CN209797824U - Automatic purification system - Google Patents
Automatic purification system Download PDFInfo
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- CN209797824U CN209797824U CN201920027508.9U CN201920027508U CN209797824U CN 209797824 U CN209797824 U CN 209797824U CN 201920027508 U CN201920027508 U CN 201920027508U CN 209797824 U CN209797824 U CN 209797824U
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Abstract
Automatic purification system, including cleaning system, advance kind hydraulic system and purification system, cleaning system and advance kind hydraulic system and be connected with purification system respectively, purification system includes the sampling valve, purification subassembly and appearance valve, advance kind hydraulic system and sampling valve connection, the sampling valve is connected with the purification subassembly, the purification subassembly is connected with the appearance valve, cleaning system is connected with the purification subassembly, when equipment is started, it can wash equipment to wash purification subassembly system, prevent to take place mutual pollution between the purification liquid of remaining purification liquid in the equipment and required purification, the purity of purification thing is improved, through automatic cleaning, the cleaning efficiency of this equipment is improved, and the production efficiency is improved.
Description
Technical Field
The utility model relates to an automatic purification system.
Background
The separation of the purification component is a physical separation method designed according to the difference of the form, size and charge of the protein, which is a stationary phase and a mobile phase, when the mobile phase passes through the stationary phase filled with bead or matrix material, the physicochemical properties of the components in the mixture are such that the components are separated by repeated distribution between the two phases, while the flow of the mobile phase depends on the gravitation and pressure, and the protein in a non-denatured, natural state can be purified by chromatography.
At present, the automatic purification system on the market has a complex structure, and because the related devices are more and each device needs to be operated independently, the whole operation process needs multiple persons to nurse and control, the operation is complex, the automatic purification system is not beneficial to efficient production, and the automatic purification system does not have the function of automatic cleaning, and the production efficiency is lower.
Disclosure of Invention
Not enough more than to, the utility model aims to solve the technical problem that an automatic purification system is provided, can wash the chromatography column in the purification system automatically, improve purification efficiency.
In order to solve the technical problems, the utility model adopts the technical proposal that,
The automatic purification system comprises a cleaning system, a sample introduction hydraulic system and a purification system, wherein the cleaning system and the sample introduction hydraulic system are respectively connected with the purification system, the purification system comprises a sample introduction valve, a purification assembly and a sample outlet valve, the sample introduction hydraulic system is connected with the sample introduction valve, the sample introduction valve is connected with the purification assembly, the purification assembly is connected with the sample outlet valve, and the cleaning system is connected with the purification assembly.
When adopting above technical scheme, the utility model discloses still further adopt or make up and adopted following technical scheme.
The purification component comprises a flow direction switching valve, a cleaning valve and a chromatographic column, wherein two ends of the chromatographic column are connected with the flow direction switching valve, and the cleaning valve is respectively connected with the flow direction switching valve and a cleaning system.
The cleaning valve is a two-position four-way reversing valve, and a waste liquid collecting device is connected to the cleaning valve.
At least two purification components are arranged in the purification system, and each purification component is respectively connected with a sample injection valve and a sample outlet valve.
The sample injection valve comprises an input end and at least two output ends, the input end is connected with the sample injection hydraulic system, and the output ends are respectively connected with the purification assembly.
The sample injection valve is a six-position seven-way reversing valve.
The sample outlet valve comprises a sample outlet valve output end and at least two sample outlet valve input ends, the sample outlet valve input ends are connected with the purification assembly, and the sample outlet valve output ends are connected with sample outlets.
The sampling valve is a six-position seven-way reversing valve.
The cleaning system comprises a buffer solution switching valve, a cleaning pump and a first buffer solution container, the first buffer solution container is connected with the buffer solution switching valve, the buffer solution switching valve is connected with the cleaning pump, and the cleaning pump is connected with the purification system.
The cleaning pump is a peristaltic pump, and the buffer solution switching valve is a five-position six-way reversing valve.
The sample injection hydraulic system comprises a sample injection switching valve, a second buffer solution container, a buffer solution pump, a sample injection port, a plunger pump, a first buffer solution switching valve and a third buffer solution container, the second buffer solution container and the third buffer solution container are both connected with the first buffer solution switching valve, the first buffer solution switching valve is connected with the sample injection switching valve, the buffer solution pump is connected between the first buffer solution switching valve and the sample injection switching valve, the sample injection port is connected with the sample injection switching valve, one end of the plunger pump is connected with the sample injection switching valve, and the other end of the plunger pump is connected with a purification system.
The beneficial effects of the utility model are that, when equipment was started, wasing purification subassembly system and can wasing equipment, prevent to take place mutual pollution in the equipment between remaining purification liquid and the purification liquid of required purification, the purity of purification thing is improved, through automatic washing, improves the cleaning efficiency of this equipment, improves production efficiency.
Drawings
Fig. 1 is a schematic view of a cleaning system.
Fig. 2 is a schematic structural diagram of a sample injection hydraulic system.
FIG. 3 is a schematic diagram of the structure of the purification system.
Reference numerals: the sample injection system comprises a sample injection hydraulic system A, a purification system B, a cleaning system C, a sample injection valve 10, a purification assembly 11, a sample outlet valve 12, a flow direction switching valve 13, a cleaning valve 14, a chromatographic column 15, a waste liquid collecting device 17, an input end 19, an output end 20, a sample outlet valve output end 21, a sample outlet valve input end 22, a buffer solution switching valve 23, a cleaning pump 24, a first buffer solution container 25, a sample injection switching valve 26, a second buffer solution container 27, a buffer solution pump 28, a sample injection port 29, a plunger pump 30, a first buffer solution switching valve 31, a third buffer solution container 32 and a bubble detector 33.
Detailed Description
The present invention will be further described with reference to the accompanying drawings.
Automatic purification system, including cleaning system C, advance a kind hydraulic system A and purification system B, cleaning system C and advance a kind hydraulic system A and be connected with purification system B respectively, purification system B includes injection valve 10, purification subassembly 11 and play appearance valve 12, advance a kind hydraulic system A and be connected with injection valve 10, injection valve 10 is connected with purification subassembly 11, purification subassembly 11 is connected with play appearance valve 12, cleaning system C is connected with purification subassembly 11, when equipment is started, it can wash equipment to wash purification subassembly system, prevent to take place mutual contamination between the purification liquid of remaining purification liquid in the equipment and the purification liquid of required purification, the purity of purification thing is improved, through the automatic cleaning, improve the cleaning efficiency of this equipment, and the production efficiency is improved.
The purification assembly 11 comprises a flow direction switching valve 13, a cleaning valve 14 and a purification assembly 15, wherein both ends of the purification assembly 15 are connected with the flow direction switching valve 13, and the cleaning valve 14 is respectively connected with the flow direction switching valve 13 and the cleaning system C.
In some preferred modes, the flow direction switching valve 13 is a two-position six-way reversing valve, and the two-position six-way reversing valve can realize mutual switching between the automatic cleaning function and the sample purification function of each purification assembly 11, so that the automation degree is improved, and the operation difficulty of workers is reduced.
The cleaning valve 14 is a two-position four-way reversing valve, a waste liquid collecting device 17 is further connected to the cleaning valve 14, and waste liquid is collected through the waste liquid collecting device 17.
At least two purification components 11 are arranged in the purification system B, and each purification component 11 is respectively connected with a sample injection valve 10 and a sample outlet valve 12.
The sample injection valve comprises an input end 19 and at least two output ends 20, the input end 19 is connected with the sample injection hydraulic system A, and the output ends 20 are respectively connected with the purification assembly 11.
In some preferred modes, the sample injection valve 10 is a six-position seven-way reversing valve.
The sample valve 12 comprises a sample valve output 21 and at least two sample valve inputs 22, the sample valve inputs 22 are connected to the purification module 11, and the sample valve outputs 21 are connected to the sample valve 12.
In some preferred forms, the sample valve 12 is a six-position, seven-way diverter valve.
The washing system C includes a buffer switching valve 23, a washing pump 24, and a first buffer container 25, the first buffer container 25 is connected to the buffer switching valve 23, the buffer switching valve 23 is connected to the washing pump 24, and the washing pump 24 is connected to the purification system B.
In some preferred embodiments, the washing pump 24 is a peristaltic pump, the buffer switching valve 23 is a five-position six-way reversing valve, the buffer switching valve 23 includes five buffer inputs and one buffer output, the buffer inputs are connected to the first buffer containers 25, correspondingly, the number of the first buffer containers 25 is also five, and the buffer outputs are connected to the washing pump 24, preferably, the first buffer containers 25 are filled with buffer.
The sample injection hydraulic system A comprises a sample injection switching valve 26, a second buffer solution container 27, a buffer solution pump 28, a sample injection port 29, a plunger pump 30, a first buffer solution switching valve 31 and a third buffer solution container 32, wherein the second buffer solution container 27 and the third buffer solution container 32 are both connected with the first buffer solution switching valve 31, the first buffer solution switching valve 31 is connected with the sample injection switching valve 26, the buffer solution pump 28 is connected between the first buffer solution switching valve 31 and the sample injection switching valve 26, the sample injection port 29 is connected with the sample injection switching valve 26, one end of the plunger pump 30 is connected with the sample injection switching valve 26, and the other end of the plunger pump 30 is connected with the purification system B.
In some preferred modes, a bubble detector 33 is arranged in the sample inlet 29, and the bubble detector 31 is used for detecting the sample liquid, so that excessive bubbles in the sample liquid are prevented, and the bubbles are accumulated in the system to influence the purification effect.
the previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention; thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Although the terms corresponding to the reference numerals in the figures are used more herein, the possibility of using other terms is not excluded; these terms are used merely to more conveniently describe and explain the nature of the present invention; they are to be construed in a manner that is inconsistent with the spirit of the invention.
Claims (10)
1. Automatic purification system, a serial communication port, including cleaning system (C), advance kind hydraulic system (A) and purification system (B), cleaning system (C) and advance kind hydraulic system (A) and be connected with purification system (B) respectively, purification system (B) is including injection valve (10), purification subassembly (11) and play appearance valve (12), it is connected with injection valve (10) to advance kind hydraulic system (A), injection valve (10) are connected with purification subassembly (11), purification subassembly (11) are connected with play appearance valve (12), cleaning system (C) is connected with purification subassembly (11).
2. The automatic purification system according to claim 1, wherein the purification module (11) comprises a flow direction switching valve (13), a purge valve (14) and a chromatography column (15), both ends of the chromatography column (15) are connected to the flow direction switching valve (13), and the purge valve (14) is connected to the flow direction switching valve (13) and the purge system (C), respectively.
3. The automatic purification system according to claim 2, wherein the purge valve (14) is a two-position four-way reversing valve, and a waste liquid collecting device (17) is further connected to the purge valve (14).
4. The automated purification system according to claim 2, wherein at least two purification modules (11) are provided within the purification system (B), each purification module (11) being connected to a sample inlet valve (10) and a sample outlet valve (12), respectively.
5. The automatic purification system according to claim 1, wherein the injection valve (10) comprises one input (19) and at least two outputs (20), the input (19) being connected to the injection hydraulic system (a) and the outputs (20) being connected to the purification module (11), respectively.
6. The automated purification system according to claim 1, wherein the sample valve (12) comprises a sample valve output (21) and at least two sample valve inputs (22), the sample valve inputs (22) being connected to the purification module (11), the sample valve outputs (21) being connected to the sample valve (12).
7. The automatic purification system of claim 5 or 6, wherein the sample inlet valve (10) and the sample outlet valve (12) are both six-position seven-way reversing valves.
8. The automated purification system according to claim 1, wherein the washing system (C) comprises a buffer switching valve (23), a washing pump (24) and a first buffer container (25), the first buffer container (25) is connected to the buffer switching valve (23), the buffer switching valve (23) is connected to the washing pump (24), and the washing pump (24) is connected to the purification system (B).
9. The automated purification system of claim 8, wherein the wash pump (24) is a peristaltic pump and the buffer switching valve (23) is a five-position, six-way reversing valve.
10. The automatic purification system according to claim 1, wherein the sample hydraulic system (A) comprises a sample switching valve (26), a second buffer container (27), a buffer pump (28), a sample inlet (29), a plunger pump (30), a first buffer switching valve (31) and a third buffer container (32), the second buffer container (27) and the third buffer container (32) are both connected to the first buffer switching valve (31), the first buffer switching valve (31) is connected to the sample switching valve (26), the buffer pump (28) is connected between the first buffer switching valve (31) and the sample switching valve (26), the sample inlet (29) is connected to the sample switching valve (26), one end of the plunger pump (30) is connected to the sample switching valve (26), and the other end of the plunger pump (30) is connected to the purification system (B).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920027508.9U CN209797824U (en) | 2019-01-08 | 2019-01-08 | Automatic purification system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920027508.9U CN209797824U (en) | 2019-01-08 | 2019-01-08 | Automatic purification system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN209797824U true CN209797824U (en) | 2019-12-17 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201920027508.9U Active CN209797824U (en) | 2019-01-08 | 2019-01-08 | Automatic purification system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN209797824U (en) |
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2019
- 2019-01-08 CN CN201920027508.9U patent/CN209797824U/en active Active
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