 113-a cover taking motor; a 114-Z axis lead screw motor; 1141-a screw rod; 115-a sliding track connection; 121. 122-fixed gripper; a 123-X axis screw motor; 124-X axis linear guide; 125-fixed gripper opening and closing motor; 126-a connector; the vertical plate of the 131-L-shaped mounting plate 13 and the transverse plate of the 132-L-shaped mounting plate 13;

21-a sample needle; a 22-Z axis motion mechanism; 23-a collision avoidance mechanism; 24-liquid level detection means; a 25-L shaped mounting plate; 221-a stepper motor; 222-a synchronous belt; 223-driving wheel; 224-a driven wheel; 225-single linear guide; 231-anti-collision optocoupler; 232-a spring; 233-crashproof catch; 234-crash bar;

31-a reagent needle; a 32-Z axis motion mechanism; 33-a collision avoidance mechanism; 34-liquid level detection means; 321-a stepping motor; 322-Z axis zero optical coupler; 331-an anti-collision optical coupler; 332-a spring; 333-anti-collision baffle sheet; 334-crash bar.

Detailed Description

Furthermore, the terms "horizontal", "vertical", "overhang" and the like do not imply that the components are required to be absolutely horizontal or overhang, but may be slightly inclined. For example, "horizontal" merely means that the direction is more horizontal than "vertical" and does not mean that the structure must be perfectly horizontal, but may be slightly inclined.

In the description of the present application, it should be noted that the terms "inside", "outside", "left", "right", "upper", "lower", and the like indicate orientations or positional relationships based on orientations or positional relationships shown in the drawings or orientations or positional relationships that are usually placed when products of the application are used, and are only used for convenience of description and simplification of the description, but do not indicate or imply that the devices or elements referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present application.

In the description of the present application, unless expressly stated or limited otherwise, the terms "disposed," "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements.

The technical solution of the present application will be clearly and completely described below with reference to the accompanying drawings.

Fig. 1 is a perspective view of the automatic lid-opening sample application device according to the present application, viewed from one side of a lid application assembly. The automatic uncapping sample adding device comprises a sample adding assembly 1, a sample adding assembly 2 and a reagent adding assembly 3 which are arranged on the same mounting substrate 4. In fig. 1, a cap assembly 1 and a sample application assembly 2 are mounted on the same side of a mounting substrate 4 and share a Y-axis movement mechanism, and both move in the Y-axis direction, i.e., the horizontal direction, and the cap assembly 1 and the sample application assembly 2 are arranged side by side along the Y-axis. On the other hand, the reagent loading unit 3 is mounted on the other side (the back side in fig. 1) of the mounting substrate 4. The mounting substrate 4 is in a rectangular parallelepiped shape, and two Y-axis movement mechanisms are respectively mounted on the surfaces of two sides of the mounting substrate, each of the two Y-axis movement mechanisms comprises a stepping motor, a linear guide rail and a synchronous belt, and can further comprise a zero-position optical coupler located at one end of the synchronous belt so as to well position each component. The cover member 1 and the sample application member 2 may be connected to the Y-axis movement mechanism by various connection means known in the art, and are not particularly limited. In fig. 1, a sample application assembly 2 is fixed on a Y-axis movement mechanism through a slider, and the application assembly is connected with the slider through a connecting member.

As shown in fig. 1, reference numeral 51 is a stepping motor for moving the cover taking assembly 1 and the sample adding assembly 2 in the Y-axis direction, reference numeral 52 is a linear guide for moving the cover taking assembly 1 and the sample adding assembly 2 in the Y-axis direction, and reference numeral 53 is a timing belt for moving the cover taking assembly 1 and the sample adding assembly 2 in the Y-axis direction. The linear guide rollers 52 are vertically disposed, and the timing belt 53 passes through the middle of the two linear guide rollers.

In fig. 1, the stepping motor 51, the linear guide 52, and the timing belt 53 are all provided at the middle-lower portion of the mounting substrate 1, but the present invention is not limited thereto, and they may be provided at the middle-upper portion of the mounting substrate 1. In view of shortening the movement distance of the cap assembly 1 and the sample application assembly 2 in the Z-axis direction as much as possible and improving the detection rate, the stepping motor 51, the linear guide 52, and the timing belt 53 are preferably provided at the middle-lower portion of the mounting substrate 1.

The cap taking component 1 and the sample adding component 2 share the same set of Y-axis motion mechanism including the stepping motor 51, the linear guide 52 and the synchronous belt 53, thereby reducing the number of driving mechanisms, making the apparatus more compact and reducing the cost.

Fig. 2 is a perspective view of the automatic lid-opening sample application device of the present application, viewed from one side of the reagent sample application assembly. As shown in fig. 2, the reagent loading assembly 3 is provided on a side of the mounting substrate 1 different from the loading assembly. Two stepping

motors

51 and 54 are arranged at one end in the Y-axis direction, wherein the stepping motor 51 is a driving source in a Y-axis movement mechanism shared by the sample taking and adding assembly 1 and the sample adding assembly 2, the stepping motor 54 is a driving source in a Y-axis movement mechanism corresponding to the reagent adding assembly 3, and the stepping motor 51 is arranged below the stepping motor 54. The Y-axis movement mechanism for driving the reagent sample adding assembly 3 to move in the Y-axis direction also comprises a stepping motor 54, a linear guide 55 and a synchronous belt 56, and compared with the Y-axis movement mechanism shared by the sample adding assembly 2 and the sample obtaining assembly 1, the Y-axis movement mechanism for driving the reagent sample adding assembly 3 to move in the Y-axis direction is arranged at the middle upper part. Through the arrangement, the cover taking component 1, the sample adding component 2, the reagent adding component 3 and the driving mechanisms thereof can be skillfully arranged on one mounting substrate, so that the volume of the device is greatly reduced while respective basic functions are realized, and the equipment is more compact. In addition, a zero position optical coupler can be arranged at the other end (the side opposite to the end where the stepping motor is positioned) in the Y-axis direction so as to achieve better positioning.

Fig. 3 is a top view of the automatic uncovering sample adding device of the present application. As shown in fig. 3, the cover taking assembly 1 and the sample adding assembly 2 are disposed on the left side of the mounting substrate 1, the reagent adding assembly 3 is disposed on the right side of the mounting substrate 1, and the stepping

motors

51 and 54 of the two Y-axis movement mechanisms are disposed at one end portion of the right side of the mounting substrate 1. The cover taking component 1 and the sample adding component 2 can be connected together through the Z-axis mounting substrate and the connecting block of the cover taking component 1, and move together in the Y-axis direction, but the invention is not limited thereto.

The manner in which the cover assembly 1, the sample addition assembly 2, the reagent addition assembly 3, and their driving mechanisms are mounted on the mounting substrate has been described above. The specific structure of each component is explained below.

Fig. 4 is a perspective view of the cover taking assembly 1 of the present application, including the cover taking module 11, the fixing module 12 and the L-shaped mounting plate 13, the cover taking module 11 includes two cover taking clamping hands 111 and 112 (shown in fig. 5), a cover taking motor 113, a Z-axis screw motor 114 and a sliding rail connector 115, and the fixing module 2 includes two fixing clamping hands 121 and 122, an X-axis screw motor 123, an X-axis linear guide 124 (shown in fig. 5) and a fixing clamping hand opening and closing motor 125. The cover removing module 11 is connected with a vertical plate 131 of the L-shaped mounting plate 13, and the fixing module 12 is connected with a horizontal plate 132 of the L-shaped mounting plate 13.

The cover taking clamping

hands

111 and 112 are positioned below a cover taking motor 113, and the cover taking motor 113 is connected with a Z-axis screw rod motor 114 through a slide rail connecting piece 115. The inner sides of the two cap-removing

clamping hands

111 and 112 are provided with arc-shaped grooves matched with the test tube caps, so that the test tube caps can be firmly clamped and screwed up. The cover taking motor 113 is used for opening, closing and rotating the cover taking clamp, and a pneumatic device is not used, so that the condition that the test tube clamp is damaged or the clamping force is insufficient due to unstable air pressure can be avoided. The specific structure of the slide rail connector 115 may be various as long as the cap removing motor can be slidably connected to the Z-axis screw motor 114. In this embodiment, it includes a hollow block through which the lead screw of the Z-axis lead screw motor 114 passes and a connection block directly connected to the cap removing motor 113. The hollow block is connected with the connecting block through screws. The cover-removing motor can be in various shapes, and in the embodiment, the cover-removing motor is cylindrical, so that the structure can be more compact.

The cover removing module 11 is connected to a vertical plate 131 of the L-shaped mounting plate 13, and more specifically, is slidably connected to the vertical plate 131 of the L-shaped mounting plate 13 via a slide rail at an upper portion of a cover removing motor of the cover removing module. The L-shaped mounting plate 13 is provided with a sliding rail for sliding the cover taking motor, and the topmost end of the cover taking motor 113 is approximately flush with the topmost end of the L-shaped mounting plate 13, so that the structure is more compact.

The uppermost end of the lead screw 1141 of the Z-axis lead screw motor 114 may be slightly lower than the uppermost end of the cap removing motor 113, so as to consider the maximum moving distance and the cost in the Z-axis direction. The lead screw 1141 of the Z-axis lead screw motor 114 passes through the central hole of the transverse plate 132 of the L-shaped mounting plate 13, and the motor part of the Z-axis lead screw motor 114 is arranged below the transverse plate 132 of the L-shaped mounting plate 13 and is arranged adjacent to the X-axis lead screw motor 123 of the fixed module 12. Make to get the lid tong up-and-down motion through setting up Z axle lead screw motor 114, can adjust the height of getting the lid tong, space utilization is high, is applicable to the not sample test tube of co-altitude, satisfies the condition that detection and analysis equipment needs height, low test tube simultaneous use among the prior art, has greatly increased the application scope of whole POCT equipment, has effectively solved sample and test tube collocation problem among the prior art.

To better illustrate the structure of the fixed module 12, the following description is provided with reference to fig. 5. Fig. 5 is a front view of the test tube uncapping apparatus. The fixed module 12 mainly includes two fixed clamping hands 121 and 122, an X-axis lead screw motor 123, an X-axis linear guide rail 124, and a fixed clamping hand opening and closing motor 125. The fixing module 12 is disposed below the transverse plate of the L-shaped mounting plate via a connecting member, and is sequentially provided with an X-axis linear guide rail 124, an X-axis screw motor 123, a fixing clamp opening and closing motor 125, and two fixing clamps 121 and 122 from top to bottom, wherein the two fixing clamps 121 and 122 are located right below a motor portion of the X-axis screw motor 123.

The X-axis linear guide 124 is connected to the transverse plate of the L-shaped mounting plate via a connecting member, and is disposed above the X-axis screw motor 123. The X-axis lead screw motor 123 drives the fixed gripper opening and closing motor 125 to horizontally move in the X-axis direction by means of the X-axis linear guide and another connecting member 126 (a connecting member connecting the X-axis lead screw motor 123 and the fixed gripper opening and closing motor 125), thereby driving the fixed grippers 121 and 122 connected to the fixed gripper opening and closing motor 125 to horizontally move in the X-axis direction.

The fixed gripper opening and closing motor 125 is used to open and close the fixed grippers 121 and 122, and has a substantially cylindrical shape. The fixing clamping hands 121 and 122 are completely the same, the cross sections are in a step shape, the inner sides of the two fixing clamping hands are smooth, and arc-shaped grooves are not formed.

Hereinafter, a specific flow of removing the cap will be described by way of example.

During sample adding, the sample rack is transferred into the sample dispatching trolley assembly from the sample bin, and after the sample tube is completely scanned, the sample tube reaches the designated sampling position and stops. The fixing clamp opening and closing motor 125 of the fixing module 12 separates the fixing clamps 121 and 122, the X-axis lead screw motor 123 moves the fixing clamps 121 and 122 to the test tube position by means of the X-axis linear guide rail and the connecting piece, and the two clamps are closed to complete the test tube fixing action. Then the cover taking clamping

hands

111 and 112 are opened under the action of the cover taking motor 113, and the cover taking clamping

hands

111 and 112 are moved to the cover part of the sample test tube through the cooperative motion among the Z-axis lead screw motor, the slide rail connecting piece and other connecting pieces, and the two cover taking clamping hands are closed. After the test tube cap is clamped, the cap taking motor 113 enables the two cap taking clamping hands to rotate, and under the action of the Z-axis lead screw motor, the cap taking motor 113 and the two cap taking clamping hands ascend together to take down the test tube cap, and the cap taking action is completed. After a certain sample test tube is sampled, the cap-taking clamp can continuously put back the test tube cap to the test tube cap without the need of processing the cap throwing and waste collecting, thereby saving space and reducing the possibility of biological pollution.

Fig. 6 is a perspective view of the sample application assembly 2 of the present application, which includes a sample needle 21, a Z-axis movement mechanism 22, a collision prevention mechanism 23, and a liquid level detection mechanism 24. The Z-axis movement mechanism 22 includes a stepping motor 221, a timing belt 222, a driving wheel 223, a driven wheel 224, a single linear guide track 225, and a Z-axis zero optical coupler (not shown, which may be located at the uppermost end).

The anti-collision mechanism 23 comprises an anti-collision optocoupler 231, a spring 232, an anti-collision baffle 233 and an anti-collision rod 234, wherein the spring 232 is sleeved on the anti-collision rod 234, the anti-collision baffle 233 is connected with the anti-collision rod 234, the front end of the anti-collision baffle 233 is arranged in the anti-collision optocoupler 231, and when the sample needle 21 collides, the front end of the anti-collision baffle 233 protrudes out of the anti-collision optocoupler 231, so that the anti-collision optocoupler 231 senses a signal and gives an alarm. The anti-collision optocoupler 231 may be disposed on a circuit board of the liquid level detection mechanism 24 to make the structure compact.

The liquid level detection mechanism 24 and the anti-collision mechanism 23 are arranged on the same L-shaped mounting plate 25, and the liquid level detection mechanism 24 is arranged above the anti-collision mechanism 23. The L-shaped mounting plate 25 is connected to a single linear guide 225 of the Z-axis moving mechanism 22 via a slider. The sample needle 21 is disposed below the L-shaped mounting plate to suck and add a sample.

Fig. 7 is a perspective view of the reagent loading assembly 3 according to the present invention, which is substantially the same as the components of the sample loading assembly 2, and includes a reagent needle 31, a Z-axis movement mechanism 32, a collision prevention mechanism 33, and a liquid level detection mechanism 34. The Z-axis movement mechanism 32 also includes a stepping motor 321, a timing belt (on the back, not shown), a driving wheel (on the back, not shown), a driven wheel (on the back, not shown), a single linear guide rail (on the back, not shown), and a Z-axis zero position optical coupler 322.

The anti-collision mechanism 33 comprises an anti-collision optical coupler 331, a spring 332, an anti-collision blocking piece 333 and an anti-collision rod 334, wherein the spring 332 is sleeved on the anti-collision rod 334, the anti-collision blocking piece 333 is connected with the anti-collision rod 334, the front end of the anti-collision blocking piece 333 is arranged in the anti-collision optical coupler 331, and when the reagent needle 31 collides, the front end of the anti-collision blocking piece 333 protrudes out of the anti-collision optical coupler 331, so that the anti-collision optical coupler 331 senses a signal and gives an alarm. The bump optical coupler 331 may be disposed on a circuit board of the liquid level detection mechanism 34 to make the structure compact.

The following is a brief description of the overall operation flow of the automatic uncovering sample adding device.

When the test tube reaches appointed application of sample position, two fixed tong 121 and 122 of subassembly that uncaps open, send two fixed tong to test tube department through X axle lead screw motor 123, fixed tong is closed and presss from both sides tight test tube. Then, two cover taking clamping

hands

111 and 112 of the cover opening assembly are opened, the Z-axis lead screw motor 114 descends to the position of the test tube cover, the cover taking clamping hands rotate while clamping, and the Z-axis lead screw motor drives the cover taking clamping hands to ascend, so that the test tube cover is opened. Next, the sample needle 21 of the sample application module 2 is moved to the test tube by the drive of the Y-axis movement mechanism, and the sample needle 21 is lowered by the drive of the Z-axis movement mechanism to perform sampling. After sampling, adding the sample into an empty reaction cup in the incubation bin, and waiting for adding the reagent to perform a mixing reaction. On the other hand, the reagent loading assembly 3 moves to the sampling port of the reagent chamber, the reagent needle 31 descends to sample under the drive of the Z-axis movement mechanism, and then moves to the reagent loading position of the incubation chamber under the drive of the Y-axis movement mechanism, and reagent is loaded into the reaction cup with the sample loaded, thereby completing reagent loading.

The above description is only a preferred embodiment of the present application and is not intended to limit the present application, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, improvement and the like made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. An automatic uncovering sample adding device suitable for single molecule POCT equipment comprises a sample adding assembly, a sample adding assembly and a reagent adding assembly which are arranged on the same mounting substrate,

the cover taking component and the sample adding component are arranged on the same side of the mounting substrate and share one Y-axis movement mechanism to move in the Y-axis direction, namely the horizontal direction, and the reagent adding component is arranged on the other side of the mounting substrate.

2. The automatic lid opening sample application device according to claim 1,

the mounting substrate is provided with a Y-axis motion mechanism on each of two side surfaces thereof

The sample loading assembly and the reagent loading assembly both comprise a sample needle, a Z-axis movement mechanism, an anti-collision mechanism and a liquid level detection mechanism,

two Y axle motion all contain step motor, linear guide and hold-in range to the step motor that two Y axle motion contained all installs in the one side the same with reagent application of sample subassembly, sets up on mounting substrate from top to bottom.

3. An automatic uncovering sample adding device according to claim 2, wherein the anti-collision mechanism comprises an anti-collision optocoupler, a spring, an anti-collision baffle and an anti-collision rod,

the spring is sleeved on the anti-collision rod,

4. An automatic uncovering sample adding device according to claim 2, wherein the Z-axis movement mechanism comprises a stepping motor, a synchronous belt, a driving wheel, a driven wheel, a single linear guide rail and a Z-axis zero-position optical coupler.

5. The automatic lid opening and sample adding device according to claim 1 or 2, wherein the lid opening and sample adding assembly comprises a lid opening and sample adding module, a fixing module and an L-shaped mounting plate, the lid opening and sample adding module is connected with a vertical plate of the L-shaped mounting plate, the fixing module is connected with a horizontal plate of the L-shaped mounting plate,

6. The automatic uncovering sample adding device according to claim 5, wherein the uncovering motor is used for opening and closing and rotating a cover taking clamping hand, the Z-axis lead screw motor is used for moving the cover taking module in the Z-axis direction, namely the vertical direction, the X-axis lead screw motor is used for moving the fixed clamping hand in the X-axis direction, namely the horizontal direction, and the fixed clamping hand opening and closing motor is used for opening and closing the fixed clamping hand.

7. The automatic uncovering sample adding device according to claim 5, wherein a hole for a screw rod of a Z-axis screw rod motor to pass through is formed in the center of the bottom of a transverse plate of the L-shaped mounting plate.

8. The automatic uncovering sample adding device according to claim 5, wherein the inner sides of the two uncovering clamping hands are provided with arc-shaped grooves matched with the test tube covers, and the inner sides of the two fixing clamping hands are smooth and are not provided with the arc-shaped grooves.

9. The automatic lid opening and sample adding device according to claim 5, wherein the X-axis screw motor drives the fixed gripper opening and closing motor to move back and forth in the X-axis direction via the X-axis linear guide and the connecting member, so that the fixed gripper moves back and forth in the X-axis direction.

10. A single molecule POCT apparatus comprising the automated decap sample loading device of any one of claims 1~9.