CN101041014B - Plaster for treating scald and burn for external application - Google Patents
Plaster for treating scald and burn for external application Download PDFInfo
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- CN101041014B CN101041014B CN2007100617317A CN200710061731A CN101041014B CN 101041014 B CN101041014 B CN 101041014B CN 2007100617317 A CN2007100617317 A CN 2007100617317A CN 200710061731 A CN200710061731 A CN 200710061731A CN 101041014 B CN101041014 B CN 101041014B
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- bletillae
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- scald
- burn
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Abstract
The invention provides a film coating agent for treating scalds and burns, wherein the raw material herbs include (by weight ratio) rheum officinale 7-13 parts, calcined gypsum 5-15 parts, bletilla striata 3-10 parts and glycerin 3-6 parts. The invention also discloses the process for preparing the medicinal agent.
Description
Technical field
The present invention relates to a kind of external Chinese patent medicine that is used for the treatment of diseases such as scald, burn, especially a kind of liniment that is used for the treatment of the external Chinese patent medicine of diseases such as scald, burn.
Background technology
The medicine of diseases such as treatment scald, burn is selected medicine for external use such as JINGWANHONG, moist expose burn ointment usually for use at present, treats in conjunction with medicines such as transfusion, antibiotic simultaneously, and treatment time is long, and healing time is long, and patient's tolerance is relatively poor.Wound surface is difficult for nursing after the ointment class medicine medications such as JINGWANHONG, and analgesic activity is poor, and wound surface oozes out many, and the body fluid amount lost is big, complication such as serious caused hypovolemic shock.
Summary of the invention
The object of the present invention is to provide a kind of easy to usely, the external liniment that is used for the treatment of scalds, burns that therapeutic effect is good, wound healing time is short.
Technical scheme of the present invention: a kind of external liniment that is used for the treatment of scald, burn, the ratio of weight and number of its crude drug is: Radix Et Rhizoma Rhei 7-13 part, Gypsum Fibrosum Preparatum 5-15 part, Pseudobulbus Bletillae (Rhizoma Bletillae) glue 3-10 part and glycerol 3-6 part.
As a kind of improvement of the present invention, the ratio of weight and number of external liniment crude drug is: 6 parts of 9 parts of Radix Et Rhizoma Rhei, 10 parts of Gypsum Fibrosum Preparatum, 6 parts in Pseudobulbus Bletillae (Rhizoma Bletillae) glue and glycerol.
The preparation method of external liniment of the present invention: with the Radix Et Rhizoma Rhei of described parts by weight, Gypsum Fibrosum Preparatum routinely Chinese medicine preparation technology decocting boil three filtrations, three gained filtrates are mixed the back and are concentrated, concentrated solution 75% ethanol extraction, with extracting liquid filtering, heating, heating-up temperature 75 ± 5 degree, ethanol is vapored away fully, and last extracting solution mixes with Pseudobulbus Bletillae (Rhizoma Bletillae) glue, glycerol again.
Modern pharmacological research shows: Radix Et Rhizoma Rhei, Gypsum Fibrosum Preparatum, the Pseudobulbus Bletillae (Rhizoma Bletillae) have that clearing away heat and cooling blood, granulation promoting relieve the pain, the effect of blood circulation promoting and blood stasis dispelling, blood vessel dilating, local microcirculation is improved, promote wound healing, reducing wound surface oozes out, alleviate the edema sexual oppression of local organization, and make pain relief or disappearance, strengthen cellular immunization, the effect of stablizing organismic internal environment; Protection capability by neural reflex mechanism enhancing body stimulates granulation tissue hyperplasia; Dosage form adopts liniment, wound surface can form the protecting film of layer of transparent rapidly, wound surface is isolated from the outside, can protect from infection, reduce wound surface and ooze out, pain relieving is fast and lasting, is convenient to observe the wound healing situation, even 3-degree wound also can play the chance of protection wound surface, minimizing traumatic infection, simultaneously, various bacteria such as staphylococcus, streptococcus had bacteriostasis; Can shorten the blood clotting time, reduce hemorrhagely, help the healing of wound surface.Take a broad view of full side, have heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, granulation promoting relieves the pain, and pulls out dried removing dampness, arresting hemostasia and suppuration, antiviral, strengthen cellular immunization, stablize effects such as organismic internal environment, more the no cicatrix in back, need not more change dressings, damage and the misery having avoided the patient to change dressings causing, it fills a prescription unique, has fully shown the superiority of burn wound's external therapy of Chinese herb.
Clinical trial method: observe in the case I degree scald wound 16 places, II degree scald wound 106 places, III degree scald wound 64 places, scalding area maximum 75%, minimum 0.5%.With the principle of scald wound, be divided into liniment treatment group of the present invention and JINGWANHONG matched group, treatment group liniment by random packet, first medication was smeared once every ten minutes, even be coated with three times, can form the medicament protection film, three medications every day are pressed until recovery from illness in the back; The treatment of matched group external JINGWANHONG is changed dressings once, until wound healing every day.
Observation index: observe patient's spirit, appetite, defecation, wound surface color every day, ooze out, situations such as swelling, incrustation, the formation of skin island, secretions, infection, measure the wound healing area, calculate the wound healing percentage rate.
The result:
1, wound surface changes: wound surface oozes out after the medication of treatment group, swelling, pain degree is light than matched group, and wound surface drying, incrustation, medicine film apply lid after one day, and quality is softer, and the skin island forms two days later, no abnormal secretions and infection etc.
2, wound healing time: it is 1.6 ± 0.4 days that treatment group I degree is scalded, matched group 3.2 ± 0.5 days; It is 8.0 ± 0.3 days that treatment group II degree is scalded, matched group 10.4 ± 0.5 days; It is 19.6 ± 0.5 days that treatment group III degree is scalded, matched group 23.6 ± 0.6 days; Both differences have significance meaning (p＜0.05), and treatment is formed the face healing time and obviously shifted to an earlier date.
JINGWANHONG is widely used in burn clinically; has the effect of relieving the pain of clear and definite granulation promoting; be one of Department of B urn common drug, as can be seen, liniment of the present invention is compared with JINGWANHONG from this is observed; the external liniment is early stage; exudate, redness, pain disappear comparatively fast, form the medicament protection film, and the growth of skin island rapidly; the damage and misery having avoided external stimulation and changed dressings repeatedly and cause are infected the chance of destroying the skin island thereby reduced.Two form the face healing time significant difference, and external liniment group can significantly promote healing speed, improves the wound healing quality, do not have untoward reaction such as infection, the skin healing quality is good, does not stay cicatrix after healing, expense reduces, and cure rate reaches 98%, and the treatment effective percentage reaches 100%.Its typical case history is now taken passages as follows:
Clinical case:
1, the mound woman scalded on May 31st, 2 years old 6 months, with coming diagnosis and treatment, look into the shirtfront, perineum, right lateral thigh, dark II degree is scalded, and accounts for 17% of total body surface area, punctures vesicle coating then with normal saline cleaning wound surface, coating after ten minutes pain obviously alleviate, ooze out obvious minimizing after 12 hours, ooze out after 20 hours and stop, the medicine film covers.Patient's appetite, body temperature, spirit are all normal, and crust begins to come off after 3 days, note the protection crust, in time prune the crust that comes off, and crust all comes off to fully recover and leaves hospital after 8.5 days.
2, the summer woman scalded on June 5th, 15 months, with coming diagnosis and treatment, looked into back II degree and scalded, and normal saline cleaning wound surface, protection scalded skin make its complete nothing damaged, then coating; The rear perimeter edge crust began to come off on 4th, cut off peripheral crust with sterile scissors, continued coating, noted protection wound surface edge, and crust all comes off to fully recover and leaves hospital after 9 days.
3, because of agricultural three-wheel overturns, be pressed in it under car about 10: 30 on the 8th 58 years old in April, 2004 of Lee man, and the water tank boiled water flows out its scald, shirtfront, back, perineum, right lower limb scald, and the gross area reaches 32%, and instep portion injures by a crashing object, with coming diagnosis and treatment.Clean wound surface except that coating behind the crude removal with normal saline, antibiotic intravenous drip prevention infection, coating is the dry incrustation of wound surface after 24 hours, and the medicine film covers, and pounds the injury except that instep portion after 10 days and all heals.
The specific embodiment
Embodiment 1
Take by weighing Radix Et Rhizoma Rhei 9 grams, Gypsum Fibrosum Preparatum 10 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) glue 6 grams and glycerol 5 grams, with Radix Et Rhizoma Rhei, Gypsum Fibrosum Preparatum routinely Chinese medicine preparation technology decocting boil 3 filtrations, concentrate after three times filtrate is mixed, concentrated solution 75% ethanol extraction, with extracting liquid filtering, heating, heating-up temperature 75 ± 5 degree vapor away ethanol fully, and last extracting solution mixes the liniment that promptly gets external Chinese patent medicine of the present invention with Pseudobulbus Bletillae (Rhizoma Bletillae) glue, glycerol again.
Embodiment 2
Take by weighing Radix Et Rhizoma Rhei 7 grams, Gypsum Fibrosum Preparatum 5 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) glue 3 grams and glycerol 3 grams, with Radix Et Rhizoma Rhei, Gypsum Fibrosum Preparatum routinely Chinese medicine preparation technology decocting boil 3 filtrations, concentrate after three times filtrate is mixed, concentrated solution 75% ethanol extraction, with extracting liquid filtering, heating-up temperature 75 ± 5 degree vapor away ethanol fully, and last extracting solution mixes the liniment that promptly gets external Chinese patent medicine of the present invention with Pseudobulbus Bletillae (Rhizoma Bletillae) glue, glycerol again.
Embodiment 3
Take by weighing Radix Et Rhizoma Rhei 13 grams, Gypsum Fibrosum Preparatum 15 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) glue 6 grams and glycerol 6 grams, with Radix Et Rhizoma Rhei, Gypsum Fibrosum Preparatum routinely Chinese medicine preparation technology decocting boil 3 filtrations, concentrate after three times filtrate is mixed, concentrated solution 75% ethanol extraction, with extracting liquid filtering, heating-up temperature 75 ± 5 degree vapor away ethanol fully, and last extracting solution mixes the liniment that promptly gets external Chinese patent medicine of the present invention with Pseudobulbus Bletillae (Rhizoma Bletillae) glue, glycerol again.
Embodiment 4
Take by weighing Radix Et Rhizoma Rhei 10 grams, Gypsum Fibrosum Preparatum 8 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) glue 10 grams and glycerol 5 grams, with Radix Et Rhizoma Rhei, Gypsum Fibrosum Preparatum routinely Chinese medicine preparation technology decocting boil 3 filtrations, concentrate after three times filtrate is mixed, concentrated solution 75% ethanol extraction, with extracting liquid filtering, heating-up temperature 75 ± 5 degree vapor away ethanol fully, and last extracting solution mixes the liniment that promptly gets external Chinese patent medicine of the present invention with Pseudobulbus Bletillae (Rhizoma Bletillae) glue, glycerol again.
Claims (3)
- One kind be used for the treatment of scald, the burn the external liniment, it is characterized in that: the ratio of weight and number of its crude drug is: Radix Et Rhizoma Rhei 7-13 part, Gypsum Fibrosum Preparatum 5-15 part, Pseudobulbus Bletillae (Rhizoma Bletillae) glue 3-10 part and glycerol 3-6 part.
- 2. the external liniment that is used for the treatment of scald, burn according to claim 1, it is characterized in that: the ratio of weight and number of described crude drug is: 6 parts of 9 parts of Radix Et Rhizoma Rhei, 10 parts of Gypsum Fibrosum Preparatum, 6 parts in Pseudobulbus Bletillae (Rhizoma Bletillae) glue and glycerol.
- 3. the preparation method that is used for the treatment of the external liniment of scald, burn according to claim 1 and 2, it is characterized in that: described preparation method be with Radix Et Rhizoma Rhei, Gypsum Fibrosum Preparatum routinely Chinese medicine preparation technology decocting boil three filtrations, concentrate after three times filtrate is mixed, concentrated solution 75% ethanol extraction, with extracting liquid filtering, heating, heating-up temperature 75 ± 5 degree vapor away ethanol fully, and last extracting solution mixes with Pseudobulbus Bletillae (Rhizoma Bletillae) glue, glycerol again.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100617317A CN101041014B (en) | 2007-04-21 | 2007-04-21 | Plaster for treating scald and burn for external application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100617317A CN101041014B (en) | 2007-04-21 | 2007-04-21 | Plaster for treating scald and burn for external application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101041014A CN101041014A (en) | 2007-09-26 |
| CN101041014B true CN101041014B (en) | 2010-07-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007100617317A Expired - Fee Related CN101041014B (en) | 2007-04-21 | 2007-04-21 | Plaster for treating scald and burn for external application |
Country Status (1)
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| CN (1) | CN101041014B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102228555A (en) * | 2011-07-07 | 2011-11-02 | 张宏虎 | Medicinal liquid for treating burns and scalds |
| CN103800940B (en) * | 2012-11-14 | 2015-08-19 | 天津禹王生物医药科技有限公司 | A kind of bleeding-stopping dressing and preparation method |
| CN106266597A (en) * | 2016-08-25 | 2017-01-04 | 时维静 | A kind of Abelmoschus manihot （L.） Medic Bletilla glucomannan spray-filming agent and preparation method thereof |
| CN115970047A (en) * | 2023-01-28 | 2023-04-18 | 贵州省农作物品种资源研究所 | Preparation method of bletilla striata gel freeze-dried powder, and dry powder solid dressing and liquid dressing containing bletilla striata freeze-dried powder |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1190012A (en) * | 1997-02-03 | 1998-08-12 | 辛堂 | Plaster for burn and scald and its preparation |
| CN1237426A (en) * | 1998-05-29 | 1999-12-08 | 朱克尧 | Chinese patent medicine for external application for curing diseases of scald, burn and dermal ulcer |
| CN1679745A (en) * | 2005-02-05 | 2005-10-12 | 崔润生 | External-applied medicine for treating burn, valnus and local tumor inflammation |
-
2007
- 2007-04-21 CN CN2007100617317A patent/CN101041014B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1190012A (en) * | 1997-02-03 | 1998-08-12 | 辛堂 | Plaster for burn and scald and its preparation |
| CN1237426A (en) * | 1998-05-29 | 1999-12-08 | 朱克尧 | Chinese patent medicine for external application for curing diseases of scald, burn and dermal ulcer |
| CN1679745A (en) * | 2005-02-05 | 2005-10-12 | 崔润生 | External-applied medicine for treating burn, valnus and local tumor inflammation |
Non-Patent Citations (4)
| Title |
|---|
| 王军等.白芨胶的临床应用.中国医院药学杂志24 9.2004,24(9),第556-557页. |
| 王军等.白芨胶的临床应用.中国医院药学杂志24 9.2004,24(9),第556-557页. * |
| 马小丽.中医药治疗烧伤的新进展.北京中医杂志21 2.2002,21(2),第120-122页. |
| 马小丽.中医药治疗烧伤的新进展.北京中医杂志21 2.2002,21(2),第120-122页. * |
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| Publication number | Publication date |
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| CN101041014A (en) | 2007-09-26 |
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| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
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| CP02 | Change in the address of a patent holder |
Address after: 78 054700 friendship Street, Hebei, Weixian County Patentee after: Meng Xiangbao Address before: 054700 Hebei province Weixian County street traffic deyitang Department of burns Patentee before: Meng Xiangbao |
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| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20100728 Termination date: 20160421 |