CN109223931A - A kind of burn cream and preparation method thereof for treating burn - Google Patents

A kind of burn cream and preparation method thereof for treating burn Download PDF

Info

Publication number
CN109223931A
CN109223931A CN201811284828.9A CN201811284828A CN109223931A CN 109223931 A CN109223931 A CN 109223931A CN 201811284828 A CN201811284828 A CN 201811284828A CN 109223931 A CN109223931 A CN 109223931A
Authority
CN
China
Prior art keywords
burn
treatment
cream
wound
burn cream
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201811284828.9A
Other languages
Chinese (zh)
Inventor
王政峰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zhengning Hospital Of Traditional Chinese Medicine
Original Assignee
Zhengning Hospital Of Traditional Chinese Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zhengning Hospital Of Traditional Chinese Medicine filed Critical Zhengning Hospital Of Traditional Chinese Medicine
Priority to CN201811284828.9A priority Critical patent/CN109223931A/en
Publication of CN109223931A publication Critical patent/CN109223931A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/28—Mercury; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
    • A61K36/195—Strobilanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315—Isatis, e.g. Dyer's woad
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/90—Plate chromatography, e.g. thin layer or paper chromatography

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention belongs to drug preparation technique fields, disclose a kind of burn cream and preparation method thereof for treating burn, treat the main component and composition quality of the burn cream of burn are as follows: indigo naturalis 5g, Asian puccoon 4g, dragon's blood 1g, borneol 0.4g, calomel mercurous chloride 0.2g, vaseline 80g.Burn cream treatment burn provided by the invention is without surgery skin grafting, and more other treatment methods are superior, and disability rate is low, and expense is low, ward requires low, the energy early protection surface of a wound, reduction diffusate, to reduce the chance of occurrence of shock；With it is clearing heat and detoxicating, hold back wound detoxification, putrefaction-removing granulation-promoting, activating microcirculation and removing stasis medicinal, swelling and pain relieving function；Reduce dressing change frequency, when reducing the pain, especially dressing of patient to the surface of a wound damage again and the damage on skin island, in favor of skin regeneration；Dressing is convenient, and pain is small, carries out dressing to the surface of a wound for having secretion under scab, without whole large area dressings；Surgery skin grafting treatment is avoided to deep burn；Especially there is apparent anastalsis to the surface of a wound of the easy bleeding of surface of a wound dressing.

Description

A kind of burn cream and preparation method thereof for treating burn
Technical field
The invention belongs to drug preparation technique field more particularly to a kind of burn cream and preparation method thereof for treating burn.
Background technique
Currently, the prior art commonly used in the trade be such that with clinically to pathologic change mechanism understanding by Deeply, there has also been corresponding progress in terms for the treatment of for step.The past traditional treatment viewpoint is more popular for many years because being influenced by condition Early stage conservative observation, is created through repeated multiple times expansions, therefore is inevitably damaged again and secondary infection, exudation etc., and the course for the treatment of is long, dressing is painful, The conditions such as medical expense is high are limited, and find that diffusate is more, tissue necrosis is small in burnt degree 72 through this seminar Recent study When it is interior especially rapidly, therefore introduce the concept of " Disease outbreake ", and gradually received by clinician, but for this reparation Mode, debridement are a great problems, and thorough debridement will cut off all necrotic tissues, it is possible to a part of portion's viability tissue is sacrificed, and It loses many vital tissue structures (Ru Pidao) and leaves the surface of a wound of devitalized tissue if debridement is not thorough, the early stage surface of a wound oozes out in addition Excessively, subinfection again is easily caused.
In conclusion problem of the existing technology is: burnt degree diffusate is more, tissue necrosis is in burnt degree 72 hours Especially rapidly, debridement is a great problem, and thorough debridement will cut off all necrotic tissues, it is possible to sacrifice a part of portion's survival group It knits, and loses many vital tissue structures, if debridement is not thorough, leave the surface of a wound of devitalized tissue, the early stage surface of a wound oozed out in addition It is more, easily cause subinfection again.
Solve the difficulty and meaning of above-mentioned technical problem:
Burn cream of the present invention succeed in developing for treatment burn provide a kind of curative for effect, Small side effects, medicine source extensively, Cheap, easy to use, portable form of Chinese drug, is particularly suitable for basic hospital, opens up for traditional Chinese medicine treatment burn One new approach is expected to become treatment burns novel effective tcm product, and application prospect is extensive.Remove surface of a wound necrosis group It knits and (wipes out blister and the free tissue of skin).Observation group is applied with burn powder or burn cream, with a thickness of 1~2mm, ties within 24~37 hours Scab goes scab debridement to be applied with burn powder or burn cream, intravenous applications antibiotic 3-7 days again if having secretion under scab；If under scab No secretion is then not necessarily to dressing, to voluntarily decrustation.To the stemness surface of a wound (eschar or necrosis incrustation), ointment for external application for curing burn after debridement, to Thorough debridement after molten scab, or scab, debridement are gone using cutting scab and nibbling sample, it is applied with burn powder again.Dressing change frequency is indefinite, and few person is primary , most more than ten times, fully recover, be not necessarily to surgery skin grafting, be all made of exposure method.Debridement number is reduced, and is changed without large area Medicine, to reduce the damage to skin island.
Summary of the invention
In view of the problems of the existing technology, the present invention provides a kind of burn cream and preparation method thereof for treating burn.
The invention is realized in this way a kind of burn cream for treating burn is by indigo naturalis 5g, Asian puccoon 4g, dragon's blood 1g, borneol 0.4g, calomel mercurous chloride 0.2g and vaseline 80g composition.
Another object of the present invention is to provide the preparation method of the burn cream for the treatment of burn, this method are as follows:
Step 1: taking the first-class Asian puccoon of certain mass, is rinsed well, is dried with tap water, powder poling smalls, crossing 200 mesh Sieve；
Step 2: the dragon's blood, borneol, calomel mercurous chloride of certain mass are ground into superfine end respectively, cross 200 meshes；
Step 3: above-mentioned five tastes drug powder being mixed, co-ground again, with dry high temperature sterilization into and disinfection, It is fitted into the plastic bottle of the netted bottleneck of 100 mesh, every bottle of 50g is spare；
Step 4: taking the vaseline of certain mass to be heated to 80 DEG C, and when temperature is down to 50 DEG C, the above mixed-powder is added Enter, 800~1000g of raw medicine powder is added in every 100g vaseline, boil about 10 minutes to obtain the final product with mild fire after mixing, is fitted into modeling pipe It is spare, every pipe 50g.
Another object of the present invention is to provide the detection method of the burn cream for the treatment of burn, this method are as follows:
Step 1: taking burn cream 10g, adds ethyl alcohol 30ml, and setting stirring in water-bath makes to dissolve, and lets cool filtration, removes solidification Vaseline simultaneously filters, and filtrate is evaporated, and 60-90 DEG C of petroleum ether 20ml is added into residue, is ultrasonically treated 20 minutes, filters, filter Liquid is concentrated into 1ml as test solution；
Step 2: Asian puccoon control medicinal material 0.5g separately is taken, control medicinal material solution is made by the same method；
Step 3: it is tested using according to thin-layered chromatography, draws two kinds of each 4ul of solution, put respectively in same silica gel g thin-layer plate On, using thiacyclohexane dimethylbenzene-acetic ether-methanoic acid as solvent, it is unfolded, takes out, dries；
Step 4: in sample chromatogram, on position corresponding with reference medicine chromatography, identical aubergine spot is shown； It is sprayed again with 10% potassium hydroxide methanol solution, spot becomes blue.
Further, the use ratio of the solvent thiacyclohexane dimethylbenzene-acetic ether-methanoic acid are as follows: 5 ﹕, 5 ﹕, 0.5 ﹕ 0.1.
Further, another detection method of the burn cream of the treatment burn are as follows:
Step 1: taking burn cream 10g, adds ethyl alcohol 30ml, and setting stirring in water-bath makes to dissolve, and lets cool filtration, removes solidification Vaseline simultaneously filters, and filtrate is evaporated, and ether 10ml is added into residue, and close plug shakes 10 minutes, and filtration takes filtrate to make for examination Product solution；
Step 2: dragon's blood control medicinal material 0.1g separately is taken, control medicinal material solution is made by the same method；
Step 3: testing using according to thin-layered chromatography, draws test solution, dracorhodin under control medicinal material solution and item, Each 10-20ul of perchlorate reference substance solution puts respectively on same silica gel g thin-layer plate, is expansion with chloroform-methanol Agent is unfolded, takes out, dries；
Step 4: in sample chromatogram, on position corresponding with reference medicine chromatography, identical orange colored spots are shown.
Further, the use ratio of the solvent chloroform-methanol are as follows: 19 ﹕ 1.
In conclusion advantages of the present invention and good effect are as follows:
Having for burn cream provided by the invention is clearing heat and detoxicating, holds back wound detoxification, putrefaction-removing granulation-promoting, activating microcirculation and removing stasis medicinal, swelling and pain relieving The effect of, all kinds of burn and scalds are cured mainly, stemness burn is applicable in.
Without surgery skin grafting, more other treatment methods are superior, and disability rate is low, take for burn cream treatment burn provided by the invention Low, the energy early protection surface of a wound, reduction diffusate, to reduce the chance of occurrence of shock are required with low, ward；Early stage forms a scab, no Easily form surface of a wound subinfection again, also avoid the chance of cross infection in hospital, have it is clearing heat and detoxicating, hold back wound detoxification, putrefaction-removing granulation-promoting, Activating microcirculation and removing stasis medicinal, swelling and pain relieving function；Reduce dressing change frequency, damaging again to surface of a wound when reducing the pain, especially dressing of patient The damage on wound and skin island, in favor of skin regeneration；Dressing is convenient, and pain is small, carries out dressing to the surface of a wound for having secretion under scab, Without whole large area dressings；Surgery skin grafting treatment is avoided to deep burn；The substantially reduced financial burden of patient；Especially There is apparent anastalsis to the surface of a wound of the easy bleeding of surface of a wound dressing.
Burn cream provided by the invention is suitble to external application for curing that tissue of burn necrosis progrediens, easy-clear is not thoroughly sick Change, the clinical characters more than early stage diffusate can make the above problem be readily solved, to keep burns therapeutic effect simply square Just, the early protection surface of a wound reduces exudation and bleeding, further tends to perfect, main pathogenic bacteria golden yellow of the medicine to burns Staphylococcus, pseudomonas aeruginosa have different degrees of bacteriostasis.This is burn cream, the clinical application of burn powder provides Reliable pharmacodynamics foundation.
Detailed description of the invention
Fig. 1 is the preparation method flow chart of the burn cream for the treatment of burn provided in an embodiment of the present invention；
Fig. 2 is the discrimination method flow chart of the burn cream for the treatment of burn provided in an embodiment of the present invention；
Fig. 3 is another discrimination method flow chart of the burn cream for the treatment of burn provided in an embodiment of the present invention.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to embodiments, to the present invention It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to Limit the present invention.
Application principle of the invention is described in detail with reference to the accompanying drawing.
The burn cream for the treatment of burn provided in an embodiment of the present invention is by indigo naturalis 5g, Asian puccoon 4g, dragon's blood 1g, borneol 0.4g, light Powder 0.2g and vaseline 80g composition.
As shown in Figure 1, it is provided in an embodiment of the present invention treatment burn burn cream the preparation method comprises the following steps:
S101: taking the first-class Asian puccoon of certain mass, is rinsed well, is dried with tap water, powder poling smalls, crossing 200 meshes；
S102: the dragon's blood, borneol, calomel mercurous chloride of certain mass are ground into superfine end respectively, cross 200 meshes；
S103: above-mentioned five tastes drug powder being mixed, co-ground again, with dry high temperature sterilization into and disinfection, dress In the plastic bottle for entering the netted bottleneck of 100 mesh, every bottle of 50g is spare；
S104: taking the vaseline of certain mass to be heated to 80 DEG C, and when temperature is down to 50 DEG C, the above mixed-powder is added Enter, 800~1000g of raw medicine powder is added in every 100g vaseline, boil about 10 minutes to obtain the final product with mild fire after mixing, is fitted into modeling pipe It is spare, every pipe 50g.
As shown in Fig. 2, the discrimination method of the burn cream for the treatment of burn provided in an embodiment of the present invention are as follows:
S201: taking burn cream 10g, adds ethyl alcohol 30ml, and setting stirring in water-bath makes to dissolve, and lets cool filtration, removes all of solidification Intellectual circle simultaneously filters, and filtrate is evaporated, and 60-90 DEG C of petroleum ether 20ml is added into residue, is ultrasonically treated 20 minutes, filtration, filtrate 1ml is concentrated into as test solution；
S202: Asian puccoon control medicinal material 0.5g separately is taken, control medicinal material solution is made by the same method；
S203: it is tested using according to thin-layered chromatography, draws two kinds of each 4ul of solution, put respectively in same silica gel g thin-layer plate On, using thiacyclohexane dimethylbenzene-acetic ether-methanoic acid as solvent, it is unfolded, takes out, dries；
S204: in sample chromatogram, on position corresponding with reference medicine chromatography, identical aubergine spot is shown；Again With 10% potassium hydroxide methanol solution, spot becomes blue for spray.
The use ratio of solvent thiacyclohexane dimethylbenzene-acetic ether-methanoic acid provided in an embodiment of the present invention are as follows: 5 ﹕, 5 ﹕ 0.5 ﹕ 0.1.
Prescription, effect and the modern pharmacological research of burn powder of the invention
Composition: indigo naturalis, Asian puccoon, dragon's blood, borneol, calomel mercurous chloride.
Preparation formulation: burn powder, above-mentioned five kinds of medicines are smalls altogether, cross 200 mesh, and bottling mouth is that netted bottle is spare；Burn cream, Ointment is made by burn powder and vaseline etc., is bottled spare.
Effect: it is clearing heat and detoxicating, hold back wound detoxification, putrefaction-removing granulation-promoting, activating microcirculation and removing stasis medicinal, swelling and pain relieving.
Fang Xie: indigo naturalis has the benefits of clearing heat and detoxicating, hemostasis, activating blood circulation and reducing swelling in side；Asian puccoon has clearing heat and cooling blood, activating blood circulation and reducing swelling, solution The benefits of malicious sore；Dragon's blood has the benefits of promoting blood circulation analgesic therapy, removing blood stasis and hemostasis, expelling pus and promoting granulation；There is borneol clearing away heat to and alleviating pain, erosion prevention and muscle growing to make With；Calomel mercurous chloride external application has the benefits of detoxicating and destroying parasites, sore, and taking orally has sharp water defaecation, there is stronger detoxicating and destroying parasites, antipruritic and myogenic Sore effect.All medicines are harmonious, play altogether it is clearing heat and detoxicating, hold back wound detoxification, putrefaction-removing granulation-promoting, activating microcirculation and removing stasis medicinal, swelling and pain relieving function.
Indigo naturalis is acanthaceous vegetable acanthaceous indigo (baphicacanthns cusia cneesbremek), polygonaceae plant indigo plant The leaf or stem of (polygonmm tinclorinm hit) or cruciferae isatis (isatis indigotica fort) Dried powder made of leaf is processed or agglomerate.This taste is salty, cold in nature, has clearing heat and detoxicating, the clear spot of cool blood, clearing liver-fire, determines Frightened function, is one of conventional Chinese medicine, and " Prescriptions for Universal Relief " is recorded, for controlling the pathogenic fire,toxin and furuncles of excessive noxious heat, can be ground altogether with gypsum rubrum For end, it is applied with affected part, such as green gold dissipates.Modern pharmacology proves that indigo naturalis has a variety of pharmacological activity such as anticancer, antibacterial, liver protection.Mainly contain Indigo, green fixed palm fibre, malic acid, cupreol, protein and a large amount of inorganic salts etc..Pharmacology related with treatment burn has: anti- Inflammation, " Bencao Jingshu " call this product: " removing toxic substances removes heat, because of its chief ...." this product is clearing heat and detoxicating, effect and its resisting pathogenic microbes Act on related, there is certain antibacterial action, in vitro test indigo naturalis to staphylococcus aureus, bacillus anthracis, Shigella shigae, Comma bacillus has antibacterial action, is consistent with heat-clearing toxin-expelling functions.
Asian puccoon is comfrey lithospermum euchromum Royle [ameabia enchroma (royle)
Johnst], Asian puccoon (lrthosperonm erythrorhizon sieb etzna) or interior Ying Asian puccoon (gnttatabnnge) dry root.It is cold in nature, it is sweet in flavor, salty, there is clearing heat and cooling blood, promoting blood circulation, removing toxic substances promoting eruption and other effects, clinically Belong to conventional Chinese medicine.For treating warm disease blood-heat and toxin exuberance, atropurpureus macula, measles without adequate eruption, sore, eczema, scald etc..Asian puccoon Effective ingredient be it is a variety of how Quinone Pigments (shikonin), alkannan, Acetylshikonin, deoxyshikonin, isobutyryl shikonin, two First amylene acyl alkannin, beta-dimethyl acryloyl alkannin etc., related pharmacology has with treatment burn: 1. resisting pathogenic microbes, Asian puccoon water, alcohol and oil solution have obvious inhibiting effect to a variety of pathogenetic bacterias, such as proteus, hemolytic streptococcus, golden yellow Staphylococcus, Pseudomonas aeruginosa, Escherichia coli, shigella dysenteriae etc., Asian puccoon antibacterial effective ingredient be how naphtoquinone compounds, also have antiviral Effect, antivirus action are that it is inhibited to replicate in host cell.2. anti-inflammatory and antiallergy, a variety of how Quinone Pigments have wide spectrum Bioactivity and pharmacological activity be one of anti-inflammatory effective ingredient.Acetylshikonin takes off gastral cavity injection to rat skin caused by histamine Thin vasopermeability increase has inhibiting effect, research shows that the anti-inflammatory mechanisms of alkannin may be with inhibition arachidonic acid rouge oxygen phenol It is metabolized related.For Asian puccoon there are also significant anti-allergic effects, the stomach-filling of Asian puccoon decocting liquid can fight lethal dose horse serum and lethal dose Lethal effect of the histamine to rabbit.Lithosperman can significantly inhibit delayed allergy.3. it is antipyretic, although Asian puccoon cannot prevent Body temperature increases, but can inspire pyretolysis.Studies have shown that rabbit experiment caused by intramuscular injection milk is sent out in the stomach-filling of Asian puccoon decocting liquid Heat has the refrigeration function of mitigation.4. having apparent anastalsis, pharmacological research shows six kinds of Asian puccoon aqueous extracts and alcohol extract 10mg/Kg is gavaged continuous 3 days, has different degrees of anastalsis to mouse docking bleeding, solidifying to rat caused by heparin The blood time extends, and intraperitoneal injection alkannin 10mg/Kg, Acetylshikonin 10mg/Kg can be such that recalcification time is obviously shortened.
Dragon's blood is the red tree oozed out in babassu kylin dragon's blood (DaemcnropsdracoBL) fruit and trunk Rouge, this product sweet-salty, mild-natured, return liver warp have promoting blood circulation analgesic therapy, removing blood stasis and hemostasis, the function for holding back necrotic tissue and promoting muscle growing, are a kind of resin and dragon's blood tree The mixture of rouge tan alcohol, contain dracorhodin, dracorubin, demethyl dracorhodin, demethyl dracorubin and flavanols, chalcone, The compositions such as resin acid, related pharmacology has with treatment burn: 1. stagnation resolvation, hemostasis, analgesic, " Compendium of Materia Medica Sanguis Draxonis " are said: " being dissipated The stagnant all pains of blood, married woman's vim and vigour ...." no matter the new old wound of the stasis of blood is all suitable, it is suitable for various blood stasis and swelling pains.In rabbit vein bypass circuit In experimental method, dragon's blood can significantly shorten bleeding time, clotting time and thrombin time, inhibition thrombosis.Whole blood can be reduced And plasma viscosity, hematocrit is reduced, electrophoretic velocity of the red blood cell in direct current field is accelerated.2. myogenic sore " is newly repaired Book on Chinese herbal medicine " " main the five internal organs perverse trend, leukorrhagia is pained, breaks hematocele, gold creation meat for meaning dragon's blood." this product outside hold back by the good hemostasia and promoting granulation of apparatus Sore effect, applies to the diseases such as traumatic hemorrhage, unhealing ulcer, and in addition there are anti-inflammatory and antalgic, resisting pathogenic microbes, inhibition fungies etc. to make With.Scalding model mouse is treated with 906 burn cream of dragon's blood system, none infection of 906 burn cream treatment group mouse, control group Mouse is all infected with Pseudomonas aeruginosa, the hemostasis of modern mostly application various Medicine and Surgery and the treatment of trauma infection contamination.
Borneol is Spore density kapur (Dryobatan ops aromatica CaertnF) resin processed goods, Or trunk, the branch chopping of borneo camphor tree claim " longan borneol ", also referred to as " Cape jasmine piece " through crystallizing obtained by distillation cooling.By composite family Processed split of sublimate of plant Blumea balsamifera leaf (great Ai) (BLemeabals amifera DC) is cut, and is claimed " L-Borneol ".It is now more It with turpentine oil, camphor etc., is chemically synthesized, is claimed " BORNEOLUM SYNTHETICUM ".Borneol (barnEOL) containing d-Bomeol, and contain The sequiterpenes such as beta-elemene, carypohyllene and oleanolic acid etc..L-Borneol contains L-Borneol.BORNEOLUM SYNTHETICUM is with racemization mixing borneol. Borneol acrid flavour, hardship, cold nature have the effect of inducing resuscitation of having one's ideas straightened out, clearing away heat to and alleviating pain.Pharmacology related with treatment burns has: " medical center Bun is wanted ": " borneol master dissipate stagnated fire, can deep heat, control swollen frightened epilepsy, phlegm confusing heart, sore throat, tongue, toothache, deafness, breath, hot eyes, acne it is malicious in Fall into, desinsection, hemorrhoid, expedite the emergence of, property is walked without keeping, also can myogenic pain.It so dissipates and easily exhausts, be cold sensation of the genitalia after all." borneol part is just There is minimal irritation with to sensory nerve, has certain analgesic and mild antisepsis, higher concentration (0.5%) is to grape ball Bacterium, streptococcus, Diplococcus pneumopniae, the pathogenic dermatophyte of Escherichia coli and part etc. have inhibiting effect.Extracorporeal bacteria inhibitor test card Bright, borneol, isoborneol have antibacterial action, and synthetic borneol and natural borneol have identical bacteriostasis.In addition borneol is applied alone Or a variety of surgical infection inflammation of external preparation external application for curing are made with indigo naturalis etc., such as shingles zoster, erysipelas, acute mastitis, bee Nest tissue inflammation etc..This product has clearing heat and detoxicating, erosion prevention and muscle growing to act on, therefore external application clearing heat for detumescence, myogenic sore, treatment sore swell and ache curative, The diseases such as unhealing ulcer, ruptured abscess resistant to healing, scald.
Calomel mercurous chloride is the calogreen (Hg made of sublimed method such as mercury, alum (or blue stone), salt2CL2) crystallinity powder End.Acrid flavour, it is cold in nature, it is toxic.External application detoxicating and destroying parasites, sore, defaecation for oral administration of relieving oedema or abdominal distension through diuresis or purgation.External application control sore, fester, scabies disturb and itch, is wet Rash, brandy nose, syphilitic chancre etc., this product is pungent to tremble with fear dry strong, there is stronger detoxicating and destroying parasites, the effect of antipruritic and myogenic sore.Calomel mercurous chloride has Broad-spectrum antibacterial effect has good fungistatic effect to a variety of Grain-positives and negative bacterium and pathogenic dermatophyte.It is burnt with treatment Sick and wounded related pharmacology has: antibacterial anti-inflammatory, myogenic sore, wound healing.
In order to fully ensure that this quality, it is ensured that clinical efficacy is stablized, and seminar has carried out galenic pharmacy research, including production Technique, quality standard are formulated.The production technology of burn powder is that the medicines such as indigo naturalis, Asian puccoon, dragon's blood, borneol, calomel mercurous chloride are ground superfine end altogether, 200 meshes are crossed, it is spare to fill netted mouth plastic bottle for dry high-temperature sterilization.Burn cream is with burn powder and vaseline, heated mixing To obtain the final product.Process flow is scientific and reasonable, ensure that active constituent content.It includes prescription, system that burn powder, burn extractive quality standard, which are formulated, Method, character, identification, inspection, assay, usage and dosage, storage etc..This standard presses " Chinese Pharmacopoeia " external preparation Pertinent regulations are formulated.
Indigo naturalis 5g, Asian puccoon 4g, dragon's blood 1g, borneol 0.4g, calomel mercurous chloride 0.2g, vaseline 80g (5:4:1:0.4:0.2) burn cream Medicine-feeding: 80
Preparation process:
Burn cream: taking vaseline to be heated to 80 DEG C, when temperature is down to 50 DEG C, the burn powder prepared is added, often 100g vaseline adds 800~1000g of raw medicine, boils about 10 minutes to obtain the final product with mild fire after mixing, is fitted into spare, every pipe in modeling pipe 50g。
Illustrate:
1. Asian puccoon selects to choose when medicine Deng Asian puccoons, impurity is removed, rinses dust, unsuitable foam washing overlong time, in order to avoid lose Effective ingredient.
2. borneol, calomel mercurous chloride be volatile to lose fragranced, therefore closed preservation.
Easy carbon when 3. indigo naturalis, Asian puccoon meet high oil temperature, easily lose effectively at therefore while preparing controls oil temperature.
4. every gram is equivalent to 1.1 grams of crude drug in whole with finished product prepared by this technique.
As shown in figure 3, another discrimination method of the burn cream for the treatment of burn provided in an embodiment of the present invention are as follows:
S301: taking burn cream 10g, adds ethyl alcohol 30ml, and setting stirring in water-bath makes to dissolve, and lets cool filtration, removes all of solidification Intellectual circle simultaneously filters, and filtrate is evaporated, and ether 10ml is added into residue, and close plug shakes 10 minutes, and filtration takes filtrate to make test sample Solution；
S302: dragon's blood control medicinal material 0.1g separately is taken, control medicinal material solution is made by the same method；
S303: testing using according to thin-layered chromatography, draws test solution, dracorhodin, height under control medicinal material solution and item Each 10-20ul of chlorate reference substance solution is put respectively on same silica gel g thin-layer plate, using chloroform-methanol as solvent, It is unfolded, take out, dries；
S304: in sample chromatogram, on position corresponding with reference medicine chromatography, identical orange colored spots are shown.
The use ratio of solvent chloroform-methanol provided in an embodiment of the present invention are as follows: 19 ﹕ 1.
The invention will be further described combined with specific embodiments below.
Observe the Clinical efficacy and safety evaluation of burn cream treatment burn
270 patients are randomly divided into control group 90 and observation group 180.Two groups are taken Primary Care, debridement, resisted Infection, using antibiotic, fluid infusion, supportive treatment.Observation group is applied with burn powder and burn cream in addition to Primary Care.Control group removes Outside Primary Care, it is applied with moist exposed burn cream.As a result observation group is in curative effect, treatment number of days, rear scar, the course of disease and treatment by upper There are significant difference (P < 0.05) with control group, and observation group is better than control group as the result is shown.Conclusion burn cream/dissipate and can be obviously improved The clinical symptoms and sign of fire victim.
Moist exposed burn cream ShinunShaoshangGao, standard: State Food and Drug Administration's national drug is executed Standard (new drug become a full member standard) the 40th WS3-043 (Z-005) -2002 (Z), authentication code: national drug standard Z20000004, life Produce enterprise: Shantou Mebo Pharmaceuticals Co., Ltd..
It is observed through clinical control, treats burns with burn powder, total effective rate is substantially better than control group, especially observation group The exudation of middle burn wound less, not easy infection, the fast early protection surface of a wound of incrustation, without skin-grafting, healing time is short.
The usage and dosage of burn cream provided by the invention are as follows: surface of a wound external application.Appropriate this product is taken to be applied to affected part, according to surface of a wound feelings Condition is applied with, and number is indefinite, applies thickness medicine 1mm.
The points for attention of burn cream provided by the invention are as follows:
This product is very fast using the incrustation of the rear surface of a wound, notices that whether there is or not secretion under scab, and scab, cleaning is then needed to change if any secretion Medicine is applied with again
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention Made any modifications, equivalent replacements, and improvements etc., should all be included in the protection scope of the present invention within mind and principle.

Claims (6)

1. a kind of burn cream for treating burn, which is characterized in that the burn cream of the treatment burn is by indigo naturalis 5g, Asian puccoon 4g, blood Exhaust 1g, borneol 0.4g, calomel mercurous chloride 0.2g and vaseline 80g composition.
2. a kind of preparation method of the burn cream of the burn for the treatment of as described in claim 1, which is characterized in that the treatment burn Burn cream the preparation method comprises the following steps:
Step 1: taking the first-class Asian puccoon of certain mass, is rinsed well, is dried with tap water, powder poling smalls, crossing 200 meshes；
Step 2: the dragon's blood, borneol, calomel mercurous chloride of certain mass are ground into superfine end respectively, cross 200 meshes；
Step 3: above-mentioned five tastes drug powder being mixed, co-ground again, with dry high temperature sterilization into and disinfection, be packed into In the plastic bottle of the netted bottleneck of 100 mesh, every bottle of 50g is spare；
Step 4: taking the vaseline of certain mass to be heated to 80 DEG C, and when temperature is down to 50 DEG C, the above mixed-powder is added, Add 800~1000g of raw medicine powder in every 100g vaseline, boil about 10 minutes to obtain the final product with mild fire after mixing, is packed into modeling Guan Zhongbei With every pipe 50g.
3. a kind of detection method of the burn cream for the treatment of burn as described in claim 1, which is characterized in that the treatment burn Burn cream detection method are as follows:
Step 1: taking burn cream 10g, adds ethyl alcohol 30ml, and setting stirring in water-bath makes to dissolve, and lets cool filtration, removes all scholars of solidification Woods simultaneously filters, and filtrate is evaporated, and 60-90 DEG C of petroleum ether 20ml is added into residue, is ultrasonically treated 20 minutes, filtration, and filtrate is dense 1ml is reduced to as test solution；
Step 2: Asian puccoon control medicinal material 0.5g separately is taken, control medicinal material solution is made by the same method；
Step 3: testing using according to thin-layered chromatography, draw two kinds of each 4ul of solution, is put respectively on same silica gel g thin-layer plate, Using thiacyclohexane dimethylbenzene-acetic ether-methanoic acid as solvent, it is unfolded, takes out, dries；
Step 4: in sample chromatogram, on position corresponding with reference medicine chromatography, identical aubergine spot is shown；It sprays again With 10% potassium hydroxide methanol solution, spot becomes blue.
4. the detection method of the burn cream for the treatment of burn as claimed in claim 3, which is characterized in that the solvent thiacyclohexane Dimethylbenzene-acetic ether-methanoic acid use ratio are as follows: 5 ﹕, 5 ﹕, 0.5 ﹕ 0.1.
5. a kind of detection method of the burn cream for the treatment of burn as described in claim 1, which is characterized in that the treatment burn The detection method of burn cream include:
Step 1: taking burn cream 10g, adds ethyl alcohol 30ml, and setting stirring in water-bath makes to dissolve, and lets cool filtration, removes all scholars of solidification Woods simultaneously filters, and filtrate is evaporated, and ether 10ml is added into residue, and close plug shakes 10 minutes, and filtration takes filtrate to make test sample molten Liquid；
Step 2: dragon's blood control medicinal material 0.1g separately is taken, control medicinal material solution is made by the same method；
Step 3: testing using according to thin-layered chromatography, draws test solution, dracorhodin, high chlorine under control medicinal material solution and item Each 10-20ul of hydrochlorate reference substance solution puts respectively on same silica gel g thin-layer plate, using chloroform-methanol as solvent, opens up It opens, take out, dry；
Step 4: in sample chromatogram, on position corresponding with reference medicine chromatography, identical orange colored spots are shown.
6. the detection method of the burn cream for the treatment of burn as claimed in claim 5, which is characterized in that three chloromethane of solvent Alkane-methanol use ratio are as follows: 19 ﹕ 1.
CN201811284828.9A 2018-10-31 2018-10-31 A kind of burn cream and preparation method thereof for treating burn Pending CN109223931A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811284828.9A CN109223931A (en) 2018-10-31 2018-10-31 A kind of burn cream and preparation method thereof for treating burn

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201811284828.9A CN109223931A (en) 2018-10-31 2018-10-31 A kind of burn cream and preparation method thereof for treating burn

Publications (1)

Publication Number Publication Date
CN109223931A true CN109223931A (en) 2019-01-18

Family

ID=65079756

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201811284828.9A Pending CN109223931A (en) 2018-10-31 2018-10-31 A kind of burn cream and preparation method thereof for treating burn

Country Status (1)

Country Link
CN (1) CN109223931A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115015431A (en) * 2022-06-24 2022-09-06 汕头市美宝制药有限公司 Quality control method for poppy capsule in Chinese medicinal preparation

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115015431A (en) * 2022-06-24 2022-09-06 汕头市美宝制药有限公司 Quality control method for poppy capsule in Chinese medicinal preparation
CN115015431B (en) * 2022-06-24 2024-05-17 汕头市美宝制药有限公司 Quality control method for poppy shell component in Chinese medicinal preparation

Similar Documents

Publication Publication Date Title
US11571452B2 (en) Method of treating a skin wound with a liquid-state topical pharmaceutical composition
CN101310748B (en) Ointment for treating empyrosis
CN104288504B (en) A kind of Chinese medicine ointment formulation for treating burn, scald and preparation method thereof
CN105362295A (en) Periplaneta americana pharmaceutical composition for treating acute and chronic faucitis and dental ulcers and preparation method thereof
CN101703651B (en) Medicament for treating diabetic gangrene
CN103007000A (en) New medicine for treating burns and wounds and preparation method thereof
CN109223931A (en) A kind of burn cream and preparation method thereof for treating burn
CN103263451B (en) Traditional Chinese medicine for mainly treating trauma as well as sore and ulcer, preparation method and application of traditional Chinese medicine
CN105560620A (en) Trauma treatment traditional Chinese medicine preparation
CN1385193A (en) Traditional Chinese medicine having effects of reducing inflammation, stopping blooding, stopping pain, promoting blood circulation and promoting tissue regeneration
CN102743587A (en) External application wound repair liquid
CN110624032A (en) Ointment for treating burns and scalds and preparation method thereof
CN109172714A (en) A kind of burn powder and preparation method thereof
CN113813308A (en) Medicine for treating burn and scald and preparation method thereof
CN109045204A (en) A kind of herb liquid and preparation method thereof for treating burn and scald
CN116036168B (en) Traditional Chinese medicine composition for treating phlebitis and application thereof
CN114931611B (en) A Chinese medicinal composition for treating burn, scald and wound, and its preparation method
TW201309317A (en) An extract of plant providing for treating the healing of wounds
CN1456178A (en) External applied medicine for curing burn and preparing method thereof
CN102423383A (en) Powder for removing slough and promoting tissue regeneration
CN107095884A (en) A kind of Eradicates necrotic tissue and promoting muscle growings cream
CN105617273A (en) Pharmaceutic preparation for promoting wound healing and application thereof
CN1262300C (en) Medicinal liquid for Hong Kong foot
CN108245577B (en) Ointment for relieving pain, eliminating swelling and promoting tissue regeneration of burn and preparation method thereof
CN116898932A (en) External wound medicine and preparation method thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20190118

RJ01 Rejection of invention patent application after publication