CN1977926B - Application of ampelopsis for preparing medicine for promoting wound quick healing - Google Patents
Application of ampelopsis for preparing medicine for promoting wound quick healing Download PDFInfo
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- CN1977926B CN1977926B CN2006101240826A CN200610124082A CN1977926B CN 1977926 B CN1977926 B CN 1977926B CN 2006101240826 A CN2006101240826 A CN 2006101240826A CN 200610124082 A CN200610124082 A CN 200610124082A CN 1977926 B CN1977926 B CN 1977926B
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- ampelopsis grossedentata
- wound
- ampelopsis
- fine powder
- extract
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Abstract
The present invention relates to a kind of preparation of external application. Said preparation for external application is made up by using folk health-care tea Teng-tea. Said serier preparation for external application can be used for promoting surface of wound be quickly and effectively healed.
Description
Technical field:
Technical field: the present invention relates to a kind of application of Chinese herbal medicine, especially have the effect of promotion wound healing and made preparation thereof.
Background technology:
Background technology: wound surface and wound heal fast and effectively, all are crucial undoubtedly for all patients.Quite a lot of wound healing abilities lowly or because of wound surface does not heal rapidly just have the patient of very high complication rate, as diabetes, accept patients such as hormone therapy, large tracts of land or serious tissue injury, if wound surface can not quickly-healing even can be had influence on the safety of life, should manage to seek the healing of wound surface as early as possible, therefore how to promote that wound surface heals fast and effectively, be one of the field of medical circle persistent exploration and direction always.
Ampelopsis grossedentata is the young stem and leaf of Vitaceae ampelopsis Ampelopsis grossedentata Ampelasis grossedentata (Hand.-Mazz) W.T.Wang.Extensively be distributed in each province, China south, have effects such as heat-clearing and toxic substances removing.Provinces and regions such as Guangxi, the Hunan Zhuang and the common people of the Yao nationality often are made into health tea, are used for the treatment of flu, heating, heatstroke, dizziness, disease such as vexed.But Ampelopsis grossedentata is used to promote the application of wound healing not see that clinical report is arranged.
Summary of the invention:
Summary of the invention: it is the new purposes of Ampelopsis grossedentata that a kind of crude drug is provided, and it has the effect that promotes wound surface and wound healing and be made into various preparations and is applied to clinical.
The specific embodiment:
The specific embodiment: be ground into fine powder (100 ~ 120 order) after the essence extract of the alcohol extract of the water extract of Ampelopsis grossedentata, Ampelopsis grossedentata, Ampelopsis grossedentata or other solvents dried separately, make external pulvis respectively, be spread in the wound affected part, they all can play the effect that promotes healing wound fast equally.
Ampelopsis grossedentata of the present invention is used and is stated the external pulvis except that allowing, and also method for making is made other external preparation routinely, as gel, ointment, lotion, adhesive bandage, aerosol or spray etc., is applied to the wound affected part and plays and promote the function that recovers from injury.
The present invention makes pharmacological evaluation through the external pulvis with Ampelopsis grossedentata with traditional wound healing Chinese patent medicine, and the external pulvis of pharmacological tests explanation Ampelopsis grossedentata has the effect that fast, effectively promotes wound healing.
The pharmacological evaluation of wound healing
Get 30 of the Wistar rats (male and female half and half, female unpregnancy) of body weight 200 ~ 300g, be divided into four groups at random, 8 of one, two group of every group of rats, three, four groups of every group of rats are 7.Carry out disinfection after the unhairing of both sides, experimental rat back, cut off skin as groined type, the long 2 ~ 3cm of the edge of a knife of both sides with the scalpel of sterilizing, the about at interval 1cm of the edge of a knife, cutter is deep to Musclar layer, an edge-on medicine of promptly putting, opposite side compares, and covers with two-layer gauze, the sealing of reuse nonirritant adhesive plaster.The medicine of putting: one group is the fine powder of Ampelopsis grossedentata, and two groups is the fine powder of extract white of Ampelopsis grossedentata, and three groups is YUNNAN BAIYAO, and four groups is the fine powder of chitin.Respectively all at 6 hours, 24 hours, 48 hours, checked the situation of all wounds, result of experiment such as following table in 72 hours .96 hour:
The promoting healing effect that Ampelopsis grossedentata and extract thereof lancinate and hinder rat skin
Annotate: compare with control sides: 1) P＜0.001,2) P＞0.05
Find from the situation that the laboratory animal inspection is observed; the wound redness that rat is put the diffusing medicine side of Ampelopsis grossedentata disappears soon; and not having exudate produces; the wound place forms effective protective layer; really played the healing effect fast and effectively of promotion wound; and compare with two medicines of positive control, the Ampelopsis grossedentata external is loose and the external of Ampelopsis grossedentata extract is loose all is better than positive control drug.
Preliminary clinical operating position:
On probation when volunteer's wound no matter be fresh wound or old wound, looses, all can receive behind the powder of external extract, gel the effect of healing wound in 24h in the external of using Ampelopsis grossedentata.
Huang for example, the male, 35 years old calendar year 2001 JIUYUE * * collided by truck during day by motorcycle, thigh and upper limb Multiple Wounds are sealed wound with dressing after being placed on each injury with Ampelopsis grossedentata extrat, all healings in second day of three place's wounds, redness disappears, i.e. recovery from illness after several days.
Gold certain, male, 28 years old lower limb knee of damaging accidentally in August, 2003, the about 10cm of wound
2, the hospital outpatient Surgery Treatment after 3 days wound still have and ooze out, after the gel made from Ampelopsis grossedentata extrat is applied to wound surface, promptly heal at second day wound, the weather sweltering heat can normally be had a bath, recovery from illness after several days.
Dragon certain, the male, 46 years old, once use Ampelopsis grossedentata loose extract and gel because of wound three times, all bathe the back at night and use, can heal second day morning.
Embodiment:
1. the young stem and leaf of getting Ampelopsis grossedentata is ground into fine powder (100 ~ 120 order) and is external pulvis 100 ~ 105 ℃ of oven dry.
2. get Ampelopsis grossedentata and be ground into coarse powder, boil with ordinary water and extract 2 times, the extracting solution filtered while hot, merging filtrate also is concentrated into certain volume, puts cryoprecipitate, and 48 hours after-filtration with the precipitate oven dry, are ground into fine powder (100 ~ 120 order), promptly get the external pulvis of water extract.
3. alcohol extract: get Ampelopsis grossedentata and be ground into coarse powder, add the alcohol reflux secondary, merge extractive liquid,, reclaim ethanol after, with the precipitate oven dry, be ground into fine powder and be external pulvis.The oven dry of the precipitate of also available enforcement 2 water extraction extracts twice again with ethanol, filters extracting solution, merge, be concentrated into dried, dry, be ground into fine powder promptly.
4. the external pulvis of extract: with the water extract of embodiment 2, add proper amount of acetone dissolving and extract secondary, 20% ~ 30% the active carbon that adds water extract weight reflux decolour to the acetone solution, filtering decarbonization, acetone solution is to colourless, reclaim acetone to only remaining small amount of acetone, add 20 times of amount distilled water, separate out white precipitate, refrigerator cold-storage 24h, filtered in second day, washing, dry, be ground into fine powder, the gained white powder is purified external pulvis.
5. the white powder that the fine powder of above-mentioned Ampelopsis grossedentata, Ampelopsis grossedentata water extract, Ampelopsis grossedentata ethanol extract, Ampelopsis grossedentata essence are carried is made suspendible or latex stiff or semisolid gel with the adjuvant that can form gel.
6. the various ointments of the Ampelopsis grossedentata that the substrate mix homogeneously of the white fine powder of Ampelopsis grossedentata fine powder, Ampelopsis grossedentata water extract fine powder, Ampelopsis grossedentata ethanol extract fine powder, Ampelopsis grossedentata extract and ointment is made.
7. getting the fine powder of white of fine powder, extract of fine powder, the Ampelopsis grossedentata ethanol extract of fine powder, the water extract of Ampelopsis grossedentata and adjuvant has managed and has been mixed with suspendible shape, lactous lotion.
8. make the adhesive bandage of all size size according to the size of wound surface, the middle sterile gauze that plays the drug effect part can be coated with the gel of the foregoing description 5, the ointment coating of also available embodiment 6, also available in addition other adjuvants are with the fine powder of Ampelopsis grossedentata, or the various extracts of Ampelopsis grossedentata, anchor at intermediary sterile gauze, promptly can be made into the short more adhesive bandage of effect of wound.
9. the fine powder of the fine powder of the various extracts of Ampelopsis grossedentata or Ampelopsis grossedentata is contained in the withstand voltage tight envelope container with special valve system by the pressure of propellant,, makes the aerosol of Ampelopsis grossedentata and extract thereof the content ejection.Also above-mentioned fine powder can be contained in the container that does not contain propellant by the pressure ejection content of manual pump and make spray.
10. all kinds of preparations that above embodiment makes all can be used for patient's wound surface and wound and play the effect that promotes quickly-healing.
Claims (1)
1. Ampelopsis grossedentata has the application that promotes in the wound quick healing effect medicine in preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006101240826A CN1977926B (en) | 2006-11-30 | 2006-11-30 | Application of ampelopsis for preparing medicine for promoting wound quick healing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006101240826A CN1977926B (en) | 2006-11-30 | 2006-11-30 | Application of ampelopsis for preparing medicine for promoting wound quick healing |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1977926A CN1977926A (en) | 2007-06-13 |
| CN1977926B true CN1977926B (en) | 2010-06-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2006101240826A Expired - Fee Related CN1977926B (en) | 2006-11-30 | 2006-11-30 | Application of ampelopsis for preparing medicine for promoting wound quick healing |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102771594A (en) * | 2011-05-13 | 2012-11-14 | 贵州省生物研究所 | Antibacterial, inflammation-diminishing, and analgesic Ampelopsis grossedentata preparation and preparation method thereof |
| CN104666873B (en) * | 2015-02-17 | 2018-01-09 | 北京工商大学 | External medicine composition, preparation with the antipruritic anti-inflammatory efficacies of Shu Min and preparation method thereof |
| CN106691902B (en) | 2015-08-14 | 2021-04-20 | 强生消费者公司 | Compositions comprising extracts of Ampelopsis grossedentata and Albizzia julibrissin and methods of use |
| CN107669757A (en) * | 2017-09-28 | 2018-02-09 | 禹华刚 | Promote dressing of wound healing and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1209957A (en) * | 1998-09-08 | 1999-03-10 | 江西省赣南保健茶厂 | Cane tea and preparation thereof |
| CN1711918A (en) * | 2004-06-25 | 2005-12-28 | 广东省农业科学院蚕业与农产品加工研究所 | Production of vine tea mother liquid |
| CN1850069A (en) * | 2006-02-28 | 2006-10-25 | 广西中医学院 | Method for preparing Tengchasu dispersibletablet and its use |
-
2006
- 2006-11-30 CN CN2006101240826A patent/CN1977926B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1209957A (en) * | 1998-09-08 | 1999-03-10 | 江西省赣南保健茶厂 | Cane tea and preparation thereof |
| CN1711918A (en) * | 2004-06-25 | 2005-12-28 | 广东省农业科学院蚕业与农产品加工研究所 | Production of vine tea mother liquid |
| CN1850069A (en) * | 2006-02-28 | 2006-10-25 | 广西中医学院 | Method for preparing Tengchasu dispersibletablet and its use |
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| Publication number | Publication date |
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| CN1977926A (en) | 2007-06-13 |
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