CN1980930B - 8-[3-氨基-哌啶-1-基]-黄嘌呤,其制备及dpp-ⅳ抑制剂形式的用途 - Google Patents
8-[3-氨基-哌啶-1-基]-黄嘌呤,其制备及dpp-ⅳ抑制剂形式的用途 Download PDFInfo
- Publication number
- CN1980930B CN1980930B CN2005800054231A CN200580005423A CN1980930B CN 1980930 B CN1980930 B CN 1980930B CN 2005800054231 A CN2005800054231 A CN 2005800054231A CN 200580005423 A CN200580005423 A CN 200580005423A CN 1980930 B CN1980930 B CN 1980930B
- Authority
- CN
- China
- Prior art keywords
- methyl
- benzyl
- cyanic acid
- xanthine
- butyne
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 CC#CC[n]1c(N(CCC2)C[C@@]2N)nc(N(C)C(N2*)=O)c1C2=* Chemical compound CC#CC[n]1c(N(CCC2)C[C@@]2N)nc(N(C)C(N2*)=O)c1C2=* 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102004008112.3 | 2004-02-18 | ||
DE102004008112A DE102004008112A1 (de) | 2004-02-18 | 2004-02-18 | 8-[3-Amino-piperidin-1-yl]-xanthine, deren Herstellung und Verwendung als Arzneimittel |
DE102004012921.5 | 2004-03-17 | ||
DE102004012921A DE102004012921A1 (de) | 2004-03-17 | 2004-03-17 | 8-[3-Amino-piperidin-1-yl]-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
DE102004032263.5 | 2004-07-03 | ||
DE102004032263A DE102004032263A1 (de) | 2004-07-03 | 2004-07-03 | 8-[3-Amino-piperidin-1yl]-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
PCT/EP2005/001427 WO2005085246A1 (de) | 2004-02-18 | 2005-02-12 | 8-[3-amino-piperidin-1-yl]-xanthine, deren herstellung und deren verwendung als dpp-iv hemmer |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2011100842167A Division CN102199151A (zh) | 2004-02-18 | 2005-02-12 | 8-[3-氨基-哌啶-1-基]-黄嘌呤、制备及用途 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1980930A CN1980930A (zh) | 2007-06-13 |
CN1980930B true CN1980930B (zh) | 2012-11-21 |
Family
ID=34813493
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2005800054231A Active CN1980930B (zh) | 2004-02-18 | 2005-02-12 | 8-[3-氨基-哌啶-1-基]-黄嘌呤,其制备及dpp-ⅳ抑制剂形式的用途 |
Country Status (5)
Country | Link |
---|---|
CN (1) | CN1980930B (xx) |
AR (1) | AR115411A2 (xx) |
DE (1) | DE102004008112A1 (xx) |
UA (1) | UA87835C2 (xx) |
ZA (1) | ZA200604281B (xx) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20090938A1 (es) * | 2007-08-16 | 2009-08-08 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende un derivado de benceno sustituido con glucopiranosilo |
DE102008010661A1 (de) * | 2008-02-22 | 2009-09-03 | Dr. Felix Jäger und Dr. Stefan Drinkuth Laborgemeinschaft OHG | Verfahren zur Herstellung von Pyridin-2-Boronsäure und Derivaten davon |
CN102311448B (zh) * | 2010-07-07 | 2014-02-19 | 中国科学院广州生物医药与健康研究院 | 噻吩并嘧啶酮类dpp-iv抑制剂 |
ES2713566T3 (es) * | 2011-07-15 | 2019-05-22 | Boehringer Ingelheim Int | Derivado de quinazolina dimérico sustituido, su preparación y su uso en composiciones farmacéuticas para el tratamiento de la diabetes de tipo I y II |
CN103450201B (zh) * | 2012-05-30 | 2017-04-12 | 博瑞生物医药(苏州)股份有限公司 | 手性8‑(3‑氨基哌啶‑1‑基)‑黄嘌呤的制备方法 |
CN103709163B (zh) * | 2012-09-29 | 2016-12-21 | 齐鲁制药有限公司 | 黄嘌呤衍生物、其制备方法及用途 |
CN103319483B (zh) * | 2012-10-19 | 2016-08-03 | 药源药物化学(上海)有限公司 | 一种利拉列汀重要中间体的制备方法 |
CN106008507B (zh) * | 2013-01-23 | 2017-11-28 | 成都苑东生物制药股份有限公司 | 黄嘌呤衍生物 |
CN106188058B (zh) * | 2015-05-29 | 2020-11-06 | 江苏天士力帝益药业有限公司 | 黄嘌呤衍生物 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002068420A1 (de) * | 2001-02-24 | 2002-09-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Xanthinderivate, deren herstellung und deren verwendung als arzneimittel |
-
2004
- 2004-02-18 DE DE102004008112A patent/DE102004008112A1/de not_active Withdrawn
-
2005
- 2005-02-12 UA UAA200609881A patent/UA87835C2/ru unknown
- 2005-02-12 CN CN2005800054231A patent/CN1980930B/zh active Active
-
2006
- 2006-05-26 ZA ZA200604281A patent/ZA200604281B/en unknown
-
2019
- 2019-05-22 AR ARP190101358A patent/AR115411A2/es unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002068420A1 (de) * | 2001-02-24 | 2002-09-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Xanthinderivate, deren herstellung und deren verwendung als arzneimittel |
Also Published As
Publication number | Publication date |
---|---|
DE102004008112A1 (de) | 2005-09-01 |
UA87835C2 (xx) | 2009-08-25 |
AR115411A2 (es) | 2021-01-13 |
CN1980930A (zh) | 2007-06-13 |
ZA200604281B (en) | 2007-10-31 |
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