CN207384906U - A kind of chromatographic apparatus for extraction cannabidiol in industrial hemp - Google Patents
A kind of chromatographic apparatus for extraction cannabidiol in industrial hemp Download PDFInfo
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- CN207384906U CN207384906U CN201721392444.XU CN201721392444U CN207384906U CN 207384906 U CN207384906 U CN 207384906U CN 201721392444 U CN201721392444 U CN 201721392444U CN 207384906 U CN207384906 U CN 207384906U
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Abstract
The utility model discloses a kind of for extracting the chromatographic apparatus of cannabidiol in industrial hemp, the chromatographic apparatus includes liquid dispensing device, chromatographic column and controller, the liquid dispensing device includes mobile phase A storage tank, Mobile phase B storage tank, blending tank, liquid feeding tank, the mobile phase A storage tank, Mobile phase B storage tank is connected with blending tank, flow control valve A is provided between the mobile phase A storage tank and blending tank, flow control valve B is provided between the Mobile phase B storage tank and blending tank, agitating device is provided in the blending tank, the liquid feeding tank is arranged on the lower section of blending tank, strength of fluid sensor is provided in the liquid feeding tank, the controller electrical connection strength of fluid sensor, flow control valve A and flow control valve B；By delivery pump liquid feeding between the liquid feeding tank and chromatographic column, the chromatographic column includes inlet, cylinder and liquid outlet, and liquid stream distributor is provided with below the inlet.
Description
Technical field
The utility model belongs to separating-purifying equipment technical field, and in particular to one kind is used to extract hemp in industrial hemp
The chromatographic apparatus of diphenol.
Background technology
Cannabidiol（CBD）It is a kind of extracted from industrial hemp nontoxic, edible and with medical value
The aldehydes matter of high added value is the non-habituation ingredient in hemp, and THC can be hindered to influence nerve system of human body, and with anti-
The pharmacological activity such as spasm, resisting rheumatoid arthritis, antianxiety.Chromatographic technique is separative efficiency in the fields such as current pharmacy, chemical industry
One of the important means of one of highest method and Separation of Natural Products and other high purity substance preparative separations.
The cannabidiol medicinal extract of coarse extraction is included there are many chemical composition, including many of which unknown chemical ingredient, because
This, using being subject to many limitations.It is to obtain the first choice of high-purity C BD to carry out purifying using thin layer chromatography technology, but existing
For tomography devices also there are problems, such as existing chromatographic apparatus, a part is using manually progress liquid feeding, is not only added to
This, and since the chromatography cycle is long, needs long-time contact eluent, damages health mostly, and a part uses matches somebody with somebody in advance
Good eluent carries out liquid feeding, but due to the presence for the factors such as evaporate so that elution liquid proportional is difficult to keep constant, and
And substantial amounts of eluent is pre-configured with, it is difficult to adjust the proportioning of eluent in chromatography process at any time according to actual conditions, once
Adjustment proportioning, a large amount of pre-assigned eluents cancel can just reuse, it is necessary to re-start and recycle, time-consuming and laborious.Meanwhile
In chromatography process, it is easy to cause dry column phenomenon due to liquid equipment failure, directly contribute chromatography failure.And existing stream
There is no set mixing arrangement between dynamic phase so that mixes uneven between mobile phase, when being eluted, eluant, eluent ratio differs
It causes, also be easy to cause the failure of chromatography.
Therefore, it is necessary to develop a kind of chromatographic apparatus for extraction cannabidiol in industrial hemp.
Utility model content
The purpose of this utility model is to provide a kind of for extracting the chromatographic apparatus of cannabidiol in industrial hemp.
The purpose of this utility model is achieved in that the chromatographic apparatus includes liquid dispensing device, chromatographic column and control
Device, the liquid dispensing device include mobile phase A storage tank, Mobile phase B storage tank, blending tank, liquid feeding tank, the mobile phase A storage tank,
Mobile phase B storage tank is connected with blending tank, and flow control valve A is provided between the mobile phase A storage tank and blending tank, described
Mobile phase B storage tank and blending tank between be provided with flow control valve B, be provided with agitating device in the blending tank, it is described
Liquid feeding tank be arranged on the lower section of blending tank, strength of fluid sensor, controller electricity are provided in the liquid feeding tank
Connect strength of fluid sensor, flow control valve A and flow control valve B；Pass through conveying between the liquid feeding tank and chromatographic column
Liquid feeding is pumped, the chromatographic column includes inlet, cylinder and liquid outlet, liquid stream distributor is provided with below the inlet.
Compared with prior art, the utility model has following technique effect：
1st, mobile phase is sufficiently mixed in blending tank by the utility model by agitating device, and control in real time so that
Eluent proportioning in liquid feeding tank is stablized, and improves the stability of chromatography process；Meanwhile the utility model can also according to chromatograph into
Journey adjusts the proportioning of eluent at any time, avoids a variety of drawbacks for matching somebody with somebody liquid in advance in the prior art, separative efficiency is high, time saving province
Power.
2nd, the utility model below the inlet of chromatographic column by setting liquid stream distributor so that eluent distribution is equal
Even, stable operation effectively improves separative efficiency；By the setting of warning device, avoided column in the process due to liquid equipment event
Dry column phenomenon caused by barrier effectively improved the success rate of column, convenient for the separation of product.
3rd, the utility model using it is multiple connect flow container cycle carry out connecing liquid, substantially reduce separation after high-purity cannabidiol
With the possibility of impurity compound, separative efficiency is effectively improved, convenient for directly obtaining the product of high-purity, while convenient for single flowing
Mutually rush recycling during column, simplify technique, reduce cost.
4th, the setting that the utility model passes through blending tank so that be uniformly mixed between mobile phase, substantially increase chromatography
Success rate.
5th, the stainless steel column body of the utility model can adapt to industrial needs, while the presence of visual window is convenient for real
When observe chromatographic column cylinder situation, when in cylinder filler there is bubble, tomography when can find and adjust in time, just
In the control of chromatography process.
6th, the utility model is simple in structure, and obtained product purity is high, and quality is good, and realizes to a certain extent automatic
Change, also greatly reduce cost of labor, environmental protection and energy saving use convenient for extension.
Description of the drawings
Fig. 1 is the structure diagram of the utility model；
Fig. 2 is the principle schematic of the utility model；
In figure：1- mobile phase As storage tank, 2- Mobile phase Bs storage tank, 3- blending tanks, 4- liquid feedings tank, 5- chromatographic columns, 6- flow controls
Valve A, 7- flow control valve B, 8- agitating device processed, 9- strength of fluids sensor, 10- liquid streams distributor, 11- liquid level sensors.
Specific embodiment
The utility model will be further described below with reference to the accompanying drawings, but the utility model is not subject in any way
Limitation based on any conversion or replacement that the utility model training centre is made, belongs to the scope of protection of the utility model.
As attached drawing 1 ~ chromatographic apparatus shown in Fig. 2 includes liquid dispensing device, chromatographic column 5 and controller, the liquid dispensing device
Including mobile phase A storage tank 1, Mobile phase B storage tank 2, blending tank 3, liquid feeding tank 4, the mobile phase A storage tank 1, Mobile phase B storage tank 2
It is connected with blending tank 3, flow control valve A6, the flowing is provided between the mobile phase A storage tank 1 and blending tank 3
Flow control valve B7 is provided between phase B storage tanks 2 and blending tank 3, agitating device 8 is provided in the blending tank 3, it is described
Liquid feeding tank 4 is arranged on the lower section of blending tank 3, and strength of fluid sensor 9, the controller are provided in the liquid feeding tank 4
It is electrically connected strength of fluid sensor 9, flow control valve A6 and flow control valve B7；Lead between the liquid feeding tank 4 and chromatographic column 5
Delivery pump liquid feeding is crossed, the chromatographic column 5 includes inlet, cylinder and liquid outlet, liquid stream is provided with below the inlet
Distributor 10.
Warning device is provided in the liquid feeding tank 4, the warning device includes the liquid level being arranged in liquid feeding tank 4
Sensor 11 and the alarm being arranged on outside liquid feeding tank 4, the liquid level sensor 11 and alarm also with the controller
Electrical connection.
The controller is PLC controller.
The liquid stream distributor 10 is atomizing liquid stream distributor.
The filler of the cylinder of the chromatographic column 5 is silica gel or macroporous absorbent resin.
The cylinder of the chromatographic column 5 is stainless steel cylinder, and is provided with visual window on the cylinder.
The cylinder of the chromatographic column 5 is provided outside temperature control chuck.
The liquid outlet of the chromatographic column 5 is connected with 2 ~ 8 and connects flow container.
The flow container that connects is connected to centrifugal scraper plate thin film concentrator.
The delivery pump is industrial peristaltic pump.
Utility model works principle and the course of work：After the dress column absorption of cannabidiol crude extract sample, first lead to
It crosses controller and adjusts flow control valve A6 and flow control valve B7, use mobile phase A（It is used in the chromatography process of cannabidiol
Purified water）5 a period of time of chromatographic column is rinsed, then proceeds by elution, controller is first passed through and adjusts flow control valve A6 and stream
Flowing in mobile phase A storage tank 1 and Mobile phase B storage tank 2 is added in blending tank 3 by control valve B7, and by mobile phase A
（It is purified water in the chromatography process of cannabidiol）And Mobile phase B（It is ethyl alcohol in the chromatography process of cannabidiol）It is filled by stirring
It puts 8 to be sufficiently mixed to obtain the homogeneous eluent of concentration, the eluent after being sufficiently mixed enters liquid feeding tank 4, passes through liquid
Concentration sensor 9 detects strength of fluid, and feeds back to controller, in real time flow control valve A6 and flow control valve B7 is controlled to cause
Eluent proportioning in liquid feeding tank 4 is stablized；Moreover, the utility model also can adjust matching somebody with somebody for eluent at any time according to chromatography process
Than；By setting liquid stream distributor 10 below the inlet of chromatographic column 5 so that eluent is evenly distributed, stable operation, effectively
Improve separative efficiency.
Further, when the signal of liquid level sensor 11 in chromatography process is less than preset value, controller control alarm
It alarms, avoids dry column phenomenon, the success rate of column was effectively improved, convenient for the separation of product.
Further, the utility model can select PLC controller.
Further, the utility model is connect flow container cycle and is carried out connecing liquid using multiple, when using single mobile phase（Such as purifying
Water）It when rushing column, is no longer handled after directly connecing liquid, simplifies technique, reduce cost；And multiple flow containers that connect separately connect liquid, greatly
The big high-purity cannabidiol reduced after separating and the possibility of impurity compound, effectively improve separative efficiency, convenient for directly obtaining
The product of high-purity.
Further, the cylinder of chromatographic column 5 is stainless steel cylinder, and visual window is provided on cylinder；Stainless steel column physical efficiency
Enough adapt to industrial needs, at the same visual window there is a situation where convenient for Real Time Observation cylinder, filler in cylinder is avoided to go out
It can not find and adjust in time when existing bubble, tomography.
The utility model is easy to operate, realizes automation, also greatly reduces cost of labor.
Claims (10)
1. a kind of chromatographic apparatus for extraction cannabidiol in industrial hemp, it is characterised in that the chromatographic apparatus includes matching somebody with somebody
Liquid device, chromatographic column（5）And controller, the liquid dispensing device include mobile phase A storage tank（1）, Mobile phase B storage tank（2）, mixing
Tank（3）, liquid feeding tank（4）, the mobile phase A storage tank（1）, Mobile phase B storage tank（2）And blending tank（3）Connection, the stream
Dynamic phase A storage tanks（1）With blending tank（3）Between be provided with flow control valve A（6）, the Mobile phase B storage tank（2）With blending tank
（3）Between be provided with flow control valve B（7）, the blending tank（3）In be provided with agitating device（8）, the liquid feeding tank
（4）It is arranged on blending tank（3）Lower section, the liquid feeding tank（4）In be provided with strength of fluid sensor（9）, the control
Device is electrically connected strength of fluid sensor（9）, flow control valve A（6）With flow control valve B（7）；The liquid feeding tank（4）With layer
Analyse column（5）Between pass through delivery pump liquid feeding, the chromatographic column（5）Including inlet, cylinder and liquid outlet, the inlet
Lower section is provided with liquid stream distributor（10）.
2. the chromatographic apparatus according to claim 1 for extraction cannabidiol in industrial hemp, it is characterised in that described
Liquid feeding tank（4）In be provided with warning device, the warning device includes being arranged on liquid feeding tank（4）Interior liquid level sensor
（11）Be arranged on liquid feeding tank（4）Outer alarm, the liquid level sensor（11）With alarm also with the controller
Electrical connection.
3. the chromatographic apparatus according to claim 1 for extraction cannabidiol in industrial hemp, it is characterised in that described
Controller be PLC controller.
4. the chromatographic apparatus according to claim 1 for extraction cannabidiol in industrial hemp, it is characterised in that described
Liquid stream distributor（10）For atomizing liquid stream distributor.
5. the chromatographic apparatus according to claim 1 for extraction cannabidiol in industrial hemp, it is characterised in that described
Chromatographic column（5）Cylinder filler be silica gel or macroporous absorbent resin.
6. the chromatographic apparatus according to claim 1 for extraction cannabidiol in industrial hemp, it is characterised in that described
Chromatographic column（5）Cylinder for stainless steel cylinder, and be provided with visual window on the cylinder.
7. the chromatographic apparatus according to claim 1 for extraction cannabidiol in industrial hemp, it is characterised in that described
Chromatographic column（5）Cylinder be provided outside temperature control chuck.
8. the chromatographic apparatus according to claim 1 for extraction cannabidiol in industrial hemp, it is characterised in that described
Chromatographic column（5）Liquid outlet be connected with 2 ~ 8 and connect flow container.
9. the chromatographic apparatus according to claim 8 for extraction cannabidiol in industrial hemp, it is characterised in that described
The flow container that connects be connected to centrifugal scraper plate thin film concentrator.
10. the chromatographic apparatus according to claim 1 for extraction cannabidiol in industrial hemp, it is characterised in that described
Delivery pump be industrial peristaltic pump.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721392444.XU CN207384906U (en) | 2017-10-26 | 2017-10-26 | A kind of chromatographic apparatus for extraction cannabidiol in industrial hemp |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721392444.XU CN207384906U (en) | 2017-10-26 | 2017-10-26 | A kind of chromatographic apparatus for extraction cannabidiol in industrial hemp |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207384906U true CN207384906U (en) | 2018-05-22 |
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ID=62330351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201721392444.XU Active CN207384906U (en) | 2017-10-26 | 2017-10-26 | A kind of chromatographic apparatus for extraction cannabidiol in industrial hemp |
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| CN (1) | CN207384906U (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110270134A (en) * | 2019-05-31 | 2019-09-24 | 江苏哈工药机科技股份有限公司 | A kind of high-purity C BD isolates and purifies device and its isolation and purification method |
| CN111729351A (en) * | 2020-07-29 | 2020-10-02 | 辽宁石化职业技术学院 | Novel automatic chromatographic separation purification device |
| US11040932B2 (en) | 2018-10-10 | 2021-06-22 | Treehouse Biotech, Inc. | Synthesis of cannabigerol |
| US11084770B2 (en) | 2016-12-07 | 2021-08-10 | Treehouse Biotech, Inc. | Cannabis extracts |
| US11202771B2 (en) | 2018-01-31 | 2021-12-21 | Treehouse Biotech, Inc. | Hemp powder |
-
2017
- 2017-10-26 CN CN201721392444.XU patent/CN207384906U/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11084770B2 (en) | 2016-12-07 | 2021-08-10 | Treehouse Biotech, Inc. | Cannabis extracts |
| US11202771B2 (en) | 2018-01-31 | 2021-12-21 | Treehouse Biotech, Inc. | Hemp powder |
| US11040932B2 (en) | 2018-10-10 | 2021-06-22 | Treehouse Biotech, Inc. | Synthesis of cannabigerol |
| CN110270134A (en) * | 2019-05-31 | 2019-09-24 | 江苏哈工药机科技股份有限公司 | A kind of high-purity C BD isolates and purifies device and its isolation and purification method |
| CN111729351A (en) * | 2020-07-29 | 2020-10-02 | 辽宁石化职业技术学院 | Novel automatic chromatographic separation purification device |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Yunnan Hanmeng Pharmaceutical Co., Ltd Assignor: Yunnan Hansu bio-technology Co.,Ltd. Contract record no.: X2020980001712 Denomination of utility model: A chromatographic device for draw cannabidiol among industrial hemp Granted publication date: 20180522 License type: Common License Record date: 20200423 |
|
| EE01 | Entry into force of recordation of patent licensing contract |