CN202786253U - Automatic blood culture instrument - Google Patents
Automatic blood culture instrument Download PDFInfo
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- CN202786253U CN202786253U CN 201220417934 CN201220417934U CN202786253U CN 202786253 U CN202786253 U CN 202786253U CN 201220417934 CN201220417934 CN 201220417934 CN 201220417934 U CN201220417934 U CN 201220417934U CN 202786253 U CN202786253 U CN 202786253U
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- blood culture
- temperature
- culture instrument
- automated blood
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Abstract
The utility model relates to an automatic blood culture instrument which comprises a culture system, culture flasks, a detection system and a computer control system, wherein the culture system comprises an automatic constant-temperature incubator body, as well as an oscillation mechanism module, a temperature control module and a slot module, which are all located in the incubator body; the culture flasks are arranged in the slot module; and the computer control system mainly comprises an embedded computer embedded in the automatic constant-temperature incubator body. According to the utility model, the temperature control system can ensure optimal temperature for growth of bacteria in the culture flasks, and an oscillation system can ensure uniform mixing of culture solution in the culture flasks; prompt positive report is realized, and 85 percent of positive samples can be detected out in 48 hours; and the false positive report probability is low, normally not more than 0.5 percent.
Description
Technical field
The utility model relates to a kind of medicine equipment, and in particular, the utility model relates to a kind of Automated blood culture instrument.
Background technology
Because the progress of medical skill, various diagnoses and treatment means grow with each passing day, such as organ transplantation, being widely used of antitumor drug, Broad spectrum antibiotics, immunosuppressor, various Interventional examination treatments, intravenous hyperalimentation and other catheter retaining etc. all are creating conditions of microbemia, septicemia.Microbemia and septicemia disease time are rapid, and mortality ratio is higher.
The incidence of blood infection obviously increases over nearly 20 years, by rising to present 13% 6% of the end of the year 70.Because microbemia and septicemia are the diseases that seriously jeopardizes clinically patient's life, mortality ratio is up to 29%, and the blood microbial culture is the important evidence of establishing microbemia and Diagnosis of Septicemia, the pathogenic bacteria of clear and definite septicemia, most important to clinical targeted antibacterial therapy, can effectively reduce case fatality rate, improve curative ratio.
The nineties in 20th century, Holland-U.S. Organon Teknika Corp released Bact/Alert Full-automatic blood culture instrument device.This system is comprised of with the computer of the aerobic of carbonic acid gas susceptor with anaerobism culturing bottle and the work of control whole system one or more incubators.The principle of work of this system is to be equipped with a carbonic acid gas susceptor with moisture indicator in each culturing bottle bottom, and this indicator is green at alkaline state, and the reduction along with the pH value becomes yellow by green gradually.In susceptor and bottle, sealed one deck ion exclusion film between the liquid nutrient medium.This film only allows carbon dioxide to pass through, and other composition in the liquid nutrient medium comprises that free hydrogen ion all can not pass through.After in the substratum bacterial growth being arranged, the CO that produces
2By behind the film with the susceptor indicator on saturated steeping in water for reconstitution give birth to reaction and produce free hydrogen ion, the pH value is changed, the color of susceptor also changes thereupon, and color is by original green yellowing, and this process is by a Light-Echo detection meter continuous monitoring that places detection components inside.The major advantage of B/A system has: continuously, non-invasively automatically monitor microbial growth situation in the culturing bottle; And detection efficiency is high.
The application of full-automatic hemoculture technology has significantly alleviated the workload in laboratory, and can make the hemoculture report time than manual bottle in advance.Although hemoculture instrument has plurality of advantages, be developing direction from now on, import hemoculture instrument and corresponding Blood culture bottle price are very expensive, and at present domestic only part large hospital uses.But at present domesticly also do not recognize have related personnel or mechanism that full-automatic hemoculture system was carried out research and development.This detecting instrument is at medical and health organizations such as hospital, blood bank, laboratories, and pharmacy, food, the aspects such as biological hatching all can have widely application, and have that volume is little, lightweight, power saving and the advantage such as easy to use, so have great market outlook.But its development still is subject to the restriction of many factors.For example sensitivity is high not enough, pollution rate and false positive rate also remain to be reduced; Equipment cost and use cost also remain further to be reduced etc.
The utility model content
In order to solve unstable, the testing cost high-technology problem of existing positive rate in the prior art, the utility model provides a kind of Automated blood culture instrument, there are one group of lighting unit and probe unit in system of the present utility model in the bottom, placement position of each culturing bottle, lighting unit adopts photodiode (LED) as light source, can improve the stability of test set, metastable light intensity and reduce use cost.
In order to solve the problems of the technologies described above, the utility model has adopted following technical scheme:
A kind of Automated blood culture instrument comprises culture systems, culturing bottle, detection system and computer control system, described culture systems comprise the automatic constant-temperature incubator casing, be positioned at concussion mechanism module, temperature control modules and the socket module of casing; Described culturing bottle is arranged in the socket module; Described computer control system mainly is made of the embedded computer in the casing that is embedded in the automatic constant-temperature incubator.
In described Automated blood culture instrument, all has said detecting system in the automatic bottom of each culturing bottle of hemoculture device.
In described Automated blood culture instrument, also comprise Peripheral Interface in the casing of described automatic constant-temperature incubator, Peripheral Interface is connected with indicating meter and bar-code scanner.
In described Automated blood culture instrument, described concussion mechanism module comprises stepper motor driver, stepper-motor, eccentric mechanism and safety door switch.Stepper motor driver is by the 24V DC power supply, by the Computer I/O card control, start-stop state, travel position and the traffic direction of stepper-motor is to control by IO point high-low level, the rotating of motor drives eccentric mechanism and rotates at a certain angle, and then makes the uniform liquid concussion in the culturing bottle.
In described Automated blood culture instrument, described temperature control modules comprises power panel, thermopair, ptc heater, radiator fan and display panel.
In described Automated blood culture instrument, described embedded computer is connected with temperature control modules, concussion mechanism module, detection system, bar-code scanner and indicating meter respectively, with realization blood preparation is cultivated, is detected in the environment of constant temperature, concussion.Variation in the culturing bottle by continuously, automatically the monitoring, measured signal is transferred into computer analysis.Can show in real time the microbial growth situation by indicating meter, draw growth curve, the sample positive of making promptly and accurately reports that in case the anode result occurs, computer gives the alarm automatically, the position of the positive bottle of indication, and record the positive time of appearance etc.
In described Automated blood culture instrument, described testing circuit comprises pre-amplification circuit, main amplifying circuit and demodulator circuit.Pre-amplification circuit is increased to certain level with the amplitude of signal and noise, and main amplifying circuit carries out linear amplification, and demodulator circuit carries out square wave solution mediation AD conversion with amplifying signal, and the signal that then enters system control sytsem is digital quantity.For instance, if the voltage change scope of demodulation output is the 0-3 volt, and adopt 12 AD, then the resolving power of light intensity variable quantity is 1/4096, this shows, adopts detection system of the present utility model can obtain high accuracy of detection.
Compared with prior art, the utlity model has following useful technique effect:
1, the temperature control system of this novel cultivation instrument can guarantee that the bacterium in the culturing bottle grows (35 ℃～37 ℃) in optimum temps, the even mixing of nutrient solution in the concussion System Assurance culturing bottle.
2, positive report is timely, and 85% positive sample can be detected in 48 hours; False positive rate is low, usually is not higher than 0.5%.
3, instrument of the present utility model can be 10-30 ℃ in peripheral temperature, and peripheral relative humidity is to work under the condition of 10-90%, less demanding to environment, thereby easy to use, be easy to management.
Description of drawings
Fig. 1: split structural representation Fig. 1 in the Automated blood culture instrument casing of the utility model embodiment;
Fig. 2: split structural representation Fig. 2 in the Automated blood culture instrument casing of the utility model embodiment;
Fig. 3: the fundamental diagram of concussion mechanism module in the utility model;
Fig. 4: the control flow chart of concussion mechanism module in the utility model;
Fig. 5: the fundamental diagram of temperature control modules in the utility model;
Fig. 6: the control flow chart of temperature control modules in the utility model;
Fig. 7: system's control overall structure block diagram in the utility model;
Fig. 8: system controls overall electrical schematic in the utility model;
The implication of Reference numeral representative is respectively among the figure: 1, the casing of automatic constant-temperature incubator, 2, the concussion mechanism module, 3, socket module, 4, embedded computer, 5, detection system, 6, temperature control modules, 7, Peripheral Interface.
Embodiment
Below in conjunction with accompanying drawing and specific embodiment the technical solution of the utility model is described in detail, but accompanying drawing and specific embodiment be not as the restriction to the utility model patent.
Shown in Fig. 1-2, present embodiment relates to a kind of Automated blood culture instrument, comprise culture systems, culturing bottle, detection system 5 and computer control system, described culture systems comprises the casing 1 of automatic constant-temperature incubator, the concussion mechanism module 2 that is positioned at casing, temperature control modules 6 and socket module 3, described culturing bottle is arranged in the socket module 3, and described computer control system mainly is made of the embedded computer 4 in the casing 1 that is embedded in the automatic constant-temperature incubator.
Also comprise Peripheral Interface 7 in the casing 1 of described automatic constant-temperature incubator, Peripheral Interface 7 is connected with indicating meter and bar-code scanner.
As shown in Figure 3, described concussion mechanism module 2 main stepper motor driver, stepper-motor, eccentric mechanism and the safety door switchs of comprising form.Stepper motor driver is by the 24V DC power supply, by the Computer I/O card control; Start-stop state, travel position and the traffic direction of stepper-motor is to control by IO point high-low level; Safety door switch is the precondition as the stepper-motor operation.If safety door switch is closed, the IO point of pulse signal and direction signal is paramount, then stepper motor driver control step motor moves to certain position (if change motor phase line connection, paramount then counter-rotating) with certain pulse forward, to hanging down then return motion to certain position.The rotating of motor drives eccentric mechanism and rotates at a certain angle, and then makes the uniform liquid concussion in the culturing bottle.The schema of described concussion mechanism module 2 controls as shown in Figure 4.
As shown in Figure 5, described temperature control modules 6 comprises power panel, thermopair, ptc heater, radiator fan, display panel and LED light.Thermopair sensing the temperature inside the box, and feed back to power panel, lower than set(ting)value if temperature sensor detects the temperature inside the box, then well heater begins heating, until the temperature inside the box equals design temperature, the PTC well heater is stopped heating; Whole process radiator fan moves always; The running status of display panel indication temperature control box.If the running status of LED lamp indication temperature control box bright, then is in running status; If go out, then be in the state that quits work that cuts off the power supply.The control flow chart of described temperature control modules 6 as shown in Figure 6.
As shown in Figure 7, described embedded computer 4 is connected with temperature control modules 6, concussion mechanism module 2, detection system 5, bar-code scanner and indicating meter respectively, with realization blood preparation is cultivated, is detected in the environment of constant temperature, concussion.Variation in the culturing bottle by continuously, automatically the monitoring, measured signal is transferred into computer analysis.Can show in real time the microbial growth situation by indicating meter, draw growth curve, the sample positive of making promptly and accurately reports that in case the anode result occurs, computer gives the alarm automatically, the position of the positive bottle of indication, and record the positive time of appearance etc.The whole system schematic circuit is divided into four large branch roads substantially as shown in Figure 8, and each branch road is protected with the isolating switch of suitable electric current respectively.The first branch road provides power supply for temperature control box, and temperature control box and PC are by the RS485 communication simultaneously, and PC reaches temperature control box with design temperature, and temperature control box feeds back to PC with Current Temperatures; The second branch road is 24VDC pilot circuit and oscillator control section, and the 24V D.C. regulated power supply is mainly stepper motor driver, each limit switch and safety detection switch etc. power supply is provided.The 3rd branch road is the 5VDC power control part, is mainly detection system 5 power supply of station, and blood detection system 5 will collect analog signals and transfer to A/D card in the computer, be converted to numerary signal, judge that blood presents feminine gender or the positive; The 4th branch road is that embedded computer 4 power supplies and peripherals connect.
The principle of work of Automated blood culture instrument of the present utility model and workflow:
After culturing bottle put into instrument, just begin constant temperature (35 ℃～37 ℃) and shake continuously (60 beats/mins) culturing process, one group of LED laser apparatus and reflected light inductor block are arranged at the bottom, placement position of each culturing bottle, every lO minute automatic l time (144 times/days) bottle Novel CO at end that detects
2The change of susceptor color.After signal was delivered to computer, the Automatic continuous memory was also made graphic representation, judges yin and yang attribute by computer for analysis, and positive in time gives the alarm, and did not give birth to the elder and sent negative report in 5～7 days.
The above; it only is preferred embodiment of the present utility model; can not be interpreted as limiting scope of the present utility model with this, the embodiment of all distortion that is equal to of making in the claimed scope of claims of the present utility model and change is all in the utility model scope required for protection.
Claims (6)
1. Automated blood culture instrument, comprise culture systems, culturing bottle, detection system (5) and computer control system, it is characterized in that described culture systems comprises the casing (1) of automatic constant-temperature incubator, the concussion mechanism module (2) that is positioned at casing, temperature control modules (6) and socket module (3), described culturing bottle is arranged in the described socket module (3), and described computer control system is made of the embedded computer (4) in the casing 1 that is embedded in the automatic constant-temperature incubator.
2. Automated blood culture instrument according to claim 1 is characterized in that all having a described detection system (5) in the bottom of each culturing bottle.
3. Automated blood culture instrument according to claim 1 it is characterized in that also comprising Peripheral Interface (7) in the casing (1) of described automatic constant-temperature incubator, and described Peripheral Interface (7) is connected with indicating meter and bar-code scanner.
4. each described Automated blood culture instrument is characterized in that described concussion mechanism module (2) comprises stepper motor driver, stepper-motor, eccentric mechanism and safety door switch according to claim 1-3.
5. each described Automated blood culture instrument is characterized in that described temperature control modules (6) comprises power panel, thermopair, ptc heater, radiator fan and display panel according to claim 1-3.
6. Automated blood culture instrument according to claim 3 is characterized in that described embedded computer is connected with temperature control modules (6), concussion mechanism module (2), detection system (5), bar-code scanner and indicating meter respectively.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220417934 CN202786253U (en) | 2012-08-22 | 2012-08-22 | Automatic blood culture instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220417934 CN202786253U (en) | 2012-08-22 | 2012-08-22 | Automatic blood culture instrument |
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| CN202786253U true CN202786253U (en) | 2013-03-13 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 201220417934 Expired - Fee Related CN202786253U (en) | 2012-08-22 | 2012-08-22 | Automatic blood culture instrument |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103409316A (en) * | 2013-08-22 | 2013-11-27 | 山东鑫科生物科技股份有限公司 | Constant temperature control system for blood bacterial culture instrument |
| CN103555562A (en) * | 2013-11-01 | 2014-02-05 | 山东鑫科生物科技股份有限公司 | Blood culture instrument |
| CN108226545A (en) * | 2017-12-17 | 2018-06-29 | 索微生物技术（苏州）有限公司 | Automate blood culture method |
| CN108949561A (en) * | 2018-08-27 | 2018-12-07 | 威海正生生物科技有限公司 | Intelligent immunity cell culture oscillator |
| CN109266545A (en) * | 2018-09-29 | 2019-01-25 | 宁波新芝生物科技股份有限公司 | A kind of ultrasonic wave DNA interrupts instrument |
-
2012
- 2012-08-22 CN CN 201220417934 patent/CN202786253U/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103409316A (en) * | 2013-08-22 | 2013-11-27 | 山东鑫科生物科技股份有限公司 | Constant temperature control system for blood bacterial culture instrument |
| CN103555562A (en) * | 2013-11-01 | 2014-02-05 | 山东鑫科生物科技股份有限公司 | Blood culture instrument |
| CN108226545A (en) * | 2017-12-17 | 2018-06-29 | 索微生物技术（苏州）有限公司 | Automate blood culture method |
| CN108949561A (en) * | 2018-08-27 | 2018-12-07 | 威海正生生物科技有限公司 | Intelligent immunity cell culture oscillator |
| CN109266545A (en) * | 2018-09-29 | 2019-01-25 | 宁波新芝生物科技股份有限公司 | A kind of ultrasonic wave DNA interrupts instrument |
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| Date | Code | Title | Description |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130313 Termination date: 20200822 |
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| CF01 | Termination of patent right due to non-payment of annual fee |