CN201249052Y - Full-automatic chromatographic separator set - Google Patents
Full-automatic chromatographic separator set Download PDFInfo
- Publication number
- CN201249052Y CN201249052Y CNU2008201621447U CN200820162144U CN201249052Y CN 201249052 Y CN201249052 Y CN 201249052Y CN U2008201621447 U CNU2008201621447 U CN U2008201621447U CN 200820162144 U CN200820162144 U CN 200820162144U CN 201249052 Y CN201249052 Y CN 201249052Y
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- storage tank
- chromatographic column
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- liquid storage
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- 238000003860 storage Methods 0.000 claims abstract description 61
- 239000007788 liquid Substances 0.000 claims abstract description 52
- 239000002904 solvent Substances 0.000 claims abstract description 29
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- 230000008676 import Effects 0.000 claims description 51
- 238000004587 chromatography analysis Methods 0.000 claims description 38
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 230000001172 regenerating effect Effects 0.000 abstract 2
- 238000000926 separation method Methods 0.000 description 10
- 239000012071 phase Substances 0.000 description 8
- 238000004440 column chromatography Methods 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 238000000746 purification Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000007791 liquid phase Substances 0.000 description 3
- 230000003321 amplification Effects 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000003199 nucleic acid amplification method Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 238000007600 charging Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 150000004053 quinones Chemical class 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- -1 steroidal Chemical class 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 238000002211 ultraviolet spectrum Methods 0.000 description 1
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- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
The utility model discloses a full-automatic chromatographic separator set which has high efficiency, simple operation and low cost, and easily achieves industrialized production, comprising a proportioning tank, a solvent storage tank, a diaphragm-metering pump, a buffer, pneumatic butterfly valves, a flow transmitter, a chromatographic post, a hand-operated valve, a chromatographic liquid storage tank, a regenerative liquid storage tank, a hot-water tank, a hot-water pump and a heat exchanger. The chromatographic separator set is characterized in that the proportioning tank and the solvent storage tank are connected with an intake of the diaphragm-metering pump by respective pneumatic butterfly valves, an outlet of the diaphragm-metering pump sequentially passes through the buffer, the pneumatic butterfly valves and the flow transmitter to be connected with the intake of the chromatographic post, the outlet of the chromatographic post sequentially passes through the hand-operated valve, the pneumatic butterfly valves and the flow transmitter to be respectively connected with the intake of the chromatographic liquid storage tank and the intake of the regenerative liquid storage tank, the outlet of the heat exchanger is connected with a jacket intake of the chromatographic post, a jacket outlet of the chromatographic post is connected with the intake of the hot-water tank, and the outlet of the hot-water tank is connected with the intake of the heat exchanger by the hot-water pump.
Description
Technical field
The utility model relates to a kind of liquid phase column chromatography for separation equipment that is suitable for the Chinese medicine refining effective ingredients, particularly a kind of full-automatic chromatography unit.
Background technology
The chromatography method claims chromatography again, be widely used in the separation and the purifying of native compound, its principle is to utilize the difference of each composition physicochemical properties in the mixture, make each composition be distributed in the two-phase to some extent, one of them is fixing phase, another makes each composition move with different speed in flow process, thereby reaches the purpose of separation and purification for the phase that flows.At present, most widely used in the separation and purification of middle pharmaceutically active ingredient is liquid column chromatography.The routine operation process is the fixing phase of filling in pillar equipment (chromatographic column), with separated mixture (traditional Chinese medicine extraction solution) displacement pile item, makes it be adsorbed on to fix and go up mutually.Feed eluting solvent (phase flows) then, with certain speed flushing, different components is successively come out by wash-out, collects and reclaim solvent respectively, has just finished the column chromatography for separation process.Since each component in the solution with fix mutually between the difference of affinity, at the bottom of each component can flow out post by weak and strong order successively by affinity, be that the more weak component of affinity goes out from the post underflow earlier, the component that affinity is stronger then flows out the back, thereby reaches the purpose of separation.Liquid column chromatography has a very wide range of applications in the separation and purification of the preparation of Chinese medicine plant reference substance and active component, and for example the separation and purification of active ingredients such as flavonoids, alkaloid, glycoside, phenols, aldehydes, amino acid, steroidal, terpene, quinones, organic acid, carbohydrate, ucleosides all needs to use the liquid phase column chromatography technology.In middle pharmaceutically active ingredient separation and purification, use more chromatography technology and mainly contain macroreticular resin chromatography technology, ion-exchange chromatography isolation technics, silica gel, aluminium oxide normal-phase chromatography, C18 reversed phase chromatography etc.Liquid phase column chromatography for separation equipment of the prior art all adopts manual operations, has defectives such as efficient is low, complicated operation, cost height, difficult realization suitability for industrialized production.
Summary of the invention
Technical problem to be solved in the utility model provide a kind of efficient height, simple to operate, cost is low, easily realize the full-automatic chromatography unit of suitability for industrialized production.
For solving the problems of the technologies described above, the utility model is by the following technical solutions: a kind of full-automatic chromatography unit, comprise material-compound tank, solvent tank, diaphragm metering pump, buffer, Pneumatic butterfly valve, flow transmitter, chromatographic column, hand-operated valve, the chromatographic solution storage tank, the regenerated liquid storage tank, hot-water cylinder, heat-exchanger pump, heat exchanger, material-compound tank and solvent tank are connected with the import of diaphragm metering pump by Pneumatic butterfly valve separately respectively, the metering diaphragm delivery side of pump passes through buffer successively, Pneumatic butterfly valve, flow transmitter is connected with the import of chromatographic column, hand-operated valve is passed through in the outlet of chromatographic column successively, Pneumatic butterfly valve, flow transmitter is connected with the import of chromatographic solution storage tank and the import of regenerated liquid storage tank respectively, the outlet of heat exchanger is connected with the chuck import of chromatographic column, the JO of chromatographic column is connected with the import of hot-water cylinder, and the outlet of hot-water cylinder is connected with the import of heat exchanger by heat-exchanger pump.
The beneficial effect of the full-automatic chromatography unit of the utility model is: the chromatography unit that adopts said structure, be equipped with technological parameter on-line detector device and computer control software, by computer control pump, valve event, realize that easily liquid conveying control and pipeline switch, important chromatography technological parameter flow, pressure, temperature, pH, electrical conductivity and ultraviolet spectra are realized on-line monitoring, make the full-automatic chromatography unit of the utility model be easy to the amplification of chromatography technology, really solve the problem of suitability for industrialized production.The full-automatic chromatography unit of the utility model has operating condition gentleness (normal temperature, be generally normal pressure), efficient (mixture is once by obtaining a plurality of pure components simultaneously), preparation amount is big, cost is low, easily realize advantage such as industrialization amplification.
The utility model will be further described below in conjunction with the drawings and specific embodiments.
Description of drawings
Accompanying drawing is the general structure schematic diagram of a kind of embodiment of the full-automatic chromatography unit of the utility model.
Reference numeral in the accompanying drawing is: 1, computer controlling center; 2, material-compound tank; 3, first solvent tank; 4, second solvent tank; 5, diaphragm metering pump; 5a, first diaphragm metering pump; 5b, second diaphragm metering pump; 6, buffer; 6a, first buffer; 6b, second buffer; 7, pipe-line mixer; 8, Pneumatic butterfly valve; 9, chromatographic column; 9a, first chromatographic column; 9b, second chromatographic column; 9c, the 3rd chromatographic column; 10, hand-operated valve; 11, heat exchanger; 12, heat-exchanger pump; 13, the first regenerated liquid storage tank; 14, the second regenerated liquid storage tank; 15, the first chromatography liquid storage tank; 16, the second chromatography liquid storage tank; 17, hot-water cylinder; 18, flow transmitter.
Pneumatic butterfly valves all in the accompanying drawing are numbered 8; All hand-operated valves are numbered 10; All flow transmitters are numbered 18.
The specific embodiment
As shown in drawings, a kind of embodiment of the full-automatic chromatography unit of the utility model, comprise computer controlling center 1, material-compound tank 2, first solvent tank 3, second solvent tank 4, the first diaphragm metering pump 5a, the second diaphragm metering pump 5b, the first buffer 6a, the second buffer 6b, pipe-line mixer 7, Pneumatic butterfly valve 8, flow transmitter 18, the first chromatographic column 9a, the second chromatographic column 9b, the 3rd chromatographic column 9c, hand-operated valve 10, the chromatographic solution storage tank, the regenerated liquid storage tank, hot-water cylinder 17, heat-exchanger pump 12, heat exchanger 11, material-compound tank 2 and first solvent tank 3 are connected with the import of the first diaphragm metering pump 5a by Pneumatic butterfly valve 8 separately respectively, second solvent tank 4 is connected with the import of the second diaphragm metering pump 5b by Pneumatic butterfly valve 8, the outlet of the outlet of the first diaphragm metering pump 5a and the second diaphragm metering pump 5b is connected with the import of pipe-line mixer 7 respectively, the outlet of pipe-line mixer 7 by separately Pneumatic butterfly valve 8 and flow transmitter 18 respectively with the import of the first chromatographic column 9a, the import of the second chromatographic column 9b, the import of the 3rd chromatographic column 9c connects, the outlet of the first chromatographic column 9a, the outlet of the second chromatographic column 9b, after the hand-operated valve 10 of the outlet of the 3rd chromatographic column 9c by separately is merged into a pipeline, through Pneumatic butterfly valve 8, flow transmitter 18 is connected with the import of chromatographic solution storage tank and the import of regenerated liquid storage tank respectively, the outlet of heat exchanger 11 is connected with the chuck import of the 3rd chromatographic column 9c, the JO of the 3rd chromatographic column 9c is connected with the chuck import of the second chromatographic column 9b, the JO of the second chromatographic column 9b is connected with the chuck import of the first chromatographic column 9a, the JO of first chromatographic column is connected with the import of hot-water cylinder 17, and the outlet of hot-water cylinder 17 is connected with the import of heat exchanger 11 by heat-exchanger pump 12.For the ease of processing one by one, the import of the first chromatographic column 9a is connected by the outlet of Pneumatic butterfly valve with the second chromatographic column 9b, and the import of the second chromatographic column 9b is connected by the outlet of Pneumatic butterfly valve with the 3rd chromatographic column 9c.For the ease of collecting the different component chromatographic solution, described chromatographic solution storage tank comprises the first chromatography liquid storage tank 15, the second chromatography liquid storage tank 16, the first chromatography liquid storage tank 15, the second chromatography liquid storage tank 16 are parallel-connection structure, and promptly the first chromatography liquid storage tank 15, the second chromatography liquid storage tank 16 are connected with the export pipeline of chromatographic column 9 respectively by hand-operated valve 10 separately.For the ease of collecting remaining regenerated liquid, described chromatographic solution storage tank comprises the first regenerated liquid storage tank 13, the second regenerated liquid storage tank 14, ground floor regenerated liquid storage tank 13, the second regenerated liquid storage tank 14 are parallel-connection structure, and promptly ground floor regenerated liquid storage tank 13, the second regenerated liquid storage tank 14 are connected with the export pipeline of chromatographic column 9 respectively by hand-operated valve 10 separately.
The operation principle of the full-automatic chromatography unit of the utility model is: a, connection power supply, and computer controlling center 1 starts, and device systems detects; B, material-compound tank 2 chargings, first solvent tank 3, second solvent tank 4 inject solvent respectively, and heat exchanger 11 temperature are set in hot-water cylinder 17 heating, and the chuck that starts 12 couples first chromatographic column 9a of heat-exchanger pump, the second chromatographic column 9b, the 3rd chromatographic column 9c heats; C, computer controlling center 1 detect feed concentration, setting solvent (phase flows) index and flow, the index of the sorbing material (fixedly phase) in mensuration the layer first chromatographic column 9a, second a chromatographic column 9b, the 3rd chromatographic column 9c; D, start the defeated feed liquids of material-compound tank 2 respectively; The first diaphragm metering pump 5a make feed liquid pass through the first buffer 6a, pipe-line mixer 7, Pneumatic butterfly valve 8 (corresponding Pneumatic butterfly valve), flow transmitter 18 (corresponding flow transmitter) enter chromatographic column 9 (single-column enter or multicolumn enter simultaneously all can) and be adsorbed on fixing in the chromatographic column 9 and go up mutually; E, computer controlling center 1 detect feed liquid chromatographic column 9 in fix mutually on adsorb and finish, start first solvent tank 3 respectively, second solvent tank, 4 defeated solvents, the first diaphragm metering pump 5a and second diaphragm metering pump 5b work make the solvent of two kinds of variable concentrations pass through Pneumatic butterfly valve 8 (corresponding Pneumatic butterfly valve) by the first buffer 6a and the second buffer 6b after pipe-line mixer 7 mixes respectively, flow transmitter 18 (corresponding flow transmitter) enter chromatographic column 9 (single-column enter or multicolumn enter simultaneously all can) and the fixing feed liquids that go up mutually that are adsorbed in the chromatographic column 9 are carried out recycling elution; Hand-operated valve 10 (counterpart) inspection by sampling of f, unlatching chromatographic column 9 belows starts Pneumatic butterfly valve 8 (counterpart) and flow transmitter 18 (counterpart) with in qualified the chromatography material input ground floor analysis of material storage tank 15 or second layer analysis of material storage tank 16; The Pneumatic butterfly valve 8 (counterpart) and the flow transmitter 8 (counterpart) of g, unlatching chromatographic column 9 belows are imported the regenerated liquid of remnants in the first regenerated liquid storage tank 13 or the second regenerated liquid storage tank 14, can carry out secondary as required or repeat wash-out three times, open Pneumatic butterfly valve 8 (counterpart) blowdown of chromatographic column 9 belows; H, unit can carry out disposable material feeding processing to all chromatographic columns 9 simultaneously, also can the chromatography material be undertaken forward by circuit shown in the drawings or reverse processing one by one by different requirements, and method is identical with the step of above-mentioned a-g.
The foregoing description has been done detailed description to the utility model; but not to restriction of the present utility model; the utility model can also change to some extent; as long as the utility model possesses following structure: with reference to the accompanying drawings; comprise material-compound tank 2; solvent tank 3; diaphragm metering pump 5; buffer 6; Pneumatic butterfly valve 8; flow transmitter 18; chromatographic column 9; hand-operated valve 10; the chromatographic solution storage tank; the regenerated liquid storage tank; hot-water cylinder 17; heat-exchanger pump 12; heat exchanger 11; material-compound tank 2 and solvent tank 3 are connected with the import of diaphragm metering pump 5 by Pneumatic butterfly valve 8 separately respectively; buffer 6 is passed through in the outlet of diaphragm metering pump 5 successively; Pneumatic butterfly valve 8; flow transmitter 18 is connected with the import of chromatographic column 9; hand-operated valve 10 is passed through in the outlet of chromatographic column 9 successively; Pneumatic butterfly valve 8; flow transmitter 18 is connected with the import of chromatographic solution storage tank and the import of regenerated liquid storage tank respectively; the outlet of heat exchanger 11 is connected with the chuck import of chromatographic column 9; the JO of chromatographic column 9 is connected with the import of hot-water cylinder 17; the outlet of hot-water cylinder 17 is connected with the import of heat exchanger 11 by heat-exchanger pump 12; can solve technical problem of the present utility model, therefore protection domain of the present utility model should be determined by claim.
Claims (6)
1, a kind of full-automatic chromatography unit, it is characterized in that: comprise material-compound tank (2), solvent tank (3), diaphragm metering pump (5), buffer (6), Pneumatic butterfly valve (8), flow transmitter (18), chromatographic column (9), hand-operated valve (10), the chromatographic solution storage tank, the regenerated liquid storage tank, hot-water cylinder (17), heat-exchanger pump (12), heat exchanger (11), material-compound tank (2) and solvent tank (3) are connected with the import of diaphragm metering pump (5) by Pneumatic butterfly valve (8) separately respectively, buffer (6) is passed through in the outlet of diaphragm metering pump (5) successively, Pneumatic butterfly valve (8), flow transmitter (18) is connected with the import of chromatographic column (9), hand-operated valve (10) is passed through in the outlet of chromatographic column (9) successively, Pneumatic butterfly valve (8), flow transmitter (18) is connected with the import of chromatographic solution storage tank and the import of regenerated liquid storage tank respectively, the outlet of heat exchanger (11) is connected with the chuck import of chromatographic column (9), the JO of chromatographic column (9) is connected with the import of hot-water cylinder (17), and the outlet of hot-water cylinder (17) is connected with the import of heat exchanger (11) by heat-exchanger pump (12).
2, full-automatic chromatography unit according to claim 1, it is characterized in that: described solvent tank (3) comprises first solvent tank (3), second solvent tank (4), described diaphragm metering pump (5) comprises first diaphragm metering pump (5a), second diaphragm metering pump (5b), described buffer (6) comprises first buffer (6a), second buffer (6b), also comprise pipe-line mixer (7), described chromatographic column (9) comprises first chromatographic column (9a), second chromatographic column (9b), the 3rd chromatographic column (9c), material-compound tank (2) and first solvent tank (3) are connected with the import of first diaphragm metering pump (5a) by Pneumatic butterfly valve (8) separately respectively, second solvent tank (4) is connected with the import of second diaphragm metering pump (5b) by Pneumatic butterfly valve (8), the outlet of the outlet of first diaphragm metering pump (5a) and second diaphragm metering pump (5b) is connected with the import of pipe-line mixer (7) respectively, the outlet of pipe-line mixer (7) by separately Pneumatic butterfly valve (8) and flow transmitter (18) respectively with the import of first chromatographic column (9a), the import of second chromatographic column (9b), the import of the 3rd chromatographic column (9c) connects, the outlet of first chromatographic column (9a), the outlet of second chromatographic column (9b), after the hand-operated valve (10) of the outlet of the 3rd chromatographic column (9c) by separately is merged into a pipeline, through Pneumatic butterfly valve (8), flow transmitter (18) is connected with the import of chromatographic solution storage tank and the import of regenerated liquid storage tank respectively, the outlet of heat exchanger (11) is connected with the chuck import of the 3rd chromatographic column (9c), the JO of the 3rd chromatographic column (9c) is connected with the chuck import of second chromatographic column (9b), the JO of second chromatographic column (9b) is connected with the chuck import of first chromatographic column (9a), the JO of first chromatographic column (9a) is connected with the import of hot-water cylinder (17), and the outlet of hot-water cylinder (17) is connected with the import of heat exchanger (11) by heat-exchanger pump (12).
3, full-automatic chromatography unit according to claim 2, it is characterized in that: the import of first chromatographic column (9a) is connected with the outlet of second chromatographic column (9b) by Pneumatic butterfly valve (8), and the import of second chromatographic column (9b) is connected with the outlet of the 3rd chromatographic column (9c) by Pneumatic butterfly valve (8).
4, according to claim 2 or 3 described full-automatic chromatography units, it is characterized in that: described chromatographic solution storage tank comprises the first chromatography liquid storage tank (15), the second chromatography liquid storage tank (16), and the first chromatography liquid storage tank (15), the second chromatography liquid storage tank (16) are parallel-connection structure.
5, according to claim 2 or 3 described full-automatic chromatography units, it is characterized in that: described chromatographic solution storage tank comprises the first regenerated liquid storage tank (13), the second regenerated liquid storage tank (14), and ground floor regenerated liquid storage tank (13), the second regenerated liquid storage tank (14) are parallel-connection structure.
6, full-automatic chromatography unit according to claim 4, it is characterized in that: described chromatographic solution storage tank comprises the first regenerated liquid storage tank (13), the second regenerated liquid storage tank (14), and ground floor regenerated liquid storage tank (13), the second regenerated liquid storage tank (14) are parallel-connection structure.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2008201621447U CN201249052Y (en) | 2008-08-02 | 2008-08-02 | Full-automatic chromatographic separator set |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2008201621447U CN201249052Y (en) | 2008-08-02 | 2008-08-02 | Full-automatic chromatographic separator set |
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| Publication Number | Publication Date |
|---|---|
| CN201249052Y true CN201249052Y (en) | 2009-06-03 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNU2008201621447U Expired - Fee Related CN201249052Y (en) | 2008-08-02 | 2008-08-02 | Full-automatic chromatographic separator set |
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| Country | Link |
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| CN (1) | CN201249052Y (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105194905A (en) * | 2015-10-22 | 2015-12-30 | 宁波荣安生物药业有限公司 | Chromatography system |
| CN109395427A (en) * | 2019-01-03 | 2019-03-01 | 湖州欧利生物科技有限公司 | A kind of environment-friendly type glabridin extraction element and its technique |
-
2008
- 2008-08-02 CN CNU2008201621447U patent/CN201249052Y/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105194905A (en) * | 2015-10-22 | 2015-12-30 | 宁波荣安生物药业有限公司 | Chromatography system |
| CN105194905B (en) * | 2015-10-22 | 2017-04-12 | 宁波荣安生物药业有限公司 | Chromatography system |
| CN109395427A (en) * | 2019-01-03 | 2019-03-01 | 湖州欧利生物科技有限公司 | A kind of environment-friendly type glabridin extraction element and its technique |
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| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of utility model: Full-automatic chromatographic separator set Effective date of registration: 20100712 Granted publication date: 20090603 Pledgee: Bank of Wenzhou Limited by Share Ltd Ouhai branch Pledgor: Wenzhou Jinbang Light Industry Machinery Co., Ltd. Registration number: 2010990000808 |
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Date of cancellation: 20110830 Granted publication date: 20090603 Pledgee: Bank of Wenzhou Limited by Share Ltd Ouhai branch Pledgor: Wenzhou Jinbang Light Industry Machinery Co., Ltd. Registration number: 2010990000808 |
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Denomination of utility model: Full-automatic chromatographic separator set Effective date of registration: 20110915 Granted publication date: 20090603 Pledgee: Bank of Wenzhou Limited by Share Ltd Ouhai branch Pledgor: Wenzhou Jinbang Light Industry Machinery Co., Ltd. Registration number: 2011990000350 |
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Date of cancellation: 20120810 Granted publication date: 20090603 Pledgee: Bank of Wenzhou Limited by Share Ltd Ouhai branch Pledgor: Wenzhou Jinbang Light Industry Machinery Co., Ltd. Registration number: 2011990000350 |
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| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of utility model: Full-automatic chromatographic separator set Effective date of registration: 20120810 Granted publication date: 20090603 Pledgee: Bank of Wenzhou Limited by Share Ltd Ouhai branch Pledgor: Wenzhou Jinbang Light Industry Machinery Co., Ltd. Registration number: 2012990000441 |
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Date of cancellation: 20131128 Granted publication date: 20090603 Pledgee: Bank of Wenzhou Limited by Share Ltd Ouhai branch Pledgor: Wenzhou Jinbang Light Industry Machinery Co., Ltd. Registration number: 2012990000441 |
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| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of utility model: Full-automatic chromatographic separator set Effective date of registration: 20131128 Granted publication date: 20090603 Pledgee: Bank of Wenzhou Limited by Share Ltd Ouhai branch Pledgor: Wenzhou Jinbang Light Industry Machinery Co., Ltd. Registration number: 2013990000909 |
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Date of cancellation: 20120810 Granted publication date: 20090603 Pledgee: Bank of Wenzhou Limited by Share Ltd Ouhai branch Pledgor: Wenzhou Jinbang Light Industry Machinery Co., Ltd. Registration number: 2011990000350 |
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