CN109675649A - A kind of liquid transcription device - Google Patents
A kind of liquid transcription device Download PDFInfo
- Publication number
- CN109675649A CN109675649A CN201910058734.8A CN201910058734A CN109675649A CN 109675649 A CN109675649 A CN 109675649A CN 201910058734 A CN201910058734 A CN 201910058734A CN 109675649 A CN109675649 A CN 109675649A
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- liquid
- transfering
- transfering needle
- trombone slide
- fluid
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- 239000007788 liquid Substances 0.000 title claims abstract description 105
- 238000013518 transcription Methods 0.000 title claims abstract description 31
- 230000035897 transcription Effects 0.000 title claims abstract description 31
- 230000007246 mechanism Effects 0.000 claims abstract description 79
- 239000012530 fluid Substances 0.000 claims abstract description 61
- 230000033001 locomotion Effects 0.000 claims description 19
- 238000004140 cleaning Methods 0.000 claims description 18
- 238000005192 partition Methods 0.000 claims description 10
- 230000005611 electricity Effects 0.000 claims description 3
- 239000000523 sample Substances 0.000 description 20
- 238000000605 extraction Methods 0.000 description 14
- 230000035611 feeding Effects 0.000 description 14
- 238000003825 pressing Methods 0.000 description 10
- 238000010586 diagram Methods 0.000 description 9
- 239000011324 bead Substances 0.000 description 8
- 238000000034 method Methods 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 239000002699 waste material Substances 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000002572 peristaltic effect Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 208000003556 Dry Eye Syndromes Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000011173 large scale experimental method Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000004153 renaturation Methods 0.000 description 1
- 238000011172 small scale experimental method Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 239000002351 wastewater Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
- B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
- B01L3/0231—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type having several coaxial pistons
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
- B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
- B01L3/0224—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type having mechanical means to set stroke length, e.g. movable stops
Landscapes
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention discloses a kind of liquid transcription devices, including frame, loading area, liquid-transfering device and fluid means, liquid-transfering device includes the second guide rail mechanism, liquid relief mounting rack, multichannel pipetting device and single channel pipetting device, multichannel pipetting device includes the first lifting assembly and the first liquid-transfering needle, single channel pipetting device includes the second lifting assembly and the second liquid-transfering needle, fluid means includes fluid fixed plate, multichannel pipe drawing mechanism and single channel pipe drawing mechanism, multichannel pipe drawing mechanism includes the first pushing component and the first trombone slide, single channel pipe drawing mechanism includes the second pushing component and the second trombone slide, realize the first liquid-transfering needle and the second liquid-transfering needle being separately controlled in XYZ axis, unrestricted choice carries out multichannel liquid feeding or single channel liquid feeding according to demand, the first liquid-transfering needle is connected to using the first trombone slide, second trombone slide connects Logical second liquid-transfering needle realizes sucking and the discharge liquid of the first liquid-transfering needle and the second liquid-transfering needle.
Description
Technical field
The present invention relates to biological medicine equipment technical field more particularly to a kind of liquid transcription devices.
Background technique
With the rapid development of science and technology, the research work of biology, chemical laboratory is no longer around several equipment, behaviour
If making the small scale experiments of dry-eye disease, but it is a variety of in face of increasingly complex research object and growing number of sample size, use
Experimental technique carries out multipath, diversified large scale experiment.Such as the library screening, gene order-checking and genetic chip of genetics
Research, searching, identification, the screening of protein crystal, the analysis of higher structure of differential protein in terms of proteomics, there are also new
The quantity of sample handling work that the laboratories such as the extensive screening compound of medicine discovery aspect and identification are born daily increasingly increases.
And in many laboratories and R&D institution, extraction and the sample-adding of many samples are manually to operate entirely, and hand-held pipettor is general
There are four elemental motions --- and suction nozzle is set up, liquid is taken, liquid feeding, throws away suction nozzle, these are entirely by manually completing.Manual operation is deposited
In problems: a large amount of sample treatment work not only needs a large amount of manpower and material resources and time, but also due to manual operation
Many human errors are brought, so that the liquid relief accuracy of sample treatment is low, error probability is high, the stability of sample treatment and can weigh
Renaturation is poor.Manual mode of operation is no longer satisfied high efficiency, accuracy and peace required in high-throughput sample handling processes
Quan Xing.Part in experimental implementation process or overall process are realized that automatic operating has become inevitable trend.
In multiple holes that current existing liquid relief processing system be used to for reagent, sample etc. being transported on porous plate,
But only one distributor gear of liquid relief processing system and a mobile mechanism, it encounters and is unable to unrestricted choice when doing certain experiments
Single channel liquid feeding or multichannel carry out liquid feeding, and piston rod is arranged on the liquid-transfering needle on distributor gear, for sucking and
Liquid is discharged, its structure is complicated, in order to guarantee that piston rod has enough strokes, so that the height of the liquid relief processing system is spent
Height, and the inside of distributor gear is easy to produce pollution and corrosion, and daily operation and maintenance are cumbersome.
Summary of the invention
In order to overcome the shortcomings of the prior art, the present invention provides a kind of liquid transcription device, can unrestricted choice progress
Multichannel liquid feeding or single channel liquid feeding, and the fluid means for drawing liquid and liquid-transfering device are provided separately, guarantee tool
There is sufficiently long stroke, avoids generating pollution.
In order to solve the above-mentioned technical problems, the present invention provides a kind of liquid transcription devices, including frame, loading area, shifting
Liquid device and fluid means, the loading area, the liquid-transfering device and the fluid means are set on the frame, described
Loading area is equipped with the carrier for accommodating kit, and the fluid means is connected with the liquid-transfering device, and the frame is equipped with
For controlling the first guide rail mechanism of the liquid-transfering device transverse shifting,
The liquid-transfering device includes the second guide rail mechanism, liquid relief mounting rack, multichannel pipetting device and single channel liquid relief
Mechanism, second guide rail mechanism are set on first guide rail mechanism, the direction of motion and second of first guide rail mechanism
The direction of motion of guide rail mechanism is vertical, and the liquid relief mounting rack is set on second guide rail mechanism, the multichannel liquid relief machine
Structure includes the first liquid-transfering needle of the first lifting assembly and several arranged in parallel, and first lifting assembly is set to the liquid relief
On mounting rack, each first liquid-transfering needle is connected with first lifting assembly, and each first liquid-transfering needle is described first
It is moved up and down along the vertical direction under the control of lifting assembly, the single channel pipetting device includes the second lifting assembly and second
Liquid-transfering needle, second lifting assembly are set on the liquid relief mounting rack, second liquid-transfering needle and second lifting assembly
It is connected, second liquid-transfering needle moves up and down along the vertical direction under the control of second lifting assembly,
The fluid means includes fluid fixed plate, multichannel pipe drawing mechanism and single channel pipe drawing mechanism, the fluid
Fixed plate is set on the frame, and the multichannel pipe drawing mechanism includes the first pushing component and quantity and first liquid relief
Several identical first trombone slides of needle, first pushing component and first trombone slide are set in the fluid fixed plate, respectively
First trombone slide is connected with corresponding first liquid-transfering needle, and first pushing component is connected with first trombone slide
It connects, gas, the single channel bench are released under the control of first pushing component or sucked to each first trombone slide
Structure includes the second pushing component and the second trombone slide, and second pushing component and second trombone slide are set to the fluid and fix
On plate, second trombone slide is connected with second liquid-transfering needle, and second pushing component is connected with second trombone slide,
Gas is released under the control of second pushing component or sucked to second trombone slide.
Preferably, first lifting assembly includes the first actuator, the first sliding rail, the first sliding block and is used for
First fixing piece of fixed each first liquid-transfering needle, first sliding rail and first actuator are installed set on the liquid relief
On frame, the two sides of first fixing piece are connected with first sliding block respectively, first sliding block and second sliding rail
Slidable connection, first fixing piece are connected with the output end of first actuator.
Preferably, second lifting assembly includes the second actuator, the second sliding rail, the second sliding block and is used for
The clamping piece of second liquid-transfering needle is clamped, second sliding rail and second actuator are set on the liquid relief mounting rack,
The clamping piece is set on second sliding block, second sliding block and the second sliding rail slidable connection, and described second is sliding
Block is connected with the output end of second actuator.
Preferably, the multichannel pipetting device further includes that first be set on first fixing piece moves back mouth group
Part, described first move back nozzle assembly include third actuator and it is L-shaped move back mouth plate, the third actuator is set to described first
On fixing piece, the mouth plate that moves back is connected with the output end of the third actuator, and the mouth plate that moves back is equipped with for across each
The hole location of first liquid-transfering needle.
Preferably, the single channel pipetting device further includes second moving back nozzle assembly, and described second moves back nozzle assembly packet
The round tube being located on the outside of second liquid-transfering needle is included, the round tube is set on the liquid relief mounting rack.
Preferably, first pushing component includes fourth drive member and pushing plate, and first trombone slide is set
In the front of the fluid fixed plate, the fourth drive member be set to the fluid fixed plate the back side, the one of the pushing plate
End is connected with the push rod of first trombone slide, and the other end of the pushing plate is connected with the output end of the fourth drive member
It connects.
Preferably, second pushing component includes the 5th actuator, and second trombone slide is set to the fluid
The front of fixed plate, the 5th actuator be set to the fluid fixed plate the back side, the push rod of second trombone slide with it is described
The output end of fourth drive member is connected.
Preferably, the frame is equipped with partition along vertical direction, and the fluid fixed plate is set to the partition
On.
Preferably, the fluid means further includes wiper mechanism.
Preferably, the wiper mechanism includes cleaning pump and the solenoid valve that is connected with the cleaning pump, institute
It states cleaning pump and the solenoid valve is set in the fluid fixed plate, the solenoid valve and first liquid-transfering needle and described second
Liquid-transfering needle is connected.
Liquid transcription device provided by the present invention, compared with prior art, the beneficial effect is that: the first guide rail machine
Structure realizes movement of the liquid-transfering device in X-axis, and second guide rail mechanism realizes shifting of the liquid-transfering device in Y-axis
Dynamic, the multichannel pipetting device and the single channel pipetting device are real by corresponding first lifting assembly and the second lifting assembly
The now movement of independent Z axis realizes first liquid-transfering needle and the second liquid-transfering needle being separately controlled in XYZ axis, according to demand
Unrestricted choice carries out multichannel liquid feeding or single channel liquid feeding, is connected to institute using the first trombone slide on the multichannel pipe drawing mechanism
The first liquid-transfering needle is stated, the second trombone slide on the single channel pipe drawing mechanism is connected to second liquid-transfering needle, realizes that described first moves
The sucking of liquid needle and second liquid-transfering needle and discharge liquid, the liquid-transfering device and the fluid means are provided separately, are protecting
When card is longer with stroke, so that the fluid means not will receive the pollution of liquid, and the height of integral device can be reduced,
Widely applicable, integrally-built layout is more reasonable.
Detailed description of the invention
In order to illustrate more clearly of technical solution of the present invention, attached drawing needed in embodiment will be made below
Simply introduce, it should be apparent that, the accompanying drawings in the following description is only some embodiments of the present invention, general for this field
For logical technical staff, without creative efforts, it is also possible to obtain other drawings based on these drawings.
Fig. 1 is the schematic perspective view of the liquid transcription device of the preferred embodiment of the invention.
Fig. 2 is the schematic diagram of internal structure of the liquid transcription device of the preferred embodiment of the invention.
Fig. 3 is the structural schematic diagram of the liquid-transfering device of the liquid transcription device of the preferred embodiment of the invention.
Fig. 4 is the schematic diagram of internal structure of the liquid-transfering device of the liquid transcription device of the preferred embodiment of the invention.
Fig. 5 is the structural schematic diagram of the fluid means of the liquid transcription device of the preferred embodiment of the invention.
Fig. 6 is another viewing angle constructions schematic diagram of Fig. 5.
Fig. 7 is the structural schematic diagram of the extraction element of the liquid transcription device of the preferred embodiment of the invention.
Fig. 8 is the structural schematic diagram of fixed mechanism in the extraction element of the liquid transcription device of the preferred embodiment of the invention.
Fig. 9 is the side view structure signal of fixed mechanism in the extraction element of the liquid transcription device of the preferred embodiment of the invention
Figure.
Figure 10 is the structural schematic diagram in the extraction element of the liquid transcription device of the preferred embodiment of the invention from press mechanism.
Figure 11 is the structural schematic diagram of the clamp device of the liquid transcription device of the preferred embodiment of the invention.
In figure:
100. frame；110. the first guide rail mechanism；120. partition；
200. loading area；210. carrier；220. kit；230. waste liquid frames；240. fluid cartridge；250. emptying boxes；260.
Suction nozzle box；270. Riker mount；
300. liquid-transfering device；310. second guide rail mechanisms；320. liquid relief mounting racks；330. multichannel pipetting devices；331.
First liquid-transfering needle；332. first actuators；333. first sliding rails；334. first sliding blocks；335. first fixing pieces；336. thirds are driven
Moving part；337. move back mouth plate；340. single channel pipetting devices；341. second liquid-transfering needles；342. second actuators；343. second is sliding
Rail；344. second sliding blocks；345. clamping piece；346. round tube；
400. fluid means；410. fluid fixed plates；420. multichannel pipe drawing mechanisms；421. first trombone slides；422. the 4th
Actuator；423. pushing plate；430. single channel pipe drawing mechanisms；431. second trombone slides；432. the 5th actuators；433. link block；
440. wiper mechanism；441. cleaning pump；442. solenoid valve；
500. extraction element；510. fixed mechanism；511. positioning plate；512. control circuit board；513. elastic probe；514.
Magnetic bead；520. from press mechanism；521. press actuator certainly；522. press mounting rack certainly；523. press sliding rail certainly；524. press sliding block certainly；
525. pressing plate；526. convex wall；
600. clamp device；610. third guide rail mechanisms；620. lifting mounting racks；630. clamping mounting racks；640. the 6th
Actuator；650. third sliding rails；660. third sliding blocks；670. gripper cylinder；680. first gripper jaws；690. second gripper jaws.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
In the present invention, it is answered unless otherwise specific regulation and restriction, the terms such as term " connected ", " connection ", " fixation "
It is interpreted broadly, for example, it may be being fixedly connected, may be a detachable connection, or is integral；It can be mechanical connection,
It can be electrical connection；It can be directly connected, the company inside two elements can also be can be indirectly connected through an intermediary
Logical or two elements interaction relationship, unless otherwise restricted clearly.For the ordinary skill in the art, may be used
To understand the concrete meaning of above-mentioned term in the present invention as the case may be.
In the description of the present invention, the orientation or positional relationship of the instructions such as term " on ", "lower" is based on the figure
Orientation or positional relationship is merely for convenience of description of the present invention and simplification of the description, rather than the device of indication or suggestion meaning or
Element must have a particular orientation, be constructed and operated in a specific orientation, therefore be not considered as limiting the invention.This
Outside, it should be noted that term " first ", " second " etc. are used for description purposes only, and are not understood to indicate or imply opposite
Importance.
As shown in Figure 1 to 11, the preferred embodiment of the invention provides a kind of liquid transcription device, including frame 100,
Loading area 200, liquid-transfering device 300 and fluid means 400, the loading area 200, the liquid-transfering device 300 and the stream
Body device 400 is set on the frame 100, and the loading area 200 is equipped with the carrier 210 for accommodating kit 220, the stream
Body device 400 is connected with the liquid-transfering device 300, and the frame 100 is equipped with laterally to be moved for controlling the liquid-transfering device 300
The first dynamic guide rail mechanism 110,
The liquid-transfering device 300 include the second guide rail mechanism 310, liquid relief mounting rack 320, multichannel pipetting device 330 with
And single channel pipetting device 340, second guide rail mechanism 310 are set on first guide rail mechanism 110, first guide rail
The direction of motion of mechanism 110 is vertical with the direction of motion of the second guide rail mechanism 310, and the liquid relief mounting rack 320 is set to described the
On two guide rail mechanisms 310, the multichannel pipetting device 330 includes the first of the first lifting assembly and several arranged in parallel
Liquid-transfering needle 331, first lifting assembly are set on the liquid relief mounting rack 320, each first liquid-transfering needle 331 and described the
One lifting assembly is connected, and each first liquid-transfering needle 331 is upper and lower along the vertical direction under the control of first lifting assembly
Mobile, the single channel pipetting device 340 includes the second lifting assembly and the second liquid-transfering needle 341, second lifting assembly
On the liquid relief mounting rack 320, second liquid-transfering needle 341 is connected with second lifting assembly, and described second moves
Liquid needle 341 moves up and down along the vertical direction under the control of second lifting assembly,
The fluid means 400 includes fluid fixed plate 410, multichannel pipe drawing mechanism 420 and single channel pipe drawing mechanism
430, the fluid fixed plate 410 is set on the frame 100, and the multichannel pipe drawing mechanism 420 includes the first pushing component
And quantity several first trombone slides 421 identical with first liquid-transfering needle 331, first pushing component and described first
Trombone slide 421 is set in the fluid fixed plate 410, and each first trombone slide 421 is connected with corresponding first liquid-transfering needle 331
Logical, first pushing component is connected with first trombone slide 421, and each first trombone slide 421 is in the first promotion group
Gas is released or sucked under the control of part, and the single channel pipe drawing mechanism 430 includes the second pushing component and the second trombone slide
431, second pushing component and second trombone slide 431 are set in the fluid fixed plate 410, second trombone slide 431
It is connected with second liquid-transfering needle 341, second pushing component is connected with second trombone slide 431, and described second draws
Gas is released under the control of second pushing component or sucked to pipe 431.
Based on the liquid transcription device of above-mentioned technical characteristic, first guide rail mechanism 110 realizes the liquid-transfering device
300 movement in X-axis, second guide rail mechanism 310 realize movement of the liquid-transfering device 300 in Y-axis, the multi-pass
Road pipetting device 330 and the single channel pipetting device 340 are realized only by corresponding first lifting assembly and the second lifting assembly
The movement of vertical Z axis, realizes first liquid-transfering needle 331 and being separately controlled in XYZ axis of the second liquid-transfering needle 341, according to need
It asks unrestricted choice to carry out multichannel liquid feeding or single channel liquid feeding, utilizes the first trombone slide on the multichannel pipe drawing mechanism 420
421 are connected to first liquid-transfering needles 331, and the second trombone slide 431 on the single channel pipe drawing mechanism 430 is connected to second liquid relief
Needle 341 realizes sucking and the discharge liquid of first liquid-transfering needle 331 and second liquid-transfering needle 341, the liquid-transfering device
300 and the fluid means 400 be provided separately, guarantee have stroke it is longer when so that the fluid means 400 not will receive
The pollution of liquid, and the height of integral device can be reduced, widely applicable, integrally-built layout is more reasonable.
In the present embodiment, as shown in Fig. 2, the carrier 210 on the loading area 200, which can be also used for placing, holds reagent
Fluid cartridge 240, emptying box 250, suction nozzle box 260 and the Riker mount 270 of liquid, can putting according to experimenter
It puts, wherein the side of the loading area 200 is additionally provided with waste liquid frame 230, for holding waste water and used suction after cleaning
Mouth.In addition, the quantity of first liquid-transfering needle 331 is 8, it is able to achieve the work of eight channel liquid feedings.
In the present embodiment, as shown in Figures 2 and 3, first lifting assembly is sliding including the first actuator 332, first
Rail 333, the first sliding block 334 and the first fixing piece 335 for fixing each first liquid-transfering needle 331, first sliding rail
333 and first actuator 332 be set to the liquid relief mounting rack 320 on, the two sides of first fixing piece 335 respectively with institute
The first sliding block 334 is stated to be connected, first sliding block 334 and 343 slidable connection of the second sliding rail, described first is fixed
Part 335 is connected with the output end of first actuator 332, and first actuator 332 passes through feed screw nut's structure control
First fixing piece 335 is moved up and down along first sliding rail 333, to drive the upper and lower of first liquid-transfering needle 331
Mobile, stable structure is reliable, realizes movement of first liquid-transfering needle 331 on Z axis.
In the present embodiment, second lifting assembly includes the second actuator 342, the second sliding rail 343, the second sliding block
344 and the clamping piece 345 for clamping second liquid-transfering needle 341, second sliding rail 343 and second actuator
342 are set on the liquid relief mounting rack 320, and the clamping piece 345 is set on second sliding block 344, second sliding block 344
With 343 slidable connection of the second sliding rail, second sliding block 344 is connected with the output end of second actuator 342,
Second actuator 342 is moved down on second sliding rail 343 by the second sliding block 344 described in feed screw nut's structure control
It is dynamic, so that the clamping piece 345 drives second liquid-transfering needle 341 to move up and down, occupy little space, stable structure is reliable, real
Existing movement of second liquid-transfering needle 341 on Z axis.
Further, the multichannel pipetting device 330 further includes that first be set on first fixing piece 335 moves back mouth
Component, described first, which moves back nozzle assembly, includes third actuator 336 and L-shaped moves back mouth plate 337, the third actuator 336
On first fixing piece 335, the mouth plate 337 that moves back is connected with the output end of the third actuator 336, described to move back
Mouth plate 337 is equipped with for the hole location across each first liquid-transfering needle 331, and the third actuator 336 passes through feed screw nut
Moving up and down for mouth plate 337 is moved back described in structure control, when first liquid-transfering needle 331 needs to replace new suction nozzle, starts institute
State third actuator 336 make it is described move back mouth plate 337 and move down, can disposably will be on all first liquid-transfering needles 331
Suction nozzle declines, and the mouth movement of moving back of first liquid-transfering needle 331 carries out independent control, is conducive to shorten first liquid-transfering needle
331 length reduces control cost.
Further, the single channel pipetting device 340 further includes second moving back nozzle assembly, and described second, which moves back nozzle assembly, includes
Round tube 346 positioned at 341 outside of the second liquid-transfering needle, the round tube 346 are set on the liquid relief mounting rack 320, the list
Channel pipetting device 340 occupies little space, and controls second liquid-transfering needle 341 by second actuator 342 and moves up and down,
When the suction nozzle of second liquid-transfering needle 341 and the round tube 346 abut against, which is declined, so that the single-pass
Road pipetting device 340 is more compact.
In the present embodiment, as shown in Figures 5 and 6, first pushing component includes fourth drive member 422 and pushes
Plate 423, first trombone slide 421 are set to the front of the fluid fixed plate 410, and the fourth drive member 422 is set to the stream
The back side of body fixed plate 410, one end of the pushing plate 423 are connected with the push rod of first trombone slide 421, the pushing plate
423 other end is connected with the output end of the fourth drive member 422, and the fourth drive member 422 is tied by feed screw nut
Structure controls moving up and down for the pushing plate 423, achievees the purpose that air-breathing and exhaust while all first trombone slide 421,
It realizes the sucking of all first liquid-transfering needles 331 and the function of liquid is discharged, wherein first liquid-transfering needle 331 and described
First trombone slide 421 can be connected to by soft suction pipe (attached drawing does not identify), and the pushing plate 423 is set by sliding block guide track structure
In in the fluid fixed plate 410 so that the pushing plate 423 push it is more reliable and more stable.
In the present embodiment, second pushing component includes the 5th actuator 432, and second trombone slide 431 is set to institute
The front of fluid fixed plate 410 is stated, the 5th actuator 432 is set to the back side of the fluid fixed plate 410, and described second draws
The push rod of pipe 431 is connected by link block 433 with the output end of the 5th actuator 432, and the 5th actuator 432 is logical
The push rod for crossing the second trombone slide 431 described in feed screw nut's structure control moves up and down, and so that it is carried out air-breathing and exhaust, realizes all institutes
It states the sucking of the second liquid-transfering needle 341 and the function of liquid is discharged, second liquid-transfering needle 341 and second trombone slide 431 can be with
It is connected to by soft suction pipe (attached drawing does not identify).
In the present embodiment, the fluid means 400 further includes wiper mechanism 440, for cleaning first liquid-transfering needle
331 and second liquid-transfering needle 341, avoid different liquids from mixing.
Further, the wiper mechanism 440 includes cleaning pump 441 and the electromagnetism being connected with the cleaning pump 441
Valve 442, the cleaning pump 441 and the solenoid valve 442 be set to the fluid fixed plate 410 on, the solenoid valve 442 with it is described
First liquid-transfering needle 331 is connected with second liquid-transfering needle 341, wherein the cleaning pump 441 is peristaltic pump, when needing to clean
When first liquid-transfering needle 331 and second liquid-transfering needle 341, cleaning solution is smoked in the peristaltic pump unlatching is transmitted to the electricity
It on magnet valve 442, then is diverted on tee tube by the principle of 442 one-in-and-two-out of solenoid valve, wherein one on tee tube goes out
Mouth, which is automatically closed from another outlet manifold, goes out first item cleaning solution, after carrying out first pass cleaning, 442 meeting of solenoid valve
The outlet is automatically closed, in addition a cleaning solution exports automatic cleaning second time by another, guarantees to clean up.
Wherein, during the experiment, when the work of eight channel liquid feedings of selection, single channel is automatically stopped, at this moment by the liquid relief
Device 300 is moved to above 260 position of suction nozzle box that experimenter sets, and it is automatic to control all first liquid-transfering needles 331
Drop on suction nozzle box 260 and be inserted into suction nozzle, first liquid-transfering needle 331 rises after being inserted into suction nozzle, then by the liquid-transfering device
300 are moved to 240 top of fluid cartridge, while first liquid-transfering needle 331 lands automatically, the multichannel pipe drawing mechanism 420
Starting, first trombone slide 421 is on liquid assimilating to first liquid-transfering needle 331, and at this moment the liquid-transfering device 300 rises automatically
It plays certain position and is moved to 220 top of kit, when dropping to certain position automatically again, the multichannel bench
Structure 420 starts pushing out gas, so that liquid is discharged first liquid-transfering needle 331, realizes the pipetting function to kit 220.
When be again started up different liquids are shifted when, need for the liquid-transfering device 300 to be moved on the waste liquid frame 230, utilize electricity
Mouth plate 337 is moved back described in machine control disposably suction nozzle declines, and first liquid-transfering needle 331 is cleaned.Select single channel
When liquid feeding works as the principle in eight channels, details are not described herein.
In addition, the liquid transcription device further includes clamp device 600 for clamping kit 220 and for extracting
The extraction element 500 of cell, the clamp device 600 and the extraction element 500 are set on the frame 100,
As shown in Figure 7 to 10, the extraction element 500 is described solid including fixed mechanism 510 and from press mechanism 520
Determine mechanism 510 and includes positioning plate 511, control circuit board 512, several elastic probes 513 and several magnetic beads 514, it is described
Positioning plate 511 is set on the loading area 200, and the magnetic bead 514 is set on the positioning plate 511, the control circuit board 512
Positioned at the lower section of the positioning plate 511, the elastic probe 513 is located at the periphery of the magnetic bead 514, each elastic probe
513 are connected with the control circuit board 512, it is described from press mechanism 520 include from pressure actuator 521, from pressure mounting rack 522,
From pressure sliding rail 523, from pressure sliding block 524 and pressing plate 525, it is described to be set on the frame 100 from pressure mounting rack 522, it is described certainly
Press actuator 521 and it is described be set to from pressure sliding rail 523 it is described from pressure mounting rack 522, it is described from press sliding block 524 set on the pressure
On plate 525, it is described from pressure sliding block 524 and it is described from pressure 523 slidable connection of sliding rail, one end of the pressing plate 525 and it is described from
The output end of pressure actuator 521 is connected, and the other end of the pressing plate 525 is the free end abutted against with the positioning plate 511.
It is realized using the cooperation of the fluid means 400 and the liquid-transfering device 300 and liquid is transferred to the kit
On 220, the clamp device 600 will be completed in the clamping to the positioning plate 511 of kit 220 that liquid adds, by described
Pressing plate 525 pushes the kit 220, and the elastic probe 513 has elastic force, guarantees each of the kit 220
A cell can be in contact with the elastic probe 513, during the kit 220 pushes, the elastic probe 513
Impurity absorption is sunk when generating faint electric current to be transmitted on kit 220, while encountering the magnetic bead 514, by institute
Multiple cells are broken up after stating the faint electric current of elastic probe 513, the extraction to a part of living cells are realized, on workbench
It realizes extraction to living cells, avoids artificial transfer process by the pollution of the microorganisms such as bacterial virus in air, as a result surely
Fixed reliable, treatment effeciency is high, substantially increases the utilization rate of equipment, reduces sample treatment cost.
Wherein, described to be moved up and down from pressure actuator 521 by pressing plate 525 described in feed screw nut's structure control, realization pair
The pushing of the kit 220, the actuator 521 of pressure certainly is motor.
In the present embodiment, the fixed plate is equipped with the groove to lower recess, and the free end is U-shaped, the freedom
The two sides at end are equipped with the convex wall 526 abutted against with the two sides of the groove, the shape of the shape of the groove and the kit 220
Shape matches, and the kit 220 is placed in the groove, during the pressing plate 525 pushes, the convex wall
526 abut against with the kit 220, guarantee to press down the kit 220, wherein are equipped with and are used in the groove
Detect the sensor of the kit 220.
In the present embodiment, the periphery of each magnetic bead 514 is set there are four the elastic probe 513, described in four
The distribution of 513 rectangular array of elastic probe, each cell phase of each described elastic probe 513 and the kit 220
It is corresponding, guarantee that each cell is connected with electric current, each described magnetic bead 514 carries out the absorption of impurity to four cells.
Further, described to be set to the two sides for pressing mounting rack 522 certainly from pressure sliding rail 523, it is described to be set from pressure sliding block 524
It ensure that in the two sides of the pressing plate 525 by what is matched described in two sides from pressure sliding block 524 and the sliding rail 523 of pressure certainly
The balance that the pressing plate 525 pushes is in contact so that the kit 220 steadily moves down with the elastic probe 513.
In the present embodiment, the frame 100 is equipped with partition 120 along vertical direction, described to be set to from pressure mounting rack 522
The back side of the partition 120, the positioning plate 511 are located at the front of the partition 120, and the partition 120, which is equipped with, supplies the pressure
Plate 525 achievees the purpose that installation is described from press mechanism 520 through the waist-shaped hole between the front and back of the partition 120,
Wherein, the fluid fixed plate 410 is set on the partition 120, realizes that the fluid means 400 is placed in the vertical direction.
In the present embodiment, the first guide rail mechanism 110 on the frame 100 can be also used for controlling the clamp device
600 transverse shiftings realize the movement for controlling the X-axis of the clamp device 600.
Further, as shown in figure 11, the clamp device 600 include third guide rail mechanism 610, lifting mounting rack 620,
Mounting rack 630, third lifting assembly and gripper assembly are clamped, the third guide rail mechanism 610 is set to the first guide rail machine
On structure 110, the direction of motion of first guide rail mechanism 110 is vertical with the direction of motion of third guide rail mechanism 610, the lifting
Mounting rack 620 is set on first guide rail mechanism 110, and the third lifting assembly is set on the lifting mounting rack 620, institute
Gripper assembly is stated on the clamping mounting rack 630, the clamping mounting rack 630 is connected with the third lifting assembly,
The third guide rail mechanism 610 realizes movement of the clamp device 600 in Y-axis, and the third lifting assembly realizes
Lifting of the gripper assembly on Z axis, wherein the third lifting assembly includes the 6th actuator 640, third sliding rail 650
And third sliding block 660, the 6th actuator 640 and the third sliding rail 650 are set on the lifting mounting rack 620, institute
Third sliding block 660 is stated on the clamping mounting rack 630, the third sliding block 660 slidably connects with the third sliding rail 650
It connects, the clamping mounting rack 630 is connected with the output end of the 6th actuator 640, and the clamping mounting rack 630 is described
It under the driving of 6th actuator 640, is moved up and down along the third sliding rail 650, realizes its lifting on Z axis.
Further, the gripper assembly includes gripper cylinder 670, the first gripper jaw 680 and the second gripper jaw 690,
First gripper jaw 680 and second gripper jaw 690 are connected with two output ends of the gripper cylinder 670 respectively,
First gripper jaw 680 and second gripper jaw 690 are oppositely arranged, and control described first by the gripper cylinder 670
Gripper jaw 680 and the second gripper jaw 690 move toward one another, and achieve the purpose that the clamping kit 220, realize kit
220, which are moved to the positioning plate 511, carries out the extraction of cell, and can be overlapped to kit 220, reaches demand
Amount.
In the present embodiment, it is to be understood that first guiding mechanism, second guiding mechanism and described
Three guiding mechanisms are the synchronous belt guiding mechanism for being able to achieve transverse shifting function, and specific structure is the prior art, herein
It repeats no more.
First actuator 332, the second actuator 342, third actuator 336, fourth drive member the 422, the 5th drive
Part 432 and the 6th actuator 640 are motor.
In conclusion liquid transcription device provided by the embodiment of the present invention mainly has the advantage that (1) described liquid relief
Device 300 and the clamp device 600 can move in XYZ axis direction, realize kinds of experiments function, and treatment effeciency is high；(2) energy
Unrestricted choice carries out multichannel liquid feeding or single channel liquid feeding, provides multiple choices for experimenter；(3) liquid-transfering device
300 and the fluid means 400 be provided separately, guarantee have stroke it is longer when so that the fluid means 400 not will receive
The pollution of liquid；(4) clamping device, which is able to achieve, is moved to the extraction that the positioning plate 511 carries out cell for kit 220,
And kit 220 can be overlapped, reach the amount of demand；(5) extraction element 500 will be lived carefully using electric current is generated
Born of the same parents extract, and are precipitated impurity absorption down using the magnetic bead 514；(6) utilize described in move back mouth plate 337 disposably push away fall it is more
Suction nozzle on channel pipetting device 330 can shorten the length of first liquid-transfering needle 331, reduce manufacturing cost.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although
Present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that: it still may be used
To modify the technical solutions described in the foregoing embodiments or equivalent replacement of some of the technical features；
And these are modified or replaceed, technical solution of various embodiments of the present invention that it does not separate the essence of the corresponding technical solution spirit and
Range.
Claims (10)
1. a kind of liquid transcription device, which is characterized in that including frame, loading area, liquid-transfering device and fluid means, the dress
It carries area, the liquid-transfering device and the fluid means to be set on the frame, the loading area is equipped with for accommodating kit
Carrier, the fluid means is connected with the liquid-transfering device, and the frame is equipped with lateral for controlling the liquid-transfering device
The first mobile guide rail mechanism,
The liquid-transfering device includes the second guide rail mechanism, liquid relief mounting rack, multichannel pipetting device and single channel pipetting device,
Second guide rail mechanism is set on first guide rail mechanism, the direction of motion of first guide rail mechanism and the second guide rail machine
The direction of motion of structure is vertical, and the liquid relief mounting rack is set on second guide rail mechanism, and the multichannel pipetting device includes
First liquid-transfering needle of the first lifting assembly and several arranged in parallel, first lifting assembly are set to the liquid relief mounting rack
On, each first liquid-transfering needle is connected with first lifting assembly, and each first liquid-transfering needle is in the first lifting group
It is moved up and down along the vertical direction under the control of part, the single channel pipetting device includes the second lifting assembly and the second liquid relief
Needle, second lifting assembly are set on the liquid relief mounting rack, and second liquid-transfering needle is connected with second lifting assembly
It connecing, second liquid-transfering needle moves up and down along the vertical direction under the control of second lifting assembly,
The fluid means includes fluid fixed plate, multichannel pipe drawing mechanism and single channel pipe drawing mechanism, and the fluid is fixed
Plate is set on the frame, and the multichannel pipe drawing mechanism includes the first pushing component and quantity and the first liquid-transfering needle phase
Several same first trombone slides, first pushing component and first trombone slide are set in the fluid fixed plate, each described
First trombone slide is connected with corresponding first liquid-transfering needle, and first pushing component is connected with first trombone slide, respectively
First trombone slide is released under the control of first pushing component or sucks gas, and the single channel pipe drawing mechanism includes
Second pushing component and the second trombone slide, second pushing component and second trombone slide are set in the fluid fixed plate,
Second trombone slide is connected with second liquid-transfering needle, and second pushing component is connected with second trombone slide, described
Gas is released under the control of second pushing component or sucked to second trombone slide.
2. liquid transcription device according to claim 1, which is characterized in that first lifting assembly includes the first driving
Part, the first sliding rail, the first sliding block and the first fixing piece for fixing each first liquid-transfering needle, first sliding rail and institute
The first actuator is stated on the liquid relief mounting rack, the two sides of first fixing piece are connected with first sliding block respectively
It connects, first sliding block and the second sliding rail slidable connection, the output of first fixing piece and first actuator
End is connected.
3. liquid transcription device according to claim 1, which is characterized in that second lifting assembly includes the second driving
Part, the second sliding rail, the second sliding block and the clamping piece for clamping second liquid-transfering needle, second sliding rail and described second
Actuator is set on the liquid relief mounting rack, and the clamping piece is set on second sliding block, second sliding block and described the
Two sliding rail slidable connections, second sliding block are connected with the output end of second actuator.
4. liquid transcription device according to claim 2, which is characterized in that the multichannel pipetting device further includes being set to
First on first fixing piece moves back nozzle assembly, and described first, which moves back nozzle assembly, includes third actuator and L-shaped move back mouth
Plate, the third actuator are set on first fixing piece, and the mouth plate that moves back is connected with the output end of the third actuator
It connects, the mouth plate that moves back is equipped with for the hole location across each first liquid-transfering needle.
5. liquid transcription device according to claim 3, which is characterized in that the single channel pipetting device further includes second
Move back nozzle assembly, described second to move back nozzle assembly include the round tube on the outside of second liquid-transfering needle, and the round tube is set to the shifting
On liquid mounting rack.
6. liquid transcription device according to claim 1, which is characterized in that first pushing component includes the 4th driving
Part and pushing plate, first trombone slide are set to the front of the fluid fixed plate, and the fourth drive member is set to the fluid
The back side of fixed plate, one end of the pushing plate are connected with the push rod of first trombone slide, the other end of the pushing plate with
The output end of the fourth drive member is connected.
7. liquid transcription device according to claim 1, which is characterized in that second pushing component includes the 5th driving
Part, second trombone slide are set to the front of the fluid fixed plate, and the 5th actuator is set to the back of the fluid fixed plate
The push rod in face, second trombone slide is connected with the output end of the fourth drive member.
8. liquid transcription device according to claim 1, which is characterized in that the frame be equipped with along vertical direction every
Plate, the fluid fixed plate are set on the partition.
9. liquid transcription device according to claim 1 to 8, which is characterized in that the fluid means further includes
Wiper mechanism.
10. liquid transcription device according to claim 9, which is characterized in that the wiper mechanism include cleaning pump and
The solenoid valve being connected with the cleaning pump, the cleaning pump and the solenoid valve are set in the fluid fixed plate, the electricity
Magnet valve is connected with first liquid-transfering needle and second liquid-transfering needle.
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| CN201910058734.8A CN109675649B (en) | 2019-01-22 | 2019-01-22 | Liquid transfer equipment |
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|---|---|---|---|
| CN201910058734.8A CN109675649B (en) | 2019-01-22 | 2019-01-22 | Liquid transfer equipment |
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| CN109675649B CN109675649B (en) | 2024-08-30 |
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| CN110007103A (en) * | 2019-04-28 | 2019-07-12 | 北京奥美泰克科技发展有限公司 | A kind of compact independence multichannel liquor removing workstation |
| CN111167532A (en) * | 2020-01-10 | 2020-05-19 | 济南翼菲自动化科技有限公司 | Automatic device for biological test liquid transfer |
| CN112550791A (en) * | 2020-12-23 | 2021-03-26 | 郑州寰基基因科技有限公司 | Liquid split charging device |
| CN112657566A (en) * | 2020-11-19 | 2021-04-16 | 北京化工大学 | Automatic liquid transfer device |
| CN112808340A (en) * | 2020-12-31 | 2021-05-18 | 广西机电职业技术学院 | Multistation high flux liquid moving equipment |
| CN113736627A (en) * | 2021-09-30 | 2021-12-03 | 北京卓诚惠生生物科技股份有限公司 | PCR system liquid injection device capable of automatically replacing syringe needle |
| CN115122308A (en) * | 2022-08-31 | 2022-09-30 | 北京凯祥弘康生物科技有限公司 | Full-automatic transplanting liquid-transferring mechanical arm and working method thereof |
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| CN113736627A (en) * | 2021-09-30 | 2021-12-03 | 北京卓诚惠生生物科技股份有限公司 | PCR system liquid injection device capable of automatically replacing syringe needle |
| CN113736627B (en) * | 2021-09-30 | 2022-04-08 | 北京卓诚惠生生物科技股份有限公司 | PCR system liquid injection device capable of automatically replacing syringe needle |
| CN115122308A (en) * | 2022-08-31 | 2022-09-30 | 北京凯祥弘康生物科技有限公司 | Full-automatic transplanting liquid-transferring mechanical arm and working method thereof |
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