CN205740995U - A kind of universal type replaceable nucleic acid extraction magnetic frame - Google Patents
A kind of universal type replaceable nucleic acid extraction magnetic frame Download PDFInfo
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- CN205740995U CN205740995U CN201620546077.3U CN201620546077U CN205740995U CN 205740995 U CN205740995 U CN 205740995U CN 201620546077 U CN201620546077 U CN 201620546077U CN 205740995 U CN205740995 U CN 205740995U
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Abstract
This utility model provides a kind of universal type replaceable nucleic acid extraction magnetic frame, including base, pad, and assigns in base, the magnetic bar of pad draw-in groove.Meeting the base of ANSI/SBS international norm, pad specification and draw-in groove arrangement makes magnetic frame can be widely used in automatization, high-throughput nucleic acid extraction.Pad can adjust the effective length of magnetic bar.Magnetic bar is by 4 × 6 row arrangements, with longitudinal section for S pole and N pole separating surface, the equal distributed magnetic field in side, and adsorbable deep hole extracts the biomagnetic beads in plate.Magnetic bar uses N52 intensity neodymium iron boron permanent magnetism Magnet, and magnetic force is strong, energy high-efficiency accumulation magnetic bead, and avoids electric magnet heat production in use, reduces the infringement to biological sample.Magnetic bar can the most single assign in draw-in groove, it is to avoid it is vacant that magnetic bar damages the magnetic frame caused, and greatly improves the service efficiency of magnetic frame.Around the conjunction the action of a magnetic field of magnetic bar can automatic orientation magnetic bar, it is to avoid the magnetic bead absorption disorder that magnetic field disorder causes.
Description
Technical field
This utility model relates to a kind of biotinylated nucleic acid extraction equipment, especially relates to a kind of universal type replaceable nucleic acid extraction
Magnetic frame.
Background technology
Along with modern biotechnology and the development of medical science, high flux extracts nucleic acid and has become as biological relevant area research
One of important means.Paramagnetic particle method extract nucleic acid because of its high flux, automatization advantage increasingly by biosphere and related discipline
Extensive application.
Magnetic frame is during paramagnetic particle method extracts nucleic acid, is used for producing the capital equipment of externally-applied magnetic field, it is possible to realize magnetic
Pearl in magnetic field assemble rapidly and leave behind magnetic field the most dispersed.Therefore, the architectural feature of magnetic frame is to paramagnetic particle method
Extract nucleic acid experiment impact great.
At present, though existing magnetic frame product can partly meet user's requirement on market, but a lot of deficiency is still suffered from.Including:
1. can carry number few, specification is not fixed.Existing magnetic frame, in particular for the magnetic force of 1.5-2mL specification extraction tube
Frame only has minority reagent pore to be used for carrying extraction tube mostly, and the arrangement of magnetic frame specification, reagent pore is without a fixed pattern, no
Can meet high flux, automatization extracts requirement.
2. magnetic bar acting surface is limited.The action of a magnetic field area of the internal magnetic bar of existing magnetic frame is less, causes magnetic bead big
Amount is gathered in bottom extraction tube, or extracts tube wall somewhere, it is impossible to carries out sample waste separation well, more even causes magnetic bead
Lose and affect nucleic acid yield.
3. magnetic bar magnetic field intensity is weak.Magnetic bar magnetic field intensity is weak, cause magnetic bead assemble slow and loose, affect magnetic bead and
Efficiently separating of waste liquid, even causing magnetic bead to lose affects nucleic acid yield.
4. magnetic bar designs integration with magnetic force frame base, can not separate and change.Once magnetic bar is damaged, by shadow
Ring the service efficiency of whole magnetic frame.
5. magnetic bar and reagent pore are fixed, it is impossible to meet the demand of different model specification extraction tube simultaneously.
Utility model content
For solving the problems referred to above, this utility model provides a kind of magnetic frame reliable, general, removable, really solves
Magnetic frame can carry that number is few, magnetic bar acting surface is limited, magnetic field intensity is weak, magnet present in the biotinylated nucleic acid extraction process
Integration, the problem that can not separate and change, can not meet different model specification extraction tube demand, thus really is designed with base
Achieve magnetic frame high flux during nucleic acid extraction, generalization and automatization.
This utility model solves its technical problem and be the technical scheme is that a kind of universal type replaceable nucleic acid extraction magnetic
Power frame, it is characterised in that: including base, pad and magnetic bar, described pad covers and is all provided with at base upper surface, base and pad
Having some draw-in grooves, described draw-in groove is overlapping on base and pad, and draw-in groove has been assigned magnetic bar.
Being further used as the improvement of technical solutions of the utility model, described base is aerolite material.
Being further used as the improvement of technical solutions of the utility model, described base specification is 127.76mm × 85.48mm, symbol
Closing ANSI/SBS international norm, all there is the corner cut of a 2mm each limit of upper surface and corner.
Being further used as the improvement of technical solutions of the utility model, described base upper surface is provided with draw-in groove.
Being further used as the improvement of technical solutions of the utility model, described pad is acrylic material, and thickness can be according to reality
Test consumptive material to be adjusted, usually 3mm.
Being further used as the improvement of technical solutions of the utility model, described pad specification is consistent with base.
Being further used as the improvement of technical solutions of the utility model, described draw-in groove is 4 × 6 row arrangements, and card inter-alveolar distance is
18mm。
Being further used as the improvement of technical solutions of the utility model, described draw-in groove is diameter 3.05mm, the degree of depth on base
The cylinder shape groove of 10mm.
Being further used as the improvement of technical solutions of the utility model, described draw-in groove can assign a magnetic bar.
Being further used as the improvement of technical solutions of the utility model, described magnetic bar is neodymium iron boron permanent magnetism Magnet.
Being further used as the improvement of technical solutions of the utility model, described magnetic bar magnetic field intensity is N52 rank.
Being further used as the improvement of technical solutions of the utility model, described magnetic bar is demarcated with longitudinal section for S pole and N pole
Face, the equal distributed magnetic field in side.
Being further used as the improvement of technical solutions of the utility model, described magnetic bar is the cylinder of diameter 3mm, highly 26mm
Body.
The beneficial effects of the utility model: the base specification meeting ANSI/SBS international norm in this utility model is magnetic force
The generally applicable self-reacting device of frame provides possibility, in order to carry out high flux, automatic nucleic acid extracts.At the bottom of aerolite material
Seat has high-strength, the advantage of high-ductility, improved corrosion, it is possible to pressure, impact force and the corrosion being effective against in experimentation.Base
Magnetic frame can be fixed on instrument by the corner cut of corner by the fixing device on automatic instrument for extracting nucleic acid, and the corner cut on four limits can
So that the nucleic acid extraction plate meeting ANSI/SBS international norm is fixed on magnetic frame.The draw-in groove that base is arranged can freely be assigned
Magnetic bar, for the replacing of damaged magnetic bar, improves the service efficiency of magnetic frame, and magnetic bar can be carried out according to surrounding magnetic field
Self poisoning, it is to avoid the magnetic bead distribution disorders caused owing to magnetic direction changes.Magnetic bar uses the neodymium iron boron of N52 intensity forever
Magnetic Magnet for a long time, magnetic field intensity is big, energy high-efficiency accumulation magnetic bead, makes magnetic bead form single linear arrangement in closing magnetic field, facilitates core
Acid separates with waste liquid, and Magnet avoids the heat that electric magnet energising produces during extracting, the less damage to biomaterial.
Magnetic bar with longitudinal section for S pole and N pole separating surface, the equal distributed magnetic field in side, the magnetic bar surrounding four holes to there being deep-well plates
Position, the open by design of non-extraction tube enables magnetic frame to be suitable for the deep-well plates of different depth specification, improves making of magnetic frame
Use efficiency.Magnetic frame is equipped with acrylic material pad, it is possible to change the effective length of magnetic bar so that it is be suitable for different depth
Deep-well plates is extracted.This utility model uses reliable, it is easy to install, and solves current biotinylated nucleic acid extraction magnetic frame and can carry number
Less, magnetic bar acting surface is limited, magnetic field intensity is weak, magnet designs integration with base, can not separate, replaces and can not expire simultaneously
The problem of the extraction tube of foot different model specification, thus be truly realized magnetic frame high flux during nucleic acid extraction, lead to
With changing and automatization.
Accompanying drawing explanation
The utility model is described in further detail below in conjunction with the accompanying drawings.
Fig. 1 is this utility model magnetic frame structural representation；
Fig. 2 is this utility model magnetic frame top view；
Fig. 3 is this utility model magnetic frame vertical structure schematic diagram；
Fig. 4 is this utility model magnetic frame longitudinal sectional view；
Fig. 5 is this utility model magnetic frame transversary schematic diagram；
Fig. 6 is this utility model magnetic frame transverse sectional view.
Detailed description of the invention:
Referring to figs. 1 through Fig. 6, that show the concrete structure of the preferred embodiment of this utility model.Below will specifically
The construction features of each element of bright this utility model, and if when being described direction (upper and lower, left and right, before and after), be with Fig. 1
Shown structure is with reference to describing, but actually used direction of the present utility model is not limited thereto.
This utility model provides a kind of universal type replaceable nucleic acid extraction magnetic frame, including base 1, base upper surface
Pad 2 and assign the magnetic bar 3 on base 1 and pad 2.Base 1 uses aerolite material to constitute, and material is high-strength, high
Tough, improved corrosion, is highly resistant to pressure, impact force and the corrosion of corrosive goods confrontation magnetic frame in experiment.Base 1 specification
Meeting ANSI/SBS international norm, upper surface four limit is respectively provided with a 2mm corner cut, is used for fixing 96 holes and extracts plate, base corner
It is respectively arranged with a 2mm corner cut, it is possible to by the fixing device of automatic instrument for extracting nucleic acid, base is fixed on automatic instrument for extracting nucleic acid,
It is easy to automation mechanized operation.Base upper surface distance horizontal boundary 16mm, is provided with 4 × 6 row circle draw-in grooves 4 at longitudinal boundary 19mm,
Between draw-in groove 4, spacing is 18mm, and arrangement meets ANSI/SBS international norm.Draw-in groove 4 can assign the magnetic bar 3 of diameter 3mm.Pad
Sheet 2 uses acrylic material, covers at magnetic force frame base 1 upper surface.On pad 2, draw-in groove 4 size and location is overlapping with base 1,
The effective length of magnetic bar 3 can be adjusted by pad 2, adjust magnetic field size, and acrylic material can buffer experimental pressure,
Opposing corrosion.The described a diameter of 3.05mm of draw-in groove 4, on base 1, the degree of depth is 10mm, it is possible to freely firmly assign diameter 3mm
Magnetic bar 3.Described magnetic bar 3 is diameter 3mm, the cylinder of high 26mm.Magnetic bar 3 material be the neodymium iron boron of N52 intensity forever
Property Magnet for a long time, with longitudinal section for S pole and N pole separating surface, the equal distributed magnetic field in side.Magnetic bar 3 can be by magnetic each other
Field action automatic orientation is also fixed on draw-in groove 4.Free style single insertion magnetic bar 3 decreases to the full extent due to magnetic bar
The idle waste of the magnetic frame damaged and cause.Non-extraction pore open by design makes magnetic frame can be simultaneously suitable for different rule
The deep-well plates of lattice number.
Certainly, this utility model is not limited to above-mentioned embodiment, and those of ordinary skill in the art are without prejudice to this
Also can make equivalent variations or replacement on the premise of utility model spirit, modification or the replacement of these equivalents are all contained in the application
In claim limited range.
Claims (13)
1. a universal type replaceable nucleic acid extraction magnetic frame, it is characterised in that: include base, pad and magnetic bar, described pad
Sheet covers and is equipped with some draw-in grooves at base upper surface, base and pad, and described draw-in groove is overlapping, on draw-in groove on base and pad
Assign magnetic bar.
Magnetic frame the most according to claim 1, it is characterised in that: described base is aerolite material.
Magnetic frame the most according to claim 1, it is characterised in that: described base specification is 127.76mm × 85.48mm, symbol
Closing ANSI/SBS international norm, all there is the corner cut of a 2mm each limit of upper surface and corner.
Magnetic frame the most according to claim 1, it is characterised in that: described base upper surface is provided with draw-in groove.
Magnetic frame the most according to claim 1, it is characterised in that: described pad is acrylic material, and thickness can be according to reality
Test consumptive material to be adjusted, usually 3mm.
Magnetic frame the most according to claim 1 or 5, it is characterised in that: described pad specification is consistent with base.
7. according to the magnetic frame described in claim 1 or 4, it is characterised in that: described draw-in groove is 4 × 6 row arrangements, card inter-alveolar distance
For 18mm.
8. according to the magnetic frame described in claim 1 or 4, it is characterised in that: described draw-in groove is diameter 3.05mm, deep on base
The cylinder shape groove of degree 10mm.
Magnetic frame the most according to claim 8, it is characterised in that: described draw-in groove can assign a magnetic bar.
10. according to the magnetic frame described in claim 1 or 9, it is characterised in that: described magnetic bar is neodymium iron boron permanent magnetism magnetic
Ferrum.
11. according to the magnetic frame described in claim 1 or 9, it is characterised in that: described magnetic bar magnetic field intensity is N52 rank.
12. according to the magnetic frame described in claim 1 or 9, it is characterised in that: described magnetic bar divides with longitudinal section for S pole and N pole
Interface, the equal distributed magnetic field in side.
13. according to the magnetic frame described in claim 1 or 9, it is characterised in that: described magnetic bar is diameter 3mm, highly 26mm
Cylinder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620546077.3U CN205740995U (en) | 2016-06-01 | 2016-06-01 | A kind of universal type replaceable nucleic acid extraction magnetic frame |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620546077.3U CN205740995U (en) | 2016-06-01 | 2016-06-01 | A kind of universal type replaceable nucleic acid extraction magnetic frame |
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| CN205740995U true CN205740995U (en) | 2016-11-30 |
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| CN201620546077.3U Active CN205740995U (en) | 2016-06-01 | 2016-06-01 | A kind of universal type replaceable nucleic acid extraction magnetic frame |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106906121A (en) * | 2017-04-17 | 2017-06-30 | 新疆出入境检验检疫局检验检疫技术中心 | The nucleic acid separator and separation method of magnet control |
| CN107012198A (en) * | 2017-05-25 | 2017-08-04 | 杭州富集生物科技有限公司 | A kind of replaceable magnetic frame that pathogen is enriched with for paramagnetic particle method |
| CN107287114A (en) * | 2017-07-01 | 2017-10-24 | 中山大学 | The magnetic separating device and method of a kind of biological specimen |
| CN107974394A (en) * | 2018-01-22 | 2018-05-01 | 无锡百泰克生物技术有限公司 | A kind of instrument for extracting nucleic acid |
-
2016
- 2016-06-01 CN CN201620546077.3U patent/CN205740995U/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106906121A (en) * | 2017-04-17 | 2017-06-30 | 新疆出入境检验检疫局检验检疫技术中心 | The nucleic acid separator and separation method of magnet control |
| CN107012198A (en) * | 2017-05-25 | 2017-08-04 | 杭州富集生物科技有限公司 | A kind of replaceable magnetic frame that pathogen is enriched with for paramagnetic particle method |
| CN107012198B (en) * | 2017-05-25 | 2023-12-01 | 杭州富集生物科技有限公司 | Replaceable magnetic rack for enriching pathogens by magnetic bead method |
| CN107287114A (en) * | 2017-07-01 | 2017-10-24 | 中山大学 | The magnetic separating device and method of a kind of biological specimen |
| CN107974394A (en) * | 2018-01-22 | 2018-05-01 | 无锡百泰克生物技术有限公司 | A kind of instrument for extracting nucleic acid |
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