CN214041434U - Micro-fluidic detection system for refrigerator and refrigerator - Google Patents

Abstract

The utility model relates to a micro-fluidic detecting system and refrigerator for refrigerator, micro-fluidic detecting system includes: the sample table is used for placing a sample cup, and the sample cup is used for containing sample liquid; the microfluidic biochip is provided with a sample inlet, a communication port and a detection pool formed inside the microfluidic biochip, wherein the sample inlet, the detection pool and the communication port are sequentially communicated through a microchannel, so that a sample liquid in contact with the sample inlet is allowed to flow into the microchannel and flow into the detection pool through the microchannel; and the detection mechanism is used for detecting the detection pool after the sample liquid in the detection pool reacts with the detection reagent in the detection pool so as to obtain the preset detection parameters of the sample liquid. The sample stage is configured to move controllably or operably to transport a sample cup placed thereon through the sample stage to a position that allows a sample fluid in the sample cup to contact a sample inlet of the microfluidic biochip, thereby facilitating a sample application or sampling operation by a user.

Description

Micro-fluidic detection system for refrigerator and refrigerator

Technical Field

The utility model relates to a cold-stored freezing technique especially relates to a micro-fluidic detecting system and refrigerator for refrigerator.

Background

With the improvement of living standard of people, pesticide residues, viruses, nutrient elements or other aspects of edible food materials are generally required to be detected in daily life so as to qualitatively or quantitatively acquire the conditions of the food materials. For example, due to the abuse problem of pesticides, fruits, vegetables and agricultural and sideline products purchased daily by people may have the problem of excessive pesticide residue content, and if the problem of excessive pesticide residue content of the foods cannot be found in time, the foods can cause great harm after being taken by human bodies. As another example, breast feeding advocated at present is the best for infants only when breast milk has normal nutritional value, but in cases of lactating mothers suffering from illness, taking medicine, surgery or other conditions, the nutritional content of milk secreted by the mothers may be reduced and viruses may be produced, thereby affecting the growth and health of the infants.

Among the detection methods, the method for detecting by utilizing the microfluidic biochip is relatively quick, small in size and suitable for being used at home. However, the sample application of the existing microfluidic biochip requires manual operation by a user, and is very troublesome to use; or the sample liquid needs to be conveyed to the microfluidic biochip by means of a complicated sample liquid conveying device, so that the structure is very complicated, the cost is high, the occupied volume is large, and the device is not suitable for a refrigerator.

SUMMERY OF THE UTILITY MODEL

The utility model discloses an object of first aspect aims at overcoming at least one defect of prior art, provides a convenient, simple structure's of application of sample micro-fluidic detecting system suitable for refrigerator.

It is a further object of the first aspect of the present invention to improve the degree of automation of a microfluidic detection system.

It is another further object of the first aspect of the present invention to improve the stability of the movement of the sample stage.

The utility model discloses the purpose of second aspect is to provide a refrigerator with above-mentioned micro-fluidic detecting system.

According to the utility model discloses an aspect, the utility model provides a micro-fluidic detecting system for refrigerator, it includes:

the sample table is used for placing a sample cup, and the sample cup is used for containing a sample liquid;

a microfluidic biochip having a sample inlet, a communication port, and a detection cell formed therein, the sample inlet, the detection cell, and the communication port being sequentially communicated through a microchannel, thereby allowing a sample liquid contacting the sample inlet to flow into the microchannel and flow into the detection cell through the microchannel;

the detection mechanism is used for detecting the detection cell to obtain preset detection parameters of the sample liquid; wherein

The sample stage is configured for controlled or operable movement to transport a sample cup placed thereon through the sample stage to a position that allows the sample fluid in the sample cup to contact a sample inlet of the microfluidic biochip.

Optionally, the microfluidic biochip is fixedly arranged above the sample stage, and the sample inlet is located at the bottom of the microfluidic biochip; and is

The microfluidic detection system also comprises a lifting mechanism for driving the sample stage to move up and down, so that the sample stage is switched between a detection position allowing sample liquid in a sample cup placed on the sample stage to be in contact with the sample inlet and an initial position which is a preset distance below the detection position.

Optionally, the lifting mechanism comprises:

a lift motor for outputting a driving force; and

the transmission screw rod is arranged in the vertical direction and is connected with an output shaft of the lifting motor so as to rotate under the driving of the lifting motor; wherein

The sample table penetrates through the transmission screw rod and moves up and down along the transmission screw rod along with the rotation of the transmission screw rod.

Optionally, the lifting mechanism further comprises:

the nut is arranged on the transmission screw rod in a penetrating mode, is in threaded connection with the transmission screw rod and moves up and down along the transmission screw rod along with the rotation of the transmission screw rod; wherein

The sample stage is fixedly connected with the nut so as to drive the sample stage to move up and down through the nut.

Optionally, the lifting mechanism further comprises:

the sliding rail is arranged beside the transmission screw rod in parallel with the transmission screw rod;

the sliding block is movably arranged on the sliding rail; wherein

The sample table is fixedly connected with the sliding block so as to guide the sample table to move up and down through the matching of the sliding rail and the sliding block.

Optionally, the lifting mechanism further comprises:

the limit switch is arranged close to the upper part of the transmission screw rod and used for prompting the lifting motor to stop running when the sample table moves upwards to touch the limit switch; and is

The position of the limit switch is set to enable the sample stage to be at the detection position when the lifting motor stops running under the trigger of the limit switch.

Optionally, the microfluidic detection system further comprises:

and the buffer driving device is used for driving a buffer into the sample cup arranged on the sample table, so that the buffer is mixed with the sample in the sample cup to generate the sample liquid.

Optionally, the sample stage comprises:

a support table for supporting the sample cup; and

the oscillator is arranged on the supporting platform and used for oscillating the sample cup after the sample cup is placed on the supporting platform, so that the buffer solution in the sample cup is fully mixed with the sample.

Optionally, the sample stage further comprises:

and the weighing sensor is arranged below the supporting table and used for measuring the weight of the sample, so that the buffer driving device is allowed to convey a preset amount of buffer matched with the weight of the sample to the sample cup.

According to the utility model discloses a second aspect, the utility model discloses still provide a refrigerator, it includes the micro-fluidic detection system that any above-mentioned embodiment relates.

The utility model discloses a micro-fluidic detecting system has the sample platform that is used for placing the sample cup, and the sample platform can controlled ground or operable motion to carry the sample cup of placing on it to the position that allows the sample liquid in the sample cup to contact with micro-fluidic biochip's introduction port through the sample platform, realized micro-fluidic biochip's application of sample promptly. The user only needs to place the sample cup on the sample platform, perhaps, place the sample cup with the sample platform remove the sample platform to the position that contacts with the introduction port of micro-fluidic biochip after the sample platform can, the application of sample operation is very convenient, labour saving and time saving. In addition, the sample platform is arranged to be movable, so that complex structures such as a sample liquid conveying pump, a conveying pipeline, a sampling needle and the like are omitted, the structure of the micro-fluidic detection system is very simple, and the micro-fluidic detection system is suitable for being integrated on a refrigerator and is convenient for family use.

Furthermore, the microfluidic biochip is arranged above the sample table, so that the sample inlet is positioned at the bottom of the sample table, and the microfluidic detection system is further provided with a lifting mechanism for driving the sample table to move up and down between the detection position and the initial position which is at the preset distance below the detection position. And the initial position is in the preset distance below the detection position, so that the sample cup cannot interfere with other structures such as a microfluidic biochip and the like when being placed, and the convenience and the comfort level of operation are further improved.

Furthermore, the lifting mechanism comprises a slide rail arranged in parallel with the transmission screw rod and a slide block movably arranged on the slide rail besides drive modules such as a drive motor and the transmission screw rod, the sample table is fixedly connected with the slide block, the slide block is driven to synchronously move when the sample table moves in the vertical direction under the action of the drive modules, the slide block is limited on the slide rail, and the slide rail has guiding and limiting functions on the movement of the slide block, so that the sample table is indirectly guided and limited, the sample table is prevented from being shifted or clamped in the moving process, and the moving stability of the sample table is improved.

The above and other objects, advantages and features of the present invention will become more apparent to those skilled in the art from the following detailed description of specific embodiments thereof, taken in conjunction with the accompanying drawings.

Drawings

Some specific embodiments of the present invention will be described in detail hereinafter, by way of illustration and not by way of limitation, with reference to the accompanying drawings. The same reference numbers in the drawings identify the same or similar elements or components. Those skilled in the art will appreciate that the drawings are not necessarily drawn to scale. In the drawings:

fig. 1 is a schematic block diagram of a microfluidic detection system for a refrigerator according to one embodiment of the present invention;

fig. 2 is a schematic exploded view of a microfluidic detection system for a refrigerator according to an embodiment of the present invention;

fig. 3 is a schematic structural view of the internal structure of a microfluidic detection system according to an embodiment of the present invention;

fig. 4 is a schematic exploded view of the internal structure of a microfluidic detection system according to an embodiment of the present invention;

fig. 5 is a schematic cross-sectional view of a microfluidic biochip according to one embodiment of the present invention;

fig. 6 is a schematic structural view of an elevating mechanism and a sample stage in an assembled state according to an embodiment of the present invention;

fig. 7 is a schematic structural view of a lifting mechanism and a sample stage in a disassembled state according to an embodiment of the present invention;

fig. 8 is a schematic structural view of a refrigerator according to an embodiment of the present invention;

fig. 9 is a schematic exploded view of a door body according to an embodiment of the present invention.

Detailed Description

The utility model provides a micro-fluidic detecting system for refrigerator at first, the utility model discloses a micro-fluidic detecting system is used for carrying out qualitative or quantitative determination to the detection parameters of predetermineeing of sample liquid, should predetermine the detection parameters for example can be for being used for expressing the incomplete parameter of farming that whether the incomplete volume of farming exceeds standard and/or the incomplete value of farming, be used for expressing the nutrient parameter whether up to standard and/or the concrete content of nutrient element, be used for expressing specific harmful substance (for example specific virus) whether exceed standard and/or the specific material parameter of concrete content etc..

Fig. 1 is a schematic structure diagram of a micro-fluidic detection system for a refrigerator according to an embodiment of the present invention, fig. 2 is a schematic structure exploded view of a micro-fluidic detection system for a refrigerator according to an embodiment of the present invention, fig. 3 is a schematic structure diagram of an internal structure of a micro-fluidic detection system according to an embodiment of the present invention, and fig. 4 is a schematic structure exploded view of an internal structure of a micro-fluidic detection system according to an embodiment of the present invention. For ease of understanding, a sample cup 2 is also shown in fig. 1-4.

Referring to fig. 1 to 4, the microfluidic detection system 1 of the present invention includes a microfluidic biochip 10, a detection mechanism 20, and a sample stage 70. It will be appreciated by those skilled in the art that the specific selection of the microfluidic biochip 10 and detection mechanism 20 used in the microfluidic detection system may vary when the predetermined detection parameters for detection are different. For example, when the microfluidic detection system is used for pesticide residue detection, the microfluidic biochip 10 can be a microfluidic pesticide residue detection chip capable of providing detection conditions for pesticide residue, and the detection mechanism 20 can be a pesticide residue detection mechanism capable of detecting pesticide residue parameters of pesticide residue.

Fig. 5 is a schematic cross-sectional view of a microfluidic biochip according to one embodiment of the present invention. The microfluidic biochip 10 has a sample inlet 111, a communication port 112, and a detection cell 121 formed therein, and the sample inlet 111, the detection cell 121, and the communication port 112 are sequentially communicated through a microchannel 14, thereby allowing a sample liquid in contact with the sample inlet 111 to flow into the microchannel 14 and flow into the detection cell 121 through the microchannel 14. The utility model relates to a microchannel means the tiny runner or the capillary flow channel of area of overflowing at the predetermined size within range to make it have the suitable ability of keeping its interior liquid. The sample inlet 111 and the communication port 112 may be formed at the end of the microfluidic biochip 10. Further, the sample inlet 111 and the communication port 112 are preferably formed at different ends of the microfluidic biochip 10.

The detection mechanism 20 is used for detecting the detection cell 121 to obtain preset detection parameters of the sample liquid. Specifically, the detection cell 121 may be provided with a detection reagent in advance, or the detection reagent may be manually or automatically added to the detection cell 121, so that the detection mechanism 20 detects the detection cell 121 after the sample solution in the detection cell 121 reacts with the detection reagent therein.

The sample stage 70 is used for placing the sample cup 2, and the sample cup 2 is used for containing a sample liquid. And, the sample stage 70 is arranged to be controllably or operatively moved to transport the sample cup 2 placed thereon by the sample stage 70 to a position allowing the sample liquid in the sample cup 2 to contact the sample inlet 111 of the microfluidic biochip 10. Thus, sample application of the microfluidic biochip 10 is achieved. The user only needs to place the sample cup 2 on the sample stage 70, or place the sample cup 2 on the sample stage 70 and then move the sample stage 70 to the position contacting with the sample inlet 111 of the microfluidic biochip 10, so that the sample adding operation is very convenient and fast, and time and labor are saved. In addition, the sample stage 70 is movably arranged, so that complex structures such as a sample liquid delivery pump, a delivery pipeline, a sampling needle and the like are omitted, the structure of the microfluidic detection system 1 is very simple, and the microfluidic detection system is suitable for being integrated on a refrigerator and is convenient for family use.

In a specific embodiment, when the detecting mechanism 20 is a pesticide residue detecting mechanism for detecting pesticide residue parameters of pesticide residue, an enzyme inhibition rate method can be used to perform rapid qualitative detection on whether pesticide residue in the sample liquid exceeds standard. At this time, the microfluidic biochip 10 further includes a reaction cell 122 formed therein, and the reaction cell 122 is located on a main channel formed by sequentially communicating the sample inlet 111, the detection cell 121, and the communication port 112, and is communicated between the sample inlet 111 and the detection cell 121, so that the sample solution firstly reacts with the reaction reagent in the reaction cell 122 and then flows into the detection cell 121. The reaction cell 122 is communicated with the sample inlet 111, and the reaction cell 122 is communicated with the detection cell 121 through the microchannel 14. The reaction reagent and the detection reagent for pesticide residue detection can be an enzyme reagent and a color-developing agent respectively. The reaction cell 122 is used for allowing the sample liquid to react with the enzyme reagent therein, and the sample liquid after reacting with the enzyme reagent flows into the detection cell 121 to react with the color developing agent in the detection cell 121. The detection mechanism 20 may be selected as a photoelectric detection mechanism, and may include a light source 21 and a photosensitive element 22 respectively disposed at two opposite sides of the microfluidic biochip 10 and facing the detection cell 121, light emitted from the light source 21 is irradiated to the detection cell 121, and light passing through the detection cell 121 is guided to the photosensitive element 22, so that it is beneficial to determine absorbance change in the detection cell 121 through a light intensity signal received by the photosensitive element 22, and further calculate the pesticide residue inhibition rate. Further, the detecting mechanism 20 further includes a heating plate 24 for supplying heat to the detecting cell 121 and a temperature controller 25 for controlling the heating plate 24 to have a constant heating power, so that the sample liquid and the detecting reagent in the detecting cell 121 can be reacted sufficiently and quickly.

In some embodiments, the microfluidic biochip 10 is fixedly disposed above the sample stage 70, and the sample inlet 111 is located at the bottom of the microfluidic biochip 10. It should be noted that the term "fixed" of the microfluidic biochip 10 as used herein means that the microfluidic biochip 10 is not movable after mounting, but not necessarily non-removable. That is, the microfluidic biochip 10 is not movable, and the sample stage 70 is movable.

Further, the microfluidic detection system 1 further includes a lifting mechanism 60 for driving the sample stage 70 to move up and down, so that the sample stage 70 is switched between a detection position allowing the sample liquid in the sample cup 2 placed on the sample stage 70 to contact the sample inlet 111 and an initial position at a preset distance below the detection position. That is, the sample stage 70 may be automatically lifted and lowered by the upgrade mechanism 60.

The microfluidic detection system 1 of the application is further provided with the lifting mechanism 60 which is used for driving the sample table 70 to move up and down between the detection position and the initial position which is located at the preset distance below the detection position, when sample is added, a user only needs to place the sample cup 2 on the sample table 70 when the sample table 70 is located at the initial position, the lifting mechanism 60 can automatically lift the sample table 70 to the detection position, the user does not need to continuously participate, and the automation degree of the microfluidic detection system 1 is improved. And, the initial position is in the preset distance below the detection position, and will not interfere with the microfluidic biochip 10 or other structures when placing the sample cup 2, further improving the convenience and comfort of operation.

Specifically, the detection position of the sample stage 70 is preferably such that the sample inlet 111 at the bottom of the microfluidic biochip 10 is adjacent to the sample stage 70, so that the sample inlet 111 extends into the bottom of the sample cup 2 when the sample cup 2 is placed on the sample stage 70, and even if the sample liquid in the sample cup 2 is relatively small, the sample inlet 111 can still be ensured to be in contact with the sample liquid. The initial position of the sample stage 70 is preferably at a distance from the sample inlet 111 at the bottom of the microfluidic biochip 10 that is greater than the height of the sample cup 2, thereby facilitating the user to place the sample cup 2 without interference.

Fig. 6 is a schematic structural diagram of the lifting mechanism and the sample stage in an assembled state according to an embodiment of the present invention, and fig. 7 is a schematic structural diagram of the lifting mechanism and the sample stage in a disassembled state according to an embodiment of the present invention. In some embodiments, the lift mechanism 60 may include a lift motor 61 and a drive screw 62. The lift motor 61 is used to output a driving force. The driving screw 62 is disposed in a vertical direction and connected to an output shaft of the elevating motor 61 to be rotated by the elevating motor 61. The sample stage 70 is disposed through the driving screw 62 and moves up and down along the driving screw 62 with the rotation of the driving screw 62.

Further, the driving screw 62 may be provided with threads, and the sample stage 70 may be directly screw-coupled to the driving screw 62 to move along the driving screw 62 when the driving screw 62 rotates. The sample stage 70 may also be indirectly connected to the drive screw 62 by other structures. For example, in a preferred embodiment, the lifting mechanism 60 further includes a nut 63, and the nut 63 is disposed on the transmission screw 62 and is threadedly coupled with the transmission screw 62 to move up and down along the transmission screw 62 with the rotation of the transmission screw 62. The sample stage 70 is fixedly connected with the nut 63 so as to drive the sample stage 70 to move up and down through the nut 63.

In some embodiments, the lift mechanism 60 further includes a slide rail 64 and a slider 65. The slide rails 64 are arranged parallel to the drive screw 62 on the side of the drive screw 62, i.e. the slide rails 64 also extend vertically and are arranged adjacent to the drive screw 62. The slide block 65 is movably arranged on the slide rail 64, and the sample table 70 is fixedly connected with the slide block 65 so as to guide the sample table 70 to move up and down through the matching of the slide rail 64 and the slide block 65. Specifically, the slide block 65 is driven to move synchronously when the sample stage 70 moves in the up-down direction under the action of the driving module, the slide block 65 is limited on the slide rail 64, and the slide rail 64 has guiding and limiting functions on the movement of the slide block 65, so that the sample stage 70 is indirectly guided and limited, the sample stage 70 is prevented from being shifted or stuck in the moving process, and the moving stability of the sample stage 70 is improved. Specifically, the sample stage 70 may include a horizontal connecting plate 74 penetrating the driving screw 62 and fixedly connected to the nut 63, and a vertical connecting plate 75 extending upward perpendicular to the horizontal connecting plate 74, the vertical connecting plate 75 being fixedly connected to the slide block 65.

In some embodiments, the lifting mechanism 60 further comprises a limit switch 66, and the limit switch 66 is disposed adjacent to the upper portion of the transmission screw 62 to cause the lifting motor 61 to stop operating when the sample stage 70 moves upward to touch the limit switch 66. And, the position of the limit switch 66 is set so that the sample stage 70 is in its detection position when the elevating motor 61 stops operating under the trigger of the limit switch 66. The elevating motor 61 is not operated to keep the sample stage 70 at its detecting position. The detection position of the sample table 70 is positioned through the limit switch 66, the positioning is accurate, and the problem that the sample table 70 exceeds the detection position to continuously move to cause the damage of the sample table 70, the microfluidic biochip 10 and other structures can be avoided.

It should be noted that in some alternative embodiments, the sample stage 70 may be fixed and the microfluidic biochip 10 may be configured to move, which may also facilitate the sampling operation.

In some embodiments, the microfluidic detection system 1 further comprises a buffer driving device 30, and the buffer driving device 30 is configured to drive a buffer into the sample cup 2 disposed on the sample stage 70, so that the buffer is mixed with the sample in the sample cup 2 to generate a sample solution. The method mainly aims at that a detected sample is a solid sample, and a buffer solution is needed to dissolve a substance to be detected on the solid sample into the solid sample so as to form a sample solution; alternatively, the sample is a liquid sample, but the concentration is too high, and it is necessary to dilute the sample with a buffer solution to produce a sample solution. For example, in the case of pesticide residue detection, the sample to be detected is usually a solid food residue such as epidermis or leaf, and the sample is placed in a buffer solution, and the pesticide residue on the sample is dissolved in the buffer solution to form a sample solution.

Further, the microfluidic detection system 1 further includes a buffer solution bottle 36 for containing the buffer solution, and the buffer solution bottle 36 is communicated with the buffer solution driving device 30 for providing the buffer solution for the buffer solution driving device 30. Specifically, the buffer solution bottle 36 is communicated with the buffer solution driving device 30 through the inlet tube 32. The extraction tube 31 of the buffer driving device 30 extends to the sample stage 70.

In particular, the buffer drive 30 may be a peristaltic pump, a diaphragm pump, or other suitable type of drive. The peristaltic or membrane pump generates a large vibration in its radial direction when it is operated, and in order to avoid that the vibration is transmitted to the microfluidic biochip 10, the radial outer side of the peristaltic or membrane pump may be provided with an elastic vibration reduction member 35. The elastic damping member 35 may be fitted over the outside of the buffer driving unit 30 and supported in the housing 80 by the clamping action of the bracket 87 and the fixing block 89, and the fixing block 89 may be fixed to the support plate 86.

In some embodiments, the buffer driving device 30 is disposed at a lateral side of the microfluidic biochip 10, the lifting mechanism 60 may be disposed below the buffer driving device 30 and at a lateral side of the sample stage 70, and the microfluidic biochip 10 is disposed above the sample stage 70, so that the layout of the four modules of the buffer driving device 30, the microfluidic biochip 10, the lifting mechanism 60 and the sample stage 70 is more compact, the occupied space is smaller, and the four modules are disposed side by side only in the vertical direction and the lateral direction, the thickness of the microfluidic detection system 1 in the front and back direction is reduced as much as possible, and the microfluidic detection system 1 is more suitable for being integrated on a refrigerator.

Further, a partition 861 extending transversely may be disposed between the buffer driving device 30 and the lifting mechanism 60 to prevent the buffer driving device 30 from leaking liquid and dropping on the lifting mechanism 60, which may affect the normal operation of the lifting mechanism 60. In particular, the partition 861 may be secured to the support plate 86, the support plate 86 being disposed within the housing 80 of the microfluidic detection system 1.

In some embodiments, the sample stage 70 may include a support stage 71 and an oscillator 72. The support stage 71 is for supporting the sample cup 2. Specifically, the supporting platform 71 may be a horizontally disposed supporting plate, and a groove for placing the bottom of the sample cup 2 therein may be disposed on the supporting plate, so as to prevent the sample cup 2 from toppling or shaking during the moving process of the sample platform 70, thereby improving the stability of placing the sample cup 2. The support table 71 is fixedly connected with the horizontal connecting plate 74.

The oscillator 72 is disposed on the supporting platform 71, and configured to oscillate the sample cup 2 after the sample cup 2 is placed on the supporting platform 71, so that the buffer solution in the sample cup 2 and the sample are sufficiently mixed, and the substance to be detected on the sample is sufficiently dissolved in the buffer solution to obtain a sample solution with a suitable concentration.

In some embodiments, the sample stage 70 further comprises a load cell 73, the load cell 73 being arranged below the support stage 71 for weighing the weight of the sample in the sample cup 2, thereby allowing the buffer drive 30 to deliver a preset amount of buffer matching the weight of the sample to the sample cup 2. Usually, the sample is taken at will by the home user, for example, a small piece of vegetable leaves is torn off at will, and therefore, in order to ensure the accuracy of the measurement result, the amount of the buffer solution input into the sample cup 2 needs to be matched with the amount of the sample, so as to generate the sample solution with proper concentration. The weight of the sample can be automatically and accurately obtained through the weighing sensor 73 arranged below the supporting table 71, so that the buffer solution driving device 30 is automatically controlled to input the matched amount of buffer solution into the sample cup 2, the accuracy of the measuring result is ensured, various problems of inconvenience in use, complex operation, large error and the like caused by manual measurement of the sample by a user are avoided, and the automation degree of the microfluidic detection system and the use experience of the user are further improved.

In some embodiments, the microfluidic detection system 1 further comprises a housing 80. The housing 80 has a console 83 formed thereon and opened toward the front side thereof, and the sample stage 70 is at least partially located in the console 83, thereby facilitating the user to perform operations of placing the sample cup 2, taking out the sample cup 2, and the like in the console 83. A water receiving box 88 may be disposed in the operation platform 83 below the sample platform 70 to receive liquid that may drip, so as to avoid contaminating the operation platform 83. At least some of the sections of the microfluidic biochip 10, the detection mechanism 20, the buffer solution bottle 36, and the buffer driving device 30 are disposed in the housing 80. Further, the housing 80 is provided with a first structural connection 81 for connecting with a cabinet or door of the refrigerator, and a first electrical connection 82 for forming an electrical connection between the microfluidic detection system 1 and an electrical control device of the refrigerator 100, so as to allow the microfluidic detection system 1 to be mounted to the cabinet or door of the refrigerator as a whole.

In some embodiments, the microfluidic biochip 10 is removably positioned above the sample stage 70, and the sample inlet 111 is positioned at the bottom of the microfluidic biochip 10. Further, the microfluidic detection system 1 further includes a chip mounting mechanism 51 and a chip ejection mechanism 52. The chip mounting mechanism 51 is disposed in the housing 80 and is used for supporting the microfluidic biochip 10. The chip withdrawing mechanism 52 is used to release the supporting function of the chip mounting mechanism 51 on the microfluidic biochip 10, so as to release the microfluidic biochip 10 and allow it to fall onto the sample stage 70 under its own weight. When the sample cup 2 is placed on the sample stage 70, the microfluidic biochip 10 can be automatically dropped into the sample cup 2 so as to be taken out and discarded together with the sample cup 2. Preferably, the chip withdrawing mechanism 52 may be exposed at the front side of the casing 80, and further exposed at the front side of the door 300, so as to facilitate the user to perform the chip withdrawing operation.

In some embodiments, the microfluidic detection system 1 further comprises a sample liquid driving device 40, and the sample liquid driving device 40 is in sealed communication with the communication port 112 through the connection pipeline 46 to promote the sample liquid in contact with the sample inlet 111 to flow into the microchannel 14 and to flow to the detection cell 121 through the microchannel 14. Specifically, the communication port 112, the detection cell 121 and the sample inlet 111 are sequentially communicated to form a main channel, and the sample liquid driving device 40 can drive the sample liquid contacting with the sample inlet 111 to enter the micro channel and the detection cell 121 under the action of negative pressure by sucking air outwards to form negative pressure in the main channel. Further, the sample liquid driving device 40 can be hermetically docked with the microfluidic biochip 10 by the hermetic docking mechanism 90, thereby ensuring that it is in sealed communication with the communication port 112. In particular, the sample fluid driving device 40 may be a micro syringe pump.

In some embodiments, the microfluidic detection system 1 further comprises a circuit board 53, a display device 56, and a switch button 57, the circuit board 53 being disposed within the housing 80 and electrically connected to the first electrical connector 82 on the housing 80. The electrical components (e.g., the lifting mechanism 60, the buffer driving device 30, the sample liquid driving device 40, the display device 56, the switch button 57, etc.) of the microfluidic detection system 1 are all directly or indirectly electrically connected to the circuit board 53. The display device 56 is disposed on the front side of the housing 80 and electrically connected to the circuit board 53 for displaying the detection result of the detection mechanism 20. The switch button 57 is disposed on the front side of the housing 80 and electrically connected to the circuit board 53 for activating and/or deactivating the detection function of the microfluidic detection system 1. That is, the user can activate, suspend, or deactivate the detection function of the microfluidic detection system 1 by operating the switch button 57.

In some embodiments, the housing 80 may include a rear case 84 at a rear side and a front panel 85 connected to a front side of the rear case 84. The rear housing 84 and the front panel 85 define a receiving cavity therebetween when assembled. Further, a support plate 86 and a bracket 87 are provided in the housing chamber of the housing 80. A support plate 86 is fixedly connected to the rear housing 84, and at least a portion of the structure of the lift mechanism 60 (e.g., the immovable portion of the lift mechanism 60) and the buffer driving device 30 are fixed to the support plate 86. The holder 87 is fixedly attached to the front side of the support plate 86, and both the microfluidic biochip 10 and the sample liquid driving device 40 are directly or indirectly supported on the holder 87. Thus, the elevating mechanism 60, the buffer driving device 30, the microfluidic biochip 10, and the sample liquid driving device 40 can be stably supported by the support plate 86 and the holder 87 in the accommodation chamber formed between the rear case 84 and the front panel 85.

In some embodiments, the lifting mechanism 60 may be disposed at a lateral side of the sample stage 70, the buffer driving device 30 may be disposed at one lateral side of the microfluidic biochip 10 and above the lifting mechanism 60, the sample liquid driving device 40 is disposed at the other lateral side of the microfluidic biochip 10, and the buffer bottle 36 is disposed at a side of the sample liquid driving device 40 facing away from the microfluidic biochip 10. The microfluidic biochip 10, the sample stage 70, the lifting mechanism 60, the buffer driving device 30, the sample liquid driving device 40 and the buffer liquid bottle 36 which are arranged in this way fully utilize the dimensional characteristics of each module in the vertical direction and the transverse direction, so that the arrangement of each module is more compact, and the occupied space is reduced as much as possible. Moreover, the modules are arranged side by side only in the vertical direction and the transverse direction, so that the thickness of the microfluidic detection system 1 in the front and rear directions is reduced as much as possible, and the microfluidic detection system is more suitable for being integrated on a refrigerator.

The utility model provides a refrigerator, figure 8 is according to the utility model discloses a schematic structure chart of refrigerator of an embodiment. The refrigerator 100 of the present invention includes the microfluidic detection system 1 according to any of the above embodiments to integrate the microfluidic detection system 1 into the refrigerator 100. The refrigerator 100 is frequently used in daily life, and the refrigerator 100 is mainly used for storing food materials, so that when the microfluidic detection system 1 is integrated on the refrigerator 100, a user can conveniently perform a detection operation of a food material sample by using the microfluidic detection system 1.

Further, the refrigerator 100 further includes a cabinet 200 and a door 300, wherein the cabinet 200 defines a storage space therein, and the door 300 is connected to the cabinet 200 and is used for opening and/or closing the storage space. The micro-fluidic detection system 1 is preferably arranged on the door 300, so that the operation is convenient, the original storage space in the refrigerator body 200 cannot be occupied, and the storage capacity of the refrigerator 100 cannot be influenced.

Fig. 9 is a schematic exploded view of a door body according to an embodiment of the present invention. In some embodiments, the hollow window 301 is disposed on the front side of the door 300, and the sample stage 70 of the microfluidic detection system 1 is exposed to the front side of the door 300 through the hollow window 301, so that a user can place a sample cup on the sample stage 70 without opening the door 300, the problem of serious cold leakage caused by opening the door 300 during each detection is avoided, the heat preservation performance of the refrigerator 100 is ensured, and energy consumption is reduced.

Specifically, the door body 300 may include a panel 302 for forming a front portion thereof, a door liner 303 for forming a rear portion thereof, and a foam insulation layer (not shown) disposed between the panel 302 and the door liner 303, and the cutout window 301 is opened on the panel 302. An embedded box 304 is embedded between the panel 302 and the door liner 303 before the foaming heat-insulating layer is formed, and the microfluidic detection system 1 is arranged in the embedded box 304. That is, the pre-embedded box 304 is pre-arranged between the panel 302 and the door liner 303 before the door 300 is foamed, so as to reserve a space for installing the microfluidic detection system 1 between the panel 302 and the door liner 303.

Further, the embedded box 304 is attached to the rear surface of the panel 302, the front side of the embedded box 304 is open and faces the hollow window 301, so that the micro-fluidic detection system 1 is allowed to be installed into the embedded box 304 from front to back through the hollow window 301, and the installation convenience of the micro-fluidic detection system 1 is improved.

Specifically, the embedded box 304 may be provided with a second structure connector 305 connected to the first structure connector 81 in a matching manner and a second electrical connector 306 electrically connected to the first electrical connector 82, and the second electrical connector 306 is electrically connected to the electric control device of the refrigerator 100. Therefore, the micro-fluidic detection system 1 is integrally mounted on the door 300 by arranging corresponding structural connecting pieces and electrical connecting pieces on the embedded box 304 and the shell 80, so that the connection between the whole micro-fluidic detection system 1 and the refrigerator 100 is realized in both structural and circuit aspects. Therefore, the assembly process of the microfluidic detection system 1 is simplified, and the disassembly or the maintenance of the microfluidic detection system 1 is facilitated.

The refrigerator 100 of the present application is a refrigerator in a broad sense, and includes not only a so-called refrigerator in a narrow sense but also a storage device having a refrigerating, freezing or other storage function, for example, a refrigerator, a freezer, and the like.

It should be further understood by those skilled in the art that the terms "upper", "lower", "front", "back", "top", "bottom", etc. used in the embodiments of the present invention are used as terms of orientation or positional relationship with respect to the actual use state of the micro-fluidic detection system 1 and the refrigerator 100, and these terms are only used for convenience of description and understanding of the technical solution of the present invention, and do not indicate or imply that the device referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as limiting the present invention.

Thus, it should be appreciated by those skilled in the art that while a number of exemplary embodiments of the invention have been shown and described in detail herein, many other variations and modifications can be made, consistent with the principles of the invention, which are directly determined or derived from the disclosure herein, without departing from the spirit and scope of the invention. Accordingly, the scope of the present invention should be understood and interpreted to cover all such other variations or modifications.

Claims (10)

1. A microfluidic detection system for a refrigerator, comprising:

the sample table is used for placing a sample cup, and the sample cup is used for containing a sample liquid;

a microfluidic biochip having a sample inlet, a communication port, and a detection cell formed therein, the sample inlet, the detection cell, and the communication port being sequentially communicated through a microchannel, thereby allowing a sample liquid contacting the sample inlet to flow into the microchannel and flow into the detection cell through the microchannel;

the detection mechanism is used for detecting the detection cell to obtain preset detection parameters of the sample liquid; wherein

The sample stage is configured for controlled or operable movement to transport a sample cup placed thereon through the sample stage to a position that allows the sample fluid in the sample cup to contact a sample inlet of the microfluidic biochip.

2. The microfluidic detection system of claim 1,

the microfluidic biochip is fixedly arranged above the sample stage, and the sample inlet is positioned at the bottom of the microfluidic biochip; and is

The microfluidic detection system also comprises a lifting mechanism for driving the sample stage to move up and down, so that the sample stage is switched between a detection position allowing sample liquid in a sample cup placed on the sample stage to be in contact with the sample inlet and an initial position which is a preset distance below the detection position.

3. The microfluidic detection system of claim 2, wherein the lifting mechanism comprises:

a lift motor for outputting a driving force; and

the transmission screw rod is arranged in the vertical direction and is connected with an output shaft of the lifting motor so as to rotate under the driving of the lifting motor; wherein

The sample table penetrates through the transmission screw rod and moves up and down along the transmission screw rod along with the rotation of the transmission screw rod.

4. The microfluidic detection system of claim 3, wherein the lifting mechanism further comprises:

the nut is arranged on the transmission screw rod in a penetrating mode, is in threaded connection with the transmission screw rod and moves up and down along the transmission screw rod along with the rotation of the transmission screw rod; wherein

The sample stage is fixedly connected with the nut so as to drive the sample stage to move up and down through the nut.

5. The microfluidic detection system of claim 3, wherein the lifting mechanism further comprises:

the sliding rail is arranged beside the transmission screw rod in parallel with the transmission screw rod;

the sliding block is movably arranged on the sliding rail; wherein

The sample table is fixedly connected with the sliding block so as to guide the sample table to move up and down through the matching of the sliding rail and the sliding block.

6. The microfluidic detection system of claim 3, wherein the lifting mechanism further comprises:

the limit switch is arranged close to the upper part of the transmission screw rod and used for prompting the lifting motor to stop running when the sample table moves upwards to touch the limit switch; and is

The position of the limit switch is set to enable the sample stage to be at the detection position when the lifting motor stops running under the trigger of the limit switch.

7. The microfluidic detection system of claim 1, further comprising:

and the buffer driving device is used for driving a buffer into the sample cup arranged on the sample table, so that the buffer is mixed with the sample in the sample cup to generate the sample liquid.

8. The microfluidic detection system of claim 7, wherein the sample stage comprises:

a support table for supporting the sample cup; and

the oscillator is arranged on the supporting platform and used for oscillating the sample cup after the sample cup is placed on the supporting platform, so that the buffer solution in the sample cup is fully mixed with the sample.

9. The microfluidic detection system of claim 8, wherein the sample stage further comprises:

and the weighing sensor is arranged below the supporting table and used for measuring the weight of the sample, so that the buffer driving device is allowed to convey a preset amount of buffer matched with the weight of the sample to the sample cup.

10. A refrigerator comprising a microfluidic detection system according to any one of claims 1 to 9.

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