CN202372445U - Fluorescence detection system - Google Patents
Fluorescence detection system Download PDFInfo
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- CN202372445U CN202372445U CN2011204432824U CN201120443282U CN202372445U CN 202372445 U CN202372445 U CN 202372445U CN 2011204432824 U CN2011204432824 U CN 2011204432824U CN 201120443282 U CN201120443282 U CN 201120443282U CN 202372445 U CN202372445 U CN 202372445U
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Abstract
The utility model provides a fluorescence detection system, which comprises a control module, a sample information acquisition module, an integrating-sphere-type optical module, a photoelectric conversion and amplification module, an analysis module and a storage module, wherein the control module is used for controlling and coordinating the work of other modules and is electrically connected with the sample information acquisition module, the integrating-sphere-type optical module, the photoelectric conversion and amplification module, the analysis module and the storage module; the sample information acquisition module is used for acquiring sample information; the integrating-sphere-type optical module is used for illuminating samples and collecting optical signals; the photoelectric conversion and amplification module is used for converting the optical signals transmitted by the integrating-sphere-type optical module into electric signals and amplifying the electric signals; the analysis module is used for analyzing the electric signals transmitted by the photoelectric conversion and amplification module; and the storage module is used for storing the sample information and detection results. The fluorescence detection system provided by the utility model has the advantages that the volume is small, the system is convenient to carry, the quantitative detection can be realized and the data is accurate.
Description
Technical field
The utility model relates to the detection system field, relates in particular to a kind of fluorescence detecting system.
Background technology
Immunolabelling technique has experienced the radio-immunity mark, and enzyme is exempted from mark, the stages such as chemiluminescent labeling.Existing technical application fluorescent technique detects immune labeled, and technology has relatively before promoted detection sensitivity greatly.Lanthanide series rare-earth elements has Stokes shift big because of it, and emission band is narrow, and the characteristics of long half time become desirable fluorescent dye.
But existing a kind of fluorescence detecting system has following deficiency:
Existing system utilizes small scale integration computer interface circuit, and it calculates and memory property can't be accomplished nowadays to the requirement of the intelligent control of biochemistry detection with data processing;
The existing system volume is big, can not satisfy numerous clinicians, inspection man author, and law enforcement agencies etc. are light, small and exquisite to detecting instrument, the basic demands such as pre-treatment of portability and release sampling;
Existing system is the application of applicable liquid sample only, can not satisfy the demands rapidly and the extremely wide quick diagnosis of application prospect for development;
Existing system utilizes xenon lamp as light source, and is bulky, and power consumption is big.
These problems have become the technical task that those skilled in the art need to be resolved hurrily.
The utility model content
The utility model relates to a kind of fluorescence detecting system; In order to the fluorescent element mark in the sample is detected; And overcome the deficiency of existing biochemistry detection system intelligent control and data-handling capacity; Volume very much not is convenient for carrying, only problem such as applicable liquid sample and large-scale production quality instability.
For achieving the above object, the fluorescence detecting system that the utility model provides comprises:
Control module is used to control the work of coordinating other modules, and said control module is electrically connected with amplification module, analysis module and memory module with sample message acquisition module, integrating sphere type optical module, photoelectricity conversion;
The sample message acquisition module is used for collected specimens information;
The integrating sphere type optical module is used for the illumination sample, collects light signal;
Photoelectricity transforms and amplification module, is used for being converted into electric signal and amplification to the light signal that the transmission of integrating sphere type optical module comes;
Analysis module is used to analyze photoelectricity and transforms and the next electric signal of amplification module transmission;
Memory module, storage sample message and testing result.
Above-mentioned sample message acquisition module comprises: scanner, stepper motor, screw mandrel and ball sliding platform; Said stepper motor is connected with screw mandrel; Said screw mandrel is connected with the ball sliding platform.
Establish a test card slot on the above-mentioned ball movable platform.
Above-mentioned memory module comprises flash disk.
Above-mentioned control module comprises inserted computer, and said inserted computer is used to control the work of sample message acquisition module, integrating sphere type optical module, photoelectricity conversion and amplification module and analysis module.
Above-mentioned memory module is arranged in the inserted computer.
Above-mentioned control module comprises pulse producer, and said pulse producer is used to control the work of sample message acquisition module, integrating sphere type optical module, photoelectricity conversion module and analysis module.
Above-mentioned each module is to be started synchronously by control module.
Above-mentioned integrating sphere type optical module comprises: integrating sphere device and excitation source.
Above-mentioned excitation source is deuterium lamp, LED light emitting diode or laser diode.Better, said excitation source is LED light emitting diode or laser diode.
Above-mentioned photoelectricity transforms with amplification module and comprises light activated element, micro current amplifier and power supply; Said light activated element receives and is converted into electric signal from the light signal of integrating sphere type optical module and with light signal, through micro current amplifier electric signal is amplified then to feed back to analysis module.
Above-mentioned light activated element is the PMT light activated element.
Above-mentioned analysis module is phase sensitivity/time resolution amplifier.
Above-mentioned fluorescence detecting system also comprises load module, and said load module is used for input command and transfers to control module.
Above-mentioned load module comprises: at least a in mouse, keyboard, optophone or the display screen.
Above-mentioned display screen is a touching display screen.
Above-mentioned fluorescence detecting system also comprises output module, and said output module is used to accept sample information and testing result and output, and said output module comprises display screen and/or printer.Preferable, said display screen is a touching display screen.
Description of drawings
Fig. 1 is the utility model fluorescence detecting system structural drawing.
Fig. 2 is for to the rare earth lanthanide nano particle being the synoptic diagram of the paper box of label the utility model detection system one embodiment of testing.
Fig. 3 is for being the bar code sample of the paper box of label with the rare earth lanthanide nano particle.
Fig. 4 is the utility model integrating sphere type optical module structural drawing.
Fig. 5 is group of the lanthanides europium element fluorescence decay time figure.
Embodiment
Below in conjunction with accompanying drawing a kind of fluorescence detecting system of the utility model is further specified.
Referring to Fig. 1,2, in the utility model one specific embodiment, said fluorescence detecting system is made up of control module, integrating sphere type optical module, photoelectricity conversion and amplification module, analysis module, load module, output module and memory module.Said control module is electrically connected with amplification module, analysis module and memory module with sample message acquisition module, integrating sphere type optical module, photoelectricity conversion.
Said control module, the work of other modules is coordinated in control, like the startup of each module, and collects from the sample sample information of sample message collection module, from the analysis result of analysis module and the pre-stored information of memory module; Control module is carried out synchronous control with the electric pulse that pulse producer produces to the startup of sample message acquisition module, integrating sphere type optical module, photoelectricity conversion and amplification module, analysis module.Control module comprises inserted computer and pulse producer in the present embodiment.The startup of said other modules of pulse producer synchro control.This inserted computer is made up of the slave computer that host computer and 51 serial CPU constitute; Owing to introduced inserted computer; And other existing systems are used small scale integration, make calculating, storage and the scalability of above-mentioned applicating example be better than other existing systems far away.
The sample message acquisition module is used for collected specimens information, comprising: scanner, stepper motor, screw mandrel and ball sliding platform.Stepper motor is connected through shaft joint with screw mandrel, and screw mandrel comprises screw rod and nut, overlaps connected nut on the screw rod, and nut is connected with the ball sliding platform through support, establishes a test card slot on the said ball sliding platform.Under stepper motor drives, the screw mandrel that is connected with stepper motor will rotatablely move, and change into the horizontal rectilinear motion of nut, and nut drives accurate ball sliding platform and also makes horizontal rectilinear motion then.Through above-mentioned annexation, under the drive of stepper motor, accurate ball sliding platform moves as horizontal linear.The sample essential information is collected by scanner.Stepper motor drives screw mandrel and accurate ball sliding platform, can realize the segmentation of same sample is repeatedly sampled, and obtains a plurality of detection by quantitative results, then averages, and the precision of its testing result is high.The sample message of this instance is based on bar code, and bar code is attached on the sample box, and said scanner is a barcode scanner.This scanner is used to scan the bar code on the tested article.Use optophone in the present embodiment.
Said integrating sphere type optical module comprises integrating sphere device and excitation source; Said excitation source is deuterium lamp, LED light emitting diode or laser diode.LED light emitting diode or laser diode have with respect to the deuterium lamp light source as light source that volume is little, power consumption is little, the simple advantage of assembly and adjustment, so preferred LED light emitting diode of the utility model or laser diode.Excitation source is the monochromatic LED light emitting diode in the present embodiment, sends the UV-irradiation specimen.
Photoelectricity transforms and amplification module, is used for being converted into electric signal and amplification to the light signal that the transmission of integrating sphere type optical module comes.Said photoelectricity transforms with amplification module and comprises light activated element, micro current amplifier and power supply; Said light activated element is the PMT light activated element.
Analysis module is used to analyze electric signal; Analysis module adopts phase sensitivity/time resolution amplifier analysis and judgement electric signal.
Memory module is used to store sample message and from the testing result of control module; In the present embodiment, memory module is integrated in inserted computer, in order to increase storage volume, also cooperates a flash disk to use.Certainly, also can take other modes, be arranged in the inserted computer or can adopt inserted computer to combine flash disk simultaneously like memory module, so that obtain bigger storage space.
This system also comprises load module, is used for input command and transfers to control module; Said load module comprises mouse, keyboard, optophone and touching display screen.
This system also comprises output module, is used to accept sampling, testing result and the output from control module.Said output module comprises display screen and printer.
In another embodiment, the utility model load module and output module are one, i.e. a touching display screen.Said touching display screen promptly can input command and information, can export testing result etc. again.All the other modules are with last embodiment.
Those skilled in the art can make various changes according to the disclosure of the utility model, like load module, and at least a in mouse, keyboard, optophone or the display screen.Output module then is at least a in display screen, the printer.
The utility model has the advantages that:
1. the described control module of the utility model adopts inserted computer, can connect flash disk as exterior storage, and keyboard, mouse, printer, optophone etc. are as input-output device.Because the system of the utility model has introduced inserted computer, and other existing systems are used small scale integrations, make calculating, storage and the scalability of system of the utility model be better than other existing systems far away.
2. light source is selected flexibly in the described integrating sphere type optical module of the utility model; Can be xenon lamp or LED or laser diode, having overcome other existing systems can only be with xenon lamp as light source, thereby has avoided bulky; Power consumption is big; Light, machine work processing capacity are big, dress, transfer complex process, for the extensive industrialization of product brings huge shortcomings such as labile factor.
3. the utility model adopts electronically controlled pulse work to solve the synchronous synergetic work problem of multimode.Make system architecture more reasonable with respect to existing other system, volume is littler, and power consumption is lower.
4. the utility model not only can be sampled to paper box, also can sample to test strips, has remedied the deficiency that other existing systems only can the applicable liquid sample.
5. system's area occupied of using the utility model has only 20 centimetres to multiply by 20 centimetres.Compare with other existing systems and to be more convenient for carrying, to be convenient to disposing.
The utility model in actual use, can be applicable to detection by quantitative with fluorescence labeling particularly the rare earth lanthanide nano particle be the solid-phase immunity crossing current chromatographic test paper box of label, referring to Fig. 2.Paper box comprises the separation of whole blood pad that is used for separating red corpuscle; Being specifically designed to fixing and discharging the rare earth lanthanide nano particle is the bond releasing cushion of mark; Be used for absorbing the absorption pad of liquid, form, have the reacting pad of detection line and nature controlling line by nitrocellulose filter or glass fibre membrane in downstream.Post bar code (like Fig. 3) at the back side of paper box, bar code is corresponding with the manufacturing parameter (like parameters such as dates of manufacture) of test item, calibration curve correction factor, paper box.
Put into the test card slot on the accurate ball sliding platform to carton to be tested during detection by quantitative.For detecting, the reagent of each lot number all can have information such as manufacturing parameter such as the date of manufacture of relevant detection project, calibration curve correction factor, paper box.These information are set in the photoelectricity scale-of-two bar code in advance.
When detection begins to be performed; Detect and require to be submitted to the detection system in the foregoing description; After sample message acquisition module and control module read the bar code at the paper box back side through optophone, can contrast whether this batch targeted message is arranged in the memory module.Require not exist if detect, the system prompt user changes correct paper box into and carries out detection by quantitative.If detect to require exist, paper box can be sent into instrument internal by the scanning platform of sample message acquisition module, under the driving of stepper motor, spurs accurate ball sliding platform by screw mandrel and does one dimension and move horizontally, and begins to detect.
When detection was carried out, the application of LEDs light source was through integrating sphere irradiation paper box surface in integrating sphere type optical module (like Fig. 4).The carton that contains rare earth lanthanide can excite by stimulated luminescence, sends the emitting fluorescence of hysteresis, promptly launches light.
Emitting fluorescence is connected the photoelectricity conversion of integrating sphere to be collected with PMT (light activated element) probe of the receiving orifice of amplification module continuously, and is converted into little electric signal.Little electric signal is amplified by micro current amplifier.
The phase sensitivity of analysis module/time resolution amplifier is accepted to transform the electric signal with the amplification module feedback by photoelectricity, the power of analysis of fluorescence, and result transmission to control module.
For same position, with an excitation light irradiation, because the fluorescence decay time of rare earth lanthanide has 1000 microseconds above (like Fig. 5), the window time is long.At 400-800 microsecond place is preferable measurement window.Pulse producer control integrating sphere type optical module, photoelectricity conversion and amplification module and the analysis module of control module repeatedly detect sample.Control module is accepted the repeatedly analysis result from analysis module, transfers the correlation data that prestores in the memory module through inserted computer, draws the content results of rare earth lanthanide.Therefore, at same position, repeatedly measuring under the same excitation light irradiation can improve the precision of measurement greatly.
The pulse producer of control module sends signal to the stepper motor of sample message acquisition module, under step motor drive, is moved horizontally as one dimension by screw mandrel pulling sample.Once more sample is detected by the collaborative integrating sphere type optical module of control module, photoelectricity conversion and amplification module and analysis module simultaneously.So constantly repeat above step, thereby realized the diverse location of same sample is carried out repeated detection.So through to same sample, the repeated detection of diverse location also can improve the precision of measurement.
After sample detection finishes, the average of the manufacturing parameter of test item, paper box, the testing results such as rare earth lanthanide content repeatedly measured and distribution pattern will be shown in touching-type monitor, and simultaneously by printer output.
Above-mentioned applicating example adopts electronically controlled pulse work to solve the synchronous synergetic work problem of multimode.Make system architecture more reasonable with respect to existing other system, volume is littler, and power consumption is lower.
Above-mentioned applicating example area occupied has only 20 centimetres to multiply by 20 centimetres.Compare with other existing systems and to be more convenient for carrying, to be convenient to disposing.
Scanner in the utility model information acquisition module all is connected with control module with stepper motor.
In sum; The calculating of the said fluorescence detecting system of the utility model and memory property are good, the strong volume of extendability is little, light source is selected flexibly, have solved the calculating of existing other fluorescence detecting systems and storage property is not enough, volume is big, be only applicable to fluid sample, problem that power consumption is big has great market outlook.
All documents in that the utility model is mentioned are all quoted as a reference in this application, are just quoted such as a reference separately as each piece document.Should be understood that in addition after having read the above-mentioned teachings of the utility model, those skilled in the art can do various changes or modification to the utility model, these equivalent form of values fall within the application's appended claims institute restricted portion equally.
Claims (10)
1. a fluorescence detecting system is characterized in that, said fluorescence detecting system comprises:
Control module is used to control the work of coordinating other modules, and said control module is electrically connected with amplification module, analysis module and memory module with sample message acquisition module, integrating sphere type optical module, photoelectricity conversion;
The sample message acquisition module is used for collected specimens information;
The integrating sphere type optical module is used for the illumination sample, collects light signal;
Photoelectricity transforms and amplification module, is used for being converted into electric signal and amplification to the light signal that the transmission of integrating sphere type optical module comes;
Analysis module is used to analyze photoelectricity and transforms and the next electric signal of amplification module transmission;
Memory module, storage sample message and testing result.
2. fluorescence detecting system according to claim 1 is characterized in that said sample message acquisition module comprises: scanner, stepper motor, screw mandrel and ball sliding platform; Said stepper motor is connected with screw mandrel; Said screw mandrel is connected with the ball sliding platform.
3. fluorescence detecting system according to claim 1 is characterized in that said memory module comprises flash disk.
4. fluorescence detecting system according to claim 1; It is characterized in that; Said control module comprises inserted computer, and said inserted computer is used to control the work of sample message acquisition module, integrating sphere type optical module, photoelectricity conversion and amplification module and analysis module.
5. like the said fluorescence detecting system of claim 4, it is characterized in that said memory module is arranged in the inserted computer.
6. fluorescence detecting system according to claim 1 is characterized in that said control module comprises pulse producer, and said pulse producer is used to control the work of sample message acquisition module, integrating sphere type optical module, photoelectricity conversion module and analysis module.
7. like the said fluorescence detecting system of claim 4, it is characterized in that said each module is to be started synchronously by control module.
8. like the said fluorescence detecting system of claim 6, it is characterized in that said each module is to be started synchronously by control module.
9. fluorescence detecting system according to claim 1 is characterized in that said integrating sphere type optical module comprises: integrating sphere device and excitation source.
10. like the said fluorescence detecting system of claim 8, it is characterized in that said excitation source is deuterium lamp or LED light emitting diode or laser diode.
11. like the said fluorescence detecting system of the arbitrary claim of claim 1-10; It is characterized in that; Said photoelectricity transforms with amplification module and comprises light activated element, micro current amplifier and power supply, and said light activated element receives the light signal from the integrating sphere type optical module, and light signal is converted into electric signal; Through micro current amplifier electric signal is amplified then, feed back to analysis module.
12. transform and amplification module like the said photoelectricity of claim 11, it is characterized in that said light activated element is the PMT light activated element.
13., it is characterized in that said analysis module is phase sensitivity/time resolution amplifier like claim 1-10 or the said fluorescence detecting system of 12 arbitrary claims.
14., it is characterized in that said analysis module is phase sensitivity/time resolution amplifier like the said fluorescence detecting system of claim 11.
15. like claim 1-10 or the said fluorescence detecting system of 12 arbitrary claims, it is characterized in that said fluorescence detecting system also comprises load module, said load module is used for input command and transfers to control module.
16., it is characterized in that said fluorescence detecting system also comprises load module like the said fluorescence detecting system of claim 11, said load module is used for input command and transfers to control module.
17., it is characterized in that said load module comprises like the said fluorescence detecting system of claim 15: at least a in mouse, keyboard, optophone or the display screen.
18., it is characterized in that said load module comprises like the said fluorescence detecting system of claim 16: at least a in mouse, keyboard, optophone or the display screen.
19., it is characterized in that said display screen is a touching display screen like claim 17 or 18 said fluorescence detecting systems.
20. like claim 1-10,12,14, the said fluorescence detecting system of the arbitrary claim of 16-18; It is characterized in that; Said fluorescence detecting system also comprises output module; Said output module is used to accept sample information and testing result and output, and said output module comprises display screen and/or printer.
21., it is characterized in that said fluorescence detecting system also comprises output module like the said fluorescence detecting system of claim 11, said output module is used to accept sample information and testing result and output, said output module comprises display screen and/or printer.
22., it is characterized in that said fluorescence detecting system also comprises output module like the said fluorescence detecting system of claim 13, said output module is used to accept sample information and testing result and output, said output module comprises display screen and/or printer.
23., it is characterized in that said fluorescence detecting system also comprises output module like the said fluorescence detecting system of claim 15, said output module is used to accept sample information and testing result and output, said output module comprises display screen and/or printer.
24., it is characterized in that said fluorescence detecting system also comprises output module like the said fluorescence detecting system of claim 19, said output module is used to accept sample information and testing result and output, said output module comprises display screen and/or printer.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011204432824U CN202372445U (en) | 2011-11-10 | 2011-11-10 | Fluorescence detection system |
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| CN2011204432824U CN202372445U (en) | 2011-11-10 | 2011-11-10 | Fluorescence detection system |
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| CN202372445U true CN202372445U (en) | 2012-08-08 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103063625A (en) * | 2012-12-07 | 2013-04-24 | 深圳国际旅行卫生保健中心 | Rat-track detector |
| CN103454259A (en) * | 2013-09-05 | 2013-12-18 | 凌中鑫 | Biosensor based on up-converting phosphor technology |
| CN105527587A (en) * | 2015-12-30 | 2016-04-27 | 常州数控技术研究所 | Lamp performance detecting device |
| CN110638426A (en) * | 2019-07-22 | 2020-01-03 | 邱海林 | Laser scanning living body fluorescence imaging signal acquisition device |
-
2011
- 2011-11-10 CN CN2011204432824U patent/CN202372445U/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103063625A (en) * | 2012-12-07 | 2013-04-24 | 深圳国际旅行卫生保健中心 | Rat-track detector |
| CN103063625B (en) * | 2012-12-07 | 2015-03-04 | 深圳国际旅行卫生保健中心 | Rat-track detector |
| CN103454259A (en) * | 2013-09-05 | 2013-12-18 | 凌中鑫 | Biosensor based on up-converting phosphor technology |
| CN105527587A (en) * | 2015-12-30 | 2016-04-27 | 常州数控技术研究所 | Lamp performance detecting device |
| CN105527587B (en) * | 2015-12-30 | 2019-01-29 | 常州数控技术研究所 | Lamp performance detection device |
| CN110638426A (en) * | 2019-07-22 | 2020-01-03 | 邱海林 | Laser scanning living body fluorescence imaging signal acquisition device |
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| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120808 Termination date: 20171110 |
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| CF01 | Termination of patent right due to non-payment of annual fee |