CN101940850B - Sequential simulated moving bed - Google Patents
Sequential simulated moving bed Download PDFInfo
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- CN101940850B CN101940850B CN2010102954815A CN201010295481A CN101940850B CN 101940850 B CN101940850 B CN 101940850B CN 2010102954815 A CN2010102954815 A CN 2010102954815A CN 201010295481 A CN201010295481 A CN 201010295481A CN 101940850 B CN101940850 B CN 101940850B
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- valve
- chromatographic column
- moving bed
- columns
- simulated moving
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- 239000000463 material Substances 0.000 claims abstract description 12
- 239000007788 liquid Substances 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 52
- 238000007600 charging Methods 0.000 claims description 13
- 230000000740 bleeding effect Effects 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 6
- 238000004321 preservation Methods 0.000 claims description 3
- 230000007306 turnover Effects 0.000 claims description 3
- 238000000926 separation method Methods 0.000 abstract description 7
- 239000003814 drug Substances 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 2
- 235000013305 food Nutrition 0.000 abstract description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 239000000178 monomer Substances 0.000 abstract description 2
- 238000009825 accumulation Methods 0.000 abstract 1
- -1 biology Substances 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 239000012847 fine chemical Substances 0.000 abstract 1
- 239000003208 petroleum Substances 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 5
- 229960002737 fructose Drugs 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 229930091371 Fructose Natural products 0.000 description 4
- 239000005715 Fructose Substances 0.000 description 4
- 239000003480 eluent Substances 0.000 description 3
- 230000008676 import Effects 0.000 description 3
- GMWTXQKKRDUVQG-WOPPDYDQSA-N 4-amino-5-bromo-1-[(2r,3s,4s,5r)-4-hydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]pyrimidin-2-one Chemical compound C[C@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)N=C(N)C(Br)=C1 GMWTXQKKRDUVQG-WOPPDYDQSA-N 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
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- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
The invention relates to a sequential simulated moving bed. The simulated moving bed is mass transfer equipment which carries out liquid separation by utilizing an adsorption principle and is widely applicable to various production fields of petroleum, fine chemicals, biology, medicine, food and the like, and the existing simulated moving bed can not adopt a manual mode to open a valve and is usually of a monomer structure, namely a single moving bed of 4 columns or 6 columns, which can not switch among various working conditions. The sequential simulated moving bed utilizes circulating pumps arranged between two adjacent chromatographic columns to push materials to pass through the chromatographic columns, thus avoiding accumulation; the circulation of a raw material tank can avoid a circulation blocking phenomenon of a pipeline; from a chromatographic column III, feed ports of the chromatographic columns of odd numbers are provided with manual valves, and flexible switching among various working conditions of 4 columns, 6 columns or 8 columns can be carried out; and the valves of the chromatographic columns can be flexibly controlled by an automatic control system. The sequential simulated moving bed has the characteristics of having high automatic control degree and good separation effect and being capable of realizing flexible switching among various working conditions.
Description
Technical field
The present invention relates to the separation equipment technical field, be specifically related to a kind of sequential simulated moving bed.
Background technology
The SMBC isolation technics is a kind of modernized isolation technics that grows up the sixties in 20th century; Its range of application relates to a lot of production fields such as oil, fine chemistry industry, biology, medicine, food, especially in the separating of mixtures such as homologous compound, chiral isomer medicine, carbohydrate, organic acid and amino acid, demonstrates its special performance.At the separation field of sugar alcohol, SMBC separating levulose and glucose are the methods of current the best.The current external existing complete commercial equipment of producing ten thousand tons of fructose per year, China has just begun the research of this respect as far back as the eighties in 20th century, but so far also ability do not produce this equipment.The problem that prior art exists is: existing simulation moving-bed, still adopt the manual mode Open valve, and can't move automatically; And be generally monomer structure, 4 promptly single post moving beds, 6 post moving beds or the like, if process reform need be bought moving bed again, cost is bigger.
Summary of the invention
The purpose of this invention is to provide higher sequential simulated moving bed of a kind of automaticity, can not move automatically to solve the equipment that exists in the existing separation equipment technical field, problem that can't switching working mode.
The technical scheme that the present invention adopts is:
Sequential simulated moving bed; Include chromatographic column, material turnover system, wash water jar, head tank, wash water filter, raw material filter, feedstock pump, wash water pump, flowmeter, extraction flow container, raffinate jar, automatic control system, it is characterized in that: be provided with circulating pump between the two adjacent root chromatogram columns; Since the 3rd root chromatogram column, the charging aperture of the chromatographic column of odd positions is provided with hand-operated valve; Circulating pump is connected with automatic control system.
Described every root chromatogram column upper end is provided with inlet valve, water intaking valve and air bleeding valve, and the lower end is provided with sample valve, raffinate outlet valve, extracting liquid outlet valve and circulation pneumatic operated valve; Described inlet valve, water intaking valve, air bleeding valve, sample valve, raffinate outlet valve, extracting liquid outlet valve and circulation pneumatic operated valve all are connected with automatic control system.
On total pipeline that described wash water jar is connected with chromatographic column branch is set, and is connected, valve is set in the branch with self; On total pipeline that head tank is connected with chromatographic column branch is set, and is connected, valve is set in the branch with self.
Described chromatographic column is arranged in the preservation and controlling case.
The present invention has the following advantages:
The present invention has installed circulating pump in the middle of adjacent two root chromatogram columns, through the promotion of circulating pump, material can be avoided piling up smoothly through the fixedly phase in the chromatographic column; Secondly, when the purification material, have two chromatographic columns and be in idle state, can avoid the circulation of material not smooth through the cyclic design that adds pump this moment; Head tank through self circulation of feedstock pump, can be avoided the circulation clogging of pipeline when charging not; Begin from the III chromatographic column, the charging aperture of the chromatographic column of odd positions is provided with hand-operated valve, can under various working such as 4 posts, 6 posts, 8 posts, switch flexibly, and avoiding needs the problem of repetition purchase of equipment because the equipment of technological requirement is different; And can control the valve of chromatographic column flexibly through automatic control system.
Description of drawings
Fig. 1 is a structural representation of the present invention.
Fig. 2 is an I chromatographic column structure sketch map.
Among the figure, 1-wash water jar, 2-head tank, 3-wash water filter, 4-raw material filter, 5-feedstock pump; 6-wash water pump, 7-flowmeter, 8-I chromatographic column, 9-II chromatographic column, 10-III chromatographic column, 11-IV chromatographic column; 12-V chromatographic column, 13-VI chromatographic column, 14-VII chromatographic column, 15-VIII chromatographic column, 16-V post hand-operated valve, 17-VII post hand-operated valve; 18-I circulating pump, 19-II circulating pump, 20-III circulating pump, 21-IV circulating pump, 22-extracts flow container, 23-raffinate jar;
The 24-inlet valve, 25-water intaking valve, 26-extracting liquid outlet valve, 27-raffinate outlet valve, 28-circulation pneumatic operated valve, 29-air bleeding valve, 30-sample valve.
The specific embodiment
Below in conjunction with accompanying drawing and specific embodiment the present invention is described in detail.
Of the present invention sequential simulated moving bed, include 8 root chromatogram columns, material turnover system, wash water jar 1, head tank 2, wash water filter 3, raw material filter 4, feedstock pump 5, wash water pump 6, flowmeter 7, extract flow container 22, raffinate jar 23, automatic control system.Wash water jar 1 is connected with each chromatogram capital end through back with water inlet line, and wash water filter 3 and wash water pump 6 are housed on the pipeline, on total pipeline that wash water jar 1 is connected with chromatographic column branch is set, and is connected with self, and valve is set in the branch; The purpose of design is like this, makes wash water jar 1 realize self circulation.Equally, head tank 2 is connected with each chromatogram capital end through feeding line, and raw material filter 4 and feedstock pump 5 are housed on the pipeline, on total pipeline that head tank 2 is connected with chromatographic column branch is set, and is connected with self, and valve is set in the branch; The purpose of design is like this, makes head tank 2 when charging not, can realize that self circulates, and can effectively avoid the circulation clogging of pipeline through feedstock pump 5.
Two adjacent root chromatogram column lower ends are provided with circulating pump; I circulating pump 18 promptly is installed between I chromatographic column 8 and II chromatographic column 9; II circulating pump 19 is installed between III chromatographic column 10 and IV chromatographic column 11; III circulating pump 20 is installed between V chromatographic column 12 and VI chromatographic column 13, IV circulating pump 21 is installed between VII chromatographic column 14 and VIII chromatographic column 15; Through the promotion of circulating pump, material can be avoided piling up smoothly through the fixedly phase in the chromatographic column.Circulating pump is connected with automatic control system, realizes the automatic propelling of material.
From 10 beginnings of III chromatographic column, the charging aperture of the chromatographic column of odd positions is provided with hand-operated valve, can under various working such as 4 posts, 6 posts, 8 posts, switch flexibly.When opening V post hand-operated valve 16, be 8 root chromatogram column operating conditions with VII post hand-operated valve 17; When opening V post hand-operated valve 16, when closing VII post hand-operated valve 17, being 6 root chromatogram column operating conditions; When closing V post hand-operated valve 16, be 4 root chromatogram column operating conditions with VII post hand-operated valve 17.
Described every root chromatogram column upper end is provided with inlet valve 24, water intaking valve 25 and air bleeding valve 29, and the lower end is provided with sample valve 30, raffinate outlet valve 27, extracting liquid outlet valve 26 and circulation pneumatic operated valve 28, all is connected with automatic control system; Circulating pump also connects with automatic control system.
Chromatographic column is arranged in the preservation and controlling case, guarantees that system temperature is constant, improves the stability and the operating efficiency of separating of separating operation.
Embodiment 1:
During the operation of 8 column systems, open V post hand-operated valve 16 and VII post hand-operated valve 17.Start feedstock pump 5 and wash water pump 6, automatic controlling system I post inlet valve 24, V post water intaking valve 25, VI post extracting liquid outlet valve 26, III post raffinate outlet valve 27, I post circulation pneumatic operated valve 28, II post circulation pneumatic operated valve 28, V post circulation pneumatic operated valve 28 are opened simultaneously, and all the other valves close; I chromatographic column 8 chargings this moment, the charging flow velocity is 14L/H, II chromatographic column 9 water inlet wash-outs; Flow velocity is 13L/H, and the outlet of III chromatographic column 10 goes out raffinate, gets into raffinate jar 23; VI chromatographic column 13 exports out extract; Get into to extract flow container 22, feed time, advance eluant, eluent time 300S after, feedstock pump 5 is closed with wash water pump 6; Automatic controlling system I post circulation pneumatic operated valve 28, II post circulation pneumatic operated valve 28, III post circulation pneumatic operated valve 28, IV post circulation pneumatic operated valve 28, V post circulation pneumatic operated valve 28, VI post circulation pneumatic operated valve 28, VII post circulation pneumatic operated valve 28, VIII post circulation pneumatic operated valve 28 are opened simultaneously; All the other valves close, duration 1000S, and material component separates into one pack system in this process.After circulation finishes; Open wash water pump 6, automatic controlling system VI post water intaking valve 25, VI post circulation pneumatic operated valve 28, VII post circulation pneumatic operated valve 28, VIII post circulation pneumatic operated valve 28, I post circulation pneumatic operated valve 28, II post circulation pneumatic operated valve 28, III post circulation pneumatic operated valve 28, IV post raffinate outlet valve 28 are opened simultaneously, and all the other valves close; The import of VI chromatographic column 13 water inlet at this moment; The water inlet flow velocity is 11L/H, and III chromatographic column 10 exports out raffinate, gets into raffinate jar 22.After this element EP (end of program),, so analogize from the 9 beginning chargings of II chromatographic column, 13 water inlets of VI chromatographic column.
After this element EP (end of program),, so analogize from the 9 beginning chargings of II chromatographic column, 13 water inlets of VI chromatographic column.
Whole system is operation automatically continuously, reaches the separation purpose, and final fructose purity reaches more than 97%, and 1 liter of release agent can obtain 14g fructose in 1 hour, and separative efficiency is remarkable.
Embodiment 2:
During the operation of 4 column systems, automatic control system is closed V post hand-operated valve 16, VII post hand-operated valve 17.Start feedstock pump 5 and wash water pump 6; Automatic controlling system I post inlet valve 24, III post water intaking valve 25, III post extracting liquid outlet valve 26, I post raffinate outlet valve 27 are opened, and all the other valves close, I chromatographic column 8 chargings this moment; III chromatographic column 10 water inlet wash-outs; The outlet of I chromatographic column 8 goes out raffinate, gets into raffinate jar 23, and III chromatographic column 10 exports out extract; Get into to extract flow container 22, feed time, advance pneumatic operated valve before and after eluant, eluent time and this step switch by automatic controlling system.Then, feedstock pump 5 is closed with wash water pump 6, and automatic controlling system I post circulation pneumatic operated valve 28, II post circulation pneumatic operated valve 28, III post circulation pneumatic operated valve 28, IV post circulation pneumatic operated valve 28 are opened, and all the other valves close, and material component separates into one pack system in this process.After circulation finishes, open wash water pump 6, simultaneously; IV post water intaking valve 25, IV post circulation pneumatic operated valve 28, I post circulation pneumatic operated valve 28, II post raffinate outlet valve 28 are opened, and all the other valves close, the import of IV chromatographic column 11 water inlet at this moment; II chromatographic column 9 exports out raffinate, gets into raffinate jar 23.
After this element EP (end of program),, so analogize from the 9 beginning chargings of II chromatographic column, 11 water inlets of IV chromatographic column.
Embodiment 3:
Before the operation of 6 column systems, at first, automatic control system is opened V post hand-operated valve 16, closes VII post hand-operated valve 17, and 4 column systems are switched to 6 column systems.When system moves, at first, start feedstock pump 5 and wash water pump 6; Automatic controlling system I post inlet valve 24, V post water intaking valve 25, V post extracting liquid outlet valve 26, II post raffinate outlet valve 27, I post circulation pneumatic operated valve 28 are opened, and all the other valves close, I chromatographic column 8 chargings this moment; V chromatographic column 12 water inlet wash-outs; The outlet of II chromatographic column 9 goes out raffinate, gets into raffinate jar 23, and V chromatographic column 12 exports out extract; Get into to extract flow container 22, feed time, advance pneumatic operated valve before and after eluant, eluent time and this step switch by computer control.Then; Feedstock pump 5 is closed with wash water pump 6; Each circulating pump is opened simultaneously; I post circulation pneumatic operated valve 28, II post circulation pneumatic operated valve 28, III post circulation pneumatic operated valve 28, IV post circulation pneumatic operated valve 28, V post circulation pneumatic operated valve 28, VI post circulation pneumatic operated valve 28 are opened, and all the other valves close, and material component separates into one pack system in this process.After circulation finishes; Open wash water pump 6, simultaneously, VI post water intaking valve 25, VI post circulation pneumatic operated valve 28, I post circulation pneumatic operated valve 28, II post circulation pneumatic operated valve 28, III post raffinate outlet valve 28 are opened; All the other valves close; The import of VI chromatographic column 13 water inlet at this moment, III chromatographic column 10 exports out raffinate, gets into raffinate jar 23.
The package unit technological design is reasonable, and system is stable, and is simple to operate, and good separating effect is fit to industrial separation fructose.Simultaneously, through the switch switching of hand-operated valve, realize that the operating mode between 8 column systems, 6 column systems, 4 column systems is switched; Through changing release agent, can separate blending ingredients more how of different nature, be applied to other field.
Claims (3)
1. sequential simulated moving bed; Include chromatographic column, material turnover system, wash water jar (1), head tank (2), wash water filter (3), raw material filter (4), feedstock pump (5), wash water pump (6), flowmeter (7), extract flow container (22), raffinate jar (23), automatic control system, it is characterized in that: be provided with circulating pump between the two adjacent root chromatogram columns; Since the 3rd root chromatogram column, the charging aperture of the chromatographic column of odd positions is provided with hand-operated valve; Circulating pump is connected with automatic control system;
On total pipeline that wash water jar (1) is connected with chromatographic column branch is set, this branch is connected with wash water jar (1), in this branch valve is set; On total pipeline that head tank (2) is connected with chromatographic column branch is set, this branch is connected with head tank (2), in this branch valve is set.
2. according to claim 1 sequential simulated moving bed; It is characterized in that: every root chromatogram column upper end is provided with inlet valve (24), water intaking valve (25) and air bleeding valve (29), and the lower end is provided with sample valve (30), raffinate outlet valve (27), extracting liquid outlet valve (26) and circulation pneumatic operated valve (28); Described inlet valve (24), water intaking valve (25), air bleeding valve (29), sample valve (30), raffinate outlet valve (27), extracting liquid outlet valve (26) and circulation pneumatic operated valve (28) all are connected with automatic control system.
3. according to claim 1 sequential simulated moving bed, it is characterized in that: described chromatographic column is arranged in the preservation and controlling case.
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| CN2010102954815A CN101940850B (en) | 2010-09-29 | 2010-09-29 | Sequential simulated moving bed |
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| CN2010102954815A CN101940850B (en) | 2010-09-29 | 2010-09-29 | Sequential simulated moving bed |
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| CN101940850A CN101940850A (en) | 2011-01-12 |
| CN101940850B true CN101940850B (en) | 2012-08-29 |
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| CN107954425A (en) * | 2017-11-29 | 2018-04-24 | 西安航天华威化工生物工程有限公司 | Slapple activating furnace energy conserving system and its operation method |
| CN109432822B (en) | 2018-11-14 | 2023-09-29 | 内蒙古伊泰煤基新材料研究院有限公司 | Efficient simulated moving bed equipment and efficient simulated moving bed process |
| CN113893578A (en) * | 2021-09-08 | 2022-01-07 | 四川雅华生物有限公司 | Separation and purification system and process method of hydrolysate |
| CN115975067B (en) * | 2022-12-20 | 2024-05-28 | 黑龙江八一农垦大学 | Method for preparing polydextrose by taking glucose mother liquor as raw material |
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| CN1327867A (en) * | 2001-06-06 | 2001-12-26 | 浙江大学 | Analog counter-flow adsorption separator with open loop structure |
| CN1374146A (en) * | 2002-03-13 | 2002-10-16 | 浙江大学 | Analogue mobile bed chromatic reactor |
| EP1325772A1 (en) * | 2001-12-19 | 2003-07-09 | Institut Francais Du Petrole | System for injecting a by-pass fluid in a separation methof in a simulated moving bed |
| CN201030247Y (en) * | 2007-03-27 | 2008-03-05 | 温州市日中轻工机械有限公司 | Sequential type simulation moving bed chromatogram device |
| CN201076777Y (en) * | 2007-06-14 | 2008-06-25 | 山东福田药业有限公司 | Subsequent type stimulant moving bed |
| CN101732890A (en) * | 2009-12-08 | 2010-06-16 | 辽宁科技大学 | Three-section simulated moving bed chromatography device |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09206502A (en) * | 1995-12-01 | 1997-08-12 | Daicel Chem Ind Ltd | Pseudo moving bed type separator |
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2010
- 2010-09-29 CN CN2010102954815A patent/CN101940850B/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1327867A (en) * | 2001-06-06 | 2001-12-26 | 浙江大学 | Analog counter-flow adsorption separator with open loop structure |
| EP1325772A1 (en) * | 2001-12-19 | 2003-07-09 | Institut Francais Du Petrole | System for injecting a by-pass fluid in a separation methof in a simulated moving bed |
| CN1374146A (en) * | 2002-03-13 | 2002-10-16 | 浙江大学 | Analogue mobile bed chromatic reactor |
| CN201030247Y (en) * | 2007-03-27 | 2008-03-05 | 温州市日中轻工机械有限公司 | Sequential type simulation moving bed chromatogram device |
| CN201076777Y (en) * | 2007-06-14 | 2008-06-25 | 山东福田药业有限公司 | Subsequent type stimulant moving bed |
| CN101732890A (en) * | 2009-12-08 | 2010-06-16 | 辽宁科技大学 | Three-section simulated moving bed chromatography device |
Non-Patent Citations (1)
| Title |
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| JP特开平9-206502A 1997.08.12 |
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