CN216703068U - Combined and detachable platelet-rich plasma preparation device - Google Patents
Combined and detachable platelet-rich plasma preparation device Download PDFInfo
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- CN216703068U CN216703068U CN202122506245.XU CN202122506245U CN216703068U CN 216703068 U CN216703068 U CN 216703068U CN 202122506245 U CN202122506245 U CN 202122506245U CN 216703068 U CN216703068 U CN 216703068U
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Abstract
The utility model discloses a combined and detachable platelet-rich plasma preparation device, and relates to the technical field of medical equipment. Including the push-and-pull rod, first rubber buffer, piston liquid storage tube, piston centrifuging tube and second rubber buffer, the push-and-pull rod is inner to cooperate with first rubber buffer, and the push-and-pull rod assembly is in piston liquid storage tube, and piston liquid storage tube below is equipped with piston centrifuging tube, and piston centrifuging tube below opening part is disposable public luer end cap, and the intraductal second rubber buffer that is equipped with the unanimity of piston centrifuging tube internal diameter that matches of piston centrifuging tube, and the trompil in the middle of liquid transfer channel and the second rubber buffer of piston liquid storage tube bottom cup joints the cooperation mutually. The utility model has the advantages of rapid and convenient preparation of PRP, safety, stability, cost reduction, simple device and convenient and reliable use.
Description
Technical Field
The utility model relates to the technical field of medical equipment, in particular to a combined and detachable platelet-rich plasma preparation device.
Background
Platelet-rich plasma (PRP) is high-concentration Platelet-rich plasma obtained by subjecting fresh whole blood to two gradient centrifuges, and the blood plasma, platelets, leukocytes and erythrocytes have different sedimentation rates, so that after 2 centrifuges, the blood components are roughly divided into three layers, namely a plasma layer, a white membrane layer (Platelet-rich plasma and leukocyte layer) and an erythrocyte layer. By this principle, platelet rich plasma is separated. After the platelet-rich plasma is activated, a large amount of growth factors are released, and the platelet-rich plasma has the effect of rapidly promoting the healing of tissue injury. Since the application of platelet rich plasma in oral and maxillofacial surgery, the application of Platelet Rich Plasma (PRP) at present covers medical treatment and beauty treatment, oral and maxillofacial surgery, sports medicine, orthopedics, diabetes wound treatment, rehabilitation medical science and other medical science, diseases are related from bone joints to soft tissues, and the adaptation diseases are continuously expanded.
Currently, as the efficacy of PRP technology is determined, safe and reliable, more and more innovative products are being developed for the preparation of platelet rich plasma. However, the PRP preparation device widely used at present basically has the defects of complex structure, high price, complicated operation (collection, separation, extraction, injection and the like), long time consumption, low platelet concentration in the prepared platelet-rich plasma, unstable plasma quality, easy pollution and the like, so that the PRP preparation device is greatly limited in clinical application and popularization.
Disclosure of Invention
Aiming at the defects in the prior art, the utility model aims to provide a combined and detachable platelet-rich plasma preparation device, so that PRP can be prepared quickly, conveniently, safely and stably, the cost is reduced, and the device is simple and convenient and reliable to use.
In order to achieve the purpose, the utility model is realized by the following technical scheme: the utility model provides a combination and detachable rich platelet plasma preparation facilities, including the push-and-pull rod, first rubber buffer, piston stock solution pipe, piston centrifuging tube and second rubber buffer, the push-and-pull rod inner cooperatees with first rubber buffer, the push-and-pull rod assembly is in piston stock solution pipe, piston stock solution pipe below is equipped with piston centrifuging tube, piston centrifuging tube below opening part is disposable public luer end cap, in the piston centrifuging tube be equipped with the second rubber buffer that piston centrifuging tube internal diameter is unanimous, the trompil in the middle of liquid-transfering channel and the second rubber buffer of piston stock solution bottom cup joints the cooperation mutually.
Preferably, the piston type liquid storage pipe is of a cylindrical structure, a first rubber plug with the same inner diameter as the piston type liquid storage pipe is matched in the cylindrical structure, and a push-pull rod is assembled on an opening on the first rubber plug. The opening below the piston type liquid storage tube is a first female luer connector, and the first female luer connector is matched with the liquid transfer channel and communicated with the piston type centrifugal tube.
Preferably, the liquid transfer channel is fixed in the second rubber plug and is a rigid channel, the upper end of the liquid transfer channel is a first male luer connector, the liquid transfer channel can be matched with a first female luer connector of the piston type liquid storage tube, and the liquid transfer channel is used for transferring blood in the piston type centrifuge tube and the piston type liquid storage tube. The lower end is a rotary chuck of a pipetting channel.
Preferably, the piston type centrifuge tube is a cylindrical device with a diameter larger than that of the piston type liquid storage tube, an opening below the piston type centrifuge tube is a second female luer connector, and the second female luer connector is matched with the disposable male luer plug.
Preferably, the push-pull rod comprises a cross-shaped core rod, a round sheet is assembled at the upper end of the cross-shaped core rod and serves as a push-pull plate, and a push-pull rod chuck matched with the first rubber plug is arranged at the lower end of the cross-shaped core rod.
Preferably, the opening of the piston type liquid storage pipe is fixed in the second rubber plug through the chuck, penetrates through the second rubber plug to the piston type centrifugal pipe, and is level with the lower end of the second rubber plug.
Preferably, the diameter of the piston type liquid storage tube is smaller than that of the piston type centrifugal tube, so that the piston type centrifugal tube can be used as a push-pull rod of the piston type centrifugal tube for suction and injection while keeping the sealing.
Preferably, the lower end of the piston type centrifuge tube is provided with a second female luer connector which can be connected with a disposable male luer plug and can be connected with a three-way tube and a sterile injection needle for injection treatment and preparation of platelet-rich plasma gel.
Preferably, the pipe walls of the piston type liquid storage pipe and the piston type centrifugal pipe are provided with scale marks for marking milliliter numbers, and the piston type liquid storage pipe and the piston type centrifugal pipe can be used for determining the volume of blood for liquid drawing and transferring.
The connecting mode of the opening channel of the piston type liquid storage pipe and the interface of the second rubber plug adopts luer connection, the opening is a female luer connector, and the interface of the second rubber plug is a male luer connector. The connection and disconnection can be performed by rotation.
After the qualified platelet-rich plasma is prepared, the piston type liquid storage tube is separated from the piston type centrifugal tube after anticlockwise rotation, and can be independently used as an injector for platelet-rich plasma injection treatment.
The utility model has the beneficial effects that: by adopting the module combined design, all preparation chambers can be disassembled through luer interfaces, thereby facilitating the sterile storage of equipment and the puncture injection treatment of different parts. In the preparation process, the device is not required to be disassembled and assembled, all processes for preparing the platelet-rich plasma are in a completely sealed state, and the complete sterility can be ensured by the centrifugation and the transfer of the blood. All preparation processes are in the same device, so that the free-hand operation of blood separation and the blood transfer process are reduced, and the stability and the safety of the prepared product are ensured. The preparation method can simplify the preparation process, has low cost, and can provide a device and a method for high-concentration and low-cost platelet-rich plasma for clinical research and treatment of musculoskeletal diseases.
Drawings
The utility model is described in detail below with reference to the drawings and the detailed description;
FIG. 1 is a schematic view of the present invention in a package storage state and an assembled state in a centrifuge;
FIG. 2 is a schematic structural view showing a state where the push-pull rod is coupled to the first rubber stopper in the present invention;
FIG. 3 is a schematic structural view of the push-pull rod and the first rubber stopper in a top view;
FIG. 4 is a schematic structural diagram of the state that the female luer connector at the outlet of the piston type liquid storage tube is connected with the liquid transfer channel and the liquid transfer channel is combined with the second rubber stopper of the piston type centrifuge tube in the utility model;
FIG. 5 is a schematic structural view showing a state in which a female luer connector at the outlet of a piston-type liquid storage tube is connected with a liquid transfer channel, and the liquid transfer channel is combined with a second rubber stopper of the piston-type centrifuge tube in a top view;
FIG. 6 is a schematic structural view of a female luer connector at an outlet at the lower end of a piston type liquid storage tube and a piston type centrifuge tube in the utility model;
FIG. 7 is a schematic structural view of a disposable male luer plug connected to a female luer connector of a piston centrifuge tube according to the present invention;
FIG. 8 is a schematic view of a tee of the present invention for connection with a female luer fitting on the outlet of a piston centrifuge tube;
FIG. 9 is a schematic diagram of the scale marks on the walls of the piston-type liquid storage tube and the piston-type centrifuge tube according to the present invention.
Detailed Description
In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the utility model easy to understand, the utility model is further described with the specific embodiments.
Referring to fig. 1 to 9, the following technical solutions are adopted in the present embodiment: the utility model provides a combination and detachable rich platelet plasma preparation facilities, including push-and-pull rod 1, first rubber buffer 2, piston stock solution pipe 3, piston centrifuging tube 4 and second rubber buffer 6, 1 the inner and first rubber buffer 2 of push-and-pull rod cooperate, push-and-pull rod 1 assembles in piston stock solution pipe 3, 3 below of piston stock solution pipe are equipped with piston centrifuging tube 4, 4 below openings of piston centrifuging tube are disposable public luer end cap 8, match in the piston centrifuging tube 4 with the second rubber buffer 6 that 4 internal diameters of piston centrifuging tube are unanimous, the trompil that moves liquid passageway 5 and the second rubber buffer 6 of 3 bottoms of piston stock solution pipe cup joints the cooperation mutually.
It is worth noting that piston type liquid storage tube 3 be the cylindric structure, match in the cylindric structure and be equipped with first rubber buffer 2 unanimous with 3 internal diameters of piston type liquid storage tube, be equipped with push-and-pull rod 1 on the trompil on first rubber buffer 2. The opening below the piston type liquid storage tube 3 is a first female luer connector 31, and the first female luer connector 31 is matched with the liquid transfer channel 5 and communicated with the piston type centrifuge tube 4.
It should be noted that the liquid transfer channel 5 is fixed in the second rubber stopper, is a rigid channel, has a first male luer 51 at the upper end, can be matched with the first female luer 31 of the piston-type liquid storage tube, and is a channel for transferring blood in the piston-type centrifuge tube and the piston-type liquid storage tube. The lower end is a pipetting channel rotary chuck 52.
It is worth noting that the piston type centrifuge tube 4 is a cylindrical device with a diameter larger than that of the piston type liquid storage tube 3, a second female luer connector 7 is arranged at an opening below the piston type centrifuge tube 4, and the second female luer connector 7 is matched with a disposable male luer plug 8.
It is worth noting that the push-pull rod 1 comprises a cross-shaped core rod 11, a round thin sheet is assembled at the upper end of the cross-shaped core rod 11 to serve as a push-pull plate 12, and a push-pull rod chuck 13 matched with the first rubber plug 2 is arranged at the lower end of the cross-shaped core rod 11.
It is worth noting that the opening of the piston type liquid storage tube 3 is fixed in the second rubber plug 6 through the chuck 13, passes through the second rubber plug 6 to the piston type centrifuge tube 4, and is flush with the lower end of the second rubber plug.
It should be noted that the diameter of the piston-type liquid storage tube 3 is shorter than that of the piston-type centrifuge tube 4, so that the piston-type centrifuge tube 3 can be used as a push-pull rod of the piston-type centrifuge tube 4 for suction and injection while maintaining the sealing of the piston-type centrifuge tube.
It is worth noting that the lower end of the piston type centrifuge tube 4 is provided with a second female luer connector 7 which can be connected with a disposable male luer plug 8 and can be connected with a three-way tube 9 and a sterile injection needle for injection treatment and preparation of platelet-rich plasma gel; the center of the three-way pipe 9 is provided with a rotary valve 91, and three channels of the three-way pipe 9 are connected with a second male luer 92, a third male luer 93 and a third female luer 94.
In addition, piston liquid storage tube and piston centrifuging tube pipe wall all be provided with the scale mark of mark milliliter number, can be used to make clear and definite the blood volume of drawing liquid and shifting.
The specific embodiment adopts a secondary gradient centrifugation method to prepare the high-concentration platelet-rich plasma, and the actual operation mainly comprises the following steps.
1. And connecting the piston type centrifuge tube with a second rubber plug of the piston type liquid storage tube, separating the piston type centrifuge tube from a three-way tube at the lower end of the piston type centrifuge tube, connecting a sterile injection needle, and extracting 2ml of sodium citrate anticoagulant. And (3) taking down the sterile injection needle, connecting a female luer connector of the piston type centrifuge tube with the blood taking needle, taking down the elbow joint area for venous blood drawing under sterile operation, taking the piston type liquid storage tube as a push-pull rod at the moment, and pulling the piston type liquid storage tube backwards. Drawing the proper venous blood into the piston type centrifugal tube.
2. The disposable male plug is connected with the outlet of the piston type centrifugal tube for pumping blood, so that the piston type centrifugal tube is completely sealed, and the sodium citrate anticoagulant is completely mixed with venous blood by slowly shaking. The device is placed into a centrifuge, and is centrifuged for 10 minutes for the first time by a centrifugal force of 900g, red blood cells are deposited into the bottommost part of a piston type centrifuge tube and only contain a small amount of platelets due to different sedimentation rates of blood cell components, the middle part mainly contains high-concentration platelets and white blood cells, and the upper layer is plasma and contains a small amount of platelets.
3. After the first centrifugation, the preparation device is carefully taken out, placed on a syringe bracket, a push-pull rod of the piston type liquid storage tube is pulled, and the upper layer, the middle layer and the part 1-2mm below the liquid level of the erythrocyte layer in the piston type centrifugal tube are extracted. And (4) completely introducing the part of liquid into the piston type liquid storage tube (introducing the extracted upper layer, middle layer and small part of red blood cell layer into the piston type liquid storage tube for temporary storage). And (5) temporarily storing.
4. After the piston type liquid storage tube is pumped to obtain the upper layer liquid and the middle layer liquid, the disposable centrifuge tube plug is opened, and the piston type liquid storage tube is used as a push-pull rod of the piston type centrifuge tube to push, so that the red blood cells in the piston type centrifuge tube are discharged and discarded. And connecting the outlet of the piston type centrifugal tube by taking the disposable male luer plug again to completely seal the piston type centrifugal tube.
5. And pushing the liquid stored in the piston type liquid storage pipe into the piston type centrifugal pipe, and putting the preparation device into the centrifugal machine after the liquid is completely sent into the piston type centrifugal pipe. A second centrifugation was performed with a centrifugal force of 1100g for 10 min.
6. After the second centrifugation, the blood is roughly divided into three layers, namely, upper plasma, intermediate platelets, and lower red blood cells. The preparation device was carefully removed and placed on a syringe holder. And (3) taking the piston type liquid storage tube as a push-pull rod of the piston type centrifugal tube, pulling the piston type liquid storage tube, extracting the upper 3/4 liquid, and taking the residual 1/4 lower layer liquid as the prepared platelet-rich plasma.
7. The disposable aseptic plug is detached, the universal aseptic syringe needle is connected, and the piston type liquid storage tube is used as a push-pull rod of the piston type centrifuge tube again, so that the tissue or joint aseptic puncture injection treatment can be carried out. If the injection treatment part is a local fine part, the push-pull rod of the piston type liquid storage tube can be pulled, platelet-rich plasma in the piston type centrifugal tube is sucked into the piston type liquid storage tube, the piston type liquid storage tube is separated from the piston type centrifugal tube, and the first female luer connector of the piston type liquid storage tube is connected with the universal sterile injection needle head, so that the injection treatment of the local fine part can be carried out.
This embodiment's piston liquid storage tube and piston centrifuging tube are long tube-shaped lumen, the lower extreme is a coniform end, can make the platelet gather at the centrifuging tube lower extreme as far as possible, 6 bottoms of first rubber buffer 2 and second rubber buffer are with piston liquid storage tube 3, the conical design of the 4 conical bottoms of piston centrifuging tube complete matching, make platelet rich plasma gather better after the centrifugation, reach complete transfer to piston liquid storage tube in-process with liquid suction, in with platelet rich plasma injection process, make the platelet after the enrichment inject to the target site completely.
This embodiment connects 5 upper ends of liquid-transfering channel of piston liquid storage pipe 3 and piston centrifuging tube 4 and is first public luer 51, can be connected with the first female luer 31 of piston liquid storage pipe lower extreme open-ended, and the middle section of pipette is a long and thin tubulose passageway, and the lower extreme is the rotatory dop 52 of liquid-transfering channel, can match with the trompil of second rubber buffer 6, and long tubulose passageway lets in second rubber buffer 6 bottom. By pulling the push-pull rod of the piston type liquid storage tube, the upper layer plasma in the piston type centrifugal tube can be sucked into the piston type liquid storage tube through the liquid transfer channel for temporary storage.
The lower end opening of the piston type liquid storage tube 3 of the embodiment is a first female luer connector 31 matched with a disposable sterile male luer plug, and after liquid pumping is finished, the disposable plug is connected with a piston type centrifugal tube, so that the piston type centrifugal tube can be completely sealed and placed into a platelet-rich plasma centrifuge for centrifugation. The female luer connector at the outlet of the piston type centrifuge tube can be connected with various types of common sterile injection needles for platelet-rich plasma injection treatment.
The tube walls of the piston type liquid storage tube and the piston type centrifugal tube of the embodiment are printed with milliliter standard scales, so that blood can be accurately extracted, and whether a proper amount of qualified platelet-rich plasma is prepared or not can be measured.
The specific embodiment is also provided with a common medical disposable three-way pipe, the upper section of the three-way pipe can be connected with a piston type centrifuge tube or a piston type liquid storage tube, the side surface channel is connected with another syringe for extracting thrombin, and the syringes at the two sides are slowly pushed, so that the platelet rich plasma in a gel state can be obtained in the third channel of the three-way pipe.
The rubber plug of the embodiment adopts a common medical rubber plug, the material adopts butyl rubber, the rubber plug has excellent air tightness and elasticity, and the piston type liquid storage tube, the piston type centrifuge tube, the liquid transfer channel, the core rod, the three-way tube and the disposable plug are all made of high polymer polypropylene materials.
The foregoing shows and describes the general principles and broad features of the present invention and advantages thereof. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the utility model as claimed. The scope of the utility model is defined by the appended claims and equivalents thereof.
Claims (9)
1. The utility model provides a combination and detachable rich platelet plasma preparation facilities, a serial communication port, including push-and-pull rod (1), first rubber buffer (2), piston liquid reserve pipe (3), piston centrifuging tube (4) and second rubber buffer (6), push-and-pull rod (1) inner cooperatees with first rubber buffer (2), push-and-pull rod (1) assembly is in piston liquid reserve pipe (3), piston liquid reserve pipe (3) below is equipped with piston centrifuging tube (4), piston centrifuging tube (4) below opening part is disposable public luer end cap (8), be matched with in piston centrifuging tube (4) with second rubber buffer (6) that piston centrifuging tube (4) internal diameter is unanimous, liquid-moving channel (5) and the trompil in the middle of second rubber buffer (6) of piston liquid reserve pipe (3) bottom cup joint the cooperation mutually.
2. The combined and detachable platelet-rich plasma preparation device according to claim 1, wherein the piston-type liquid storage tube (3) is a cylindrical structure, a first rubber plug (2) with the same inner diameter as the piston-type liquid storage tube (3) is matched in the cylindrical structure, a push-pull rod (1) is arranged on an opening on the first rubber plug (2), a first female luer connector (31) is arranged on an opening below the piston-type liquid storage tube (3), and the first female luer connector (31) is matched with the liquid transfer channel (5) and communicated with the piston-type centrifuge tube (4).
3. The combined and detachable platelet rich plasma preparation device according to claim 1, wherein the pipetting channel (5) is fixed in the second rubber plug and is a rigid channel, the upper end of the pipetting channel is a first male luer (51), the first male luer (51) is matched with a first female luer (31) of the piston type liquid storage tube, and the lower end of the pipetting channel is a rotary chuck (52).
4. The combined and detachable platelet-rich plasma preparation device according to claim 1, wherein the piston-type centrifuge tube (4) is a cylindrical device with a diameter larger than that of the piston-type liquid storage tube (3), the lower opening of the piston-type centrifuge tube (4) is provided with a second female luer connector (7), and the second female luer connector (7) is matched with the disposable male luer plug (8).
5. A combined and detachable platelet-rich plasma preparation device according to claim 1 wherein the push-pull rod (1) comprises a cross-shaped core rod (11), the upper end of the cross-shaped core rod (11) is equipped with a circular thin plate as a push-pull plate (12), and the lower end of the cross-shaped core rod (11) is provided with a push-pull rod chuck (13) matching with the first rubber stopper (2).
6. The combined and detachable platelet-rich plasma preparation device according to claim 1, wherein the opening of the piston-type liquid storage tube (3) is fixed in the second rubber plug (6) through the spin chuck (13), passes through the second rubber plug (6) to the piston-type centrifuge tube (4), and is flush with the lower end of the second rubber plug.
7. The combined and detachable platelet-rich plasma preparation device according to claim 1, wherein the piston-type liquid storage tube (3) has a shorter diameter than the piston-type centrifuge tube (4).
8. The combined and detachable platelet rich plasma preparation device according to claim 1, wherein the lower end of the piston type centrifuge tube (4) is a second female luer connector (7), and the second female luer connector (7) is connected with a disposable male luer plug (8), a three-way tube (9) or a sterile injection needle.
9. The combined and detachable platelet-rich plasma preparation device according to claim 1, wherein the tube walls of the piston-type liquid storage tube and the piston-type centrifuge tube are provided with scale marks for marking milliliters.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202122506245.XU CN216703068U (en) | 2021-10-19 | 2021-10-19 | Combined and detachable platelet-rich plasma preparation device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202122506245.XU CN216703068U (en) | 2021-10-19 | 2021-10-19 | Combined and detachable platelet-rich plasma preparation device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN216703068U true CN216703068U (en) | 2022-06-10 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202122506245.XU Active CN216703068U (en) | 2021-10-19 | 2021-10-19 | Combined and detachable platelet-rich plasma preparation device |
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| CN (1) | CN216703068U (en) |
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2021
- 2021-10-19 CN CN202122506245.XU patent/CN216703068U/en active Active
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