CN2832294Y - Automatic flow path separating device - Google Patents
Automatic flow path separating device Download PDFInfo
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- CN2832294Y CN2832294Y CN 200520129574 CN200520129574U CN2832294Y CN 2832294 Y CN2832294 Y CN 2832294Y CN 200520129574 CN200520129574 CN 200520129574 CN 200520129574 U CN200520129574 U CN 200520129574U CN 2832294 Y CN2832294 Y CN 2832294Y
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Abstract
The utility model relates to an automatic flow path separating device which comprises a solvent bottle, a liquid transfer pump, a six-way valve, a separating element, and a sample bottle and a collecting bottle, wherein the solvent bottle is connected with the liquid transfer pump by a pipeline, the six-way valve is connected with the separating element by a pipeline, and the separating element is connected with the collecting device by a pipeline. The utility model is characterized in that the automatic flow path separating device also comprises three three-way valves, a plunger pump and a sampling /collecting device, wherein the three three-way valves are respectively connected with the six-way valve by pipelines. One outlet of the first of the three-way valves is connected with a waste liquid pipe, and another outlet is connected with the liquid transfer pump via a pipeline. Another inlet and another outlet of the second of the three-way valves are respectively connected with the plunger pump and the solvent bottle via pipelines. Another inlet and another outlet of the third of the three-way valves are respectively connected with the separating element and the sampling / collecting device via pipelines. The utility model not only overcomes the fussy manual operation existing in the prior art but also can improve the repetition accuracy of the analysis efficiency and the analysis result. At the same time, the flow path is simple and the production cost and the routine maintenance cost of an apparatus are reduced.
Description
Technical field
The utility model relates to the separation flow circuit device that uses in the processes such as a kind of biological or chemical sample separation, preparation, particularly about a kind of automatic flow-path separation device.
Background technology
(with the chromatograph is example to existing common separation flow circuit device, as shown in Figure 1) mainly comprise solvent bottle 1, woven hose 2, infusion pump 4, woven hose 5, six-way valve 8, woven hose 13, resolution element 14 (chromatographic column), woven hose 15, detector 16, woven hose 19, the gatherer 20 that connects successively, and sample bottle 23 etc.In the analytic process, sample introduction, collection generally are to carry out loaded down with trivial details operation by craft, and analysis efficiency is low, repeatable accuracy is poor.And existing automatic flow-path separation device complex structure, the instrument manufacturing cost is very high and difficult in maintenance.
Summary of the invention
At the problems referred to above, the purpose of this utility model is that the stream to above-mentioned separation flow circuit device improves, and makes its switching by various valves, can realize the separation flow circuit device of control automatically.
For achieving the above object, the utility model is taked following technical scheme: a kind of automatic flow-path separation device, and it comprises solvent bottle, infusion pump, six-way valve, resolution element, reaches sample bottle and receiving flask; Described solvent bottle connects described infusion pump by pipeline, described six-way valve connects described resolution element by pipeline, described resolution element connects described gatherer by pipeline, it is characterized in that: it also comprises three triple valves that connect described six-way valve respectively by pipeline, a plunger displacement pump and a sampling/gatherer; An outlet of first described triple valve connects a sewer pipe, and another outlet connects described infusion pump by pipeline; Two import and export in addition of second described triple valve connect described plunger displacement pump and solvent bottle by pipeline respectively; Two import and export in addition of the 3rd described triple valve connect described resolution element and sampling/gatherer by pipeline respectively.
On the pipeline between described resolution element and the 3rd triple valve, be connected a detector.
Described resolution element comprises and can or dissolve in the chromatographic column that the biased sample of solvent separates with the liquid biased sample, gel column, ion exchange column, the column jecket that the counter-current separation method is used, the distributing trough that the centrifugal partition chromatograph method is used, the capillary that the capillary electrophoresis separation sample is used, a kind of in the solvent distillation post.
Therefore the utility model can pass through the switching of control triple valve, six-way valve owing in existing separation flow circuit device, increased by three triple valves, plunger displacement pump and sampling/gatherers, and increased electric controller; To the control of plunger displacement pump and sampling/gatherer, make the utility model finish the quantitative sampling of sample, cleaning, sample separation automatically, collect, abandon five processes.So not only overcome fussy hand operation in the prior art, and can improve analysis efficiency and analysis result repeatable accuracy, and lowering apparatus production cost and regular maintenance expense.
Description of drawings
Fig. 1 is that separation flow circuit device of the prior art constitutes schematic diagram
Fig. 2 is a formation schematic diagram of the present utility model
Fig. 3 is another embodiment of the present utility model
Fig. 4 is a control circuit block diagram of the present utility model.
The specific embodiment
As shown in Figure 1 and Figure 2, flow path system of the present utility model removes solvent bottle 1, pipeline 2, infusion pump 4, pipeline 5, six-way valve 8, pipeline 13, resolution element 14, pipeline 15, detector 16, pipeline 19, the gatherer 20 that connects successively that comprise same as the prior art, and beyond the sample bottle 23, principal character is to have increased by 6,10,18 and plunger displacement pumps 12 of three triple valves, and gatherer 20 is to have sampling concurrently and be collected in sampling/gatherer 24 all over the body simultaneously.Wherein, first triple valve 6 connects infusion pump 4, connects a six-way valve 8 and a sewer pipe 21 by pipeline 7 by pipeline 5 respectively; Second triple valve 10 connects solvent bottle 1, connects six-way valve 8 and be connected plunger displacement pump 12 by pipeline 11 by pipeline 9 by pipeline 3 respectively; The 3rd triple valve 18 passes through pipeline 17 connection detectors 16 respectively and is connected sampling/gatherer 24 by pipeline 19.
As shown in Figure 3, in the foregoing description,, can not use detector 16, just resolution element 14 directly connects triple valve 18 by pipeline 15 if determined under the condition of disengaging time.
As Fig. 2, shown in Figure 4, in the foregoing description, each triple valve 6,10,18, six-way valve 8, plunger displacement pump 12 all can be controlled each motor-driven by drive circuit, and such as being driven triple valve 6 by motor M 1 to connect six-way valve 8, the solvent of control whole instrument is supplied with or discharged; Motor M 2 drives triple valves 10 and links to each other with solvent bottle 1, plunger displacement pump 12 and six-way valve 8, finish at sample introduction with when cleaning sample introduction needle to sample quantitatively extraction and solvent streams to control; Solvent when motor M 3 drives triple valves 18 control sample introductions and separated and collected and sample flow to.Motor M 4 drives six-way valve 8 controls and external sample is transferred to the assembly of analyzing stream; Motor M 5 drives the cooperation of plunger displacement pump 12 and triple valve 10, finishes the function of quantitative extraction solvent and sample.Solvent bottle 1 is stored and is provided solvent as the system flow phase, and infusion pump 4 inlets are connected with solvent bottle 1 by pipeline 2, and infusion pump 4 can be opened all the time, extracts solvent and supplies with the constant mobile solvent of whole piping flow; Resolution element 14 is assemblies of sample separation: detector 16 is assemblies of test sample.Sampling/gatherer 24 that the utility model adopts is prior art parts, and it both can form sampling components with sample bottle 23, can form collection assembly with the receiving flask (not shown) again, and receiving flask is collected is sample component after separating.
In the foregoing description, sample introduction, elution analysis and the requirement that needs test sample to collect per sample can start different motor realizations by general logic control and drive circuit according to the order of stream operation, be not characteristics of the present utility model, do not repeat them here.
The dynamic process that need finish with regard to the utility model describes below, and the utility model comprises: system's cleaning, draw samples, sample separation, collect and abandon five dynamic processes (as shown in Figure 2):
When 1, automatic flow-path separation device is in original state, the solvent path direction is: solvent bottle 1-pipeline 2-infusion pump 4-pipeline 5-triple valve 6-pipeline 7-six-way valve 8-pipeline 13-resolution element 14-pipeline 15-detector 16-pipeline 17-triple valve 18-pipeline 19-sampling/gatherer 24, this cleans state for the sample analysis pipeline.
2, when automatic flow-path separation device is in the draw samples state, sampling/gatherer 24 inserts sample bottle 23, motor M 3 drives triple valve 18 and makes pipeline 19,22 are communicated with, the reversing bar connecting pipeline 22 that motor M 4 drives in the six-way valve 8,9, motor M 2 drives triple valve 10 and makes pipeline 9,11 are communicated with, motor M 5 drives plunger displacement pump 12 and does the pull action, the solvent path direction is: sample bottle 23-sampling/gatherer 24-pipeline 19-triple valve 18-pipeline 22-six-way valve 8-pipeline 9-triple valve 10-pipeline 11-plunger displacement pump 12, through a pull of plunger displacement pump 12, just can reach the purpose of automatic ration sampling by the switching of reversing bar in the six-way valve 8.
3, automatic flow-path separation device is in when washing the sample lines state, sampling/gatherer 24 shifts out sample bottle 23, triple valve 18 is motionless, motor M 4 drives six-way valve 8 commutations and makes its interior reversing bar connecting pipeline 7,13, sample separation is carried out in preparation, motor M 2 drives triple valve 10 switchings and makes pipeline 3,9,11 all are communicated with, motor M 5 drives plunger displacement pump 12 and does the pull action, the solvent path direction is: solvent bottle 1-pipeline 3-triple valve 10-pipeline 9-six-way valve 8-pipeline 22-triple valve 18-pipeline 19-sampling/gatherer 24, the waste liquid of washing sample lines is entered waste liquid pool, plunger displacement pump 12 repeatedly pull several times so that sample lines cleans up.
When carrying out sample drawing and washing sample lines, the state of triple valve 6 is in pipeline 7 closing state all the time, and the solution path direction is: solution bottle 1-pipeline 2-infusion pump 4-pipeline 5-triple valve 6-sewer pipe 21, waste liquid is introduced waste liquid pool.
When 4, automatic flow-path separation device is in the sample separation state, the pipeline 3,9 of triple valve 10 is closed, the pipeline 21 that motor M 1 drives triple valve 6 is closed, pipeline 7 is opened, and the solvent path direction is: solution bottle 1-pipeline 2-infusion pump 4-pipeline 5-triple valve 6-pipeline 7-six-way valve 8-pipeline 13-resolution element 14-pipeline 15-detector 16-pipeline 17-triple valve 18-pipeline 19-sampling/gatherer 24.Observe detector 16 in elution process, unwanted component is introduced waste liquid pool, this is for abandoning; Peak value occurs in case find the component that needs, just begin to collect the sample component that is detected with receiving flask.
5, after first sample separation is collected and finished, get back to original state again, carry out the sample analysis pipeline and clean.Sample to remainder repeats aforementioned separation process one by one then, till whole sample separation finish.
Under situation, can remove detector in above-mentioned each stream without detector.
Claims (4)
1, a kind of automatic flow-path separation device, it comprises solvent bottle, infusion pump, six-way valve, resolution element, reaches sample bottle and receiving flask; Described solvent bottle connects described infusion pump by pipeline, described six-way valve connects described resolution element by pipeline, described resolution element connects described gatherer by pipeline, it is characterized in that: it also comprises three triple valves that connect described six-way valve respectively by pipeline, a plunger displacement pump and a sampling/gatherer; An outlet of first described triple valve connects a sewer pipe, and another outlet connects described infusion pump by pipeline; Two import and export in addition of second described triple valve connect described plunger displacement pump and solvent bottle by pipeline respectively; Two import and export in addition of the 3rd described triple valve connect described resolution element and sampling/gatherer by pipeline respectively.
2, a kind of automatic flow-path separation device as claimed in claim 1 is characterized in that: be connected a detector on the pipeline between described resolution element and the 3rd triple valve.
3, a kind of automatic flow-path separation device as claimed in claim 1 or 2, it is characterized in that: described resolution element comprises the chromatographic column that the liquid biased sample can be separated, gel column, ion exchange column, the column jecket that the counter-current separation method is used, the distributing trough that the centrifugal partition chromatograph method is used, the capillary that the capillary electrophoresis separation sample is used, a kind of in the solvent distillation post.
4, a kind of automatic flow-path separation device as claimed in claim 1 or 2, it is characterized in that: described resolution element comprises the chromatographic column of the biased sample separation that dissolves in solvent, gel column, ion exchange column, the column jecket that the counter-current separation method is used, the distributing trough that the centrifugal partition chromatograph method is used, the capillary that the capillary electrophoresis separation sample is used, a kind of in the solvent distillation post.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200520129574 CN2832294Y (en) | 2005-10-25 | 2005-10-25 | Automatic flow path separating device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200520129574 CN2832294Y (en) | 2005-10-25 | 2005-10-25 | Automatic flow path separating device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN2832294Y true CN2832294Y (en) | 2006-11-01 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200520129574 Expired - Fee Related CN2832294Y (en) | 2005-10-25 | 2005-10-25 | Automatic flow path separating device |
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| CN (1) | CN2832294Y (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101601967B (en) * | 2009-07-20 | 2011-06-22 | 中国检验检疫科学研究院 | Four-channel full automatic gel permeation purification system for macromolecule |
| CN101602022B (en) * | 2009-07-20 | 2011-08-17 | 中国检验检疫科学研究院 | Automatic rotating liquid adding and extracting volume fixing device |
| CN107179359A (en) * | 2017-05-02 | 2017-09-19 | 维科托（北京）科技有限公司 | Flow path system for liquid chromatogram atomic fluorescence combined instrument |
| CN114923993A (en) * | 2022-04-15 | 2022-08-19 | 华南理工大学 | Liquid chromatography system based on pre-column online derivation method and use method |
-
2005
- 2005-10-25 CN CN 200520129574 patent/CN2832294Y/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101601967B (en) * | 2009-07-20 | 2011-06-22 | 中国检验检疫科学研究院 | Four-channel full automatic gel permeation purification system for macromolecule |
| CN101602022B (en) * | 2009-07-20 | 2011-08-17 | 中国检验检疫科学研究院 | Automatic rotating liquid adding and extracting volume fixing device |
| CN107179359A (en) * | 2017-05-02 | 2017-09-19 | 维科托（北京）科技有限公司 | Flow path system for liquid chromatogram atomic fluorescence combined instrument |
| CN114923993A (en) * | 2022-04-15 | 2022-08-19 | 华南理工大学 | Liquid chromatography system based on pre-column online derivation method and use method |
| CN114923993B (en) * | 2022-04-15 | 2023-06-20 | 华南理工大学 | Liquid chromatography system based on pre-column online derivatization method and application method |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20061101 Termination date: 20091025 |