CN201030247Y - Sequential type simulation moving bed chromatogram device - Google Patents
Sequential type simulation moving bed chromatogram device Download PDFInfo
- Publication number
- CN201030247Y CN201030247Y CNU2007201411393U CN200720141139U CN201030247Y CN 201030247 Y CN201030247 Y CN 201030247Y CN U2007201411393 U CNU2007201411393 U CN U2007201411393U CN 200720141139 U CN200720141139 U CN 200720141139U CN 201030247 Y CN201030247 Y CN 201030247Y
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- chromatographic column
- pipe
- valve
- interface
- moving bed
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Abstract
The utility mode discloses a sequential analogue moving bed chromatogram device, which comprises a feeding pipe, a cleaning solvent pipe, a raffinate pipe, a residual liquid pipe and a chromatographic column. The amount of the chromatographic column is an even number which is not less than four, the top end of the chromatographic column is connected with the feeding pipe in parallel via a valve, the side face of the upper portion of the chromatographic column is connected with the cleaning solvent pipe via a three-way member and a valve, and the lower end of the chromatographic column employs a four-way member to connected with the residual liquid pipe and the raffinate pipe which are respectively provided with valves. The other interface of the four-way member is connected with the lower interface of the three-way member of another chromatographic column, and the lower interface of the three-way member of a first chromatographic column is connected with the interface of the four-way member of a last chromatographic column. A circulating pump is arranged between the two interfaces and is then connected with a conduit in parallel which is provided with a valve. The utility model has the advantages that the concentration of the production separation is high and the operation cost is low.
Description
Technical field
The utility model relates to and utilizes adsorbent that material is carried out the purification technique field, a kind of specifically sequential simulated moving bed chromatogram arrangement.
Background technology
Simulation moving-bed is a kind of modernized separation equipment, it combines with suitable adsorption separating agent, can separate efficiently, at an easy rate manyly to be difficult to the materials that separate with conventional method, thereby since coming out from the sixties in last century, very fast at chemical industry, industries such as food are applied.Existing simulation moving-bed, mainly by rotary valve, multistage cylinder is formed, usually adopt 32 posts, 24 posts etc., but the rotary valve complex structure, sealing problem is difficult to resolve always determines, the use cost height, cylinder is more, the inconsistent unstable product quality that causes easily of the performance of each cylinder.
Summary of the invention
The purpose of this utility model is for providing a kind of good separating effect, the sequential simulated moving bed chromatogram arrangement that purity is high.
The technical scheme that realizes the foregoing invention purpose is as follows:
Sequential simulated moving bed chromatogram arrangement, comprise feed pipe, lotion pipeline, the extract pipe, residual liquid pipe and chromatographic column, wherein chromatographic column is 4 pole structures, the chromatographic column top is connected in parallel in feed pipe via a valve, the upper side of chromatographic column is connected in lotion pipeline via a threeway and a valve, the chromatographic column lower end is connected with the extract pipe with the raffinate pipe by a four-way, and be respectively equipped with valve, and another interface of four-way is connected with the following end interface of the threeway of next chromatographic column, end interface is connected with the four-way interface of last chromatographic column under the threeway of first chromatographic column, and be provided with circulating pump between two interfaces, it is in parallel that circulating pump and is provided with the pipeline of valve.
During work, eluent enters first chromatographic column, follows the ring direction and flows, and feed liquid enters the 3rd chromatographic column, and extract is drawn by the lower end of first chromatographic column, and residual liquid is drawn by the lower end of the 3rd chromatographic column.During second program, eluent enters the 3rd each and every one chromatographic column, follows the ring direction and flows, and feed liquid enters second chromatographic column, and extract is drawn by the lower end of the 3rd chromatographic column, and residual liquid is drawn by the lower end of the 4th chromatographic column.The circulation of so postponing.
The utlity model has following advantage:
1. product separates the concentration height;
2. the low advantage of use cost;
3. compact conformation;
4. low cost of manufacture;
5. reduced too much structure, moved more reliable.
Description of drawings
Fig. 1 is the structural representation of the utility model embodiment
The specific embodiment
The utility model is described in further detail below in conjunction with the drawings and specific embodiments.
As shown in Figure 1, sequential simulated moving bed with four posts is example, sequential simulated moving bed chromatogram arrangement, comprise feed pipe, lotion pipeline, the extract pipe, residual liquid pipe and chromatographic column, wherein chromatographic column is 4, be respectively A, B, C, D, its top is connected with feed pipe, and respectively by valve control charging aperture A2, B2, C2, D2, the upper side of chromatographic column is connected in lotion pipeline via a threeway, and respectively by valve control washing lotion import A1, B1, C1, D1, the chromatographic column lower end is connected with the extract pipe with the raffinate pipe by a four-way, and be respectively equipped with valve, control extract outlet A3, B3, C3, D3 and raffinate outlet A4, B4, C4, D4, and another interface of four-way is connected with the following end interface of the threeway of next chromatographic column, and end interface is connected with the four-way interface of chromatographic column D under the threeway of chromatographic column A, and be provided with circulating pump F between above-mentioned two interfaces, it is in parallel that circulating pump F and is provided with the pipeline of valve E3.
In first program, eluent enters post A by A1, follows the ring direction and flows, and feed liquid enters post C from C2, and extract and residual liquid are drawn by A3 and C4 respectively.Like this, post A is an elution zone, and post B, C are adsorptive separation zone, and post D is the district that concentrates.During second program, charging aperture moves to B2, and eluant, eluent is entered by C1, and liquid outlet becomes D3 and B4, the circulation of so postponing.Process variations matched with the speed of passing forward under the eluent effect between two kinds of component mixed zones in the post in the time, in other words, made in the pipe feed liquid form close part with feed liquid as far as possible in the mixed zone.
Claims (2)
1. sequential simulated moving bed chromatogram arrangement, comprise feed pipe, lotion pipeline, the extract pipe, residual liquid pipe and chromatographic column, it is characterized by wherein, chromatographic column is to be not less than 4 even number, the chromatographic column top is connected in parallel in feed pipe via a valve, the upper side of chromatographic column is connected in lotion pipeline via a threeway and a valve, the chromatographic column lower end is connected with the extract pipe with the raffinate pipe by a four-way, and be respectively equipped with valve, and another interface of four-way is connected with the following end interface of the threeway of next chromatographic column, end interface is connected with the four-way interface of last chromatographic column under the threeway of first chromatographic column, and be provided with circulating pump between two interfaces, it is in parallel that circulating pump and is provided with the pipeline of valve.
2. sequential simulated moving bed chromatogram arrangement according to claim 1, the number that it is characterized by described chromatographic column are 4-24 even number.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2007201411393U CN201030247Y (en) | 2007-03-27 | 2007-03-27 | Sequential type simulation moving bed chromatogram device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2007201411393U CN201030247Y (en) | 2007-03-27 | 2007-03-27 | Sequential type simulation moving bed chromatogram device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201030247Y true CN201030247Y (en) | 2008-03-05 |
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ID=39162141
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNU2007201411393U Expired - Fee Related CN201030247Y (en) | 2007-03-27 | 2007-03-27 | Sequential type simulation moving bed chromatogram device |
Country Status (1)
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| CN (1) | CN201030247Y (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101940850A (en) * | 2010-09-29 | 2011-01-12 | 西安航天华威化工生物工程有限公司 | Sequential simulated moving bed |
| CN101972558A (en) * | 2010-11-30 | 2011-02-16 | 顾雄毅 | Expanded bed chromatographic separation column used for biochemical separation process and process flow |
| WO2012072029A1 (en) * | 2010-11-30 | 2012-06-07 | Gu Xiongyi | Expanded bed chromatographic separation column for biochemical separation process and technical process thereof |
| CN103007576A (en) * | 2012-12-11 | 2013-04-03 | 聊城万合工业制造有限公司 | Crude drug continuous purifying and extracting system |
| CN104667575A (en) * | 2014-09-25 | 2015-06-03 | 宁波拓谱生物科技有限公司 | Intelligent ultrahigh-pressure micro simulation moving bed chromatographic instrument |
-
2007
- 2007-03-27 CN CNU2007201411393U patent/CN201030247Y/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101940850A (en) * | 2010-09-29 | 2011-01-12 | 西安航天华威化工生物工程有限公司 | Sequential simulated moving bed |
| CN101940850B (en) * | 2010-09-29 | 2012-08-29 | 西安航天华威化工生物工程有限公司 | Sequential simulated moving bed |
| CN101972558A (en) * | 2010-11-30 | 2011-02-16 | 顾雄毅 | Expanded bed chromatographic separation column used for biochemical separation process and process flow |
| WO2012072029A1 (en) * | 2010-11-30 | 2012-06-07 | Gu Xiongyi | Expanded bed chromatographic separation column for biochemical separation process and technical process thereof |
| CN101972558B (en) * | 2010-11-30 | 2013-01-02 | 顾雄毅 | Expanded bed chromatographic separation column used for biochemical separation process and process flow |
| CN103007576A (en) * | 2012-12-11 | 2013-04-03 | 聊城万合工业制造有限公司 | Crude drug continuous purifying and extracting system |
| CN104667575A (en) * | 2014-09-25 | 2015-06-03 | 宁波拓谱生物科技有限公司 | Intelligent ultrahigh-pressure micro simulation moving bed chromatographic instrument |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20080305 |