CN100427174C - Integrated process and apparatus for extracting and separating effective Chinese medicine components - Google Patents
Integrated process and apparatus for extracting and separating effective Chinese medicine components Download PDFInfo
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- CN100427174C CN100427174C CNB2006101144871A CN200610114487A CN100427174C CN 100427174 C CN100427174 C CN 100427174C CN B2006101144871 A CNB2006101144871 A CN B2006101144871A CN 200610114487 A CN200610114487 A CN 200610114487A CN 100427174 C CN100427174 C CN 100427174C
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Abstract
The present invention relates to integrated process and apparatus for extracting and separating effective Chinese medicine components. The process includes the following steps: 1. extracting Chinese medicine material powder in extraction apparatus with extracting solution; 2. conveying the extracted liquid upwards to the column of the expanding bed and returning the adsorbed liquid after heat exchange to the extractor for dynamic extraction; 3. stopping extraction after reaching extracted target component content in the extracted liquid and conveying the flushing liquid upwards to the column to flush the solid grain and impurity to the automatic collector until the flushing liquid become clear; 4. conveying eluent downwards to the column and collecting the eluted liquid to the automatic collector; and 5. conveying one other kind of eluent downwards to the column after elution to regenerate the column and collecting the eluted liquid to the automatic collector.
Description
Technical field
The present invention relates to a kind of method and device that extracts separating traditional Chinese medicine, particularly about a kind of method and device of integrated extraction separating traditional Chinese medicine.
Background technology
Chinese medicine active principle or composition and active component are the material bases of the disease of China's traditional Chinese medicine treatment for thousands of years.Medicinal herb components is very complicated, and the material that plays the curative effect effect should be the chemical composition of broad sense, comprises inorganic matter, little molecular organic compound (as volatile oil, alkaloid, flavones, saponin(e etc.).Extract separating effective ingredient and active component and help reducing former drug toxicity, improve curative effect of medication, help improving form of Chinese drug, the control quality of production, help enlarging Chinese herbal medicine resource, help carrying out the chemical synthesis or the structure of modification of Chinese medicine,, promote that study of tcm new drug and modernized aspect are all significant exploring the principle that Chinese herbal medicine is cured the disease.In the herbal pharmaceutical industry operation of most critical be to the extraction of its active ingredient with separate, traditional extraction separation method, ubiquity that effective component extraction rate is low, energy consumption is high, operation is many and shortcoming such as the production cycle is long, has directly restricted the development of herbal pharmaceutical industry.
In the herbal pharmaceutical engineering, the expense of separation and purifying often accounts for very big proportion.Less when dregs of a decoction size, with traditional filtration or centrifugal method, be difficult to remove, and expense is higher.Because the herbal extract volume is big, the turbidity height, it is difficult, time-consuming many to handle, so first step Separation of Solid and Liquid often becomes the restriction step of whole Chinese medicine separation and purification.Usually separation and purifying are made up of a series of unit operations, and wherein the first step often for the Separation of Solid and Liquid operation, is removed the solid particle in the Chinese medicine extract, obtains supernatant liquid, then concentrates or preliminary purification with additive method.In recent years, along with the fast development of modern project technology, some modern high technologies constantly are applied to traditional Chinese medicine research, exploitation and production, have promoted the development of Chinese medicine industry greatly, make the herbal pharmaceutical technical merit rise to a new height.Aspect middle pharmaceutically active ingredient separation, proposed such as new methods such as membrane separation technique, chromatographic techniques.But the former exists the pollution problem of film that flux is descended, and the latter's a big shortcoming is to handle the feed liquid that contains solid particle.In chromatographic technique, the fixed bed mode is mainly taked in general active ingredient separation, and promptly feed liquid is flowed through from the VELOCITY DISTRIBUTION device on post top the post of chromatography media is housed, and flows out from the bottom of post, and liquid flows in dielectric layer and is laminar flow basically, and back-mixing is little, and post is imitated high.But when containing solid particle in the feed liquid, because the space between medium is very little, particle is trapped between medium, results in blockage, and bed pressure drop increases, and absorption can't be carried out.So must carry out Separation of Solid and Liquid to material liquid before the employing chromatography method, steps such as promptly necessary process is centrifugal, filtration, this just makes separation process elongated, and separative efficiency reduces, and the target component loss is more.Though can directly adsorb the feed liquid that contains particle, there is the problem of back-mixing if take the fluid bed mode in Solid-Liquid Separation.Be in the monodispersed fluid bed at particle diameter, experimental results show that solid particle almost can move to any position of bed, illustrate to have serious back-mixing.The existence of air-teturning mixed phenomenon makes the theoretical cam curve of bed reduce (theoretical cam curve is to describe the index that post is imitated), causes separating power to reduce.
Integrated technology promptly effectively makes up existing two or more unit operations, forms a kind of more effective unit operations, improves product yield to reach, shortens purification step, reduces the purpose of purifying expense and cost of investment.Expanded Bed Adsorption (Expanded bed adsorption) is the novel separating and purifying technology that last century, the nineties grew up, be to integrate clarification, concentrate and the novel integrated operating process of preliminary purification, can reduce unit operations steps such as centrifugal or filtration, the save operation cycle, improve the yield of target product, reduce the cost of separation and purification, be called as first the new unit operations that occurs in recent decades.Along with the appearance of commercialization adsorbent and device, much more more and more expansion bed causes people's interest and concern.
As a new unit operations, the expansion bed technological synthesis advantage of fluid bed and packed bed, overcome some defectives of fluid bed and packed bed self simultaneously.The difference of the maximum of expansion bed and fluid bed is: in the expansion bed fluid with the bed of flowing through near the mode of laminar flow, thereby obtain good separating effect.The difference of expansion bed and fixed bed is: expansion bed has higher voidage, and bed pressure drop is little, can allow passing through of solid particle in the feed liquid, and the utilization rate height of adsorbent, the separative efficiency height.Expanded Bed Adsorption is separated a model as integrated isolation technics, and a large amount of reports have been arranged in the biological product separation and purification, but yet there are no application in middle pharmaceutically active ingredient separates.
Summary of the invention
At the problems referred to above, the purpose of this invention is to provide a kind ofly will extract, the function of centrifugal, filtration and purifying is integrated in the operating unit, by the operation of this operating unit, just can directly from Chinese medicine, isolate the method and the device of the integrated extraction separating effective Chinese medicine components of active ingredient.
For achieving the above object, the present invention takes following technical scheme: a kind of method of integrated extraction separating effective Chinese medicine components, and it may further comprise the steps: (1) places extraction element after Chinese medicine is pulverized, and adds extractant, extracts; (2) when extracting, open infusion pump, extract from bottom to top is delivered in the expansion bed cylinder, adsorb surplus liquid after the preheating heat-changing tube preheating, flow back into and continue to participate in traditional Chinese medicine extraction in the extraction element, formation is adsorbed on the interior resin of expansion bed body active ingredient to the Dynamic Extraction of extract; (3) treating that the online detection and control device detects in the extract stops to extract after target component content is lower than setting value, by infusion pump flushing liquor from bottom to top is delivered in the cylinder of expansion bed from expansion bed bottom, solid particle and impurity is gone out sent into automatic collector; (4) treat after the clarification of Xian's liquid, eluant, eluent from top to bottom to be delivered to from the expansion bed top in the cylinder of expansion bed, collect eluent simultaneously in automatic collector by infusion pump; (5) treat that the online detection and control device detects that target component content stops wash-out after being lower than setting value in the eluent, from top to bottom be delivered to another eluant, eluent in the cylinder of expansion bed from the expansion bed top by infusion pump, finish the regenerative process of post, collect eluent simultaneously in automatic collector.
Described extraction element for the band heating jacket extractor, ultrasonic extraction device, Microwave Extraction device, percolating extractor, bionic extraction device and half bionic extraction device in a kind of.
Described target component refers to the described Effective Components of Chinese Herb of preextraction or separation.
A kind of device of integrated extraction separating effective Chinese medicine components, it is characterized in that, it comprises: an extraction element, one heat exchanger, be provided with preheating heat-changing tube and cooling heat transferring pipe in it, described extraction element connects the inlet of described preheating heat-changing tube and cooling heat transferring pipe respectively by pipeline, the liquid outlet of described cooling heat transferring pipe connects a triple valve by pipeline; Described triple valve connects the inlet of a cross valve and an infusion pump respectively by pipeline; Other three mouths of this cross valve connect a washing device and two NaOH solution tank NaOHs by pipeline respectively; The liquid outlet of described preheating heat-changing tube connects a triple valve by pipeline, described triple valve connects the upper port and a cross valve of an expansion bed respectively by pipeline, other three mouths of this cross valve connect the liquid outlet of described infusion pump, the lower port and an automatic collector of expansion bed respectively, the online detection and control device in parallel of the cross valve two ends on pipeline between described expansion bed lower port and the described automatic collector inlet.
A kind of in extractor, ultrasonic extraction device, Microwave Extraction device, percolating extractor, bionic extraction device and the half bionic extraction device of described extraction element for the band heating jacket.
The present invention is owing to take above technical scheme, it has the following advantages: 1, the method and the device of active ingredient in the integrated extraction separating traditional Chinese medicine of the present invention, save tradition extract centrifugal in the separation process, step such as filter, concentrate, with extract, the function of centrifugal, filtration and purifying is integrated in the operating unit and carries out, directly separating effective ingredient from crude extract has efficient height, step simplification, separates the characteristics that feed liquid is effective, cost is low that contain solid particle.2, the present invention is integrated with extraction element and expansion bed, when Chinese medicine extract fashionable from the expansion bed bottom pump, the mutual space of the inner adsorbent of expansion bed increases, and formed the gradient distribution, allow the solid granule in the extract to flow out by the bed space, and active ingredient is attracted on the interior adsorbent of expansion bed, thereby has realized the initial gross separation of extract.Whole process adopts Dynamic Extraction to strengthen mass transport process, and therefore under the prerequisite that guarantees extraction efficiency and effective component yield, the operation cycle significantly shortens than traditional extracting mode.3, the inventive method and device adopt channelization, totally-enclosed production process, have reduced the time of contact with air, can avoid the pollution of material.4, owing to the integrated extraction of the inventive method separates the time spent weak point, can reduce some to thermally sensitive composition and hot time of contact, can prevent the problem of the yield reduction that its degraded brings.
Description of drawings
Fig. 1 is apparatus of the present invention structural representations
Fig. 2 is the schematic diagram of the inventive method step 2 flow direction
Fig. 3 is the schematic diagram of the inventive method step 3 flow direction
Fig. 4 is the schematic diagram of the inventive method step 4 flow direction
Fig. 5 is the schematic diagram of the inventive method step 5 flow direction
The specific embodiment
Below in conjunction with drawings and Examples invention is described in detail.
Embodiment 1:
As shown in Figure 1, the device of the integrated extraction separating effective Chinese medicine components of the present invention comprises: the extractor 1 of a band heating jacket, one heat exchanger, be provided with preheating heat-changing tube 2 and cooling heat transferring pipe 3 in the heat exchanger, extractor 1 connects the inlet of preheating heat-changing tube 2 and cooling heat transferring pipe 3 respectively by pipeline, the liquid outlet of cooling heat transferring pipe 3 connects a triple valve 5 by pipeline; Triple valve 5 connects the inlet of a cross valve 4 and an infusion pump 6 respectively by pipeline; Other three mouths of cross valve 4 connect a washing device 12 and two NaOH solution tank NaOHs 13,14 by pipeline respectively; The liquid outlet of preheating heat-changing tube 2 connects a triple valve 7 by pipeline, triple valve 7 connects the upper port and a cross valve 10 of an expansion bed 8 respectively by pipeline, other three mouths of cross valve 10 connect the liquid outlet of infusion pump 6, the lower port and an automatic collector 11 of expansion bed 8 respectively, cross valve 10 two ends on pipeline between expansion bed 8 lower port and automatic collector 11 inlets online detection and control device 9 in parallel detects and controls in order to the operating process to apparatus of the present invention.
Among the embodiment of said apparatus, except that the extractor 1 that uses the band heating jacket, can also adopt other extraction element, such as ultrasonic extraction device, Microwave Extraction device, percolating extractor, bionic extraction device and half bionic extraction device etc.
Among the embodiment of said apparatus, contain flushing liquor in the washing device 12, flushing liquor can be the ethanol of deionized water or various concentration, the flushing liquor that present embodiment adopts is a deionized water.Contain eluent in two NaOH solution tank NaOHs 13,14, eluent can adopt the ethanol of various concentration, and the eluent of present embodiment in NaOH solution tank NaOH 13 is that concentration is 30% ethanol, and the eluent in NaOH solution tank NaOH 14 is that concentration is 95% ethanol.Flushing liquor and eluent all are to change to some extent according to the needs that extract pharmaceutically active ingredient in the difference of separating in the practical application, this non-the present invention peculiar.
In the foregoing description, online detection and control device 9 comprises detector and two devices of controller, and wherein detector is a conventional equipment, and controller mainly is the switch of each valve of control, and with the flow direction of control liquid, it can be provided with as required according to a conventional method.In addition, the expansion bed 8 of the present invention's use can adopt the expansion bed of using in the prior art in other biological products purifying.Automatic collector 11 also can adopt one type of prior art syringe.
Embodiment 2:
By adopting the extraction separation of apparatus of the present invention to Chinese medicine cape jasmine active ingredient, describe the method for the integrated extraction separating effective Chinese medicine components of the present invention in detail, the inventive method may further comprise the steps:
(1) pulverizes 5g Chinese medicine cape jasmine, then it is put into the extractor 1 of being with heating jacket with conventional extractant (present embodiment adopts 50ml water), start heating jacket, the cape jasmine in the extractor 1 is decocted extraction;
(2) when the cape jasmine in the extractor 1 is decocted extraction, open infusion pump 6 (as shown in Figure 2), with the gardenia extract in the extractor 1, through cooling heat transferring pipe 3, triple valve 5 and cross valve 10, lower port by expansion bed 8 inputs in the expansion bed 8, after carrying out integrated separation, the surplus liquid of the gardenia extract after expansion bed 8 absorption, upper port by expansion bed 8 flows back in the extractor 1 through triple valve 7 and preheating heat-changing tube 2, continue to participate in decocting, extracting, formation is adsorbed on the interior resin of expansion bed body active ingredient to the Dynamic Extraction of extract;
(3) when cape jasmine constantly being decocted, extracting and in expansion bed 8, gardenia extract circulated absorption, start online detection controller 9, gardenia extract in the pipeline between expansion bed 8 lower port and the cross valve 10 is detected, and the liquid after the detection flow among the collecting pipe a in the automatic collector 11 as analyzing waste liquid.After cape jasmine active constituent content in the detected extract is lower than the setting value (specific requirement according to different Chinese medicines is determined) that provides in advance, stop decoction, extraction work in the extractor 1; Then by infusion pump 6 (as shown in Figure 3), with the flushing liquor in the washing device 12, through triple valve 4, triple valve 5 and cross valve 10, from bottom to top be delivered in the cylinder of expansion bed 8 from the lower port of expansion bed 8, with 2～3 times of flushing liquor flushing column body to column volume, flushing liquor also can be more, and flushing liquor carries solid particle and impurity component and flowed out by the upper port of expansion bed 8, in triple valve 7 and cross valve 10 flow to a collecting pipe b in the automatic collector 11;
(4) treat that step 3 flows into the flushing liquor clarification of automatic collector 11 after, by infusion pump 6 with the eluent in the NaOH solution tank NaOH 13 (as shown in Figure 4), through cross valve 4, triple valve 5, cross valve 10 and triple valve 7, from top to bottom be delivered in the cylinder of expansion bed 8 from the upper port of expansion bed 8, carry out wash-out with 5～6 times of eluents to column volume in to cylinder, by cross valve 10 eluent is collected among another collecting pipe c in the automatic collector 11 simultaneously, the eluent of this collection step contains the iridoid glycoside constituents in the cape jasmine active ingredient;
(5) in to the cylinder of expansion bed 8, carry out in the wash-out, utilize the online detection and control device, lower port to expansion bed 8 detects to the eluent in the pipeline between the cross valve 10, and the liquid after the detection flow among the collecting pipe a in the automatic collector 11 as analyzing waste liquid.When cape jasmine active constituent content in the detected eluent stops wash-out after being lower than the setting value that provides in advance, then by infusion pump 6 (as shown in Figure 5), with the eluent in the NaOH solution tank NaOH 14, through cross valve 4, triple valve 5, cross valve 10 and triple valve 7, from top to bottom be delivered in the cylinder of expansion bed 8 from the upper port of expansion bed 8, carry out wash-out with 5～6 times of eluents to column volume in to cylinder, and eluent is collected among the collecting pipe d again in the automatic collector 11 by cross valve 10, the eluent of this collection step contains the crocin constituents in the cape jasmine active ingredient, in wash-out crocin constituents, promptly finished to the cylinder of expansion bed 8 in the regeneration of resin process.
In this method embodiment, online detection and control device 9 promptly can detect cape jasmine active constituent content in the extract, can detect cape jasmine active constituent content in the eluent again, can also carry out control operation the device of whole integrated extraction separating effective Chinese medicine components.
Adopt the inventive method and device, Chinese medicine cape jasmine active ingredient is extracted the result of separation, compare with traditional extraction separation method, it extracts the index contrast situation following (as shown in table 1) of separating:
Table 1 the present invention is separating the situation contrast of 5g Chinese medicine cape jasmine active ingredient with conventional method
From the comparing result of above-mentioned table 1 as can be seen, the inventive method and device have that efficient height, step are simplified, the operating time shortly (only is 12.5% of traditional approach.), active ingredient obtains the ratio advantages of higher.
Embodiment 3:
Present embodiment is to 50g Chinese medicine cape jasmine, carries out integrated extraction by apparatus of the present invention and separates its active ingredient, and concrete method step is identical with embodiment 1, and it extracts the index and the conventional method contrast situation following (as shown in table 2) of separating:
Table 2 the present invention is separating the situation contrast of 50g Chinese medicine cape jasmine active ingredient with conventional method
From the comparing result of above-mentioned table 2 as can be seen, the inventive method and device have equally that efficient height, step are simplified, operational cycle time is short, active ingredient obtains the ratio advantages of higher when extracting separate larger.
Embodiment 4:
Present embodiment adopts apparatus of the present invention (as shown in Figure 1), the active ingredient of the integrated extraction separating traditional Chinese medicine red sage root, and its method may further comprise the steps:
1, pulverizes the 10g salviamiltiorrhizabung, then it is put into the extractor 1 that has heating jacket with conventional extractant (present embodiment adopts 100ml water), start heating jacket, the red sage root in the extractor 1 is decocted, extracts;
2, when the red sage root in the extractor 1 is decocted, extracts, open infusion pump 6 (as shown in Figure 2), with the red sage root extract in the extractor 1, through cooling heat transferring pipe 3, triple valve 5 and cross valve 10, input in the expansion bed 8 by the lower port of expansion bed 8, carry out integrated separation, the surplus liquid of the red sage root extract after expansion bed 8 absorption, upper port by expansion bed 8 is discharged, and flows back in the extractor 1 through triple valve 7 and preheating heat-changing tube 2 then, continues to participate in decocting, extracting;
3, when the red sage root constantly being decocted, extracting and in expansion bed 8, red sage root extract circulated absorption, start online detection controller 9, red sage root extract in the pipeline between expansion bed 8 lower port and the cross valve 10 is detected, and the liquid after the detection flow among the collecting pipe a in the automatic collector 11 as analyzing waste liquid.After danshinolic acid in the detected extract-B content is lower than setting value (specific requirement according to different Chinese medicines is determined), stop decoction, extraction work in the extractor 1; Then by infusion pump 6 (as shown in Figure 3) with the flushing liquor in the washing device 12 (flushing liquor that present embodiment adopts is a deionized water), through triple valve 4, triple valve 5 and cross valve 10, from bottom to top be delivered in the cylinder of expansion bed 8 from the lower port of expansion bed 8, with 2～3 times of water yield flushing column body to column volume, flushing liquor can also be more, flushing liquor carries solid particle and impurity component is gone out by the upper port of expansion bed 8, then in triple valve 7 and cross valve 10 flow to a collecting pipe b in the automatic collector 11;
4, after treating the flushing liquor clarification of step 3, as shown in Figure 4, by infusion pump 6 with the eluent in the NaOH solution tank NaOH 13 (eluent of present embodiment contain in NaOH solution tank NaOH 13 is that concentration is 50% ethanol), through cross valve 4, triple valve 5, cross valve 10 and triple valve 7, from top to bottom be delivered in the cylinder of expansion bed 8 from the upper port of expansion bed 8, carry out wash-out with 5～6 times of ethanol waters to column volume in to cylinder, by cross valve 10 eluent is collected among another collecting pipe c in the automatic collector 11 simultaneously, the eluent of this collection step contains the danshinolic acid constituents in the effective component in red sage;
5, in to the cylinder of expansion bed 8, carry out in the wash-out, utilize online detection and control device 9, eluent in the closed conduct between cross valve 10 and the automatic collector 11 is detected, and the liquid after the detection flow among the collecting pipe a in the automatic collector 11 as analyzing waste liquid.After danshinolic acid in the detected eluent-B content is lower than setting value, stop wash-out, then by infusion pump 6 (as shown in Figure 5) with the eluent in the NaOH solution tank NaOH 14 (eluent of present embodiment contain in NaOH solution tank NaOH 14 is that concentration is 95% ethanol), through cross valve 4, triple valve 5, cross valve 10 and triple valve 7, from top to bottom be delivered in the cylinder of expansion bed 8 from the upper port of expansion bed 8, with 5 times of concentration to column volume be 95% ethanol to the cylinder of expansion bed 8 in resin regenerate, and eluent is collected among the collecting pipe d again in the automatic collector 11 by cross valve 10.
Present embodiment adopts the inventive method and device, and the Chinese medicine effective component in red sage is extracted the result of separation, compares with traditional extraction separation method, and it extracts the index contrast situation following (as shown in table 3) of separating:
Table 3 the present invention and conventional method are in the situation contrast of separating traditional Chinese medicine effective component in red sage
From the comparing result shown in the table 3 as can be seen, the inventive method and device still have advantages such as efficient height, step simplification, operational cycle time weak point in the extraction to the Chinese medicine effective component in red sage separates.
Claims (5)
1, a kind of method of integrated extraction separating effective Chinese medicine components, it may further comprise the steps:
(1) with after the Chinese medicine pulverizing, places extraction element, add extractant, extract;
(2) when extracting, open infusion pump, extract from bottom to top is delivered in the expansion bed cylinder, adsorb surplus liquid after the preheating heat-changing tube preheating, flow back into and continue to participate in traditional Chinese medicine extraction in the extraction element, formation is adsorbed on the interior resin of expansion bed body active ingredient to the Dynamic Extraction of extract;
(3) treating that the online detection and control device detects in the extract stops to extract after target component content is lower than setting value, by infusion pump flushing liquor from bottom to top is delivered in the cylinder of expansion bed from expansion bed bottom, solid particle and impurity is gone out sent into automatic collector;
(4) treat flushing liquor clarification after, by infusion pump eluant, eluent from top to bottom is delivered to from the expansion bed top in the cylinder of expansion bed, collect eluent simultaneously in described automatic collector;
(5) treat that the online detection and control device detects that target component content stops wash-out after being lower than setting value in the eluent, from top to bottom be delivered to another eluant, eluent in the cylinder of expansion bed from the expansion bed top by infusion pump, finish the regenerative process of post, collect eluent simultaneously in described automatic collector.
2, the method for a kind of integrated extraction separating effective Chinese medicine components as claimed in claim 1 is characterized in that: described extraction element for the band heating jacket extractor, ultrasonic extraction device, Microwave Extraction device, percolating extractor, bionic extraction device and half bionic extraction device in a kind of.
3, the method for a kind of integrated extraction separating effective Chinese medicine components as claimed in claim 1 is characterized in that: described target component refers to the described Effective Components of Chinese Herb of preextraction or separation.
4, a kind of device of integrated extraction separating effective Chinese medicine components, it is characterized in that, it comprises: an extraction element, one heat exchanger, be provided with preheating heat-changing tube and cooling heat transferring pipe in it, described extraction element connects the inlet of described preheating heat-changing tube and cooling heat transferring pipe respectively by pipeline, the liquid outlet of described cooling heat transferring pipe connects first triple valve by pipeline; Described first triple valve connects the inlet of first cross valve and an infusion pump respectively by pipeline; Other three mouths of this cross valve connect a washing device and two NaOH solution tank NaOHs by pipeline respectively; The liquid outlet of described preheating heat-changing tube connects second triple valve by pipeline, described second triple valve connects the upper port and second cross valve of an expansion bed respectively by pipeline, other three mouths of this second cross valve connect the liquid outlet of described infusion pump, the lower port and an automatic collector of expansion bed respectively, the online detection and control device in parallel of the cross valve two ends on pipeline between described expansion bed lower port and the described automatic collector inlet.
5, the device of a kind of integrated extraction separating effective Chinese medicine components as claimed in claim 4 is characterized in that: a kind of in extractor, ultrasonic extraction device, Microwave Extraction device, percolating extractor, bionic extraction device and the half bionic extraction device of described extraction element for the band heating jacket.
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| CN101780114A (en) * | 2010-03-17 | 2010-07-21 | 华东理工大学 | Extraction and separation method of effective constituents of traditional Chinese medicine |
| CN104892796B (en) * | 2015-06-09 | 2017-08-18 | 齐鲁工业大学 | The streaming separator and method of agricultural-forestry biomass chemical constituent |
| CN109021040B (en) * | 2018-05-25 | 2021-09-07 | 无锡济煜山禾药业股份有限公司 | Continuous chromatographic separation and purification method of geniposide |
| CN116622477A (en) * | 2023-07-25 | 2023-08-22 | 江中药业股份有限公司 | Extraction system, liquid extraction method and device |
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| KR20020052564A (en) * | 2000-12-26 | 2002-07-04 | 변유량 | Method of expanded bed adsorption-ion exchange chromatography |
| CN1704398A (en) * | 2004-05-26 | 2005-12-07 | 中国科学院过程工程研究所 | Method for one-step purification and separation of ephedrine by cation exchange resin and expanded bed integrated technology |
| CN200966767Y (en) * | 2006-11-10 | 2007-10-31 | 清华大学 | Integrated device for distilling the effective component from the Chinese traditional medicine |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| KR20020052564A (en) * | 2000-12-26 | 2002-07-04 | 변유량 | Method of expanded bed adsorption-ion exchange chromatography |
| CN1704398A (en) * | 2004-05-26 | 2005-12-07 | 中国科学院过程工程研究所 | Method for one-step purification and separation of ephedrine by cation exchange resin and expanded bed integrated technology |
| CN200966767Y (en) * | 2006-11-10 | 2007-10-31 | 清华大学 | Integrated device for distilling the effective component from the Chinese traditional medicine |
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