CN203954732U - A kind of Multi-channel solid phase extraction device - Google Patents
A kind of Multi-channel solid phase extraction device Download PDFInfo
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- CN203954732U CN203954732U CN201420122623.1U CN201420122623U CN203954732U CN 203954732 U CN203954732 U CN 203954732U CN 201420122623 U CN201420122623 U CN 201420122623U CN 203954732 U CN203954732 U CN 203954732U
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Abstract
The utility model belongs to Sample Pretreatment Technique Used field, relates to a kind of Multi-channel solid phase extraction device.This device comprises solid-phase extraction column, wash-out frame, multichannel push-and-pull syringe pump, syringe, waste liquid bottle, receiving flask and flexible pipe.The difference of flow velocity between post and post when this device not only can be eliminated operation repetitive, and can guarantee that between different operating batch, liquid can pass through solid-phase extraction column with the speed of presetting.
Description
Technical field
The utility model belongs to Sample Pretreatment Technique Used field, particularly relates to a kind of Multi-channel solid phase extraction device.
Background technology
SPE (Solid-Phase Extraction, be called for short SPE) be a kind of Sample Pretreatment Technique Used from last century, the eighties grew up mid-term, be mainly used in separation, the purifying and concentrated of sample, compare with traditional liquid-liquid extraction method, SPE can improve the rate of recovery of analyte, more effective that analyte is separated with interfering component, reduce sample substrate and disturb, improve detection sensitivity.Solid phase extraction techniques, since coming out, has played a part more and more important in fields such as food analysis, environment, pharmacy, biomedicines.The factor that affects SPE effect mainly contains selection, retention volume and the flow velocity of the selection of adsorbent, eluting solvent.Wherein the control of flow velocity is most important to SPE process, the excessive leakage that easily causes solid-phase extraction column of flow velocity, and sample to be analyzed can not fully act on adsorbent, reduces sample recovery rate and clean-up effect, and the too small processing speed of flow velocity is too slow.Flow velocity is on the one hand relevant with sample viscosity to be analyzed with the filling situation of solid-phase extraction column, relevant with practical operation and solid-phase extraction device used on the other hand.
Conventionally solid-phase extraction device adds fluid sample in use from solid-phase extraction column upper end, and sample liquid is at gravity or apply under External Force Acting and flow out by solid-phase extraction column lower end.The mode that solid-phase extraction device of the prior art applies external force mainly contains negative pressure mode and malleation mode: negative pressure mode is controlled sample liquid and flow through SPE pillar and realize extraction process by vacuumizing, the feature of negative-pressure type solid-phase extraction device is simple in structure, and the square cylinder formula solid-phase extraction device of laboratory extensive use at present adopts negative pressure mode exactly.And malleation mode maintains continuous malleation by apply the uniform air of air-flow or nitrogen above solid phase extraction column, to each column jecket, provide identical pressure.Malleation mode to a certain degree overcome that common in the market negative pressure of vacuum solid-phase extraction device often occurs because of problem that between distance different posts that produce between pillar leakage fluid dram position and vacuum port and post, flow velocity differs greatly.But in actual applications; the sample fluid viscosity that SPE process relates to often has bigger difference; each solid-phase extraction column is applied to same pressure can cause the speed of different solid-phase extraction columns lower end efflux different; in addition; between the solid-phase extraction column of same packing, because adsorbent filling tightness degree difference causes internal pressure difference, be also ubiquitous; even if therefore handled sample fluid viscosity is identical, be also difficult to guarantee that liquid flows out with identical speed, thereby affect the rate of recovery and the reappearance of sample.Although a lot of solid-phase extraction devices are all furnished with flow rate regulating valve, this control valve can only be regulated respectively by the eye estimate rate of outflow, the flow velocity difference while being difficult to avoid operation repetitive between post and post.
Utility model content
The deficiency existing for prior art, the utility model proposes a kind of accurately coutroi velocity, avoids the Multi-channel solid phase extraction device of cross pollution.
This device comprises solid-phase extraction column, wash-out frame, multichannel push-and-pull syringe pump, syringe, waste liquid bottle, receiving flask and flexible pipe;
Wherein
Described solid-phase extraction column is used for holding solution, and it comprises an outlet;
Described wash-out sets up and is equipped with a joint;
The outlet of described solid-phase extraction column is connected with the upper end of described joint;
Described syringe comprises the first outlet, the second outlet and the 3rd outlet, and described the first outlet is vertically outlet, and described the second outlet and the 3rd outlet are Horizontal Exit;
Described syringe is installed on described multichannel push-and-pull syringe pump, and described the first outlet is connected with the lower end of described joint;
Described the second outlet is connected to described waste liquid bottle by described flexible pipe;
Described the 3rd outlet is connected to described receiving flask by described flexible pipe.
Further,
Described joint is provided with valve, and described upper valve is controlled the outflow of solution in described solid-phase extraction column;
Described the second outlet and the 3rd outlet are respectively arranged with valve;
Described waste liquid bottle and receiving flask are external.
Preferably,
Described wash-out frame and syringe can be selected polytetrafluoroethylene (PTFE) material, and described flexible pipe can be selected polyether-ether-ketone flexible pipe.
The utility model Multi-channel solid phase extraction device has following technique effect:
Liquid in solid-phase extraction column steadily passes through solid-phase extraction column with predefined speed under the effect of multichannel push-and-pull syringe pump, the difference of flow velocity between post and post while not only having eliminated operation repetitive, and can guarantee that liquid between different operating batch can be with the speed preset by solid-phase extraction column, accurately, flow control has guaranteed higher sample recovery rate and precision stably; By waist valve and eluent on the effect cooperation syringe of multichannel push-and-pull syringe pump, collect the switch of valve and realize easily the discharge of waste liquid and the collection of eluent.
Its advantage with respect to prior art is:
First, waste liquid bottle and receiving flask are all external, have overcome traditional solid-phase extraction device because inner space restriction must be shifted waste liquid and defect that cannot disposable collecting large volume eluent in time.
In addition, by multichannel push-and-pull syringe pump, for SPE process provides power, overcome traditional solid-phase extraction device owing to using the larger defect of vavuum pump noise.
In addition, waste liquid directly enters waste liquid bottle through polyether-ether-ketone (PEEK) flexible pipe, has reduced the chance of the direct organic solvent exposure of experimenter, is conducive to safeguard work personnel's health.
In general, of the present utility model simple in structure, assembling is compact, easy to use, and flexible operation is safe and reliable, applied widely, and lower being easy to of cost promoted.
Accompanying drawing explanation
Fig. 1 is the schematic diagram of the parts solid-phase extraction column of the utility model Multi-channel solid phase extraction device;
Wherein, 1 is solid-phase extraction column
Fig. 2 is the schematic diagram of the parts wash-out frame of the utility model Multi-channel solid phase extraction device;
Wherein, 2 is wash-out frame
Fig. 3 is the schematic diagram of the parts multichannel push-and-pull syringe pump of the utility model Multi-channel solid phase extraction device;
Wherein, 3 is multichannel push-and-pull syringe pump
Fig. 4 is the schematic diagram of the parts syringe of the utility model Multi-channel solid phase extraction device;
Wherein, 4 is syringe
Fig. 5 is the schematic diagram of the parts flexible pipe of the utility model Multi-channel solid phase extraction device;
Wherein, 5 is flexible pipe
Fig. 6 is the schematic diagram of the parts waste liquid bottle of the utility model Multi-channel solid phase extraction device;
Wherein, 6 is waste liquid bottle
Fig. 7 is the schematic diagram of the parts receiving flask of the utility model Multi-channel solid phase extraction device;
Wherein, 7 is receiving flask
Fig. 8 is the schematic diagram of each building block assembling mode of Multi-channel solid phase extraction device.
The specific embodiment
For making those skilled in the art further understand the technical solution of the utility model, the concrete structure of Multi-channel solid phase extraction device the utility model being proposed below in conjunction with accompanying drawing is elaborated.
Fig. 1～7 show each building block of the utility model device, and wherein, 1 is solid-phase extraction column (a plurality of), and 2 is wash-out frame, and 3 is multichannel push-and-pull syringe pump, and 4 is syringe, and 5 is flexible pipe, and 6 is waste liquid bottle, and 7 is receiving flask (a plurality of).For above-mentioned building block, solid-phase extraction column 1, for holding sample or determinand solution, can be selected different specifications according to analytic sample character and determinand character, such as the standard solid-phase extraction column that can select the plurality of specifications such as 1mL, 3mL, 6mL, 12mL; Wash-out frame 2 adopts polytetrafluoroethylmaterial material to make, this material is that common plastic material is in having erosion-resisting characteristic durable in use, polytetrafluoroethylene (PTFE) joint is housed on wash-out frame 2, be used for connecting solid-phase extraction column 1 and syringe 4, this joint is provided with valve, can control the outflow of liquid in solid-phase extraction column 1 by valve switch; Multichannel push-and-pull syringe pump 3 is existing product, available on market, for SPE process provides power, can control push pull maneuver and flow rate of liquid by operation interface; Syringe 4 is made by polytetrafluoroethylmaterial material, volume 10mL, the exit of syringe 4 is threeway pattern, be that syringe 4 comprises three outlets, wherein two Horizontal Exits in left and right are equipped with valve, are respectively waist valve and eluent and collect valve, two of left and right Horizontal Exit connecting hose 5, receive respectively waste liquid bottle 6 and receiving flask 7, by valve switch, control the discharge of waste liquid and the collection of eluent; Another one vertically outlet is connected with wash-out frame 2 joint lower ends; Waste liquid bottle 6 can be the conventional container of collecting waste liquid in laboratory; Receiving flask 7 can be selected as required, and as the concentrated bottle of the concentrated test tube of the sample bottle of chromatograph automatic sampler, Nitrogen evaporator or Rotary Evaporators etc., waste liquid bottle 6 and receiving flask 7 are all external.Flexible pipe 5 can be selected polyether-ether-ketone (PEEK) flexible pipe.
Fig. 8 shows the assembling mode of each building block of the utility model device.Wherein, the upper end of 2 one joints of the outlet of a solid-phase extraction column 1 and wash-out frame is connected; A syringe 4 is installed in multichannel push-and-pull syringe pump 3, and it vertically exports and be connected with the lower end of wash-out frame 2 above-mentioned joints, and two of the left and right Horizontal Exit of this syringe 4 connects respectively PEEK flexible pipe 5, then is connected respectively to waste liquid bottle 6 and receiving flask 7.
The specific operation process of the utility model device is as follows:
All solid-phase extraction columns 1 and syringe 4 are installed, and the Horizontal Exit of each syringe 4 is connected with receiving flask 7 with waste liquid bottle 6 by PEEK flexible pipe.Solution is added in solid-phase extraction column 1, open the upper valve of wash-out frame 2, close waist valve and the eluent of syringe 4 simultaneously and collect valve, opening multichannel push-and-pull syringe pump 3 sets extraction speed and extracts liquid measure, bring into operation, the solution-stabilized pillar that passes through in each solid-phase extraction column 1, completes the upper valve of closing wash-out frame 2 afterwards.As need, collect by the solution of solid-phase extraction column 1, open the eluent of syringe 4 and collect valve, if do not needed, do not collect, open waist valve, then injection speed and the injection liquid measure of setting multichannel push-and-pull syringe pump 4, bring into operation, and solution is collected or is discharged in waste liquid bottle 6 by receiving flask 7.To activate solvent, sample solution to be clean, leacheate and eluent and according to said process, pass through successively solid-phase extraction column 1 respectively, realize the purification of sample.
Claims (6)
1. a Multi-channel solid phase extraction device, is characterized in that:
Comprise solid-phase extraction column, wash-out frame, multichannel push-and-pull syringe pump, syringe, waste liquid bottle, receiving flask and flexible pipe;
Wherein
Described solid-phase extraction column is used for holding solution, and it comprises an outlet;
Described wash-out sets up and is equipped with a joint;
The outlet of described solid-phase extraction column is connected with the upper end of described joint;
Described syringe comprises the first outlet, the second outlet and the 3rd outlet, and described the first outlet is vertically outlet, and described the second outlet and the 3rd outlet are Horizontal Exit;
Described syringe is installed on described multichannel push-and-pull syringe pump, and described the first outlet is connected with the lower end of described joint;
Described the second outlet is connected to described waste liquid bottle by described flexible pipe;
Described the 3rd outlet is connected to described receiving flask by described flexible pipe.
2. Multi-channel solid phase extraction device according to claim 1, is characterized in that:
Described joint is provided with valve, and described upper valve is controlled the outflow of solution in described solid-phase extraction column.
3. Multi-channel solid phase extraction device according to claim 1, is characterized in that:
Described the second outlet and the 3rd outlet are respectively arranged with valve.
4. Multi-channel solid phase extraction device according to claim 1, is characterized in that:
Described wash-out frame and syringe can be selected polytetrafluoroethylene (PTFE) material.
5. Multi-channel solid phase extraction device according to claim 1, is characterized in that:
Described flexible pipe can be selected polyether-ether-ketone flexible pipe.
6. Multi-channel solid phase extraction device according to claim 1, is characterized in that:
Described waste liquid bottle and receiving flask are external.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420122623.1U CN203954732U (en) | 2014-03-13 | 2014-03-13 | A kind of Multi-channel solid phase extraction device |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201420122623.1U CN203954732U (en) | 2014-03-13 | 2014-03-13 | A kind of Multi-channel solid phase extraction device |
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| CN203954732U true CN203954732U (en) | 2014-11-26 |
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| CN201420122623.1U Expired - Fee Related CN203954732U (en) | 2014-03-13 | 2014-03-13 | A kind of Multi-channel solid phase extraction device |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106018613A (en) * | 2016-06-23 | 2016-10-12 | 西安交通大学 | Solid-phase extraction device capable of realizing multi-column series connection through online switching and extraction method of solid-phase extraction device |
| CN106345142A (en) * | 2015-07-13 | 2017-01-25 | 中国石油化工股份有限公司 | Solid phase extracting device |
| CN106908513A (en) * | 2017-03-09 | 2017-06-30 | 浙江大学 | It is a kind of for 96 hole high flux solid-phase extraction devices of mass spectral analysis and its application |
| CN108226357A (en) * | 2018-02-01 | 2018-06-29 | 南京信息工程大学 | A kind of device for eluting DNPH sampling columns |
| CN109646997A (en) * | 2019-01-08 | 2019-04-19 | 成都理工大学 | A kind of parallel automatic solid-phase extractor of corrosion-resistant multi-channel |
| CN110927298A (en) * | 2019-11-20 | 2020-03-27 | 西安交通大学医学院第二附属医院 | Device capable of processing multiple samples at one time |
| CN111643928A (en) * | 2020-06-12 | 2020-09-11 | 中国地质大学（武汉） | Automatic solid phase extraction device |
-
2014
- 2014-03-13 CN CN201420122623.1U patent/CN203954732U/en not_active Expired - Fee Related
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106345142A (en) * | 2015-07-13 | 2017-01-25 | 中国石油化工股份有限公司 | Solid phase extracting device |
| CN106345142B (en) * | 2015-07-13 | 2018-12-21 | 中国石油化工股份有限公司 | A kind of solid-phase extraction device |
| CN106018613A (en) * | 2016-06-23 | 2016-10-12 | 西安交通大学 | Solid-phase extraction device capable of realizing multi-column series connection through online switching and extraction method of solid-phase extraction device |
| CN106908513A (en) * | 2017-03-09 | 2017-06-30 | 浙江大学 | It is a kind of for 96 hole high flux solid-phase extraction devices of mass spectral analysis and its application |
| CN106908513B (en) * | 2017-03-09 | 2019-08-06 | 杭州汇健科技有限公司 | It is a kind of for 96 hole high throughput solid-phase extraction devices of mass spectral analysis and its application |
| CN108226357A (en) * | 2018-02-01 | 2018-06-29 | 南京信息工程大学 | A kind of device for eluting DNPH sampling columns |
| CN109646997A (en) * | 2019-01-08 | 2019-04-19 | 成都理工大学 | A kind of parallel automatic solid-phase extractor of corrosion-resistant multi-channel |
| CN109646997B (en) * | 2019-01-08 | 2020-06-02 | 成都理工大学 | Corrosion-resistant multi-channel parallel automatic solid phase extraction instrument |
| CN110927298A (en) * | 2019-11-20 | 2020-03-27 | 西安交通大学医学院第二附属医院 | Device capable of processing multiple samples at one time |
| CN111643928A (en) * | 2020-06-12 | 2020-09-11 | 中国地质大学（武汉） | Automatic solid phase extraction device |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20141126 Termination date: 20150313 |
|
| EXPY | Termination of patent right or utility model |