CN201668979U - Sequential type simulated moving bed chromatography purification device - Google Patents
Sequential type simulated moving bed chromatography purification device Download PDFInfo
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- CN201668979U CN201668979U CN2009202748990U CN200920274899U CN201668979U CN 201668979 U CN201668979 U CN 201668979U CN 2009202748990 U CN2009202748990 U CN 2009202748990U CN 200920274899 U CN200920274899 U CN 200920274899U CN 201668979 U CN201668979 U CN 201668979U
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Abstract
The utility model relates to a sequential type simulated moving bed chromatography purification device. At present, all simulated moving beds used at home and abroad have the problems of low purification purity and low production efficiency caused by easy material accumulation and non-constant chromatographic column temperature. The utility model belongs to a set of external full-sealed security system, wherein the system is surrounded by a box body and is controlled by an external self control operation panel, the device consists of a material inlet tank, a material inlet pump, a water inlet tank, a water inlet pump, a raffinate tank, an extracting solution tank, chromatographic columns, an automatic valve, a pressure stabilizing valve and the like, wherein a fine filter is respectively arranged behind the material inlet pump and the water inlet pump for preventing the flowing blockage of pipelines, a circulation pump is arranged between every two chromatographic columns, materials can smoothly pass through fixed phases in the chromatographic columns through being pushed by the pump, and the accumulation can be avoided. The chromatographic columns are arranged in the heat insulation circulation water tank, and maintain the constant temperature of the device, and the purification precision is improved. The utility model has simple structure, convenient maintenance and precise process procedures, and can realize high-precision separation.
Description
Technical field
The utility model relates to the process-scale chromatography purifying plant, particularly relates to a kind of sequential simulated moving bed chromatogram purifying plant.
Background technology
Chromatogram is as a kind of separation method and technology, and its range of application comprises lab analysis and large-scale two aspects of industrial separation.In theory, all chromatographic techniques can be applied to industrial separation.The key of problem is to solve the problem that separative efficiency sharply descends with the amplification of chromatographic column.Also will solve the efficiency of operating process simultaneously, separative efficiency and operating efficiency are the main causes that hinders chromatographic technique to use in industrial separation.
Sequential simulated moving bed is a kind of novel modernized isolation technics that grows up on the moving bed basis.It mainly changes the position of liquid gateway by the turnover feed liquid of regular switching chromatograph post and the valve of parsing agent, thereby realizes relatively moving of solid-liquid two-phase.This process is the good filling performance of existing fixed bed, but has the characteristics of moving bed continued operation again simultaneously, has overcome moving bed filling inconvenience and characteristics easy to wear simultaneously again, has therefore obtained using widely at chemical industry and pharmaceutical industry.But because simulation moving-bed separating mechanism more complicated, its separation process also is not quite similar to different products.
Summary of the invention
The purpose of this utility model is to overcome deficiency of the prior art, and a kind of sequential simulated moving bed chromatogram purifying plant that can realize high efficiency and made with high precision is provided.
For achieving the above object, technical scheme of the present invention is:
A kind of sequential simulated moving bed chromatogram purifying plant, comprise chromatographic column, pipeline, valve, circulating pump, its special character is: also comprise accurate filter, head tank, feed pump, water inlet jar, intake pump, extraction flow container, raffinate jar, described head tank is connected by pipeline with feed pump, and feed pump is connected with feed pipe through accurate filter; The water inlet jar is connected by pipeline with intake pump, and the water inlet jar is connected with water inlet pipe through accurate filter; Connect the extraction flow container behind the extract collecting pipe, connect the raffinate jar behind the raffinate collecting pipe.
Above-mentioned chromatographic column, pipeline, valve, circulating pump, accurate filter, head tank, feed pump, water inlet jar, intake pump, extraction flow container, raffinate jar are arranged in the closed environment, control panel is in box outer surface, and whole system is a transportable single unit system.
Above-mentioned feed pump, intake pump are provided with accurate filter before all.
Above-mentioned chromatographic column is placed in the circulation attemperater.
Between above-mentioned per two chromatographic columns circulating pump is set.
Compared with prior art, overcome the defective of traditional simulation moving-bed solid accumulation in the technological design of the utility model package unit, it has settled the recycle feed pump in the middle of per two root chromatogram columns, by the promotion of pump, material can be avoided piling up smoothly by the fixedly phase in the chromatographic column; Secondly, when the purification material, have two chromatographic columns and be in idle state, can avoid the circulation of material not smooth by the cyclic design that adds pump this moment.Batch can by self circulation of material pump, can be avoided the circulation clogging of pipeline when charging not, these designs have fundamentally improved the traditional analog moving bed and have not been suitable for industrial drawback, and it can be applied in the middle of the large-scale industrial production.
Description of drawings
Fig. 1 is simulation moving-bed schematic diagram;
Fig. 2 is this apparatus structure schematic diagram.
Description of reference numerals is as follows:
1-chromatographic column, 2-circulating pump, 3-accurate filter, 4-head tank, 5-feed pump, 6-are intake jar, the 7-intake pump, and 8-extracts flow container, 9-raffinate jar.
The specific embodiment
Below in conjunction with the drawings and specific embodiments the utility model is elaborated.
Simulation moving-bed schematic diagram as shown in Figure 1.8 root chromatogram columns 1 connect into yi word pattern by pipeline, valve, pump, and are similar to true moving bed, also are divided into 4 zones.Each regional function is as follows: the I district is used for wash-out and moves component slowly, the II district makes moving component absorption repeatedly slowly, desorb and concentrating of being adsorbed, the III district is used for absorption and moves component faster, the IV district is used to adsorb the unnecessary mobile component faster that does not propose, component enters the I district and pollutes to carry and move the extract of component slowly in order to avoid move faster, and make eluent enter the I district, reach recycling purpose with fresh eluent.Different is the separable programming that this device method of purification is different from the traditional analog moving bed, the material but circulation after the employing charging, wash water, wash-out (water inlet and charging) cell process program is purified, after each unit program finished, circulation restarted new unit program from next post.All programs all turn round under the robot control system(RCS) control of device.To be that chromatographic peak wants narrow and distance is wide just can reach good effect to the condition that common chromatographic isolation will obtain pure product, and this device is only required in before and after the peak non-overlapping portions and just can purifies, avoid the waste of long separation and resource, saved cost.
This apparatus structure schematic diagram is seen Fig. 2.Comprise head tank 4, water inlet jar 6 extracts flow container 8,1,2 accurate filter 3 of raffinate jar 9,8 root chromatogram columns, and feed pump 5,7,4 circulating pumps 2 of intake pump, automatic valve is some, pressure maintaining valve, flowmeter, pressure transmitter, thermometer.Head tank 4 is connected respectively to the top of 8 root chromatogram columns 1 by pipeline, and automatic valve is set on the pipeline, and head tank 4 advances in people's chromatographic column 1 by feed pump 5 and accurate filter 3.Water inlet jar 6 is connected respectively to the top of 8 root chromatogram columns 1 by intake pump 7 and accurate filter 3, and Self controlling valve is set on the pipeline.8 root chromatogram columns 1 join end to end into a closed structure, from left to right are followed successively by No. 1 chromatographic column, No. 2 chromatographic columns, No. 3 chromatographic columns, No. 4 chromatographic columns, No. 5 chromatographic columns, No. 6 chromatographic columns, No. 7 chromatographic columns, No. 8 chromatographic columns.In the middle of No. 1 chromatographic column and No. 2 chromatographic columns, in the middle of No. 3 chromatographic columns and No. 4 chromatographic columns, between No. 5 and No. 6, all settle circulating pump 2 between No. 7 and No. 8 chromatographic columns.Connect raffinate outlet line and extracting liquid outlet pipeline at every root chromatogram column tail end, cause respectively in raffinate jar 9 and the extraction flow container 10.The port of export of feed pump 5 and intake pump 7 links to each other respectively with the top of head tank 4 with water inlet jar 6.8 root chromatogram columns 1 all place cyclic water tank, and the interior material of post can be moved under steady temperature, have guaranteed the effect of chromatographic isolation like this.Operating circulating water is adjusted temperature by the mould temperature controller.
Claims (5)
1. sequential simulated moving bed chromatogram purifying plant, comprise chromatographic column (1), pipeline, valve, circulating pump (2), it is characterized in that: also comprise accurate filter (3), head tank (4), feed pump (5), water inlet jar (6), intake pump (7), extract flow container (8), raffinate jar (9), described head tank (4) is connected by pipeline with feed pump (5), and feed pump (5) is connected with feed pipe through accurate filter (3); Water inlet jar (6) is connected by pipeline with intake pump (7), and water inlet jar (6) is connected with water inlet pipe through accurate filter (3); Connect behind the extract collecting pipe and extract flow container (8), connect raffinate jar (9) behind the raffinate collecting pipe.
2. a kind of sequential simulated moving bed chromatogram purifying plant according to claim 1, it is characterized in that: described chromatographic column (1), pipeline, valve, circulating pump (2), accurate filter (3), head tank (4), feed pump (5), water inlet jar (6), intake pump (7), extraction flow container (8), raffinate jar (9) and automatic operation platform all are arranged in the closed environment, control panel is in box outer surface, and whole system is a transportable single unit system.
3. a kind of sequential simulated moving bed chromatogram purifying plant according to claim 1 and 2 is characterized in that: described feed pump (5), the preceding accurate filter (3) that is provided with of intake pump (7).
4. a kind of sequential simulated moving bed chromatogram purifying plant according to claim 1 and 2, it is characterized in that: described chromatographic column (1) is placed in the circulation attemperater.
5. a kind of sequential simulated moving bed chromatogram purifying plant according to claim 1 and 2 is characterized in that: circulating pump (2) is set between described per two chromatographic columns (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009202748990U CN201668979U (en) | 2009-12-31 | 2009-12-31 | Sequential type simulated moving bed chromatography purification device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009202748990U CN201668979U (en) | 2009-12-31 | 2009-12-31 | Sequential type simulated moving bed chromatography purification device |
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| Publication Number | Publication Date |
|---|---|
| CN201668979U true CN201668979U (en) | 2010-12-15 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2009202748990U Expired - Lifetime CN201668979U (en) | 2009-12-31 | 2009-12-31 | Sequential type simulated moving bed chromatography purification device |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108410719A (en) * | 2018-02-26 | 2018-08-17 | 西王药业有限公司 | A kind of new process of purification saccharified liquid |
| CN113893578A (en) * | 2021-09-08 | 2022-01-07 | 四川雅华生物有限公司 | Separation and purification system and process method of hydrolysate |
| CN114272645A (en) * | 2021-10-08 | 2022-04-05 | 欧尚元(天津)有限公司 | Chromatographic separation system |
-
2009
- 2009-12-31 CN CN2009202748990U patent/CN201668979U/en not_active Expired - Lifetime
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108410719A (en) * | 2018-02-26 | 2018-08-17 | 西王药业有限公司 | A kind of new process of purification saccharified liquid |
| CN113893578A (en) * | 2021-09-08 | 2022-01-07 | 四川雅华生物有限公司 | Separation and purification system and process method of hydrolysate |
| CN114272645A (en) * | 2021-10-08 | 2022-04-05 | 欧尚元(天津)有限公司 | Chromatographic separation system |
| CN114272645B (en) * | 2021-10-08 | 2023-06-02 | 欧尚元智能装备有限公司 | Chromatographic separation system |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20101215 |