CN116159607A - Microfluidic detection system for refrigerator and refrigerator - Google Patents
Microfluidic detection system for refrigerator and refrigerator Download PDFInfo
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- CN116159607A CN116159607A CN202111414287.9A CN202111414287A CN116159607A CN 116159607 A CN116159607 A CN 116159607A CN 202111414287 A CN202111414287 A CN 202111414287A CN 116159607 A CN116159607 A CN 116159607A
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- 230000007246 mechanism Effects 0.000 claims abstract description 37
- 238000007789 sealing Methods 0.000 claims abstract description 21
- 238000000034 method Methods 0.000 claims abstract description 12
- 230000008569 process Effects 0.000 claims abstract description 10
- 238000003825 pressing Methods 0.000 claims description 13
- 230000005489 elastic deformation Effects 0.000 claims description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 3
- 238000000071 blow moulding Methods 0.000 claims description 3
- 238000001746 injection moulding Methods 0.000 claims description 3
- 239000000741 silica gel Substances 0.000 claims description 3
- 229910002027 silica gel Inorganic materials 0.000 claims description 3
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D23/00—General constructional features
- F25D23/12—Arrangements of compartments additional to cooling compartments; Combinations of refrigerators with other equipment, e.g. stove
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
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- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The invention relates to a microfluidic detection system for a refrigerator and the refrigerator. The microfluidic detection system comprises: the microfluidic biochip is provided with a sample inlet, an air suction port formed at the end part of the microfluidic biochip and a detection pool formed inside the microfluidic biochip, wherein the sample inlet, the detection pool and the air suction port are communicated in sequence; an elastic air bag configured to be in sealing contact with an end portion of the microfluidic biochip, the end portion being formed with the air inlet, an inner space of the elastic air bag being communicated with the air inlet; the sample liquid driving device is configured to controllably squeeze and release the elastic air bag so as to promote the sample liquid contacted with the sample inlet to enter the micro-flow channel and flow to the detection pool through the micro-flow channel in the process of recovering deformation of the elastic air bag; and the detection mechanism is used for detecting the detection pool. The invention controls the deformation of the elastic air bag through the sample liquid driving device so as to control the liquid suction and the air displacement, thereby not only eliminating the air tightness problem between the sample liquid driving device and the microfluidic biochip, but also maintaining the accuracy of sample injection control.
Description
Technical Field
The invention relates to a refrigeration technology, in particular to a microfluidic detection system for a refrigerator and the refrigerator.
Background
With the improvement of the living standard of people, pesticide residues, viruses, nutrient elements or other aspects of edible materials are generally required to be detected in daily life so as to qualitatively or quantitatively acquire the condition of the edible materials. For example, due to the problem of pesticide abuse, the daily purchased fruits and vegetables and agricultural and sideline products may have the problem of exceeding the pesticide residue content, and if the problem of exceeding the pesticide residue content of the foods cannot be timely found, the foods can cause great harm after being ingested by human bodies. For another example, breast feeding currently advocated is best feeding infants only if breast milk has normal nutritional value, however, the reduction of the content of nutrients in milk secreted by the infants and even the production of viruses may occur in the event of a sick, eaten, operated or otherwise by the lactating mother, thereby affecting the growth and health of the infants. The existing household appliances are single in function, and when pesticide residues, viruses, nutrient elements or other aspects of edible food materials are required to be detected, separate detection devices are required to be purchased, so that the quantity and the variety of the household appliances are various, the occupied space is large, and the intelligent household appliance does not accord with the development trend of intelligent families.
Among the detection methods, the method for detecting by using the microfluidic biochip is rapid, has small volume and is suitable for household use. In order to push the movement of the fluid in the chip, there are generally both pneumatic pushing and centrifugal pushing. Wherein centrifugal force pushing pushes liquid drops to flow by means of rotating centrifugal force, and unidirectional flow action can be regulated only by regulating the rotating speed. The air pressure pushing type utilizes positive and negative air pressure to bidirectionally push the fluid to move in the chip, and has high precision and strong controllability. However, when the air suction port of the chip is in butt joint with the air suction pipe of the pushing mechanism, the problems of unstable air tightness and unreliable caused by various reasons such as insufficient pressing area, uneven pressing surface, insufficient pressing force and insufficient precision of the piston of the injection pump can be avoided. To date, air tightness by air pressure pushing is still a technical problem which is not completely and effectively solved.
Disclosure of Invention
An object of the first aspect of the present invention is to overcome at least one of the drawbacks of the prior art, and to provide a microfluidic detection system with good sealing performance and accurate sample injection control, which is suitable for refrigerators.
A further object of the first aspect of the invention is to simplify the assembly operations on the basis of ensuring good tightness.
An object of a second aspect of the present invention is to provide a refrigerator having the microfluidic detection system described above.
According to a first aspect of the present invention there is provided a microfluidic detection system for a refrigerator comprising:
the microfluidic biochip is provided with a sample inlet, an air suction port formed at the end part of the microfluidic biochip and a detection pool formed in the microfluidic biochip, wherein the sample inlet, the detection pool and the air suction port are sequentially communicated through a micro-channel;
an elastic air bag configured to be in sealing contact with an end portion of the microfluidic biochip where the air inlet is formed, an internal space of the elastic air bag communicating with the air inlet;
a sample liquid driving device configured to controllably squeeze and release the elastic air bag so as to promote the sample liquid in contact with the sample inlet to enter the micro flow channel and flow to the detection pool through the micro flow channel in the process of recovering deformation of the elastic air bag; and
and the detection mechanism is used for detecting the detection pool so as to obtain preset detection parameters of the sample liquid.
Optionally, the elastic air bag is hermetically sleeved outside the end part of the microfluidic biochip, where the air suction port is formed.
Optionally, the elastic air bag is provided with a spherical air bag part and a connecting end for connecting with the microfluidic biochip; and is also provided with
The sample liquid driving device is configured to apply opposing pressing forces to the spherical balloon portion from opposite directions to cause elastic deformation of the spherical balloon portion.
Optionally, the sample inlet is formed at a bottom port of the microfluidic biochip, the air suction port is formed at a top port of the microfluidic biochip, and the elastic air bag is connected above the microfluidic biochip and is hermetically sleeved at the outer side of the top port; and is also provided with
The sample liquid driving device is configured to controllably apply a squeezing force parallel to a horizontal plane to the spherical air bag portion.
Optionally, the sample liquid driving device includes:
a driving motor for controllably outputting a driving force;
the screw is connected with the output shaft of the driving motor and is used for rotating under the drive of the driving motor; the screw is provided with a forward thread section and a reverse thread section, and the forward thread section and the reverse thread section are respectively provided with forward threads and reverse threads with opposite directions; and
the two sliding blocks are sleeved on the screw rod and are respectively in threaded connection with the forward thread section and the reverse thread section so as to move towards or away from each other when the screw rod rotates; and is also provided with
The two sliding blocks are respectively positioned on two opposite sides of the elastic air bag.
Optionally, the microfluidic detection system further comprises:
the mounting mechanism is provided with a mounting groove for plugging the microfluidic biochip and a cavity for accommodating the elastic air bag, and the notch of the mounting groove and the opening of the cavity face the same direction; and is also provided with
The microfluidic biochip and the elastic air bag are integrally arranged in the mounting mechanism through the notch of the mounting groove and the opening of the cavity, so that the microfluidic biochip is inserted into the mounting groove, the elastic air bag is accommodated in the cavity, and the sample inlet of the microfluidic biochip is positioned outside the mounting groove.
Optionally, the sample inlet is formed at a bottom port of the microfluidic biochip, the air suction port is formed at a top port of the microfluidic biochip, and the elastic air bag is connected above the microfluidic biochip and is hermetically sleeved at the outer side of the top port; and is also provided with
The mounting groove extends vertically, the cavity is connected above the mounting groove, and the whole formed by the microfluidic biochip and the elastic air bag is configured to be mounted to the mounting mechanism along a direction parallel to a horizontal plane.
Optionally, the size of the mounting groove is smaller than the size of the cavity so as to form a step part at the boundary of the mounting groove and the cavity; and is also provided with
The size of the top port of the microfluidic biochip in the thickness direction of the microfluidic biochip is larger than the thickness of the microfluidic biochip, and the bottom of the top port is abutted to the step part.
Optionally, the mounting mechanism further has at least one gripping member disposed within the mounting slot, the gripping member configured to grip the microfluidic biochip after insertion into the mounting slot.
Optionally, the clamping member comprises two symmetrical clamping jaws arranged at intervals, and the two clamping jaws are configured to apply opposite elastic forces to two opposite side surfaces of the microfluidic biochip after the microfluidic biochip is mounted to the mounting groove.
Optionally, the microfluidic biochip is formed by injection molding; and/or
The elastic air bag is formed by silica gel or PE blow molding.
According to a second aspect of the present invention, the present invention further provides a refrigerator, which includes the microfluidic detection system according to any one of the above schemes.
According to the invention, the end part of the microfluidic biochip, which is provided with the air suction port, is particularly connected with the elastic air bag in a sealing way, a communication pipeline is not needed between the sample liquid driving device and the microfluidic biochip, and simple mechanical extrusion is only performed, namely, the air tightness problem is completely avoided between the sample liquid driving device and the microfluidic biochip, so that the air tightness problem between the sample liquid driving device and the microfluidic biochip is transferred to the air tightness problem between the elastic air bag and the end part of the microfluidic biochip. It can be understood that the sealing between the microfluidic biochip and the sample liquid driving device is completed during or after the installation of the microfluidic biochip, the restrictions on the operation space and the operation mode are relatively large, and the sealing effect cannot be ensured. The sealing butt joint between the elastic air bag and the microfluidic biochip is completed before the microfluidic biochip is installed, and the limitation of an operation space and a sealing mode is avoided, so that the elastic air bag and the microfluidic biochip can be effectively and well sealed. In addition, the deformation of the elastic air bag is controlled through the sample liquid driving device so as to control the liquid suction and the air displacement, so that the problem of air tightness between the sample liquid driving device and the microfluidic biochip is solved, and the accuracy of sample injection control is maintained.
Further, the inventors have recognized that since the elastic balloon has elastic expansion and contraction properties, it is possible to use the properties to form a sealed connection between the elastic balloon and the end of the microfluidic biochip. Therefore, the elastic air bag is hermetically sleeved outside the end part of the microfluidic biochip, which is provided with the air suction port, and tightly binds the microfluidic biochip, so that the assembly connection between the microfluidic biochip and the microfluidic biochip is simply realized, and the sealing between the microfluidic biochip and the microfluidic biochip is ensured.
According to the invention, the microfluidic detection system is integrated on the refrigerator, so that the storage function of the refrigerator is fully utilized, the detection process is more convenient, the microfluidic detection system and the refrigerator are convenient to carry out linkage control, the intelligent degree is higher, and the requirements of smart families are met.
The above, as well as additional objectives, advantages, and features of the present invention will become apparent to those skilled in the art from the following detailed description of a specific embodiment of the present invention when read in conjunction with the accompanying drawings.
Drawings
Some specific embodiments of the invention will be described in detail hereinafter by way of example and not by way of limitation with reference to the accompanying drawings. The same reference numbers will be used throughout the drawings to refer to the same or like parts or portions. It will be appreciated by those skilled in the art that the drawings are not necessarily drawn to scale. In the accompanying drawings:
fig. 1 is a schematic block diagram of a microfluidic detection system for a refrigerator according to one embodiment of the present invention;
fig. 2 is a schematic structural view of an internal structure of a microfluidic detection system according to one embodiment of the present invention;
fig. 3 is a schematic view of a partial structure of a microfluidic detection system according to an embodiment of the present invention;
fig. 4 is a schematic exploded view of a part of the structure of a microfluidic detection system according to one embodiment of the present invention;
fig. 5 is a schematic cross-sectional view of a microfluidic biochip and an elastic balloon according to one embodiment of the invention;
FIG. 6 is a schematic structural exploded view of a microfluidic biochip and an elastic balloon according to one embodiment of the invention;
fig. 7 is a schematic structural view of a refrigerator according to an embodiment of the present invention.
Detailed Description
The invention firstly provides a micro-fluidic detection system for a refrigerator, which is used for qualitatively or quantitatively detecting preset detection parameters of a sample liquid, wherein the preset detection parameters can be pesticide residue parameters used for indicating whether the pesticide residue exceeds a standard and/or specific numerical values of the pesticide residue, nutrition parameters used for indicating whether the nutritional elements reach standards and/or specific contents of the nutritional elements, specific substance parameters used for indicating whether specific harmful substances (such as specific viruses) exceed the standard and/or specific contents, and the like.
Fig. 1 is a schematic structural view of a microfluidic detection system for a refrigerator according to one embodiment of the present invention, fig. 2 is a schematic structural view of an internal structure of the microfluidic detection system according to one embodiment of the present invention, fig. 3 is a schematic view of a partial structure of the microfluidic detection system according to one embodiment of the present invention, and fig. 4 is a schematic exploded view of a partial structure of the microfluidic detection system according to one embodiment of the present invention. For ease of understanding, the sample cup 2 is also shown in fig. 1-2.
Referring to fig. 1 to 4, the microfluidic detection system 1 of the present invention includes a microfluidic biochip 10, an elastic balloon 60, a sample liquid driving device 40, and a detection mechanism 20.
Fig. 5 is a schematic cross-sectional view of a microfluidic biochip and an elastic balloon according to an embodiment of the present invention, and fig. 6 is a schematic structural exploded view of a microfluidic biochip and an elastic balloon according to an embodiment of the present invention. The microfluidic biochip 10 has a sample inlet 111, a suction port 112 formed at an end portion thereof, and a detection cell 113 formed inside thereof, and the sample inlet 111, the detection cell 113, and the suction port 112 are sequentially communicated through a micro flow channel 114, thereby forming a main channel. The elastic air bag 60 is disposed in sealing contact with the end of the microfluidic biochip 10 where the air inlet 112 is formed, and the internal space of the elastic air bag 60 communicates with the air inlet 112. The sample liquid driving device 40 is configured to controllably squeeze and release the elastic air bag 60 to urge the sample liquid in contact with the sample inlet 111 into the micro flow channel 114 and flow to the detection cell 113 through the micro flow channel 114 during the recovery deformation of the elastic air bag 60. The detection mechanism 20 is used for detecting the detection cell 113 to obtain preset detection parameters of the sample liquid. Specifically, a detection reagent may be provided in the detection cell 113 to detect the detection cell 113 by the detection mechanism 20 after the reaction of the sample liquid in the detection cell 113 and the detection reagent therein.
The microfluidic detection system 1 of the present invention comprises a microfluidic biochip 10 and an elastic airbag 60 in sealing connection with the end of the microfluidic biochip 10 where an air inlet 112 is formed, the internal space of the elastic airbag 60 is communicated with the air inlet 112 of the microfluidic biochip 10, thereby forming a closed space between the microfluidic biochip 10 and the elastic airbag 60, and only a port for sample introduction is reserved at the sample introduction port 111. The sample liquid driving device 40 discharges air in the microfluidic biochip 10 by pressing the elastic air bag 60, and when the elastic air bag 60 is released by the sample liquid driving device 40, the elastic air bag 60 resumes its shape change, thereby causing the sample liquid in contact with the sample inlet 111 to enter the detection cell in the microfluidic biochip 10.
The end part of the microfluidic biochip 10, on which the air suction port 112 is formed, is particularly connected with the elastic air bag 60 in a sealing manner, a communication pipeline is not needed between the sample liquid driving device 40 and the microfluidic biochip 10, and simple mechanical extrusion is only performed, namely, the air tightness problem is completely avoided between the sample liquid driving device 40 and the microfluidic biochip 10, so that the air tightness problem between the elastic air bag 60 and the end part of the microfluidic biochip 10 is transferred. It can be understood that the sealing between the microfluidic biochip 10 and the sample liquid driving device 40 is completed when or after the microfluidic biochip 10 is mounted, and the limitation of the operation space and the operation mode is relatively large, so that the sealing effect cannot be ensured. The sealing and butt joint between the elastic air bag 60 and the micro-fluidic biochip 10 is completed before the micro-fluidic biochip 10 is installed, and the limitation of an operation space and a sealing mode is avoided, so that the elastic air bag 60 and the micro-fluidic biochip 10 can be effectively and well sealed. In addition, the deformation of the elastic air bag 60 is controlled by the sample liquid driving device 40 so as to control the liquid suction and the air discharge, so that the problem of air tightness between the sample liquid driving device 40 and the microfluidic biochip 10 is solved, and the accuracy of sample injection control is maintained.
It will be appreciated by those skilled in the art that the particular choice of microfluidic biochip 10 and detection mechanism 20 used may vary when the preset detection parameters for the microfluidic detection system are different. For example, when the microfluidic detection system is used for pesticide residue detection, the microfluidic biochip 10 may be a microfluidic pesticide residue detection chip capable of providing detection conditions for pesticide residue, and the detection mechanism 20 may be a pesticide residue detection mechanism capable of detecting pesticide residue parameters of pesticide residue.
In one particular embodiment, when the detection mechanism 20 is an agricultural residue detection mechanism for detecting agricultural residue parameters of agricultural residue, an enzyme inhibition method may be used to rapidly and qualitatively detect whether the agricultural residue of the sample liquid exceeds the standard. At this time, the microfluidic biochip 10 further includes a reaction cell 115 formed therein, and the reaction cell 115 is located on a main channel formed by sequentially communicating the sample inlet 111, the detection cell 113, and the air inlet 112, and is communicated between the sample inlet 111 and the detection cell 113, so that the sample solution reacts with the reaction reagent in the reaction cell 115 before flowing into the detection cell 113. The reaction tank 115 and the sample inlet 111 and the reaction tank 115 and the detection tank 113 are communicated through the micro-channel 114. The reaction reagent and the detection reagent for pesticide residue detection can be respectively an enzyme reagent and a color reagent. The reaction cell 115 is used for reacting the sample liquid with the enzyme reagent therein, and the sample liquid after reacting with the enzyme reagent flows into the detection cell 113 to react with the color-developing agent in the detection cell 113. The detection mechanism 20 may alternatively be a photoelectric detection mechanism, which may include a light source, a photosensitive element, a heating plate, a temperature controller, and the like.
The inventors have recognized that since the elastic balloon 60 has elastic expansion and contraction properties, it is possible to use the properties to form a sealed connection between the elastic balloon 60 and the end of the microfluidic biochip 10. For this reason, in some embodiments, the elastic balloon 60 is hermetically sleeved outside the end portion of the microfluidic biochip 10 where the suction port 112 is formed, and the elastic balloon 60 tightly binds the microfluidic biochip 10, not only simply realizing the fitting connection therebetween, but also ensuring the sealing therebetween.
Further, the microfluidic biochip 10 may be molded using an injection molding process to facilitate the addition of reagents in its detection cell 113 and reaction cell 115.
Further, the elastic air bag 60 can be formed by silica gel molding or PE blow molding, and the elastic air bag made of the material has good elastic deformation capability and strong deformation recovery capability, and is very suitable for promoting the fluid flow in the micro-channel.
In some embodiments, the elastic balloon 60 has a spherical balloon portion 61 and a connection end 62 for connection with the microfluidic biochip 10. The sample liquid driving device 40 is configured to apply opposing pressing forces from opposite directions to the spherical balloon portion 61 of the elastic balloon 60 to cause elastic deformation of the spherical balloon portion 61. Therefore, the elastic air bag 60 receives more balanced acting force from the sample liquid driving device 40, so that the deformation of the elastic air bag is more uniform and easier to control, and the accurate control of the liquid inlet amount is realized by controlling the deformation of the elastic air bag 60.
More importantly, if the spherical air bag portion 61 receives unbalanced force, the spherical air bag portion 61 deforms and the center thereof is inclined from the original position, which causes the connection between the elastic air bag 60 and the microfluidic biochip 10 to shift to affect the sealing effect between the two, and even causes the elastic air bag 60 to separate from the microfluidic biochip 10. The sample liquid driving device 40 according to the present invention applies opposing pressing forces to the spherical air bag portion 61 from opposite directions, and during the pressing process, the spherical air bag portion 61 deforms, but the position of the center thereof remains unchanged, so that the sealing effect between the elastic air bag 60 and the sample liquid driving device 40 is not affected.
In some embodiments, the sample inlet 111 is formed at the bottom port of the microfluidic biochip 10, the air suction port 112 is formed at the top port 12 of the microfluidic biochip 10, and the elastic balloon 60 is connected above the microfluidic biochip 10 and hermetically sleeved outside the top port 12. Further, the sample liquid driving device 40 is configured to controllably apply a pressing force parallel to the horizontal plane to the spherical balloon portion 61. The applicant has appreciated that the elastic balloon 60 has a connection end 62 connected to the microfluidic biochip 10, the connection end 62 corresponding to one pole of the spherical balloon portion 61, and an upper end of the spherical balloon portion 61 opposite to the connection end corresponding to the other pole of the spherical balloon portion 61, and therefore, the spherical balloon portion 61 is more likely to be deformed in its equatorial direction parallel to the horizontal direction, and the spherical balloon portion 61 is more likely to recover the deformation after the deformation in that direction. Therefore, the sample liquid driving device 40 applies the pressing force parallel to the horizontal plane to the spherical bubble portion 61 to facilitate the deformation and recovery of the deformation of the spherical bubble portion 61.
In some embodiments, the sample fluid drive device 40 specifically includes a drive motor 41, a screw 42, and two slides 43. The driving motor 41 is for controllably outputting driving force. The screw 42 is connected to an output shaft of the driving motor 41, and is used for rotating under the driving of the driving motor 41. The screw 42 has a forward threaded section and a reverse threaded section with forward and reverse threads, respectively, in opposite directions. The two sliders 43 are sleeved on the screw 42 and are respectively screwed with the forward thread section and the reverse thread section of the screw 42 to move toward or away from each other when the screw 42 rotates. The two sliders 43 are located on opposite sides of the elastic balloon 60, respectively.
Specifically, when the driving motor 41 is controlled to rotate forward, the screw 42 rotates forward, and the two sliders 43 can translate on the screw 42 in directions toward each other, thereby pressing the elastic balloon 60 in directions toward each other, causing the elastic balloon 60 to deform. When the drive motor 41 is controllably reversed, the screw 42 is counter-rotated and the two slides 43 can translate on the screw 42 in directions away from each other, releasing the elastic balloon 60. The elastic balloon 60 recovers its deformation by its elastic deformation restoring force. Thus, the sample liquid driving device 40 can stably and finely control the sliding of the two sliders 43 by the driving motor 41, thereby accurately and reliably controlling the deformation amount of the elastic balloon 60.
In some embodiments, the microfluidic detection system 1 further comprises a mounting mechanism 30. The applicant has realized that, since there is no air tightness problem between the microfluidic biochip 10 and the sample liquid driving device 40, that is, the sealing and abutting structure between the microfluidic biochip 10 and the sample liquid driving device 40 is not required to be considered when the microfluidic biochip 10 is mounted, it is only required to ensure that the microfluidic biochip 10 is stably and reliably mounted. Therefore, the mounting mechanism 30 of the present invention does not need to be designed into a very complex structure, and only needs to be able to hold the microfluidic biochip 10.
For this purpose, the mounting mechanism 30 of the present invention has a mounting groove 31 for inserting the microfluidic biochip 10 and a cavity 32 for accommodating the elastic balloon 60, and the notch of the mounting groove 31 and the opening of the cavity 32 face in the same direction. The whole of the microfluidic biochip 10 and the elastic airbag 60 is mounted into the mounting mechanism 30 through the notch of the mounting groove 31 and the opening of the cavity 32 so that the microfluidic biochip 10 is inserted into the mounting groove 31 and the elastic airbag 60 is accommodated in the cavity 32, not only achieving effective mounting of the microfluidic biochip 10, but also simplifying the structure of the microfluidic detection system 1 to a great extent.
Further, the sample inlet 111 of the microfluidic biochip 10 is located outside the mounting groove 31 to facilitate the sample inlet 111 to suck the sample liquid when the microfluidic biochip 10 is in a mounted state.
Further, the sample liquid driving device 40 may be supported on the mounting mechanism 30 with its two sliders 43 also positioned in the cavity 32 so as to press the elastic balloon 60.
In some embodiments, the sample inlet 111 is formed at the bottom port of the microfluidic biochip 10, the air suction port 112 is formed at the top port 12 of the microfluidic biochip 10, and the elastic balloon 60 is connected above the microfluidic biochip 10 and hermetically sleeved outside the top port 12. Since the elastic balloon 60 is elastically contractible and deformable, the microfluidic biochip 10 is not easily installed from bottom to top.
To this end, the present invention further provides that the mounting groove 31 is provided to extend vertically, the cavity 32 is connected above the mounting groove 31, and the microfluidic biochip 10 and the elastic balloon 60 are integrally configured to be mounted to the mounting mechanism 30 in a direction parallel to the horizontal plane. That is, the elastic balloon 60 is installed in parallel with the microfluidic biochip 10, the elastic balloon 60 does not cause any obstruction or influence on the assembly of the microfluidic biochip 10, and at the same time, the microfluidic biochip 10 is only held stationary in the mounting groove 31 by the structural design of the mounting groove 31 and the cavity 32, allowing the elastic balloon 60 to elastically deform in the cavity 32 without obstruction.
In some embodiments, the size of the mounting groove 31 is smaller than the size of the cavity 32 to form a step 33 at the interface of the mounting groove 31 and the cavity 32. The size of the top port 12 of the microfluidic biochip 10 in the thickness direction of the microfluidic biochip 10 is larger than the thickness of the microfluidic biochip 10, so that the bottom of the top port 12 abuts against the step 33 to avoid the microfluidic biochip 10 from falling down. Thereby, the microfluidic biochip 10 and the elastic airbag 60 can be supported together at the step 33, achieving positioning of the microfluidic biochip 10 in the vertical direction. The present invention positions the microfluidic biochip 10 in a vertical direction using a simple design of the structural dimensions of the mounting groove 31 and the cavity 32, and has a very simple structure.
In some embodiments, the mounting mechanism 30 further has at least one clamping member 34 disposed in the mounting groove 31, and the clamping member 34 is configured to clamp the microfluidic biochip 10 after the microfluidic biochip 10 is inserted into the mounting groove 31, so as to avoid tilting, shaking or separating the microfluidic biochip 10 from the mounting groove 31 during the process of pressing or releasing the elastic air bag 60 by the sample liquid driving device 40, thereby limiting the microfluidic biochip 10 in the horizontal direction.
Specifically, the mounting groove 31 may have a receiving space formed therein for receiving the clamping member 34, and the clamping member 34 is restricted in the receiving space and can be elastically deformed within a certain range to maintain a preferable clamping force to the chip body 11.
Further, the clamping member 34 includes two symmetrical and spaced clamping jaws 341, and the two clamping jaws 341 are configured to apply elastic forces in opposite directions to two opposite side surfaces of the microfluidic biochip 10, respectively, after the microfluidic biochip 10 is mounted to the mounting groove 31, thereby more stably holding the microfluidic biochip 10.
In some embodiments, the microfluidic detection system 1 further comprises a weighing station 81 and a carriage 82. The weighing stage 81 is fixedly arranged on a support 83 and serves to measure the weight of a sample contained in the sample cup 2 placed thereon. It will be appreciated that the weighing station 81 may measure the sum of the weights of the sample cup 2 and the sample contained therein, and subtract the weight of the sample cup 2 itself to obtain the weight of the sample. The weighing station 81 may also be arranged to directly detect the weight of the sample contained in the sample cup 2, for example a peeling measurement. The carriage 82 is configured to controllably or operatively move to bring the sample cup 2 into a highest position allowing sample fluid in the sample cup 2 to contact the sample inlet 111 of the microfluidic biochip 10.
In some embodiments, the microfluidic detection system 1 further comprises a buffer bottle 51 and a buffer drive 52. The buffer bottle 51 is for containing a buffer. The buffer driving device 52 is in communication with the buffer bottle 51 to controllably drive the buffer in the buffer bottle 51 into the sample cup 2 placed on the weighing table 81, so that the buffer is mixed with the sample in the sample cup 2 to generate the sample liquid. In particular, buffer drive 52 may be a peristaltic pump, a diaphragm pump, or other suitable type of drive.
In some embodiments, the microfluidic detection system 1 further comprises a housing 90. The housing 90 has formed thereon an operation table open toward a front side thereof, and the weighing table 81 is at least partially located in the operation table, thereby facilitating the user's operations of placing the sample cup 2, taking out the sample cup 2, and the like in the operation table.
The microfluidic detection system 1 of the present invention is in particular provided with a weighing station 81 fixed on a support 83 and a carriage 82 capable of moving the sample cup 2. When detecting, the user only needs to place sample cup 2 on weighing platform 81, and weighing platform 81 measures the weight of sample, and buffer drive arrangement 52 adds appropriate amount of buffer in to sample cup 2, and bracket 82 can drive sample cup 2 automatically and remove in order to apply a sample to microfluidic biochip 10, and the application of sample operation is very convenient, labour saving and time saving, and user's use experience is better. More importantly, the weighing platform 81 is fixed and does not move along with the movement of the bracket 82, so that the movement of the bracket 82 does not have any influence on the weighing precision of the weighing platform 81, high-precision measurement of the weight of a sample is ensured, and the accuracy of the detection result of the microfluidic biochip 10 is further improved.
The inventors have realized that when the sample cup 2 is placed on the weighing station 81 for weighing, the carrier 82 should be completely disengaged from, and out of contact with, the sample cup 2 to avoid having an impact on the weighing of the sample. After the weight of the sample has been measured, the carrier 82 needs to have a holding action on the sample cup 2 to bring it together. That is, the holder 82 needs to have two states of releasing the sample cup and holding the sample cup, and can be automatically switched between these two states according to the detection progress. To achieve this, prior to the present application, the design concept commonly adopted by those skilled in the art was to provide a clamping mechanism for the carrier, and to automatically switch the carrier between two states of releasing the sample cup and holding the sample cup by controlling the action of the clamping mechanism. However, the applicant has appreciated that such conventional design concepts are relatively late and suffer from a number of drawbacks. For example, the clamping mechanism increases the structural complexity of the bracket and requires space for switching the motion of the clamping mechanism to avoid interference or collision with other structures, which all results in an increased volume of the microfluidic detection system, which is not suitable for refrigerators with limited space. For another example, the holding of the sample cup, in particular the release of the sample cup, needs to be kept highly consistent with the detection process, i.e. when the weighing station needs to measure the weight of the sample, it must be ensured that the clamping mechanism is in a state of releasing the sample cup; the clamping mechanism can clamp the sample cup only after the weighing platform finishes measuring the weight of the sample, the time control precision requirement for the state switching of the clamping mechanism is very high, and if the state switching of the clamping mechanism is slightly deviated or error accumulation occurs, the whole detection flow is easily disturbed, so that a correct detection result is not obtained.
Therefore, the inventor tries to break through the traditional design thought and designs a brand new bracket structure. In some embodiments, the bracket 82 is disposed above the weigh table 81 and includes an annular frame 821 that fits over the exterior of the sample cup 2. The carriage 82 is configured to controllably or operatively move in an up-and-down direction and, upon upward movement, to hold the sample cup 2 up with the annular frame 821 such that the sample cup 2 leaves the weighing station 81, supports the sample cup 2 on the weighing station 81 during downward movement to a lowermost position, and urges the sample cup 2 out of engagement with the annular frame 821 with the abutment between the sample cup 2 and the weighing station 81.
That is, as the carriage 82 moves upward, the annular frame 821 can naturally hold the sample cup 2 off the weighing table 81; when the bracket 82 moves downward to a certain position, the sample cup 2 is supported on the weighing platform 81, and the abutment action between the sample cup 2 and the weighing platform 81 is utilized to promote the sample cup 2 to be separated from the annular frame 821 during the process that the bracket 82 continues to move downward to the lowest position, so that the bracket 82 does not have any influence on the weight detection of the sample. It can be seen that the bracket 82 of the present invention completes the natural switching between the lifting and releasing of the sample cup 2 during the lifting process, and no control program for lifting or releasing is required to be designed, so that the structure of the bracket 82 is very simple, and the control logic of the bracket 82 is also very simple.
The present invention also provides a refrigerator, and fig. 7 is a schematic structural view of a refrigerator according to an embodiment of the present invention. The refrigerator 100 of the present invention includes the microfluidic detection system 1 according to any of the above embodiments, so as to integrate the microfluidic detection system 1 on the refrigerator 100. The refrigerator 100 has a high frequency of use in daily life, and the refrigerator 100 is mainly used for storing food, and when the microfluidic detection system 1 is integrated on the refrigerator 100, a user can conveniently perform a detection operation of a food sample using the microfluidic detection system 1.
According to the invention, the microfluidic detection system 1 is integrated on the refrigerator 100, so that the storage function of the refrigerator 100 is fully utilized, the detection process is more convenient, the microfluidic detection system 1 and the refrigerator 100 are convenient to carry out linkage control, the intelligent degree is higher, and the requirements of smart families are met.
Further, the refrigerator 100 further includes a case 200 and a door 300, wherein a storage space is defined in the case 200, and the door 300 is connected to the case 200 and is used to open and/or close the storage space. The microfluidic detection system 1 is preferably arranged on the door 300, so that the operation is convenient, the original storage space in the refrigerator 200 is not occupied, and the storage capacity of the refrigerator 100 is not affected.
The refrigerator 100 of the present application is a refrigerator in a broad sense, which includes not only a refrigerator in a so-called narrow sense, but also a storage device having a refrigerating, freezing or other storage function, for example, a refrigerator, a freezer, etc.
By now it should be appreciated by those skilled in the art that while a number of exemplary embodiments of the invention have been shown and described herein in detail, many other variations or modifications of the invention consistent with the principles of the invention may be directly ascertained or inferred from the present disclosure without departing from the spirit and scope of the invention. Accordingly, the scope of the present invention should be understood and deemed to cover all such other variations or modifications.
Claims (12)
1. A microfluidic detection system for a refrigerator, comprising:
the microfluidic biochip is provided with a sample inlet, an air suction port formed at the end part of the microfluidic biochip and a detection pool formed in the microfluidic biochip, wherein the sample inlet, the detection pool and the air suction port are sequentially communicated through a micro-channel;
an elastic air bag configured to be in sealing contact with an end portion of the microfluidic biochip where the air inlet is formed, an internal space of the elastic air bag communicating with the air inlet;
a sample liquid driving device configured to controllably squeeze and release the elastic air bag so as to promote the sample liquid in contact with the sample inlet to enter the micro flow channel and flow to the detection pool through the micro flow channel in the process of recovering deformation of the elastic air bag; and
and the detection mechanism is used for detecting the detection pool so as to obtain preset detection parameters of the sample liquid.
2. The microfluidic detection system according to claim 1, wherein,
the elastic air bag is hermetically sleeved outside the end part of the microfluidic biochip, wherein the air suction port is formed in the end part.
3. The microfluidic detection system according to claim 2, wherein,
the elastic air bag is provided with a spherical air bag part and a connecting end used for being connected with the microfluidic biochip; and is also provided with
The sample liquid driving device is configured to apply opposing pressing forces to the spherical balloon portion from opposite directions to cause elastic deformation of the spherical balloon portion.
4. The microfluidic detection system according to claim 3, wherein,
the sample inlet is formed at the bottom port of the microfluidic biochip, the air suction port is formed at the top port of the microfluidic biochip, and the elastic air bag is connected above the microfluidic biochip and is hermetically sleeved at the outer side of the top port; and is also provided with
The sample liquid driving device is configured to controllably apply a squeezing force parallel to a horizontal plane to the spherical air bag portion.
5. A microfluidic detection system as claimed in claim 3 wherein the sample liquid drive means comprises:
a driving motor for controllably outputting a driving force;
the screw is connected with the output shaft of the driving motor and is used for rotating under the drive of the driving motor; the screw is provided with a forward thread section and a reverse thread section, and the forward thread section and the reverse thread section are respectively provided with forward threads and reverse threads with opposite directions; and
the two sliding blocks are sleeved on the screw rod and are respectively in threaded connection with the forward thread section and the reverse thread section so as to move towards or away from each other when the screw rod rotates; and is also provided with
The two sliding blocks are respectively positioned on two opposite sides of the elastic air bag.
6. The microfluidic detection system of claim 1, further comprising:
the mounting mechanism is provided with a mounting groove for plugging the microfluidic biochip and a cavity for accommodating the elastic air bag, and the notch of the mounting groove and the opening of the cavity face the same direction; and is also provided with
The microfluidic biochip and the elastic air bag are integrally arranged in the mounting mechanism through the notch of the mounting groove and the opening of the cavity, so that the microfluidic biochip is inserted into the mounting groove, the elastic air bag is accommodated in the cavity, and the sample inlet of the microfluidic biochip is positioned outside the mounting groove.
7. The microfluidic detection system according to claim 6, wherein,
the sample inlet is formed at the bottom port of the microfluidic biochip, the air suction port is formed at the top port of the microfluidic biochip, and the elastic air bag is connected above the microfluidic biochip and is hermetically sleeved at the outer side of the top port; and is also provided with
The mounting groove extends vertically, the cavity is connected above the mounting groove, and the whole formed by the microfluidic biochip and the elastic air bag is configured to be mounted to the mounting mechanism along a direction parallel to a horizontal plane.
8. The microfluidic detection system according to claim 7, wherein,
the size of the mounting groove is smaller than that of the cavity, so that a step part is formed at the boundary of the mounting groove and the cavity; and is also provided with
The size of the top port of the microfluidic biochip in the thickness direction of the microfluidic biochip is larger than the thickness of the microfluidic biochip, and the bottom of the top port is abutted to the step part.
9. The microfluidic detection system according to claim 6, wherein,
the mounting mechanism also has at least one gripping member disposed within the mounting slot, the gripping member configured to grip the microfluidic biochip after the microfluidic biochip is inserted into the mounting slot.
10. The microfluidic detection system according to claim 9, wherein,
the clamping piece comprises two clamping jaws which are symmetrical and are arranged at intervals, and the two clamping jaws are configured to apply opposite elastic acting forces to two opposite side surfaces of the microfluidic biochip respectively after the microfluidic biochip is mounted to the mounting groove.
11. The microfluidic detection system according to claim 1, wherein,
the microfluidic biochip is formed by adopting an injection molding process; and/or
The elastic air bag is formed by silica gel or PE blow molding.
12. A refrigerator comprising a microfluidic detection system according to any one of claims 1-10.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111414287.9A CN116159607A (en) | 2021-11-25 | 2021-11-25 | Microfluidic detection system for refrigerator and refrigerator |
| PCT/CN2022/126153 WO2023093382A1 (en) | 2021-11-25 | 2022-10-19 | Microfluidic detection system for refrigerator, and refrigerator |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111414287.9A CN116159607A (en) | 2021-11-25 | 2021-11-25 | Microfluidic detection system for refrigerator and refrigerator |
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| Publication Number | Publication Date |
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| CN116159607A true CN116159607A (en) | 2023-05-26 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202111414287.9A Pending CN116159607A (en) | 2021-11-25 | 2021-11-25 | Microfluidic detection system for refrigerator and refrigerator |
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| Country | Link |
|---|---|
| CN (1) | CN116159607A (en) |
| WO (1) | WO2023093382A1 (en) |
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| CN205731290U (en) * | 2015-12-23 | 2016-11-30 | 杭州霆科生物科技有限公司 | A kind of food safety detection micro-fluidic chip of pre-stored reaction reagent |
| CN214041434U (en) * | 2020-09-27 | 2021-08-24 | 青岛海尔电冰箱有限公司 | Micro-fluidic detection system for refrigerator and refrigerator |
| CN113306814A (en) * | 2021-05-18 | 2021-08-27 | 广州缘润科电商有限公司 | Automatic filling device of laundry detergent |
| WO2021218399A1 (en) * | 2020-04-27 | 2021-11-04 | 京东方科技集团股份有限公司 | Microfluidic chip and detection system |
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| CN102671729B (en) * | 2012-05-07 | 2014-04-16 | 博奥生物有限公司 | Micro-fluidic chip for multi-index biochemical detection |
| CN204514801U (en) * | 2015-04-01 | 2015-07-29 | 杭州霆科生物科技有限公司 | A kind of throwing type micro-fluidic chip for residues of pesticides Site Detection |
| US20160310948A1 (en) * | 2015-04-24 | 2016-10-27 | Mesa Biotech, Inc. | Fluidic Test Cassette |
| CN214039171U (en) * | 2020-09-27 | 2021-08-24 | 青岛海尔电冰箱有限公司 | Micro-fluidic detection system for refrigerator and refrigerator |
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2021
- 2021-11-25 CN CN202111414287.9A patent/CN116159607A/en active Pending
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- 2022-10-19 WO PCT/CN2022/126153 patent/WO2023093382A1/en unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN205731290U (en) * | 2015-12-23 | 2016-11-30 | 杭州霆科生物科技有限公司 | A kind of food safety detection micro-fluidic chip of pre-stored reaction reagent |
| WO2021218399A1 (en) * | 2020-04-27 | 2021-11-04 | 京东方科技集团股份有限公司 | Microfluidic chip and detection system |
| CN214041434U (en) * | 2020-09-27 | 2021-08-24 | 青岛海尔电冰箱有限公司 | Micro-fluidic detection system for refrigerator and refrigerator |
| CN113306814A (en) * | 2021-05-18 | 2021-08-27 | 广州缘润科电商有限公司 | Automatic filling device of laundry detergent |
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| WO2023093382A1 (en) | 2023-06-01 |
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