CN113985049A

CN113985049A - Full-automatic chemiluminescence immunoassay analyzer

Info

Publication number: CN113985049A
Application number: CN202110113751.4A
Authority: CN
Inventors: 许行尚; 杰弗瑞·陈
Original assignee: Nanjing Lanyu Biological Technology Co Ltd
Current assignee: Nanjing Lanyu Biological Technology Co Ltd
Priority date: 2021-01-27
Filing date: 2021-01-27
Publication date: 2022-01-28

Abstract

The invention discloses a full-automatic chemiluminescence immunoassay analyzer, which comprises a reaction cup loading module, a sample loading module, a kit loading module, a detection module and a magnetic separation cleaning module which are integrated on a base and are mutually independent; the kit loading module is used for storing reaction reagents; the reaction cup loading module is used for carrying the reaction cup to a preset position; the magnetic separation cleaning module is used for cleaning a reaction cup added with a sample and a reaction reagent, and the cleaned reaction cup is transferred to the detection module for detection; the reaction cup loading module, the sample loading module and the kit loading module are all positioned at the front end region of the analyzer; the detection module and the magnetic separation cleaning module are both positioned at the rear end region of the analyzer. The detection module and the magnetic separation cleaning module are both located in the rear end region of the analyzer, different operation times are staggered, efficiency is improved, the pollution-free degree of the rear end region is relatively higher, the structural layout is more reasonable, and the user experience effect is good.

Description

Full-automatic chemiluminescence immunoassay analyzer

Technical Field

The invention belongs to the technical field of medical equipment, and particularly relates to a full-automatic chemiluminescence immunoassay analyzer for a chemiluminescence diagnosis technology.

Background

The mainstream chemiluminescence product in the market needs to adopt serum or plasma as a detection sample, can not support direct and automatic detection of a whole blood sample, has long first sample report time and long total diagnosis time, hardly meets the requirement of detection turnover time, has long total waiting time, can aggravate the pain of a patient, easily causes the conflict emotion of family members or the patient, and is not beneficial to the treatment of subsequent patients.

In chinese patent document CN111735978A, a full-automatic chemiluminescence immunoassay analyzer is disclosed, which comprises a base, on which a reaction cup loading module, a mechanical arm sample introduction module, an incubation module, a mechanical arm and transfer module, a magnetic separation cleaning module and a detection module are integrally provided, which are independent of each other: the reaction cup loading module is used for carrying the reaction cup to a preset position, so that the mechanical arm sample introduction module can respectively add a reaction reagent and a sample into the reaction cup; the manipulator and the transfer module clamp the reaction cup into the incubation module to incubate the reaction cup; the reaction cup in the incubation module is clamped by the manipulator and the transfer module to the magnetic separation cleaning module for cleaning, and the cleaned reaction cup is clamped by the manipulator and the transfer module to the detection module for detection. The detailed structure of the related specific module is specifically disclosed, but the full-automatic chemiluminescence immunoassay analyzer in the technical scheme is not ideal in the specific use process; the overall structural layout and part of module structures of the instrument are not optimized enough, and the user experience is not good enough.

Disclosure of Invention

The technical problem to be solved by the invention is to provide a full-automatic chemiluminescence immunoassay analyzer, each module can be independently operated and used, the combination is flexible, the functions are various, the full-automatic chemiluminescence immunoassay analyzer can be adapted to different types of analyzers, the structural layout is more reasonable, and the user experience effect is good.

In order to solve the technical problems, the technical scheme adopted by the invention is that the full-automatic chemiluminescence immunoassay analyzer comprises a reaction cup loading module, a sample loading module, a kit loading module, a detection module and a magnetic separation cleaning module which are integrated and arranged on a base and are mutually independent;

the sample loading module comprises a sample box loading module and a chip loading module, wherein the sample box loading module is provided with a sample box, and the chip loading module is provided with a chip;

the kit loading module is used for storing reaction reagents;

the reaction cup loading module is used for carrying the reaction cup to a preset position, so that the sample in the sample loading module and the reaction reagent in the kit loading module are respectively added into the reaction cup;

the magnetic separation cleaning module is used for cleaning a reaction cup added with a sample and a reaction reagent, and the cleaned reaction cup is transferred to the detection module for detection;

the reaction cup loading module, the sample loading module and the kit loading module are all positioned at the front end region of the analyzer; the detection module and the magnetic separation cleaning module are both positioned at the rear end region of the analyzer.

By adopting the technical scheme, all the module components are integrated on the base to form a whole set of equipment, the structure is integrated, the streamlined operation is realized, the test time is short, and the using effect is good; each module can be independently operated and used, the combination is flexible, the functions are various, the device can be adapted to different types of analytical instruments, the detection efficiency is high, and the result is accurate and stable; in addition, the placement positions of the modules are optimized, and the reaction cup loading module, the sample loading module and the kit loading module are all positioned in the front end region of the analyzer, so that the operation and observation are facilitated; the detection module and the magnetic separation cleaning module are both located in the rear end region of the analyzer, different operation times are staggered, efficiency is improved, the pollution-free degree of the rear end region is relatively higher, the structural layout is more reasonable, and the user experience effect is good.

Preferably, the analyzer further comprises a mechanical arm sample introduction module, an incubation module and a mechanical arm transfer module;

the manipulator transferring module clamps a reaction cup added with a sample and a reaction reagent into the incubation module, and performs incubation reaction on the reaction cup;

the reaction cup in the incubation module is clamped by the manipulator transfer module again to the magnetic separation cleaning module for cleaning, and the cleaned reaction cup is clamped by the manipulator transfer module to the detection module for detection;

the mechanical arm sample introduction module is positioned in the upper end area of the analyzer and controls the actions of a sample sampling needle device for moving samples and a reagent sampling needle device for moving reaction reagents.

A manipulator transfer module (which can adopt a manipulator and a transfer module disclosed in the prior art Chinese patent document CN111735978A or other structures disclosed in the prior art) is used for transferring in the reaction cup detection process, the detection time can be reduced by clamping and matching of the manipulator, and the manipulator can perform horizontal movement, rotary movement, up-and-down movement and telescopic movement of a clamping jaw and can perform efficient detection in a matching manner; according to the requirements, a plurality of manipulators and a plurality of transfer devices can be configured to connect all mutually independent module functional parts, and meanwhile, the instrument can also be configured with detection modules and process modules of various detection platforms to realize desktop assembly line type various detection by matching with the manipulators and the transfer modules; the arm advances a kind module (can adopt the arm that prior art chinese patent document CN111735978A disclosed advances a kind module, or other prior art disclosed structures), and advances a kind module with the arm and be located the upper end region of this analysis appearance, and the scope of control allotment is wider, also is convenient for observe, and structural layout is more reasonable, and user experience is effectual.

Preferably, the reaction cup loading module is provided with a reaction cup bin for accommodating the reaction cups, a reaction cup sliding control component is arranged below the reaction cup bin, and the reaction cup sliding control component controls the reaction cups in the reaction cup bin to slide into the reaction cup seats.

The reaction cup bin is used for storing the reaction cups as an easily-consumed product, the reaction cup bin filled with the reaction cups is placed into an instrument, the reaction cups can slide down from the reaction cup bin by means of self gravity, and the reaction cup slide-down control component is arranged below the reaction cup bin and used for controlling the reaction cups to slide down into the reaction cup seats.

Preferably, the reaction cup bin is provided with a plurality of mutually independent reaction cup storage chambers, and outlets of the reaction cup storage chambers face to the sliding surfaces of the reaction cups; the reaction cup sliding from the sliding surface of the reaction cup enters a sliding position of the reaction cup, and the reaction cup is blocked by two reaction cup baffle plates in the reaction cup bin; the reaction cup sliding control assembly controls the reaction cup baffle two assemblies to move, so that the reaction cup positioned at the reaction cup sliding position slides into the reaction cup seat.

The reaction cup in the reaction cup storage chamber firstly slides to the sliding surface of the reaction cup through the outlet of the reaction cup storage chamber, slides to the sliding position of the reaction cup from the sliding surface of the reaction cup, waits for the control action of the sliding control component of the reaction cup, and slides to the reaction cup seat from the sliding position of the reaction cup.

Preferably, the reaction cup baffle plate I component and the reaction cup baffle plate II component of the reaction cup sliding control component are matched to control the reaction cup to slide into the reaction cup seat.

A plurality of reaction cups slide down from the sliding surface of the reaction cup, and the reaction cups which slide down from the sliding position of the reaction cups to the reaction cup seat need to be carried out one by one, so that a reaction cup baffle plate assembly is required to be matched with a reaction cup baffle plate assembly; the reaction cup baffle plate component is used for separating the lowermost reaction cup from other reaction cups, and the reaction cup baffle plate component enables the lowermost reaction cup to slide into the reaction cup seat from the reaction cup falling position.

Preferably, the reaction cup baffle plate II component consists of a spring and a reaction cup baffle plate II; the reaction cup sliding control component comprises a reaction cup sliding support plate, the reaction cup sliding support plate is fixedly connected with a reaction cup baffle I in the reaction cup baffle I component, and a reaction cup sliding push block is further arranged on the reaction cup sliding support plate; the reaction cup sliding support plate can drive the first reaction cup baffle and the first reaction cup sliding push block to move along the telescopic direction of the spring.

The reaction cup sliding push block is used for pushing the reaction cup baffle II, and the compression springs move in the same direction; the reaction cup baffle plate I is used for separating the lowermost reaction cup from other reaction cups; the reaction cup sliding support plate is fixedly connected with the reaction cup baffle plate I, and the reaction cup sliding support plate is further provided with a reaction cup sliding push block, so that the reaction cup baffle plate I and the reaction cup sliding push block are guaranteed to move synchronously.

Preferably, the reaction cup bin is provided with a reaction cup bin support, the reaction cup bin support is provided with a reaction cup bin support through hole, and the first reaction cup baffle plate penetrates through the reaction cup bin support through hole to block the reaction cup; the reaction cup sliding support plate is provided with a guide groove, and a guide rail positioned at the bottom of the reaction cup bin support is in sliding connection with the guide groove; through setting up guide rail, guide way for reaction cup landing extension board removes stably.

Preferably, a reaction cup sliding bottom plate is further arranged on the outer side of the reaction cup sliding control assembly, and the reaction cup seat is arranged at the front end of the reaction cup sliding bottom plate; a reaction cup sliding motor is arranged on the reaction cup sliding bottom plate and drives an eccentric shaft connected with a motor shaft connecting block to rotate; and an eccentric shaft limiting groove is formed in the bottom surface of the reaction cup sliding support plate, and the eccentric shaft moves in the eccentric shaft limiting groove and drives the reaction cup sliding support plate to move.

Through the structural arrangement of the eccentric shaft and the eccentric shaft limiting groove, the reaction cup sliding motor drives the reaction cup sliding support plate to reciprocate back and forth along the guide rail at the bottom of the two reaction cup baffle components.

Preferably, the first reaction cup baffle plate is fixedly connected with the reaction cup sliding support plate through a reaction cup baffle plate support plate in the first reaction cup baffle plate assembly; a limiting structure is arranged behind the reaction cup sliding support plate and is matched with a limiting optocoupler at the bottom of the reaction cup bin support for limiting; the limiting structure is used for limiting the movement of the reaction cup sliding support plate.

Preferably, the reaction cup loading module further comprises a reaction cup carrying device, the reaction cup carrying device is provided with a movable reaction cup carrying seat, and a reaction cup seat pushing handle is arranged on the reaction cup carrying seat; the reaction cup seat pushing handle can push the reaction cup seat to rotate around the rotating shaft, so that the reaction cup in the reaction cup seat is changed from a lying position to a standing position, and the reaction cup slides into the reaction cup carrying seat from the inside of the reaction cup seat; the reaction cup carrying seat carries the reaction cup to a preset position, after a sample and a reaction reagent are added, the manipulator transferring module clamps the reaction cup added with the sample and the reaction reagent into the incubation module, and the reaction cup is incubated.

Preferably, the reaction cup carrying device is further provided with a reaction cup carrying motor, the reaction cup carrying motor drives a reaction cup carrying screw rod to rotate, and a reaction cup carrying screw rod nut positioned on the reaction cup carrying screw rod is connected with the reaction cup carrying seat; the reaction cup carrying screw rod nut is further connected with a reaction cup carrying sliding block, and the reaction cup carrying sliding block drives the reaction cup carrying seat to move along the reaction cup carrying sliding rail.

Preferably, the sample box loading module is provided with a sample box bin, a plurality of limiting rails are arranged in the sample box bin, and the limiting rails are matched with limiting grooves in the bottom surface of the sample box for limiting; and the top end of the sample box is provided with a sample box positioning structure which is matched with a limiting ball plunger of the sample box bin for limiting.

Preferably, a reaction cup waste groove is arranged below the sample box bin and is used for collecting waste after the detection of the reaction cup is finished; and a sample box handle is further arranged at one end of the sample box, which is far away from the sample box positioning structure.

Preferably, the chip loading module comprises a chip bin, and a plurality of chips are stacked in the chip bin; the chip carrying device also comprises a chip carrying groove, and the front end of the chip carrying groove in the moving direction is positioned below the chip bin; the chip carrying groove carries the chip to a chip pressure device, a sample feeding cavity of the chip is pressurized, and whole blood sample filtration is carried out; the sample sampling needle device sucks up the plasma/serum sample flowing into the chip sampling pool.

The front end of the chip carrying groove in the moving direction is positioned below the chip bin, namely when the chip is initially carried, the chip positioned at the lowest part in the chip bin enters the chip carrying groove, and the chip is carried to the chip pressure device by the chip carrying groove.

Preferably, a sampling top plate is further arranged at a position close to the chip pressure device, and a sampling port is formed in the sampling top plate; the sample sampling needle device draws a plasma/serum sample through the sampling port.

Set up the sampling roof, have the effect that prevents the chip pollution, in addition, have the sample connection on the sampling roof, absorb plasma/serum sample more accurate.

Preferably, the chip pressure device is controlled by the chip pressure device movement motor to move up and down; the chip pressure device is provided with an air pressure interface, and the chip pressurizes the sample injection cavity through the external connection of the air pressure interface.

Preferably, a first chip carrying groove fixing plate and a second chip carrying groove fixing plate are respectively arranged at the front end and the rear end of the chip carrying groove; and a chip carrying groove support plate is arranged below the chip carrying groove and used for supporting the chip.

The chip carrying groove is connected with other parts through a first chip carrying groove fixing plate and a second chip carrying groove fixing plate; the chip carrying groove support plate enables the chip carrying groove to be supported in the moving direction.

Preferably, a chip motion motor drives the chip carrying groove to move and convey the chip to a sampling position; the chip moving motor drives the chip moving driving wheel to rotate, the chip moving belt I drives the chip moving driven wheel I to move, so that the chip moving driven wheel II is driven to move, the chip moving belt II drives the chip moving driven wheel III to move, the chip moving belt II bypasses the chip carrying groove support plate and the chip moving driven wheel IV, is fixedly connected with the chip carrying groove and then is connected with the chip moving driven wheel V, and belt transmission is realized; and the second chip moving belt is fixedly connected with the chip carrying groove through the first chip carrying groove fixing plate and the second chip carrying groove fixing plate.

Preferably, a chip discard passage is provided at a front end position of the chip carrying groove support plate along a moving direction of the chip carrying groove, and a chip discard groove is provided below the chip discard passage.

After sampling, the chip continues to move, and when the chip moves to the lower part without a chip carrying groove support plate, the chip enters a chip abandoning groove from the lower part of the carrying groove through a chip abandoning passage.

Preferably, the chip pressure device moving motor and the chip moving motor are arranged in an up-and-down stacked manner and are fixed on the chip loading module motor bracket; the chip pressure device is arranged between the chip bin and the chip loading module motor bracket; the chip waste groove is positioned on the side surfaces of the chip bin, the chip loading module motor support and the chip pressure device; by adopting the structure, the operation and the chip loading are convenient.

Preferably, the chip pressure device is arranged on a chip pressure device-slide block connecting block, and a chip pressure device-limiting structure is arranged on the chip pressure device-slide block connecting block; and a chip pressure device-sliding rail is arranged on the chip loading module motor support, and the chip pressure device-sliding block connecting block is fixedly connected with the chip pressure device-sliding block to drive the chip pressure device to move up and down along the chip pressure device-sliding rail.

Preferably, a chip pressure device-limiting groove is formed in the inner side of the chip pressure device-sliding block connecting block; the chip pressure device moving motor is connected with a chip pressure device-eccentric shaft, the chip pressure device-eccentric shaft moves in the chip pressure device-limiting groove and simultaneously drives a chip pressure device-slide block connecting block to move up and down along the chip pressure device-slide rail, so that the chip pressure device is driven to move, and air pressurization is carried out on the chip.

Preferably, the lower part of the chip carrying groove is hollowed, and the periphery of the inner side of the chip carrying groove is provided with an arc angle.

Preferably, the reagent box loading module is provided with a reagent box bin, a plurality of reagent boxes are placed in the reagent box bin, and each reagent box is provided with a magnetic bead reagent cup; the magnetic bead reagent cup is kept in a uniformly-mixed state of the magnetic bead reagent in the magnetic bead reagent cup by the reagent uniformly-mixing component.

Preferably, a plurality of reagent box limiting partitions II are arranged in the reagent box bin, and a reagent box placing space is formed between every two adjacent reagent box limiting partitions II.

Preferably, a partition limiting groove is arranged on the reagent kit limiting partition II, and a partition limiting lug is arranged on the reagent kit and is matched and limited with the partition limiting groove.

Preferably, the outer side of the reagent kit limiting partition II is also provided with a reagent kit limiting partition I.

Preferably, the kit is also provided with a kit limiting clamp, and the kit limiting clamp is provided with a kit limiting notch; the reagent box limiting notch can be matched with a reagent box limiting convex column on the reagent box bin to limit the reagent box.

Preferably, the lower part of the magnetic bead reagent cup is provided with a gear structure, the gear structure is meshed with a sawtooth structure on a mixing plate in the reagent mixing assembly, the sawtooth structure is close to one side of the reagent box bin, and the magnetic bead reagent cup is rotated through the reciprocating motion of the mixing plate, so that the mixing of reagents in the magnetic bead reagent cup is realized.

Preferably, a blending plate limiting column is arranged on the blending plate, a blending plate limiting block is arranged on the reagent box bin, and the blending plate limiting column is positioned in a blending plate limiting groove in the blending plate limiting block; the blending plate limiting block is also provided with a blending plate card combination groove which is used for clamping the blending plate.

Through mixing board spacing recess, mixing board card closes groove structure, makes the reciprocating linear motion that the mixing board can remain stable, makes the magnetic bead reagent can keep the mixing state.

Preferably, the mixing plate is provided with a reagent mixing limiting groove; the reagent blending assembly further comprises a reagent blending motor and a blending motor shaft connecting block, wherein a blending eccentric shaft is fixedly connected to the blending motor shaft connecting block, moves in the reagent blending limiting groove and drives the blending plate to reciprocate.

Preferably, the bottom of the reagent box bin is provided with a refrigerating sheet and a cooling fan; the temperature of the reagent using environment is ensured.

Preferably, the magnetic separation cleaning module comprises a cleaning needle movement assembly, and the cleaning needle movement assembly is provided with a magnetic separation cleaning motor, a magnetic separation cleaning screw rod and a magnetic separation cleaning screw rod nut connecting block; a cleaning liquid needle group mounting position is arranged on the magnetic separation cleaning screw rod nut connecting block; the magnetic separation cleaning motor drives the magnetic separation cleaning screw rod to rotate, so that the cleaning liquid needle group positioned at the mounting position of the cleaning liquid needle group can move up and down along the magnetic separation cleaning screw rod; the cleaning liquid needle group comprises a liquid inlet needle and a liquid discharge needle.

Preferably, partitions are arranged on two sides of the magnetic separation cleaning screw nut connecting block, and the magnetic separation cleaning screw nut connecting block is in contact with the partitions on the two sides of the magnetic separation cleaning screw nut connecting block, so that the magnetic separation cleaning screw nut connecting block moves up and down along the partitions; each magnetic separation cleaning screw nut connecting block is contacted with the partitions on the two sides of the magnetic separation cleaning screw nut connecting block, so that the magnetic separation cleaning screw nut connecting blocks move up and down.

Preferably, the magnetic separation cleaning module further comprises a magnetic separation seat, and the magnetic separation seat is provided with a plurality of reaction cup placing positions; the magnetic separation seat is controlled by a rotary motor of the magnetic separation seat to rotate, so that reaction cups on the magnetic separation seat are sequentially subjected to magnetic separation cleaning.

The magnetic separation seat rotating motor controls the magnetic separation seat to rotate, so that reaction cups on the magnetic separation seat are sequentially subjected to magnetic separation cleaning.

Preferably, the magnetic separation seat rotating motor is positioned at the bottom of the magnetic separation seat; the magnetic separation seat rotating motor and the magnetic separation seat are both arranged close to the magnetic separation cleaning installation plate and are positioned on the same side of the magnetic separation cleaning installation plate; the magnetic separation cleaning motor is arranged on the other side of the magnetic separation cleaning mounting plate, the partitions are arranged above the magnetic separation cleaning motor, and the magnetic separation cleaning screw nut connecting blocks and the magnetic separation cleaning screws are arranged in two adjacent partitions; by adopting the structural layout, the structure is compact, and the whole structure is simpler.

Preferably, each magnetic separation seat rotating motor individually controls one magnetic separation seat to rotate; each magnetic separation cleaning motor independently controls one magnetic separation cleaning screw rod nut connecting block to move up and down; the magnetic separation cleaning screw nut connecting block is connected to the magnetic separation cleaning screw nut and moves up and down along the partition; the mutual independent control, mutual noninterference, efficiency is higher.

Preferably, the detection module comprises a detection chamber, a PMT and a photon counter; and a detection reaction cup seat is arranged in the detection chamber, excitation liquid is added into a reaction cup of the detection reaction cup seat through an excitation liquid adding and waste liquid discharging needle set, waste liquid after reaction is sucked out through a liquid discharging needle in the excitation liquid adding and waste liquid discharging needle set, and the PMT and the photon counter perform optical detection on the reaction cup in sequence to obtain a detection result.

By adopting the structure, the filling of the exciting liquid and the discharge of waste liquid after reaction can be completed quickly and efficiently.

Preferably, the exciting liquid filling and waste liquid discharging needle group is controlled by an exciting liquid filling and waste liquid discharging needle group movement component to move up and down; the exciting liquid filling and waste liquid discharging needle set motion assembly is provided with an exciting liquid filling and waste liquid discharging needle set motion motor, and the exciting liquid filling and waste liquid discharging needle set motion motor is connected with an exciting liquid filling and waste liquid discharging needle set-eccentric shaft; the exciting liquid filling and waste liquid discharging needle set-eccentric shaft moves in the exciting liquid filling and waste liquid discharging needle set-limiting groove and simultaneously drives the exciting liquid filling and waste liquid discharging needle set-connecting block I to move up and down, and the exciting liquid filling and waste liquid discharging needle set-connecting block II is connected with the exciting liquid filling and waste liquid discharging needle set-connecting block I; two exciting liquid needle mounting positions and one liquid discharge needle mounting position are arranged on the exciting liquid filling and waste liquid discharge needle set-connecting block II, two guide positioning rod mounting positions are also arranged, and guide positioning rods are mounted on the guide positioning rod mounting positions.

Preferably, an excitation liquid filling and waste liquid discharging needle set-limiting structure is arranged above the excitation liquid filling and waste liquid discharging needle set-connecting block.

Preferably, the detection chamber is provided with a detection chamber baffle, the detection chamber baffle is controlled by a detection chamber baffle motor to move in a telescopic mode, the detection chamber baffle is provided with a reaction cup moving port, and the detection reaction cup seat is located below the detection chamber baffle.

When the reaction cup is clamped into the detection chamber, the baffle plate of the detection chamber extends out, the reaction cup moves from the reaction cup taking port on the baffle plate of the detection chamber to enter the detection reaction cup seat of the detection chamber, and the reaction cup is clamped into the reaction cup position of the detection reaction cup seat; the baffle of the detection chamber and the moving opening of the reaction cup are coincided or staggered with each other, and the detection chamber is opened or closed with each other.

Preferably, a reaction cup ejector rod is further arranged in the detection chamber, and when the reaction cup enters from the reaction cup moving and taking port, the reaction cup is received into the reaction cup position of the detection reaction cup seat by the reaction cup ejector rod.

Preferably, the detection reaction cup seat rotates under the control of a detection reaction cup seat rotating motor; the detection reaction cup seat rotating motor drives a detection reaction cup seat rotating driving wheel to rotate, and the detection reaction cup seat rotating driving wheel drives a detection reaction cup seat positioned at the bottom of the detection reaction cup seat to rotate and move from a driving wheel through a belt so as to drive the detection reaction cup seat to rotate; the detection reaction cup seat is provided with a plurality of reaction cup placing positions, and the detection reaction cup seat is rotated, so that more reaction cups can be clamped into the detection reaction cup seat of the detection chamber for detection.

Preferably, the reaction cup ejector rod is controlled by a reaction cup ejector rod motion motor to move up and down, the reaction cup ejector rod motion motor is connected with a reaction cup ejector rod-eccentric shaft, the reaction cup ejector rod-eccentric shaft is positioned in a reaction cup ejector rod-limiting groove of an ejector rod slide glass connecting block, and the ejector rod slide glass connecting block is fixedly connected with an ejector rod slide glass; correspondingly, one end of the carrier glass of the ejector rod is positioned in the ejector rod limiting structure.

The operation principle of the full-automatic chemiluminescence immunoassay analyzer is as follows: the reaction cup enters from the reaction cup loading module, and after the reaction cup carrying device brings the reaction cup to a designated position, the mechanical arm sample introduction module respectively adds a sample and a reaction reagent into the reaction cup; the manipulator transfer module clamps the reaction cup into the incubation module for incubation reaction, clamps the reaction cup into the magnetic separation cleaning module, uses the cleaning liquid needle group to suck and discharge the waste liquid which is not combined with the reaction cup in an unreacted manner, adds the cleaning liquid into the reaction cup for cleaning, uses the cleaning liquid needle group to suck and discharge the waste liquid again, repeats the operation for 3-5 times, clamps the reaction cup into the detection module by the manipulator transfer module after the cleaning is finished, adds the enhancement liquid and then carries out a light-resistant reaction, and detects the PMT and the photon counter; meanwhile, the instrument can be also provided with detection modules and process modules of various detection platforms, so that desktop assembly line type various detection is realized.

Drawings

The following further detailed description of embodiments of the invention is made with reference to the accompanying drawings:

FIG. 1 is a schematic perspective view of a full-automatic chemiluminescence immunoassay analyzer according to the present invention;

FIG. 2 is a schematic front view of the full-automatic chemiluminescence immunoassay analyzer in FIG. 1;

FIG. 3 is a schematic top view of the full-automatic chemiluminescence immunoassay analyzer of FIG. 1;

FIG. 4 is a diagram showing a reaction cuvette loading state of the reaction cuvette loading module of FIG. 1;

FIG. 5 is an enlarged partial schematic view of FIG. 4;

FIG. 6 is a structural view of the reaction cup loading module (removing the slide bottom plate of the reaction cup) in FIG. 1 in a state that the reaction cup is not loaded;

FIG. 7 is a block diagram of the reaction cup slip control assembly of FIG. 6;

FIG. 8 is a structural view of a cuvette carrier;

FIG. 9 is a block diagram of the cartridge loading module of FIG. 1;

FIG. 10 is a view of the interior of the sample cartridge magazine of the sample cartridge loading module of FIG. 9;

FIG. 11 is a schematic perspective view of a sample cell;

FIG. 12 is a block diagram of the chip loading module of FIG. 1;

FIG. 13 is a rear perspective view of the chip loading module of FIG. 12;

FIG. 14 is a schematic diagram of the chip loading module of FIG. 13 with the sampling top plate and the chip bin removed;

FIG. 15 is a perspective view of the chip carrier slot of FIG. 14;

FIG. 16 is a schematic diagram of a chip pressure device of the chip loading module of FIG. 12;

FIG. 17 is a schematic cross-sectional view of a chip loading module;

FIG. 18 is a schematic front perspective view of a cartridge loading module (with a cartridge assembled);

FIG. 19 is a schematic view of the back side perspective of the cartridge loading module (with the cartridge assembled);

FIG. 20 is a block diagram of the blending assembly of FIG. 18;

FIG. 21 is an enlarged partial schematic view of FIG. 20;

FIG. 22 is a schematic view of the structure of the kit;

FIG. 23 is a schematic view of a partially enlarged structure of the cartridge of FIG. 22;

FIG. 24 is a schematic view of a rear perspective of a cartridge loading module;

FIG. 25 is a schematic front perspective view of a cartridge loading module (unassembled cartridge);

FIG. 26 is a schematic view of a rear perspective of a cartridge loading module (unassembled cartridge);

FIG. 27 is a schematic perspective view of a magnetic separation cleaning module;

FIG. 28 is a schematic view of the magnetic separation cleaning module of FIG. 27 assembled with a detection module and a robot transfer module;

FIG. 29 is a schematic perspective view of the detection module of FIG. 1;

FIG. 30 is a schematic perspective view of the detection module (with the housing of the detection chamber removed);

FIG. 31 is a schematic diagram of a rear perspective view of the detection module of FIG. 29;

FIG. 32 is an enlarged partial schematic view of the detection module of FIG. 30;

wherein: 1-a base; 2-reaction cup loading module, 201-reaction cup bin, 20101-reaction cup bin bracket, 20102-reaction cup bin bracket through hole, 202-reaction cup slide control component, 20201-reaction cup baffle plate component I, 20202-reaction cup slide support plate, 20203-reaction cup baffle plate I, 20204-reaction cup slide pushing block, 20205-guide groove, 20206-eccentric shaft limit groove, 20207-reaction cup baffle plate, 20208-limit optical coupler, 203-reaction cup seat, 20301-rotating shaft, 204-reaction cup storage chamber, 205-reaction cup storage chamber outlet, 206-reaction cup slide surface, 207-reaction cup slide position, 208-reaction cup baffle plate component II, 20801-spring, 20802-reaction cup baffle plate II, 20803-limit structure, 209-reaction cup slide bottom plate, 2010-reaction cup sliding motor, 201001-motor shaft connecting block, 201002-eccentric shaft, 2011-reaction cup carrying device, 201101-reaction cup carrying seat, 201102-reaction cup seat pushing handle, 201103-reaction cup carrying motor, 201104-reaction cup carrying screw rod, 201105-reaction cup carrying screw rod nut, 201106-reaction cup carrying sliding block and 201107-reaction cup carrying sliding rail; 3-sample loading module, 301-sample cartridge loading module, 30101-sample cartridge, 30102-sample cartridge magazine, 30103-limit track, 30103-limit groove, 30104-sample cartridge positioning structure, 30105-limit ball plunger, 30106-reaction cup discard slot, 30107-sample cartridge handle, 302-chip loading module, 30201-chip, 30202-chip magazine, 30203-chip carrier slot, 30204-chip pressure device, 30205-sample cell, 30206-sample chamber, 30207-sample top plate, 30208-sample port, 30209-chip pressure device motion motor, 302010-air pressure interface, 302011-chip carrier slot mounting plate one, 302012-chip carrier slot mounting plate two, 302013-chip carrier slot mounting plate, 302014-chip motion motor, 302015-chip motion driving wheel, 302016-chip motion belt one, 302017-chip motion driven wheel one, 302018-chip motion driven wheel two, 302019-chip motion belt two, 302020-chip motion driven wheel three, 302021-chip motion driven wheel four, 302022-chip motion driven wheel five, 302023-chip waste passage, 302024-chip waste groove, 302025-chip loading module motor support, 302026-chip pressure device-slider connecting block, 302027-chip pressure device-limit structure, 302028-chip pressure device-slide rail, 302029-chip pressure device-slider, 302030-chip pressure device-limit groove, 302031-chip pressure device-eccentric shaft; 4-a kit loading module, 401-a kit bin, 40101-a kit, 40102-a magnetic bead reagent cup, 40103-a kit limit partition two, 40104-a kit placing space, 40105-a partition limit groove, 40106-a partition limit bump, 40107-a kit limit partition one, 40108-a kit limit clamp, 40109-a kit limit notch, 401010-a gear structure, 401011-a kit limit convex column, 402-a reagent blending component, 40201-a blending plate, 40202-a sawtooth structure, 40203-a blending plate limit column, 40204-a blending plate limit block, 40205-a blending plate limit groove, 40206-a blending plate engaging groove, 40207-a reagent blending limit groove, 40208-a reagent blending motor, 40209-a blending motor shaft connecting block, 402010-a blending eccentric shaft, 403-refrigeration sheet, 404-cooling fan; 5-detection module, 501-detection chamber, 50101-detection chamber baffle, 50102-detection chamber baffle motor, 50103-reaction cup moving port, 50104-reaction cup ejector pin, 50105-detection reaction cup holder rotating motor, 50106-detection reaction cup holder rotating driving wheel, 50107-detection reaction cup holder rotating driven wheel, 50108-reaction cup ejector pin moving motor, 50109-reaction cup ejector pin-eccentric shaft, 501010-ejector pin slide connecting block, 501011-reaction cup ejector pin-limit groove, 501012-ejector pin slide, 501013-ejector pin limit structure, 501014-detection reaction cup holder, 502-PMT, 503-photon counter, 504-excitation liquid and waste liquid discharge needle set, 505-excitation liquid and waste liquid discharge needle set moving component, 50501-excitation liquid injection and waste liquid discharge needle set moving motor, 50502-exciting liquid filling and waste liquid discharging needle set-eccentric shaft, 50503-exciting liquid filling and waste liquid discharging needle set-limit groove, 50504-exciting liquid filling and waste liquid discharging needle set-connecting block I, 50505-exciting liquid filling and waste liquid discharging needle set-connecting block II, 50506-exciting liquid needle mounting position, 50507-liquid discharging needle mounting position, 50508-guiding locating rod mounting position, 50509-guiding locating rod, and 505010-exciting liquid filling and waste liquid discharging needle set-limit structure; 6-magnetic separation cleaning module, 601-cleaning needle motion assembly, 60101-magnetic separation cleaning motor, 60102-magnetic separation cleaning screw rod, 60103-magnetic separation cleaning screw rod nut connecting block, 60104-cleaning liquid needle set installation position, 60105-cleaning liquid needle set, 60106-partition, 602-magnetic separation seat, 60201-reaction cup placement position, 60202-magnetic separation seat rotating motor and 603-magnetic separation cleaning installation plate; 7-reaction cup; 8-the front end region; 9-rear end region; 11-a mechanical arm sample introduction module; 12-an incubation module; 13-a manipulator transfer module; 14-upper end region; 15-a sample sampling needle device; 16-a reagent sampling needle device; 17-sampling plate, 1701-sampling plate through hole; and 18-washing the pool.

Detailed Description

As shown in fig. 1-3, the full-automatic chemiluminescence immunoassay analyzer of the embodiment comprises a reaction cup loading module 2, a sample loading module 3, a kit loading module 4, a detection module 5 and a magnetic separation cleaning module 6 which are integrated and arranged on a base 1 and are mutually independent;

the sample loading module 3 comprises a sample box loading module 301 and a chip loading module 302, wherein the sample box loading module 301 is provided with a sample box 30101, and the chip loading module 302 is provided with a chip 30201;

the kit loading module 4 is used for storing reaction reagents; the reaction cup loading module 2 is used for carrying the reaction cup 7 to a preset position, so that the reaction reagent in the reagent box loading module 4 and the sample in the sample loading module 3 are respectively added into the reaction cup 7;

the magnetic separation cleaning module 6 is used for cleaning the reaction cup 7 added with the sample and the reaction reagent, and the cleaned reaction cup 7 is transferred to the detection module 5 for detection;

the reaction cup loading module 2, the sample loading module 3 and the reagent box loading module 4 are all positioned at the front end region 8 of the analyzer; the detection module 5 and the magnetic separation and cleaning module 6 are both located in the rear region 9 of the analyzer.

It should be noted that the analyzer in this embodiment further includes a manipulator sample injection module 11, an incubation module 12, and a manipulator transfer module 13 (having two manipulators and a transfer device), and the structures of the three are described in detail in the prior art (for example, chinese patent document CN 111735978A);

the manipulator transferring module 13 clamps the reaction cup 7 with the sample and the reaction reagent added into the incubation module 12, and performs incubation reaction on the reaction cup 7;

the reaction cup 7 in the incubation module 12 is clamped by the manipulator transfer module 13 again to the magnetic separation cleaning module 6 for cleaning, and the cleaned reaction cup 7 is clamped by the manipulator transfer module 13 to the detection module 5 for detection;

the mechanical arm sample introduction module 11 is located in an upper end region 14 of the analyzer, and controls the actions of a sample sampling needle device 15 for transferring a sample and a reagent sampling needle device 16 for transferring a reaction reagent (the sample sampling needle device 15 and the reagent sampling needle device 16 also belong to the prior art and are disclosed in chinese patent document CN 111735978A); in this embodiment, as shown in fig. 1, a sampling plate 17 is further provided, the sampling plate 17 has a sampling plate through hole 1701 (the sample sampling needle of the sample sampling needle device 15 and the reagent sampling needle of the reagent sampling needle device 16 are sampled through the sampling plate through hole 1701), a cleaning tank 18 is mounted on the sampling plate 17, and the cleaning tank 18 is used for cleaning the sample sampling needle of the sample sampling needle device 15 and the reagent sampling needle of the reagent sampling needle device 16.

The reaction cup loading module 2 has a reaction cup bin 201 for accommodating reaction cups, as shown in fig. 4-8, a reaction cup slide control assembly 202 is disposed below the reaction cup bin 201, and the reaction cup slide control assembly 202 controls the reaction cups 7 in the reaction cup bin 201 to slide into the reaction cup seats 203.

The reaction cup storage 201 has a plurality of independent reaction cup storage chambers 204, as shown in fig. 4 and 6, the reaction cup storage chamber outlet 205 of the reaction cup storage chamber 204 faces the reaction cup sliding surface 206; the reaction cup 7 sliding down from the reaction cup sliding surface 206 enters the reaction cup sliding position 207, and the reaction cup is blocked by the reaction cup baffle plate II component 208 in the reaction cup bin 201; the reaction cup slide control assembly 202 controls the reaction cup baffle plate assembly 208 to move, so that the reaction cup 7 located in the reaction cup slide position 207 slides into the reaction cup seat 203.

The reaction cup baffle plate assembly 20201 of the reaction cup slide control assembly 202 cooperates with the reaction cup baffle plate assembly 208 to control the reaction cup 7 to slide into the reaction cup seat 203.

The reaction cup baffle plate II assembly 208 is composed of a spring 20801 and a reaction cup baffle plate II 20802, as shown in FIG. 6; the reaction cup sliding control assembly 202 comprises a reaction cup sliding support plate 20202, the reaction cup sliding support plate 20202 is fixedly connected with a reaction cup baffle plate I20203 in the reaction cup baffle plate assembly 20201, and a reaction cup sliding push block 20204 is further arranged on the reaction cup sliding support plate 20202; the reaction cup sliding support plate 20204 can drive the reaction cup baffle plate 20203 and the reaction cup sliding push block 20204 to move along the telescopic direction of the spring 20801.

The reaction cup bin 201 is provided with a reaction cup bin bracket 20101, the reaction cup bin bracket 20101 is provided with a reaction cup bin bracket through hole 20102, and a reaction cup baffle plate I20203 penetrates through the reaction cup bin bracket through hole 20102 to block the reaction cup; the reaction cup sliding support plate 20204 is provided with a guide groove 20205, and a guide rail (not shown in the figure) positioned at the bottom of the reaction cup bin bracket 20101 is in sliding connection with the guide groove 20205.

A reaction cup sliding bottom plate 209 is also arranged at the outer side of the reaction cup sliding control assembly 202, and a reaction cup seat 203 is arranged at the front end of the reaction cup sliding bottom plate 209; a reaction cup slipping motor 2010 is arranged on the reaction cup slipping bottom plate 209, and the reaction cup slipping motor 2010 drives an eccentric shaft 201002 connected with a motor shaft connecting block 201001 to rotate; an eccentric shaft limiting groove 20206 is formed in the bottom surface of the reaction cup sliding support plate 20202, and the eccentric shaft 201002 moves in the eccentric shaft limiting groove 20206 and drives the reaction cup sliding support plate 20202 to move, as shown in fig. 7.

The first reaction cup baffle 20203 is fixedly connected with the second reaction cup slide support plate 20202 through a first reaction cup baffle support plate 20207 in a first reaction cup baffle assembly 20201, as shown in fig. 5; a limiting structure 20803 is arranged behind the reaction cup sliding support plate 20202 and is matched with a limiting optocoupler 20208 at the bottom of the reaction cup bin support 20101 for limiting, as shown in FIG. 6.

As shown in fig. 8, the cuvette loader module 2 of the present embodiment further includes a cuvette carrier 2011, the cuvette carrier 2011 has a movable cuvette carrier 201101, and the cuvette carrier 201101 is provided with a cuvette carrier pusher 201102; the reaction cup holder pushing handle 201102 can push the reaction cup holder 203 to rotate around the rotating shaft 20301 so that the reaction cup 7 in the reaction cup holder 203 changes from a lying position to a standing position, and thus the reaction cup 7 slides down from the reaction cup holder 203 to the reaction cup carrier 201101; the cuvette carrier 201101 carries the cuvette to a preset position, and after the sample and the reagent are added, the manipulator transfer module 13 clamps the cuvette 7 with the sample and the reagent to the incubation module 12, so as to perform incubation reaction on the cuvette 7.

The reaction cup carrying device 2011 is also provided with a reaction cup carrying motor 201103, the reaction cup carrying motor 201103 drives the reaction cup carrying lead screw 201104 to rotate, and a reaction cup carrying lead screw nut 201105 positioned on the reaction cup carrying lead screw 201104 is connected with the reaction cup carrying seat 201101; the reaction cup carrying lead screw nut 201105 is further connected with a reaction cup carrying slide 201106, and the reaction cup carrying seat 201101 is driven to move along the reaction cup carrying slide rail 201107 through the reaction cup carrying slide 201106.

Specifically, the cuvette loader module 2 functions to transfer the cuvette 7 to the cuvette holder 203. Then the reaction cup carrying device 2011 carries and moves the reaction cup 7 to a preset position, and the mechanical arm sample introduction module 11 respectively adds a sample and a reaction reagent into the reaction cup 7 through the sample sampling needle device 15 and the reagent sampling needle device 16; and then, the first manipulator of the manipulator transferring module 13 transfers the reaction cup 7 to the incubation module 12, after incubation reaction, the first manipulator transfers the reaction cup 7 to the magnetic separation cleaning module 6 for magnetic separation cleaning, the cleaned reaction cup 7 is transferred to a transferring device of the manipulator transferring module 13 by the first manipulator, then the second manipulator of the manipulator transferring module 13 transfers the reaction cup 7 to the detection module 5, excitation liquid is added for light-shielding reaction, and a detection result is obtained through optical detection. The detected cuvette 7 is transferred by the second robot to the cuvette discard slot 30106 provided at the bottom of the cartridge loading module 301.

When the reaction cup is loaded, the reaction cup sliding motor 2010 is started to drive the reaction cup sliding support plate 20202 to move towards the outer side of the analyzer in the embodiment, the reaction cup sliding support plate 20202 is fixedly connected with the first reaction cup baffle 20203, the reaction cup sliding push block 20204 is also fixedly connected with the reaction cup sliding support plate 20202, the reaction cup to be slid is located between the first reaction cup baffle 20203 and the second reaction cup baffle 20802, and the reaction cup sliding support plate 20202 is provided with a reaction cup sliding position 207. The reaction cup sliding support plate 207 drives the first reaction cup baffle 20203 and the second reaction cup sliding push block 20204 to move in the same direction, the first reaction cup baffle 20203 penetrates through the through hole 20102 of the reaction cup bin support to block other reaction cups, the second reaction cup baffle 20802 is pushed by the second reaction cup sliding push block 20204, and the compression spring 20801 moves in the same direction, so that the lowermost reaction cup slides down from the reaction cup sliding position 207, and the lower reaction cup sliding bottom plate 209 supports the reaction cups.

When the reaction cup is not loaded, the reaction cup sliding motor 2010 is started, the motor shaft rotates reversely, the first reaction cup baffle 20203 and the second reaction cup sliding push block 20204 move towards the inside of the instrument, the second reaction cup baffle 20802 moves under the stretching action of the spring 20801 to block the reaction cup from sliding to the reaction cup sliding position 207, the reaction cup sliding position 207 moves to the position right facing the reaction cup seat 203, the reaction cup slides to the reaction cup seat 203, and the reaction cup seat 203 is at the lying position.

Reaction cup carrying motor 201103 starts, and its driving wheel of connecting passes through the belt and drives the driven wheel rotation to reaction cup carrying lead screw 201104 rotates, and reaction cup carrying lead screw nut 201105 is connected with reaction cup carrying seat 201101, and reaction cup carrying lead screw nut 201105 is connected with reaction cup carrying slider 201106, drives reaction cup carrying seat 201101 through reaction cup carrying slider 201106 and carries slide rail 201107 motion along the reaction cup. The reaction cup carrier 201101 is provided with a reaction cup holder pusher 201102 which can push the reaction cup holder 203 to change from a lying position to a standing position around the rotating shaft 20301, so that the reaction cup slides into the reaction cup carrier 201101 and is carried to a preset position, and after a sample and a reaction reagent are added, the reaction cup is clamped by a manipulator to be transferred to the reaction cup incubation module 12 for incubation reaction.

As shown in fig. 9-11, the sample cartridge loading module 301 has a sample cartridge magazine 30102, a plurality of limiting rails 30108 are disposed in the sample cartridge magazine 30102, and the limiting rails 30108 are engaged with the limiting grooves 30103 on the bottom surface of the sample cartridge 30101 for limiting; the top end of the sample box 30101 is provided with a sample box positioning structure 30104, which is matched with a limit ball plunger 30105 of the sample box cabin 30102 for limiting.

A reaction cup waste groove 30106 is arranged below the sample box cabin 30102 and used for collecting waste after the reaction cup detection is finished; a cartridge handle 30107 is also provided on the cartridge 30101 at the end remote from the cartridge positioning structure 30104, as shown in fig. 11. In use, a plasma/serum sample is added to the cartridge.

The chip loading module comprises a chip bin 30202, as shown in fig. 12 to 17, a plurality of chips 30201 are stacked in the chip bin 30202; the chip carrier is characterized by further comprising a chip carrier groove 30203, wherein the lower part of the chip carrier groove 30203 is hollowed out, and the periphery of the inner side of the chip carrier groove 30203 is provided with arc angles; the front end of the chip carrier groove 30203 in the direction of movement is located below the chip bin 30202; the chip carrier 30203 carries the chip 30201 to the chip pressure device 30204, and pressurizes the sample injection chamber 30206 of the chip 30201 to filter the whole blood sample; the sample sampling needle device 15 aspirates the plasma/serum sample flowing into the chip sampling cell 30205.

A sampling top plate 30207 is also arranged at a position adjacent to the chip pressure device 30204, and the sampling top plate 30207 is provided with a sampling port 30208; the sample sampling needle assembly 15 draws a plasma/serum sample through the sampling port 30208.

The chip pressure device 30204 is controlled to move up and down by the chip pressure device moving motor 30209; the chip pressure device 30204 is provided with an air pressure interface 302010, and the chip 30201 pressurizes the sample injection cavity 30206 through an external air pressure interface 302010.

A first chip carrier slot fixing plate 302011 and a second chip carrier slot fixing plate 302012 are respectively arranged at the front end and the rear end of the chip carrier slot 30203; a chip carrier tray 302013 is also provided under the chip carrier tray 30203 for supporting the chip 30201.

As shown in fig. 16 and 17, the chip carrier 30203 is moved by the chip movement motor 302014 and the chip 30201 is transported to the sampling position; the chip moving motor 302014 drives the chip moving driving wheel 302015 to rotate, the chip moving driven wheel I302017 is driven to move through the chip moving belt I302016, so that the chip moving driven wheel II 302018 is driven to move, the chip moving driven wheel III 302020 is driven to move through the chip moving belt II 302019, the chip moving belt II 302019 bypasses the chip carrying groove support plate 302013 and the chip moving driven wheel IV 302021, is fixedly connected with the chip carrying groove 30203 and is connected with the chip moving driven wheel V302022, and belt transmission is achieved; the second chip moving belt 302019 is fixedly connected to the chip carrier groove 30203 by the first chip carrier groove securing plate 302011 and the second chip carrier groove securing plate 302012.

A chip discarding path 302023 is provided at a front end position of the chip carrier tray 302013 along the moving direction of the chip carrier 30203, and a chip discarding groove 302024 is provided below the chip discarding path 302023, as shown in fig. 13 and 14.

After the chip 30201 has been sampled, the movement is continued, and when the chip 30201 has moved to the position where the chip carrier tray 302013 is not present, the chip 30201 moves from the position below the chip carrier tray 30203 through the chip discard path 302023 and into the chip discard slot 302024.

The chip pressure device motion motor 30209 and the chip motion motor 302014 are arranged in an up-and-down stacked manner and are fixed on the chip loading module motor support 302025; a die pressure device 30204 is disposed between the die paddle 30202 and the die load module motor mount 302025; the chip reject slot 302024 is located at the side of the chip bin 30202, the chip load module motor mount 302025, and the chip pressure device 30204.

As shown in fig. 16, a die pressure device 30204 is disposed on the die pressure device-slider connection block 302026, and a die pressure device-stopper structure 302027 is disposed on the die pressure device-slider connection block 302026; a chip pressure device-slide rail 302028 is disposed on the chip loading module motor support 302025, and the chip pressure device-slide block connection block 302026 is fixedly connected to the chip pressure device-slide block 302029 to drive the chip pressure device 30204 to move up and down along the chip pressure device-slide rail 302028.

A chip press-stopper groove 302030 is provided on the inner side of the chip press-slider connection block 302026, as shown in fig. 17; the chip press motion motor 30209 is connected to a chip press-eccentric shaft 302031, and the chip press-eccentric shaft 302031 moves in the chip press-limit groove 302030, and at the same time, drives the chip press-slider connecting block 302026 to move up and down along the chip press-slide rail 302028, thereby driving the chip press 30204 to move, and thus, the chip 30201 is pressurized with air.

As shown in fig. 18-26, the reagent cartridge loading module 4 has a reagent cartridge bay 401, and a number of reagent cartridges 40101, each having a magnetic bead reagent cup 40102 therein, are placed in the reagent cartridge bay 401; the magnetic bead reagent cup 40102 is kept in a uniform mixing state of the magnetic bead reagent therein by the reagent uniform mixing component 402, and the magnetic bead reagent needs to be kept in a uniform mixing state, so that the magnetic bead reagent is prevented from sinking to influence the detection effectiveness.

A plurality of reagent box limiting partitions II 40103 are arranged in the reagent box bin 401, and a reagent box placing space 40104 is formed between every two adjacent reagent box limiting partitions II 40103; a partition limiting groove 40105 is formed in the reagent kit limiting partition II 40103, and a partition limiting bump 40106 and the partition limiting groove 40105 are assembled and limited in the reagent kit 40101; the outer side of the reagent kit limiting partition wall II 40103 is also provided with a reagent kit limiting partition wall I40107, as shown in figure 18.

A kit limit clamp 40108 is further arranged on the kit 40101, and the kit limit clamp 40108 is provided with a kit limit notch 40109; the reagent box limiting notch 40109 can be matched with the reagent box limiting convex column 401011 on the reagent box bin 401 to limit the reagent box 40101. Two kit limit notches 40109 of the kit 40101 monomer are respectively matched with the two kit limit convex columns 401011 to limit the kit 40101.

As shown in FIGS. 22 and 23, the magnetic bead reagent cup 40102 has a gear structure 401010 at the bottom, the gear structure 401010 is engaged with a saw tooth structure 40202 on the mixing plate 40201 of the reagent mixing module 402 near the cartridge compartment 401, and the magnetic bead reagent cup 40102 is rotated by the reciprocating motion of the mixing plate 40201, thereby mixing the reagents inside the magnetic bead reagent cup 40102.

A blending plate limiting column 40203 is arranged on the blending plate 40201, a blending plate limiting block 40204 is arranged on the reagent box bin 401, and the blending plate limiting column 40203 is positioned in a blending plate limiting groove 40205 in the blending plate limiting block 40204; the blending plate limiting block 40204 is further provided with a blending plate locking groove 40206, and the blending plate locking groove 40206 is used for locking the blending plate 40201.

A reagent blending limit groove 40207 is arranged on the blending plate 40201; as shown in fig. 19 and 26, the reagent blending assembly 402 further includes a reagent blending motor 40208 and a blending motor shaft connecting block 40209, a blending eccentric shaft 402010 is fixedly connected to the blending motor shaft connecting block 40209, and the blending eccentric shaft 402010 moves in the reagent blending limiting groove 40207 and drives the blending plate 40201 to reciprocate.

The bottom of the reagent box compartment 401 is provided with a cooling plate 403 and a cooling fan 404, as shown in fig. 24.

As shown in fig. 27 and 28, the magnetic separation cleaning module 6 includes a cleaning needle moving assembly 601, the cleaning needle moving assembly 601 has a magnetic separation cleaning motor 60101, a magnetic separation cleaning screw 60102 and a magnetic separation cleaning screw nut connecting block 60103; a cleaning liquid needle group installation position 60104 is arranged on the magnetic separation cleaning screw rod nut connecting block 60103; the magnetic separation cleaning motor 60101 drives the magnetic separation cleaning screw 60102 to rotate, so that the cleaning liquid needle set 60105 located at the cleaning liquid needle set installation position 60104 can move up and down along the magnetic separation cleaning screw 60102; cleaning solution needle set 60105 includes a liquid inlet needle and a liquid discharge needle.

Partitions 60106 are arranged on two sides of the magnetic separation cleaning lead screw nut connecting block 60103, and the magnetic separation cleaning lead screw nut connecting block 60103 is in contact with the partitions 60106 on the two sides, so that the magnetic separation cleaning lead screw nut connecting block 60103 moves up and down along the partitions 60106.

The magnetic separation cleaning module 6 also comprises a magnetic separation seat 602, and the magnetic separation seat 602 is provided with a plurality of reaction cup placing positions 60201; the rotation of the magnetic separating base 602 is controlled by a magnetic separating base rotating motor 60202 to perform magnetic separation and cleaning of the reaction cups on the magnetic separating base 602 in sequence.

The magnetic separation seat rotating motor 60202 is positioned at the bottom of the magnetic separation seat 602; the magnetic separation seat rotating motor 60202 and the magnetic separation seat 602 are both installed close to the magnetic separation cleaning installation plate 603 and are positioned on the same side of the magnetic separation cleaning installation plate 603; a magnetic separation cleaning motor 60202 is arranged on the other side of the magnetic separation cleaning mounting plate 603, the partition 60106 is arranged above the magnetic separation cleaning motor 60202, and a magnetic separation cleaning screw nut connecting block 60103 and a magnetic separation cleaning screw 60102 are arranged in two adjacent partitions 60106.

Each magnetic separation seat rotating motor 60202 individually controls one magnetic separation seat 602 to rotate; each magnetic separation cleaning motor 60202 individually controls one magnetic separation cleaning screw nut connecting block 60103 to move up and down; the magnetic separation cleaning screw nut connecting block 60103 is connected to the magnetic separation cleaning screw nut and moves up and down along the partition 60106.

The detection module 5 has a detection chamber 501, a PMT 502, and a photon counter 503, as shown in fig. 29-32; a detection reaction cup seat 501014 is arranged in the detection chamber 501, the excitation liquid filling and waste liquid discharging needle group 504 adds the excitation liquid into the reaction cup of the detection reaction cup seat 501014, the waste liquid after reaction is sucked out through the excitation liquid filling and waste liquid discharging needles in the waste liquid discharging needle group 504, and the PMT 502 and the photon counter 503 sequentially perform optical detection on the reaction cup to obtain a detection result.

The excitation liquid filling and waste liquid discharging needle set 504 is controlled by an excitation liquid filling and waste liquid discharging needle set movement component 505 to move up and down; the excitation liquid filling and waste liquid discharging needle group motion assembly 505 is provided with an excitation liquid filling and waste liquid discharging needle group motion motor 50501, and the excitation liquid filling and waste liquid discharging needle group motion motor 50501 is connected with an excitation liquid filling and waste liquid discharging needle group-eccentric shaft 50502; the excitation liquid filling and waste liquid discharging needle set-eccentric shaft 50502 moves in the excitation liquid filling and waste liquid discharging needle set-limit groove 50503, and simultaneously drives the excitation liquid filling and waste liquid discharging needle set-connecting block I50504 to move up and down, and the excitation liquid filling and waste liquid discharging needle set-connecting block II 50505 is connected with the excitation liquid filling and waste liquid discharging needle set-connecting block I50504; two excitation liquid needle mounting positions 50506 and a liquid discharge needle mounting position 50507 are arranged on the excitation liquid filling and waste liquid discharge needle set-connecting block II 50505, two guide positioning rod mounting positions 50508 are also arranged, and a guide positioning rod 50509 is arranged on the guide positioning rod mounting position 50508, as shown in fig. 29-31.

An excitation liquid filling and waste liquid discharging needle set-limit structure 505010 is arranged above the excitation liquid filling and waste liquid discharging needle set-connecting block I50504, as shown in fig. 31.

The detection chamber 501 has a detection chamber shutter 50101 whose telescopic movement is controlled by a detection chamber shutter motor 50102, the detection chamber shutter 50101 has a cuvette moving port 50103, and a detection cuvette holder 501014 is located below the detection chamber shutter 50101.

As shown in fig. 32, the detection chamber 501 is further provided with a reaction cup top bar 50104, and when the reaction cup enters from the reaction cup moving port 50103, the reaction cup top bar 50104 is caught in the reaction cup position of the position detection reaction cup seat 501014; the reaction cup ejector pin 50104 is controlled by a reaction cup ejector pin movement motor 50108 to move up and down, the reaction cup ejector pin movement motor 50108 is connected with a reaction cup ejector pin-eccentric shaft 50109, the reaction cup ejector pin-eccentric shaft 50109 is positioned in a reaction cup ejector pin-limiting groove 501011 of the ejector pin slide connecting block 501010, and the ejector pin slide connecting block 501010 is fixedly connected with an ejector pin slide 501012; accordingly, one end of the lift pin slide 501012 is located within the lift pin stop 501013.

The detection reaction cup 501014 rotates under the control of the detection reaction cup rotating motor 50105; the detection reaction cup rotating driving wheel 50106 is driven to rotate by a detection reaction cup rotating motor 50105, and the detection reaction cup rotating driving wheel 50106 drives a detection reaction cup rotating driven wheel 50107 positioned at the bottom of the detection reaction cup 501014 to move through a belt, so as to drive the detection reaction cup 501014 to rotate, as shown in fig. 30.

In the specific operation, the detection chamber baffle motor 50102 controls the telescopic motion of the detection chamber baffle 50101, when the reaction cup is clamped to the detection chamber 501, the detection chamber baffle 50101 extends out, the reaction cup moves from the reaction cup moving port 50103 on the detection chamber baffle 50101 to enter the detection reaction cup seat 501014 of the detection chamber 501, and the reaction cup is received in the reaction cup position of the detection reaction cup seat 501014 by the reaction cup ejector rod 50104; the detection reaction cup seat 501014 rotates under the control of the detection reaction cup seat rotating motor 50105, reaction cups are sequentially added into the detection reaction cup seat 501014, then the detection reaction cup seat 501014 rotates, the exciting liquid filling and waste liquid discharging needle group moving motor 50501 is started, the exciting liquid filling and waste liquid discharging needle group 504 moves up and down, the exciting liquid is added into the reaction cups, waste liquid is sucked out through a liquid discharging needle after reaction, and the PMT 502 and the photon counter 503 sequentially perform optical detection on the reaction cups to obtain a detection result.

The foregoing illustrates and describes the principles, general features, and advantages of the present invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are given by way of illustration of the principles of the present invention, and that various changes and modifications, such as changes in the position of various elements mounted on a base, may be made without departing from the spirit and scope of the invention, and these changes and modifications are within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims

1. A full-automatic chemiluminescence immunoassay analyzer comprises a reaction cup loading module, a sample loading module, a kit loading module, a detection module and a magnetic separation cleaning module which are integrated and arranged on a base and are mutually independent; it is characterized in that the preparation method is characterized in that,

the kit loading module is used for storing reaction reagents;

2. The full-automatic chemiluminescence immunoassay analyzer of claim 1, further comprising a manipulator sample introduction module, an incubation module and a manipulator transfer module;

3. The full-automatic chemiluminescence immunoassay analyzer of claim 2, wherein the reaction cup loading module is provided with a reaction cup bin for accommodating reaction cups, a reaction cup slide control assembly is arranged below the reaction cup bin, and the reaction cup slide control assembly controls the reaction cups in the reaction cup bin to slide into the reaction cup seats.

4. The full-automatic chemiluminescence immunoassay analyzer according to claim 3, wherein the reaction cup chamber is provided with a plurality of mutually independent reaction cup storage chambers, and the outlet of the reaction cup storage chamber faces the reaction cup sliding surface; the reaction cup sliding from the sliding surface of the reaction cup enters a sliding position of the reaction cup, and the reaction cup is blocked by two reaction cup baffle plates in the reaction cup bin; the reaction cup sliding control assembly controls the reaction cup baffle two assemblies to move, so that the reaction cup positioned at the reaction cup sliding position slides into the reaction cup seat.

5. The full-automatic chemiluminescence immunoassay analyzer of claim 4, wherein the first reaction cup baffle assembly of the reaction cup slide control assembly cooperates with the second reaction cup baffle assembly to control the reaction cup to slide into the reaction cup seat.

6. The full-automatic chemiluminescence immunoassay analyzer of claim 5, wherein the second reaction cup baffle component is composed of a spring and a second reaction cup baffle; the reaction cup sliding control component comprises a reaction cup sliding support plate, the reaction cup sliding support plate is fixedly connected with a reaction cup baffle I in the reaction cup baffle I component, and a reaction cup sliding push block is further arranged on the reaction cup sliding support plate; the reaction cup sliding support plate can drive the first reaction cup baffle and the first reaction cup sliding push block to move along the telescopic direction of the spring.

7. The fully automated chemiluminescent immunoassay analyzer of claim 6 wherein the reaction cartridge has a reaction cartridge holder with a reaction cartridge holder through hole, the reaction cartridge baffle blocking the reaction cartridge through the reaction cartridge holder through hole.

8. The full-automatic chemiluminescence immunoassay analyzer of claim 7, wherein a reaction cup slide bottom plate is further arranged outside the reaction cup slide control assembly, and the reaction cup seat is arranged at the front end of the reaction cup slide bottom plate; a reaction cup sliding motor is arranged on the reaction cup sliding bottom plate and drives an eccentric shaft connected with a motor shaft connecting block to rotate; and an eccentric shaft limiting groove is formed in the bottom surface of the reaction cup sliding support plate, and the eccentric shaft moves in the eccentric shaft limiting groove and drives the reaction cup sliding support plate to move.

9. The fully automated chemiluminescent immunoassay analyzer of claim 8 wherein the first cuvette baffle is fixedly attached to the cuvette slide support plate by a cuvette baffle support plate in the first cuvette baffle assembly; and a limiting structure is arranged behind the reaction cup sliding support plate and is matched with a limiting optocoupler at the bottom of the reaction cup bin support for limiting.

10. The full-automatic chemiluminescent immunoassay analyzer of claim 9, wherein the cuvette loader module further comprises a cuvette carrier having a movable cuvette carrier having a cuvette pusher disposed thereon; the reaction cup seat pushing handle can push the reaction cup seat to rotate around the rotating shaft, so that the reaction cup in the reaction cup seat is changed from a lying position to a standing position, and the reaction cup slides into the reaction cup carrying seat from the inside of the reaction cup seat; the reaction cup carrying seat carries the reaction cup to a preset position, after a sample and a reaction reagent are added, the manipulator transferring module clamps the reaction cup added with the sample and the reaction reagent into the incubation module, and the reaction cup is incubated.

11. The full-automatic chemiluminescence immunoassay analyzer of claim 10, wherein the cuvette carrier device is further provided with a cuvette carrier motor, the cuvette carrier motor drives a cuvette carrier screw to rotate, and a cuvette carrier screw nut on the cuvette carrier screw is connected with the cuvette carrier seat; the reaction cup carrying screw rod nut is further connected with a reaction cup carrying sliding block, and the reaction cup carrying sliding block drives the reaction cup carrying seat to move along the reaction cup carrying sliding rail.

12. The fully automated chemiluminescent immunoassay analyzer of claim 1, wherein the sample cartridge loading module has a sample cartridge bay, a plurality of limit rails disposed within the sample cartridge bay, the limit rails cooperating with limit grooves on the bottom surface of the sample cartridge for limiting; and the top end of the sample box is provided with a sample box positioning structure which is matched with a limiting ball plunger of the sample box bin for limiting.

13. The full-automatic chemiluminescence immunoassay analyzer of claim 12, wherein a reaction cup waste groove is arranged below the sample box bin and is used for collecting waste after the reaction cup detection is finished; and a sample box handle is further arranged at one end of the sample box, which is far away from the sample box positioning structure.

14. The full-automatic chemiluminescence immunoassay analyzer according to claim 2, wherein the chip loading module comprises a chip bin, a plurality of chips are stacked in the chip bin; the chip carrying device also comprises a chip carrying groove, and the front end of the chip carrying groove in the moving direction is positioned below the chip bin; the chip carrying groove carries the chip to a chip pressure device, a sample feeding cavity of the chip is pressurized, and whole blood sample filtration is carried out; the sample sampling needle device sucks up the plasma/serum sample flowing into the chip sampling pool.

15. The full-automatic chemiluminescence immunoassay analyzer of claim 14, wherein a sampling top plate is further provided adjacent to the chip pressure device, the sampling top plate having a sampling port; the sample sampling needle device draws a plasma/serum sample through the sampling port.

16. The full-automatic chemiluminescence immunoassay analyzer of claim 15, wherein the chip pressure device is controlled by the chip pressure device movement motor to move up and down; the chip pressure device is provided with an air pressure interface, and the chip pressurizes the sample injection cavity through the external connection of the air pressure interface.

17. The full-automatic chemiluminescence immunoassay analyzer of claim 16, wherein a first chip carrier slot fixing plate and a second chip carrier slot fixing plate are respectively arranged at the front end and the rear end of the chip carrier slot; and a chip carrying groove support plate is arranged below the chip carrying groove and used for supporting the chip.

18. The full-automatic chemiluminescence immunoassay analyzer of claim 17, wherein the chip carrying groove is moved by a chip moving motor and the chip is transported to a sampling position; the chip moving motor drives the chip moving driving wheel to rotate, the chip moving belt I drives the chip moving driven wheel I to move, so that the chip moving driven wheel II is driven to move, the chip moving belt II drives the chip moving driven wheel III to move, the chip moving belt II bypasses the chip carrying groove support plate and the chip moving driven wheel IV, is fixedly connected with the chip carrying groove and then is connected with the chip moving driven wheel V, and belt transmission is realized; and the second chip moving belt is fixedly connected with the chip carrying groove through the first chip carrying groove fixing plate and the second chip carrying groove fixing plate.

19. The full-automatic chemiluminescent immunoassay analyzer of claim 18, wherein a chip discarding path is provided at a front end position of the chip carrier strip in the moving direction of the chip carrier strip, and a chip discarding slot is provided below the chip discarding path.

20. The full-automatic chemiluminescence immunoassay analyzer of claim 19, wherein the chip pressure device movement motor and the chip movement motor are stacked up and down and are both fixed on the chip loading module motor support; the chip pressure device is arranged between the chip bin and the chip loading module motor bracket; the chip waste groove is positioned on the side surfaces of the chip bin, the chip loading module motor support and the chip pressure device.

21. The full-automatic chemiluminescent immunoassay analyzer of claim 20, wherein the chip pressure device is disposed on a chip pressure device-slider connection block on which a chip pressure device-limiting structure is disposed; and a chip pressure device-sliding rail is arranged on the chip loading module motor support, and the chip pressure device-sliding block connecting block is fixedly connected with the chip pressure device-sliding block to drive the chip pressure device to move up and down along the chip pressure device-sliding rail.

22. The full-automatic chemiluminescence immunoassay analyzer of claim 21, wherein the inner side of the chip pressure device-slide block connection block is provided with a chip pressure device-limit groove; the chip pressure device moving motor is connected with a chip pressure device-eccentric shaft, the chip pressure device-eccentric shaft moves in the chip pressure device-limiting groove and simultaneously drives a chip pressure device-slide block connecting block to move up and down along the chip pressure device-slide rail, so that the chip pressure device is driven to move, and air pressurization is carried out on the chip.

23. The full-automatic chemiluminescence immunoassay analyzer of claim 14, wherein the chip carrier slot is hollowed out below and has a circular arc angle at the inner periphery.

24. The fully automated chemiluminescent immunoassay analyzer of claim 2 wherein the cartridge loading module has a reagent cartridge bay within which a number of cartridges are placed, each cartridge having a magnetic bead reagent cup therein; the magnetic bead reagent cup is kept in a uniformly-mixed state of the magnetic bead reagent in the magnetic bead reagent cup by the reagent uniformly-mixing component.

25. The full-automatic chemiluminescence immunoassay analyzer of claim 24, wherein a plurality of reagent kit limiting partitions II are arranged in the reagent kit bin, and a reagent kit placing space is arranged between every two adjacent reagent kit limiting partitions II.

26. The full-automatic chemiluminescence immunoassay analyzer of claim 25, wherein a partition limiting groove is arranged on the reagent kit limiting partition II, and a partition limiting lug is arranged on the reagent kit to be assembled and limited with the partition limiting groove.

27. The full-automatic chemiluminescence immunoassay analyzer of claim 26, wherein a reagent kit limiting partition I is further arranged on the outer side of the reagent kit limiting partition II.

28. The full-automatic chemiluminescence immunoassay analyzer of claim 24, wherein a kit limiting clamp is further provided on the kit, the kit limiting clamp having a kit limiting notch; the reagent box limiting notch can be matched with a reagent box limiting convex column on the reagent box bin to limit the reagent box.

29. The full-automatic chemiluminescence immunoassay analyzer of claim 24, wherein a gear structure is arranged at the lower part of the magnetic bead reagent cup, the gear structure is engaged with a sawtooth structure on a mixing plate of the reagent mixing assembly, the sawtooth structure is close to one side of the reagent box bin, and the magnetic bead reagent cup is rotated through the reciprocating motion of the mixing plate, so that the reagents in the magnetic bead reagent cup are mixed uniformly.

30. The full-automatic chemiluminescence immunoassay analyzer of claim 29, wherein the mixing plate is provided with a mixing plate limiting post, the reagent box bin is provided with a mixing plate limiting block, and the mixing plate limiting post is positioned in a mixing plate limiting groove in the mixing plate limiting block; the blending plate limiting block is also provided with a blending plate card combination groove which is used for clamping the blending plate.

31. The full-automatic chemiluminescence immunoassay analyzer of claim 29, wherein the mixing plate is provided with a reagent mixing limiting groove; the reagent blending assembly further comprises a reagent blending motor and a blending motor shaft connecting block, wherein a blending eccentric shaft is fixedly connected to the blending motor shaft connecting block, moves in the reagent blending limiting groove and drives the blending plate to reciprocate.

32. The fully automated chemiluminescent immunoassay analyzer of claim 24, wherein the bottom of the reagent cartridge compartment is provided with a cooling plate and a cooling fan.

33. The full-automatic chemiluminescence immunoassay analyzer of claim 2, wherein the magnetic separation cleaning module comprises a cleaning needle motion assembly having a magnetic separation cleaning motor, a magnetic separation cleaning screw and a magnetic separation cleaning screw nut connection block; a cleaning liquid needle group mounting position is arranged on the magnetic separation cleaning screw rod nut connecting block; the magnetic separation cleaning motor drives the magnetic separation cleaning screw rod to rotate, so that the cleaning liquid needle group positioned at the mounting position of the cleaning liquid needle group can move up and down along the magnetic separation cleaning screw rod; the cleaning liquid needle group comprises a liquid inlet needle and a liquid discharge needle.

34. The full-automatic chemiluminescence immunoassay analyzer of claim 33, wherein both sides of the magnetic separation cleaning screw nut connecting block are provided with partitions, and the magnetic separation cleaning screw nut connecting block is in contact with the partitions on both sides thereof, so that the magnetic separation cleaning screw nut connecting block moves up and down along the partitions.

35. The full-automatic chemiluminescence immunoassay analyzer of claim 34, wherein the magnetic separation cleaning module further comprises a magnetic separation seat, and the magnetic separation seat is provided with a plurality of reaction cup placement positions; the magnetic separation seat is controlled by a rotary motor of the magnetic separation seat to rotate, so that reaction cups on the magnetic separation seat are sequentially subjected to magnetic separation cleaning.

36. The fully automated chemiluminescent immunoassay analyzer of claim 35 wherein the magnetic separation cartridge rotating motor is located at the bottom of the magnetic separation cartridge; the magnetic separation seat rotating motor and the magnetic separation seat are both arranged close to the magnetic separation cleaning installation plate and are positioned on the same side of the magnetic separation cleaning installation plate; the magnetic separation cleaning motor is installed on the other side of the magnetic separation cleaning installation plate, the partition is installed above the magnetic separation cleaning motor, and the magnetic separation cleaning screw rod nut connecting block and the magnetic separation cleaning screw rod are arranged in the adjacent two partitions.

37. The full-automatic chemiluminescence immunoassay analyzer of claim 35, wherein each magnetic separation seat rotating motor individually controls one magnetic separation seat to rotate; each magnetic separation cleaning motor independently controls one magnetic separation cleaning screw rod nut connecting block to move up and down; the magnetic separation cleaning screw nut connecting block is connected to the magnetic separation cleaning screw nut and moves up and down along the partition.

38. The fully automated chemiluminescent immunoassay analyzer of claim 2 wherein the detection module has a detection chamber, a PMT and a photon counter; and a detection reaction cup seat is arranged in the detection chamber, excitation liquid is added into a reaction cup of the detection reaction cup seat through an excitation liquid adding and waste liquid discharging needle set, waste liquid after reaction is sucked out through a liquid discharging needle in the excitation liquid adding and waste liquid discharging needle set, and the PMT and the photon counter perform optical detection on the reaction cup in sequence to obtain a detection result.

39. The full-automatic chemiluminescence immunoassay analyzer of claim 38, wherein the excitation liquid filling and waste liquid discharging needle set is controlled to move up and down by an excitation liquid filling and waste liquid discharging needle set movement assembly; the exciting liquid filling and waste liquid discharging needle set motion assembly is provided with an exciting liquid filling and waste liquid discharging needle set motion motor, and the exciting liquid filling and waste liquid discharging needle set motion motor is connected with an exciting liquid filling and waste liquid discharging needle set-eccentric shaft; the exciting liquid filling and waste liquid discharging needle set-eccentric shaft moves in the exciting liquid filling and waste liquid discharging needle set-limiting groove and simultaneously drives the exciting liquid filling and waste liquid discharging needle set-connecting block I to move up and down, and the exciting liquid filling and waste liquid discharging needle set-connecting block II is connected with the exciting liquid filling and waste liquid discharging needle set-connecting block I; two exciting liquid needle mounting positions and one liquid discharge needle mounting position are arranged on the exciting liquid filling and waste liquid discharge needle set-connecting block II, two guide positioning rod mounting positions are also arranged, and guide positioning rods are mounted on the guide positioning rod mounting positions.

40. The fully automated chemiluminescent immunoassay analyzer of claim 38 wherein the detection chamber has a detection chamber barrier whose telescopic movement is controlled by a detection chamber barrier motor, the detection chamber barrier having a cuvette removal opening, the detection cuvette holder being located below the detection chamber barrier.

41. The full-automatic chemiluminescence immunoassay analyzer of claim 40, wherein a reaction cup top rod is further disposed in the detection chamber, and when the reaction cup enters from the reaction cup moving inlet, the reaction cup is received by the reaction cup top rod into the reaction cup position of the detection reaction cup seat.

42. The full-automatic chemiluminescence immunoassay analyzer of claim 41, wherein the detection reaction cup holder is rotated under the control of a detection reaction cup holder rotating motor; the detection reaction cup seat rotating motor drives the detection reaction cup seat rotating driving wheel to rotate, the detection reaction cup seat rotating driving wheel is located through belt driving, the detection reaction cup seat at the bottom of the detection reaction cup seat rotates to move from a driving wheel, and then the detection reaction cup seat is driven to rotate.

43. The full-automatic chemiluminescence immunoassay analyzer of claim 41, wherein the reaction cup top rod is controlled by a reaction cup top rod movement motor to move up and down, the reaction cup top rod movement motor is connected with a reaction cup top rod-eccentric shaft, the reaction cup top rod-eccentric shaft is positioned in a reaction cup top rod-limiting groove of a top rod slide block, and the top rod slide block is fixedly connected with a top rod slide; correspondingly, one end of the carrier glass of the ejector rod is positioned in the ejector rod limiting structure.