CN204203240U - A kind of chemiluminescence immune assay evenly mixing device - Google Patents
A kind of chemiluminescence immune assay evenly mixing device Download PDFInfo
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- CN204203240U CN204203240U CN201420576122.0U CN201420576122U CN204203240U CN 204203240 U CN204203240 U CN 204203240U CN 201420576122 U CN201420576122 U CN 201420576122U CN 204203240 U CN204203240 U CN 204203240U
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Abstract
The utility model is created and is provided a kind of chemiluminescence immune assay evenly mixing device, and described device comprises chassis, cleaning part, mixing portion and rotating disk.Vertical-lifting driven by motor vertical-lifting screw mandrel in cleaning part rotates, then drive be positioned at vertical-lifting screw mandrel top needle stand linearly guide rail move up and down.Minute hand and hour hand are fixed on needle stand by pin cutting ferrule.The top of lower supporting rod is connected with needle stand, and reaction cup is fixed by mixing bearing assembly under lower supporting rod controls.Mixing portion, by mixing Electric Machine Control, drives Timing Belt to rotate, and then drive mixing shaft assembly to rotate, now reaction cup position is corresponding with mixing shaft assembly, rotates, complete mixing under the spin friction of mixing shaft assembly drives.Rotating disk comprises inner disc, outer disk and reaction tray, and reactive tank is positioned in reaction tray, and pipe bucket is positioned on inner disc.The beneficial effect that the utility model is created it is possible to the cleaning mixing of reaction cup and substrate to mix complete fast within one device, and device structure is simple, easy to use.
Description
Technical field
The invention belongs to automatic chemiluminescence immunoassay apparatus field, especially relates to a kind of chemiluminescence immune assay evenly mixing device.
Background technology
Luminescence immunoassay is the novel ultramicro-analysis technology of one that luminesceence analysis and immune response are combined and set up.This technology utilizes chemistry or bio-luminescence system as the indication mechanism of antigen-antibody reaction, so as to the method for quantitative detectable antigens or antibody.The high sensitivity of this method with luminesceence analysis and the high degree of specificity of antigen-antibody reaction.
At present, in existing full-automatic immunoluminescence analyser, the absorption of most employing magnetic bead is extracted waste liquid and magnetic bead and is added cleaning fluid and mix the frame mode that two functions are separated, reaction tube needs to be moved around between the two positions by other servicing units, flow process is more complicated, is unsuitable for composition robotization cleaning.In addition, existing equipment mixes after also the reaction tube cleaned will being transferred to and adding substrate in another equipment again, improves volume and the complicacy of equipment, improves manufacturing cost and the maintenance cost of equipment simultaneously.
Summary of the invention
The problem that the invention will solve is, provides a kind of chemiluminescence immune assay evenly mixing device, is especially applicable to solving current magnetic bead reaction cup cleaning mixing and mixes the problem that can not realize fully automatic integral with substrate.
For solving the problems of the technologies described above, the technical scheme that the invention adopts is:
A kind of chemiluminescence immune assay evenly mixing device is provided, comprise chassis, cleaning part, mixing portion and rotating disk, vertical-lifting driven by motor vertical-lifting screw mandrel in cleaning part rotates, then drive be positioned at vertical-lifting screw mandrel top needle stand linearly guide rail move up and down, minute hand and hour hand are fixed on needle stand by pin cutting ferrule; Mixing portion is by mixing Electric Machine Control, and mixing motor is opened and driven Timing Belt to rotate, and drives mixing shaft assembly to rotate by synchrodrive; The top of lower supporting rod is connected with needle stand, and mixing bearing assembly is positioned in the outer disk of rotating disk, can realize under the control of lower supporting rod in rotating disk reaction tray draw close or away from and reaction cup is clamped or unclamps.
Wherein, described mixing shaft assembly comprises cleaning mixing shaft assembly and substrate mixing shaft assembly, described cleaning mixing shaft assembly drives large synchronous pulley by Timing Belt and rotates, described substrate mixing shaft assembly drives small synchronous pulley by Timing Belt, then realizes rotating by driving with small synchronous pulley meshed gears.
Wherein, described mixing shaft assembly comprises RUBBER O type pipe and mixing axle; RUBBER O type pipe box is on mixing axle.
Wherein, described mixing portion also comprises spacing ring, and described spacing ring is fixed in rotating disk outer disk, and the difference in height between reaction tray is not less than the vertical height of reaction cup.
Wherein, described rotating disk comprises inner disc, outer disk, reaction tray, magnet groove and pipe bucket, and mixing motor is connected with reaction tray center, drives reaction tray to rotate by meshed transmission gear; Outer disk is connected with reaction tray by bearing with inner disc; Outer disk is provided with magnet groove, magnet groove is built-in with magnet; Reaction tray is provided with reaction cup groove; Inner disc is provided with pipe bucket.
Wherein, described minute hand is consistent with hour hand quantity, and described pipe bucket is equidistant to be positioned on inner disc.
The advantage that the invention has and good effect are: by an Electric Machine Control, form different mixing speed by gears meshing, and cleaning mixing and substrate that a rotating disk achieves reaction tube mix two reactions steps.Simultaneously by the cooperation of vertical-lifting Electric Machine Control long and short hands, the injection of cleaning fluid and the extraction of cleaning waste liquid can be realized fast, the real reaction tube that automatically achieves injects from cleaning fluid-cleans the step mixing-clean the mixing of waste liquid extraction-substrate, reduces device structure complicacy and manufacturing cost etc.
Accompanying drawing explanation
Fig. 1 is the one-piece construction schematic diagram of the invention
In figure:
1, chassis 2, cleaning part 2-1 vertical-lifting motor
2-2, vertical-lifting screw mandrel 2-3, line slideway 2-4, needle stand
2-5, minute hand 2-6, hour hand 2-7, pin cutting ferrule
2-8 lower supporting rod 3, mixing portion 3-1, mixing motor
3-2, large synchronous pulley 3-3, cleaning mixing shaft assembly 3-4, small synchronous pulley
3-5, mixing bearing assembly 3-6, spacing ring 4, rotating disk
4-1 outer disk 4-2, inner disc 4-3, reaction tray
4-4, reactive tank 4-5, magnet groove 4-6, Guan Tong
Embodiment
Elaborate below in conjunction with the specific embodiment of accompanying drawing to the invention.
As shown in Figure 1, the invention comprises chassis, cleaning part, mixing portion and rotating disk, vertical-lifting driven by motor vertical-lifting screw mandrel in cleaning part rotates, then drive be positioned at vertical-lifting screw mandrel top needle stand linearly guide rail move up and down, minute hand and hour hand are fixed on needle stand by pin cutting ferrule; The top of lower supporting rod is connected with needle stand; Mixing portion drives by mixing motor, and mixing motor is opened and driven Timing Belt to rotate, and the synchronous mixing shaft assembly that drives rotates then; Mixing bearing assembly be positioned in the outer disk of rotating disk, there is projection the lower end of lower supporting rod, when needle stand at top time, the lower end projection of lower supporting rod makes mixing bearing assembly open, and expanded diameter is greater than reaction cup diameter.Described rotating disk comprises inner disc, outer disk, reaction tray, magnet groove and pipe bucket, and mixing motor is connected with reaction tray center, then drives pinion wheel to rotate, thus drives the reaction tray engaged with pinion wheel to rotate (gear is processed in reaction tray outer ring); Outer disk is connected with reaction tray by bearing with inner disc; Outer disk is provided with magnet groove, magnet groove is built-in with strong magnets; Reaction tray is provided with reaction cup groove; Inner disc is provided with pipe bucket.
Wherein, a described cleaning mixing shaft assembly and the cleaning mixing bearing assembly of correspondence, a lower supporting rod, a minute hand and a hour hand form a cleaning mixing operate portions; It is a substrate mixing operate portions that a substrate mixing bearing assembly of a substrate mixing shaft assembly and correspondence adds a lower supporting rod.The invention has four cleaning mixing operate portions and a substrate mixing operate portions.
The invention course of work: the first step, vertical-lifting electric motor starting, vertical-lifting screw mandrel is driven to rotate, then drive be positioned at vertical-lifting screw mandrel top needle stand linearly guide rail move upward, the lower support bar be now connected with needle stand runs to topmost, lower supporting rod controls cleaning mixing bearing assembly and opens, and then magnetic bead reaction cup to be cleaned be placed on and mix in reactive tank corresponding to operate portions with cleaning, the magnetic bead in simultaneous reactions cup is by the magnet adsorption in rotating disk outer disk.
Second step, vertical-lifting motor drives vertical-lifting screw mandrel to rotate, drive needle stand linearly guide rail moves downward, the lower support bar be now connected with needle stand runs to bottom, and cleaning mixing bearing assembly is drawn close to reaction tray and closed the magnetic bead reaction cup to be cleaned of clamping in reactive tank corresponding with it gradually.Meanwhile, the hour hand be connected by pin cutting ferrule with needle stand is also just in time positioned at directly over magnetic bead reaction tube to be cleaned, and hour hand is connected with the soda liquor container of outside by flexible pipe, provides power that cleaning fluid is injected magnetic bead reaction cup by liquid pump.
3rd step, mixing electric motor starting, large synchronous pulley is driven to rotate by Timing Belt, then drive the cleaning be connected with large synchronous pulley to mix shaft assembly to rotate, clamped because now magnetic bead reaction cup to be cleaned cleans can not move with mixing bearing assembly, therefore cleaning mixing shaft assembly fast rotational can rub and drive magnetic bead reaction cup fast rotational to be cleaned, completes the mixing of cleaning fluid.
4th step, after having mixed, mixing motor stops, vertical-lifting Electric Machine Control vertical-lifting screw mandrel rotates, needle stand linearly guide rail continues to move downward and finally ensures that the minute hand needle point on needle stand touches at the bottom of reaction cup, by being siphoned away by cleaning waste liquid with the pump that minute hand is connected by flexible pipe, complete the cleaning step of magnetic bead reaction tube.
5th step, lower supporting rod upwards runs under vertical-lifting Electric Machine Control, and when running to top, the projection of lower supporting rod bottom makes cleaning mix bearing assembly away from reaction tray, decontrols the reaction cup after cleaning simultaneously.Mixing electric motor starting, the reaction tray in each drive rotating disk rotates a reaction cup position, until the reaction cup after cleaning to be rotated the position to corresponding substrate mixing operate portions.
6th step, controls substrate by lower supporting rod and mixes bearing assembly and to draw close to reaction tray and to clamp reaction cup, then inject substrate.Open mixing motor, now Timing Belt drives small synchronous pulley to rotate, be installed together with small synchronous pulley that the large gear turn the small gear rotates, pinion wheel drives substrate mixing shaft assembly to rotate, friction is relied on to drive reaction cup fast rotational, now due to the engagement of large pinion wheel, the rotational speed of substrate mixing shaft assembly is 2 times of cleaning mixing shaft assembly speed, meets the requirement that substrate mixes fast.After substrate has mixed, vertical-lifting electric motor starting, needle stand drives lower supporting rod to move upward, and make substrate mixing bearing assembly away from reaction tray and decontrol reaction cup, reaction cup can complete follow-up chemiluminescence immune assay work.
Wherein, described mixing shaft assembly comprises RUBBER O type pipe and mixing axle.RUBBER O type pipe box, on mixing axle, due to the protection of RUBBER O type pipe, is avoided producing cut equivalent damage to the outside surface of reaction cup in friction revolving reaction cup process.
Wherein, mixing portion also comprises spacing ring, and described spacing ring is fixed in outer disk, and spacing ring serves the upper limit effect in reaction cup blending process.
In addition; mentioned minute hand above or hour hand needs to be connected with external pump by flexible pipe; in equipment in the past, not to the equipment that connecting hose is protected, because existing equipment system is huge; pipeline is more; be easy in operating process cause coming off of flexible pipe to damage, this equipment is provided with rubber drum on rotating disk inner disc, is exclusively used in protection flexible pipe; avoid its damage that comes off, ensure that cleaning process is smooth and easy.
Above an embodiment of the invention has been described in detail, but described content being only the preferred embodiment of the invention, the practical range for limiting the invention can not being considered to.All equalization changes done according to the invention application range with improve, within the patent covering scope that still all should belong to the invention.
Claims (6)
1. a chemiluminescence immune assay evenly mixing device, comprise chassis, cleaning part, mixing portion and rotating disk, vertical-lifting driven by motor vertical-lifting screw mandrel in cleaning part rotates, then drive be positioned at vertical-lifting screw mandrel top needle stand linearly guide rail move up and down, minute hand and hour hand are fixed on needle stand by pin cutting ferrule; It is characterized in that: mixing portion is by mixing Electric Machine Control, and mixing motor is opened and driven Timing Belt to rotate, and drives mixing shaft assembly to rotate by synchrodrive; The top of lower supporting rod is connected with needle stand, and mixing bearing assembly is positioned in the outer disk of rotating disk, can realize under the control of lower supporting rod in rotating disk reaction tray draw close or away from and reaction cup is clamped or unclamps.
2. a kind of chemiluminescence immune assay evenly mixing device according to claim 1, it is characterized in that: described mixing shaft assembly comprises cleaning mixing shaft assembly and substrate mixing shaft assembly, described cleaning mixing shaft assembly drives large synchronous pulley by Timing Belt and rotates, described substrate mixing shaft assembly drives small synchronous pulley by Timing Belt, then realizes rotating by driving with small synchronous pulley meshed gears.
3. a kind of chemiluminescence immune assay evenly mixing device according to claim 2, is characterized in that: described mixing shaft assembly comprises RUBBER O type pipe and mixing axle; RUBBER O type pipe box is on mixing axle.
4. a kind of chemiluminescence immune assay evenly mixing device according to claim 3, it is characterized in that: described mixing portion also comprises spacing ring, and described spacing ring is fixed in rotating disk outer disk, and the difference in height between reaction tray is not less than the vertical height of reaction cup.
5. a kind of chemiluminescence immune assay evenly mixing device according to claim 4, it is characterized in that: described rotating disk comprises inner disc, outer disk, reaction tray, magnet groove and pipe bucket, mixing motor is connected with reaction tray center, drives reaction tray to rotate by meshed transmission gear; Outer disk is connected with reaction tray by bearing with inner disc; Outer disk is provided with magnet groove, magnet groove is built-in with magnet; Reaction tray is provided with reaction cup groove; Inner disc is provided with pipe bucket.
6. a kind of chemiluminescence immune assay evenly mixing device according to claim 5, is characterized in that: described minute hand is consistent with hour hand quantity, and described pipe bucket is equidistant to be positioned on inner disc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420576122.0U CN204203240U (en) | 2014-09-30 | 2014-09-30 | A kind of chemiluminescence immune assay evenly mixing device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420576122.0U CN204203240U (en) | 2014-09-30 | 2014-09-30 | A kind of chemiluminescence immune assay evenly mixing device |
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| CN204203240U true CN204203240U (en) | 2015-03-11 |
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| CN201420576122.0U Active CN204203240U (en) | 2014-09-30 | 2014-09-30 | A kind of chemiluminescence immune assay evenly mixing device |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104237545A (en) * | 2014-09-30 | 2014-12-24 | 博奥赛斯（天津）生物科技有限公司 | Chemiluminescent immune assay blending device |
| CN114733409A (en) * | 2022-06-09 | 2022-07-12 | 江西省金洹医疗器械股份有限公司 | Medicine detection device |
-
2014
- 2014-09-30 CN CN201420576122.0U patent/CN204203240U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104237545A (en) * | 2014-09-30 | 2014-12-24 | 博奥赛斯（天津）生物科技有限公司 | Chemiluminescent immune assay blending device |
| CN114733409A (en) * | 2022-06-09 | 2022-07-12 | 江西省金洹医疗器械股份有限公司 | Medicine detection device |
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Address after: 300300 building 14, international medical device Industrial Park, No. 16, Wujing Road, economic and Technological Development Zone, Dongli District, Tianjin Patentee after: Tianjin boasaisi Biotechnology Co.,Ltd. Address before: 300300 No. 10, Siwei Road, development zone, Dongli District, Tianjin Patentee before: BIOSCIENCE (TIANJIN) DIAGNOSTIC TECHNOLOGY Co.,Ltd. |