CN203139686U - Intermittent chromatographic separation device - Google Patents
Intermittent chromatographic separation device Download PDFInfo
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- CN203139686U CN203139686U CN 201320067446 CN201320067446U CN203139686U CN 203139686 U CN203139686 U CN 203139686U CN 201320067446 CN201320067446 CN 201320067446 CN 201320067446 U CN201320067446 U CN 201320067446U CN 203139686 U CN203139686 U CN 203139686U
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Abstract
The utility model discloses an intermittent chromatographic separation device. The intermittent chromatographic separation device comprises a separation device, a raw material conveying device, an eluent conveying device and a collecting device, wherein the raw material conveying device and the eluent conveying device are respectively connected with the input end of the separation device, and the collecting device is connected with the output end of the separation device. By increasing the quantity of cycling conveying pumps and pressure sensors, the defects of a traditional continuous simulation movable bed separation system can be overcome, a novel technology of a simulation movable bed is realized through the intermittent chromatographic separation device, the technology is convenient to operate and stable to run, and each index is optimized. By adopting the intermittent chromatographic separation device, not only can the utilization rate of a separation medium be increased, but also the water consumption can be reduced, and the impacting degree on resin can be reduced.
Description
Technical field
The present invention relates to a kind of chromatographic separation technology, specifically a kind of batch (-type) chromatographic separation device and method.
Background technology
The traditional analog moving bed forms closed cycle by the series connection of many pillars (being generally the 6-12 root forms) head and the tail.As shown in Figure 1, the delivered inside (pillar quantity can adopt 2 10 when above) that a delivery pump P1 carries out feed liquid is installed in the circulation line optional position; Dispose FIC1 of flowmeter for detection of the internal system flow at pump discharge; In circulation line optional position installation quality flowmeter DIC1 detectable concentration bands of a spectrum situation of change; At delivery side of pump setting pressure sensor PT1, be used for the testing pump outlet pressure; 1 charging switch valve KS1 and a water inlet switch valve KS2 are installed in the import of each pillar; The outlet of each pillar is installed one and is gone out slow component switch valve KS3 and one and go out fast component switch valve KS4; The eluent inlet flow rate is Q2, by flowmeter FIC2 and intake pump P2 VFC, the slow component rate of discharge is Q4, by flowmeter FIC4 and control valve FCV4 control, the material liquid inlet flow rate is Q3, by flowmeter FIC3 and feed pump P3 VFC, detect slow component concentration by DIC4, the fast component rate of discharge is Q5, by flowmeter FIC5 and control valve FCV5 control, detect fast component concentration by DIC5, these 4 mouths will simulation moving-bedly be divided into 4 districts, and the district between eluent entrance and slow component export is called the Z1 district; Be the Z2 district between slow component outlet and the material liquid entrance; Be the Z3 district between material liquid entrance and the fast component outlet; Be the Z4 district between fast component outlet and the eluent entrance; In setting-up time four mouths respectively the moving phase direction of longshore current move to the correspondence position of next pillar, reaching flows moves with fixing adverse current mutually mutually.
As shown in Figure 2, the traditional analog moving bed method of operation is to move according to the parameter of setting, setup parameter comprises T cycle time, circular flow Q1, flow of inlet water Q2, slow component discharge Q4, feed rate Q3, fast component discharge Q5, in system's running, 2 flow Q2, Q3 entering system enter system by pump P2, P3 sustainable supply, and 2 kinds of dischargings are respectively by the chain control of FIC4/FCV4, FIC5/FCV5, this operational mode is continuous the entering in the system of eluting water and material liquid, and slow component and fast component are discharged continuously.Material and eluting water constantly enter system in continuous separation process, and material and eluting water constantly are dispersed in the system, and actual is that back-mixing is caused in the subregion, has taken time and the space of entire separation system, and the utilization rate of separating medium has reduced.
Because eluting water constantly disperseed, be actually used in Z4 separate from the space significantly reduced, the ability of utilizing of traditional chromatographic fractionation system inner loop water reduces, reality has increased water consumption;
Because traditional chromatographic isolation tradition circulating pump is few, after the resistance accumulation through several pillars, forms bigger pressure at pump discharge, causes higher pressure reduction, resin is caused in various degree impact.
Summary of the invention
At above-mentioned deficiency, the invention provides a kind of batch (-type) chromatographic separation device and method, it has not only improved the utilization rate of separating medium, and can reduce water consumption, has reduced the impact degree to resin.
The present invention solves the technical scheme that its technical problem takes:
The invention provides a kind of batch (-type) chromatographic separation device, comprise separator, raw material conveying device, eluant, eluent conveying device and gathering-device, described raw material conveying device is connected with the input of separator respectively with the eluant, eluent conveying device, the output of described gathering-device and separator is connected, it is characterized in that, described separator comprises some chromatographic columns, the import of described each chromatographic column and outlet all arrange a pressure sensor, each chromatographic column outlet arranges a circulation dehvery pump, one of them exit of described circulation dehvery pump is provided with flowmeter, one of them exit of described circulation dehvery pump is provided with mass flowmenter, and the import department of described each chromatographic column and exit arrange two pneumatic on-off valves respectively; Described raw material conveying device comprises material container and is arranged on control valve and pressure sensor on the feed pipe; Described eluant, eluent conveying device comprises the eluant, eluent container and is arranged on control valve and pressure sensor on the inlet channel; Described gathering-device comprises the two-way discharge pipe, and described each road discharge pipe is respectively arranged with flowmeter, mass flowmenter and control valve.
Further, described pneumatic on-off valve comprises charging pneumatic on-off valve, water inlet pneumatic on-off valve, intercolumniation pneumatic on-off valve, slow component discharging pneumatic on-off valve and fast component discharging pneumatic on-off valve, described charging pneumatic on-off valve and water inlet pneumatic on-off valve are arranged on the import department of each chromatographic column, described intercolumniation pneumatic on-off valve is arranged on the connecting pipe of each chromatographic column, and between chromatographic column import and export pneumatic on-off valve; Described slow component discharging pneumatic on-off valve and fast component discharging pneumatic on-off valve are arranged on the exit of each chromatographic column.
Further, described discharge pipe comprises slow component discharge pipe and fast component discharge pipe.
The present invention also provides a kind of batch (-type) chromatography separating method, it is characterized in that, comprises following process:
1) chromatogram systemic circulation separating process: the closed pneumatic valve on closeall chromatographic column and raw material conveying device, eluant, eluent conveying device and the gathering-device connecting line, carry out the circulation of separator internal composition, this process is labeled as the A section;
2) chromatogram partial circulating separating process: open the fast component discharging pneumatic on-off valve that water inlet pneumatic on-off valve that Z1 district chromatographic column is connected with the eluant, eluent conveying device and chromatographic column are connected with the fast component discharge pipe, open the intercolumniation pneumatic on-off valve in Z1 district, Z2 district and Z3 district simultaneously, the fast component of execution discharging equivalent when injecting eluant, eluent, this process is labeled as the B section;
3) chromatogram all-in and all-out separating process: carry out simultaneously and utilize eluant, eluent wash-out slow component process and input raw material to discharge equivalent fast component process,
The described eluant, eluent wash-out slow component process of utilizing is to open the slow component discharging pneumatic on-off valve that water inlet pneumatic on-off valve that Z1 district chromatographic column is connected with the eluant, eluent conveying device and chromatographic column are connected with the slow component discharge pipe, carries out the slow component of discharging equivalent when injecting eluant, eluent.This process is labeled as the C section,
It is to open the fast component discharging pneumatic on-off valve that charging pneumatic on-off valve that Z3 district chromatographic column is connected with raw material conveying device and chromatographic column are connected with the fast component discharge pipe that described input raw material is discharged equivalent fast component process, open the intercolumniation pneumatic on-off valve in Z3 district simultaneously, carry out the fast component of when injecting raw material, discharging equivalent.This process is labeled as the D section;
Wherein, before carrying out said process, need the relevant parameter of A, B, C, each section of D is arranged.
Preferably, described relevant parameter comprises setting flow Qa, Qb, Qc, the Qd of A, B, C, D section, and A, B, C, flow volume Va, the Vb of D section, Vc, Vd.
The invention has the beneficial effects as follows: the present invention has overcome the drawback in traditional continuous analog moving bed piece-rate system, a kind of simulation moving-bed new technology of implementation, and convenient, stable, the every index of this technological operation reaches optimization.The present invention has not only improved the utilization rate of separating medium, and can reduce water consumption, has reduced the impact degree to resin.
Description of drawings
Fig. 1 is the structural representation of traditional analog moving bed;
Fig. 2 is the process schematic representation of traditional analog moving bed;
Fig. 3 is structural representation of the present invention;
Fig. 4 is chromatogram circulation separation processes schematic diagram of the present invention;
Fig. 5 be chromatogram half point of the present invention from process schematic representation;
Fig. 6 is the full separation processes schematic diagram of chromatogram of the present invention;
Fig. 7 is that the eluant, eluent of the present invention and traditional handicraft is utilized situation contrast schematic diagram;
Fig. 8 is the feed distribution situation contrast schematic diagram of the present invention and traditional handicraft;
Fig. 9 is that the performance of the present invention and traditional handicraft compares schematic diagram;
Among the figure,
Z1-Z4 is four simulation moving-bed subregions;
KS1-KS5 is pneumatic on-off valve;
P1-P6 is circulating pump, and P7, P8 are feed pump;
SC1-SC6 is the frequency converter of circulating pump, and SC7-SC8 is the frequency converter of feed pump;
PT1-PT3 is pressure sensor;
FIC is flowmeter;
DIC1, DIC4-DIC5 are mass flowmenter;
FCV4-FCV5 is control valve.
The specific embodiment
As shown in Figure 3, a kind of batch (-type) chromatographic separation device of the present invention, it comprises separator, raw material conveying device, eluant, eluent conveying device and gathering-device, described raw material conveying device is connected with the input of separator respectively with the eluant, eluent conveying device, and the output of described gathering-device and separator is connected.Described separator comprises some chromatographic columns, the import of described each chromatographic column and outlet all arrange a pressure sensor, each chromatographic column outlet arranges a circulation dehvery pump, one of them exit of described circulation dehvery pump is provided with flowmeter, one of them exit of described circulation dehvery pump is provided with mass flowmenter, and the import department of described each chromatographic column and exit arrange two pneumatic on-off valves respectively; Described raw material conveying device comprises material container and is arranged on control valve and pressure sensor on the feed pipe; Described eluant, eluent conveying device comprises the eluant, eluent container and is arranged on control valve and pressure sensor on the inlet channel; Described gathering-device comprises the two-way discharge pipe, and described each road discharge pipe is respectively arranged with flowmeter, mass flowmenter and control valve;
Further, described pneumatic on-off valve comprises charging pneumatic on-off valve, water inlet pneumatic on-off valve, intercolumniation pneumatic on-off valve, slow component discharging pneumatic on-off valve and fast component discharging pneumatic on-off valve, described charging pneumatic on-off valve and water inlet pneumatic on-off valve are arranged on the import department of each chromatographic column, described intercolumniation pneumatic on-off valve is arranged on each chromatographic column connecting pipe, and between chromatographic column import and export pneumatic on-off valve; Described slow component discharging pneumatic on-off valve and fast component discharging pneumatic on-off valve are arranged on the exit of each chromatogram.
Further, described discharge pipe comprises slow component discharge pipe and fast component discharge pipe.
As Fig. 4, Fig. 5 and shown in Figure 6, the present invention also provides a kind of batch (-type) chromatography separating method, and it comprises following process:
1) chromatogram systemic circulation separating process: the closed pneumatic valve on closeall chromatographic column and raw material conveying device, eluant, eluent conveying device and the gathering-device connecting line, carry out the circulation of separator internal composition, this process is labeled as the A section;
2) chromatogram partial circulating separating process: open the fast component discharging pneumatic on-off valve that water inlet pneumatic on-off valve that Z1 district chromatographic column is connected with the eluant, eluent conveying device and chromatographic column are connected with the fast component discharge pipe, open the intercolumniation pneumatic on-off valve in Z1 district, Z2 district and Z3 district simultaneously, the fast component of equivalent is discharged in execution when injecting eluant, eluent, this process is labeled as the B section;
3) chromatogram all-in and all-out separating process: carry out simultaneously and utilize eluant, eluent wash-out slow component process and input raw material to discharge equivalent fast component process,
The described eluant, eluent wash-out slow component process of utilizing is to open the slow component discharging pneumatic on-off valve that water inlet pneumatic on-off valve that Z1 district chromatographic column is connected with the eluant, eluent conveying device and chromatographic column are connected with the slow component discharge pipe, carries out the slow component of discharging equivalent when injecting eluant, eluent.This process is labeled as the C section,
It is to open the fast component discharging pneumatic on-off valve that charging pneumatic on-off valve that Z3 district chromatographic column is connected with raw material conveying device and chromatographic column are connected with the fast component discharge pipe that described input raw material is discharged equivalent fast component process, open the intercolumniation pneumatic on-off valve in Z3 district simultaneously, carry out the fast component of when injecting raw material, discharging equivalent.This process is labeled as the D section;
Wherein, before carrying out said process, need the relevant parameter of A, B, C, each section of D is arranged; Described relevant parameter comprises setting flow Qa, Qb, Qc, the Qd of A, B, C, D section, and A, B, C, flow volume Va, the Vb of D section, Vc, Vd.
System of the present invention forms:
A kind of batch (-type) is simulation moving-bed, is made of 4-6 chromatographic column, is that the import and export of each chromatographic column is all installed a pressure sensor PT1, is used for detecting cylinder internal pressure situation of change with the explanation of 6 column systems among Fig. 4; One of variable-frequency circulation dehvery pump is disposed in the outlet of each chromatographic column, is respectively P1, P2, P3, P4, P5, P6; Pump discharge in any one chromatographic column is installed a flowmeter FIC1, in order to control the flow that flows between cylinder, regulate the FIC1 flow by control and the frequency conversion of the chain pump of FIC1, other pumps are as the auxiliary manual adjustments that adopts of the frequency of chain pump, when chain pump is higher than effective range, the illustrative system load is bigger than normal, and the frequency that needs manually to increase other pumps compensates the underpower of this pump, otherwise reduces; Pump discharge in any one chromatographic column is installed a mass flowmenter DIC1, the concentration bands of a spectrum distribution situation in the detection system; The import of each chromatographic column respectively join 2 pneumatic on-off valve KS1 KS2 be used for controlling charging and the water inlet of each cylinder; The outlet of each chromatographic column join 2 pneumatic on-off valve KS4 KS3 be used for controlling slow component and fast component discharging; 1 intercolumniation pneumatic on-off valve of every post intermediate configurations KS5 is used for controlling pipeline between the cylinder; Chromatographic system has the two-way discharging, one group is slow component discharging phase, be provided with a flowmeter FIC4, a control valve FCV4 and a mass flowmenter DIC4 at its discharge pipe, go out the extract flow on flowmeter FIC4 and this pipeline of the chain control of control valve FCV4, mass flowmenter DIC4 detects the discharging dry matter content of slow component; Another group is the fast component discharging, be provided with a flowmeter FIC5, a control valve FCV5 and a mass flowmenter DIC5 at its discharge pipe, discharging flow on flowmeter FIC5 and this pipeline of the chain control of control valve FCV5, mass flowmenter DIC5 detects the discharging dry matter content of fast component; Each cylinder is connected in series by pipe-line system, realizes automatic operating able to programme by the PLC control system.
Water inlet system is the loine pressure PT2 by control valve PCV7 control P7, guarantees the system that enters smoothly of water inlet; Feed system guarantees the system that enters smoothly of charging by the loine pressure PT3 of control PVC8 control P8.
The operating procedure of the method for the invention:
Method of the present invention adopts batch (-type) (multiple step format) method of operation, guarantees that at first pressure P T2, the PT3 of feed system moves under setting pressure, and this is the precondition of system's operation.
Batch (-type) chromatographic isolation technology is divided into 4 sections operations, and namely A, B, C, D are four sections, set 8 operational factors, and Qa, Qb, Qc, Qd represent the setting flow of A, B, C, D section respectively; Va, Vb, Vc, Vd represent the accumulative total volume of every section operation respectively, begin to switch to next step after reaching the accumulative total volume;
As shown in Figure 4, the A section is the closed circuit systemic circulation stage, and external feed and water do not enter system, namely KS1 KS2 be in closed condition, inner separation component is not discharged yet, namely KS4 KS3 all close; 6 circulating pumps of system move simultaneously, the chain frequency adjustment internal system flow by control pump of flowmeter FIC1 and pump is pressed the Qa operation, the change in concentration of DIC1 detection system inside also records concentration curve, when be recycled to the accumulative total volume when reaching Va system switch to the operation of B section.
As shown in Figure 5, the B section is the partial circulating stage, namely only goes out fast component and does not go out slow component, has got rid of the Z4 district.Outside eluting water enters system, and this moment, switch valve KS2 opened, and fast component valve KS3 opens simultaneously, and the fast component of equivalent is exhausted from system; B section circulating pump frequency is manually to set, and frequency output is identical with the A section; B section Z4 does not work, and import and export are closed, i.e. the intercolumniation KS5 valve of the entry and exit of Z4 place post connection cuts out, and other KS5 valve is still opened, and this column outlet circulating pump is stopped; The B section is controlled by 2 operational factors, and one is discharging instantaneous delivery Qb, and one is integrated flow Vb, and discharging flow Qb is by control valve FCV5 control operation; DIC5 detects the dry concentration of discharging, and the bands of a spectrum curve map of record discharging dry; After reaching integrated flow Vb, system switches to next section C, D section.
As shown in Figure 6, the C section is for advancing eluting water wash-out slow component section, this section occurs in the Z1 district, water intaking valve KS2 opens, going out slow component switch valve KS4 opens, the outlet pump operation of Z1 district place post, entering system's eluting water comes out slow component equal-volume wash-out and the discharge system, 2 parameters of C section operation, one is instantaneous delivery Qc, this flow namely is the wash-out water yield that enters system, it also is the discharge rate that the C section goes out slow component, this amount is by FIC4 and the chain control of FCV4, and one is accumulative total volume Vc, switches to the A section of next cylinder after reaching integrated flow.
The D section is discharged the stage for raw material is transfused to system's fast component by equivalent.The D section occurs in the Z3 district, the inlet valve KS1 that enters the Z3 district opens, the switch valve KS3 that goes out the Z3 district opens, the outlet pump operation of Z3 district place post, the KS5 valve between the Z3 district place post is opened, enter system's material liquid with Z3 distinguish from after bodies such as fast component displace system, 2 parameters of D section operation, one is instantaneous delivery Qd, and it is identical with the discharge rate that goes out slow component that this flow is that the D section enters the material quantity of system, and this is measured by FIC5 and the chain control of FCV5; Another parameter is accumulative total volume Vd, namely switches to the A section of next cylinder after the turnover amount reaches integrated flow.
C section and the synchronous operation of D section finish simultaneously, when wherein one section when reaching integrated flow earlier, then need to wait for the operation of the A section that together switches to next cylinder behind another section end of run before repeating.Simulation moving-bed operation is controlled by PLC, regulates control by PID.
System features of the present invention:
A, compare as can be seen with traditional handicraft according to above explanation, new technology A section is to be exclusively used in the stage that circulation separates, this section is that the internal water moving system materials inside by the Z4 district circulates and separates, though the B section has the part input and output material, but still bringing into play the effect that circulation separates, and the B section promotes materials inside by outside fresh water separates, and C, D section feeding and discharging are carried out synchronously, if the flow of turnover is very big, used time ratio is shorter.If system scale is the same like this, compare with traditional handicraft, new technology have centrifugation A B section shared time share in whole separation cycle time portion of increasing charging reduce, be significantly less than the shared time of continuous feed, the new technology separative efficiency improves, good separating effect.
The purposes of eluting water that B, this batch process are intensive.Fresh eluting water is used for wash-out and separates slow component after finishing, and new technology makes fresh unboiled water by focus utilization, has reduced the contaminated chance of water, inner pool good purification; Traditional handicraft is continuously water inlet and wash-out, and fresh water constantly is dispersed in the system in promotion and elution process, and fresh water is few, and contaminated degree is big; When reaching identical clean-up effect, the water loss-rate traditional handicraft that batch (-type) needs reduces greatly.Onesize system, continous way traditional handicraft ton material water consumption is 1.2, the ton material water consumption of batch (-type) separating technology only is 0.8.The eluant, eluent of the present invention and traditional handicraft is utilized situation contrast as shown in Figure 7, and Fig. 7 (a) is utilized the distribution map of situation for the eluant, eluent of traditional handicraft, and Fig. 7 (b) is utilized the distribution map of situation for the eluant, eluent of technology of the present invention.
C, batch (-type) charging have improved the service efficiency of medium.Because the batch (-type) charging is for concentrating feed, raw material only is distributed in the limited scope, the difficult contamination of raw material that is newly entered of the component after the separation, and namely the contaminated degree of resin reduces; Traditional handicraft is for continuing charging, and the raw material that continues to enter constantly is distributed in the system, has taken bigger resin space, easily with separate after the component back-mixing, make the resin space of Z2, Z3 Disengagement zone compressed, separative efficiency descends; Batch process separates same material and can use less separation to be situated between, and the feed distribution situation of the present invention and traditional handicraft contrasts as shown in Figure 8, and Fig. 8 (a) is the feed distribution figure of traditional handicraft, and Fig. 8 (b) is the feed distribution figure of technology of the present invention.
D, batch (-type) separating technology are because interval segmentation is distinct, and same scale can be used short space, and general traditional separating technology adopts the 8-12 post, and batch process adopts the 4-6 post to get final product, and has saved cost of investment greatly.The performance of the present invention and traditional handicraft more as shown in Figure 9, wherein, SMB is the traditional handicraft performance curve, SSMB is processing performance curve of the present invention.
E, because there is the flow that adds up in traditional flow, flow be Q1+Q4 greater than Q3, batch process systemic circulation flow is always Q3, and is less than normal than traditional handicraft, the tangent plane linear velocity of generation is little, cylinder pressure reduction is little, flow is little to system shock in the net system switching process; When the system pressure of general traditional handicraft was 5bar, the system pressure of batch process was that 2.5bar can satisfy with interior, because the flow slight drag is little, the use power of pump is also low.
The present invention has overcome the drawback in traditional continuous analog moving bed piece-rate system, a kind of novel simulation moving-bed new technology of implementation, and convenient, stable, the every index of this technological operation reaches optimization.
Claims (3)
1. batch (-type) chromatographic separation device, comprise separator, raw material conveying device, eluant, eluent conveying device and gathering-device, described raw material conveying device is connected with the input of separator respectively with the eluant, eluent conveying device, the output of described gathering-device and separator is connected, it is characterized in that, described separator comprises some chromatographic columns, the import of described each chromatographic column and outlet all arrange a pressure sensor, each chromatographic column outlet arranges a circulation dehvery pump, one of them exit of described circulation dehvery pump is provided with flowmeter, one of them exit of described circulation dehvery pump is provided with mass flowmenter, and the import department of described each chromatographic column and exit arrange two pneumatic on-off valves respectively; Described raw material conveying device comprises material container and is arranged on control valve and pressure sensor on the feed pipe; Described eluant, eluent conveying device comprises the eluant, eluent container and is arranged on control valve and pressure sensor on the inlet channel; Described gathering-device comprises the two-way discharge pipe, and described each road discharge pipe is respectively arranged with flowmeter, mass flowmenter and control valve.
2. a kind of batch (-type) chromatographic separation device according to claim 1, it is characterized in that, described pneumatic on-off valve comprises charging pneumatic on-off valve, water inlet pneumatic on-off valve, intercolumniation pneumatic on-off valve, slow component discharging pneumatic on-off valve and fast component discharging pneumatic on-off valve, described charging pneumatic on-off valve and water inlet pneumatic on-off valve are arranged on the import department of each chromatographic column, described intercolumniation pneumatic on-off valve is arranged on each chromatographic column connecting pipe, and between chromatographic column import and export pneumatic on-off valve; Described slow component discharging pneumatic on-off valve and fast component discharging pneumatic on-off valve are arranged on the exit of each chromatogram.
3. a kind of batch (-type) chromatographic separation device according to claim 1 is characterized in that, described discharge pipe comprises slow component discharge pipe and fast component discharge pipe.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103071312A (en) * | 2013-02-05 | 2013-05-01 | 山东兆光色谱分离技术有限公司 | Intermittent chromatographic separation device and method |
| CN107158747A (en) * | 2017-05-19 | 2017-09-15 | 南京凯通粮食生化研究设计有限公司 | A kind of decolouring deionization and separating mixture device and operation method |
-
2013
- 2013-02-05 CN CN 201320067446 patent/CN203139686U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103071312A (en) * | 2013-02-05 | 2013-05-01 | 山东兆光色谱分离技术有限公司 | Intermittent chromatographic separation device and method |
| CN107158747A (en) * | 2017-05-19 | 2017-09-15 | 南京凯通粮食生化研究设计有限公司 | A kind of decolouring deionization and separating mixture device and operation method |
| CN107158747B (en) * | 2017-05-19 | 2022-09-16 | 南京凯通粮食生化研究设计有限公司 | Device for decoloring, deionizing and separating mixture and operation method |
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