CN214039111U

CN214039111U - Refrigerator with a door

Info

Publication number: CN214039111U
Application number: CN202022147449.4U
Authority: CN
Inventors: 朱小兵; 费斌; 孙永升; 刘浩泉
Original assignee: Qingdao Haier Refrigerator Co Ltd; Haier Smart Home Co Ltd
Current assignee: Qingdao Haier Refrigerator Co Ltd; Haier Smart Home Co Ltd
Priority date: 2020-09-27
Filing date: 2020-09-27
Publication date: 2021-08-24
Anticipated expiration: 2030-09-27

Abstract

The utility model relates to a refrigerator, it is including being used for carrying out qualitative or quantitative detection's micro-fluidic detecting system to the detection parameter of predetermineeing of sample liquid, and micro-fluidic detecting system includes: the microfluidic biochip is provided with a sample inlet, a communication port and a detection pool formed inside the microfluidic biochip, and the sample inlet, the detection pool and the communication port are sequentially communicated through a micro-channel; the chip mounting mechanism is used for mounting the microfluidic biochip; the sample liquid driving device is hermetically communicated with the communication port so as to promote the sample liquid contacted with the sample injection port to flow into the micro-channel and flow to the detection pool through the micro-channel; and the detection mechanism is used for detecting the detection pool so as to obtain the preset detection parameters of the sample liquid. Therefore, the sample introduction and detection operation can be smoothly executed, and the accuracy of the detection result can be ensured through the precise control of the sample introduction. Meanwhile, the structure of the micro-fluidic detection system is simplified, and the situation that the micro-fluidic detection system occupies too much space on a refrigerator is avoided.

Description

Refrigerator with a door

Technical Field

The utility model relates to a cold-stored freezing technique especially relates to a refrigerator.

Background

With the improvement of living standard of people, pesticide residues, viruses, nutrient elements or other aspects of edible food materials are generally required to be detected in daily life so as to qualitatively or quantitatively acquire the conditions of the food materials. For example, due to the abuse problem of pesticides, fruits, vegetables and agricultural and sideline products purchased daily by people may have the problem of excessive pesticide residue content, and if the problem of excessive pesticide residue content of the foods cannot be found in time, the foods can cause great harm after being taken by human bodies. As another example, breast feeding advocated at present is the best for infants only when breast milk has normal nutritional value, but in cases of lactating mothers suffering from illness, taking medicine, surgery or other conditions, the nutritional content of milk secreted by the mothers may be reduced and viruses may be produced, thereby affecting the growth and health of the infants.

However, the existing detection system is generally independent, occupies space, is inconvenient to store, and can be forgotten to use after the detection device is stored, or is troublesome and cannot be taken out for use. For this reason, there is a solution in the prior art to integrate a detection system for pesticide residue detection on a refrigerator. The existing pesticide residue detection system integrated on the refrigerator detects gas volatilized by food materials or condensed water flowing down from the food materials, a gas collection device or a liquid collection device is required to be arranged, so that the structure is very complex, the occupied space is large, the normal storage space of a user is influenced, the detection accuracy is very low, and the use experience of the user is influenced to a great extent.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to overcome at least one defect of prior art, provide a refrigerator of the integrated micro-fluidic detecting system that has simple structure.

A further object of the present invention is to improve the operational convenience of the user in replacing microfluidic biochips.

Another further object of the present invention is to attenuate the vibration of the microfluidic detection system, reduce its operating noise, and improve its heat dissipation efficiency.

In order to achieve the above object, the utility model provides a refrigerator, including being used for carrying out qualitative or quantitative detection's micro-fluidic detecting system to the detection parameter of predetermineeing of sample liquid, micro-fluidic detecting system includes:

the microfluidic biochip is provided with a sample inlet, a communication port and a detection pool formed inside the microfluidic biochip, wherein the sample inlet, the detection pool and the communication port are sequentially communicated through a micro-channel;

the chip mounting mechanism is used for mounting the microfluidic biochip;

a sample liquid driving device which is hermetically communicated with the communication port so as to cause the sample liquid contacted with the sample injection port to flow into the micro-channel and flow to the detection cell through the micro-channel; and

and the detection mechanism is used for detecting the detection cell so as to obtain the preset detection parameters of the sample liquid.

Optionally, the sample liquid driving device forms a fluid-tight connection with the communication port through a sealing and butting mechanism; and is

And the connecting port of the microfluidic biochip is fixedly provided with an inserting needle which protrudes outwards and extends, the internal flow channel of the inserting needle is hermetically communicated with the connecting port, the inserting needle is inserted into the sealing and butting mechanism and forms fluid sealing connection with the sealing and butting mechanism, and the sealing and butting mechanism is in fluid sealing connection with the sample liquid driving device, so that the sample liquid driving device is hermetically communicated with the connecting port.

Optionally, an end surface of the extended tip of the insertion needle is a continuous and smooth hemispherical surface, and a needle hole of the insertion needle for fluid communication with the seal docking mechanism is formed on a circumferential side surface of a section of the insertion needle inside the seal docking mechanism.

Optionally, the microfluidic detection system further comprises:

and the chip withdrawing mechanism is used for operably releasing the supporting function of the chip mounting mechanism on the microfluidic biochip so as to release the microfluidic biochip.

Optionally, the chip mounting mechanism comprises two elastic clamping jaws arranged oppositely, so as to apply an opposite acting force to the microfluidic biochip between the two elastic clamping jaws, so that the microfluidic biochip is clamped between the two elastic clamping jaws; and is

The chip withdrawing mechanism is arranged to apply oppositely acting forces to the two elastic clamping jaws to cause the two elastic clamping jaws to elastically deform in a direction away from each other, so that the clamping action of the two elastic clamping jaws on the microfluidic biochip is released.

Optionally, the microfluidic detection system further comprises:

the sample table is used for placing a sample cup, and the sample cup is used for containing a sample liquid; and is

The sample stage is configured for controlled or operable movement to transport a sample cup placed thereon through the sample stage to a position that allows the sample fluid in the sample cup to contact a sample inlet of the microfluidic biochip.

Optionally, the microfluidic biochip is disposed above the sample stage, and the sample inlet is located at the bottom of the microfluidic biochip; and is

The microfluidic detection system also comprises a lifting mechanism for driving the sample stage to move up and down, so that the sample stage is switched between a detection position allowing sample liquid in a sample cup placed on the sample stage to be in contact with the sample inlet and an initial position which is a preset distance below the detection position.

Optionally, the microfluidic detection system further comprises:

the buffer solution bottle is used for containing buffer solution; and

and the buffer driving device is communicated with the buffer liquid bottle to controllably drive the buffer liquid in the buffer liquid bottle into the sample cup placed on the sample platform, so that the buffer liquid is mixed with the sample in the sample cup to generate a sample liquid.

Optionally, the sample liquid driving device is adjacently disposed at a lateral side of the microfluidic biochip, and includes a suspended driving motor.

Optionally, the microfluidic detection system further comprises:

the sample table is used for placing a sample cup, and the sample cup is used for containing a sample liquid; wherein

The sample stage comprises a supporting table for supporting a sample cup and an oscillator arranged on the supporting table, wherein the oscillator is used for oscillating the sample cup after the sample cup is placed on the supporting table, so that the buffer solution and the sample in the sample cup are fully mixed to generate the sample solution.

Optionally, the microfluidic detection system further comprises:

the chip mounting mechanism, the sample liquid driving device, the detection mechanism and at least one part of the microfluidic biochip are all arranged in the shell; and is

The shell is provided with a structural connecting piece used for being connected with a refrigerator body or a door body of the refrigerator and an electric connecting piece used for forming electric connection between the microfluidic detection system and an electric control device of the refrigerator, so that the microfluidic detection system is allowed to be integrally installed on the refrigerator body or the door body of the refrigerator.

Optionally, the refrigerator further comprises:

a case defining a storage space therein for storing articles; and

the door body is connected with the box body and is used for opening and/or closing the storage space; wherein

The micro-fluidic detection device is arranged on the door body.

The utility model discloses a refrigerator includes micro-fluidic detecting system, and micro-fluidic detecting system including the micro-fluidic biochip that is used for providing detection condition and testing environment, be used for installing micro-fluidic biochip's chip installation mechanism, be used for accurately controlling sample liquid inflow micro-fluidic biochip's sample liquid drive arrangement and be used for carrying out the detection mechanism who detects the operation. The combination of the two aspects of the structure and the function of the four modules not only can smoothly execute the sampling and detection operations, but also can ensure the accuracy of the detection result through the accurate control of the sampling. On the basis, the structure of each module is very simple, the structure of the microfluidic detection system is simplified, and the situation that the microfluidic detection system occupies too much space on a refrigerator is avoided.

Furthermore, the microfluidic detection system also comprises a chip withdrawing mechanism, and a user can release the supporting function of the chip mounting mechanism and the microfluidic biochip by operating the chip withdrawing mechanism, so that the microfluidic biochip is released, the user can easily take out the microfluidic biochip or the microfluidic biochip can fall under the action of the gravity of the user, the operation process of the user is simplified, and the operation convenience of replacing the microfluidic biochip by the user is improved.

Furthermore, the sample liquid driving device is provided with a driving motor which is arranged in a suspended mode and is not in contact with other structures, and vibration generated when the driving motor operates is prevented from being transmitted to the microfluidic biochip or other structures, so that vibration of the whole microfluidic detection system is weakened, and operation noise of the microfluidic detection system is reduced. And because the driving motor has higher use frequency and larger heat productivity, the suspended arrangement of the driving motor also increases the space around the driving motor, thereby being beneficial to heat dissipation.

The above and other objects, advantages and features of the present invention will become more apparent to those skilled in the art from the following detailed description of specific embodiments thereof, taken in conjunction with the accompanying drawings.

Drawings

Some specific embodiments of the present invention will be described in detail hereinafter, by way of illustration and not by way of limitation, with reference to the accompanying drawings. The same reference numbers in the drawings identify the same or similar elements or components. Those skilled in the art will appreciate that the drawings are not necessarily drawn to scale. In the drawings:

fig. 1 is a schematic structural view of a refrigerator according to an embodiment of the present invention;

fig. 2 is a schematic block diagram of a microfluidic detection system according to one embodiment of the present invention;

fig. 3 is a schematic exploded view of a microfluidic detection system according to an embodiment of the present invention;

fig. 4 is a schematic structural view of the internal structure of a microfluidic detection system according to an embodiment of the present invention;

fig. 5 is a schematic exploded view of the internal structure of a microfluidic detection system according to an embodiment of the present invention;

fig. 6 is a schematic cross-sectional view of a microfluidic biochip according to one embodiment of the present invention;

fig. 7 is a schematic cross-sectional view of a sample liquid driving device and a microfluidic biochip and their interface structure according to an embodiment of the present invention;

fig. 8 is a schematic cross-sectional exploded view of a sealed docking mechanism and microfluidic biochip according to another embodiment of the present invention;

fig. 9 is a schematic enlarged view of a portion a in fig. 8;

FIG. 10 is a schematic block diagram of a microfluidic biochip, chip mounting mechanism, and chip ejection mechanism according to one embodiment of the present invention;

fig. 11 is a schematic structural view of a lifting mechanism and a sample stage in a disassembled state according to an embodiment of the present invention;

fig. 12 is a schematic exploded view of a door body according to an embodiment of the present invention.

Detailed Description

The utility model provides a refrigerator. Fig. 1 is a schematic structural view of a refrigerator according to an embodiment of the present invention. Referring to fig. 1, a refrigerator 100 according to the present invention includes a cabinet 200 and a door 300. The cabinet 200 defines a storage space for storing articles therein, and the door 300 is connected to the cabinet 200 and opens and/or closes the storage space thereof.

In particular, the refrigerator 100 further comprises a microfluidic detection system 1, wherein the microfluidic detection system 1 is configured to perform qualitative or quantitative detection on a preset detection parameter of the sample liquid, and the preset detection parameter may be, for example, a pesticide residue parameter indicating whether the pesticide residue is out of standard and/or a specific value of the pesticide residue, a nutrient parameter indicating whether a nutrient element is up to standard and/or a specific content of the nutrient element, a specific substance parameter indicating whether a specific harmful substance (e.g., a specific virus) is out of standard and/or a specific content, and the like.

Fig. 2 is a schematic structure diagram of a microfluidic detection system according to an embodiment of the present invention, fig. 3 is a schematic structure exploded view of a microfluidic detection system according to an embodiment of the present invention, fig. 4 is a schematic structure diagram of an internal structure of a microfluidic detection system according to an embodiment of the present invention, and fig. 5 is a schematic structure exploded view of an internal structure of a microfluidic detection system according to an embodiment of the present invention. For ease of understanding, a sample cup 2 is also shown in fig. 1-5.

Referring to fig. 2 to 5, the microfluidic detection system 1 may include a microfluidic biochip 10, a chip mounting mechanism 51, a sample liquid driving device 40, and a detection mechanism 20. It will be appreciated by those skilled in the art that the specific selection of the microfluidic biochip 10 and detection mechanism 20 used in the microfluidic detection system may vary when the predetermined detection parameters for detection are different. For example, when the microfluidic detection system is used for pesticide residue detection, the microfluidic biochip 10 can be a microfluidic pesticide residue detection chip capable of providing detection conditions for pesticide residue, and the detection mechanism 20 can be a pesticide residue detection mechanism capable of detecting pesticide residue parameters of pesticide residue.

Fig. 6 is a schematic cross-sectional view of a microfluidic biochip according to an embodiment of the present invention, the microfluidic biochip 10 has a sample inlet 111, a communication port 112, and a detection cell 121 formed therein, and the sample inlet 111, the detection cell 121, and the communication port 112 are sequentially communicated through a microchannel 14, thereby allowing a sample liquid in contact with the sample inlet 111 to flow into the microchannel 14 and flow into the detection cell 121 through the microchannel 14. The micro flow channel 14 of the present invention means a micro flow channel or a capillary flow channel having a flow area within a predetermined size range, so that it has a suitable capacity of holding liquid therein. The sample inlet 111 and the communication port 112 may be formed at the end of the microfluidic biochip 10. Further, the sample inlet 111 and the communication port 112 are preferably formed at different ends of the microfluidic biochip 10.

The chip mounting mechanism 51 is used to mount the microfluidic biochip 10 to provide a support for the microfluidic biochip 10.

The sample liquid driving device 40 is in sealed communication with the communication port 112 to cause the sample liquid in contact with the sample inlet 111 to flow into the microchannel 14 and to the detection cell 121 through the microchannel 14, thereby precisely controlling the amount and flow rate of the sample liquid entering the detection cell 121.

The detection mechanism 20 is used for detecting the detection cell 121 to obtain preset detection parameters of the sample liquid. Specifically, the detection cell 121 may be provided with a detection reagent in advance, or the detection reagent may be manually or automatically added to the detection cell 121, so that the detection mechanism 20 detects the detection cell 121 after the sample solution in the detection cell 121 reacts with the detection reagent therein.

The utility model discloses a refrigerator 100 includes micro-fluidic detecting system 1, and micro-fluidic detecting system 1 is including the micro-fluidic biochip 10 that is used for providing detection condition and testing environment, be used for installing micro-fluidic biochip 10 chip installation mechanism 51, be used for accurately controlling sample liquid inflow micro-fluidic biochip 10's sample liquid drive arrangement 40 and be used for carrying out detection operation's detection mechanism 20. The combination of the two aspects of the structure and the function of the four modules not only can smoothly execute the sampling and detection operations, but also can ensure the accuracy of the detection result through the accurate control of the sampling. On this basis, the structure of each module is very simple, so that the structure of the microfluidic detection system 1 is simplified, and the situation that the microfluidic detection system occupies too much space on the refrigerator 100 is avoided.

In a specific embodiment, when the detecting mechanism 20 is a pesticide residue detecting mechanism for detecting pesticide residue parameters of pesticide residue, an enzyme inhibition rate method can be used to perform rapid qualitative detection on whether pesticide residue in the sample liquid exceeds standard. At this time, the microfluidic biochip 10 further includes a reaction cell 122 formed therein, and the reaction cell 122 is located on a main channel formed by sequentially communicating the sample inlet 111, the detection cell 121, and the communication port 112, and is communicated between the sample inlet 111 and the detection cell 121, so that the sample solution firstly reacts with the reaction reagent in the reaction cell 122 and then flows into the detection cell 121. The reaction cell 122 is communicated with the sample inlet 111, and the reaction cell 122 is communicated with the detection cell 121 through the microchannel 14. The reaction reagent and the detection reagent for pesticide residue detection can be an enzyme reagent and a color-developing agent respectively. The reaction cell 122 is used for allowing the sample liquid to react with the enzyme reagent therein, and the sample liquid after reacting with the enzyme reagent flows into the detection cell 121 to react with the color developing agent in the detection cell 121. The detection mechanism 20 may be selected as a photoelectric detection mechanism, and may include a light source 21 and a photosensitive element 22 respectively disposed at two opposite sides of the microfluidic biochip 10 and facing the detection cell 121, light emitted from the light source 21 is irradiated to the detection cell 121, and light passing through the detection cell 121 is guided to the photosensitive element 22, so that it is beneficial to determine absorbance change in the detection cell 121 through a light intensity signal received by the photosensitive element 22, and further calculate the pesticide residue inhibition rate. Further, the detecting mechanism 20 further includes a heating plate 24 for supplying heat to the detecting cell 121 and a temperature controller 25 for controlling the heating plate 24 to have a constant heating power, so that the sample liquid and the detecting reagent in the detecting cell 121 can be reacted sufficiently and quickly.

In some embodiments, the sample liquid driving device 40 may be disposed adjacent to the microfluidic biochip 10 in the lateral direction, so as to ensure the compactness of the structural layout between the microfluidic biochip 10 and the sample liquid driving device 40, and to enable the liquid to flow or drop down along the microfluidic biochip 10 when the liquid in the microfluidic biochip 10 leaks or is discharged outside, without contacting the sample liquid driving device 40, thereby avoiding the adverse effect on the sample liquid driving device 40.

Further, the sample liquid driving device 40 may include a driving motor 41 disposed in an air-suspension manner. That is, the driving motor 41 is connected to the supporting structure only through the top portion thereof, and is not in contact with other structures, so that the vibration generated during the operation of the driving motor 41 is prevented from being transmitted to the microfluidic biochip 10 or other structures, which not only prevents the adverse effect on the stability or performance of the microfluidic biochip 10 or other structures, but also weakens the vibration of the entire microfluidic detection system 1 and reduces the operation noise thereof. In addition, the driving motor 41 has higher use frequency and larger heat productivity, so that the suspended arrangement of the driving motor 41 also increases the space around the driving motor, which is beneficial to heat dissipation.

Specifically, the sample liquid driving device 40 may form a negative pressure in the main channel by pumping air outwards, so that the sample liquid contacting with the sample inlet 111 enters the main channel under the action of the negative pressure. Fig. 7 is a schematic cross-sectional view of a sample liquid driving device and a microfluidic biochip and their connection structure according to an embodiment of the present invention. In some embodiments, the sample fluid drive device 40 may be a micro syringe pump and further include a vertically extending syringe 42, a lead screw 43, a slider 44, and a piston 45. The syringe 42 is fixed to a holder 87, and the top of the syringe 42 is in sealed communication with the communication port 112 on the top of the microfluidic biochip 10 through the connecting line 46. The lead screw 43 extends vertically and is connected to the driving motor 41 to be rotated by the driving motor 41. The slider 44 is inserted into the screw rod 43 and is connected with the screw rod 43 by screw threads so as to move up and down along the screw rod 43 along with the rotation of the screw rod 43. The piston 45 is disposed inside the injector 42 and fixedly connected to the slider 44 to move in the vertical direction under the driving of the slider 44, so that when the piston moves in the vertical direction, a negative pressure is generated in the main channel to force the sample liquid contacting the sample inlet 111 to flow into the microchannel and flow into the detection cell 121 through the microchannel, and when the piston moves in the vertical direction, the sample liquid in the main channel is forced to flow toward the sample inlet 111.

The sample liquid driving device 40 may further include a position sensor, which is used to cooperate with the driving motor 41 to control the displacement of the piston 45 in the upward translation and/or the downward translation, so as to achieve precise control of sample injection. Meanwhile, the displacement of the piston 45 in upward translation and downward translation can be monitored in real time, so that fine pushing and sucking operations can be performed, the sample liquid entering the main channel is subjected to liquid pushing and liquid sucking actions in the opposite directions on the premise that the sample liquid cannot flow out through the communication port 112, the sample liquid in the detection cell 121 and detection reagents in the detection cell are enabled to be mixed more uniformly or react more fully, and the accuracy of detection results is improved.

In some embodiments, the sample fluid drive device 40 forms a fluid tight connection with the communication port 112 via the seal interface mechanism 90. Referring to fig. 7, the seal interfacing mechanism 90 may include a seal connection 91 and a resilient press member 92. The sealing connector 91 is connected between the microfluidic biochip 10 and the sample liquid driving device 40, and a connection channel penetrating the sealing connector 91 is formed therein. The elastic pressing member 92 is used for applying an elastic force to the sealing connector 91 so that the sealing connector 91 is simultaneously in sealing abutment with the sample liquid driving device 40 and the microfluidic biochip 10, thereby allowing the communication ports 112 of the sample liquid driving device 40 and the microfluidic biochip 10 to be in sealing communication through the connection channels inside the sealing connector 91. Therefore, the elastic acting force can be applied to the sealing connector 91 through the elastic pressing member 92, so that the sealing connector 91 is always kept in a state of being tightly and hermetically butted with the sample liquid driving device 40 and the microfluidic biochip 10, the problems of looseness, fracture and the like caused by long-time use due to the adoption of other butting mechanisms are avoided, the long-term and reliable fluid sealing communication relation between the sample liquid driving device 40 and the communication port 112 of the microfluidic biochip 10 is ensured, and the sealing effect between the two is improved.

In some embodiments, the sample fluid drive device 40 communicates with the communication port 112 through the connecting line 46. The communication port 112 may be formed on the top of the microfluidic biochip 10, and the sample liquid driving device 40 may be adjacently disposed on the lateral side of the microfluidic biochip 10 to avoid the sample liquid driving device 40 from being adversely affected by the leakage liquid that may be generated by the microfluidic biochip 10. The connecting line 46 may communicate with the top of the sample liquid driving device 40 to bridge between the sample liquid driving device 40 and the microfluidic biochip 10.

Further, the sealing connector 91 may comprise a first connection block 912 for directly interfacing with the microfluidic biochip 10 and a second connection block 913 arranged at a side of the first connection block 912 facing away from the microfluidic biochip 10. The first connection block 912 and the second connection block 913, and the second connection block 913 and the connection pipe 46 are connected in a plugging manner to form a sealing connection.

In some embodiments, the elastic pressing member 92 may be a spring, one end of the spring abuts against a fixedly disposed end plate 513, and the other end abuts against the sealing connector 91, and the end plate 513 and the microfluidic biochip 10 are respectively located at two opposite sides of the sealing connector 91. In particular, in the mounted state of the microfluidic biochip 10, the springs are in a compressed state, thereby generating an elastic force for urging the sealing connection 91 to have a tendency to move towards the microfluidic biochip 10. The number of the elastic pressing members 92 can be two or more than two, so as to increase the magnitude of the elastic acting force acting on the microfluidic biochip 10, make the elastic acting force applied on the microfluidic biochip 10 more balanced, avoid the inclination, and further improve the effect of sealing connection.

Further, the sealing and docking mechanism 90 further includes a guide rod 93, and the spring is sleeved on the guide rod 93 to prevent the spring from displacing. One end of the guide rod 93 is fixedly connected with the sealing connector 91, and the other end of the guide rod is in contact with a hall switch 94 after the microfluidic biochip 10 is in sealing butt joint with the sealing connector 91, so that the hall switch 94 is prompted to generate a trigger signal for indicating that the microfluidic biochip 10 is installed in place, a user is prompted, structural damage caused by excessive installation of the microfluidic biochip 10 is avoided, and the use experience of the user is improved.

In order to improve the sealing performance between the sealing and docking mechanism 90 and the microfluidic biochip 10, the present application also provides another embodiment of the sealing and docking mechanism 90 and the microfluidic biochip 10. Fig. 8 is a schematic cross-sectional exploded view of a hermetic docking mechanism and a microfluidic biochip according to another embodiment of the present invention, and fig. 9 is a schematic enlarged view of a portion a in fig. 8. In fig. 8, the elastic pressing member and the guide rod of the sealing and docking mechanism are omitted. In other embodiments, the connection port 112 of the microfluidic biochip 10 of the present invention is further fixedly connected with the insertion needle 15 protruding and extending outward, the internal channel 151 of the insertion needle 15 is in sealed connection with the connection port 112, and the insertion needle 15 is inserted into the sealing and docking mechanism 90 and forms a fluid-tight connection with the sealing and docking mechanism 90. That is, the sealing and docking mechanism 90 is simultaneously connected with the sample liquid driving device 40 and the insertion needle 15 in a fluid-tight manner, so that a good sealing and communication relationship between the sample liquid driving device 40 and the communication port 112 of the microfluidic biochip 10 is realized.

Specifically, the connector pin 15 can be inserted into the sealing connector 91 of the sealing interface 90. The seal connection 91 in the embodiment shown in fig. 8 and 9 has a slightly different structure than the seal connection 91 in the embodiment shown in fig. 7. The bottom of the first connection block 912 of the sealing connection 91 in the embodiment shown in fig. 8 and 9 may be provided with a through hole 9121 for inserting the plug pin 15, and the through hole 9121 and the plug pin 15 may be in sealing fit by abutting contact or pressing contact. The insertion needle 15 may be provided with a needle hole 152 for fluidly connecting the internal flow channel 151 thereof with the inside of the sealing and docking mechanism 90, and the needle hole 152 is provided on a section of the insertion needle 15 located inside the sealing and docking mechanism 90, that is, the needle hole 152 of the insertion needle 15 is located inside the sealing and docking mechanism 90, so that a smooth and good fluid communication relationship between the two is ensured, the sealing performance between the two is improved to a great extent, and the problems of air leakage, liquid leakage and the like at the joint between the two are avoided.

Further, in order to avoid the damage of the sealing and docking mechanism 90 after the plugging pin 15 is frequently plugged and unplugged, the structural strength of the sealing and docking mechanism 90 may be improved, however, the requirement on the material of the sealing and docking mechanism 90 is high, and even if the material with high structural strength is adopted, the sealing and docking mechanism 90 may still be structurally damaged after the plugging pin 15 is plugged and unplugged for a limited number of times. For this reason, the applicant of the present application, from another point of view, improves the structure of the insert pin 15. Referring to fig. 9, the end surface 153 of the extended end of the connector pin 15 is a continuous and smooth hemispherical surface, and the needle hole 152 of the connector pin 15 for fluid communication with the sealing interface 90 is formed in the circumferential side 154 of the section of the connector pin 15 inside the sealing interface 90. Therefore, when the microfluidic biochip 10 provided with the insertion needle 15 is in sealed butt joint with the sealed butt joint mechanism 90, the contact surface between the insertion needle 15 and the sealed butt joint mechanism 90 is a smooth spherical surface, so that friction between the insertion needle 15 and the sealed butt joint mechanism 90 is reduced, the sealed butt joint mechanism 90 cannot be scratched or punctured, the sealed butt joint mechanism 90 is ensured to keep a good sealed butt joint function for a long time, the service life of the microfluidic detection system 1 is prolonged, and meanwhile, the requirement on the structural strength of the sealed butt joint mechanism 90 is reduced.

It should be noted that the extending end of the insertion pin 15 means an end of the insertion pin 15 extending into the sealing and docking mechanism 90. Further, the needle hole 152 may be formed at a circumferential side of a section of the bayonet 15 adjacent to an extended end thereof, whereby a fluid communication relationship between the bayonet 15 and the seal interfacing mechanism 90 may be ensured even if the section of the bayonet 15 inserted into the seal interfacing mechanism 90 is not long.

Further, referring to fig. 8 and 9, the insertion needle 15 is inserted into the microfluidic biochip 10 through the communication port 112, and the start end of the insertion needle 15 extending into the microfluidic biochip 10 is opened so as to communicate with the microchannel 14, thereby communicating with the communication port 112. The mating interface of the insertion needle 15 and the communication port 112 can be sealed by a sealant 16 to enhance the sealing performance between the insertion needle 15 and the microfluidic biochip 10.

In some alternative embodiments, the insertion needle 15 may also be integrally formed with the microfluidic biochip 10.

In some embodiments, the microfluidic detection system 1 further comprises a chip ejection mechanism 52 for operably releasing the support of the microfluidic biochip 10 by the chip mounting mechanism 51 to release the microfluidic biochip 10. Therefore, the user can release the supporting function of the chip mounting mechanism 51 and the microfluidic biochip 10 by operating the chip ejection mechanism 52, so as to release the microfluidic biochip 10, and the user can easily take out the microfluidic biochip 10 or the microfluidic biochip 10 can fall down under the action of gravity of the user, thereby simplifying the operation process of the user and improving the operation convenience of the user for replacing the microfluidic biochip 10.

Further, the chip withdrawing mechanism 52 may be exposed outside the refrigerator 100, so as to facilitate the user to carry out the chip withdrawing operation, and no matter how compact the structural layout of the microfluidic detection system 1 itself and the overall structural layout thereof integrated in the refrigerator are, the detaching operation of the microfluidic biochip 10 is not affected, thereby improving the user experience.

Fig. 10 is a schematic structural view of a microfluidic biochip, a chip mounting mechanism, and a chip ejection mechanism according to an embodiment of the present invention. In some embodiments, the chip mounting mechanism 51 may comprise two elastic clamping jaws 511 oppositely arranged to apply an opposite force to the microfluidic biochip 10 between the two elastic clamping jaws 511, such that the microfluidic biochip 10 is clamped between the two elastic clamping jaws 511. And, the chip withdrawing mechanism 52 is configured to operatively apply opposite forces to the two elastic clamping jaws 511 to cause the two elastic clamping jaws 511 to elastically deform in a direction away from each other, thereby releasing the clamping action of the two elastic clamping jaws 511 on the microfluidic biochip 10.

Specifically, the chip withdrawing mechanism 52 may include a cantilever key 521 suspended at one side of the microfluidic biochip 10 and an abutting block 522 convexly extending from an inner side of the cantilever key 521 toward the microfluidic biochip 10 to a direction gradually approaching the microfluidic biochip 10, and the abutting block 522 is simultaneously abutted against the oppositely disposed inner sides of the two elastic clamping jaws 511, so as to apply an outward acting force to the inner sides of the two elastic clamping jaws 511 through the abutting block 522 when the cantilever key 521 is subjected to an acting force toward the microfluidic biochip 10, thereby elastically deforming the two elastic clamping jaws 511 toward outer side directions away from each other. That is, when the microfluidic biochip 10 needs to be disassembled, the user can release the clamping effect of the two elastic clamping jaws 511 on the microfluidic biochip 10 by pressing the cantilever button 521, so as to release the microfluidic biochip 10, the operation is very simple and convenient, and the chip withdrawing mechanism 52 has a very simple structure and a very smart design.

Two opposite side surfaces of the abutting block, which abut against the inner sides of the two elastic clamping jaws 511 respectively, are inclined oppositely along the direction gradually approaching the microfluidic biochip 10, so that the smoothness of the pressing operation of the cantilever key 521 is ensured, and the phenomena of jamming and the like are avoided. Specifically, the abutting block may be substantially in the shape of an isosceles trapezoid, a lower bottom of the isosceles trapezoid is connected to the cantilever key 521, and two waists of the isosceles trapezoid abut against inner sides of the two elastic clamping jaws 511, respectively.

In some embodiments, the microfluidic detection system 1 further comprises a sample stage 70, the sample stage 70 is used for placing the sample cup 2, and the sample cup 2 is used for containing the sample liquid. And, the sample stage 70 is arranged to be controllably or operatively moved to transport the sample cup 2 placed thereon by the sample stage 70 to a position allowing the sample liquid in the sample cup 2 to contact the sample inlet 111 of the microfluidic biochip 10. Thus, sample application of the microfluidic biochip 10 is achieved. The user only needs to place the sample cup 2 on the sample stage 70, or place the sample cup 2 on the sample stage 70 and then move the sample stage 70 to the position contacting with the sample inlet 111 of the microfluidic biochip 10, so that the sample adding operation is very convenient and fast, and time and labor are saved. In addition, the sample stage 70 is arranged to be movable, so that complex structures such as a sample liquid conveying pump, a conveying pipeline, a sampling needle and the like are omitted, the structure of the microfluidic detection system 1 is very simple, and the situation that too much space of a refrigerator is occupied is avoided.

Further, the microfluidic biochip 10 may be disposed above the sample stage 70, and the sample inlet 111 is located at the bottom of the microfluidic biochip 10 so that the sample inlet 111 contacts the sample liquid in the sample cup 2 placed on the sample stage 70. The microfluidic detection system 1 further includes a lifting mechanism 60 for driving the sample stage 70 to move up and down, so that the sample stage 70 is switched between a detection position allowing the sample liquid in the sample cup 2 placed on the sample stage 70 to contact the sample inlet 111 and an initial position at a preset distance below the detection position. That is, the sample stage 70 can be automatically lifted by the upgrading mechanism 60, so that the operation of the user is further simplified, and the automation degree of the microfluidic detection system is improved.

Fig. 11 is a schematic structural view of the lifting mechanism and the sample stage in a disassembled state according to an embodiment of the present invention. In some embodiments, the lift mechanism 60 may include a lift motor 61, a drive screw 62, and a nut 63. The lift motor 61 is used to output a driving force. The driving screw 62 is disposed in a vertical direction and connected to an output shaft of the elevating motor 61 to be rotated by the elevating motor 61. The nut 63 is arranged on the transmission screw rod 62 in a penetrating way and is in threaded connection with the transmission screw rod 62 so as to move up and down along the transmission screw rod 62 along with the rotation of the transmission screw rod 62. The sample stage 70 is fixedly connected with the nut 63 so as to drive the sample stage 70 to move up and down through the nut 63.

Further, the lifting mechanism 60 further includes a slide rail 64 and a slider 65. The slide rail 64 is arranged beside the transmission screw rod 62 in parallel with the transmission screw rod 62, the slide block 65 is movably arranged on the slide rail 64, and the sample table 70 is fixedly connected with the slide block 65 so as to guide the sample table 70 to move up and down through the matching of the slide rail 64 and the slide block 65. Specifically, the slide block 65 is driven to move synchronously when the sample stage 70 moves in the up-down direction under the action of the driving module, the slide block 65 is limited on the slide rail 64, and the slide rail 64 has guiding and limiting functions on the movement of the slide block 65, so that the sample stage 70 is indirectly guided and limited, the sample stage 70 is prevented from being shifted or stuck in the moving process, and the moving stability of the sample stage 70 is improved. Specifically, the sample stage 70 may include a horizontal connecting plate 74 penetrating the driving screw 62 and fixedly connected to the nut 63, and a vertical connecting plate 75 extending upward perpendicular to the horizontal connecting plate 74, the vertical connecting plate 75 being fixedly connected to the slide block 65.

In some embodiments, the lifting mechanism 60 further comprises a limit switch 66, and the limit switch 66 is disposed adjacent to the upper portion of the transmission screw 62 to cause the lifting motor 61 to stop operating when the sample stage 70 moves upward to touch the limit switch 66. And, the position of the limit switch 66 is set so that the sample stage 70 is in its detection position when the elevating motor 61 stops operating under the trigger of the limit switch 66. The elevating motor 61 is not operated to keep the sample stage 70 at its detecting position. The detection position of the sample table 70 is positioned through the limit switch 66, the positioning is accurate, and the problem that the sample table 70 exceeds the detection position to continuously move to cause the damage of the sample table 70, the microfluidic biochip 10 and other structures can be avoided.

In some embodiments, the sample stage 70 may include a support stage 71 and an oscillator 72. The support stage 71 is for supporting the sample cup 2. Specifically, the supporting platform 71 may be a horizontally disposed supporting plate, and a groove for placing the bottom of the sample cup 2 therein may be disposed on the supporting plate, so as to prevent the sample cup 2 from toppling or shaking during the moving process of the sample platform 70, thereby improving the stability of placing the sample cup 2. The support table 71 is fixedly connected with the horizontal connecting plate 74.

The oscillator 72 is disposed on the supporting platform 71, and is configured to oscillate the sample cup 2 after the sample cup 2 is placed on the supporting platform 71, so that a buffer solution in the sample cup 2 and a sample are sufficiently mixed to generate a sample solution, and a substance to be detected on the sample is sufficiently dissolved in the buffer solution to obtain the sample solution with a suitable concentration. The buffer solution may be pre-set in the sample cup 2 by means of manual addition, or may be automatically transferred to the sample cup 2 by the driving means after the sample cup 2 is placed on the sample stage 70.

In some embodiments, the sample stage 70 further comprises a load cell 73, the load cell 73 being arranged below the support stage 71 for weighing the weight of the sample in the sample cup 2, thereby allowing the buffer drive 30 to deliver a preset amount of buffer matching the weight of the sample to the sample cup 2. Usually, the sample is taken at will by the home user, for example, a small piece of vegetable leaves is torn off at will, and therefore, in order to ensure the accuracy of the measurement result, the amount of the buffer solution input into the sample cup 2 needs to be matched with the amount of the sample, so as to generate the sample solution with proper concentration. The weight of the sample can be automatically and accurately obtained through the weighing sensor 73 arranged below the supporting table 71, so that the buffer solution driving device 30 is automatically controlled to input the matched amount of buffer solution into the sample cup 2, the accuracy of the measuring result is ensured, various problems of inconvenience in use, complex operation, large error and the like caused by manual measurement of the sample by a user are avoided, and the automation degree of the microfluidic detection system and the use experience of the user are further improved.

It should be noted that, in some alternative embodiments, the sample stage 70 may be fixed, and the microfluidic pesticide residue detection chip 10 may be configured to be movable, which can also facilitate the sampling operation.

In some embodiments, the microfluidic detection system 1 further comprises a buffer solution bottle 36 and a buffer solution driving device 30. The buffer solution bottle 36 is used for containing buffer solution. The buffer driving device 30 is communicated with the buffer bottle 36 to controllably drive the buffer in the buffer bottle 36 into the sample cup 2 placed on the sample stage 70, so that the buffer is mixed with the sample in the sample cup 2 to generate the sample liquid. Specifically, the buffer solution bottle 36 is communicated with the buffer solution driving device 30 through the inlet tube 32. The extraction tube 31 of the buffer driving device 30 extends to the sample stage 70. The method mainly aims at that a detected sample is a solid sample, and a buffer solution is needed to dissolve a substance to be detected on the solid sample into the solid sample so as to form a sample solution; alternatively, the sample is a liquid sample, but the concentration is too high, and it is necessary to dilute the sample with a buffer solution to produce a sample solution. For example, in the case of pesticide residue detection, the sample to be detected is usually a solid food residue such as epidermis or leaf, and the sample is placed in a buffer solution, and the pesticide residue on the sample is dissolved in the buffer solution to form a sample solution.

In particular, the buffer drive 30 may be a peristaltic pump, a diaphragm pump, or other suitable type of drive. The peristaltic or membrane pump generates a large vibration in its radial direction when it is operated, and in order to avoid that the vibration is transmitted to the microfluidic biochip 10, the radial outer side of the peristaltic or membrane pump may be provided with an elastic vibration reduction member 35. The elastic damping member 35 may be fitted over the outside of the buffer driving device 30 and supported in the housing 80 by the clamping action of the bracket 87 and the fixing block 89, and the fixing block 89 may be fixed to the support plate 86.

In some embodiments, the microfluidic detection system 1 further comprises a housing 80, and at least a portion of the chip mounting mechanism 51, the sample liquid driving device 40, the detection mechanism 20, and the microfluidic biochip 10 are disposed in the housing 80. The housing 80 is provided with a first structural connection 81 for connection to the cabinet or door of the refrigerator 100 and a first electrical connection 82 for forming an electrical connection between the microfluidic detection system 1 and an electrical control device of the refrigerator 100, so as to allow the microfluidic detection system 1 to be mounted as a whole to the cabinet or door of the refrigerator 100.

Further, the housing 80 is formed with a console 83 opened toward the front side thereof, and the sample stage 70 is at least partially located in the console 83, thereby facilitating the user to perform operations of placing the sample cup 2, taking out the sample cup 2, and the like in the console 83. A water receiving box 88 may be disposed in the operation platform 83 below the sample platform 70 to receive liquid that may drip, so as to avoid contaminating the operation platform 83.

In some embodiments, the microfluidic detection system 1 further comprises a circuit board 53, a display device 56, and a switch button 57, the circuit board 53 being disposed within the housing 80 and electrically connected to the first electrical connector 82 on the housing 80. The electrical components (e.g., the lifting mechanism 60, the buffer driving device 30, the sample liquid driving device 40, the detection mechanism 20, the display device 56, the switch button 57, etc.) of the microfluidic detection system 1 are all directly or indirectly electrically connected to the circuit board 53. The display device 56 is disposed on the front side of the housing 80 and electrically connected to the circuit board 53 for displaying the detection result of the detection mechanism 20. The switch button 57 is disposed on the front side of the housing 80 and electrically connected to the circuit board 53 for activating and/or deactivating the detection function of the microfluidic detection system 1. That is, the user can activate, suspend, or deactivate the detection function of the microfluidic detection system 1 by operating the switch button 57.

In some embodiments, the housing 80 may include a rear case 84 at a rear side and a front panel 85 connected to a front side of the rear case 84. The rear housing 84 and the front panel 85 define a receiving cavity therebetween when assembled. Further, a support plate 86 and a bracket 87 are provided in the housing chamber of the housing 80. The supporting plate 86 is fixedly connected to the rear housing 84, and at least a part of the elevating mechanism 60 (e.g., an immovable part of the elevating mechanism) and the buffer driving unit 30 are fixed to the supporting plate 86. The holder 87 is fixedly attached to the front side of the support plate 86, and both the microfluidic biochip 10 and the sample liquid driving device 40 are directly or indirectly supported on the holder 87. Thus, the elevating mechanism 60, the buffer driving device 30, the microfluidic biochip 10, and the sample liquid driving device 40 can be stably supported by the support plate 86 and the holder 87 in the accommodation chamber formed between the rear case 84 and the front panel 85.

In some embodiments, the lifting mechanism 60 may be disposed at a lateral side of the sample stage 70, the buffer driving device 30 may be disposed at one lateral side of the microfluidic biochip 10 and above the lifting mechanism 60, the sample liquid driving device 40 is disposed at the other lateral side of the microfluidic biochip 10, and the buffer bottle 36 is disposed at a side of the sample liquid driving device 40 facing away from the microfluidic biochip 10. The microfluidic biochip 10, the sample stage 70, the lifting mechanism 60, the buffer driving device 30, the sample liquid driving device 40 and the buffer liquid bottle 36 which are arranged in this way fully utilize the dimensional characteristics of each module in the vertical direction and the transverse direction, so that the arrangement of each module is more compact, and the occupied space is reduced as much as possible. Moreover, the modules are arranged side by side only in the vertical direction and the transverse direction, so that the thickness of the microfluidic detection system 1 in the front and rear directions is reduced as much as possible, and the microfluidic detection system is more suitable for being integrated on a refrigerator.

Further, a partition 861 extending transversely may be disposed between the buffer driving device 30 and the lifting mechanism 60 to prevent the buffer driving device 30 from leaking liquid and dropping on the lifting mechanism 60, which may affect the normal operation of the lifting mechanism 60. The partition 861 may be fixed to the support plate 86.

In some embodiments, the micro-fluidic detection device 1 is disposed on the door 300, so that the operation is convenient, the original storage space in the refrigerator body 200 is not occupied, and the storage capacity of the refrigerator 100 is not affected.

Fig. 12 is a schematic exploded view of a door body according to an embodiment of the present invention. In some embodiments, the hollow window 301 is disposed on the front side of the door 300, and the sample stage 70 of the microfluidic detection system 1 is exposed to the front side of the door 300 through the hollow window 301, so that a user can place a sample cup on the sample stage 70 without opening the door 300, the problem of serious cold leakage caused by opening the door 300 during each detection is avoided, the heat preservation performance of the refrigerator 100 is ensured, and energy consumption is reduced.

Specifically, the door body 300 may include a panel 302 for forming a front portion thereof, a door liner 303 for forming a rear portion thereof, and a foam insulation layer (not shown) disposed between the panel 302 and the door liner 303, and the cutout window 301 is opened on the panel 302. An embedded box 304 is embedded between the panel 302 and the door liner 303 before the foaming heat-insulating layer is formed, and the microfluidic detection system 1 is arranged in the embedded box 304. That is, the pre-embedded box 304 is pre-arranged between the panel 302 and the door liner 303 before the door 300 is foamed, so as to reserve a space for installing the microfluidic detection system 1 between the panel 302 and the door liner 303.

Further, the embedded box 304 is attached to the rear surface of the panel 302, the front side of the embedded box 304 is open and faces the hollow window 301, so that the micro-fluidic detection system 1 is allowed to be installed into the embedded box 304 from front to back through the hollow window 301, and the installation convenience of the micro-fluidic detection system 1 is improved.

Specifically, the embedded box 304 may be provided with a second structure connector 305 connected to the first structure connector 81 in a matching manner and a second electrical connector 306 electrically connected to the first electrical connector 82, and the second electrical connector 306 is electrically connected to the electric control device of the refrigerator 100. Therefore, the micro-fluidic detection system 1 is integrally mounted on the door 300 by arranging corresponding structural connecting pieces and electrical connecting pieces on the embedded box 304 and the shell 80, so that the connection between the whole micro-fluidic detection system 1 and the refrigerator 100 is realized in both structural and circuit aspects. Therefore, the assembly process of the microfluidic detection system 1 is simplified, and the disassembly or the maintenance of the microfluidic detection system 1 is facilitated.

The refrigerator 100 of the present application is a refrigerator in a broad sense, and includes not only a so-called refrigerator in a narrow sense but also a storage device having a refrigerating, freezing or other storage function, for example, a refrigerator, a freezer, and the like.

It should be further understood by those skilled in the art that the terms "upper", "lower", "front", "rear", "top", "bottom", etc. used in the embodiments of the present invention are used as terms for indicating the orientation or the positional relationship with respect to the actual use state of the refrigerator 100, and these terms are only used for the convenience of description and understanding of the technical solution of the present invention, and do not indicate or imply that the device referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be interpreted as limiting the present invention.

Thus, it should be appreciated by those skilled in the art that while a number of exemplary embodiments of the invention have been shown and described in detail herein, many other variations and modifications can be made, consistent with the principles of the invention, which are directly determined or derived from the disclosure herein, without departing from the spirit and scope of the invention. Accordingly, the scope of the present invention should be understood and interpreted to cover all such other variations or modifications.

Claims

1. A refrigerator, characterized in that it comprises a microfluidic detection system for qualitative or quantitative detection of a preset detection parameter of a sample liquid, said microfluidic detection system comprising:

the chip mounting mechanism is used for mounting the microfluidic biochip;

2. The refrigerator according to claim 1,

the sample liquid driving device is in fluid sealing connection with the communication port through a sealing butt joint mechanism; and is

3. The refrigerator according to claim 2,

the end face of the extending tail end of the inserting needle is a continuous and smooth hemispherical surface, and a needle hole of the inserting needle, which is used for being in fluid communication with the sealing and butting mechanism, is formed in the circumferential side face of the section, located in the sealing and butting mechanism, of the inserting needle.

4. The refrigerator of claim 1, wherein the microfluidic detection system further comprises:

5. The refrigerator according to claim 4,

the chip mounting mechanism comprises two elastic clamping jaws which are oppositely arranged so as to apply opposite acting force to the microfluidic biochip between the two elastic clamping jaws, so that the microfluidic biochip is clamped between the two elastic clamping jaws; and is

6. The refrigerator of claim 1, wherein the microfluidic detection system further comprises:

7. The refrigerator according to claim 6,

the microfluidic biochip is arranged above the sample stage, and the sample inlet is positioned at the bottom of the microfluidic biochip; and is

8. The refrigerator of claim 6, wherein the microfluidic detection system further comprises:

the buffer solution bottle is used for containing buffer solution; and

9. The refrigerator according to claim 1,

the sample liquid driving device is adjacently arranged at the lateral side of the microfluidic biochip in the transverse direction and comprises a driving motor arranged in a suspension manner.

10. The refrigerator of claim 1, wherein the microfluidic detection system further comprises:

11. The refrigerator of claim 1, wherein the microfluidic detection system further comprises:

12. The refrigerator according to claim 1, further comprising:

a case defining a storage space therein for storing articles; and

The micro-fluidic detection device is arranged on the door body.