CN1985987B - 甘草酸或其盐和还原型谷胱甘肽的药物组合物 - Google Patents
甘草酸或其盐和还原型谷胱甘肽的药物组合物 Download PDFInfo
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- CN1985987B CN1985987B CN200510045378A CN200510045378A CN1985987B CN 1985987 B CN1985987 B CN 1985987B CN 200510045378 A CN200510045378 A CN 200510045378A CN 200510045378 A CN200510045378 A CN 200510045378A CN 1985987 B CN1985987 B CN 1985987B
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组别 | 给药剂量(mg/kg) | 治疗前DHBV-DNA滴度 | 治疗后7dDHBV-DNA滴度 | 治疗后14dDHBV-DNA滴度 | 停药后3dDHBV-DNA滴度 |
空白对照组 | - | 1.59±0.05 | 1.60±0.04 | 1.58±0.05 | 1.60±0.03 |
阳性对照组 | 50 | 1.61±0.04 | 0.82±0.15<sup>**&&</sup> | 0.79±0.16<sup>**&&</sup> | 1.59±0.03 |
甘草酸二铵组 | 60 | 1.57±0.05 | 1.30±0.07<sup>*&</sup> | 1.29±0.07<sup>*&</sup> | 1.39±0.06<sup>*&</sup> |
还原型谷胱甘肽组 | 100 | 1.60±0.04 | 1.28±0.09<sup>*&</sup> | 1.30±0.09<sup>*&</sup> | 1.38±0.07<sup>*&</sup> |
甘谷组合物注射液组(低剂量) | 60 | 1.58±0.05 | 1.00±0.12<sup>**&&#△</sup> | 0.95±0.10<sup>**&&#△</sup> | 1.02±0.09<sup>**&&#△</sup> |
甘谷组合物注射液组(中剂量) | 80 | 1.59±0.03 | 0.96±0.13<sup>**&&#△</sup> | 0.91±0.14<sup>**&&#△</sup> | 1.00±0.09<sup>**&&#△</sup> |
甘谷组合物注射液组(高剂量) | 100 | 1.57±0.04 | 0.90±0.15<sup>**&&#△</sup> | 0.83±0.16<sup>**&&#△</sup> | 0.93±0.14<sup>**&&#△</sup> |
组别 | 给药剂量(mg/kg) | ALT/U·L<sup>-1</sup> | AST/U·L<sup>-1</sup> | TP/g·L<sup>-1</sup> | Alb/g·L<sup>-1</sup> | A/G |
空白对照组 | 10 | 53.5±12.6 | 81.6±16.3 | 51.9±5.6 | 24.6±2.5 | 0.90±0.35 |
模型组 | 10 | 109.6±15.3<sup>**</sup> | 103.9±12.2<sup>**</sup> | 88.1±9.7<sup>**</sup> | 15.6±3.3<sup>**</sup> | 0.22±0.08<sup>**</sup> |
甘草酸单铵组 | 40 | 79.3±13.6<sup>*#</sup> | 92.4±13.8<sup>*#</sup> | 73.8±8.9<sup>*#</sup> | 18.7±3.0<sup>*#</sup> | 0.34±0.15<sup>*#</sup> |
还原型谷胱甘肽组 | 100 | 78.6±12.5<sup>*#</sup> | 93.1±12.9<sup>*#</sup> | 74.1±9.0<sup>*#</sup> | 18.9±2.8<sup>*#</sup> | 0.34±0.13<sup>*#</sup> |
甘谷组合物注射液组(低剂量) | 20 | 59.5±10.6<sup>##&★</sup> | 84.6±15.2<sup>##&★</sup> | 61.6±7.1<sup>##&★</sup> | 22.3±2.7<sup>##&★</sup> | 0.57±0.29<sup>##&★</sup> |
甘谷组合物注射液组(中剂量) | 40 | 58.4±9.8<sup>##&★</sup> | 83.7±15.6<sup>##&★</sup> | 58.5±6.4<sup>##&★</sup> | 23.1±2.6<sup>##&★</sup> | 0.65±0.31<sup>##&★</sup> |
甘谷组合物注射液组(高剂量) | 80 | 55.8±10.3<sup>##&★</sup> | 82.5±15.9<sup>##&★</sup> | 53.8±6.0<sup>##&★</sup> | 23.9±2.8<sup>##&★</sup> | 0.80±0.34<sup>##&★</sup> |
组别 | 给药剂量(mg/kg) | 体重(g) | 肝脏重(g) | 肝脏系数 |
正常大鼠组 | - | 178 | 10.680 | 0.060±0.005 |
模型组 | 5 | 151 | 12.835 | 0.085±0.012<sup>**</sup> |
DEN+甘草酸二铵组 | 60 | 162 | 12.474 | 0.077±0.009<sup>*#</sup> |
DEN+还原型谷胱甘肽组 | 100 | 159 | 11.925 | 0.075±0.008<sup>*#</sup> |
DEN+甘谷组合物注射液组(低剂量) | 60 | 168 | 11.088 | 0.066±0.006<sup>##&★</sup> |
DEN+甘谷组合物注射液组(中剂量) | 80 | 173 | 11.072 | 0.064±0.005<sup>##&★</sup> |
DEN+甘谷组合物注射液组(高剂量) | 100 | 175 | 10.675 | 0.061±0.004<sup>##&★</sup> |
Claims (4)
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CN200510045378A CN1985987B (zh) | 2005-12-19 | 2005-12-19 | 甘草酸或其盐和还原型谷胱甘肽的药物组合物 |
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CN200510045378A CN1985987B (zh) | 2005-12-19 | 2005-12-19 | 甘草酸或其盐和还原型谷胱甘肽的药物组合物 |
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CN1985987A CN1985987A (zh) | 2007-06-27 |
CN1985987B true CN1985987B (zh) | 2010-05-12 |
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CN200510045378A Expired - Fee Related CN1985987B (zh) | 2005-12-19 | 2005-12-19 | 甘草酸或其盐和还原型谷胱甘肽的药物组合物 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016203499A1 (en) | 2015-06-19 | 2016-12-22 | Chigurupati Harsha | Synergistic beverage composition |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1611260A (zh) * | 2003-11-01 | 2005-05-04 | 杨喜鸿 | 阿德福韦酯的组合用药物 |
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Patent Citations (1)
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CN1611260A (zh) * | 2003-11-01 | 2005-05-04 | 杨喜鸿 | 阿德福韦酯的组合用药物 |
Non-Patent Citations (8)
Title |
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李X、金亦涛,邱蓉丽.甘草酸类药物的研究进展及应用.抗感染药学1 3.2004,1(3),103-105,126. |
李X、金亦涛,邱蓉丽.甘草酸类药物的研究进展及应用.抗感染药学1 3.2004,1(3),103-105,126. * |
李晓学,温文秀.甘草酸及其衍生物的制备与应用.中国医药工业杂志24 10.2004,24(10),475-478. |
李晓学,温文秀.甘草酸及其衍生物的制备与应用.中国医药工业杂志24 10.2004,24(10),475-478. * |
李荣洲等.甘草酸二铵联合还原型谷胱甘肽治疗酒精性肝炎疗效观察.江西医药39 4.2004,39(4),244. |
李荣洲等.甘草酸二铵联合还原型谷胱甘肽治疗酒精性肝炎疗效观察.江西医药39 4.2004,39(4),244. * |
汤萍等.还原型谷胱甘肽联合甘草酸二铵治疗慢性乙型肝炎62例.临床药学13 11.2004,13(11),65-66. |
汤萍等.还原型谷胱甘肽联合甘草酸二铵治疗慢性乙型肝炎62例.临床药学13 11.2004,13(11),65-66. * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016203499A1 (en) | 2015-06-19 | 2016-12-22 | Chigurupati Harsha | Synergistic beverage composition |
US10456359B2 (en) | 2015-06-19 | 2019-10-29 | Harsha Chigurupati | Synergistic beverage composition |
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