CN201159737Y - Liquid sample collection and detection apparatus - Google Patents
Liquid sample collection and detection apparatus Download PDFInfo
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- CN201159737Y CN201159737Y CNU2007203031011U CN200720303101U CN201159737Y CN 201159737 Y CN201159737 Y CN 201159737Y CN U2007203031011 U CNU2007203031011 U CN U2007203031011U CN 200720303101 U CN200720303101 U CN 200720303101U CN 201159737 Y CN201159737 Y CN 201159737Y
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Abstract
The utility model provides a liquid sample collecting and detecting device; the detecting device comprises a collecting cavity, a detecting cavity and a transferring cavity connected with the collecting cavity and the detecting cavity; the transferring cavity is respectively connected with the collecting cavity and the detecting cavity through at least two through holes; wherein, both ends of the opening of at least a through hole are positioned at both sides of the highest position or the lowest position of the transferring cavity. The liquid sample collecting and detecting device solves the problems that the flow blockage of the liquid sample or the insufficient quantity of the sample for detection caused by the bubble generated by the fast liquid flow velocity found in the detecting device in the prior art through changing the position of the through hole in the liquid sample detecting device.
Description
Technical field
The utility model relates to a kind of liquid sample collection and detection device, especially a kind of liquid sample collection and detection device that detects illegal drug.
Background technology
At present, it is more and more easier that general public obtains violated medicine, and the use of the medicine of therefore violating a ban is also more and more.For the safety that guarantees working environment and the fair competition of physical culture, the employee need detect in enterprise, unit and sports organization, athletic body fluid is for example urinated, and whether has used violated medicine to understand employee and sportsman.What therefore Humoral sample Detection and Collect device was used is more and more, and need be operated by the layman in common occasion.Use traditional liquid sample collection and detection device, exist amount of liquid can not be accurately quantitatively to produce, the requirement in the time of can not satisfying the accurate quantification of liquid sample or micromanipulation the influential situation of testing result.
U.S. Pat 6372515 discloses a sample collection pick-up unit, and this device comprises a test card of collecting the urine sample cup of urine sample and having many detector bars, and detector bar is used for detecting urine sample.During use, test card is inserted the urine sample cup, allow detector bar contact with urine sample, detection can be finished in a few minutes like this.After detection was finished, the urine sample in the urine sample cup was the material contamination in the detected reagent strip, can not finish the secondary affirmation checking that the professional carries out.
ZL 200420107950.6 discloses a body fluid sample pick-up unit, and by the piston hole of the end opening that glass body bottom has is set, and the through hole that communicates with the cup chamber and the through hole that communicates with slot carry out the transfer of liquid sample, realizes detection by quantitative.In the disclosed utility model of this piece of writing, comprise first through hole and second through hole, but causing the ring groove in the piston hole easily in the reagent operating process, this mode is detained bubble and sample, cause the error of detection by quantitative to cause that the result is inaccurate.
Summary of the invention
In order to solve these deficiencies of prior art, the utility model provides a kind of liquid sample collection and detection device, can make that liquid sample is smooth and easy must transfer to the another one chamber from a chamber, and can make detection by quantitative better accurately.
The utility model solves the technical scheme that its technical matters adopts:
The utility model provides a kind of liquid sample collection and detection device, this pick-up unit comprises collecting chamber and test chamber, and the transfer chamber that connects collecting chamber and test chamber, transfer chamber links to each other with test chamber with collecting chamber respectively by at least two through holes, wherein the opening two ends of at least one through hole be positioned at transfer chamber the extreme higher position both sides or be positioned at the both sides of transfer chamber extreme lower position.
In one embodiment, opening one end of through hole drops on the transverse axis (X-axis).
Preferably, the opening two ends of through hole are spent less than 180 greater than 90 degree with the angle that the longitudinal axis that passes through transfer chamber forms.
More preferred, the opening two ends of through hole are 100 degree with the angle that the longitudinal axis by transfer chamber forms.
In another embodiment, the opening of through hole departs from transverse axis (X-axis) and vertical pivot (Z axle).
Preferably, the opening two ends of through hole are 90 degree with the angle that the longitudinal axis (Y-axis) that passes transfer chamber forms.
In one embodiment, transfer chamber comprises two through holes, and the via openings two ends that communicate with collecting chamber are positioned at the both sides of the extreme higher position of transfer chamber, and the opening two ends of the through hole that communicates with test chamber are positioned at the both sides of the extreme lower position of transfer chamber.
Preferably mode is, what communicate with collecting chamber is last through hole, and what communicate with test chamber is lower through-hole, and last through hole and lower through-hole are not in same plane.
Another preferred embodiment in, comprise on the transfer chamber that two are gone up through holes and two lower through-holes.
More preferred, the opening two ends of through hole are spent less than 90 with the angle that the longitudinal axis (Y-axis) that passes transfer chamber forms.
In a more preferred mode, on the transfer chamber two go up everybody 45 degree of angle that through hole and two lower through-holes and the longitudinal axis by transfer chamber form.
In another embodiment, transfer chamber is a piston hole, and xsect is circular, and last through hole and lower through-hole are circular arc.
More than preferred, comprise the piston that can slipper seal cooperates in the piston hole.
More preferred, piston nose has ring groove, when communicating with collecting chamber by last through hole, isolates with test chamber; When communicating with test chamber, isolate with collecting chamber by lower through-hole.
The effect that the utility model is useful is: thus the utility model by the lead to the hole site that changes liquid sample detection device inside solve in common pick-up unit, exist because the excessive bubble that produces of flow rate of liquid causes the mobile not enough problem of amount of blocking up and being used to detect sample of liquid sample, so that reach the purpose of accurate quantification liquid sample.
Description of drawings
Fig. 1 is the explosive decomposition figure of a certain embodiment of the utility model;
Fig. 2 is the stereographic map of Fig. 1 utility model;
Fig. 3 is the sectional stereogram of the transfer chamber in Fig. 1 utility model, X, and Y, three arrows of Z are represented X-axis (transverse axis) respectively, Y-axis (longitudinal axis) and Z axle (vertical pivot);
Fig. 4 is the sectional axonometric drawing of Fig. 1 utility model, can see the section of going up through hole;
Fig. 5 is another embodiment of through hole on the utility model;
Fig. 6 is another embodiment of through hole on the utility model;
Fig. 7 is another embodiment of through hole on the utility model;
Fig. 8 is another sectional axonometric drawing of the present utility model, can see the section of lower through-hole;
Fig. 9 is another embodiment of the utility model lower through-hole;
Figure 10 is another embodiment of the utility model lower through-hole;
Figure 11 is another embodiment of the utility model lower through-hole;
Figure 12 uses preceding diagrammatic cross-section for the utility model;
Diagrammatic cross-section after when Figure 13 is the utility model.
Description of reference numerals: bowl cover 1; Cup body 2, rim of a cup 20, rim of a cup screw thread 201, collecting chamber 21, transfer chamber 22, piston 23, rubber band 24, piston hole opening 25, ring groove 26, last through hole 27, lower through-hole 28, piston hole 29; Cup 3, thieving paper 31, test chamber 32; O-ring seal 4; Test card 5, bar 52 is mingled in testing result viewing area 51, plate 53; Bolt 6; The extreme higher position 7 of transfer chamber; The extreme lower position 8 of transfer chamber.
Embodiment
Structure or these employed technical terms to the liquid sample collection and detection device is described further below.
Detect
Detect the expression chemical examination or test a kind of material or whether material exists, such as, but be not limited to this, the metabolin of chemical substance, organic compound, mineral compound, metabolism product, medicine or drug metabolite, organic organization or organic organization, nucleic acid, protein or polymkeric substance.In addition, detect the quantity of expression test substances or material.Furtherly, immune detection, chemical detection, enzyme detection etc. are also represented in chemical examination.
Sample
The sample of the utility model indication refers to that those can be used for detecting, chemically examining or diagnose the material that whether has analyte of interest matter.Sample can be that for example, liquid sample, liquid sample can comprise blood, blood plasma, serum, urine, saliva and various juice, can also comprise that solid sample and semi-solid samples are through anticipating the liquid solution that the back forms.The sample of collecting can be used for methods such as immune detection, chemical detection, enzyme detection and detect whether there is analyte.
Axis
Axis according to space three-dimensional, be example with transfer chamber 22 in the utility model, with the D structure of transfer chamber 22 as a steric configuration, cross fixed point three mutually perpendicular number axis are arranged, they all are initial point with the fixed point and generally have identical long measure. these three axles are called X-axis (transverse axis), Y-axis (longitudinal axis), Z axle (vertical pivot) respectively, the general designation coordinate axis.Usually X-axis and Y-axis are configured on the surface level, the Z axle then is a pedal line.The term that uses in the utility model, X-axis (transverse axis), Y-axis (longitudinal axis) and Z axle (vertical pivot) they are that those skilled in the art are commonly used and accessible.The transverse axis and the longitudinal axis constitute the plane and rotate the whole cavity that has formed transfer chamber 22 around vertical pivot.
Pick-up unit
Pick-up unit is to be used to collect liquid, such as urine etc., and analyzes the situation of its contained analyte (as drugs and metabolin thereof).Pick-up unit can comprise that one is used to collect the collecting chamber 21 of liquid sample, contains the test chamber 32 of test card 5 and liquid sample is transferred to the transfer chamber 22 of test chamber 32 from collecting chamber 21.Pick-up unit can be made by multiple difformity and different materials, for example the plastics of all size.
The cavity of collecting chamber 21 can adopt Any shape, such as cylindrical, and syringe-like shape, chimney, perhaps other can be used for any form of storaging liquid.Collecting chamber 21 can be by cup body 2, and rim of a cup 20 and bowl cover 1 are formed.Rim of a cup 20 and bowl cover 1 can guarantee that liquid holds and do not leak out by sealing in cup body 2.The seal form of rim of a cup 20 and bowl cover 1 can have multiple, such as rim of a cup 20 and bowl cover 1 screw thread 20 of working in coordination can be arranged, and reaches the effect of sealing by the mode of rotation.Better, can also in bowl cover 1, be provided with O-ring seal 4, the effect on the cup edge by O-ring seal 4 and rim of a cup 20 is played sealing function to device.
The shape of piston hole 22 and size are unrestricted, and the cross section of piston hole 22 can be circular, also can be oval-shaped, can also be rhombus, or even foursquare or other are regular or irregular shape.The piston hole 22 of above-mentioned shape has also determined the shape of built-in piston 23 wherein.Wherein, circular piston hole 22 comparative optimizations help piston 23 and can must promote smoothly therein.Can comprise piston 23 in the piston hole 22, piston 23 can cooperate in slipper seal.The front end of piston 23 can have ring groove 26, and when communicating with collecting chamber 21 by last through hole 27, ring groove 26 is isolated with test chamber 32; When communicating with test chamber 32 by lower through-hole 28, ring groove 26 is isolated with collecting chamber 21.Such structure can make sample can directly not circulate in three cavitys, can guarantee that the sample in the collecting chamber 21 enters after the test chamber 32, can not be back to once again in the collecting chamber 21, and is relatively good for secondary detection and sample reservation effect.In addition, piston 23 can be pushed slip, also can be to rotate to slide.The shift in position of piston 23 can be unidirectional, also can back and forth movement.The piston 23 of preferred unidirectional slip, such piston 23 is from primary importance (collecting chamber 21 and transfer chamber 22 communicate) to the second place (transfer chamber 22 and test chamber 32 communicate) time, and is just static, and sample can not be back in the collecting chamber 21 more yet.This mode is simple to operate, only piston 23 need be pushed to assigned address and get final product.
Through hole
Through hole comprises through hole 27 and lower through-hole 28.Last through hole 27 is meant the zone that communicates with collecting chamber 21, and lower through-hole 28 is meant the zone that communicates with test chamber 32.Last through hole 27 and lower through-hole 28 can be each one, also can be each two, or even how identical number or different number, are 1 such as the number of last through hole 27, and the number of lower through-hole 28 is 2; The number that perhaps goes up through hole 27 is 2, and the number of lower through-hole 28 is 1; The number of last through hole 27 is 1, and the number of lower through-hole 28 is 3; The number that perhaps goes up through hole 27 is 3, and the number of lower through-hole 28 is one; The number that perhaps goes up through hole 27 is 2, and the number of lower through-hole 28 is 3; The number that perhaps goes up through hole 27 is 3, and the number of lower through-hole 28 is 2; The perhaps collocation mode that the technician knows in the field.The shape of last through hole 27 can be banded circular arc, also can be the circular arc of undaform, can also be other indefinite shapes.Last through hole 27 and lower through-hole 28 are not in same plane, last through hole 27 can be positioned at any position of transfer chamber 22, and lower through-hole 28 also can be positioned at any position of transfer chamber 22, and is preferred, last through hole 27 is positioned at the middle part of transfer chamber 22, and lower through-hole 28 is positioned at the end of transfer chamber 22.Like this, in transfer chamber 22, certain space can be left, quantitative experiment can be carried out.Through hole can be directly and collecting chamber 21 or test chamber 32 communicate, also can make it to be in the liquid communication state by indirect mode.Through hole can be on any position of transfer chamber 22, preferably, the opening two ends of through hole are positioned at the extreme higher position 7 of transfer chamber 22 or the both sides of extreme lower position 8, on coordinate axis, extreme higher position 7 and extreme lower position 8 are positioned on the Z axle, are the intersections that Z axle and transfer chamber 22 are pushed up up and down.The opening two ends of through hole 27 are positioned at the both sides of extreme higher position 7 or extreme lower position 8, be meant that through hole covers the extreme higher position 7 and the extreme lower position 8 of transfer chamber 22 fully, that is to say, liquid sample can flow into the transfer chamber 22 from collecting chamber 21 by the extreme higher position 7 of through hole from transfer chamber 22, also can flow in the test chamber 32 from transfer chamber 22 by the extreme lower position 8 of transfer chamber 22.The position mode of this through hole helps sample and enters transfer chamber 22 swimmingly, and smooth and easyly must flow into test chamber 32 from transfer chamber 22.The position of last through hole 27 can be in any position between transfer chamber 22 and the collecting chamber 21, and the position of lower through-hole 28 can be in any position between transfer chamber 22 and the test chamber 32, and their effects are can carry out liquid communication respectively to shift.Preferably, the opening two ends of last through hole 27 are positioned at the extreme higher position 7 of transfer chamber 22, and the opening two ends of lower through-hole 28 are positioned at the extreme lower position 8 of transfer chamber 22.When last through hole 27 covers the extreme higher position 7 of transfer chamber 22, because the action of gravity of liquid is greater than the air pressure in the transfer chamber 22, liquid sample can be very smooth and easy enter transfer chamber 22, bubble is trapped in the transfer chamber 22 causes liquid sample can not enter the not enough situation of liquid sample in transfer chamber 22 and the transfer chamber 22.In like manner, the position of lower through-hole 28 is positioned at the extreme lower position 8 of transfer chamber 22, and the action of gravity of liquid that is arranged in transfer chamber 22 makes liquid smooth and easyly must flow into test chamber 32 greater than the air pressure of test chamber 32, finishes testing process.
The opening of through hole is positioned on transfer chamber 22 walls, and the position at opening two ends can be on wall.Opening can have two, and the position of opening can be dropped on transverse axis and the vertical pivot, also can depart from transverse axis and vertical pivot.One end opening of last through hole 27 can be positioned at piston hole and collecting chamber 21 inner chamber intersections (X-axis), and another opening drops on the position that piston hole top is projected on collecting chamber 21 inwalls (Z axle).Two openings in the two ends of last through hole 27 can all not drop on X-axis and the Z axle yet.The size of through hole can be via openings two ends and arbitrarily angled, the such angle that the longitudinal axis that passes through transfer chamber 22 centers forms, and can be 10 degree, 20 degree, and 30 degree, 40 spend, 50 degree, 60 degree, 70 degree, 80 degree, 90 spend, 100 degree, 120 degree etc.Preferably, the opening two ends of through hole are spent less than 180 greater than 90 degree with the angle that the longitudinal axis that passes through transfer chamber 22 forms.Preferred, the opening two ends of through hole are 100 degree with the angle that central shaft by transfer chamber 22 forms.Through hole can also be less than a plurality of openings of 90 degree, is distributed in each position on transfer chamber 22 walls, can be in the same plane, and also can be not at grade.
Concrete must saying, above through hole 27 is an example, and is preferred, the angle that the opening two ends of last through hole 27 and the longitudinal axis by transfer chamber 22 form can be spent and less than 180 angles of spending greater than 90.Such angle can be 91 degree, 92 degree, 95 degree, 100 degree, 110 degree, 120 degree, 130 degree, 140 degree, 150 degree, 160 degree, 170 degree, 175 degree, 179 degree etc.When the angle that forms with the longitudinal axis by transfer chamber 22 at the opening two ends of last through hole 27 is too small, owing to collect in the sample process, the flow velocity of liquid sample is too fast, make the gas in the dead slot of storaging liquid in the transfer chamber 22 have little time to drain fully, and be trapped in the dead slot, concerning needs detect the more accurate pick-up unit of sample size, be extremely disadvantageous in the time of especially a small amount of or trace detection.The angle that forms with the longitudinal axis by transfer chamber 22 when the opening two ends that through hole 27 is set becomes big, and when just enlarging the size that goes up through hole 27, because opening becomes big, the gas in the dead slot can better smooth and easy must the discharge.In addition, even be detained portion gas in the dead slot, so that produce bubble, such bubble also is easy to be discharged from.This be because, less and when having only one to go up through hole 27 when the aperture efficiency of last through hole 27, between the highest opening of the top of transfer chamber 22 and last through hole 27 certain distance is arranged, because the fluid-tight of top liquid, the bubble that is trapped between through hole 27 the highest openings and transfer chamber 22 tops can't discharge.And the angle that the opening two ends that through hole 27 is set and the longitudinal axis by transfer chamber 22 form greater than 90 degree less than the improvement of 180 degree, make transfer chamber 22 tops fully and the liquid in the collecting chamber 21 contact, thereby liquid sample can fill up the dead slot in the transfer chamber 22 and can not be detained bubble.The both ends open of lower through-hole 28 also can be greater than 90 degree less than 180 degree with the angle liquid that forms by transfer chamber 22 longitudinal axis, and such angle also can be 91 degree, 92 degree, 95 degree, 100 degree, 110 degree, 120 degree, 130 degree, 140 degree, 150 degree, 160 degree, 170 degree, 175 degree, 179 degree etc.Help liquid sample like this and all enter in the test chamber 32, can not cause liquid sample to remain in the transfer chamber 22 and make the problem that detects the sample size deficiency.
Preferably, the opening two ends of last through hole 27 can be 90 angles of spending with the angle that the longitudinal axis by transfer chamber 22 forms, at this moment, the opening of last through hole 27 departs from its transverse axis (X-axis) and vertical pivot (Z axle), that is to say, from the cross section, the two ends of opening, neither drop on transfer chamber 22 and collecting chamber 21 intersections, also do not drop on the extreme higher position 7 of transfer chamber 22.Equally, the opening two ends of lower through-hole 28 also can be 90 angles of spending with the angle that the longitudinal axis by transfer chamber 22 forms, its opening departs from transverse axis and vertical pivot, the position that on the cross section, shows, then show as and neither drop on transfer chamber 22 and test chamber 32 intersections, also do not drop on the extreme lower position 8 of transfer chamber 22.In this way, can effectively must avoid because the extreme higher position 7 and the extreme lower position 8 of transfer chamber 22 are closed the bubble trapping phenomena that face causes, liquid sample can smooth and easyly must enter transfer chamber 22 from collecting chamber 21, enters test chamber 32 subsequently.
The opening two ends of last through hole 27 can be spent less than 90 with the angle that the longitudinal axis by transfer chamber 22 forms.The opening two ends of last through hole 27 with form by transfer chamber 22 longitudinal axis angle, can be 5 degree, 10 degree, 20 degree, 30 degree, 40 degree, 45 degree, 50 degree, 60 degree, 70 degree, 80 degree.Preferred miter angle, through hole 27 is positioned at the extreme higher position 7 of transfer chamber 22 on one of them, and through hole 27 can be positioned at any position of transfer chamber 22 inwalls on another, on the interface wall that is positioned at transfer chamber 22 and collecting chamber 21.Preferably, pick-up unit comprises that going up 27, two of through holes for 2 upward has between the through hole 27 at interval, and the maximum distance between each through hole surpasses 90 degree.By the mode of a plurality of through holes is set on transfer chamber 22, solved in the pattern detection process because the problem that the bubble in the transfer chamber is detained.Equally, the mode of lower through-hole 28 is similar to last through hole 27, and sample can must flow into test chamber 32 smoothly in transfer chamber 22.
Analyte
Can analyze any analyte with apparatus and method of the present utility model.The example of the analyte of the enough apparatus and method stable detection of the present utility model of energy comprises (but not only comprising) human chorionic gonadotrophin (hCG), lutropin (LH), ovarian stimulation element (FSH), hepatitis C virus (HCV), hepatitis B (HBV), hepatitis B surface antigen, the medicine of AIDS virus and any abuse.Analyte can detect in any liquid or liquefied sample, urine for example, saliva, saliva, blood, blood plasma, perhaps serum.The example of other analyte also has the acid of flesh ammonia acid anhydride, cholerythrin, nitrite, protein (nonspecific), blood, leucocyte, blood sugar, heavy metal and toxin, the bacterium composition is (for example, special protein and the sugar of the bacterium of particular type, Escherichia coli O 157: H7 for example, staphylococcus aureus, salmonella, C.perfringens, campylobacter, listeria monocytogenes, enteritis vibrios, perhaps cured shape bacillus).Any other analyte of suitable lateral flow assay form can detect with this device.
Analyte can also be some haptens materials, and these haptens comprise drugs (as drug abuse)." drug abuse " (DOA) is meant that the non-medical destination uses medicine (playing the paralysis nerve usually).Abuse these medicines and can cause body ﹠ mind to suffer damage, produce dependence, habit-forming and/or dead.The example of drug abuse comprises cocaine; Amphetamine (for example, black beauty, white amphetamine tablet, dextroamphetamine, dexie, Beans); Crystal methamphetamine (crank, meth, crystal, speed); Barbiturate (as Valium, RochePharmaceuticals, Nutley, New Jersey); Sedative (paramedicines of promptly sleeping); Lysergic acid diethylamide (LSD); Inhibitor (downers, goofballs, barbs, blue devils, yellow jackets, methaqualone); The anti-antidepressant of tricyclic antidepressants (TCA, i.e. imipramine, amitriptyline and doxepin); Hog (PCP); Tetrahydrocannabinol (THC, pot, dope, hash, weed, etc.); Opiate (being morphine, opium, codeine, heroin, the hydroxyl dihydrocodeinone); Anxiolytic and hypnotic sedative agent, anxiolytic is that a class is mainly used in anxiety reduction, nervous, frightened, set the mind at rest, have the medicine of hypnosis sedation concurrently, comprise Benzodiazepines (benzodiazepines, BZ), atypia BZ class, merge phenodiazine NB23C class, the tall and erect class of benzene nitrogen, the part class of BZ acceptor, open loop BZ class, diphenylmethane derivatives, the piperazine carboxylic acid salt, the piperidine carboxylic acid salt, Kui azoles quinoline ketone, thiazine and thiazole, other heterocyclic, imidazole type calmness/anodyne, propanediol derivative-carbamates, fatty compound, anthracene derivative etc.Use this device also can be used to detect and belong to medical usage but the detection of overdose easily, as tricyclic antidepressant (imipramine or analog) and Paracetamol etc.Can resolve into different small-molecule substances after these medicines are absorbed by the body, these small-molecule substances are present in the body fluid such as blood, urine, saliva, sweat or there is above-mentioned small-molecule substance in part body fluid.
Below in conjunction with concrete accompanying drawing examples of implementation of the present utility model are described in detail.These specific embodiment only are limited the enumerating under the utility model spirit, do not get rid of one of ordinary skill in the art prior art and the utility model in conjunction with and other specific embodiments of producing.
As depicted in figs. 1 and 2, this liquid sample collection and detection device comprises collecting chamber 21 and test chamber 32, and liquid in the collecting chamber 21 can be transferred to the piston hole (transfer chamber) 22 of test chamber 32.Collecting chamber 21 comprises glass body 2, and cup body 2 tops are provided with rim of a cup 20, and inside has a glass chamber; Rim of a cup 20 is provided with bowl cover 1, and the xsect of this bowl cover 1, rim of a cup 20 is circle, and bowl cover 1 is connected with rim of a cup 20 screw threads 201.Test chamber 32 bottoms are provided with cup 3, have slot on the cup 3, are inserted with the test card 5 of tape test bar in the slot.Fig. 3 for another example, Fig. 4, Fig. 5, shown in Fig. 8 and Fig. 9, piston hole 22 communicates with the cup chamber by the last through hole 27 of its upper wall, and communicates with slot by the lower through-hole 28 of lower wall, cup 3 has a translot that communicates with slot over against lower through-hole 28 places, and lower through-hole 28 communicates with slot by this translot.Piston hole 22 built-in pistons 23, this piston 23 is in slipper seal with piston hole and cooperates, and these piston 23 front ends have ring groove 26.Piston 23 is at the primary importance place, and ring groove 26 communicates with the cup chamber by last through hole 27, but isolates with test board 5, becomes the cavity that can hold the liquid sample that stays in glass chamber, is with rubber band 24 on the piston 23.At second place place, ring groove 26 is isolated with the cup chamber but is communicated with slot by lower through-hole 28, and last through hole 27 and lower through-hole 28 can not communicate with ring groove 26 simultaneously.Last through hole 27 is positioned at the extreme higher position 7 of piston hole, and opening one end is positioned at the intersection of piston hole 22 and cup body 2 inwalls, and the other end drops on the position that transfer chamber 22 is projected on glass body 2 inwalls.Lower through-hole 28 is positioned at the extreme lower position 8 of piston hole 22, and opening one end is positioned at the intersection of piston hole 22 and cup body 2 inwalls, and the other end drops on the position of piston hole 22 projections and test chamber 32 inwalls.Last through hole 27 and lower through-hole 28 are banded circular arc, and the opening two ends are 100 degree with the angle that the longitudinal axis by piston hole 22 forms.Last through hole 27 and lower through-hole 28 are not in same plane.
As Figure 12 and shown in Figure 13, piston 23 is when primary importance, and ring groove 26 is aimed at and gone up through hole 27.During use, bowl cover 1 is taken off, with liquid sample for example urine sample add a cup chamber, liquid sample flows to the cavity that ring groove 26 forms from last through hole 27.Again piston 23 is pushed piston hole 22 depths, make ring groove 26 aim at lower through-hole 28.At this moment, liquid sample flows into from lower through-hole 28 on the translot of cups 3, is flowing into slot from translot, contacts with test-strips on being inserted in slot, and testing result is shown.When needing further to detect, the liquid sample in the cup chamber can be delivered to the laboratory and further detect, confirm testing result by the professional.
Embodiment 2: difference from Example 1 is:
As Fig. 6 and shown in Figure 11, last through hole 27 is positioned at the extreme higher position 7 of piston hole 22, is 90 degree openings, and the opening two ends are all dropped on the outer wall of piston hole 22, and the angle that the last via openings and the longitudinal axis form respectively is 45 degree, and the opening two ends of last through hole 27 are in longitudinal axis two ends symmetry.Lower through-hole 28 is positioned at the extreme lower position 8 of piston hole 22, also is the opening of 90 degree, and the opening two ends of lower through-hole 28 are in the two ends of longitudinal axis symmetry.Last lower through-hole 28 is not in a logical plane, and when liquid sample was full of collecting chamber 21, last through hole 27 communicated with collecting chamber 21, and liquid sample enters in the ring groove 26 of piston hole 22.Piston 23 is pushed piston hole 22 depths, and ring groove 26 and lower through-hole 28 communicate, and liquid can flow into test chamber 32 whereby.
Embodiment 3: difference from Example 1 is:
As Fig. 7 and shown in Figure 10,28 of last through hole 27 and lower through-holes comprise two openings, and the size of each opening is 45 degree.Two openings of last through hole 27, an end of first opening are positioned at the intersection of piston hole 22 and cup body 2 inwalls, second opening the two ends symmetry in the both sides of the longitudinal axis, and be positioned between 7, two openings in extreme higher position of transfer chamber 22 and have little interval.Lower through-hole 28 also has two openings, be the 3rd opening and the 4th opening, an end of the 3rd opening also drops on the intersection of transfer chamber 22 and cup body 2 inwalls, and the two ends symmetry of the 4th opening is in the both sides of the longitudinal axis, be positioned between extreme lower position 8, the three openings of piston hole 22 and the 4th opening and exist at interval.Last through hole 27 and lower through-hole 28 are not in same plane, and first opening and second opening are in same plane, and the 3rd opening and the 4th opening are in same plane.Sample is collected by collecting chamber 21 earlier, and when collecting, a part of sample enters ring groove 26 in the piston hole 22 by last through hole 27.When promoting piston 23 inwards the time, the liquid in the ring groove 26 is stayed wherein, and when lower through-hole 28 and ring groove 26 communicated, liquid sample can enter test chamber 32 by lower through-hole 28, finishes immune detection.
Claims (14)
1. liquid sample collection and detection device, comprise collecting chamber, test chamber, and the transfer chamber that connects collecting chamber and test chamber, transfer chamber communicates with collecting chamber and test chamber respectively by at least two through holes, it is characterized in that, wherein the opening two ends of at least one through hole be positioned at transfer chamber the extreme higher position both sides or be positioned at the both sides of the extreme lower position of transfer chamber.
2. liquid sample collection and detection device according to claim 1 is characterized in that, opening one end of described through hole drops on the transverse axis.
3. liquid sample collection and detection device according to claim 2 is characterized in that, the opening two ends of through hole are spent less than 180 greater than 90 degree with the angle that the longitudinal axis that passes through transfer chamber forms.
4. liquid sample collection and detection device according to claim 3 is characterized in that, the opening two ends of through hole are 100 degree with the angle that the longitudinal axis by transfer chamber forms.
5. liquid sample collection and detection device according to claim 1 is characterized in that the opening of through hole departs from transverse axis and vertical pivot.
6. liquid sample collection and detection device according to claim 5 is characterized in that, the opening two ends of through hole are 90 degree with the angle that the longitudinal axis that passes transfer chamber forms.
7. liquid sample collection and detection device as claimed in claim 1, it is characterized in that, transfer chamber comprises two through holes, and the via openings two ends that communicate with collecting chamber are positioned at the both sides of the extreme higher position of transfer chamber, and the opening two ends of the through hole that communicates with test chamber are positioned at the both sides of the extreme lower position of transfer chamber.
8. liquid sample collection and detection device according to claim 7 is characterized in that, what communicate with collecting chamber is last through hole, and what communicate with test chamber is lower through-hole, and last through hole and lower through-hole are not in same plane.
9. liquid sample collection and detection device according to claim 8 is characterized in that, comprises on the transfer chamber that two are gone up through hole and two lower through-holes.
10. liquid sample collection and detection device according to claim 9 is characterized in that, the angle that the opening two ends of through hole become with the longitudinal axis that passes transfer chamber is less than 90 degree.
11. liquid sample collection and detection device according to claim 10 is characterized in that, the opening two ends of through hole are 45 degree with the angle that the longitudinal axis that passes transfer chamber forms.
12. liquid sample collection and detection device according to claim 8 is characterized in that, transfer chamber is a piston hole, and xsect is circular, and last through hole and lower through-hole are circular arc.
13. liquid sample collection and detection device according to claim 12 is characterized in that, comprises the piston that the energy slipper seal cooperates in the piston hole.
14. liquid sample collection and detection device according to claim 13 is characterized in that piston nose has ring groove, when communicating with collecting chamber by last through hole, isolates with test chamber; When communicating with test chamber, isolate with collecting chamber by lower through-hole.
Priority Applications (1)
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| CNU2007203031011U CN201159737Y (en) | 2007-12-10 | 2007-12-10 | Liquid sample collection and detection apparatus |
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| CNU2007203031011U CN201159737Y (en) | 2007-12-10 | 2007-12-10 | Liquid sample collection and detection apparatus |
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| CN101957274A (en) * | 2010-08-24 | 2011-01-26 | 苏州聚阳环保科技有限公司 | Multichannel block for taking liquid |
| WO2011017911A1 (en) * | 2009-08-13 | 2011-02-17 | Alere Switzerland Gmbh | Detection device and method of using the same |
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