CN1977865A - Method for preparing domestic fungus health care oral liquid - Google Patents
Method for preparing domestic fungus health care oral liquid Download PDFInfo
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- CN1977865A CN1977865A CN 200510101667 CN200510101667A CN1977865A CN 1977865 A CN1977865 A CN 1977865A CN 200510101667 CN200510101667 CN 200510101667 CN 200510101667 A CN200510101667 A CN 200510101667A CN 1977865 A CN1977865 A CN 1977865A
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- grifola frondosa
- agaricus blazei
- blazei murrill
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Abstract
The present invention relates to a preparation method of edible mushroom health-care oral liquor. Said preparation method includes the following steps: (1), using dried pine mushroom and polyporus frondosus as raw material; (2), respectively utilizing microwave auxiliary extraction technique to extract their effective components; (3), making extracts undergo the processes of centrifugal separation, concentration and mixing treatment; (4), adding auxiliary Chinese medicine extract prepared by using Chinese medicinal materials of codonopsis root, poria, astragalus root, cooked rehmannia root and ovate atractylodes root into the above-mentioned mixture; and (5), firstly, using cellulose and pectase to make treatment, then adding chitosan to make treatment. Said oral liquor has the functions of raising immunity of human body, resisting tumor, resisting mutation, reducing blood sugar and preventing diabetes and angiocardiopathy, etc.
Description
Technical field
The present invention relates to a kind of preparation method of edible fungi health care oral liquid.
Background technology
Edible fungi is rich in the multiple nutrients material, particularly contains rich in protein and aminoacid, normally several times of common vegetable and fruit to tens times.Much studies show that in recent years, many edible fungi contain one or more functional components, aspect prevention, treatment disease and the raising body immunity effect unique is being arranged, therefore extract from edible fungi in recent years and exploitation health food and medicine have caused the attention of many research and development organizations, some product has formed the industry of certain scale.Agaricus blazei Murrill and Grifola frondosa all belong to rare edible fungi, are the food medicine dual-purpose kinds with large development potentiality of discovered in recent years.
Agaricus blazei Murrill originates in ground such as Brazil, Peru, so claim Brazilian mushroom again.Recent study finds, its sporophore contains rich nutrient substances and biological active substances such as polysaccharide, nucleic acid, sterols etc.According to studies show that of Japan, it has miraculous effects to antitumor, and the active polysaccharide that contains in its sporophore reaches 99% to the suppression ratio of tumor; The Agaricus blazei Murrill extract is remarkable in aspect effects such as blood fat reducing, anticoagulations in addition, and diseases such as apoplexy, myocardial infarction, renal insufficiency, hemorrhoid, neuralgia are had certain curative effect.
Grifola frondosa mainly is distributed in the subtropical zone to the area, temperate zone, according to Ministry of Agriculture quality inspection center and Chinese Academy Of Preventive Medicine Research Institute Of Nutrition And Food Hygiene's check, contain protein 32% in the Grifola frondosa dry product, wherein contain 18 seed amino acids, total amount nearly 20%, carbohydrate 50% and multivitamin and trace element, to improving food composition, balanced nutrients composition and raising body have important function to proteinic utilization rate.Studies show that in recent years, grifolan has tangible AIDS virus resisting, antitumor, improves function of immune system, energy blood sugar regulation and cholesterol levels, to generation and the transfer that prevents cancerous cell, treatment acquired immune deficiency syndrome (AIDS), hypertension, obesity, diabetes all have better curative effect, and without any side effects.Its anti-tumor activity particularly, the Japan medical science expert carries out the anti-tumor experiment result with grifolan and shows that the tumour inhibiting rate of grifolan can reach 86.5%, and is higher by 32% than internationally recognized PTS lentinan suppression ratio.Therefore, Grifola frondosa has important medicines and health protection value.
Because Agaricus blazei Murrill and Grifola frondosa all contain higher important biological active substances such as polysaccharide etc. to the human body beneficial, certain similarity is arranged on function, but it is different again on nutritional labeling and function, they are combined be developed into product, can learn from other's strong points to offset one's weaknesses, promote the harmony of nutrient substance, the raising human body has the absorption and the utilization of various favourable compositions, helps strengthening the effect of biological active substances.
In China, Agaricus blazei Murrill and Grifola frondosa in Fujian, Zhejiang, Jiangsu, Shandong etc. economize existing a large amount of cultivation, except that the supply domestic market, considerable part exports to ground such as Japan, the U.S., Korea S, Singapore, China Taiwan, Hong Kong, and it is quite abundant therefore processing raw material.
Summary of the invention
The object of the present invention is to provide a kind of preparation method of edible fungi health care oral liquid.
For achieving the above object, the present invention includes following steps:
(1) be raw material with drying Agaricus blazei Murrill and Grifola frondosa;
(2) Agaricus blazei Murrill and Grifola frondosa pulverize separately are crossed 200 mesh sieves;
(3) Agaricus blazei Murrill and Grifola frondosa are used the microwave auxiliary extraction technology respectively, and effective ingredient is wherein extracted;
(4) to step (3) gained extracting solution filtered while hot, with centrifuge centrifuging and taking supernatant under 3000-5000r/min;
(5) supernatant to step (4) gained carries out vacuum concentration respectively, is concentrated into 1/2 of original volume;
(6) step (5) gained Agaricus blazei Murrill and Grifola frondosa concentrated solution are pressed 1: 1 mixed;
(7) step (6) gained Agaricus blazei Murrill and Grifola frondosa mixed liquor are allocated;
(8) the deployed mixed liquor of step (7) gained is carried out clarifying treatment.
(9) fill, seal and carry out sterilization processing.
To adopt water be solvent for Agaricus blazei Murrill and Grifola frondosa extracts active ingredients in the step of the present invention (3), and process conditions are as follows: Agaricus blazei Murrill extraction time is 15-20min, and temperature remains on 80-90 ℃ under the microwave environment, and ratio of water to material is 10-15: 1; Grifola frondosa extraction time is 10-15min, and temperature remains on 80-90 ℃ under the microwave environment, and ratio of water to material is 10-15: 1.
Step of the present invention (7) can add the auxiliary Chinese medicine extraction liquid by Radix Codonopsis 21-25%, Poria 16-25%, Radix Astragali 16-20%, Radix Rehmanniae Preparata 16-25%, the Rhizoma Atractylodis Macrocephalae 16-20% preparation when Agaricus blazei Murrill and Grifola frondosa mixed liquor are allocated.
The preparation process of the auxiliary Chinese medicine extraction liquid of the present invention is: get Radix Codonopsis 21-25%, Poria 16-25%, Radix Astragali 16-20%, Radix Rehmanniae Preparata 16-25%, Rhizoma Atractylodis Macrocephalae 16-20%, add 6-10 times of decocting in water, boil to residue, the water yield is 2.5 times of Chinese medicine gross weight, filtered while hot, 3000-5000r/min is centrifugal, obtains auxiliary Chinese medicine extraction liquid.
Allocation process is among the present invention: 1) get the auxiliary Chinese medicine extraction liquid of 60-80% step 6 gained Agaricus blazei Murrill and Grifola frondosa mixed liquor and 20-40% and be hybridly prepared into mother solution; 2) press the mother solution volume and add 12-18% sucrose; 3) dissolving mixing.
The deployed mixed liquor defecation method of step of the present invention (8) is as follows: transfer pH to 4.5-5.0, press mixeding liquid volume than adding 0.5-1% cellulase and 0.2-0.5% pectase, 55-60 ℃ of constant temperature 1-3h, the centrifugal precipitation of going under the 3000-5000r/min condition then.Supernatant adds the chitosan of 0.05-0.1% by volume, leaves standstill 20-30min after fully mixing, the centrifugal precipitation of going under the 3000-5000r/min condition.
The oral liquid of the present invention's preparation has the function of following several respects:
1, the human immune system there is regulating action.Energy activated T cell, B cell, macrophage, natural killer cell promote macrophage secrete cytokines (as: IL6, IL1 and TNF-α) etc., thereby improve immune function of human body;
2, antitumor, mutation-resisting functional.Can suppress tumor generates and to normal impact cell seldom, can also block normal cell and become mutant cell;
3, blood sugar lowering and prevent diabetes function.Can reduce hepatic glycogen, promote the utilization of peripheral organization such as liver, muscle and target organ sugar; Regulate associated hormone as promoting insulin secretion, suppress epinephrine, glucagon etc. and rise C-21 cortico-steroid, the activity of protection islet cells and adjusting carbohydrate metabolism relevant enzyme;
4, anticoagulation, adjusting human body blood fat and cholesterol levels, angiocardiopathy preventing takes place.
5, diseases such as apoplexy, myocardial infarction, renal insufficiency, hemorrhoid, neuralgia there is certain curative effect
The specific embodiment
Embodiment one
1, the dried mushroom of Agaricus blazei Murrill and Grifola frondosa is pulverized, and crosses 200 mesh sieves, takes by weighing Agaricus blazei Murrill dry powder 10kg and Grifola frondosa dry powder 8kg respectively;
2, respectively add water 100kg in Agaricus blazei Murrill and Grifola frondosa dry powder, use microwave auxiliary extraction technology effective component extracting respectively, Agaricus blazei Murrill extraction time is 15min, and Grifola frondosa extraction time is 15min, and temperature all is controlled at 85-95 ℃ under the microwave environment;
3, extracting solution is filtered with the plate and frame filter respectively while hot, with centrifuge centrifuging and taking supernatant under 3000r/min;
4, supernatant is carried out vacuum concentration respectively, be concentrated into weight and respectively be 50kg;
5, Agaricus blazei Murrill and Grifola frondosa extracting solution are pressed 1: 1 mixed, add auxiliary Chinese medicine extraction liquid allotment then in the mixed liquor.The preparation of auxiliary Chinese medicine extraction liquid is by following prescription and step: get Radix Codonopsis 5kg, Poria 4.2kg, Radix Astragali 3.6kg, Radix Rehmanniae Preparata 3.2kg, Rhizoma Atractylodis Macrocephalae 4kg adds the 160kg decocting in water, boil to residue 50kg water, filtered while hot, 5000r/min is centrifugal to remove slag, and promptly obtains auxiliary Chinese medicine extraction liquid;
6, allocate preparation as follows: get Agaricus blazei Murrill and Grifola frondosa mixed liquor 60kg, add auxiliary Chinese medicine extraction liquid 40kg, add sucrose 15kg, fully dissolve mixing;
7, deployed mixed liquor is clarified.Transfer pH to 4.5, add 1kg cellulase and 0.35kg pectase, 55 ℃ of constant temperature 2h, the centrifugal precipitation of going of 3000r/min then.Supernatant adds the chitosan of 0.1kg, and fully dissolving is left standstill 30min after mixing, the centrifugal precipitation of going of 3000r/min;
8, step 7 gained clear liquor is carried out fill and seal, carry out sterilization processing (10～20～10min/121 ℃) then.
Embodiment two
1, the dried mushroom of Agaricus blazei Murrill and Grifola frondosa is pulverized, and crosses 200 mesh sieves, takes by weighing Agaricus blazei Murrill dry powder 8kg and Grifola frondosa dry powder 10kg respectively;
2, respectively add water 100kg in Agaricus blazei Murrill and Grifola frondosa dry powder, use microwave auxiliary extraction technology effective component extracting respectively, Agaricus blazei Murrill extraction time is 17.5min, and Grifola frondosa extraction time is 10min, and temperature all is controlled at 85-95 ℃ under the microwave environment;
3, extracting solution is filtered with the plate and frame filter respectively while hot, with centrifuge centrifuging and taking supernatant under 4000r/min;
4, supernatant is carried out vacuum concentration respectively, be concentrated into weight and respectively be 50kg;
5, Agaricus blazei Murrill and Grifola frondosa extracting solution are pressed 1: 1 mixed, add auxiliary Chinese medicine extraction liquid allotment then in the mixed liquor.The preparation of auxiliary Chinese medicine extraction liquid is by following prescription and step: get Radix Codonopsis 4.2kg, Poria 5kg, Radix Astragali 3.2kg, Radix Rehmanniae Preparata 4kg, Rhizoma Atractylodis Macrocephalae 3.6kg adds the 120kg decocting in water, boil to residue 50kg water, filtered while hot, 3000r/min is centrifugal to remove slag, and promptly obtains auxiliary Chinese medicine extraction liquid;
6, allocate preparation as follows: get Agaricus blazei Murrill and Grifola frondosa mixed liquor 70kg, add auxiliary Chinese medicine extraction liquid 30kg, add sucrose 12kg, fully dissolve mixing;
7, deployed mixed liquor is clarified.Transfer pH to 4.75, add 0.5kg cellulase and 0.5kg pectase, 60 ℃ of constant temperature 1h, the centrifugal precipitation of going of 5000r/min then.Supernatant adds the chitosan of 0.05kg, and fully dissolving is left standstill 20min after mixing, the centrifugal precipitation of going of 5000r/min;
8, step 7 gained clear liquor is carried out fill and seal, carry out sterilization processing (10～20～10min/121 ℃) then.
Embodiment three
1, the dried mushroom of Agaricus blazei Murrill and Grifola frondosa is pulverized, and crosses 200 mesh sieves, takes by weighing Agaricus blazei Murrill dry powder 6.7kg and Grifola frondosa dry powder 6.7kg respectively;
2, respectively add water 100kg in Agaricus blazei Murrill and Grifola frondosa dry powder, use microwave auxiliary extraction technology effective component extracting respectively, Agaricus blazei Murrill extraction time is 20min, and Grifola frondosa extraction time is 12.5min, and temperature all is controlled at 85-95 ℃ under the microwave environment;
3, extracting solution is filtered with the plate and frame filter respectively while hot, with centrifuge centrifuging and taking supernatant under 5000r/min;
4, supernatant is carried out vacuum concentration respectively, be concentrated into weight and respectively be 50kg;
5, Agaricus blazei Murrill and Grifola frondosa extracting solution are pressed 1: 1 mixed, add auxiliary Chinese medicine extraction liquid allotment then in the mixed liquor.The preparation of auxiliary Chinese medicine extraction liquid is by following prescription and step: get Radix Codonopsis 4.6kg, Poria 4kg, Radix Astragali 4kg, Radix Rehmanniae Preparata 4.2kg, Rhizoma Atractylodis Macrocephalae 3.2kg adds the 200kg decocting in water, boil to residue 50kg water, filtered while hot, 4000r/min is centrifugal to remove slag, and promptly obtains auxiliary Chinese medicine extraction liquid;
6, allocate preparation as follows: get Agaricus blazei Murrill and Grifola frondosa mixed liquor 80kg, add auxiliary Chinese medicine extraction liquid 20kg, add sucrose 18kg, fully dissolve mixing;
7, deployed mixed liquor is clarified.Transfer pH to 5.0, add 0.75kg cellulase and 0.2kg pectase, 57.5 ℃ of constant temperature 3h, the centrifugal precipitation of going of 4000r/min then.Supernatant adds the chitosan of 0.075kg, and fully dissolving is left standstill 25min after mixing, the centrifugal precipitation of going of 4000r/min;
8, step 7 gained clear liquor is carried out fill and seal, carry out sterilization processing (10～20～10min/121 ℃) then.
Claims (7)
1, a kind of preparation method of edible fungi health care oral liquid is characterized in that may further comprise the steps:
(1) be raw material with drying Agaricus blazei Murrill and Grifola frondosa;
(2) Agaricus blazei Murrill and Grifola frondosa pulverize separately are crossed 200 mesh sieves;
(3) Agaricus blazei Murrill and Grifola frondosa are used the microwave auxiliary extraction technology respectively, and effective ingredient is wherein extracted;
(4) to step (3) gained extracting solution filtered while hot, with centrifuge centrifuging and taking supernatant under 3000-5000r/min;
(5) supernatant to step (4) gained carries out vacuum concentration respectively, is concentrated into 1/2 of original volume;
(6) step (5) gained Agaricus blazei Murrill and Grifola frondosa concentrated solution are pressed 1: 1 mixed;
(7) step (6) gained Agaricus blazei Murrill and Grifola frondosa mixed liquor are allocated;
(8) the deployed mixed liquor of step (7) gained is carried out clarifying treatment.
(9) fill, seal and carry out sterilization processing.
2, the preparation method of a kind of edible fungi health care oral liquid according to claim 1 is characterized in that in the step (1) with drying Agaricus blazei Murrill and Grifola frondosa being raw material.
3, the preparation method of a kind of edible fungi health care oral liquid according to claim 1, it is characterized in that step (3) uses the microwave auxiliary extraction technology: Agaricus blazei Murrill extraction time is 15-20min, temperature remains on 80-90 ℃ under the microwave environment, and ratio of water to material is 10-15: 1; Grifola frondosa extraction time is 10-15min, and temperature remains on 80-90 ℃ under the microwave environment, and ratio of water to material is 10-15: 1.
4, the preparation method of a kind of edible fungi health care oral liquid according to claim 1, its feature add when being step (7) allotment by the auxiliary Chinese medicine extraction liquid of Radix Codonopsis 21-25%, Poria 16-25%, Radix Astragali 16-20%, Radix Rehmanniae Preparata 16-25%, Rhizoma Atractylodis Macrocephalae 16-20% preparation allocates.
5, the preparation method of a kind of edible fungi health care oral liquid according to claim 4, the preparation process that it is characterized in that auxiliary Chinese medicine extraction liquid is: get Radix Codonopsis 21-25%, Poria 16-25%, Radix Astragali 16-20%, Radix Rehmanniae Preparata 16-25%, Rhizoma Atractylodis Macrocephalae 16-20%, add 6-10 times of decocting in water, boil to residue, the water yield is 2.5 times of Chinese medicine gross weight, filtered while hot, 3000-5000r/min is centrifugal, obtains auxiliary Chinese medicine extraction liquid.
6, the preparation method of a kind of edible fungi health care oral liquid according to claim 4 is characterized in that allocation process is: 1) get the auxiliary Chinese medicine extraction liquid of 60-80% step (6) gained Agaricus blazei Murrill and Grifola frondosa mixed liquor and 20-40% and be hybridly prepared into mother solution; 2) press the mother solution volume and add 12-18% sucrose; 3) dissolving mixing.
7, the preparation method of a kind of edible fungi health care oral liquid according to claim 1, it is characterized in that in the step (8) deployed mixed liquor being carried out clarifying treatment: transfer pH to 4.5-5.0, press mixeding liquid volume than adding 0.5-1% cellulase and 0.2-0.5% pectase, 55-60 ℃ of constant temperature 1-3h, centrifugal going precipitated under the 3000-5000r/min condition then, supernatant adds the chitosan of 0.05-0.1% by volume, leave standstill 20-30min after fully mixing, the centrifugal precipitation of going under the 3000-5000r/min condition.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2005101016671A CN1977865B (en) | 2005-11-30 | 2005-11-30 | Method for preparing domestic fungus health care oral liquid |
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| CN2005101016671A CN1977865B (en) | 2005-11-30 | 2005-11-30 | Method for preparing domestic fungus health care oral liquid |
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| CN1977865A true CN1977865A (en) | 2007-06-13 |
| CN1977865B CN1977865B (en) | 2010-10-06 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102068468A (en) * | 2009-12-31 | 2011-05-25 | 成都科尔医药技术有限公司 | Method for treating traditional Chinese medicinal extraction solution before preparation |
| CN104068302A (en) * | 2013-03-29 | 2014-10-01 | 烟台大学 | Enteromorpha polysaccharide oral liquid and preparation method thereof |
| CN105687277A (en) * | 2016-03-17 | 2016-06-22 | 天津元恒德科技有限公司 | Composite for improving immunity and application |
| CN113679786A (en) * | 2021-07-09 | 2021-11-23 | 杭州雪域生物技术有限公司 | Composition of red yeast rice, agaricus blazei murill and grifola frondosa and preparation method and application thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1078051C (en) * | 1998-07-21 | 2002-01-23 | 李健 | Method for preparing health-care food contg. chinese caterpillar fungus |
-
2005
- 2005-11-30 CN CN2005101016671A patent/CN1977865B/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102068468A (en) * | 2009-12-31 | 2011-05-25 | 成都科尔医药技术有限公司 | Method for treating traditional Chinese medicinal extraction solution before preparation |
| CN104068302A (en) * | 2013-03-29 | 2014-10-01 | 烟台大学 | Enteromorpha polysaccharide oral liquid and preparation method thereof |
| CN105687277A (en) * | 2016-03-17 | 2016-06-22 | 天津元恒德科技有限公司 | Composite for improving immunity and application |
| CN113679786A (en) * | 2021-07-09 | 2021-11-23 | 杭州雪域生物技术有限公司 | Composition of red yeast rice, agaricus blazei murill and grifola frondosa and preparation method and application thereof |
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| Publication number | Publication date |
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| CN1977865B (en) | 2010-10-06 |
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