CN105445481B - A kind of reactant oscillating uniform device - Google Patents
A kind of reactant oscillating uniform device Download PDFInfo
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- CN105445481B CN105445481B CN201510933411.0A CN201510933411A CN105445481B CN 105445481 B CN105445481 B CN 105445481B CN 201510933411 A CN201510933411 A CN 201510933411A CN 105445481 B CN105445481 B CN 105445481B
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- reaction cup
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00465—Separating and mixing arrangements
- G01N2035/00524—Mixing by agitating sample carrier
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
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- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The present invention discloses a kind of reactant oscillating uniform device, and it includes base, rotating disk and shakes up drive mechanism；Rotating disk is rotatablely connected base；Rotating disk is provided with more than 1 cleaning position, and reaction cup detent mechanism is provided with above rotating disk；The drive mechanism that shakes up includes mobile support, carriage drive motor and shakes up drive component；Base lower end is fixed with drive installation plate, mobile bracket slide connection drive installation plate, and can be moved up and down under the driving of carriage drive motor along drive installation plate；Respectively shake up in drive component, motor is shaken up to be installed on mobile support, extension rod one end, which is connected, shakes up the output shaft of motor, the other end is connected eccentric block, drive component is respectively shaken up to be respectively arranged at below rotating disk cleaning position, to cause eccentric block to stretch into reaction cup accommodating hole with the upward sliding of mobile support, reaction cup therein is jacked up to reaction cup detent mechanism and abutted against, and then eccentric block is under the driving for shaking up motor, drive reaction cup to do eccentric circular motion, reach the purpose for shaking up reactant.
Description
Technical field
The present invention relates to technical field of medical instruments, particularly a kind of reactant for chemiluminescence immunoassay response analysis
Oscillating uniform device.
Background technology
Immunoassay is the important means of clinic diagnosis, including the multiclass detection project such as virus, hormone, tumor markers.
Chemiluminescence immune assay is the newest immune detection skill to grow up after radio-immunity, fluorescence immunoassay, EIA enzyme immunoassay
Art, because chemiluminescence immune assay is without using any light source, the interference of bias light and veiling glare is avoided, reduces noise,
Signal to noise ratio is substantially increased, and nanogram level or the chemical composition of pieck stage can be determined, therefore chemiluminometry has spirit
The advantages that sensitivity is high, detection range is wide, label stability is good, turn into the most important hand of ion vitro immunization detection increasingly
Section.
Full-automatic chemiluminescence immunoassay analysis meter working method based on chemiluminescence mechanismic design is mainly sample-adding-temperature
Educate-cleaning-and measure four steps.Wherein cleaning is the key link of immune detection, and its major function is disposed in reaction cup
The free antibodies or antigen not being combined with magnetic bead and determined antigen or antibody, if the insufficient last measurement data of cleaning will
Very big deviation can be produced.Therefore how cleaning performance has very big influence to the performance parameter of instrument.
The cleaning device in luminescence immunoassay instrument, will with magnet substantially by the way of reaction cup is stood in the market
Magnetic bead is cleaned multiple times with cleaning needle again after adsorbing on static reaction cup wall of cup, and this kind of mode is because magnetic bead is only by one
Easily aggregation causes cleaning to separate and insufficient and influence experimental result for the suction in individual direction.
The content of the invention
The technical problem to be solved in the present invention is：By setting rotating disc type to shake up structure, reach the purpose for shaking up reactant,
So that excess reactant can be cleaned to greatest extent.
The technical solution used in the present invention is specially：A kind of reactant oscillating uniform device, including base, rotating disk and shake up drive
Motivation structure；
The rotating disk is rotatablely connected base；Circumferentially arranged with more than 1 reaction cup accommodating hole on rotating disk；It is provided with above rotating disk
Reaction cup detent mechanism that can be relative with reaction cup accommodating hole；
It is described to shake up drive mechanism to include mobile support, carriage drive motor and 1 installed above on mobile support
Shake up drive component；Base lower end is fixed with drive installation plate, mobile bracket slide connection drive installation plate, and can be driven in support
Moved up and down under the driving of dynamic motor along drive installation plate；
Respectively shaking up drive component includes shaking up motor, extension rod and eccentric block respectively；Motor is shaken up to be installed on
On mobile support, extension rod one end, which is connected, shakes up the output shaft of motor, and the other end is connected eccentric block, and the upper end of eccentric block is set
Having can be with the insertion mouth of reaction cup matching ends；Respectively shake up drive component to be respectively arranged at below rotating disk, to cause eccentric block
Can be stretched into the upward sliding of mobile support in reaction cup accommodating hole, by reaction cup therein jack up to reaction cup detent mechanism
Abut against, and then eccentric block drives reaction cup to do eccentric circular motion under the driving for shaking up motor.
The present invention in use, multiple reaction cup accommodating holes on rotating disk can be divided into prerinse position and current cleaning position,
The reaction cup that staff can shake up preparation cleaning is placed in prerinse position, treats current cleaning position end-of-job, you can rotate
Rotating disk causes cleaning position where reaction cup to be cleaned to turn to the top for shaking up drive component.Then carriage drive can be run
Motor so that mobile supporting band shakes even drive component and moved up, until eccentric block can jack up reaction cup in cleaning position extremely
Abutted against with detent mechanism；It can now run and shake up motor, be driven by extension rod, drive eccentric block to rotate, and then band
Dynamic reaction cup does eccentric circular motion, so as to reach the purpose for shaking up reactant in reaction cup.
Further, the reaction cup detent mechanism above heretofore described rotating disk includes spring leaf, top cap, is oriented to spiral shell
Post, stage clip and nut；Spring leaf one end is connected base, and guiding screw pole sequentially passes through the spring leaf other end, stage clip, top cap and nut
It is and fixed.When the reaction cup accommodating hole that rotating disk is rotated on cleaning position is can turn to below reaction cup detent mechanism, so that instead
It is inclined with lower section in guiding screw pole, stage clip and top cap insertion reaction rim of a cup, and under the elastic force effect of stage clip when answering the cup to be jacked up
Heart block clamps reaction cup together, ensures that reaction cup will not be offset in rotation process.
Further, in the present invention, the mobile support is by horizontal positioned mobile support plate and places vertically spacing
Plate is connected composition, and limiting plate is slidably connected drive installation plate by line slideway；Motor is shaken up to be installed on mobile support plate.
Specifically, carriage drive motor is fixedly installed in drive installation plate, and its output shaft extends vertically through drive installation
Be connected gear after plate, is provided with the rack being engaged with said gear on limiting plate, rack is vertically arranged.Then when carriage drive electricity
When machine is run, pinion rotation will be driven, and then gear is rolled on rack, while drives mobile support plate to move up, is made
Obtain eccentric block and jack up reaction cup.
Shake up in drive component, shake up and connected between the output shaft of motor and extension rod by shaft coupling；Extension rod
Outer to be arranged with sleeve pipe, sleeve pipe both ends are connected extension rod by bearing with end cover respectively, and its lower end is installed on by sleeve pipe fixed seat
On mobile support plate.
In the present invention, carriage drive motor can use direct current generator, shake up motor and use stepper motor, to above-mentioned electricity
Machine is driven to prior art.
In order to improve the efficiency that cleaning shakes up, the present invention is circumferentially provided with more than 5 reaction cup accommodating holes along rotating disk；Reaction
The quantity of cup detent mechanism is 5, and being correspondingly provided with one respectively below the rotating disk under each reaction cup detent mechanism shakes up drive
Dynamic component.5 cleaning positions can carry out shaking up cleaning to reaction cup simultaneously.
In order to buffer influence when mobile support plate moves up and down to reaction cup, the present invention can also be set in drive installation plate
Buffer.
Beneficial effects of the present invention are：, can be by making reaction cup do off-centre operation using the reactant oscillating uniform device of the present invention
Zhou Yundong, reach the purpose for shaking up reactant, lead to not what is rinsed well with magnetic bead easily aggregation during effective solution cleaning separation
Problem, substantially increase the Stability and veracity of instrument test.Meanwhile the rotating disk of more cleaning positions that sets of the present invention and more
Individual cleaning uniform shaking mechanism, it is available for multiple reaction cups to carry out while shakes up, efficiency is greatly improved.
Brief description of the drawings
Fig. 1 show the structural representation of the present invention；
Fig. 2 show front view of the present invention；
Fig. 3, which is shown, shakes up drive component structural representation.
Embodiment
Further described below in conjunction with the drawings and specific embodiments.
With reference to Fig. 1 to Fig. 3, reactant oscillating uniform device of the invention, including base 1, rotating disk 2 and shake up drive mechanism；
The rotating disk 2 is rotatablely connected base 1；Rotating disk 2 is provided with more than 1 reaction cup accommodating hole 21；The top of rotating disk 2 is provided with
Reaction cup detent mechanism that can be relative with reaction cup accommodating hole 21；
It is described to shake up drive mechanism to include mobile support, carriage drive motor 6 and 1 installed above on mobile support
Shake up drive component；The lower end of base 1 is fixed with drive installation plate 4, mobile bracket slide connection drive installation plate 4, and can prop up
Moved up and down under the driving of frame motor 6 along drive installation plate 4；
Respectively shaking up drive component includes shaking up motor 71, extension rod 72 and eccentric block 73 respectively；Shake up motor
71 are installed on mobile support, and the one end of extension rod 72, which is connected, shakes up the output shaft of motor 71, and the other end is connected eccentric block 73,
The upper end of eccentric block 73 is provided with the insertion mouth that can be engaged with the bottom of reaction cup 01；Respectively shake up drive component and correspond to one respectively
Reaction cup detent mechanism, the lower section of rotating disk 2 is arranged at, to cause eccentric block 73 to stretch into reaction cup with the upward sliding of mobile support
In accommodating hole 21, reaction cup 01 therein is jacked up to reaction cup detent mechanism and abutted against, and then eccentric block 73 is shaking up drive
Under the driving of dynamic motor 71, reaction cup 01 is driven to do eccentric circular motion.
Embodiment
In embodiment shown in Fig. 1, it is circumferentially provided with multiple reaction cup accommodating holes along rotating disk and forms multiple cleaning positions, cleans
The reaction cup detent mechanism of position top is 5, and one is correspondingly provided with respectively below the rotating disk under each reaction cup detent mechanism
Drive component is shaken up, a reaction cup can be corresponded to respectively at work and carry out shaking up cleaning.Can be by multiple cleaning positions on rotating disk
It is divided into prerinse position and current cleaning position, the reaction cup that staff can shake up preparation cleaning is placed in prerinse position, waits to work as
Preceding cleaning position end-of-job, you can rotate rotating disk and cause cleaning position where reaction cup to be cleaned turns to shake up drive component
Top.Then carriage drive motor can be run so that mobile supporting band shakes even drive component and moved up, until eccentric block
The reaction cup in cleaning position can be jacked up extremely to abut against with reaction cup detent mechanism；It can now run and shake up motor, by prolonging
Stock is driven, and drives eccentric block to rotate, and then drives reaction cup to do eccentric circular motion, is reacted so as to reach to shake up in reaction cup
The purpose of thing.
As shown in figure 3, the reaction cup detent mechanism of the top of rotating disk 2 includes spring leaf 31, top cap 33, guiding screw pole 32, pressure
Spring 34 and nut；The one end of spring leaf 31 is connected base 1, and guiding screw pole 32 sequentially passes through the other end of spring leaf 31, stage clip 34, top cap
33 and nut and fixation.When rotating disk 2 rotates, reaction cup accommodating hole 21 thereon is can turn to below reaction cup detent mechanism, from
And when make it that reaction cup 01 is jacked up, in 01 mouthful of guiding screw pole 32, stage clip 34 and 33 insertion reaction cup of top cap, and in stage clip 34
Under elastic force effect, reaction cup 01 is clamped together with lower section eccentric block 73, ensures that reaction cup 01 will not be offset in rotation process.
Fig. 1 and Fig. 2 are refer to, mobile support is connected by horizontal positioned mobile support plate 51 and the limiting plate 52 placed vertically
Composition, limiting plate 52 are slidably connected drive installation plate 4 by line slideway 41；Shake up motor 71 and be installed on mobile support plate 51
On.
Carriage drive motor 6 is fixedly installed in drive installation plate 4, and its output shaft 61 extends vertically through drive installation plate 4
Be connected gear 81 afterwards, is provided with the rack 82 being engaged with said gear 81 on limiting plate 52, rack 82 is vertically arranged.Then work as branch
It when frame motor 6 is run, will be rotated with moving gear 81, and then gear 81 is rolled on rack 82, while drive movement
Support plate 51 moves up so that eccentric block 73 jacks up reaction cup 01.
Shake up in drive component, shake up and connected between the output shaft of motor 71 and extension rod 72 by shaft coupling；Prolong
It is arranged with sleeve pipe 74 outside stock 72, the both ends of sleeve pipe 74 are connected extension rod 72 by bearing with end cover 75 respectively, and the lower end of sleeve pipe 74 passes through
Sleeve pipe fixed seat 76 is installed on mobile support plate 51.Shake up motor 71 and mobile support plate 51 is fixedly installed in by hexagonal double-ended bolt
On.
Carriage drive motor 6 can use direct current generator, shake up motor 71 and use stepper motor, the drive to above-mentioned motor
Move as prior art.
In order to buffer influence when mobile support plate 51 moves up and down to reaction cup, the present invention can also be set in drive installation plate
Put buffer 9.
Using the reactant oscillating uniform device of the present invention, it can reach by making reaction cup do eccentric circular motion and shake up reaction
The purpose of thing, solve the problems, such as that magnetic bead easily aggregation leads to not rinse well during cleaning separation, substantially increases instrument with effective
The Stability and veracity of test.Meanwhile rotating disk and the multiple cleaning uniform shaking mechanisms of the more cleaning positions of the invention set, it is available for
Multiple reaction cups shake up simultaneously, and efficiency is greatly improved.
Claims (4)
1. a kind of reactant oscillating uniform device, it is characterized in that, including base, rotating disk and shake up drive mechanism；
The rotating disk is rotatablely connected base；Circumferentially arranged with more than 1 reaction cup accommodating hole on rotating disk；Being provided with above rotating disk can be with
The relative reaction cup detent mechanism of reaction cup accommodating hole；
It is described to shake up drive mechanism to include mobile support, carriage drive motor and 1 installed above in shaking up on mobile support
Drive component；Base lower end is fixed with drive installation plate, and mobile bracket slide connects drive installation plate, and can be in carriage drive electricity
Moved up and down under the driving of machine along drive installation plate；
Mobile support is connected by horizontal positioned mobile support plate and the limiting plate placed vertically and formed, and limiting plate passes through line slideway
Be slidably connected drive installation plate；Motor is shaken up to be installed on mobile support plate；
Carriage drive motor is fixedly installed in drive installation plate, and its output shaft extends vertically through connected tooth after drive installation plate
Take turns, the rack being engaged with said gear is installed on limiting plate, rack is vertically arranged；
Respectively shaking up drive component includes shaking up motor, extension rod and eccentric block respectively；Shake up motor and be installed on movement
On support, extension rod one end, which is connected, shakes up the output shaft of motor, and the other end is connected eccentric block, and the upper end of eccentric block is provided with can
With the insertion mouth of reaction cup matching ends；Respectively shake up drive component respectively correspond to a reaction cup detent mechanism, be arranged at turn
Below disk, to cause eccentric block to be stretched into the upward sliding of mobile support in reaction cup accommodating hole, by reaction cup top therein
Rise and extremely abutted against with reaction cup detent mechanism, and then eccentric block drives reaction cup to do bias under the driving for shaking up motor
Circular motion；
The reaction cup detent mechanism includes spring leaf, top cap, guiding screw pole, stage clip and nut；Spring leaf one end is connected base,
Guiding screw pole sequentially passes through the spring leaf other end, stage clip, top cap and nut and fixation.
2. reactant oscillating uniform device according to claim 1, it is characterized in that, shake up in drive component, shake up motor
Output shaft and extension rod between connected by shaft coupling；Sleeve pipe is arranged with outside extension rod, sleeve pipe both ends pass through end-cover axle respectively
Connected extension rod is held, its lower end is installed on mobile support plate by sleeve pipe fixed seat.
3. reactant oscillating uniform device according to claim 1 or 2, it is characterized in that, carriage drive motor uses direct current generator,
Shake up motor and use stepper motor.
4. reactant oscillating uniform device according to claim 1 or 2, it is characterized in that, it is circumferentially provided with more than 5 instead along rotating disk
Answer cup accommodating hole；The quantity of reaction cup detent mechanism is 5, is corresponded to respectively below the rotating disk under each reaction cup detent mechanism
Drive component is shaken up provided with one.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510933411.0A CN105445481B (en) | 2015-12-15 | 2015-12-15 | A kind of reactant oscillating uniform device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510933411.0A CN105445481B (en) | 2015-12-15 | 2015-12-15 | A kind of reactant oscillating uniform device |
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| CN105445481A CN105445481A (en) | 2016-03-30 |
| CN105445481B true CN105445481B (en) | 2017-12-12 |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105749791A (en) * | 2016-04-19 | 2016-07-13 | 成都中牧生物药业有限公司 | Uniform mixing device on basis of different fixed sizes |
| CN107247133A (en) * | 2017-06-27 | 2017-10-13 | 苏州长光华医生物医学工程有限公司 | A kind of analyzer reaction system |
| CN109142767A (en) * | 2018-09-28 | 2019-01-04 | 基蛋生物科技股份有限公司 | Reaction cup oscillating uniform device and Chemiluminescence Apparatus |
| CN110586557B (en) * | 2019-09-11 | 2021-08-20 | 苏州长光华医生物医学工程有限公司 | Cleaning and separating device |
| CN111167352B (en) * | 2020-01-09 | 2022-04-01 | 深圳市博辰智控有限公司 | Liquid mixing system and method based on eccentric self-vibration |
| CN117907619B (en) * | 2024-03-18 | 2024-05-31 | 苏州长光华医生物医学工程有限公司 | Multi-station reaction cup transfer structure |
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| CN205374472U (en) * | 2015-12-15 | 2016-07-06 | 苏州长光华医生物医学工程有限公司 | Reactant shakes even device |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2007135921A1 (en) * | 2006-05-22 | 2007-11-29 | Olympus Corporation | Analytical instrument |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102147406A (en) * | 2011-02-14 | 2011-08-10 | 四川迈克生物科技股份有限公司 | Fully automatic chemical luminescent immune analyzer |
| CN203469887U (en) * | 2013-09-10 | 2014-03-12 | 博奥赛斯（天津）生物科技有限公司 | Liquid mixing device of chemiluminescent immunoassay analyzer |
| CN103592450A (en) * | 2013-11-28 | 2014-02-19 | 博奥赛斯（天津）生物科技有限公司 | Full-automatic chemiluminescence immunoassay analyzer |
| CN204134550U (en) * | 2014-09-25 | 2015-02-04 | 深圳市奥特库贝科技有限公司 | A kind of device for the mixing of magnetic particle |
| CN205374472U (en) * | 2015-12-15 | 2016-07-06 | 苏州长光华医生物医学工程有限公司 | Reactant shakes even device |
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