CN114324912A - Biological detection device and refrigerator - Google Patents

Abstract

The invention relates to a biological detection device and a refrigerator, the biological detection device comprises: the chip mounting part is provided with a plurality of fluid interfaces which are communicated with a plurality of detection channels formed in the at least one biological detection chip in a one-to-one correspondence manner; and a driving mechanism disposed on the holder and communicating with each of the fluid ports, so that the driving mechanism communicates with the plurality of detection channels through the plurality of fluid ports, respectively, after the at least one bio-detection chip is mounted to the chip mounting portion, thereby controllably driving the fluid flow in each of the detection channels. The biological detection device can simultaneously control the detection processes of different detection parameters of the same sample or different detection parameters of different samples, so that the energy consumed by the detection process is reduced, the detection time is shortened, the detection process is simplified, the detection efficiency is improved, and the use experience of a user is improved.

Description

Biological detection device and refrigerator

Technical Field

The invention relates to a refrigeration and freezing technology, in particular to a biological detection device and a refrigerator.

Background

With the improvement of living standard of people, pesticide residues, viruses, nutrient elements or other aspects of edible food materials are generally required to be detected in daily life so as to qualitatively or quantitatively acquire the conditions of the food materials. For example, due to the abuse problem of pesticides, fruits, vegetables and agricultural and sideline products purchased daily by people may have the problem of excessive pesticide residue content, and if the problem of excessive pesticide residue content of the foods cannot be found in time, the foods can cause great harm after being taken by human bodies. As another example, breast feeding advocated at present is the best for infants only when breast milk has normal nutritional value, but in cases of lactating mothers suffering from illness, taking medicine, surgery or other conditions, the nutritional content of milk secreted by the mothers may be reduced and viruses may be produced, thereby affecting the growth and health of the infants.

Among the detection methods, the method of detecting by using the biological detection chip is rapid, small in size and suitable for families. In order to facilitate the control of the detection process of the bioassay chip, a driving means may be used to drive the fluid flow in the bioassay chip. However, the existing biological detection device for biological detection chip can only control one detection flow path of one biological detection chip at a time, and if the user needs to detect a plurality of different samples or different parameters of the same sample, the user needs to install a plurality of biological detection chips on the biological detection device respectively for a plurality of times of detection, which wastes time and material, has high cost, needs to replace the chips for a plurality of times, and has complex operation and poor user experience effect.

Disclosure of Invention

It is an object of a first aspect of the present invention to overcome at least one of the disadvantages of the prior art and to provide a biological testing device capable of simultaneously controlling fluid flow in a plurality of test channels.

It is a further object of the first aspect of the invention to simplify the construction of the biological detection apparatus.

It is a further object of the first aspect of the invention to improve the accuracy of fluid flow control within each detection channel.

It is an object of a second aspect of the present invention to provide a refrigerator having the biological detection apparatus according to any of the above aspects.

According to a first aspect of the present invention, there is provided a biological detection apparatus comprising:

the biological detection chip comprises a bracket, a chip mounting part and a chip detection part, wherein the chip mounting part is used for mounting at least one biological detection chip, and a plurality of fluid interfaces which are in one-to-one correspondence communication with a plurality of detection channels formed in at least one biological detection chip are formed on the chip mounting part; and

and the driving mechanism is arranged on the bracket and is communicated with each fluid interface so as to enable the driving mechanism to be respectively communicated with the plurality of detection channels through the plurality of fluid interfaces after the at least one biological detection chip is installed on the chip installation part, thereby controllably driving the fluid in each detection channel to flow.

Optionally, a connection channel is formed in the support, one end of the connection channel is communicated with the driving mechanism, the other end of the connection channel is provided with a plurality of branch channels, and the plurality of branch channels are respectively communicated with the plurality of fluid interfaces in a one-to-one correspondence manner, so that the driving mechanism can simultaneously drive the fluid in the plurality of detection channels of the at least one biological detection chip installed in the chip installation portion.

Optionally, the drive mechanism is a micro syringe pump to induce fluid flow therein by forcing air into the detection channel.

Optionally, the drive mechanism comprises:

a driving motor for outputting a driving force;

the screw rod is connected with the driving motor and driven by the driving motor to rotate;

the sliding block penetrates through the screw rod and is in threaded connection with the screw rod so as to translate along the screw rod along with the rotation of the screw rod;

a syringe, a first end of which is communicated with the connecting channel; and

and the piston is arranged in the syringe and is fixedly connected with the sliding block so as to move in the syringe under the driving of the sliding block, so that the fluid in the detection channel is promoted to flow when the piston moves towards the first end of the syringe.

Optionally, one section of the driving motor connected with the screw rod is fixedly supported on the support, and one end of the driving motor departing from the screw rod and the circumferential side part of the driving motor are arranged at intervals with the support.

Optionally, the biological detection apparatus further comprises:

a position sensor for detecting a position of the slider to control operation of the driving motor by the position of the slider, thereby controlling a path of fluid flow in the detection passage by controlling a displacement amount of the piston in the syringe.

Optionally, the biological detection apparatus further comprises:

and the circuit board is fixed on the support, and the position sensor is arranged on the circuit board and is electrically connected with the circuit board.

Optionally, a protruding block protruding towards the circuit board is arranged on the slider, a through groove for the protruding block to move in is arranged on one side of the circuit board facing the slider, and the position sensor is adjacently arranged on the outer side of the through groove.

Optionally, the biological detection apparatus further comprises:

the front cover covers the front side of the bracket, and a notch is formed in the front cover;

the chip mounting portion is exposed to the front side of the front cover through the notch.

According to a second aspect of the present invention, there is also provided a refrigerator comprising the biological detection apparatus according to any one of the above aspects.

The biological detection device is provided with a chip mounting part for mounting the biological detection chip, a plurality of fluid interfaces which are correspondingly communicated with a plurality of detection channels one by one are formed on the chip mounting part, and the driving mechanism is communicated with the plurality of fluid interfaces simultaneously, so that the flow of fluid in the plurality of detection channels can be controlled simultaneously through the driving mechanism. The multiple detection channels can be respectively used for detecting different detection parameters of the same sample or different detection parameters of different samples, so that the biological detection device can simultaneously control the detection processes of different detection parameters of the same sample or different detection parameters of different samples, the energy consumed by the detection process is reduced, the detection time is shortened, the detection process is simplified, the detection efficiency is improved, and the use experience of a user is improved.

And, biological detection chip and actuating mechanism all set up on the support, and the biological detection device of being convenient for and biological detection chip form a system that overall arrangement is compact, structure integration to be convenient for with this system integration on refrigerator or other domestic appliance, do benefit to and accomodate, convenient to use.

Furthermore, the connecting channel for communicating the driving mechanism with the fluid interfaces is designed inside the support, so that the problems that the arrangement difficulty is large, the size is large and interference is easily caused with other structures due to the fact that the external connecting pipeline is connected between the driving mechanism and the fluid interfaces are avoided, the structure of the biological detection device is simplified, and the biological detection device is more suitable for being integrated on a refrigerator or other household appliances.

Furthermore, the displacement of the piston of the driving mechanism in the injector of the driving mechanism is controlled by detecting the position of the slide block of the driving mechanism through the position sensor, so that the flow path of fluid in the detection channel is controlled, the position of the piston and the displacement of the piston are conveniently monitored, and the accurate control of the flow path of the fluid is further realized.

The above and other objects, advantages and features of the present invention will become more apparent to those skilled in the art from the following detailed description of specific embodiments thereof, taken in conjunction with the accompanying drawings.

Drawings

Some specific embodiments of the invention will be described in detail hereinafter, by way of illustration and not limitation, with reference to the accompanying drawings. The same reference numbers in the drawings identify the same or similar elements or components. Those skilled in the art will appreciate that the drawings are not necessarily drawn to scale. In the drawings:

FIG. 1 is a schematic structural view of a biological detection apparatus according to one embodiment of the present invention;

FIGS. 2 and 3 are schematic exploded views of a biological testing device according to one embodiment of the invention in different orientations;

FIG. 4 is a schematic cross-sectional view of a biological testing device according to one embodiment of the present invention;

FIG. 5 is a schematic front perspective view of a biological testing device according to one embodiment of the present invention;

FIGS. 6 and 7 are schematic sectional views of a bioassay chip according to an embodiment of the present invention, taken along different cut lines, respectively;

FIG. 8 is a schematic sectional view after a bioassay chip according to an embodiment of the present invention is mounted to a bioassay device;

fig. 9 is a schematic enlarged view of a portion a in fig. 8;

FIG. 10 is a schematic flow chart of a control method of a bio-detection apparatus according to an embodiment of the present invention;

fig. 11 is a schematic structural view of a refrigerator according to one embodiment of the present invention;

fig. 12 is a schematic exploded view of a door body according to an embodiment of the present invention.

Detailed Description

The present invention first provides a biological detection apparatus. Fig. 1 is a schematic structural view of a biological detection apparatus according to an embodiment of the present invention, and fig. 2 and 3 are schematic exploded views of the biological detection apparatus according to an embodiment of the present invention in different orientations, respectively. Referring to fig. 1 to 3, the bioassay system 1 of the present invention includes a holder 10 and a driving mechanism 30.

The holder 10 has a chip mounting part 11 for mounting at least one bio-detection chip, and the chip mounting part 11 is formed with a plurality of fluid ports 111 for one-to-one communication with a plurality of detection channels formed in the at least one bio-detection chip. Specifically, the multiple detection channels may be independent of each other and do not affect each other. Also, a plurality of detection channels may be formed in a plurality of bio-detection chips, respectively, and at this time, the chip mounting part 11 may simultaneously mount a plurality of bio-detection chips. The multiple detection channels can also be formed in the same biological detection chip, and the multiple detection channels formed in the biological detection chip can be isolated from each other and are not communicated with each other. The biological detection chip is used for qualitatively or quantitatively detecting preset detection parameters of a sample, and the preset detection parameters can be pesticide residue parameters for indicating whether pesticide residue exceeds standard and/or specific values of pesticide residue, nutrient parameters for indicating whether nutrient elements reach standard and/or specific contents of nutrient elements, specific substance parameters for indicating whether specific harmful substances (such as specific viruses) exceed standard and/or specific contents, and the like.

The driving mechanism 30 is disposed on the holder 10 and is in communication with each of the fluid ports 111, so that the driving mechanism 30 is in communication with the plurality of detection channels through the plurality of fluid ports 111, respectively, after at least one bio-detection chip is mounted to the chip mounting portion 11, thereby controllably driving the fluid flow in each of the detection channels. That is, the drive mechanism 30 is in simultaneous communication with the plurality of fluidic interfaces 111, facilitating simultaneous control of fluid flow within the plurality of detection channels by the drive mechanism 30. The detection channels can be respectively used for detecting different detection parameters of the same sample or different detection parameters of different samples, so that the biological detection device 1 can simultaneously control the detection processes of different detection parameters of the same sample or different detection parameters of different samples, the energy consumed by the detection processes is reduced, the detection time is shortened, the detection processes are simplified, the detection efficiency is improved, and the use experience of a user is improved.

Moreover, the biological detection chip and the driving mechanism 30 are both supported on the support 10, so that the biological detection device 1 and the biological detection chip can form a biological detection system with compact layout and integrated structure, and the biological detection system can be integrated on a refrigerator or other household appliances, thereby being beneficial to storage and convenient use.

Fig. 4 is a schematic cross-sectional view of a biological detection apparatus according to an embodiment of the present invention, and fig. 5 is a schematic front perspective view of the biological detection apparatus according to an embodiment of the present invention. In some embodiments, a connection channel 12 is formed in the holder 10, one end of the connection channel 12 is communicated with the driving mechanism 30, and the other end has a plurality of branch channels 121, and the plurality of branch channels 121 are respectively communicated with the plurality of fluid ports 111 in a one-to-one correspondence, so as to simultaneously drive the fluid in the plurality of detection channels of the bioassay chip mounted in the chip mounting part 11 by the driving mechanism 30.

The connecting channel 12 for communicating the driving mechanism 30 with the fluid interfaces 111 is designed inside the support 10, so that the problems that the arrangement difficulty is high, the size is large and the interference with other structures is easily caused due to the fact that the connecting pipeline is externally connected between the driving mechanism 30 and the fluid interfaces 111 are avoided, the structure of the biological detection device 1 is simplified, and the biological detection device is more suitable for being integrated on a refrigerator or other household appliances.

Specifically, the chip mounting part 111 may be at the front side of the holder 10, facilitating the user to mount the bio-detection chip. The driving mechanism 30 may be disposed at the rear side of the frame 10 to prevent the frame from being exposed to the outside of the biological detecting device 1. The connecting channel 12 may also include an inclined channel 122 connected between the drive mechanism 30 and each of the branch channels 121. When the driving mechanism 30 is at the upper portion of the holder 10 and the chip mounting portion 111 is formed at the lower portion of the holder 10, the inclined passage 122 extends from the upper portion to the lower portion from the rear portion to the front portion.

In some embodiments, the drive mechanism 30 is a micro-syringe pump to induce fluid flow therein by pressurizing air into the detection channel. When the driving mechanism 30 injects air into the detection channel, the pressure in the detection channel increases, and the fluid in the detection channel flows under the action of the pressure difference between the inside and the outside of the detection channel.

Specifically, the driving mechanism 30 may include a driving motor 31, a lead screw 32, a slider 33, an injector 34, and a piston 35. The drive motor 31 is used to output a drive force. The lead screw 32 is connected to the driving motor 31 to be rotated by the driving motor 31. The sliding block 33 is arranged on the screw rod 32 in a penetrating way and is in threaded connection with the screw rod 32 so as to translate along the screw rod 32 along with the rotation of the screw rod 32. A first end of the syringe 34 communicates with the connecting passage 12. The piston 35 is disposed inside the syringe 34 and is fixedly connected to the slider 33 to move inside the syringe 34 under the driving of the slider 33, so as to promote the fluid flow inside the detection channel when moving toward the first end of the syringe 34.

Further, a section of the driving motor 31 connected with the screw rod 32 is fixedly supported on the bracket 10, and one end of the driving motor 31 departing from the screw rod 32 and a circumferential side of the driving motor 31 are both arranged at intervals from the bracket 10. That is, the driving motor 31 is not in contact with the support 10 except for the end fixedly connected to the support 10. Therefore, sufficient space is provided for heat dissipation of the driving motor 31, and timely dissipation of heat generated by the driving motor is facilitated. Further, the transmission of the vibration generated when the driving motor 31 is operated to other components (for example, a biological detection chip mounted on a chip mounting portion) on the holder 10 is reduced to some extent, and the influence on the other components is avoided.

Taking the biological detection apparatus 1 shown in fig. 1 to 5 as an example in a vertical state, the upper portion of the holder 10 may be formed with two receiving cavities, each of which is open toward the rear, for receiving the driving motor 31 and the syringe 34, respectively. The driving motor 31 can be accommodated in the first accommodating cavity 15 above, the bottom of the driving motor 31 is fixedly connected with the horizontally extending bottom plate 13 of the first accommodating cavity 15, and the top and the circumferential side of the driving motor 31 are respectively arranged at a certain distance from the top plate and the circumferential side plate of the first accommodating cavity 15. That is, the top and circumferential sides of the driving motor 31 do not contact other structures of the supporter 10. The screw rod 32 is connected to the bottom of the driving motor 31 and extends vertically. The syringe 34 is housed in the lower second housing chamber 16, and a first end of the bottom of the syringe 34 is in sealed communication with the connecting passage 12. The plunger 35 is inserted into the syringe 34 through a second end of the top of the syringe 34 and may be fixedly attached to the slider 33 by screwing, welding, gluing or other suitable means. When the slider 33 drives the piston 35 to move downward, the piston 35 pushes the air in the syringe 34, and further pushes the air in the detection channel of the bioassay chip in the chip mounting portion 11, so that a large pressure is generated inside the bioassay chip.

In some parameter detection, such as pesticide residue detection, the sample solution flowing out from the sampling chamber needs to enter a reaction chamber for containing a reaction reagent before entering the detection chamber, and the sample solution enters the detection chamber after reacting with the reaction reagent sufficiently to react with the detection reagent to obtain a detection result. Because the preparation of the sample liquid and the reaction between the sample liquid and the reaction reagent require time, and the detection channel of the biological detection chip is through after the biological detection chip is installed, the flow position and the flow time of the sample liquid in the detection channel need to be accurately controlled to ensure the accuracy of the detection result. That is, the amount and time of movement of the piston 35 during operation of the drive mechanism 30 are critical.

To this end, in some embodiments, the biological detection apparatus 1 further includes a position sensor 92, and the position sensor 92 is used for detecting the position of the slide block 33 to control the operation of the driving motor 31 according to the position of the slide block 33, so as to control the path of the fluid flow in the detection channel by controlling the displacement of the piston 35 in the injector 34, thereby facilitating the monitoring of the position of the piston 35 and the displacement of the movement thereof, and further realizing the precise control of the fluid flow path.

In some embodiments, the biological detection device 1 further includes a circuit board 93, the circuit board 93 being fixed to the support 10. Specifically, the circuit board 93 may be fixed to an upper portion of the bracket 10 at a front side of the driving mechanism 30. The upper portion of the bracket 10 may be forwardly extended with a plurality of claws 14 to thereby snap-fit the circuit board 93 thereto.

Further, the position sensor 92 may be provided on the circuit board 93, and electrically connected to the circuit board 93.

In some embodiments, the slider 33 is provided with a protrusion 331 protruding toward the circuit board 93, a side of the circuit board 93 facing the slider 33 is provided with a through groove 931 for the protrusion 331 to move therein, and the position sensor 92 is adjacently disposed outside the through groove 931 to detect the position of the protrusion 331, and thus the position of the slider 33.

In some embodiments, the biological detection apparatus 1 further includes a front cover 91, and the front cover 91 covers the front side of the support 10, so as to cover at least a part of the structure of the support 10 and prevent the support 10, the circuit board 93 mounted on the support 10, the driving mechanism 30, and the like from being exposed to the front side of the biological detection apparatus 1 to affect the appearance thereof.

Further, a notch 911 is formed in the front cover 91, and the chip mounting portion 11 is exposed to the front side of the front cover 91 through the notch 911, so that the bioassay chip is mounted to the chip mounting portion 11 through the notch 911.

FIGS. 6 and 7 are schematic sectional views of a bioassay chip according to an embodiment of the present invention, taken along different sectional lines, respectively, FIG. 8 is a schematic sectional view of a bioassay chip according to an embodiment of the present invention after being mounted to a bioassay device, and FIG. 9 is a schematic enlarged view of a portion A of FIG. 8. The bioassay chip 2 of the present invention is used in cooperation with the bioassay system according to any one of the above-described embodiments.

In particular, the bioassay chip 2 includes a plurality of detecting channels 20 arranged in parallel and independent of each other. It should be noted that the parallel arrangement means that the flow channels in the detection channels 20 are isolated and independent from each other, and the fluid in each detection channel does not flow through the other detection channels. That is, the detection channels 20 are not affected by each other, each detection channel 20 can independently detect one of the detection parameters of one sample, and the detection channels 20 can simultaneously detect a plurality of different samples or a plurality of different parameters of the same sample. Compared with the traditional biological detection chip which is only provided with one detection channel, the biological detection chip 2 saves materials required by detection, reduces the times of installing and replacing the chip by a user, thereby reducing the detection time, simplifying the detection process, improving the detection efficiency and improving the use experience of the user.

Specifically, a plurality of detection channels 20 are arranged side by side along the width direction of the bioassay chip 2, and each detection channel 20 extends along the length direction of the bioassay chip 2, so that the layout on the bioassay chip 2 is more compact, thereby reducing the volume of the bioassay chip 2 and making it more suitable for being integrated into a home appliance.

In some embodiments, each detection channel 20 has a detection chamber 23 for containing a detection reagent, a reaction chamber 22 for containing a reaction reagent, and a sampling chamber 21 for providing sample fluid to the reaction chamber 22 and the detection chamber 23 of the detection channel. The sampling chambers 21 of the respective detection channels 20 are independent of each other. That is, each detection channel 20 is independently sampled to allow each detection channel 20 to have a different sample fluid. The sampling chamber 21, the reaction chamber 22 and the detection chamber 23 of the same detection channel 20 are arranged in sequence along a predetermined direction (e.g., the length direction of the bioassay chip 2), so that the sample liquid in the sampling chamber 21 flows to the reaction chamber 22 and the detection chamber 23 in sequence.

Further, an extraction liquid is preset in the sampling chamber 21 to be mixed with the extraction liquid therein after the sample is set in the sampling chamber 21 to generate a sample liquid. When the sample liquid sampling device is used, a user only needs to put a sample into the sampling chamber, and a substance to be detected on the sample is dissolved into the extracting solution to form sample liquid with proper concentration, so that the complex operation of manually preparing the sample liquid by the user is omitted, and the operation convenience of detecting by using the biological detection chip 2 by the user is improved. The kind and amount of the extraction liquid in the sampling chambers 21 of the different detection channels 20 may be the same or different as necessary.

In some embodiments, the reagent is pre-positioned in the reaction chamber 22, so as to avoid the operation trouble caused by adding the reagent manually by a user or avoid the complicated structure caused by automatically adding the reagent by using a driving mechanism.

In some embodiments, the reaction reagent may be colloidal gold attached to the inner walls of the reaction chamber 22. The colloidal gold support arranged in this way is stable and not easy to move, so that the colloidal gold support is not easy to influence the sampling chamber 21 or the detection chamber 23 and is not easy to be influenced by the reagent in the sampling chamber 21 or the detection chamber 23.

In some embodiments, the detection reagent is pre-set in the detection chamber 23 to avoid the operation trouble of manually adding the detection reagent by a user or the structural complexity caused by automatically adding the detection reagent by using a driving mechanism.

In some embodiments, a test strip 60 is disposed in the detection chamber 23, the detection reagent is integrated on the test strip 60, and at least one side of the detection chamber 23 is open or transparent to facilitate observation of the detection result on the test strip 60 by a user.

In some embodiments, the sampling chamber 21, the reaction chamber 22, and the detection chamber 23 of each detection channel 20 are isolated from each other. Only after the bioassay chip 2 is mounted on the chip mounting part 11, the sampling chamber 21, the reaction chamber 22 and the detection chamber 23 of each detection channel 20 are communicated in sequence by the structural cooperation of the chip mounting part 11. Therefore, even if the sampling chamber 21, the reaction chamber 22 and the detection chamber 23 are pre-filled with reagents of corresponding types, no matter whether the reagents are in a gas state, a liquid state or a solid state, the mutual influence among the sampling chamber 21, the reaction chamber 22 and the detection chamber 23 can be effectively avoided, and the biological detection chip 2 can be stored for a long time on the premise of not losing efficacy.

Specifically, at least a part of the peripheral walls of the sampling chamber 21 and the reaction chamber 22 of each detection channel 20 are permeable walls to form at least one penetration hole under the action of the piercing structure on the chip mounting portion 11. The chip mounting part 11 is provided with a first piercing structure 51 having a first through passage 511 formed therein for piercing the penetrable wall 221 of the reaction chamber 22 and the penetrable wall 211 of the sampling chamber 21 of the same detection passage 20 after the bioassay chip 2 is mounted to the chip mounting part 11 and allowing fluid communication between the reaction chamber 22 and the sampling chamber 21 of the same detection passage 20 through the first through passage 511.

Further, the detection chamber 23 of each detection channel 20 has a liquid injection port 231 communicating with the inside thereof. The chip mounting part 11 is further provided with a second piercing structure 52 having a second through-passage 521 formed therein for piercing the penetrable wall 222 of the corresponding reaction chamber 22 after the bioassay chip 2 is mounted to the chip mounting part 11 and allowing the reaction chamber 22 to communicate with the liquid injection port 231 of the corresponding detection chamber 23 through the second through-passage 521.

That is, a first piercing structure 51 can be used to pierce and provide fluid communication between the penetrable walls of sampling chamber 21 and reaction chamber 22, and a second piercing structure 52 can be used to pierce and provide fluid communication between reaction chamber 22 and detection chamber 23. Therefore, complicated connecting pipelines are omitted, the structure is simplified, and the sampling chamber 21, the reaction chamber 22 and the detection chamber 23 of the biological detection chip 2 can be allowed to be arranged at intervals, thereby being beneficial to long-term storage of the biological detection chip 2 and allowing liquid reagents to be pre-stored in the sampling chamber, the reaction chamber or the detection chamber.

In some embodiments, the chip mounting portion 11 further has a plurality of sample-loading structures 70 corresponding to the sampling chambers 21 one by one, and each sample-loading structure 70 is configured to push the solid sample resting outside the corresponding sampling chamber 21 into the sampling chamber 21 when the biological detection chip 2 is mounted on the chip mounting portion 11, so that the solid sample is soaked in the extracting solution in the sampling chamber 21. The substance to be detected on the solid sample dissolves into the extracting solution to generate a sample solution. From this, can accomplish the application of sample operation automatically in the installation of biological detection chip 2, the user only need shelve solid-state sample outside sampling chamber 21 to directly install biological detection chip 2 can, need not other operations, also need not to set up the actuating mechanism of other supplementary applications of sample on biological detection device 1, simplified biological detection device 1's structure, reduced its cost, improved user's use and experienced, make it more suitable for the family to use.

Correspondingly, the outer side of each sampling chamber 21 is provided with a sampling port 24 for holding a solid sample, and the sampling ports 24 correspond to the positions of the sample adding structures 70 of the biological detection device 1 one by one, so as to allow each sample adding structure 70 to push the solid sample held at the corresponding sampling port 24 into the corresponding sampling chamber 21 when the biological detection chip 2 is mounted on the biological detection device 1. The sampling port 24 is separated from the sampling chamber 21 by another permeable wall 212 of the sampling chamber 21, and the sample loading structure 70 can penetrate the permeable wall 212 to push the sample into the sampling chamber 21.

Specifically, the sampling port 24 may be recessed toward the direction in which the sampling chamber 21 is located, so as to hold the solid sample therein and prevent the solid sample from falling. The plurality of thief hatches 24 may be spaced apart from one another, thereby forming a plurality of individual recesses. The plurality of thief hatches 24 may also be left unseated to form a complete recess.

The chip mounting portion 11 is further provided with a connection column which is in one-to-one correspondence with the sample adding structure 70 and is arranged adjacently, and the branch channel 121 is formed inside the connection column. After the bioassay chip 2 is mounted on the chip mounting portion 11, the penetrating wall 213 at the top of the corresponding sampling well 21 is penetrated by the connecting column, so that the branch passage 121 in the connecting column communicates with the corresponding sampling well 21.

The following describes in detail a control method for controlling the bio-detection chip mounted thereon using the bio-detection apparatus. Fig. 10 is a schematic flowchart of a control method of a bio-detection apparatus according to an embodiment of the present invention, which may include:

a step S10 of receiving a first trigger signal indicating that the bioassay chip 2 has been mounted on the chip mounting part 11;

step S20, waiting for a first preset time to fully dissolve the substance to be detected on the sample into the extracting solution in the sampling chamber 21, so as to form a sample solution with a proper concentration;

step S31, activating the driving mechanism 30 to drive the sample liquid in the sampling chamber 21 of each detection channel 20 to flow to the reaction chamber 22 of the detection channel through the driving mechanism 30;

step S32, determining whether the sample liquid flowing into the reaction chamber 22 reaches a preset sample amount; if yes, go to step S33; in this step, the position of the piston is detected, and when the piston moves to the preset position, it indicates that the sample liquid flowing into the reaction chamber 22 has reached the preset sample amount;

step S33, stopping the drive mechanism 30;

step S34, when the stopping time of the driving mechanism 30 reaches a second preset time, the driving mechanism 30 is started again to promote the sample liquid in the reaction chamber 22 of each detection channel 20 to flow to the detection chamber 23 of the detection channel 20;

and step S40, sending out prompt information for prompting that the detection result is shown after waiting for a third preset time.

Further, the control method of the present invention further includes:

when receiving the second trigger signal for instructing the removal of the bio-detection chip 2 from the chip mounting part 11, the piston controlling the driving mechanism 30 is restored to the initial position.

The present invention also provides a refrigerator, and fig. 11 is a schematic structural view of a refrigerator according to an embodiment of the present invention. The refrigerator 100 of the present invention includes the biological detection device 1 according to any of the above-described embodiments to integrate the biological detection device 1 into the refrigerator 100. The refrigerator 100 may further include a bio-detection chip 2 mounted on the bio-detection apparatus 1. The refrigerator 100 is frequently used in daily life, and the refrigerator 100 is mainly used for storing food materials, so that when the biological detection device 1 is integrated into the refrigerator 100, a user can conveniently perform a detection operation of a food material sample by using the biological detection device 1.

Further, the refrigerator 100 further includes a cabinet 200 and a door 300, wherein the cabinet 200 defines a storage space therein, and the door 300 is connected to the cabinet 200 and is used for opening and/or closing the storage space. The biological detection device 1 is preferably disposed on the door 300, which not only is convenient to operate, but also does not occupy the original storage space in the refrigerator body 200, and does not affect the storage capacity of the refrigerator 100.

Fig. 12 is a schematic exploded view of a door body according to an embodiment of the present invention. In some embodiments, the hollow window 301 is disposed at the front side of the door 300, and the chip mounting portion 11 is exposed to the front side of the door 300 through the hollow window 301, so that a user can mount the biological detection chip 2 to implement a detection function without opening the door 300, thereby ensuring the heat preservation performance of the refrigerator 100 and saving energy consumption.

Specifically, the door body 300 may include a panel 302 for forming a front portion thereof, a door liner 303 for forming a rear portion thereof, and a foam insulation layer (not shown) disposed between the panel 302 and the door liner 303, and the cutout window 301 is opened on the panel 302. An embedded box 304 is embedded between the panel 302 and the door liner 303 before the foaming heat-insulating layer is formed, and the biological detection device 1 is arranged in the embedded box 304. That is, the cassette 304 is provided in advance between the panel 302 and the door liner 303 before the door 300 is foamed, for reserving a space for installing the biological detection apparatus 1 between the panel 302 and the door liner 303.

Further, the embedded box 304 is attached to the rear surface of the panel 302, the front side of the embedded box 304 is open and faces the hollow window 301, so that the biological detection device 1 is allowed to be installed in the embedded box 304 from front to back through the hollow window 301, and the installation convenience of the biological detection device 1 is improved.

Further, the mounting posture of the biological detection chip 2 in the chip mounting portion 11 is set so that each detection channel 20 formed extends in the vertical direction. Thus, it is convenient for the user to install the biological detection chip 2, and it conforms to the operation habit of the user.

The refrigerator 100 of the present application is a refrigerator in a broad sense, and includes not only a so-called refrigerator in a narrow sense but also a storage device having a refrigerating, freezing or other storage function, for example, a refrigerator, a freezer, and the like.

It should be further understood by those skilled in the art that the terms "upper", "lower", "front", "rear", "top", "bottom", and the like used in the embodiments of the present invention are used with reference to the actual usage state of the bio-detection apparatus 1 and the refrigerator 100, and these terms are only used for convenience of description and understanding of the technical solutions of the present invention, and do not indicate or imply that the apparatus referred to must have a specific orientation, be configured and operated in a specific orientation, and thus, should not be construed as limiting the present invention.

Thus, it should be appreciated by those skilled in the art that while a number of exemplary embodiments of the invention have been illustrated and described in detail herein, many other variations or modifications consistent with the principles of the invention may be directly determined or derived from the disclosure of the present invention without departing from the spirit and scope of the invention. Accordingly, the scope of the invention should be understood and interpreted to cover all such other variations or modifications.

Claims (10)

1. A biological detection device, comprising:

the biological detection chip comprises a bracket, a chip mounting part and a chip detection part, wherein the chip mounting part is used for mounting at least one biological detection chip, and a plurality of fluid interfaces which are in one-to-one correspondence communication with a plurality of detection channels formed in at least one biological detection chip are formed on the chip mounting part; and

and the driving mechanism is arranged on the bracket and is communicated with each fluid interface so as to enable the driving mechanism to be respectively communicated with the plurality of detection channels through the plurality of fluid interfaces after the at least one biological detection chip is installed on the chip installation part, thereby controllably driving the fluid in each detection channel to flow.

2. The biological detection apparatus of claim 1,

a connecting channel is formed in the support, one end of the connecting channel is communicated with the driving mechanism, the other end of the connecting channel is provided with a plurality of branch channels, and the branch channels are respectively communicated with the plurality of fluid interfaces in a one-to-one correspondence manner so as to simultaneously drive the fluid in the plurality of detection channels of the at least one biological detection chip installed in the chip installation part through the driving mechanism.

3. The biological detection apparatus of claim 2,

the driving mechanism is a micro injection pump for promoting the fluid flow in the detection channel by pressing air into the detection channel.

4. The biodetection device of claim 3, wherein the drive mechanism comprises:

a driving motor for outputting a driving force;

the screw rod is connected with the driving motor and driven by the driving motor to rotate;

the sliding block penetrates through the screw rod and is in threaded connection with the screw rod so as to translate along the screw rod along with the rotation of the screw rod;

a syringe, a first end of which is communicated with the connecting channel; and

and the piston is arranged in the syringe and is fixedly connected with the sliding block so as to move in the syringe under the driving of the sliding block, so that the fluid in the detection channel is promoted to flow when the piston moves towards the first end of the syringe.

5. The biological detection apparatus of claim 4,

one section of the driving motor connected with the screw rod is fixedly supported on the support, and one end of the driving motor departing from the screw rod and the circumferential side part of the driving motor are arranged at intervals with the support.

6. The biological detection apparatus of claim 4, further comprising:

a position sensor for detecting a position of the slider to control operation of the driving motor by the position of the slider, thereby controlling a path of fluid flow in the detection passage by controlling a displacement amount of the piston in the syringe.

7. The biological detection apparatus of claim 6, further comprising:

and the circuit board is fixed on the support, and the position sensor is arranged on the circuit board and is electrically connected with the circuit board.

8. The biological detection apparatus of claim 7,

the slider is provided with a convex block protruding towards the direction of the circuit board, one side of the circuit board facing the slider is provided with a through groove for the convex block to move in, and the position sensor is adjacently arranged on the outer side of the through groove.

9. The biological detection device of claim 1, further comprising:

the front cover covers the front side of the bracket, and a notch is formed in the front cover;

the chip mounting portion is exposed to the front side of the front cover through the notch.

10. A refrigerator comprising the biodetection device of any one of claims 1-9.

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