CN105832817B - Application of pyrroloquinoline quinine to pharmaceutical compositions for treatment of burns, scalds and traumas - Google Patents
Application of pyrroloquinoline quinine to pharmaceutical compositions for treatment of burns, scalds and traumas Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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Abstract
The invention provides application of pyrroloquinoline quinine to pharmaceutical compositions for treatment of burns, scalds and traumas. Pyrroloquinoline quinine is applied in the form of a composition. The composition is prepared from, by weight, 1-8 parts of pyrroloquinoline quinine, 2-9 parts of artemisinin, 2-8 parts of mint and 1-9 parts of allicin. Pyrroloquinoline quinine is applied in the form of the composition, in the process of treating the scalds, the burns and the traumas, regeneration and healing of trauma parts are promoted, the effects of stopping pain and subsiding swelling, removing necrotic tissue and promoting granulation, clearing away heat and toxic materials, achieving astriction and resisting bacteria are achieved, a good treatment effect is achieved for various trauma skin infections or deep skin tissue anabrosis which is not cured for a long time, face scars are removed, and the advantages that the pain of patients is small, wound healing is rapid, the wound surface restoration effect is good, the treatment time is short, the restoration effect is good, no scar is left, and face whitening and ultraviolet resisting are achieved.
Description
Technical field
The present invention relates to burn, scald and wound aspect medicine technology field, especially relate to pyrroloquinoline quinone in preparation
Application for treatment burn, scald and wound aspect.
Background technology
With the high speed development of urban industry, traffic, building industry etc., and the generation of natural disaster and accident, people
The probability that comes to harm of body increasing, the burn, scald and the wound that cause also become increasingly complex.Scald refers to outside human body
The accidental injury formula symptom that epidermis skin tissue is destroyed by high-temp liquid contact injury, burn refers to that human body appearance skin histology is bright
Fire contact or the closely vehement roasting and damage formula symptom of the destruction that comes to harm.Scald and burn is all high temperature to human skin tissue
Attack destroy, cause the death of skin tissue cell, make skin histology can not exercise its normal physiological function again, thus enter one
Step threatens the tissue of impact skin bottom.This destructiveness can not only be expressed with destruction, but to be expressed with removing and disappearing,
The skin bottom tissue making one comes out, and without the regeneration basis of skin, and the skin of surrounding also will not be to side hypertrophy.
People's treatment at present is scalded and is burnt, and typically just tackles infection with antibiotic or some antibacterial medicines and festers, has
Blindly carelessly smear Chinese medicine at wound area position, the injury effect playing be more than therapeutical effect.Existing treatment skin
The medicine of burn and scald also have multiple, including Chinese medicine and Western medicine, for example conventional traditional Chinese herb medicine have JINGWANHONG RUANGAO, ointment for treating burn and scald,
Moist expose burn ointment etc.；Western medicine ointment has tetracycline ointment, oxytetracycline ointment, chloromycetin ointment, erythromycin ointment, Ciprofloxacin soft
Cream, norfloxacin ointment etc..According to Clinical practice for many years it has been observed that moist expose burn ointment curative effect is slightly good, but some patients make
With after allergic phenomena occurs, therapeutic domain has certain limitation.Western medicine burn and scald, skin injury have certain controls curative effect
Really, but fall within selective application, it can therefore be appreciated that existing medicine burn, scald and wound in terms of therapeutic effect not
It is fine, wound healing is slow, can also leave cicatrix.
Content of the invention
In order to overcome the problems referred to above, the present invention to society provide pyrroloquinoline quinone preparation for treatment burn, scald and
The application of wound aspect, patient ache after a procedure bitter little, wound healing is fast, wound surface recovery effects are good, treatment time is short, extensive
Multiple effect is good and preventing from scar.
The technical scheme is that：Offer pyrroloquinoline quinone is in terms of preparation is for treatment burn, scald and wound
Application, wherein, described pyrroloquinoline quinone is applied in the form of compositions, and described compositionss are by the medicine system of following composition by weight
Become：Pyrroloquinoline quinone 1-8 part, arteannuin 2-9 part, Herba Menthae 2-8 part, garlicin 1-9 part.
As improvement of the present invention, described compositionss are to be made up of the medicine of following composition by weight：Pyrroloquinoline quinone
2-7 part, arteannuin 3-8 part, Herba Menthae 3-7 part, garlicin 2-8 part.
As improvement of the present invention, described compositionss are to be made up of the medicine of following composition by weight：Pyrroloquinoline quinone
3-6 part, arteannuin 4-7 part, Herba Menthae 4-6 part, garlicin 3-7 part.
As improvement of the present invention, described compositionss are to be made up of the medicine of following composition by weight：Pyrroloquinoline quinone 5
Part, 6 parts of arteannuin, 5 parts of Herba Menthae, 5 parts of garlicin.
As improvement of the present invention, the dosage form of described compositionss includes：Powder agent, solution, spray or ointment.
As improvement of the present invention, described pyrroloquinoline quinone is made by pure natural.
Present invention employs and state pyrroloquinoline quinone and apply in the form of compositions, scald in treatment, the mistake of burn and wound
Cheng Zhong, promotes regeneration and the healing of wound site, has alleviating pain and detumescence, removing the necrotic tissue and promoting granulation, heat-clearing and toxic substances removing, restrains effect of antibacterial,
And also to various wound skin infections, or the preferable effect treatment that long-term not deep skin histology ulcer more etc. is equal, dispel face
Portion's cicatrix, have patient's pain bitter little, wound healing is fast, wound surface recovery effects are good, treatment time is short, recovery effects good, no
Stay the advantages of cicatrix, face's whitening and uvioresistant.
Specific embodiment
First, research worker is based on years of researches and finds that pyrroloquinoline quinone has very in terms for the treatment of burn, scald and wound
It is that pyrroloquinoline quinone is used for treatment burn, scalds and wound side in preparation that good using value, the therefore present invention need to be protected
The application in face, wherein, described pyrroloquinoline quinone is applied in the form of compositions, and described compositionss are by the medicine of following composition by weight
Thing is made：Pyrroloquinoline quinone 1-8 part, arteannuin 2-9 part, Herba Menthae 2-8 part, garlicin 1-9 part.
In the present invention, the dosage form of described compositionss includes：Powder agent, solution, spray or ointment, described pyrroles's quinoline
Quinone is made by pure natural.
In the present invention, the preparation method of described compositionss, comprise the steps：
（100）, take 2-8 part（Composition by weight）Herba Menthae：
（200）, Herba Menthae is soaked the scheduled time, then to soak after Herba Menthae decoct, decoct certain time
After obtain raw material medicinal liquid；
（300）, high speed centrifugation process is carried out to raw material medicinal liquid, go the removal of impurity, obtain medicinal liquid；
（400）, by pyrroloquinoline quinone 1-8 part（Composition by weight）, arteannuin 2-9 part（Composition by weight）With garlicin 1-9 part
（Composition by weight）It is added in medicinal liquid and obtain being mixed to get described compositionss；
（500）, described compositionss are sterilized and are filtered.
In the present invention, following examples are also included, following examples are used for the present invention is described, but are not limited to this
Bright scope.
Embodiment 1
First, 2 parts are taken（Composition by weight）Herba Menthae：
Secondly, Herba Menthae is soaked the scheduled time, then the Herba Menthae after soaking is decocted, after decocting certain time
Obtain raw material medicinal liquid；High speed centrifugation process is carried out to raw material medicinal liquid, goes the removal of impurity, obtain medicinal liquid；Then by 1 part of pyrroloquinoline quinone
（Composition by weight）, 2 parts of arteannuin（Composition by weight）With 1 part of garlicin（Composition by weight）It is added in medicinal liquid and obtain being mixed to get institute
State compositionss；Finally described compositionss are sterilized and filtered.
Embodiment 2
First, 3 parts are taken（Composition by weight）Herba Menthae：
Secondly, Herba Menthae is soaked the scheduled time, then the Herba Menthae after soaking is decocted, after decocting certain time
Obtain raw material medicinal liquid；High speed centrifugation process is carried out to raw material medicinal liquid, goes the removal of impurity, obtain medicinal liquid；Then by 2 parts of pyrroloquinoline quinone
（Composition by weight）, 3 parts of arteannuin（Composition by weight）With 2 parts of garlicin（Composition by weight）It is added in medicinal liquid and obtain being mixed to get institute
State compositionss；Finally described compositionss are sterilized and filtered.
Embodiment 3
First, 4 parts are taken（Composition by weight）Herba Menthae：
Secondly, Herba Menthae is soaked the scheduled time, then the Herba Menthae after soaking is decocted, after decocting certain time
Obtain raw material medicinal liquid；High speed centrifugation process is carried out to raw material medicinal liquid, goes the removal of impurity, obtain medicinal liquid；Then by 3 parts of pyrroloquinoline quinone
（Composition by weight）, 4 parts of arteannuin（Composition by weight）With 3 parts of garlicin（Composition by weight）It is added in medicinal liquid and obtain being mixed to get institute
State compositionss；Finally described compositionss are sterilized and filtered.
Embodiment 4
First, 4.7 parts are taken（Composition by weight）Herba Menthae：
Secondly, Herba Menthae is soaked the scheduled time, then the Herba Menthae after soaking is decocted, after decocting certain time
Obtain raw material medicinal liquid；High speed centrifugation process is carried out to raw material medicinal liquid, goes the removal of impurity, obtain medicinal liquid；Then by pyrroloquinoline quinone 3.4
Part（Composition by weight）, 4.5 parts of arteannuin（Composition by weight）With 3.5 parts of garlicin（Composition by weight）It is added in medicinal liquid and mixed
Obtain described compositionss；Finally described compositionss are sterilized and filtered.
Embodiment 5
First, 5 parts are taken（Composition by weight）Herba Menthae：
Secondly, Herba Menthae is soaked the scheduled time, then the Herba Menthae after soaking is decocted, after decocting certain time
Obtain raw material medicinal liquid；High speed centrifugation process is carried out to raw material medicinal liquid, goes the removal of impurity, obtain medicinal liquid；Then by 5 parts of pyrroloquinoline quinone
（Composition by weight）, 6 parts of arteannuin（Composition by weight）With 5 parts of garlicin（Composition by weight）It is added in medicinal liquid and obtain being mixed to get institute
State compositionss；Finally described compositionss are sterilized and filtered.
Embodiment 6
First, 6 parts are taken（Composition by weight）Herba Menthae：
Secondly, Herba Menthae is soaked the scheduled time, then the Herba Menthae after soaking is decocted, after decocting certain time
Obtain raw material medicinal liquid；High speed centrifugation process is carried out to raw material medicinal liquid, goes the removal of impurity, obtain medicinal liquid；Then by 6 parts of pyrroloquinoline quinone
（Composition by weight）, 7 parts of arteannuin（Composition by weight）With 7 parts of garlicin（Composition by weight）It is added in medicinal liquid and obtain being mixed to get institute
State compositionss；Finally described compositionss are sterilized and filtered.
Embodiment 7
First, 6.5 parts are taken（Composition by weight）Herba Menthae：
Secondly, Herba Menthae is soaked the scheduled time, then the Herba Menthae after soaking is decocted, after decocting certain time
Obtain raw material medicinal liquid；High speed centrifugation process is carried out to raw material medicinal liquid, goes the removal of impurity, obtain medicinal liquid；Then by pyrroloquinoline quinone 6.4
Part（Composition by weight）, 7.6 parts of arteannuin（Composition by weight）With 7.3 parts of garlicin（Composition by weight）It is added in medicinal liquid and mixed
Obtain described compositionss；Finally described compositionss are sterilized and filtered.
Embodiment 8
First, 7 parts are taken（Composition by weight）Herba Menthae：
Secondly, Herba Menthae is soaked the scheduled time, then the Herba Menthae after soaking is decocted, after decocting certain time
Obtain raw material medicinal liquid；High speed centrifugation process is carried out to raw material medicinal liquid, goes the removal of impurity, obtain medicinal liquid；Then by 7 parts of pyrroloquinoline quinone
（Composition by weight）, 8 parts of arteannuin（Composition by weight）With 8 parts of garlicin（Composition by weight）It is added in medicinal liquid and obtain being mixed to get institute
State compositionss；Finally described compositionss are sterilized and filtered.
Embodiment 9
First, 8 parts are taken（Composition by weight）Herba Menthae：
Secondly, Herba Menthae is soaked the scheduled time, then the Herba Menthae after soaking is decocted, after decocting certain time
Obtain raw material medicinal liquid；High speed centrifugation process is carried out to raw material medicinal liquid, goes the removal of impurity, obtain medicinal liquid；Then by 8 parts of pyrroloquinoline quinone
（Composition by weight）, 9 parts of arteannuin（Composition by weight）With 9 parts of garlicin（Composition by weight）It is added in medicinal liquid and obtain being mixed to get institute
State compositionss；Finally described compositionss are sterilized and filtered.
2nd, to illustrate pyrroloquinoline quinone in terms of preparation is for treatment burn, scald and wound below by clinical data
Application, wherein, described pyrroloquinoline quinone is applied in the form of described compositionss：
1st, clinical observation：Described compositionss in the present invention are carried out from 2006 to 2015 hospitals throughout the country
Since Clinical practice, burn, scald, scuffing, the patient 1000 of knife injury, hard defects and other wound are received and have cured altogether, wherein
Fire victim 300, scalds patient 400, scratches patient 100, knife injury patient 80, hard defects patient 70 and other wound
Patient 50.
2nd, instructions of taking：
Clean pollution wound surface with normal saline, distilled water, cold water or mineral water, person cuts off part bubble skin blister,
Blot wound surface cleanout fluid.Large area, deep burn patient directly described compositionss are coated on wound surface, later every 3
Hour coats once again, need not wrap up.Described compositionss are directly coated in wound surface by the burned patient for small areas
On, again coat once every 5 hours later, need not wrap up.Use described compositionss instead using other medicines, must be by wound surface
Left drug cleans up, and coats described compositionss after blotting cleanout fluid.Before next day medication, wound surface is cleaned with above-mentioned same method
Use described compositionss afterwards again, administration time is identical.During wound surface incrustation, it is sure not to think stripping crust so as to naturally come off, crust
After completely falling off, continuation medication 3-5 days, daily 2 times.
3rd, dietetic contraindication：Should not take with other Chinese medicines when taking simultaneously, give up alcohol, maror.
4th, efficacy result：
| Burn | Scald | Scratch | Knife injury | Hard defects | Other wounds | Total | |
| Case | 300 | 400 | 100 | 80 | 70 | 50 | 1000 |
| Cure number | 285 | 392 | 99 | 80 | 70 | 49 | 975 |
| Later stage festers | 15 | 8 | 1 | 0 | 0 | 1 | 25 |
| Cure rate | 95% | 985 | 1% | 100% | 100% | 98% | 97.5% |
The healing ultrahigh in efficiency of the present invention as can be seen from the table, reaches 97.5%, evident in efficacy.
5th, some cases data：
Case 1：Liu so-and-so, female, 25 years old, Foshan people from city, boiled water irons the back of the hand, serious local foaming scaling, profit
Smear only once week basic rehabilitation with heretofore described compositionss, epidermis does not stay cicatrix.
Case 2：Zhang, man, 10 years old, people from Changsha, accidentally falls in the lime pile in building site, left foot and leg are burnt
The swollen bubble of wound, the heretofore described compositionss of external, three times a day, and recovery from illness in 15 days, do not stay cicatrix.
Case 3：Hu, man, 55 years old, Hubei people from Jingmen, burnt by the iron plate burning red, epidermis is substantially downright bad, subcutaneous outer
See pale muddy or pale brown, the heretofore described compositionss of external, symptom substantially mitigates within 20 days, and gradually takes a turn for the better, neoplastic skin
Start to generate.
Case 4：King so-and-so, female, 19 years old, Hunan people from Shaoyang, during cooking, arm is scalded by boiled oil, utilizes
The present invention smears treatment, fully recovers after 15 days, no cicatrix.
Case 5：Zheng, man, 33 years old, liuyang hunan people, during firecrackers processed, gunpowder is ignited, the right hand of burning, profit
Smear treatment with the present invention, first applied with being changed to wiping after soak, fully recover after 14 days, do not stay cicatrix.
Case 6：Wu so-and-so, female, 2 years old, Sichuan people from Chengdu, accidentally by the just boiled scald right hand, local occur red and swollen,
The ulceration decortication of a large amount of blister parts, debridement immediately after being admitted to hospital, hinder face and apply the present invention, stopping of crying and screaming after 30 minutes, external this
Compositionss described in bright, recovery from illness discharge in 8 days.
Case 7：Leaf so-and-so, man, 40 years old, Chongqing people from Dazhou City, accidentally ride motor overturning wound, once certain hospital treat
15 days, doctor's suggestion selected a time dermatoplastic treatment it is considered to financial expenditure is big, and financial insolvency is left hospital automatically, later institute in the external present invention
State compositionss, wound healing discharge in 25 days, follow-up after half a year has no recurrence.
Case 8：What so-and-so, female, 45 years old, people from Hanzhong, no bright reason right crus of diaphragm skin ulcer is suppurated, and local hospital is wrapped up
Dressing infusion treatment one month, ulcer does not improve, the heretofore described compositionss of external later, and after 15 days, follow-up ulcer has been
Healing.
Case 9：Congratulate so-and-so, man, 55 years old, Shaanxi people from Xi'an, catch fire in family, by back large-area burns, external later is originally
Compositionss described in invention, recovery from illness discharge in 30 days.
State pyrroloquinoline quinone described in present invention employs to apply in the form of compositions, scald, burn and wound in treatment
During, promote regeneration and the healing of wound site, there is alleviating pain and detumescence, removing the necrotic tissue and promoting granulation, heat-clearing and toxic substances removing, the work(of convergence antibacterial
Effect, and also to various wound skin infections, or the preferable effect treatment that long-term not deep skin histology ulcer more etc. is equal, dispel
Face's cicatrix, have patient's pain bitter little, wound healing is fast, wound surface recovery effects are good, treatment time is short, recovery effects good,
The advantages of preventing from scar, face's whitening and uvioresistant.
Claims (6)
1. the application in pharmaceutical composition in terms of preparation is used for treatment burn, scald and wound for the pyrroloquinoline quinone, wherein, institute
State pyrroloquinoline quinone to apply in the form of compositions, described compositionss are to be made up of the medicine of following composition by weight：Pyrroles's quinoline
Quinoline quinone 1-8 part, arteannuin 2-9 part, Herba Menthae 2-8 part, garlicin 1-9 part.
2. according to claim 1 application it is characterised in that：Described compositionss are made up of the medicine of following composition by weight
's：Pyrroloquinoline quinone 2-7 part, arteannuin 3-8 part, Herba Menthae 3-7 part, garlicin 2-8 part.
3. according to claim 1 application it is characterised in that：Described compositionss are made up of the medicine of following composition by weight
's：Pyrroloquinoline quinone 3-6 part, arteannuin 4-7 part, Herba Menthae 4-6 part, garlicin 3-7 part.
4. according to claim 1 application it is characterised in that：Described compositionss are made up of the medicine of following composition by weight
's：5 parts of pyrroloquinoline quinone, 6 parts of arteannuin, 5 parts of Herba Menthae, 5 parts of garlicin.
5. the application according to any one claim in claim 1-4 it is characterised in that：The dosage form of described compositionss
Including：Powder agent, solution, spray or ointment.
6. the application according to any one claim in claim 1-4 it is characterised in that：Described pyrroloquinoline quinone is
Made by pure natural.
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| CN201610309901.8A CN105832817B (en) | 2016-05-11 | 2016-05-11 | Application of pyrroloquinoline quinine to pharmaceutical compositions for treatment of burns, scalds and traumas |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105147881A (en) * | 2015-10-28 | 2015-12-16 | 李琳 | Compound menthol balm for treating burns |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105147881A (en) * | 2015-10-28 | 2015-12-16 | 李琳 | Compound menthol balm for treating burns |
Non-Patent Citations (2)
| Title |
|---|
| 吡咯喹啉醌对放创性皮肤损伤促愈合研究;李皓桓等;《中华放射医学与防护杂志》;20050831;第25卷(第4期);第351-353页 * |
| 吡咯喹啉醌生理医学功效研究进展;孙静娴等;《生物学杂志》;20121231;第29卷(第6期);第80-83页 * |
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