CN211741318U

CN211741318U - Washing device for chemiluminescence immunity analyzer

Info

Publication number: CN211741318U
Application number: CN201922111957.4U
Authority: CN
Inventors: 高军宁; 王晓伟; 张永海
Original assignee: Weihai Weigao Biotechnology Co ltd
Current assignee: Weihai Weigao Biotechnology Co ltd
Priority date: 2019-11-30
Filing date: 2019-11-30
Publication date: 2020-10-23
Anticipated expiration: 2029-11-30

Abstract

The utility model relates to a chemiluminescence immunoassay analyzer manufacturing technical field, specific chemical immunity method that says so effectively improves washing device for optical analysis analyzer of washing effect under the prerequisite of not adding the washing number of times, its characterized in that the magnetic bead adsorption device is equipped with the magnet mounting panel, offers more than two magnet mounting grooves on the magnet mounting panel, sets up two magnets side by side from top to bottom in each magnet mounting groove, and the magnetic pole direction of two magnets that lie in the same magnet mounting groove is put conversely, and the magnetism of two magnets that lie in the same height in adjacent magnet mounting groove is inhaled the direction and is put conversely too; the magnet mounting panel or the rotary disk inside wall corresponding to the adsorption treatment initial position department still are equipped with the adsorption magnet mounting groove in advance, and a magnet is installed in the adsorption magnet mounting groove in advance.

Description

Washing device for chemiluminescence immunity analyzer

Technical Field

The utility model relates to a chemical luminescence immunoassay appearance manufacturing technical field, specific chemical immunity method light analytical instrument that says so effectively improves washing effect uses washing device under the prerequisite that does not add the washing number of times.

Background

A full-automatic chemiluminescence immunoassay analyzer is an ultramicro analysis device established by combining immunoreaction and luminescence analysis, for example, a full-automatic chemiluminescence immunoassay analyzer cleaning device disclosed in patent document CN103599898 provides a cleaning structure for the streamline cleaning of sample magnetic beads, but in the actual use process, the following defects exist in the existing products: (1) the lower needle position of the cleaning needle is positioned at the center of the reaction cup, so that a small amount of magnetic beads carrying effective substances can be sucked away when waste liquid is sucked, the magnetic beads are lost, and the cross contamination risk exists; (2) the magnetic bead adsorption equipment that its adopted adopts single magnet structure, and suction is weak, and consequently the magnetic bead adsorbs slowly, and single magnet knot constructs into the magnetic bead and adsorbs and be some or strip gathering, and consequently the magnetic bead forms many intermediate layers adsorption structure easily, leads to the unable clearance of impurity in the adjacent intermediate layer.

Disclosure of Invention

The utility model discloses to the shortcoming that exists among the prior art and not enough, provide one kind and effectively improved the washing device for chemical immunity method optical analysis appearance of washing effect under the prerequisite of washing number of times not adding.

The utility model discloses can reach through following measure:

a washing device for a chemical immunity method optical analyzer is provided with a magnetic bead adsorption mechanism, and is characterized in that the magnetic bead adsorption mechanism is provided with a magnet mounting plate, the magnet mounting plate is provided with more than two magnet mounting grooves, two magnets are arranged in each magnet mounting groove side by side from top to bottom, the magnetic pole directions of the two magnets positioned in the same magnet mounting groove are reversed, and the magnetic attraction directions of the two magnets positioned at the same height in the adjacent magnet mounting grooves are also reversed; the magnet mounting panel or the rotary disk inside wall corresponding to the adsorption treatment initial position department still are equipped with the adsorption magnet mounting groove in advance, and a magnet is installed in the adsorption magnet mounting groove in advance.

The utility model discloses correspond adsorption treatment initial position department on the magnet mounting panel, rotate the direction of advance along the reaction cup rotary disk, the parallel two magnet mounting grooves that adsorb in advance that set up respectively in every magnet mounting groove that adsorb in advance for before the washing process begins, carry out adsorption treatment in advance to the magnetic bead in the reaction cup, improve and adsorb the cleaning performance.

The utility model discloses still be equipped with reaction cup rotary disk, lift needle frame, set up the passageway that is used for passing through the sample on the reaction cup rotary disk, magnetic bead adsorption apparatus constructs the setting in the passageway side, the setting of lift needle frame is in the passageway top.

Be equipped with at least two sets of notes liquid imbibition combination needles on the lift needle frame, it comprises a imbibition needle and an notes liquid needle to annotate liquid imbibition combination needle, wherein imbibition needle lower extreme needle point position is less than annotates liquid needle lower extreme needle point position, and the needle point of annotating the liquid needle is buckled to the direction that is close to the imbibition needle, thereby when guaranteeing to absorb the waste liquid, the sample bottom in the reaction cup can be reachd to the needle point of imbibition needle, fully siphons away impurity, and when pouring into the washing liquid, the needle point of annotating the liquid needle is located imbibition needle point top, the washing liquid that notes liquid needle injected can wash the imbibition needle, in order to avoid polluting different samples.

Imbibition needle and notes liquid needle all set up the one side of skew magnet adsorption mechanism in the reaction cup top through lift needle frame to guarantee the imbibition needle when the imbibition, descend to the opposite side that the magnetic bead was adsorbed and is reunited in the reaction cup, avoid the magnetic bead to run off.

The magnet mounting plate of the utility model consists of a vertical plate and a bottom plate, the vertical plate and the bottom plate are vertically and fixedly connected, the cross section is in an L shape, more than two U-shaped grooves for placing magnets are arranged on the side surface of the vertical plate, the opening direction of the U-shaped grooves is upward, a pressing plate for closing the openings of the more than two U-shaped grooves is arranged on the top of the vertical plate, the pressing plate is fixedly connected with the top of the vertical plate through screws, and the bottom plate is provided with splicing teeth for being embedded with a rotating; two magnets which are arranged side by side up and down are arranged in a U-shaped groove on the side face of the vertical plate, and an antirust iron plate is arranged on the outer side of each magnet and used for strengthening magnetism; the vertical plate and the bottom plate are both in an arc shape which is matched with the inner side of the rotating disk main body, the rotating disk is provided with a reaction cup carrying track, the corresponding position of the washing position on the inner wall is provided with an installation notch which is used for assembling the magnet installation plate and communicated with the reaction cup carrying track, and the installation notch is provided with an installation groove matched with the assembling teeth.

The utility model discloses in the in-process of using, reaction cup rotary disk drives more than two reaction cups that hold the sample to be measured and advances according to setting for the direction, a actuating mechanism for driving reaction cup rotary disk pivoted can drive reaction cup rotary disk advance a reaction cup position at every turn, when washing processing begins, reaction cup gets into the preliminary adsorption treatment district at first under the drive of rotary disk, the single granule magnet in the preliminary adsorption magnet mounting groove on the magnet mounting panel carries out the preliminary adsorption treatment to the magnetic bead in the reaction cup, thereby make originally scattered magnetic bead in reaction cup whole space be close to one side that magnetic bead adsorption apparatus locates, when the rotary disk drives reaction cup and gets into two granule magnet adsorption districts and make, the magnetic bead is adsorbed on reaction cup is close to one side cup wall of magnet rapidly, owing to adopt two granule magnet to adsorb at this moment, the magnetic bead in the reaction cup is spread on reaction cup wall flatly, the reunion phenomenon effectively alleviates, the influence of impurities wrapped by multi-layer agglomerated magnetic beads on the cleaning effect is avoided; meanwhile, the lifting needle frame is driven by the needle frame driving mechanism to lift to complete the injection of the cleaning liquid and the absorption of the waste liquid, wherein the needle point position of the lower end of the liquid suction needle is lower than the needle point position of the lower end of the liquid injection needle, and the needle point of the liquid injection needle is bent towards the direction close to the liquid suction needle, so that when the waste liquid is absorbed, the needle point of the liquid suction needle can reach the bottom of the sample in the reaction cup to fully absorb impurities, when the cleaning liquid is injected, the needle point of the liquid injection needle is positioned above the needle point of the liquid suction needle, and the cleaning liquid injected by the liquid injection needle can flush the liquid suction needle, so that different; in addition, the liquid suction needle and the liquid injection needle are arranged on one side of the reaction cup above the magnet adsorption mechanism through the lifting needle frame, so that the liquid suction needle is ensured to descend to the opposite side of the reaction cup where magnetic beads are adsorbed and agglomerated when sucking liquid, and the magnetic beads are prevented from losing.

Compared with the prior art, the utility model, under the prerequisite that does not increase the washing number of times, can effectively improve the cleaning performance to reduce the loss of magnetic bead, have rational in infrastructure, easy and simple to handle, advantages that reliable operation etc. are showing.

Description of the drawings:

fig. 1 is a schematic structural diagram of the present invention.

Fig. 2 is a schematic structural diagram of the middle injection liquid suction combined needle of the present invention.

Fig. 3 is a sectional view taken along the line a-a in fig. 2.

Fig. 4 is a schematic structural diagram of the middle magnet mounting plate of the present invention.

Reference numerals: the device comprises a rotating disk 1, a lifting needle frame 2, a magnet 3, a pre-adsorption magnet mounting groove 4, a magnet mounting plate 5, a liquid injection and absorption combined needle 6, a liquid absorption needle 7, a liquid injection needle 8, a vertical plate 9, a bottom plate 10, a magnetic bead adsorption surface 11, a U-shaped groove 12, a pressing plate 13 and splicing teeth 14.

The specific implementation mode is as follows:

the present invention will be further described with reference to the accompanying drawings.

As shown in the attached figure 1, the utility model provides a washing device for a chemical immunity method optical analyzer, which is provided with a reaction cup rotating disc 1, a lifting needle frame 2 and a magnetic bead adsorption mechanism, and is characterized in that the magnetic bead adsorption mechanism is provided with a magnet mounting plate 5, more than two magnet mounting grooves are arranged on the magnet mounting plate 5, two magnets 3 are arranged in each magnet mounting groove side by side from top to bottom, the magnetic pole directions of the two magnets 3 positioned in the same magnet mounting groove are reversed, and the magnetic attraction directions of the two magnets 3 positioned at the same height in the adjacent magnet mounting grooves are also reversed; the magnet mounting panel 5 or correspond on the 1 inside wall of rotary disk and adsorb initial position department and still be equipped with in advance and adsorb magnet mounting groove 4, magnet of installation in the magnet mounting groove 4 in advance.

The utility model discloses correspond adsorption treatment initial position department on magnet mounting panel 5, rotate the direction of advance along the reaction cup rotary disk, parallel two of setting adsorb magnet mounting groove 4 in advance, every adsorbs magnet mounting groove 4 in advance respectively and sets up a magnet for before the washing process begins, carry out adsorption treatment in advance to the magnetic bead in the reaction cup, improve and adsorb the cleaning performance.

As shown in the attached drawing 2, be equipped with at least two sets of notes liquid imbibition combination needle 6 of annotating on the lift needle frame 2, it comprises a imbibition needle 7 and a notes liquid needle 8 to annotate liquid imbibition combination needle 6, wherein 7 lower extreme needle point positions of imbibition needle are less than annotate 8 lower extreme needle point positions of liquid needle, and annotate the needle point of liquid needle 8 and buckle to the direction that is close to imbibition needle 7, thereby when guaranteeing to absorb the waste liquid, the needle point of imbibition needle 7 can reach sample bottom in the reaction cup 9, fully absorb away impurity, and when pouring into the washing liquid, the needle point of annotating liquid needle 8 is located imbibition needle 7 needle point top, the washing liquid of annotating liquid needle 8 injection can wash the needle point of imbibition needle 7, in order to avoid polluting different samples.

As shown in the attached drawing 3, the liquid sucking needle 7 and the liquid injection needle are all arranged on one side of the deviating magnet adsorption mechanism above the reaction cup through the lifting needle frame 2, thereby ensuring that the liquid sucking needle 7 descends to the opposite side of the adsorption agglomeration of the magnetic beads in the reaction cup when sucking liquid, and avoiding the loss of the magnetic beads.

As shown in fig. 4, the magnet mounting plate 5 of the present invention is composed of a vertical plate 9 and a bottom plate 10, the vertical plate 9 and the bottom plate 10 are vertically and fixedly connected, and the cross section is L-shaped, the side surface of the vertical plate 9 is provided with more than two U-shaped grooves 12 for placing magnets, the opening direction of the U-shaped grooves 12 is upward, the top of the vertical plate 9 is provided with a pressing plate 13 for closing the openings of the more than two U-shaped grooves 12, the pressing plate 13 is fixedly connected with the top of the vertical plate 9 through screws, and the bottom plate 10 is provided with a jogged tooth 14 for jogg; two magnets which are arranged side by side up and down are arranged in a U-shaped groove on the side face of the vertical plate 9, an antirust iron plate is arranged on the outer side of each magnet and used for strengthening magnetism, and furthermore, a shading adhesive tape is pasted on the outer side of the antirust iron plate so as to improve the light shading performance of the whole mechanism; the vertical plate 9 and the bottom plate 10 are both in an arc shape which is matched with the inner side of the main body of the rotating disk 1, the vertical plate 9 and the bottom plate 10 are in an integrated structure, a reaction cup carrying track is arranged on the rotating disk 1, a mounting notch which is used for assembling the magnet mounting plate and is communicated with the reaction cup carrying track is arranged at the corresponding position of the washing position on the inner wall, and a mounting groove matched with the assembling teeth 14 is arranged on the mounting notch.

Claims

1. The utility model provides a chemistry immunity method is washing device for optical analysis appearance, is equipped with magnetic bead adsorption apparatus structure, its characterized in that magnetic bead adsorption apparatus structure is equipped with the magnet mounting panel, sets up two above magnet mounting grooves on the magnet mounting panel, sets up two magnet from top to bottom side by side in every magnet mounting groove, and the magnetic pole direction of two magnet that are located same magnet mounting groove is put conversely, and the magnetism that is located two magnet of same height in adjacent magnet mounting groove is inhaled the direction and is put conversely also.

2. The washing device for a chemical immunoassay optical analyzer according to claim 1, wherein a pre-attracting magnet installation groove is further provided on the inner side wall of the magnet installation plate or the rotary disk corresponding to the initial position of the adsorption treatment, and a magnet is installed in the pre-attracting magnet installation groove.

3. The washing device for the chemical immunoassay optical analyzer according to claim 1, wherein two pre-adsorption magnet mounting grooves are provided in parallel at positions on the magnet mounting plate corresponding to the start positions of the adsorption treatment along the forward direction of rotation of the rotating disk of the cuvette, and each pre-adsorption magnet mounting groove is provided with a magnet for pre-adsorbing beads in the cuvette before the washing process starts, thereby improving the adsorption cleaning effect.

4. The washing device for the chemical immunoassay optical analyzer as defined in claim 1, further comprising a rotating disk of the cuvette, a lifting needle holder, wherein the rotating disk of the cuvette is provided with a passage for passing the sample, the magnetic bead adsorption mechanism is disposed at a side of the passage, and the lifting needle holder is disposed above the passage.

5. The washing device for the chemoimmunoassay optical analyzer according to claim 4, wherein the lifting needle frame is provided with at least two sets of liquid injection and absorption combined needles, each of the liquid injection and absorption combined needles comprises a liquid suction needle and a liquid injection needle, wherein the lower end needle point of the liquid suction needle is lower than the lower end needle point of the liquid injection needle, and the needle point of the liquid injection needle is bent in a direction close to the liquid suction needle.

6. The washing device for the chemiluminescence immunoassay optical analyzer according to claim 5, wherein the liquid suction needle and the liquid injection needle are both arranged on the side of the reaction cup deviating from the magnet adsorption mechanism through the lifting needle frame.

7. The washing device for the chemical immunoassay optical analyzer according to claim 1, wherein the magnet mounting plate is composed of a vertical plate and a bottom plate, the vertical plate and the bottom plate are vertically and fixedly connected, the cross section of the vertical plate is in an L shape, more than two U-shaped grooves for placing magnets are arranged on the side surface of the vertical plate, the opening direction of the U-shaped grooves is upward, a pressing plate for closing the openings of the more than two U-shaped grooves is arranged on the top of the vertical plate, the pressing plate is fixedly connected with the top of the vertical plate through screws, and the bottom plate is provided with splicing teeth for being embedded with the rotary chassis; two magnets which are arranged side by side up and down are arranged in a U-shaped groove on the side face of the vertical plate, an antirust iron plate is arranged on the outer side of each magnet and used for strengthening magnetism, and a shading adhesive tape is pasted on the outer side of each antirust iron plate so as to improve the light shading performance of the whole mechanism; the vertical plate and the bottom plate are both in an arc shape which is matched with the inner side of the rotating disk main body, the rotating disk is provided with a reaction cup carrying track, the corresponding position of the washing position on the inner wall is provided with an installation notch which is used for assembling the magnet installation plate and communicated with the reaction cup carrying track, and the installation notch is provided with an installation groove matched with the assembling teeth.