CN203170059U - Column chromatography device with alarm function - Google Patents
Column chromatography device with alarm function Download PDFInfo
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- CN203170059U CN203170059U CN 201320158175 CN201320158175U CN203170059U CN 203170059 U CN203170059 U CN 203170059U CN 201320158175 CN201320158175 CN 201320158175 CN 201320158175 U CN201320158175 U CN 201320158175U CN 203170059 U CN203170059 U CN 203170059U
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- column chromatography
- chromatography device
- upper cover
- warning function
- liquid
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Abstract
The utility mode provides a column chromatography device with an alarm function. The device is used for solving the problem that conventional chromatography devices are incapable of alarming when liquid is too much or too little. The device comprises a column, an upper seal head, a lower seal head and a liquid level alarm, wherein fillers are filled in the column; a filler inlet and filler outlet are formed on the column; the upper seal head is arranged at the upper end of the column; a liquid inlet, an exhaust port and a backwash liquid outlet are formed on the upper seal head; the lower seal head is arranged at the lower end of the column; a liquid outlet is formed on the lower seal head; the liquid level alarm is arranged on the upper seal head; and the column is fixedly connected with the upper seal head and the lower seal head. The column chromatography device with the alarm function, provided by the utility model, is capable of providing an alarm function when the liquid is too much or too little and nobody watches through the liquid level alarm; and the column chromatography device is simple in structure, convenient in operation, low in equipment cost and suitable for commercial popularization and application.
Description
Technical field
The utility model relates to the purifies and separates chromatographic apparatus that use in fields such as a kind of pharmacy, food, chemical industry, refers to a kind of column chromatography device with warning function especially.
Background technology
The column chromatography conduct is one of method for purifying and separating efficiently, has been widely used in the purifies and separates of natural products and synthetic product.Patent 200520050126.6 has proposed a kind of insulation rapid column chromatography separator, utilizes the recirculated water of uniform temperature to be incubated, and has improved the separating effect of mixture; Patent 201110077072.2 has proposed a kind of column chromatography for separation device, comprise: soccer star's condenser pipe, serpentine condenser, chromatographic column, reaction vessel and heater, the junction of used unit all adopts ground to connect, and the working environment of sealing has not only reduced solvent loss but also avoided environmental pollution.But existing column chromatography device does not have the liquid level warning function, when unattended, occur the liquid material easily and too much causes the liquid material to overflow or the phenomenon of the very few appearance of liquid material " dried post ".
The utility model content
The utility model proposes a kind of column chromatography device with warning function, in order to solve the problem that existing column chromatography device liquid material can't be reported to the police when too much or very few.
The technical solution of the utility model is achieved in that
A kind of column chromatography device with warning function comprises: cylinder, be filled with filler in the cylinder, and cylinder is provided with filler import and filler outlet; Upper cover is arranged on the upper end of cylinder, and upper cover is provided with inlet, exhaust outlet and backwash liquor outlet; Low head is arranged on the lower end of cylinder, and low head is provided with liquid outlet; Liquid level alarm is arranged on the upper cover; Cylinder is fixedlyed connected with upper cover, low head.
As a kind of optimized technical scheme, also be provided with temperature control circulating water intake and temperature control circulating water outlet on the cylinder.
As to improvement of the technical scheme, the first punching sieve plate and first seal washer are installed between cylinder and the upper cover; The second punching sieve plate and second seal washer are installed between cylinder and the low head.
As a kind of optimized technical scheme, liquid level alarm is the Fibre Optical Sensor liquid level alarm.
As a kind of optimized technical scheme, also be provided with on the upper cover for the pressure-reduction outlet that connects vacuum line and the pressurization mouth that is used for being connected pressurized equipment.
As a kind of optimized technical scheme, filler is one or more in macroreticular resin, ion exchange resin and the polyamide.
As another improvement to technique scheme, also be provided with thermometer, vacuum meter and Pressure gauge on the upper cover.
As the another improvement to technique scheme, also comprise the liquid distribution trough and the flowmeter that are arranged on the inlet place.
As a kind of optimized technical scheme, liquid distribution trough is the spray nozzle type liquid distribution trough.
As a kind of optimized technical scheme, fixedly connected by first flange between cylinder and the upper cover; Fixedly connected by second flange between cylinder and the low head.
Owing to adopted technique scheme, a kind of column chromatography device with warning function comprises: cylinder, cylinder are provided with filler import and filler outlet; Upper cover is arranged on the upper end of cylinder, and upper cover is provided with inlet, exhaust outlet and backwash liquor outlet; Low head is arranged on the lower end of cylinder, and low head is provided with liquid outlet; Liquid level alarm is arranged on the upper cover; Cylinder is fixedlyed connected with upper cover, low head, by liquid level alarm is set, and can be to the too much or very few warning function that provides of liquid material when unattended column chromatography device.
The utility model can be to the too much or very few warning function that provides of liquid material when unattended column chromatography device by liquid level alarm is set.In addition, the utility model can also effectively be controlled the temperature of column chromatography device, has improved the utilization rate of separation and purification of products effect and filler, and is rational in infrastructure, easy to operate and equipment cost is low, is fit to business promotion and uses.
Description of drawings
In order to be illustrated more clearly in the utility model embodiment or technical scheme of the prior art, to do to introduce simply to the accompanying drawing of required use in embodiment or the description of the Prior Art below, apparently, accompanying drawing in describing below only is embodiment more of the present utility model, for those of ordinary skills, under the prerequisite of not paying creative work, can also obtain other accompanying drawing according to these accompanying drawings.
Fig. 1 is a kind of planar structure schematic diagram with column chromatography device of warning function of the utility model;
Fig. 2 is the planar structure schematic diagram of this column chromatography device upper cover part;
Fig. 3 is the punching sieve plate of this column chromatography device and the planar structure schematic diagram of sealing ring.
1, cylinder; 2, upper cover; 3, low head; 4, first flange; 5, second flange; 6, the first punching sieve plate; 7, the second punching sieve plate; 8, first seal washer; 9, second seal washer; 10, temperature control circulating water outlet; 11, temperature control circulating water intake; 12, filler outlet; 13, filler import; 14, Fibre Optical Sensor liquid level alarm; 15, inlet; 16, spray nozzle type liquid distribution trough; 17, exhaust outlet; 18, backwash liquor outlet; 19, thermometer; 20, vacuum meter; 21, Pressure gauge; 22, pressurization mouth; 23, pressure-reduction outlet; 24, flowmeter; 25, liquid outlet.
The specific embodiment
Below in conjunction with the accompanying drawing among the utility model embodiment, the technical scheme among the utility model embodiment is clearly and completely described, obviously, described embodiment only is the utility model part embodiment, rather than whole embodiment.Based on the embodiment in the utility model, those of ordinary skills are not making the every other embodiment that obtains under the creative work prerequisite, all belong to the scope of the utility model protection.
Shown in Fig. 1, Fig. 2, Fig. 3 were common: a kind of column chromatography device with warning function comprised: cylinder 1, be filled with filler in the cylinder 1, and cylinder 1 is provided with filler import 13 and filler outlet 12; Upper cover 2 is arranged on the upper end of cylinder 1, and upper cover 2 is provided with inlet 15, exhaust outlet 17 and backwash liquor outlet 18; Low head 3 is arranged on the lower end of cylinder 1, and low head 3 is provided with liquid outlet 25; Liquid level alarm 14 is arranged on the upper cover 2; Cylinder 1 is fixedlyed connected with upper cover 2, low head 3.
By liquid level alarm 14 is installed, when the feed liquor amount was too much or very few, column chromatography device can send warning, and leakage and very few " the dried post " that causes of liquid material of avoiding the liquid material too much to cause have improved operating efficiency; The top of cylinder 1, below are respectively arranged with filler import 11 and the filler outlet 12 of band valve, and charging, discharging and regeneration are convenient, have reduced manipulation strength, have improved operating efficiency, and have improved to a certain extent the service life of filler.
Preferably, also be provided with temperature control circulating water intake 11 and temperature control circulating water outlet 12 on the cylinder 1.
The utility model is introduced temperature control recirculated water by temperature control circulating water intake 11, the temperature of control device preferably, reduced the temperature fluctuation of whole system, thereby satisfied to greatest extent in absorption, the separation process because the requirement of heat release, endothermic reaction stack temperature.
Preferably, the first punching sieve plate 6 and first seal washer 8 are installed between cylinder 1 and the upper cover 2, the second punching sieve plate 7 and second seal washer 9 are installed between cylinder 1 and the low head 3.
The filter element of existing column chromatography device mostly is plain gauze, quartz sand filter screen and core filter screen greatly.Plain gauze is dislocation distortion easily under high pressure, causes filler to be revealed; Quartz sand filter screen and core filter screen result in blockage easily when using and clean loaded down with trivial details.Filter element of the present utility model adopts punching sieve plate (preferred accurate punching sieve plate), filter hold back effective, voltage endurance capability strong, dismounting is cleaned simply, the auxiliary punching sieve plate of seal washer is installed, and makes the filter element highly efficient durable.
Preferably, liquid level alarm 14 is Fibre Optical Sensor liquid level alarm 14.
Preferably, also be provided with on the upper cover 2 for the pressure-reduction outlet 23 that connects vacuum line and the pressurization mouth 22 that is used for being connected pressurized equipment.
Preferably, filler is: one or more in macroreticular resin, ion exchange resin and the polyamide.
Preferably, also be provided with thermometer 19, vacuum meter 20 and Pressure gauge 21 on the upper cover 2.
Preferably, also comprise liquid distribution trough 16 and the flowmeter 24 that is arranged on inlet 15 places.
Preferably, liquid distribution trough 16 is spray nozzle type liquid distribution trough 16.
Below the inlet 15 on the upper cover 2 spray nozzle type liquid distribution trough 16 is set, can allows feed liquid disperse to greatest extent, dispersed feed liquid is through the distribution again of the first punching sieve plate 6, and the distributing homogeneity of liquid material is higher, makes things convenient for separation and purification.
Preferably, fixedly connected by first flange 4 between cylinder 1 and the upper cover 2, fixedly connected by second flange 5 between cylinder 1 and the low head 3.
The utility model can be to the too much or very few warning function that provides of liquid material when unattended column chromatography device by liquid level alarm is set.In addition, the utility model can also effectively be controlled the temperature of column chromatography device, has improved the utilization rate of separation and purification of products effect and filler, and is rational in infrastructure, easy to operate and equipment cost is low, is fit to business promotion and uses.
Embodiment 1:
The column chromatography device that the utility model proposes is used with feed liquid basin, heat exchanger, insulation heating basin.
During washing lotion: at first feed liquid is entered by the feed liquid basin and carry out preheating in the heat exchanger, the feed liquid after the preheating is kept in the insulation heating basin; During charging, feed liquid enters column chromatography device from insulation heating basin through inlet 15, spray nozzle type liquid distribution trough 16, the pressure-reduction outlet 23 in the column chromatography device and vacuum line will be connected before the charging; The feed liquid of being disperseed by spray nozzle type liquid distribution trough 16 is again through the distribution again of the first punching sieve plate 6, evenly through macroreticular resin, separated object is inhaled parsing on macroreticular resin, the eluent of impurity and heterogeneity moves down respectively, flow into low head 3 by the second punching sieve plate 7, flow out column chromatography device via liquid outlet 25 again.
When backwash or regeneration: liquid enters column chromatography device from the liquid outlet 25 on the low head 3, and macroreticular resin is washed away, and the macroreticular resin of rise is held back by the first punching sieve plate 6, and gas, backwash liquor, regenerated liquid are discharged through the inlet 15 of upper cover 2.
When unloading macroreticular resin, open feeding port outlet 12, macroreticular resin can flow out in self gravitation effect or outer the depressing of a bit.
The utility model can be to the too much or very few warning function that provides of liquid material when unattended column chromatography device by liquid level alarm is set.In addition, the utility model can also effectively be controlled the temperature of column chromatography device, has improved the utilization rate of separation and purification of products effect and filler, and is rational in infrastructure, easy to operate and equipment cost is low, is fit to business promotion and uses.
Embodiment 2:
The column chromatography device that the utility model proposes is used with feed liquid basin, heat exchanger, insulation heating basin.
During washing lotion: at first feed liquid is entered by the feed liquid basin and carry out preheating in the heat exchanger, the feed liquid after the preheating is kept in the insulation heating basin; During charging, feed liquid enters column chromatography device from insulation heating basin through inlet 15, spray nozzle type liquid distribution trough 16, the pressurization mouth 22 in the column chromatography device and pressurized equipment will be connected before the charging; Dispersed feed liquid is again through the distribution again of the first punching sieve plate 6, evenly through ion exchange resin, separated object is inhaled parsing on ion exchange resin, the eluent of impurity and heterogeneity moves down respectively, flow into low head 3 by the second punching sieve plate 7, flow out column chromatography device via liquid outlet 25 again.
When backwash or regeneration: liquid enters column chromatography device from the liquid outlet 25 on the low head 3, and ion exchange resin is washed away, and the ion exchange resin of rise is held back by the first punching sieve plate 6, and gas, backwash liquor, regenerated liquid are discharged through the inlet 15 of upper cover 2.
When unloading subtree fat, open feeding port outlet 12, ion exchange resin can flow out in self gravitation effect or outer the depressing of a bit.
The utility model can be to the too much or very few warning function that provides of liquid material when unattended column chromatography device by liquid level alarm is set.In addition, the utility model can also effectively be controlled the temperature of column chromatography device, has improved the utilization rate of separation and purification of products effect and filler, and is rational in infrastructure, easy to operate and equipment cost is low, is fit to business promotion and uses.
Embodiment 3:
The column chromatography device that the utility model proposes is used with feed liquid basin, heat exchanger, insulation heating basin.
During washing lotion: at first feed liquid is entered by the feed liquid basin and carry out preheating in the heat exchanger, the feed liquid after the preheating is kept in the insulation heating basin; During charging, feed liquid enters column chromatography device from insulation heating basin through inlet 15, spray nozzle type liquid distribution trough 16, the pressure-reduction outlet 23 in the column chromatography device and vacuum line will be connected before the charging; Dispersed feed liquid is again through the distribution again of the first punching sieve plate 6, evenly through polyamide, separated object is inhaled parsing on polyamide, the eluent of impurity and heterogeneity moves down respectively, flow into low head 3 by the second punching sieve plate 7, flow out column chromatography device via liquid outlet 25 again.
When backwash or regeneration: liquid enters column chromatography device from the liquid outlet 25 on the low head 3, and polyamide is washed away, and the polyamide of rise is held back by the first punching sieve plate 6, and gas, backwash liquor, regenerated liquid are discharged through the inlet 15 of upper cover 2.
When unloading polyamide, open feeding port outlet 12, polyamide can flow out in self gravitation effect or outer the depressing of a bit.
The utility model is by arranging liquid level alarm, can be when unattended to the liquid material the too much or very few warning function that provides, reduced manipulation strength, improved operating efficiency.In addition, the utility model can effectively be controlled the temperature of column chromatography device by introducing temperature control recirculated water, has improved the separation and purification effect.Rational in infrastructure, the easy to operate and equipment cost of the utility model is fit to business promotion and uses.
Below only be preferred embodiment of the present utility model, in order to limit the utility model, not all within spirit of the present utility model and principle, any modification of doing, be equal to replacement, improvement etc., all should be included within the protection domain of the present utility model.
Claims (10)
1. the column chromatography device with warning function is characterized in that, comprising:
Cylinder (1), described cylinder is filled with filler in (1), and described cylinder (1) is provided with filler import (13) and filler outlet (12);
Upper cover (2) is arranged on the upper end of described cylinder (1), and described upper cover (2) is provided with inlet (15), exhaust outlet (17) and backwash liquor outlet (18);
Low head (3) is arranged on the lower end of described cylinder (1), and described low head (3) is provided with liquid outlet (25);
Liquid level alarm (14) is arranged on the described upper cover (2);
Described cylinder (1) is fixedlyed connected with described upper cover (2), described low head (3).
2. the column chromatography device with warning function according to claim 1 is characterized in that: also be provided with temperature control circulating water intake (11) and temperature control circulating water outlet (12) on the described cylinder (1).
3. the column chromatography device with warning function according to claim 1 is characterized in that:
The first punching sieve plate (6) and first seal washer (8) are installed between described cylinder (1) and the described upper cover (2);
The second punching sieve plate (7) and second seal washer (9) are installed between described cylinder (1) and the described low head (3).
4. the column chromatography device with warning function according to claim 1, it is characterized in that: described liquid level alarm (14) is Fibre Optical Sensor liquid level alarm (14).
5. the column chromatography device with warning function according to claim 1 is characterized in that: also be provided with on the described upper cover (2) for the pressure-reduction outlet (23) that connects vacuum line and the pressurization mouth (22) that is used for being connected pressurized equipment.
6. the column chromatography device with warning function according to claim 1, it is characterized in that: described filler is: one or more in macroreticular resin, ion exchange resin and the polyamide.
7. the column chromatography device with warning function according to claim 1 is characterized in that: also be provided with thermometer (19), vacuum meter (20) and Pressure gauge (21) on the described upper cover (2).
8. the column chromatography device with warning function according to claim 7 is characterized in that: also comprise being arranged on liquid distribution trough (16) and the flowmeter (24) that described inlet (15) is located.
9. the column chromatography device with warning function according to claim 8, it is characterized in that: described liquid distribution trough (16) is spray nozzle type liquid distribution trough (16).
10. according to each described column chromatography device with warning function of claim 1-9, it is characterized in that: fixedly connected by first flange (4) between described cylinder (1) and the described upper cover (2), fixedly connected by second flange (5) between described cylinder (1) and the described low head (3).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201320158175 CN203170059U (en) | 2013-04-01 | 2013-04-01 | Column chromatography device with alarm function |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201320158175 CN203170059U (en) | 2013-04-01 | 2013-04-01 | Column chromatography device with alarm function |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203170059U true CN203170059U (en) | 2013-09-04 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201320158175 Expired - Fee Related CN203170059U (en) | 2013-04-01 | 2013-04-01 | Column chromatography device with alarm function |
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| Country | Link |
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| CN (1) | CN203170059U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103191585A (en) * | 2013-04-01 | 2013-07-10 | 田景振 | Column chromatography device with warning function |
| CN104307205A (en) * | 2014-11-12 | 2015-01-28 | 成都彼斯特生物科技有限公司 | Macroporous resin adsorption-separation device |
-
2013
- 2013-04-01 CN CN 201320158175 patent/CN203170059U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103191585A (en) * | 2013-04-01 | 2013-07-10 | 田景振 | Column chromatography device with warning function |
| CN104307205A (en) * | 2014-11-12 | 2015-01-28 | 成都彼斯特生物科技有限公司 | Macroporous resin adsorption-separation device |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130904 Termination date: 20160401 |
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| CF01 | Termination of patent right due to non-payment of annual fee |