CN207520646U - Separation system of simulated moving bed chromatography - Google Patents
Separation system of simulated moving bed chromatography Download PDFInfo
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- CN207520646U CN207520646U CN201721298505.6U CN201721298505U CN207520646U CN 207520646 U CN207520646 U CN 207520646U CN 201721298505 U CN201721298505 U CN 201721298505U CN 207520646 U CN207520646 U CN 207520646U
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- pretreatment unit
- chromatographic column
- moving bed
- simulated moving
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Abstract
The utility model belongs to process-scale chromatography purifying plant field, and in particular to a kind of separation system of simulated moving bed chromatography.In the separation system of simulated moving bed chromatography of the utility model, batch can is connect by feed pipe with each pretreatment unit；Eluent tank into eluent pipe with each pretreatment unit by connecting；Pretreatment unit is connect with chromatographic column；Chromatographic column along Flow of Goods and Materials direction next stage and secondary next stage chromatographic column with can mutually connect；Pretreatment unit is obturator, there is processor for ultrasonic wave inside pretreatment unit, and leaving air control valve is arranged at top.The utility model device improves the continuity of production, and simultaneity factor has pretreatment unit, can effectively remove air and impurity in raw material and improve separative efficiency and product purity.
Description
Technical field
The utility model belongs to process-scale chromatography purifying plant field, and in particular to a kind of Simulated Moving Bed Chromatography segregative line
System.
Background technology
Simulated movable bed chromatography device is made of several end to end chromatographic columns into circulation loop, by along mobile phase
Flow direction regularly move import with outlet position come simulate the move counter-current of stationary phase and mobile phase flowing, and then
Realize the separation of different component.Chromatographic technique is combined by the system with simulated moving bed technology, can increase separating capacity, is improved
Product yield.
But there is also some limitations for Simulation moving bed.Firstly, because more root chromatogram columns are connected, each chromatographic column is joined
With wherein, although relatively intermittent improve separative efficiency, in actual production due to being frequently necessary to many chromatographic column strings
Connection, a chromatographic column go wrong, and entire production process can not all carry out.
On the other hand, separation system of simulated moving bed chromatography, often dissolved oxygen or gas, these gases exist for material the inside
Bubble is gathered into system, not only changes running route of the intermediate spaced feed liquid in stationary phase, influences separative efficiency；And
And the oxygen of dissolving can cause stationary phase, such as the oxidation of ion exchange resin, influence stationary phase service life；In addition isolate
Purity is influenced by impurity in raw material.
Invention content
The purpose of the utility model is to overcome the deficiencies in the prior art, provide a kind of Simulated Moving Bed Chromatography segregative line
System.The system changes the pattern of traditional chromatographic column mere in-line, and chromatographic column is connected with next stage and secondary next stage chromatographic column,
Improve production continuity；Pretreatment unit is increased in simultaneity factor, improves separative efficiency and product purity.
In order to achieve the above objectives, the technical solution of the utility model is achieved like this：Simulated Moving Bed Chromatography detaches
System, including batch can, eluent tank, more root chromatogram columns；The system further includes multiple pretreatment units；Batch can by feed pipe with
Each pretreatment unit connection；Eluent tank into eluent pipe with each pretreatment unit by connecting；Pretreatment unit and color
Spectrum column connects one to one；The bottom end of each chromatographic column connects extracting solution collecting pipe, raffinate collecting pipe, first by multiple-way valve
Delivery pipe, the second delivery pipe；Chromatographic column is followed successively by the first chromatographic column by material direction of travel, the second chromatographic column, N chromatographic columns,
N+1 chromatographic columns, N+2 chromatographic columns ...；The outlet of N chromatographic columns is divided into two articles of bypass lines, one article of bypass line and N
+ 1 chromatographic column is connected, and another article of bypass line is connected with N+2 chromatographic columns；N is greater than or equal to 1；Extracting solution collecting pipe connects
Connect extraction flow container；Raffinate collecting pipe connects raffinate flow container；Pretreatment unit is closed cavity, is fixed with inside pretreatment unit
Leaving air control valve is arranged at processor for ultrasonic wave, top.
In addition, double-layer filtering net is arranged at pretreatment unit bottom, which is further improvement of the utility model
Intermediate spaced double-layer filtering net.Convenient for handling impurity in raw material, ensure the purity of product.
Further improvement of the utility model is in addition, for double-layer filtering net, under the mesh size of upper level filter net is more than
The mesh size of layer filter screen.Between impurity is stayed in two layers of filter screen after contaminant filter, it is convenient to clean, while impurity will not
It suspends again.
Further improvement of the utility model is in addition, each pretreatment unit upper end is respectively arranged with inlet valve, into elution
Agent valve.Since the position that system regularly moves import and outlet is flowed to simulate the move counter-current of stationary phase and mobile phase,
Setting control valve can be well matched with entrance location replacement.
Further improvement of the utility model in addition, inlet valve, into eluent valve, multiple-way valve, leaving air control valve with from
Autocontrol system connects, and realizes production automation, easy to operation.
The beneficial effects of the utility model：(1) system changes the pattern of traditional chromatographic column mere in-line, by chromatographic column
It mutually can connect with next stage and secondary next stage chromatographic column, when level-one chromatographic column goes wrong, overhaul simultaneously, it may be connected to next
Grade chromatographic column works on, and ensure that production continuity；(2) pretreatment unit is increased in system, is had in pretreatment unit super
Acoustic processor can effectively remove the gas in mobile phase；(3) there is double medium filtration in increased pretreatment unit in system
Net effectively removes the impurity of raw material, ensures product purity.
Description of the drawings
Fig. 1 is the utility model separation system of simulated moving bed chromatography structure diagram.
Fig. 2 is the utility model pretreatment unit structure diagram.
In figure：1st, batch can, 2, eluent tank, 3, feed pipe, 4, into eluent pipe, 5, pretreatment unit, 6, chromatographic column, 7,
Raffinate flow container, 8, filter screen, 9, extraction flow container, 10, raffinate collecting pipe, 11, extracting solution collecting pipe, 12, leaving air control valve,
13rd, processor for ultrasonic wave, 14, multiple-way valve, the 15, first delivery pipe, the 16, second delivery pipe.
Specific embodiment
The utility model is further described with reference to the accompanying drawings and detailed description.
Embodiment 1：Separation system of simulated moving bed chromatography, including batch can 1, eluent tank 2,4 root chromatogram columns 6, pretreatment
Device 5；Batch can 1 is connect by feed pipe 3 with each pretreatment unit 5；Eluent tank 2 by into eluent pipe 4 with it is each pre-
Processing unit 5 connects；Pretreatment unit 5 connects one to one with chromatographic column 6；The bottom end of each chromatographic column 6 passes through multiple-way valve 14
Connect extracting solution collecting pipe 11, raffinate collecting pipe 10, the first delivery pipe 15, the second delivery pipe 16；Chromatographic column 6 with along material
The next stage of flow direction and secondary next stage chromatographic column feed inlet can mutually connect；The first delivery pipe 15 such as the first root chromatogram column connects
Second root chromatogram column feed inlet, the second delivery pipe 16 connection third root chromatogram column feed inlet of the first root chromatogram column；Along material
The first delivery pipe 15 and the second delivery pipe 16 of 4th root chromatogram column of flow direction connect the first root chromatogram column and second respectively
Chromatographic column；The connection extraction flow container 9 of extracting solution collecting pipe 11；Raffinate collecting pipe 10 connects raffinate flow container 7；Pretreatment unit 5 is
Closed cavity has processor for ultrasonic wave 13 inside pretreatment unit 5, and leaving air control valve 12 is arranged at top；5 bottom of pretreatment unit has
Double-layer filtering net 8, the double-layer filtering net 8 are intermediate spaced double-layer filtering net 8.For double-layer filtering net 8, upper level filter net
Mesh size be more than lower floor's filter screen mesh size；Each 5 upper end of pretreatment unit is respectively arranged with inlet valve, into elution
Agent valve；Inlet valve is connect into eluent valve, multiple-way valve 14, leaving air control valve 12 with automatic control system.
In actual motion, when level-one chromatographic column goes wrong, it may be connected to which next stage chromatographic column works on, and ensures
Production continuity.It is such as fed in production in the first root chromatogram column, when the second root chromatogram column appearance event along logistics direction
Barrier can turn off the first delivery pipe 15, open the second delivery pipe 16, and feed liquid flows into third root chromatogram column and works on.Pretreatment
There is ultrasonic processor 13 in device 5, in ultrasonic procedure, can effectively remove the gas in mobile phase, gas passes through outlet
Control valve 12 is discharged.There is double-layer filtering net 8 in pretreatment unit 5, effectively remove the impurity of raw material, ensure product purity.
Claims (5)
1. separation system of simulated moving bed chromatography, including batch can (1), eluent tank (2), more root chromatogram columns (6), feature exists
In：The system further includes multiple pretreatment units (5)；The batch can (1) passes through feed pipe (3) and each pretreatment unit (5)
Connection；The eluent tank (2) into eluent pipe (4) with each pretreatment unit (5) by connecting；The pretreatment unit
(5) it connects one to one with chromatographic column (6)；The bottom end of each chromatographic column (6) connects extracting solution collecting pipe by multiple-way valve (14)
(11), raffinate collecting pipe (10), the first delivery pipe (15), the second delivery pipe (16)；The chromatographic column (6) is by material traveling side
To being followed successively by the first chromatographic column, the second chromatographic column, N chromatographic columns, N+1 chromatographic columns, N+2 chromatographic columns ...；The N colors
The outlet of spectrum column is divided into two bypass lines, and one article of bypass line is connected with N+1 chromatographic columns, another article of bypass line and the
N+2 chromatographic columns are connected；The N is greater than or equal to 1；Extracting solution collecting pipe (11) the connection extraction flow container (9)；The raffinate
Liquid collecting pipe (10) connection raffinate flow container (7)；The pretreatment unit (5) is closed cavity；It is fixed inside pretreatment unit (5)
There is processor for ultrasonic wave (13), have leaving air control valve (12) at the top of pretreatment unit (5).
2. separation system of simulated moving bed chromatography according to claim 1, it is characterised in that：The pretreatment unit (5)
Double-layer filtering net (8) is arranged at bottom, which is intermediate spaced double-layer filtering net (8).
3. separation system of simulated moving bed chromatography according to claim 2, it is characterised in that：The double-layer filtering net (8)
In, the mesh size of upper level filter net is more than the mesh size of lower floor's filter screen.
4. separation system of simulated moving bed chromatography according to claim 1, it is characterised in that：Each pretreatment unit (5)
Upper end is respectively arranged with inlet valve, into eluent valve.
5. separation system of simulated moving bed chromatography according to claim 4, it is characterised in that：The inlet valve, into elution
Agent valve, multiple-way valve (14), leaving air control valve (12) are connect with automatic control system.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721298505.6U CN207520646U (en) | 2017-10-10 | 2017-10-10 | Separation system of simulated moving bed chromatography |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721298505.6U CN207520646U (en) | 2017-10-10 | 2017-10-10 | Separation system of simulated moving bed chromatography |
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| Publication Number | Publication Date |
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| CN207520646U true CN207520646U (en) | 2018-06-22 |
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| CN201721298505.6U Active CN207520646U (en) | 2017-10-10 | 2017-10-10 | Separation system of simulated moving bed chromatography |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116162796A (en) * | 2021-11-24 | 2023-05-26 | 中国科学院青岛生物能源与过程研究所 | Magnesium-lithium separation device applied to brine lithium extraction process |
-
2017
- 2017-10-10 CN CN201721298505.6U patent/CN207520646U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116162796A (en) * | 2021-11-24 | 2023-05-26 | 中国科学院青岛生物能源与过程研究所 | Magnesium-lithium separation device applied to brine lithium extraction process |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20191120 Address after: 256200, No. two, No. 558, Zouping economic and Technological Development Zone, Binzhou, Shandong Patentee after: Shandong Trillion Chromatography Separation Technology Co., Ltd. Address before: 200120 616, room 2, Hai Tai Lou, 351 Guo Shou Jing Road, Shanghai free trade zone. Patentee before: Shanghai Zhao Guang Biological Engineering Design Research Institute Co Ltd |