CN103191585B - A kind of column chromatography device with warning function - Google Patents
A kind of column chromatography device with warning function Download PDFInfo
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- CN103191585B CN103191585B CN201310111383.5A CN201310111383A CN103191585B CN 103191585 B CN103191585 B CN 103191585B CN 201310111383 A CN201310111383 A CN 201310111383A CN 103191585 B CN103191585 B CN 103191585B
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Abstract
The present invention proposes a kind of column chromatography device with warning function, solve existing column chromatography device liquid material too much or very few time the problem that cannot report to the police, comprising: cylinder, in cylinder, be filled with filler, cylinder is provided with filler import and filler outlet; Upper cover, is arranged on the upper end of cylinder, upper cover is provided with the outlet of inlet, exhaust outlet and backwash liquor; Low head, is arranged on the lower end of cylinder, low head is provided with liquid outlet; Liquid level alarm, is arranged on upper cover; Cylinder is fixedly connected with upper cover, low head.A kind of column chromatography device with warning function that the present invention proposes, by arranging liquid level alarm, can be too much or very fewly provide warning function to liquid material when unattended, rational in infrastructure, easy to operate and equipment cost is low, be applicable to business promotion application.
Description
Technical field
The present invention relates to the purifies and separates chromatographic apparatus of the field application such as a kind of pharmacy, food, chemical industry, refer to a kind of column chromatography device with warning function especially.
Background technology
Column chromatography, as one of efficient method for purifying and separating, has been widely used in the purifies and separates of natural products and synthetic product.Patent 200520050126.6 proposes a kind of thermal insulating rapid column chromatography separator, utilizes the recirculated water of uniform temperature to be incubated, improves the separating effect of mixture; Patent 201110077072.2 proposes a kind of column chromatography separating unit, comprise: soccer star's condenser pipe, serpentine condenser, chromatographic column, reaction vessel and heater, the junction of used unit all adopts ground to connect, and the working environment closed both had decreased solvent loss and turn avoid environmental pollution.But existing column chromatography device does not have liquid level warning function, when unattended, easily occur that liquid material too much causes the phenomenon of liquid material spilling or the very few appearance of liquid material " dry post ".
Summary of the invention
The present invention proposes a kind of column chromatography device with warning function, in order to solve existing column chromatography device liquid material too much or very few time the problem that cannot report to the police.
Technical scheme of the present invention is achieved in that
There is a column chromatography device for warning function, comprising: cylinder, in cylinder, be filled with filler, cylinder is provided with filler import and filler outlet; Upper cover, is arranged on the upper end of cylinder, upper cover is provided with the outlet of inlet, exhaust outlet and backwash liquor; Low head, is arranged on the lower end of cylinder, low head is provided with liquid outlet; Liquid level alarm, is arranged on upper cover; Cylinder is fixedly connected with upper cover, low head.
As the preferred technical scheme of one, cylinder is also provided with temperature control circulating water intake and temperature control circulating water outlet.
As the improvement to technique scheme, the first punching sieve plate and the first seal washer are installed between cylinder and upper cover; Second punching sieve plate and the second seal washer are installed between cylinder and low head.
As the preferred technical scheme of one, liquid level alarm is Fibre Optical Sensor liquid level alarm.
As the preferred technical scheme of one, upper cover is also provided with the pressure-reduction outlet for connecting vacuum line and the pressurization mouth for being connected pressurized equipment.
As the preferred technical scheme of one, filler is one or more in macroreticular resin, ion exchange resin and polyamide.
As another improvement to technique scheme, upper cover is also provided with thermometer, vacuum meter and Pressure gauge.
As the another improvement to technique scheme, also comprise the liquid distribution trough and flowmeter that are arranged on inlet place.
As the preferred technical scheme of one, liquid distribution trough is spray nozzle type liquid distribution trough.
As the preferred technical scheme of one, be fixedly connected with by the first flange between cylinder with upper cover; Be fixedly connected with by the second flange between cylinder with low head.
Owing to have employed technique scheme, a kind of column chromatography device with warning function, comprising: cylinder, cylinder is provided with filler import and filler outlet; Upper cover, is arranged on the upper end of cylinder, upper cover is provided with the outlet of inlet, exhaust outlet and backwash liquor; Low head, is arranged on the lower end of cylinder, low head is provided with liquid outlet; Liquid level alarm, is arranged on upper cover; Cylinder is fixedly connected with upper cover, low head, by arranging liquid level alarm, and can be too much or very fewly provide warning function to liquid material when unattended column chromatography device.
The present invention, can be too much or very fewly provide warning function to liquid material when unattended column chromatography device by arranging liquid level alarm.In addition, the present invention effectively can also control the temperature of column chromatography device, improves the utilization rate of separation and purification of products effect and filler, rational in infrastructure, easy to operate and equipment cost is low, is applicable to business promotion application.
Accompanying drawing explanation
In order to be illustrated more clearly in the embodiment of the present invention or technical scheme of the prior art, be briefly described to the accompanying drawing used required in embodiment or description of the prior art below, apparently, accompanying drawing in the following describes is only some embodiments of the present invention, for those of ordinary skill in the art, under the prerequisite not paying creative work, other accompanying drawing can also be obtained according to these accompanying drawings.
Fig. 1 is a kind of planar structure schematic diagram with the column chromatography device of warning function of the present invention;
Fig. 2 is the planar structure schematic diagram of this column chromatography device upper cover part;
Fig. 3 is the punching sieve plate of this column chromatography device and the planar structure schematic diagram of sealing ring.
1, cylinder; 2, upper cover; 3, low head; 4, the first flange; 5, the second flange; 6, the first punching sieve plate; 7, the second punching sieve plate; 8, the first seal washer; 9, the second seal washer; 10, temperature control circulating water outlet; 11, temperature control circulating water intake; 12, filler outlet; 13, filler import; 14, Fibre Optical Sensor liquid level alarm; 15, inlet; 16, spray nozzle type liquid distribution trough; 17, exhaust outlet; 18, backwash liquor outlet; 19, thermometer; 20, vacuum meter; 21, Pressure gauge; 22, pressurize mouth; 23, pressure-reduction outlet; 24, flowmeter; 25, liquid outlet.
Detailed description of the invention
Below in conjunction with the accompanying drawing in the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
As shown in Figure 1, Figure 2, Fig. 3 jointly shown in: a kind of column chromatography device with warning function, comprising: cylinder 1, is filled with filler in cylinder 1, cylinder 1 is provided with filler import 13 and filler outlet 12; Upper cover 2, is arranged on the upper end of cylinder 1, upper cover 2 is provided with inlet 15, exhaust outlet 17 and backwash liquor outlet 18; Low head 3, is arranged on the lower end of cylinder 1, low head 3 is provided with liquid outlet 25; Liquid level alarm 14, is arranged on upper cover 2; Cylinder 1 is fixedly connected with upper cover 2, low head 3.
By install liquid level alarm 14, when liquid inlet volume too much or very few time, column chromatography device can send warning, and the leakage avoiding liquid material too much to cause and very few " the dry post " caused of liquid material, improve operating efficiency; The top of cylinder 1, below are respectively arranged with filler import 11 and the filler outlet 12 of band valve, and charging, discharging and regeneration are convenient, reduce manipulation strength, improve operating efficiency, and improve the service life of filler to a certain extent.
Preferably, cylinder 1 is also provided with temperature control circulating water intake 11 and temperature control circulating water outlet 12.
The present invention introduces temperature control recirculated water by temperature control circulating water intake 11, and the temperature of the good control device of energy, decreases the temperature fluctuation of whole system, thus meet the requirement due to heat release, endothermic reaction stack temperature in absorption, separation process to greatest extent.
Preferably, the first punching sieve plate 6 and the first seal washer 8 is installed between cylinder 1 and upper cover 2, the second punching sieve plate 7 and the second seal washer 9 is installed between cylinder 1 and low head 3.
The filter element of existing column chromatography device is mostly plain gauze, quartz sand filter screen and core filter screen.Plain gauze under high pressure easily misplaces distortion, causes filler to be revealed; Quartz sand filter screen and core filter screen easily result in blockage and clean loaded down with trivial details when using.Filter element of the present invention adopts punching sieve plate (preferred precision punching sieve plate), and filtration rejection effect is good, voltage endurance capability strong, dismounting cleaning is simple, and seal washer assists punching sieve plate to install, and makes filter element highly efficient durable.
Preferably, liquid level alarm 14 is Fibre Optical Sensor liquid level alarm 14.
Preferably, upper cover 2 is also provided with the pressure-reduction outlet 23 for connecting vacuum line and the pressurization mouth 22 for being connected pressurized equipment.
Preferably, filler is: one or more in macroreticular resin, ion exchange resin and polyamide.
Preferably, upper cover 2 is also provided with thermometer 19, vacuum meter 20 and Pressure gauge 21.
Preferably, the liquid distribution trough 16 being arranged on inlet 15 place and flowmeter 24 is also comprised.
Preferably, liquid distribution trough 16 is spray nozzle type liquid distribution trough 16.
The below of the inlet 15 on upper cover 2 arranges spray nozzle type liquid distribution trough 16, and feed liquid can be allowed to disperse to greatest extent, and dispersed feed liquid is through the distribution again of the first punching sieve plate 6, and the distributing homogeneity of liquid material is higher, facilitates separation and purification.
Preferably, be fixedly connected with by the first flange 4 between cylinder 1 with upper cover 2, be fixedly connected with by the second flange 5 between cylinder 1 with low head 3.
The present invention, can be too much or very fewly provide warning function to liquid material when unattended column chromatography device by arranging liquid level alarm.In addition, the present invention effectively can also control the temperature of column chromatography device, improves the utilization rate of separation and purification of products effect and filler, rational in infrastructure, easy to operate and equipment cost is low, is applicable to business promotion application.
Embodiment 1:
The present invention propose column chromatography device, with feed liquid basin, heat exchanger, Heat preservation basin with the use of.
During washing lotion: first feed liquid entered in heat exchanger by feed liquid basin and carry out preheating, the feed liquid after preheating is kept in Heat preservation basin; During charging, feed liquid enters column chromatography device from Heat preservation basin through inlet 15, spray nozzle type liquid distribution trough 16, the pressure-reduction outlet 23 in column chromatography device will be connected with vacuum line before charging; The feed liquid of being disperseed by spray nozzle type liquid distribution trough 16 is again through the distribution again of the first punching sieve plate 6, evenly through macroreticular resin, separated object carries out suction and resolves on macroreticular resin, the eluent of impurity and heterogeneity moves down respectively, flow into low head 3 by the second punching sieve plate 7, then flow out column chromatography device via liquid outlet 25.
When backwash or regeneration: liquid enters column chromatography device from the liquid outlet 25 low head 3, is washed away by macroreticular resin, and the macroreticular resin of rise is retained by the first punching sieve plate 6, and gas, backwash liquor, regenerated liquid are discharged through the inlet 15 of upper cover 2.
When unloading macroreticular resin, open feeding port outlet 12, macroreticular resin can flow out in self gravitation effect or the outer pressure of a bit.
The present invention, can be too much or very fewly provide warning function to liquid material when unattended column chromatography device by arranging liquid level alarm.In addition, the present invention effectively can also control the temperature of column chromatography device, improves the utilization rate of separation and purification of products effect and filler, rational in infrastructure, easy to operate and equipment cost is low, is applicable to business promotion application.
Embodiment 2:
The present invention propose column chromatography device, with feed liquid basin, heat exchanger, Heat preservation basin with the use of.
During washing lotion: first feed liquid entered in heat exchanger by feed liquid basin and carry out preheating, the feed liquid after preheating is kept in Heat preservation basin; During charging, feed liquid enters column chromatography device from Heat preservation basin through inlet 15, spray nozzle type liquid distribution trough 16, the pressurization mouth 22 in column chromatography device will be connected with pressurized equipment before charging; The feed liquid of being disperseed by spray nozzle type liquid distribution trough 16 is again through the distribution again of the first punching sieve plate 6, evenly through ion exchange resin, separated object carries out suction and resolves on ion exchange resin, the eluent of impurity and heterogeneity moves down respectively, flow into low head 3 by the second punching sieve plate 7, then flow out column chromatography device via liquid outlet 25.
When backwash or regeneration: liquid enters column chromatography device from the liquid outlet 25 low head 3, is washed away by ion exchange resin, and the ion exchange resin of rise is retained by the first punching sieve plate 6, and gas, backwash liquor, regenerated liquid are discharged through the inlet 15 of upper cover 2.
When unloading ion exchange resin, open feeding port outlet 12, ion exchange resin can flow out in self gravitation effect or the outer pressure of a bit.
The present invention, can be too much or very fewly provide warning function to liquid material when unattended column chromatography device by arranging liquid level alarm.In addition, the present invention effectively can also control the temperature of column chromatography device, improves the utilization rate of separation and purification of products effect and filler, rational in infrastructure, easy to operate and equipment cost is low, is applicable to business promotion application.
Embodiment 3:
The present invention propose column chromatography device, with feed liquid basin, heat exchanger, Heat preservation basin with the use of.
During washing lotion: first feed liquid entered in heat exchanger by feed liquid basin and carry out preheating, the feed liquid after preheating is kept in Heat preservation basin; During charging, feed liquid enters column chromatography device from Heat preservation basin through inlet 15, spray nozzle type liquid distribution trough 16, the pressure-reduction outlet 23 in column chromatography device will be connected with vacuum line before charging; The feed liquid of being disperseed by spray nozzle type liquid distribution trough 16 is again through the distribution again of the first punching sieve plate 6, evenly through polyamide, separated object carries out suction and resolves on polyamide, the eluent of impurity and heterogeneity moves down respectively, flow into low head 3 by the second punching sieve plate 7, then flow out column chromatography device via liquid outlet 25.
When backwash or regeneration: liquid enters column chromatography device from the liquid outlet 25 low head 3, is washed away by polyamide, and the polyamide of rise is retained by the first punching sieve plate 6, and gas, backwash liquor, regenerated liquid are discharged through the inlet 15 of upper cover 2.
When unloading polyamide, open feeding port outlet 12, polyamide can flow out in self gravitation effect or the outer pressure of a bit.
The present invention, can be too much or very fewly provide warning function to liquid material when unattended by arranging liquid level alarm, reduces manipulation strength, improve operating efficiency.In addition, the present invention, by introducing temperature control recirculated water, effectively can control the temperature of column chromatography device, improve separation and purification effect.Rational in infrastructure, the easy to operate and equipment cost of the present invention, is applicable to business promotion application.
These are only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (5)
1. there is a column chromatography device for warning function, it is characterized in that, comprising:
Cylinder (1), described cylinder is filled with filler in (1), the upper end of described cylinder (1) is provided with filler import (13), and the bottom of described cylinder (1) is provided with filler outlet (12); Described cylinder (1) is provided with temperature control circulating water intake (11) and temperature control circulating water outlet (10);
Upper cover (2), is arranged on the upper end of described cylinder (1), described upper cover (2) is provided with inlet (15), exhaust outlet (17) and backwash liquor outlet (18); Described inlet (15) place is provided with liquid distribution trough (16) and flowmeter (24), and described liquid distribution trough (16) is spray nozzle type liquid distribution trough;
Low head (3), is arranged on the lower end of described cylinder (1), described low head (3) is provided with liquid outlet (25);
Liquid level alarm (14), is arranged on described upper cover (2), and described liquid level alarm (14) is Fibre Optical Sensor liquid level alarm;
Described cylinder (1) is fixedly connected with described upper cover (2), described low head (3), is provided with the first punching sieve plate (6) and the first seal washer (8) between described cylinder (1) and described upper cover (2);
Second punching sieve plate (7) and the second seal washer (9) are installed between described cylinder (1) and described low head (3).
2. the column chromatography device with warning function according to claim 1, is characterized in that: described upper cover (2) is also provided with the pressure-reduction outlet (23) for connecting vacuum line and the pressurization mouth (22) for being connected pressurized equipment.
3. the column chromatography device with warning function according to claim 1, is characterized in that: described filler is: one or more in macroreticular resin, ion exchange resin and polyamide.
4. the column chromatography device with warning function according to claim 1, is characterized in that: described upper cover (2) is also provided with thermometer (19), vacuum meter (20) and Pressure gauge (21).
5. the column chromatography device with warning function according to any one of claim 1-4, it is characterized in that: be fixedly connected with by the first flange (4) between described cylinder (1) with described upper cover (2), be fixedly connected with by the second flange (5) between described cylinder (1) with described low head (3).
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| CN201310111383.5A CN103191585B (en) | 2013-04-01 | 2013-04-01 | A kind of column chromatography device with warning function |
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| CN201310111383.5A CN103191585B (en) | 2013-04-01 | 2013-04-01 | A kind of column chromatography device with warning function |
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| CN103191585B true CN103191585B (en) | 2016-01-27 |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105327524B (en) * | 2014-08-08 | 2017-10-17 | 苏州汇通色谱分离纯化有限公司 | A kind of two ends contraction type in smoothing junction is high, middle pressure chromatographic column |
| CN106267890A (en) * | 2015-06-03 | 2017-01-04 | 中美华世通生物医药科技（武汉）有限公司 | Controllable compression tomographic system and chromatography method |
| CN105107229A (en) * | 2015-07-30 | 2015-12-02 | 杭州新博思生物医药有限公司 | Semi-automatic chromatography composite set in industrialize production |
| CN106807114A (en) * | 2015-11-30 | 2017-06-09 | 中美华世通生物医药科技（武汉）有限公司 | Taper chromatographic fractionation system and its method for isolating and purifying |
| CN109954296A (en) * | 2018-12-12 | 2019-07-02 | 江苏哈工药机科技股份有限公司 | A kind of anthocyanidin isolates and purifies device and isolation and purification method |
| CN110384951A (en) * | 2019-04-10 | 2019-10-29 | 江苏汉邦科技有限公司 | A kind of novel heat insulation chromatographic column |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101067619A (en) * | 2007-04-27 | 2007-11-07 | 浙江大学 | Malachite green fast detecting method and fast detecting kit |
| CN102059003A (en) * | 2011-01-17 | 2011-05-18 | 利穗科技(苏州)有限公司 | Visible fluorescence chromatographic column |
| CN202018318U (en) * | 2011-05-05 | 2011-10-26 | 中华人民共和国绍兴出入境检验检疫局 | Adjustable automatic solvent warning device |
| CN202700140U (en) * | 2012-07-23 | 2013-01-30 | 常州三泰科技有限公司 | Liquid chromatography column |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6387256B1 (en) * | 2000-07-10 | 2002-05-14 | Waters Investments Limited | Chromatography column |
| CN2770745Y (en) * | 2005-01-21 | 2006-04-12 | 谢碧霞 | Thermal insulating rapid column chromatography separator |
| CN2815464Y (en) * | 2005-08-27 | 2006-09-13 | 王柯 | Liquid-phase chromatographic fractionation column |
| CN201791397U (en) * | 2010-09-16 | 2011-04-13 | 花垣恒远植物生化有限责任公司 | Column chromatography separation device for plant effective ingredients |
| CN202289557U (en) * | 2011-10-24 | 2012-07-04 | 利穗科技(苏州)有限公司 | Rapid and dynamic compression chromatography column |
| CN203170059U (en) * | 2013-04-01 | 2013-09-04 | 田景振 | Column chromatography device with alarm function |
-
2013
- 2013-04-01 CN CN201310111383.5A patent/CN103191585B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101067619A (en) * | 2007-04-27 | 2007-11-07 | 浙江大学 | Malachite green fast detecting method and fast detecting kit |
| CN102059003A (en) * | 2011-01-17 | 2011-05-18 | 利穗科技(苏州)有限公司 | Visible fluorescence chromatographic column |
| CN202018318U (en) * | 2011-05-05 | 2011-10-26 | 中华人民共和国绍兴出入境检验检疫局 | Adjustable automatic solvent warning device |
| CN202700140U (en) * | 2012-07-23 | 2013-01-30 | 常州三泰科技有限公司 | Liquid chromatography column |
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