KR101374537B1 - Pharmaceutical Composition for Burn Treatment Using Gombo-Baechu - Google Patents

Abstract

The present invention is the extract of Morel cabbage, Bupleurum falcatum L. extract and Peony ( Paeonia Disclosed is a pharmaceutical composition for burn treatment, characterized in that it contains lactiflora Pall.) extract.

Description

Pharmaceutical Composition for Burn Treatment Using Gombo-Baechu}

The present invention relates to a pharmaceutical composition for treating burns, and more particularly, to a pharmaceutical composition for treating burns using bark cabbage.

Morel cabbage is a perennial herb with nectar and is also called yeonseolcho, cheongwacho, mamacho, dongdongcheong, and cats. It is said that it looks like a bear. It has a vivid scent from the outpost of Morel cabbage, its taste is hot and bitter, and its properties are cool and nonpoisonous. In addition to flavonoids, homoplanetaminin, hispiduline, eucaponolin, eucaponolin-7-glucoside, phenolic substances, essential oils, saponins, cardiac glycosides, unsaturated fatty acids, etc. Anti-viral, anti-allergic and anti-inflammatory effects, such as bronchitis, seawater, asthma, lung diseases, gynecological diseases, blood pressure, diabetes, atopic dermatitis, etc. are effective.

Seaple ( Bupleurum falcatum L.) belongs to the apiaceae family, wild in mountains, foothills and fields all over Korea. The components include a mixture of saikosaponin, alpha-spinasterol, stigmasterol, etc. It has the effects of stabilizing, anti-allergic, liver function-enhancing, increasing cellular immune and humoral immunity, inhibiting the epidemic cold cause, fever, analgesic, sedative.

Paeonia lactiflora Pall.) is a perennial herb belonging to the peony family and is cultivated everywhere in China, Japan and Korea. Main ingredients include benzoic acid (benzoic acid, antibacterial action, preservative), asparin (metabolism amino acid), sterin (metabolism), salicylic acid (antipyretic action, antiseptic action). Lowering fever to the body, fever, immune function control, anti-inflammatory, anti-inflammatory antipyretic effect is effective.

Burns are mainly caused by accidents, and may be classified into burns by heat, burns by electric current, burns by chemical substances, burns by radiation, and the like, depending on the cause. The severity of the burn is divided into 1st, 2nd, 3rd, and 4th degree burns, depending on the width, depth of the burn, the temperature and contact time of the object that caused the burn, and the condition of the skin. And require hospital treatment.

First-degree burns are accompanied by pain such as reddening of the skin and tingling. It causes damage to the epidermis, the outermost layer of the skin, and swells with pain and erythema. The symptoms disappear in a few days, but there may be a slight fallout and pigmentation in place. No scars remain after recovery. Sun burn is an example of the most common first degree burns.

Second-degree burns affect both the epidermis and the dermis, causing erythema, pain, edema, and blistering within 24 hours of the accident. This burn also affects the gland and pores. Awakening is burning and painful. When the blisters burst, they show erosions and a large amount of secretion. Special care should be taken when the burned area reaches more than about 15% of the body surface area. Heals within a few weeks, but pigmentation and discoloration often remain in place. The secondary infection causes more local symptoms and lasts longer.

Third-degree burns affect the epidermis, dermis, and hypodermis, resulting in darkening or translucent whitening of the skin and clotting of blood vessels just below the surface of the skin. The burn may become numb, but the patient feels extreme pain, necrosis of the skin tissue and structure, which takes a lot of time to heal and scars. Two weeks after the accident, the scab peels off and the ulcer surface appears. There is a lot of secretion and easy to bleed, but gradually new tissue develops, the epidermis regenerates, leaving scars and healing. In cases of deep skin necrosis, or secondary infections, healing may be delayed and the surface of the scar may become irregular, resulting in keloids, deformations, or movement disorders. Special care should be taken when the burned area covers more than 10% of the body surface area.

A fourth degree burn is a case where the burned area tissue is carbonized and turned black, and a fat burn, ligament, fascia, muscle, and bone tissue located under the skin layer is burned. It occurs mainly in high-voltage electrical burns, and can sometimes occur when fungal infections occur in deep 2-3 degree burns. If the range of burn is more than 20%, a systemic body reaction may occur, such as low blood pressure, shock, acute renal failure due to excessive fluid loss, and later wound infection, pneumonia, sepsis, multiple organ failure syndrome, etc. This happens too.

For the treatment of burns, it is important to heal the initial burn wounds or reduce the burn site as soon as possible. In early burn wound dressings, emphasis is placed on early treatments to control infection and inflammation, to maintain a moist environment, to prevent growth into deep burns through the administration of growth factors or cytokines to help skin regeneration, and to use topical heparin.

Given the severity of burn injury, the development of therapeutic agents useful for the treatment or prevention of burn injury will greatly assist in the treatment, condition improvement and scar reduction of burn patients.

Recently, many drug materials using natural products have been developed to reduce human irritation caused by various chemicals. Natural materials not only have fewer side effects on the human body, but as the consumer's response to the drugs using natural materials has increased recently, the development value of natural materials as drug raw materials is increasing.

It is an object of the present invention to provide a pharmaceutical composition for burn treatment composed of natural products, which is harmless to the human body and has excellent safety.

In addition, the present invention has no side effects such as itching when applied to the affected area using a natural product, it is an object of the present invention to provide a pharmaceutical composition for the treatment of burns to cure the pain without scars and excellent skin regeneration ability.

In addition, an object of the present invention is to provide a pharmaceutical composition for burn treatment that can effectively treat burns in a short time.

In order to achieve the above object, the present invention is the extract of Morel cabbage, Bupleurum falcatum L. extract and Peony ( Paeonia It is characterized by a pharmaceutical composition for burn treatment containing lactiflora Pall.) extract.

In addition, the bark cabbage juice in the present invention is characterized in that it is heated at 90 ℃ or less after filtering with a filter of 1㎛.

In the present invention, the shiho extract and peony extract is characterized in that the hydrothermal extract extracted at 130 ℃ after breaking at 120 ℃.

In addition, the present invention is characterized by containing 0.5 ~ 0.99% by weight of the Morel cabbage juice with respect to the whole composition.

Hereinafter, the means for solving the problems of the present invention will be described in detail.

The present invention relates to a pharmaceutical composition for the treatment of burns, by mixing the bark cabbage juice in Shiho extract and peony extract, there is no side effect such as itching when applied to the affected area, pain relief and excellent skin regeneration ability to burn quickly without scar It can be cured.

Morel cabbage juice of the present invention is to grind the raw cabbage and squeeze the raw juice, it is preferable to squeeze the fresh juice after washing the whole to the root that is not dry. In addition, it is preferable to filter the fresh juice with a filter of 1㎛ to remove the precipitate.

In addition, the bark cabbage is heated at a high temperature of more than 90 ℃ unique spicy flavor of fly goes away, this spicy taste is a drug active ingredient, especially above 120 ℃ is destroyed. Therefore, the bark cabbage juice of the present invention is preferably heat sterilized at a low temperature of 90 ℃ or less in order to prevent the destruction of the active ingredient.

In addition, Shiho extract and peony extract of the present invention is preferably extracted at a high speed at 130 ℃ after breaking at 120 ℃ as hot water extract. Extraction in this way can prevent the destruction of the active ingredient of Shiho and peony to the maximum. In addition, Shiho extract and peony extract of the present invention is preferably extracted so that 10ml of components per 100ml of distilled water in order to maximize the effect of the active ingredient.

The pharmaceutical composition for burn treatment of the present invention is made by mixing the morel cabbage juice, Shiho extract and peony extract, it is preferable that the content of morel cabbage juice does not exceed 1% by weight based on the total weight of the composition. If the content of Morel cabbage juice is more than 1% by weight because the burn treatment effect is rather reduced. Preferably 0.5 ~ 0.99% by weight, more than 8 to 12% by weight Shiho extract and 8-12% by weight peony extract, more preferably 0.97% by weight, more than 10% by weight Shiho extract, peony It is preferable to contain 10% by weight of the extract and 79.03% by weight of distilled water.

According to the present invention, it is possible to provide a pharmaceutical composition for burn treatment which is made of natural products and is harmless to the human body and has excellent safety.

In addition, according to the present invention there is no side effect such as itching when applied to the affected area by using a natural product, it can provide a pharmaceutical composition for the treatment of burns that can cure the pain without scars by relieving pain and excellent skin regeneration ability.

In addition, according to the present invention can provide a pharmaceutical composition for burn treatment that can effectively treat the burn in a short time.

In addition, according to the present invention can be formulated in a variety of forms, such as cream-type ointment, liquid spray can provide a pharmaceutical composition for easy burn treatment.

In addition, the present invention can provide a pharmaceutical composition for burn treatment useful when the production method is not complicated and the production cost is low and a large amount of production and a large amount of use are required.

Hereinafter, the present invention will be described in more detail with reference to the following examples, but the scope of the present invention is not limited to the following examples, and includes all modifications of equivalent technical spirit.

Example  1: Preparation of pharmaceutical composition for burn treatment

After washing the whole to the root of the non-Ivy cabbage to dry and squeeze the juice, the juice was filtered with a filter using a filter paper of 1㎛, it was heated at about 90 ℃. Shiho and Peony extract was prepared to contain 10ml of components per 100ml of water. The prepared Morel cabbage juice 0.97% by weight, peony 10% by weight, Shiho 10% by weight, distilled water was mixed in the amount of 79.03% by weight to prepare a pharmaceutical composition for burn treatment.

Example  2: Preparation of pharmaceutical composition for burn treatment

A pharmaceutical composition for burn treatment was prepared in the same manner as in Example 1 except for mixing in an amount of 0.5 wt% of Morel cabbage juice, 10 wt% of peony, 10 wt% of Shiho, and 79.5 wt% of distilled water.

Comparative Example  : Manufacture of pharmaceutical composition for burn treatment

A pharmaceutical composition for burn treatment was prepared in the same manner as in Example 1, except that 1% by weight, more than 10% by weight, peony 10% by weight, and 79% by weight of distilled water were mixed.

Experimental Example  1: skin irritation test

In the present experimental example, the pharmaceutical composition for burn treatment prepared in Examples 1, 2 and Comparative Example was applied to the skin of human arm 1.5 × 1.5cm 2 for 13 days twice a day to examine toxicity and side effects. After 15 days, the skin of the arm to which the pharmaceutical composition for burn treatment prepared in Examples 1, 2 and Comparative Example was applied did not show any abnormality. Therefore, it can be seen that the pharmaceutical composition for burn treatment prepared in Examples 1, 2 and Comparative Examples does not cause toxicity and side effects on human skin.

Experimental Example  2: Animal Experiment on the Effect of Burn Treatment

In this experimental example, the effect of burn treatment on the rats of the pharmaceutical compositions of Examples 1, 2 and Comparative Example was observed.

Six rats were sampled to remove hair from the back or leg and irradiated with UV light to cause second degree burns. The burn treatment compositions of Examples 1, 2 and Comparative Example were applied three times a day to the burned lesions. The surface area of the burn wound was observed for 7 days to evaluate the treatment effect as a change in the surface area of the burn, and the degree of rash after 6 hours after the application of the composition for burn treatment was also observed and the scar remained after the wound was cured. It was. The results are shown in Tables 1 and 2 below. A commercially available burn ointment was used as a control.

Wound surface area (㎠) Water
scar
(When cured) Early After 7 days Reduction amount Example 1 6.1 0.9 5.2 Completely stopped Less than 3.0% Example 2 6.3 1.3 5.0 Completely stopped Less than 3.5% Comparative Example 6.2 3.1 3.1 Little flow 6.0% Control group 6.1 4.1 2.0 flow 30%

Elapsed days Reduction of wound surface area (㎠) Example 1 Example 2 Comparative Example Control group 1 day 2.1 2.6 1.3 0.3 2 days 3.1 3.5 1.5 0.5 3 days 4.3 4.1 1.8 0.8 4 days 4.5 4.3 2.0 1.1 5 days 4.7 4.5 2.4 1.4 6 days 5.0 4.8 2.9 1.7 7 days 5.2 5.0 3.1 2.0

As shown in Tables 1 and 2, the compositions for treating burns of Examples 1 and 2 of the present invention showed superior burn treatment effects as compared to the compositions for treating burns of the comparative example and the control group. In particular, the compositions for burn treatments of Examples 1 and 2 were excellent in skin regeneration ability, and there was almost no scar after cured, and the burn treatment effect appeared immediately and quickly.

Claims (4)

Morel juice, Bupleurum falcatum L.) extract and Paeonia lactiflora Pall. (Pharmaceutical composition for burn treatment) comprising the extract. The method of claim 1,
The morel cabbage juice is filtered with a filter of 1 ㎛, burned pharmaceutical composition, characterized in that heated at 90 ℃ or less. The method of claim 1,
The Shiho extract and peony extract are burned at 120 ° C., and then burn the pharmaceutical composition for burn treatment, characterized in that the hot water extract extracted at 130 ℃. The method of claim 1,
The pharmaceutical composition for burn treatment, characterized in that containing 0.5 ~ 0.99% by weight based on the whole composition.