CN108614101A - A kind of magnetic particle Full-automatic chemiluminescence immunoassay analysis meter - Google Patents

Abstract

The invention discloses a kind of magnetic particle Full-automatic chemiluminescence immunoassay analysis meters, including rack, the rack both sides are equipped with the first sliding rail, and overarm brace is slidably connected on the sliding rail, the overarm brace is equipped with the second sliding rail, and sample arm and manipulator are slidably connected on second sliding rail；The first carrier and the second carrier are equipped with above the rack, on the left of rack, it is equipped with cup storehouse, cup disk grasping mechanism, incubation storehouse, wiper mechanism and cup on the right side of second carrier and takes inventory laying mechanism, it is connected with the first glass of feed mechanism and the second glass of feed mechanism on the incubation storehouse, second carrier rear is equipped with interpretation mechanism and cup transport mechanism, said mechanism are installed in rack.It is a kind of novel high flux, supports the Full-automatic chemiluminescence immunoassay analysis meter for not shutting down load sample and reagent, disclosure satisfy that the requirement of high-volume sample process, improve test efficiency.

Description

A kind of magnetic particle Full-automatic chemiluminescence immunoassay analysis meter

Technical field

The invention belongs to the field of medical instrument technology, more particularly to a kind of magnetic particle automatic chemiluminescence immunoassay Instrument.

Background technology

Chemiluminescence immune assay is the most fast immunoassay method of current popularization and application, and state-of-the-art label at present Immunoassay, sensitivity and accuracy ratio enzyme exempt from the high several orders of magnitude of method, fluorescence method.Magnetic particle refers to magnetic nano-particle The colloidal state composite material being dispersed in certain base fluid to be formed is combined with inorganic or organic molecule, it can be by enzyme, antibody, widow The bioactive substances such as nucleotide are fixed on its surface；Suspension magnetic particle has higher specific surface area as carrier, can Substantially more with example reaction, there is higher sensitivity, faster detection speed and better weight compared with ELISA Plate carrier The advantages that renaturation；Magnetic microparticle chemiluminescence immune assay technological synthesis magnetic particle carrier technique and chemiluminescence immunoassay detect skill Art keeps measurement result more acurrate, more stable.

At present in magnetic microparticle chemiluminescence instrument, since itself is limited, most sample needles only has 2 groups, and most 6 connect cup reaction Cup or most 3 groups of magnetic bead cleaning needle, the also factors such as machine layout, cause detection speed slower.The present invention uses 4 groups of sample-addings Needle, 8 connect cup reaction cup, and 2 groups of independent 8 needle magnetic bead cleaning needles, in addition rational deployment, test speed of the present invention greatly improves, and is 2 ~ 3 times of regular machinery speed；Simultaneously the present invention use new magnetic bead cleaning method, fill cleaning solution when, magnetic bead not by Group of magnets is adsorbed, and cleaning solution can break up magnetic bead, the ionized impurity between magnetic bead is released, and then magnetic bead is again by magnetic Iron group is adsorbed, and waste liquid needle siphons away the waste liquid containing impurity, and such magnetic bead cleaning is cleaner.

Goal of the invention

In view of the deficiencies of the prior art, it is an object of the present invention to provide a kind of magnetic particle Full-automatic chemiluminescence immunoassay analysis meter, Meet the requirement of high-volume sample process, improves test efficiency.

In order to achieve the above object, the present invention provides a kind of magnetic particle Full-automatic chemiluminescence immunoassay analysis meters, including Rack, the rack both sides are equipped with the first sliding rail, slidably connect overarm brace on the sliding rail, the overarm brace is equipped with Second sliding rail slidably connects sample arm and manipulator on second sliding rail；The first carrier and the are equipped with above the rack Two carriers are located on the left of rack, be equipped on the right side of second carrier cup storehouse, cup disk grasping mechanism, be incubated storehouse, wiper mechanism and Cup takes inventory laying mechanism, and the first glass of feed mechanism and the second glass of feed mechanism are connected on the incubation storehouse, and described second carries Frame rear is equipped with interpretation mechanism and cup transport mechanism, said mechanism are installed in rack.

As a kind of improvement of this programme, pallet entrance and display screen are additionally provided in front of the rack.

As being further improved for this programme, first carrier is suction nozzle and the cold storehouse carrier of reagent, second carrier For sample carrier, the two is to be connect with housing slide by sliding rail for drawer-type structure.

As being further improved for this programme, draw point is installed with by needle stand on the sample arm, is arranged on the draw point There is sleeve；The manipulator includes gripper mounting base, left-right rotary motor and crawl finger, and the crawl finger is two logical The both sides that the linear guide is symmetrically distributed in mechanical gripping mounting base are crossed, the lower section of the gripper mounting base is equipped with spring-loaded plunger and cup Detection plate.

As being further improved for this programme, the first tray supporter is equipped in the cup storehouse, on first tray supporter Side is equipped with the first glass of pallet, and first tray supporter is driven by first motor；The cup disk grasping mechanism includes cup disk Bottom plate, cup disk handgrip and secondary sample adding cup slot are captured, the cup disk handgrip is located above cup disk crawl bottom plate, one end and described two Secondary sample adding cup slot connection, the other end are inserted into the top inside glass storehouse for capturing cup bar pallet, are also set on the crawl bottom plate There are glass disk detection plate and the second motor.

As being further improved for this programme, the incubation storehouse is internally provided with incubation pallet, and the incubation storehouse is front and back respectively Equipped with into rim of a cup and cup mouth, above and below be equipped with heating plate, top is equipped with the first glass of feed mechanism and second glass of item Feed mechanism, first glass of feed mechanism is identical as the second glass of feed mechanism structure, and direction is on the contrary, include third electricity Machine, the first rack and cup push rod.

As being further improved for this programme, the wiper mechanism is magnetic force cup cleaner, including washes cup holder, described to wash cup holder Top, which is equipped with, washes a glass head, and the cup head of washing is equipped with cleaning needle and cleaning pipe, and the cup holder of washing is hollow structure, is internally provided with suction Attached plate, the adsorption plate move up and down washing in cup holder.

As being further improved for this programme, the adsorption plate is " 7 " font, is driven and is moved up and down by driving mechanism, The driving mechanism includes magnet steel lifting bottom plate, and magnet steel lifting bottom plate side is equipped with magnet steel and lifts riser, the magnet steel liter It drops riser and is equipped with magnet steel support plate and guide rail, the magnet steel support plate is slidably connected with the guide rail, the adsorption plate and the magnetic Steel support plate is fixedly connected, and as magnet steel support plate moves up and down together, and the magnet steel support plate is equipped with transverse groove；The magnet steel liter It drops floor and is equipped with the 4th motor, the 4th motor is equipped with first gear, and the first gear is engaged with second gear, institute The gear shaft for stating second gear probes into the transverse groove, and the second gear edge is additionally provided with deviation latch, and passes through this It is biased to latch to be connected in the transverse groove of magnet steel support plate, the 5th motor is additionally provided with below the magnet steel lifting bottom plate.

As being further improved for this programme, the interpretation device includes the interpretation pedestal for supporting and fixing modules, Reaction cup item for capturing manipulator automatically drives to the reaction cup transmission module of reading module cup inlet, is used for The reaction cup item that will be moved to reading module cup inlet is steadily pushed into reaction cup X in reading module to feeding module With the reading module read to reaction cup item；The reaction cup transmission module includes：It is right to be fixed in the interpretation pedestal The fixed seat at end, the front side top of the fixed seat are pivoted driven synchronous pulley, fixed 6th motor below rear side, and the described 6th The motor shaft of motor passes through an affixed active synchronization belt wheel after the fixed seat, and the driven synchronous pulley and the active are same Winding synchronous belt on belt wheel is walked, fixed Z-direction the linear guide in the fixed seat on the left of the synchronous belt, with the Z-direction straight line Guide rail, which is slidably matched, is arranged cup placement rack, and the cup placement rack is connected with the synchronous belt enables it in Z-direction simultaneously Bottom offset；The upper and lower side close to the fixed seat respectively fixed lenticular lenses and the first optoelectronic switch whether to ensure by reaction cup Item is moved to cup inlet；Setting shrapnel is to ensure the secured of reaction cup item in the cup placement rack；The reaction cup X Include the support base that left end is fixed on the interpretation pedestal to feeding module, opened up on the support base X to guide hole, with it is described The Z-direction through-hole that X is communicated to guide hole, the X, which is slidably matched to be arranged to guide hole, promotes rack, the fixed cup of right end for promoting rack Push rod；In fixed 7th motor in lower section corresponding to the Z-direction through-hole, the tooth being installed on the motor shaft of the 7th motor Wheel is located in the Z-direction through-hole and is meshed with the propulsion rack；In fixed second optoelectronic switch of the right end of the support base； The reading module includes cup feed arrangement, substrate filling apparatus, cup reading plotter and cup drop device；The cup item Feed arrangement includes the interpretation cup slot being fixed on the interpretation pedestal, and be pivoted three feed gear wheels on the interpretation cup slot, and three A feed gear wheel is driven to rotate synchronously by driving device and is continuously slowly advanced so that push-in is read the reaction cup item in cup slot, The second photoelectric sensor and third optoelectronic switch are set on the interpretation pedestal of the interpretation cup slot left end, close to described The first photoelectric sensor is set on the interpretation pedestal of interpretation cup slot right end；The substrate filling apparatus includes Z-direction rack, reads Cup slot plugging plate, the Z-direction rack drive it to move up and down along Z-direction by driving device, the connected bottom in upper end of the Z-direction rack Object filling head and substrate extraction tube；The cup reading plotter setting is being read to be protected from light completely when ensureing in reading in magazine, The cup reading plotter includes photomultiplier counter, the photomultiplier counter peripheral hardware lightshade cover, described to be protected from light Setting radiator fan in cover outside is to radiate to the photomultiplier counter；The cup drop device includes being located at institute State the discarding thumb wheel of interpretation pedestal left end.

As being further improved for this programme, it includes shell that the cup, which takes inventory laying mechanism, and the second support is equipped in the shell Disc carrier, the second tray supporter top are equipped with the second glass of pallet, and second tray supporter is driven by the 8th motor, Detection plate is equipped with above the shell, lower section is equipped with optoelectronic switch.

Compared with prior art, magnetic particle Full-automatic chemiluminescence immunoassay analysis meter of the invention is a kind of novel high pass Amount supports the Full-automatic chemiluminescence immunoassay analysis meter for not shutting down load sample and reagent, disclosure satisfy that high-volume sample process It is required that improving test efficiency.

Description of the drawings

Fig. 1 is the structural schematic diagram of magnetic particle Full-automatic chemiluminescence immunoassay analysis meter of the present invention.

Fig. 2 is the structural schematic diagram of the first carrier of the present invention.

Fig. 3 is the structural schematic diagram of the second carrier of the present invention.

Fig. 4 is the structural schematic diagram of the sample arm and manipulator of the present invention.

Fig. 5 is the structural schematic diagram in the cup storehouse and cup disk grasping mechanism of the present invention.

Fig. 6 is the structural schematic diagram in the incubation storehouse of the present invention.

Fig. 7 is the sectional view in the incubation storehouse of the present invention.

Fig. 8 is the structural schematic diagram of the wiper mechanism of the present invention.

Fig. 9 is the driving mechanism structure schematic diagram of the wiper mechanism of the present invention.

Figure 10 is the absorption plate structure schematic diagram of the wiper mechanism of the present invention.

Figure 11 is the structural schematic diagram of the interpretation device of the present invention.

Figure 12 is that the cup of the present invention takes inventory the structural schematic diagram of laying mechanism.

Specific implementation mode

The specific implementation mode of the present invention is described in detail come further below by the form in conjunction with attached drawing, But what following embodiment was only enumerated is more preferably embodiment, only plays the role of explanation to help to understand the present invention, It can not be not understood as limitation of the invention.

The embodiment of the present invention is described below in detail, examples of the embodiments are shown in the accompanying drawings, wherein from beginning to end Same or similar label indicates same or similar element or element with the same or similar functions.

The embodiments described below with reference to the accompanying drawings are exemplary, it is intended to for explaining the present invention, and cannot understand For limitation of the present invention.

In the description of the present invention, it is to be understood that, term "center", " longitudinal direction ", " transverse direction ", " length ", " width Degree ", " thickness ", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", " up time The orientation or positional relationship of the instructions such as needle ", " counterclockwise " is to be based on the orientation or positional relationship shown in the drawings, and is merely for convenience of The description present invention and simplified description, do not indicate or imply the indicated device or element must have a particular orientation, with spy Fixed azimuth configuration and operation, therefore be not considered as limiting the invention.

In addition, term " first ", " second " are used for description purposes only, it is not understood to indicate or imply relative importance Or implicitly indicate the quantity of indicated technical characteristic.Define " first " as a result, the feature of " second " can be expressed or Implicitly include one or more this feature.In the description of the present invention, unless otherwise indicated, the meaning of " plurality " is two It is a or more than two, unless otherwise restricted clearly.

In the present invention unless specifically defined or limited otherwise, term " installation ", " connected ", " connection ", " fixation " Equal terms shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection, or be integrally connected；Can be Mechanical connection can also be electrical connection；It can be directly connected, can also can be indirectly connected through an intermediary two Connection inside element.For the ordinary skill in the art, above-mentioned term can be understood at this as the case may be Concrete meaning in invention.

In the present invention unless specifically defined or limited otherwise, fisrt feature the "upper" of second feature or "lower" It may include that the first and second features are in direct contact, can also not be to be in direct contact but pass through it including the first and second features Between other characterisation contact.Moreover, fisrt feature second feature " on ", " top " and " above " include first special Sign is right over second feature and oblique upper, or is merely representative of fisrt feature level height and is higher than second feature.Fisrt feature exists Second feature " under ", " lower section " and " following " include fisrt feature immediately below second feature and obliquely downward, or be merely representative of Fisrt feature level height is less than second feature.

Embodiment：Shown in Fig. 1, a kind of magnetic particle Full-automatic chemiluminescence immunoassay analysis meter, including rack 1, the rack 1 Both sides are equipped with the first sliding rail 2, and overarm brace 3 is slidably connected on first sliding rail 2, and the overarm brace 3 is equipped with second Sliding rail 4 slidably connects sample arm 5 and manipulator 6 on second sliding rail 4；1 top of the rack is equipped with 7 He of the first carrier Second carrier 8, is located at 1 left side of rack, and second carrier, 8 right side is equipped with cup storehouse 9, cup disk grasping mechanism 10, is incubated storehouse 11, is clear Washing machine structure 12 and cup take inventory laying mechanism 13, be connected on the incubation storehouse 11 the first glass of feed mechanism 14 and second glass of item to Into mechanism 15,8 rear of the second carrier is equipped with interpretation mechanism 16 and cup transport mechanism 17, and said mechanism is installed in rack On 1.Disposable tip maximum capacity is 576；Maximum reagent volumes, conventional reagent can place 84 pipes, and magnetic bead reagent 5 is managed；One Secondary maximum sample number is 192, there is 2 group of 8 needle cleaning head, can clean 28 company's cup cup items simultaneously, the present invention is a kind of novel height Flux supports the Full-automatic chemiluminescence immunoassay analysis meter for not shutting down load sample and reagent.

1 front of the rack is additionally provided with pallet entrance 18 and display screen 19.

Wherein, shown in Fig. 2, first carrier 7 is suction nozzle and the cold storehouse carrier of reagent, suction nozzle carrier and the cold storehouse carrier of reagent It for drawer-type structure, is fixed in rack 1, can integrally be pulled out by three folding sliding rails, 6 96 hole suction nozzle pallets can be put, maximum is inhaled Head capacity is 576；The cold the top of the warehouse of reagent is equipped with reagent Hatch Board, and for heat-insulated, bottom is that reagent platform and refrigeration aluminium sheet are solid It being scheduled on together, for ceramic cooling piece between refrigeration aluminium sheet and Al squeezing material, 2 aerofoil fan heat dissipations are installed in Al squeezing material bottom, A hot wind part is discharged from agent bin mounting plate bottom space by aerofoil fan, and excess heat passes through rack-mounted whirlpool It takes turns fan to be discharged on the left of rack, maximum can place 14 6 reagent strips in cold storehouse, and 5 magnetic bead reagent bottles are shaking up in bottle holder It can rotate and shake up automatically；There are RF signal plates in drawer panel, is used for reading reagent radio frequency label information；System software is according to reading The radio frequency label information taken selects the corresponding test method of this reagent；There is in mechanical hook cooperation rack lock and micro- behind carrier Dynamic switch is used together, and when hook is locked in rack, while microswitch closes, and closure signal is transmitted to control system, when pulling open When carrier, hook abjection lock, microswitch signal disconnects, and such carrier can be realized not shut down and mend suction nozzle and replace reagent.

Shown in Fig. 3, second carrier 8 is sample carrier, and sample carrier is drawer-type structure, is fixed by three folding sliding rails In rack 1, have to latch in mechanical hook cooperation rack behind sample carrier and be used together with microswitch, with suction nozzle carrier and The cold storehouse carrier usage of reagent is identical, pull panel button hand position can be completely pulled out, with realize do not shut down replace test tube item frame sample and Dilute the dilution in dilution plate on carrier；When user is inserted into test tube item frame, barcode scanning head can be led on edge automatically under motor driving Rail moves to the suitable position apart from test tube item frame, opens the bar code on barcode scanning head scanned samples test tube；Sample carrier most one The secondary sample size that goes up is 192.

Shown in Fig. 4, it is the special draw point 21 of disposable tip that sample arm 5, which uses four needle sample arms, front end, is covered on draw point 21 Sleeve 22 is used for detecting whether have suction nozzle on draw point 21, and draw point 21 is fixed on the hub 20.

Shown in Fig. 4, manipulator 6 is dual-purpose mechanical gripper, mainly by the linear guide 26,24,2 crawl hands of left-right rotary motor Refer to 25,2 spring-loaded plungers 27, cup detection plate 28 and gripper mounting base 23 form, the crawl finger 25 for two and The both sides of mechanical gripping mounting base 23 are symmetrically distributed in by the linear guide 26, the lower section of the gripper mounting base 23 is equipped with spring Plunger 27 and cup detection plate 28.Cup item realizes crawl, cup detection plate by capturing partly to be closed on finger with spring-loaded plunger For detecting whether to capture successfully；It is closed realization crawl empty pallet by capturing finger lower part, loses step using left-right rotary motor It detects to check whether to catch empty pallet.

Shown in Fig. 5, cup storehouse 9, the cup storehouse 9 is interior to be equipped with the first tray supporter 29, and first tray supporter, 29 top is set There are the first glass of pallet 30, first tray supporter 29 to be driven by first motor 31.

Shown in Fig. 5, the cup disk grasping mechanism 10, including cup disk crawl bottom plate 32, cup disk handgrip 33 and secondary sample adding cup Slot 34, the cup disk handgrip 33 are located at 32 top of cup disk crawl bottom plate, and one end is connect with the secondary sample adding cup slot 34, the other end The top inside glass storehouse 9 is inserted into for capturing cup bar pallet 30, a glass disk detection plate is additionally provided on the cup disk crawl bottom plate 32 35 and second motor 36.Cup holding capacity of bin can be 15 cup bar pallets, pallet be stored in by left-right and front-back storehouse board group at it is rectangular There are corresponding 15 detection plates in space, on back bin plate, for checking that storehouse inner pallet state, system software are controlled by control panel Motor drives tray supporter, and pallet is driven to move up and down；When being manually pushed into cup bar pallet from pallet entrance, tray supporter is transported downwards Dynamic, until buying securities with all one's capital, touch display screen prompts state of buying securities with all one's capital, and makes a sound warning.

Cup disk grasping mechanism 10 is mainly by motor, and cup disk handgrip, secondary sample adding cup slot, cup disk captures bottom plate and cup disk detects Plate；Cup disk handgrip is inserted into Bei Cang mechanisms, is fixed on cup handgrip by bottom hook handle cup bar pallet, pulls out pallet, so After do experiment, sample and reagent are added in glass item.

Shown in Fig. 6, Fig. 7, it is incubated storehouse 11, the incubation storehouse 11, which is internally provided with, is incubated pallet 37, before and after the incubation storehouse 11 Be respectively equipped with into rim of a cup 38 and cup mouth 39, above and below be equipped with heating plate, top is equipped with the first glass of feed mechanism 40 With the second glass of feed mechanism 41, first glass of feed mechanism 40 includes third motor 42, the first rack 43 and cup item Push rod 44；Second glass of article of feed mechanism 41 includes the 4th motor 45, the second rack 46 and cup article pull rod 47.Into rim of a cup 38 Nearby have a cup detection plate with cup mouth 39, cup detection plate be used for detection cup item whether completely into or leave 18 and be incubated support Disk, being incubated tray top and bottom has heating plate, and it is heat-insulated that both sides are incubated storehouse left side plate；

The first glass of feed mechanism 40（To incubation）, mainly by driving motor, rack and cup push rod composition, cup item sample-adding is completed Afterwards, 18 incubation positions for being incubated pallet are moved into rim of a cup in order, and handle cup item promotes incubation pallet to cup push rod in order.

The second glass of feed mechanism 41（To washing station）, mainly by the cup pull rod of solenoid actuated, rack, the linear guide and Driving motor forms；When having glass item to be incubated completion in incubation pallet, 18 incubation positions for being incubated pallet move on to out cup in order Mouthful, then cup pull rod, which moves on to, is incubated pallet incubation position, and compression cup pull rod, pull rod block a glass item, be dragged to and wash under electromagnet is powered Cup item frame, electromagnet power-off, pull rod deviate from cup item.

Fig. 8, shown, wiper mechanism 12 is magnetic force glass washing machine structure, including washes cup holder 48, it is described wash 48 top of cup holder and be equipped with wash Cup head 49, the cup head 49 of washing are equipped with cleaning needle 50 and cleaning pipe 51, and the cup holder 48 of washing is hollow structure, is internally provided with suction Attached plate 52, the adsorption plate 52 are washing up and down motion in cup holder 48.

Fig. 9, shown in 10, the adsorption plate 52 is " 7 " font, is driven and is moved up and down by driving mechanism, the driving machine Structure includes magnet steel lifting bottom plate 53, and 53 side of the magnet steel lifting bottom plate is equipped with magnet steel and lifts riser 54, and the magnet steel lifting is vertical Plate 54 is equipped with magnet steel support plate 55 and guide rail 56, and the magnet steel support plate 55 is slidably connected with the guide rail 56, the adsorption plate 52 It is fixedly connected with the magnet steel support plate 55, and as magnet steel support plate 55 moves up and down together, the magnet steel support plate 55 is equipped with cross To slot；Magnet steel lifting bottom plate 53 is equipped with the 5th motor 57, and the 5th motor 57 is equipped with first gear 58, and described the One gear 58 is engaged with second gear 59, and the gear shaft 60 of the second gear 59 probes into the transverse groove, second tooth It takes turns 59 edges and is additionally provided with deviation latch 61, and be connected in the transverse groove of magnet steel support plate 55 by the deviation latch 61, institute It states 53 lower section of magnet steel lifting bottom plate and is additionally provided with the 6th motor 62.

Wiper mechanism 12 is independently washed cup station by front and back 2 and is formed, and preceding 8 needles for washing cup station wash a glass head, there is 8 injection needles and 8 A waste liquid needle, being separately connected liquid injection pipe and sewer pipe can move up and down, and can clean 18 company's cup item simultaneously, greatly improve cleaning effect Rate；Fluid injection and sewer pipe are controlled by peristaltic pump respectively；The magnet steel combination that wheel drive with teeth inside glass item frame moves up and down is washed, is being noted When liquid needle notes cleaning solution, magnet steel group is parked in minimum point, does not adsorb magnetic bead, and fluid injection at this time can be by magnetic bead mixing, while by subtracting Shake rubber column gel column shakes magnetic bead, reinforcement magnetic bead with the fixed glass item frame of washing of preceding Y-direction motion under the drive of bottom eccentric shaking motor Mixed effect, then the rise of magnet steel group, cup side wall is adsorbed on by magnetic bead, and waste liquid needle siphons away waste liquid, is repeated several times in this way, can be incited somebody to action Magnetic bead cleans up, more preferable than conventional method cleaning performance, finally washes a glass item frame and is moved along Y-direction, and a glass position, dual-purpose machine are washed in removal Tool handgrip handle cup item is caught away；After to wash cup station similar with cup station is before washed, 8 needles wash the connection fluid injection of cup head and sewer pipe, can clean 1 simultaneously Item 8 connects cup item；Fluid injection and sewer pipe are controlled by peristaltic pump respectively；Cup is washed in the magnet steel combination cooperation for washing glass item frame internal gear driving Head Washing cup magnetic bead is washed glass item frame in the case where bottom eccentric shaking motor drives by damping rubber column gel column and rear Y-direction motion and is shaken Swing magnetic bead；2 are washed the autonomous working of cup station, greatly improve cup cleaning speed.

Drag chain is moved by rack along the linear guide before preceding Y-direction motion drives, drag chain after rear Y-direction motion drives It is moved along the linear guide by rack.Preceding hose fixed plate and rear hose fixed plate fixed liquid injection pipe and sewer pipe.

The operation principle of cup transport mechanism：Motor drives lifting cup carrier to be transported up and down along the linear guide by synchronous belt It is dynamic；Motor will lift the cup item in cup carrier and interpretation mechanism, optoelectronic switch promoted to be used for examining by rack drives cup push rod Survey push rod position.

Shown in Figure 11, interpretation mechanism includes supporting and fixing the interpretation pedestal of modules, for grabbing manipulator automatically The reaction cup item taken drives to the reaction cup transmission module of reading module cup inlet, for will be moved to reading module cup The reaction cup X that the reaction cup item of inlet is steadily pushed into reading module is read to feeding module and to reaction cup item Several reading modules.

The reaction cup transmission module includes：It is fixed in the fixed seat 64 of 63 right end of interpretation pedestal, the fixation The front side top of seat 64 is pivoted driven synchronous pulley, fixed 7th motor 69 below rear side, the motor shaft of the 7th motor 69 An affixed active synchronization belt wheel after the fixed seat 64, on the driven synchronous pulley and the active synchronization belt wheel around If synchronous belt, fixed Z-direction the linear guide 66 in the fixed seat 64 on the left of the synchronous belt, with the Z-direction the linear guide 66 Be slidably matched setting cup placement rack 65, and the cup placement rack 65 is connected with the synchronous belt enables it in Z-direction simultaneously Bottom offset；The upper and lower side close to the fixed seat 64 respectively fixed lenticular lenses 67 and the first optoelectronic switch 68 to ensure whether to Reaction cup item is moved to cup inlet；Setting shrapnel is to ensure the secured of reaction cup item in the cup placement rack 65.

The reaction cup X is described to the support base 70 that feeding module includes that left end is fixed on the interpretation pedestal 63 Open up the Z-direction through-hole 85 that X is communicated to guide hole, with the X to guide hole on support base 70, the X is pushed away to the guide hole setting that is slidably matched Into rack 71, the fixed cup push rod of right end 73 for promoting rack 71；In the lower section corresponding to the Z-direction through-hole 85 fixed Eight motors 72, the gear being installed on the motor shaft of the 8th motor 72 be located in the Z-direction through-hole 85 and with the propulsion Rack 71 is meshed；In fixed second optoelectronic switch of the right end of the support base 70 74.

The reading module includes cup feed arrangement, substrate filling apparatus, cup reading plotter and cup drop device； The cup feed arrangement includes the interpretation cup slot 76 being fixed on the interpretation pedestal 63, is pivoted three on the interpretation cup slot 76 A feed gear wheel 77, three feed gear wheels 77 are driven by driving device to be rotated synchronously will be pushed into the reaction read in cup slot Cup item is continuously slowly advanced, and the second photoelectric sensor 81 is arranged on the interpretation pedestal 63 of 76 left end of interpretation cup slot With third optoelectronic switch 69, the first photoelectric sensor is set on the interpretation pedestal 63 of 76 right end of interpretation cup slot 75；The substrate filling apparatus includes Z-direction rack 78, reads cup slot plugging plate 79, and the Z-direction rack 78 is driven by driving device It moves up and down along Z-direction, the connected substrate filling head in upper end and substrate extraction tube of the Z-direction rack 78；The cup item reading dress It installs and is reading to be protected from light completely when ensureing in reading in magazine 82, the cup reading plotter includes that photomultiplier counts Device, the photomultiplier counter peripheral hardware lightshade cover 83,83 outside setting radiator fan 84 of the lightshade cover is with to the light Electric multiplier tube counter radiates；The cup drop device includes the discarding thumb wheel positioned at 63 left end of interpretation pedestal 86。

The workflow of interpretation mechanism：All gear does not pass through by 2 partial gears in reading camera bellows and the 3rd of left side The synchronous belt of closure connects together, it can be achieved that rotate synchronously, and is driven by motor；When cup push rod handle cup item is shifted onto along cup guide groove The 1st partial gear position in camera bellows, gear start to rotate, and cup item is driven to advance, and are read when cup item goes to photomultiplier Several mouthfuls of positions, motor drive rack move downward, and the substrate injection head for being fixed on rack top moves down on the 1st reaction rim of a cup Side fills luminous substrate, shines in reaction cup, interpretation mechanism is read simultaneously, and rack moves up, and cup item moves on 1 cup, substrate Injection head moves down filling substrate, while waste liquid needle siphons away waste liquid in the 1st cup, prevents its reading from influencing the 2nd glass, and then It shines in 2 cups, reading；Remaining reaction cup is shone in order after the completion of reading, and partial gear handle cup item takes camera bellows out of, after It is continuous to advance, fall into dustbin（Immediately below desorption head plate）；Optoelectronic switch is used for determining partial gear position；

Shown in Figure 12, cup takes inventory laying mechanism 13 and is used for placing the empty pallet for being taken empty cup item on sample-adding position, including shell 86, described It is equipped with the second tray supporter 87 in shell 86, second tray supporter, 87 top is equipped with the second glass of pallet 88, and described second Tray supporter 87 is driven by the 9th motor, and 87 top of the shell is equipped with detection plate 89, and lower section is equipped with optoelectronic switch 90.In sky When not having pallet in pallet magazine, motor rises to initial position with synchronous belt driving tray supporter is crossed along the linear guide, and photoelectricity is opened It closes and is used for detecting the zero-bit on tray supporter；Synchronous belt is rotated around driven wheel；When thering is empty pallet to be placed on tray supporter, Pallet detection plate can detect that pallet, system software controls tray supporter move down one, until 15 empty pallets are all piled, so Display screen prompt user takes empty pallet away afterwards；User often takes an empty pallet away, and tray supporter can rise one automatically, until complete Portion takes light empty pallet.

Present invention be primarily characterized in that manually disposable tip, reagent, after sample and the addition of cup bar pallet, cup disk is grabbed Mechanism is taken to haul out one group of cup bar pallet from cup storehouse, then four needle sample arms use disposable tip, and sample and reagent are added to In the reaction cup of cup item, first glass of feed mechanism（To incubation）Handle cup item promotes incubation pallet to cup push rod in order, is incubating It educates storehouse and is incubated the defined time, then the second glass of feed mechanism（To washing station）Cup pull rod handle cup item is pulled out from pallet is incubated, It is dragged to and washes a glass item frame cleaning magnetic bead；

It is tested if it is 1 footwork, then dual-purpose mechanical gripper catches the cup item cleaned the lifting cup item load of cup transport mechanism In frame, carrier drops to interpretation mechanism cup item and leads notch position, and cup push rod promotes cup item by the cup item in cup carrier is lifted Guide groove, partial gear continue transmission cup item and enter interpretation mechanism, then add luminous substrate by cup, shine reading, whole reading After the completion, partial gear continuation handle cup item is sent to dustbin；

It is tested if it is 2 footworks, then the cup item cleaned is caught secondary sample-adding position pallet by dual-purpose mechanical gripper, in this position four Needle sample arm is added to reagent in the reaction cup of glass item, first glass of feed mechanism（To incubation）Cup push rod handle cup item again It promotes and is incubated pallet, be incubated the defined time being incubated storehouse, then the second glass of feed mechanism（To washing station）Cup pull rod handle cup Item is pulled out from pallet is incubated, and is dragged to and is washed after the completion of glass item frame cleaning magnetic bead, the cup item cleaned is caught cup by dual-purpose mechanical gripper The lifting cup carrier of transport mechanism, cup head enter back into interpretation mechanism and substrate are added to shine reading, finally enter dustbin.

Although the embodiments of the present invention has been shown and described above, it is to be understood that above-described embodiment is example Property, it is not considered as limiting the invention, those skilled in the art are not departing from the principle of the present invention and objective In the case of can make changes, modifications, alterations, and variations to the above described embodiments within the scope of the invention, it is carried out simply Combination variation be all classified as the present invention protection within.

Claims (10)

1. a kind of magnetic particle Full-automatic chemiluminescence immunoassay analysis meter, including rack（1）, it is characterised in that：The rack（1）Two Side is equipped with the first sliding rail（2）, first sliding rail（2）On slidably connect overarm brace（3）, the overarm brace（3）On set There is the second sliding rail（4）, second sliding rail（4）On slidably connect sample arm（5）And manipulator（6）；The rack（1）Top Equipped with the first carrier（7）With the second carrier（8）, it is located at rack（1）Left side, second carrier（8）Right side is equipped with cup storehouse（9）、 Cup disk grasping mechanism（10）, be incubated storehouse（11）, wiper mechanism（12）And cup takes inventory laying mechanism（13）, the incubation storehouse（11）On It is connected with the first glass of feed mechanism（14）With the second glass of feed mechanism（15）, second carrier（8）Rear is equipped with interpretation Mechanism（16）With cup transport mechanism（17）, said mechanism is installed in rack（1）On.

2. magnetic particle Full-automatic chemiluminescence immunoassay analysis meter according to claim 1, it is characterised in that：The rack （1）Front is additionally provided with pallet entrance（18）And display screen（19）.

3. magnetic particle Full-automatic chemiluminescence immunoassay analysis meter according to claim 1, it is characterised in that：Described first carries Frame（7）For suction nozzle and the cold storehouse carrier of reagent, second carrier（8）For sample carrier, the two is to pass through for drawer-type structure Sliding rail and rack（1）It is slidably connected.

4. magnetic particle Full-automatic chemiluminescence immunoassay analysis meter according to claim 1, it is characterised in that：The sample arm （5）On pass through needle stand（20）It is installed with draw point（21）, the draw point（21）On be arranged with sleeve（22）；The manipulator（6）Packet Include gripper mounting base（23）, left-right rotary motor（24）And crawl finger（25）, the crawl finger（25）It is for two and logical Cross the linear guide（26）It is symmetrically distributed in mechanical gripping mounting base（23）Both sides, the gripper mounting base（23）Lower section be equipped with Spring-loaded plunger（27）With cup detection plate（28）.

5. magnetic particle Full-automatic chemiluminescence immunoassay analysis meter according to claim 1, it is characterised in that：The cup storehouse （9）Inside it is equipped with the first tray supporter（29）, first tray supporter（29）Top is equipped with the first glass of pallet（30）, described One tray supporter（29）Pass through first motor（31）Driving；The cup disk grasping mechanism（10）Bottom plate is captured including cup disk（32）、 Cup disk handgrip（33）With secondary sample adding cup slot（34）, the cup disk handgrip（33）Bottom plate is captured positioned at cup disk（32）Top, one end With the secondary sample adding cup slot（34）Connection, the other end are inserted into a glass storehouse（9）Internal top is for capturing cup bar pallet（30）, The cup disk captures bottom plate（32）On be additionally provided with a glass disk detection plate（35）With the second motor（36）.

6. magnetic particle Full-automatic chemiluminescence immunoassay analysis meter according to claim 1, it is characterised in that：The incubation storehouse （11）It is internally provided with incubation pallet（37）, the incubation storehouse（11）It is front and back to be respectively equipped with into rim of a cup（38）And cup mouth（39）, on Side and lower section are equipped with heating plate, and top is equipped with the first glass of feed mechanism（40）With the second glass of feed mechanism（41）, described The first glass of feed mechanism（40）Including third motor（42）, the first rack（43）And cup push rod（44）；Described second glass Feed mechanism（41）Including the 4th motor（45）, the second rack（46）And cup pull rod（47）.

7. magnetic particle Full-automatic chemiluminescence immunoassay analysis meter according to claim 1, it is characterised in that：The cleaning machine Structure（12）For magnetic force cup cleaner, including wash cup holder（48）, described to wash cup holder（48）Top is equipped with and washes a glass head（49）, described to wash a glass head （49）It is equipped with cleaning needle（50）And cleaning pipe（51）, described to wash cup holder（48）For hollow structure, it is internally provided with adsorption plate（52）, The adsorption plate（52）Washing cup holder（48）Interior up and down motion.

8. magnetic particle Full-automatic chemiluminescence immunoassay analysis meter according to claim 7, it is characterised in that：The adsorption plate （52）It for " 7 " font, is driven and is moved up and down by driving mechanism, the driving mechanism includes magnet steel lifting bottom plate（53）, described Magnet steel lifts bottom plate（53）Side is equipped with magnet steel and lifts riser（54）, the magnet steel lifting riser（54）It is equipped with magnet steel support plate （55）And guide rail（56）, the magnet steel support plate（55）With the guide rail（56）It is slidably connected, the adsorption plate（52）With the magnetic Steel support plate（55）It is fixedly connected, and with magnet steel support plate（55）It moves up and down together, the magnet steel support plate（55）It is equipped with laterally Slot；The magnet steel lifts bottom plate（53）It is equipped with the 5th motor（57）, the 5th motor（57）It is equipped with first gear（58）, The first gear（58）With second gear（59）Engagement, the second gear（59）Gear shaft（60）Probe into the transverse groove It is interior, the second gear（59）Edge is additionally provided with deviation latch（61）, and pass through the deviation latch（61）It is connected to magnet steel Support plate（55）Transverse groove in, the magnet steel lifts bottom plate（53）Lower section is additionally provided with the 6th motor（62）.

9. magnetic particle Full-automatic chemiluminescence immunoassay analysis meter according to claim 1, it is characterised in that：The interpretation dress The interpretation pedestal including supporting and fixing modules is set, the reaction cup item for capturing manipulator automatically drives to interpretation mould The reaction cup transmission module of block cup inlet, for will be moved to the reaction cup item of reading module cup inlet steadily The reading module that reaction cup X in push-in reading module is read to feeding module and to reaction cup item；The reaction cup Transmission module includes：It is fixed in the interpretation pedestal（63）The fixed seat of right end（64）, the fixed seat（64）Front side on Fixed 7th motor below the driven synchronous pulleys of Fang Shushe, rear side（69）, the 7th motor（69）Motor shaft pass through it is described Fixed seat（64）An affixed active synchronization belt wheel, the driven synchronous pulley are synchronous with winding in the active synchronization belt wheel afterwards Band, the fixed seat on the left of the synchronous belt（64）Upper fixed Z-direction the linear guide（66）, with the Z-direction the linear guide（66） Be slidably matched setting cup placement rack（65）, the cup placement rack（65）It is connected and enables it to along Z with the synchronous belt simultaneously To upper and lower displacement；Close to the fixed seat（64）Upper and lower side distinguish fixed lenticular lenses（67）With the first optoelectronic switch（68）With Ensure whether reaction cup item is moved to cup inlet；The cup placement rack（65）Interior setting shrapnel is to ensure reaction cup item It is secured；The reaction cup X includes that left end is fixed on the interpretation pedestal to feeding module（63）On support base（70）, institute State support base（70）On open up the Z-direction through-hole that X is communicated to guide hole, with the X to guide hole（85）, the X is slidably matched to guide hole Setting promotes rack（71）, the propulsion rack（71）The fixed cup push rod of right end（73）；Corresponding to the Z-direction through-hole （85）Fixed 8th motor in lower section（72）, it is installed in the 8th motor（72）Motor shaft on gear be located at the Z-direction Through-hole（85）It is interior and with the propulsion rack（71）It is meshed；In the support base（70）Fixed second optoelectronic switch of right end （74）；The reading module includes cup feed arrangement, substrate filling apparatus, cup reading plotter and cup drop device；Institute It includes being fixed on the interpretation pedestal to state cup feed arrangement（63）On interpretation cup slot（76）, the interpretation cup slot（76）Upper pivot If three feed gear wheels（77）, three feed gear wheels（77）It drives to rotate synchronously by driving device and reads cup slot will be pushed into Interior reaction cup item is continuously slowly advanced, close to the interpretation cup slot（76）The interpretation pedestal of left end（63）Upper setting second Photoelectric sensor（81）With third optoelectronic switch（69）, close to the interpretation cup slot（76）The interpretation pedestal of right end（63）On First photoelectric sensor is set（75）；The substrate filling apparatus includes Z-direction rack（78）, read cup slot plugging plate（79）, the Z To rack（78）It is driven to move up and down along Z-direction by driving device, the Z-direction rack（78）Upper end be connected substrate filling head With substrate extraction tube；The cup reading plotter setting is in reading magazine（82）It is interior with ensure reading when be protected from light completely, it is described A cup reading plotter includes photomultiplier counter, the photomultiplier counter peripheral hardware lightshade cover（83）, described to be protected from light Cover（83）Radiator fan is arranged in outside（84）To radiate to the photomultiplier counter；The cup drop device Including being located at the interpretation pedestal（63）The discarding thumb wheel of left end（86）.

10. magnetic particle Full-automatic chemiluminescence immunoassay analysis meter according to claim 1, it is characterised in that：The cup disk Holding structure（13）Including shell（86）, the shell（86）Inside it is equipped with the second tray supporter（87）, second tray supporter （87）Top is equipped with the second glass of pallet（88）, second tray supporter（87）It is driven by the 9th motor, the shell （87）Top is equipped with detection plate（89）, lower section is equipped with optoelectronic switch（90）.