CN1957965A - Chinese traditional medicine preparation for treating impotence, and preparation method - Google Patents

Abstract

A Chinese medicine for treating impotence is prepared from cordyceps sporophore, extract of pine needle, and extract of epimedium. Its preparing process is also disclosed.

Description

A kind of Chinese medicine preparation for the treatment of sexual impotence and preparation method thereof

Technical field

The invention belongs to Chinese medicine preparation and preparation method thereof, particularly a kind of Chinese medicine preparation for the treatment of sexual impotence and preparation method thereof.

Background technology

Sexual impotence is meant that penis can not reach or keep the erection of the sexual intercourse that is enough to be satisfied with, and is the commonly encountered diseases of middle-aging male, and the male suffers from various degree that the ratio of erection disturbance surpasses 50%.Because the influence of traditional habit, the Chinese medicine preparation of existing treatment sexual impotence mostly is to subsidize human body by traditional Chinese medical science classification, can treat the yang-tonifying drug of YANG asthenia disease.In fact the erection process of penis is at nerve--the hemodynamic a series of physiological changies of arteria penis and cavernous body of penis under the endocrine adjusting.Under the regulation and control of NO-cGMP signal path, arteria penis and cavernous body of penis smooth muscle loosening, cavernous body of penis inner blood perfusion flow increase and make erection during sexual stimulus.The erection disturbance person, the regulation and control generation pathophysiology of cavernous body of penis NO-cGMP signal path changes, and causes the incomplete or venous occlusion functional defect of cavernous body of penis blood engorgement, and causes penile erectile function obstacle--sexual impotence.Only can not solve central nervous excitation, so existing Chinese patent medicine is in the poor effect of treatment impotence, enhancing sexual function with yang-tonifying drug.

Summary of the invention

The purpose of this invention is to provide a kind of Chinese medicine preparation for the treatment of sexual impotence and preparation method thereof, select Cordyceps sporophore, extract from pine needles, Herba Epimedii extract compatibility for use, from dredging vascellum, improve blood circulation, the blood circulation of the impaired little blood vessel of cavernous body of penis is set out, when sexual stimulus, cavernous body of penis inner blood perfusion flow is full, thereby sexual impotence is improved and rehabilitation.

Parts by weight of raw materials of the present invention is:

Cordyceps sporophore 10-80 part

Extract from pine needles 5-30 part

Herba Epimedii extract 5-30 part

Preparation method of the present invention: with Cordyceps sporophore in 50 ℃ of hot blasts dry 2 hours, be crushed to 200 orders with Chinese medicine grinder,, be filled to the 0# capsule with extract from pine needles, the abundant mix homogeneously of Herba Epimedii extract, be packaged in the medicine special-purpose bottle by quantity, through irradiation product.

The present invention is more effective than the Chinese patent medicine of existing treatment sexual impotence, have curative effect rapidly, the characteristics that have no side effect, oral, take taking convenience with eliminating cold for resuscitation water or with the soup of eating.

The specific embodiment

Cordyceps sporophore among the present invention is that the Cordyceps militaris (L.) Link. of artificial implantation is the sporophore of Cordyceps militaris (L.) Link. (Cordyceps militaris), the Cordyceps sporophore contains Cordyceps polysaccharide, Cordyceps rope, cordycepic acid, adenosine and superoxide dismutase (SOD), for cholesterol reducing, blood fat reducing, the heart illness disease that treatment causes because of hypertension, improve cardiac function, increase the amount of blood supply of cardiac muscle and brain.To helping hepatic clearance vivotoxin, the liver protecting cell.To promoting the renal tubular cell reparation, nourishing renal function, replenishing vital essence and invigorating vital QI, enriching yin and nourishing kidney.To strengthen lung functions, invigorating the lung and benefiting vital QI, to improve sleep, the daily pressure of releiving, to promote hemopoietic function, microcirculation improvement, raising immunity, quicken the cell renewal, antioxidation, slow down aging, rapidly allaying tiredness, recover physical ability etc., have extensive and obvious effect.

Extract from pine needles among the present invention is the needle 20kg that gets air dried Pinus tabuliformis or Pinus massoniana Lamb, puts into stainless-steel pan, adds tap water 200kg again in pot, be heated to 100 ℃, be incubated 2 hours, filter, get filtrate, in the Folium Pini filtering residue, add tap water 200kg, be heated to 100 ℃, be incubated 2 hours, filter, get filtrate, twice filtrate is merged, be evaporated to 20kg, use vacuum drying, crushed after being dried gets 20: 1 extract from pine needles 1kg.The eighties in last century, the Chinese scholar finds that extract from pine needles contains multiple water-soluble flavone chemical compound in seeking the long-lived useful plant of human health, can be used for prevention and treatment arteriosclerosis, hypertension, high blood viscosity, diabetes, coronary heart disease, angina pectoris, arrhythmia, cerebral infarction, cerebral arteriosclerosis, senile dementia, knotty problem medically such as sudden deafness.It is compound antioxidation (defying age) material of the best of finding of document record up to now in the world and laboratory.And be that modern times " affluenza " its common ground of representative all is blood with hyperlipidemia, hypercholesterolemia, fatty liver, hypertension, arteriosclerosis, diabetes.Blood is not delivered to each corner of human body to oxygen and nutrition with not stopping not have a rest, and required energy and material when the human body metabolic activity is provided do not have it, and life will stop.After people in middle age, blood thickens, hands over thick, deepening, because many excess fats of having deposited,, cholesterol and other noxious substance, in the course of time, the dense thick blood vessels thicken that causes of blood is hardened, the blood vessel space diminishes, and blood circulation is not smooth, and the thrombosis microgranule condenses etc., cause into hypertension, blood vessel scleratheroma, myocardial infarction, coronary heart disease, even serial mortality disease such as apoplexy.The pathological changes of blood blood vessel is involved the little blood vessel of cavernous body of penis inevitably, causes blood vessel perfusion flow deficiency in the cavernous body of penis, venous occlusion functional defect and cause sexual impotence.Extract from pine needles energy dredging vascellum improves blood circulation, makes the blood circulation of impaired part, improves the nutrient environment of impaired part, and the cell of impaired part is brought back to life, and sexual impotence is improved and rehabilitation rapidly.

Herba Epimedii extract among the present invention is an icariine, and its extraction step is as follows:

(1) get Herba Epimedii aerial parts 10kg and put into rustless steel container, add tap water 100kg in container, soak at room temperature 1 hour is heated to 100 ℃ then, be incubated 2 hours, filter, get filtrate, in filtering residue, add tap water 50kg again, be heated to 100 ℃, be incubated 1 hour, filter, get filtrate;

(2) merge twice filtrate, be evaporated to 20kg;

(3) with concentrated solution with 4000 rev/mins centrifugal 3 minutes, get supernatant;

(4) supernatant passes through

10cm, the macroporous resin column of long 100cm makes the icariine in the liquid be absorbed by resin, discard effluent,, discard effluent with 10kg deionized water rinsing resin column, ethanol with 65% cleans resin column, makes the complete eluting of icariine of absorption, collects eluent;

(5) eluent is put into the still of taking back flow condenser, added 50g medical active carbon, reflux 30 minutes waits to reduce to 40 ℃, filters with pressure filter, collects cleaner liquid;

(6) the cleaner liquid concentrating under reduced pressure is reclaimed ethanol, remaining thing vacuum drying must contain 40% icariine crude product;

(7) with 40% ethanol water with the icariine dissolving crude product, carry out recrystallization three times, must contain the pure product of 98% icariine.

Herba Epimedii is that motherland's medical science is used for the handicapped active drug of therapeutic, utilize modern technologies to extract the Main Ingredients and Appearance icariine of Herba Epimedii, icariine is not only by activating the increased activity erection function of NO-cGMP signal path, and cause the variation of erection related gene and recover the pathophysiological change of erection disturbance, make this motherland's medical medicine of Herba Epimedii in the disease of treatment sexual impotence, premature ejaculation, seminal emission, make bigger chastity and offer.

Cordyceps sporophore, extract from pine needles, Herba Epimedii extract compatibility, combination is prepared a kind of rapid treatment impotence, enhancing sexual function and the Chinese medicine preparation that has no side effect.

Embodiment 1

Each drug weight during preparation 1000 grams:

Cordyceps sporophore 625 grams

20: 1 extract from pine needles 250 grams

40% Herba Epimedii extract, 125 grams

Preparation method: with Cordyceps sporophore in 50 ℃ of hot blasts dry 2 hours, be crushed to 200 orders, take by weighing Cordyceps sporophore 625 grams by prescription with Chinese medicine grinder; Extract from pine needles 250 grams; Herba Epimedii extract 125 gram, fully mix homogeneously is filled to the 0# capsule, 400 milligrams of every 0# capsule net contents, quantity medicine special-purpose bottle packing in accordance with regulations, through irradiation product.

Usage and consumption: oral, with eliminating cold for resuscitation water or with meal soup take.One time 2,2 times on the one.Take all left and right sides sexual dysfunction and obviously improve sexual function improving.

Embodiment 2

Each drug weight during preparation 1000 grams:

Cordyceps sporophore 700 grams

20: 1 extract from pine needles 250 grams

98% Herba Epimedii extract, 50 grams

Preparation method: with Cordyceps sporophore in 50 ℃ of hot blasts dry 2 hours, be crushed to 200 orders, take by weighing Cordyceps sporophore 700 grams by prescription with Chinese medicine grinder; Extract from pine needles 250 grams; Herba Epimedii extract 50 gram, fully mix homogeneously is filled to the 0# capsule, 400 milligrams of every 0# capsule net contents, quantity is packed with the medicine special-purpose bottle in accordance with regulations, through irradiation product.

Usage and consumption: oral, with eliminating cold for resuscitation water or with meal soup take.One time 2,2 times on the one.Take all left and right sides sexual dysfunction and obviously improve sexual function improving.

Claims (5)

1, a kind of Chinese medicine preparation for the treatment of sexual impotence is characterized in that by following parts by weight proportioning:

Cordyceps sporophore 10-80 part

Extract from pine needles 5-30 part

40% Herba Epimedii extract 5-30 part.

2, a kind of preparation method for the treatment of the Chinese medicine preparation of sexual impotence is characterized in that Cordyceps sporophore in 50 ℃ of hot blasts dry 2 hours is crushed to 200 orders with Chinese medicine grinder, takes by weighing Cordyceps sporophore 625 grams by prescription; Extract from pine needles 250 grams; Herba Epimedii extract 125 gram, fully mix homogeneously is filled to the 0# capsule, 400 milligrams of every 0# capsule net contents, quantity is packed with the medicine special-purpose bottle in accordance with regulations, through irradiation product.

3,, it is characterized in that the Cordyceps sporophore is that the Cordyceps militaris (L.) Link. of artificial implantation is the sporophore of Cordyceps militaris (L.) Link. according to the described a kind of Chinese medicine preparation for the treatment of sexual impotence of claim 1.

4,, it is characterized in that extract from pine needles is the needle 20kg that gets air dried Pinus tabuliformis or Pinus massoniana Lamb, puts into stainless-steel pan according to the described a kind of Chinese medicine preparation for the treatment of sexual impotence of claim 1, in pot, add tap water 200kg again, be heated to 100 ℃, be incubated 2 hours, filter, get filtrate, in the Folium Pini filtering residue, add tap water 200kg, be heated to 100 ℃, be incubated 2 hours, filter, get filtrate, twice filtrate is merged, be evaporated to 20kg, use vacuum drying, crushed after being dried gets 20: 1 extract from pine needles 1kg.

5, according to the described a kind of Chinese medicine preparation for the treatment of sexual impotence of claim 1, it is characterized in that Herba Epimedii extract is an icariine, its extraction step is as follows:

(1) get Herba Epimedii aerial parts 10kg and put into rustless steel container, add tap water 100kg in container, soak at room temperature 1 hour is heated to 100 ℃ then, be incubated 2 hours, filter, get filtrate, in filtering residue, add tap water 50kg again, be heated to 100 ℃, be incubated 1 hour, filter, get filtrate;

(2) merge twice filtrate, be evaporated to 20kg;

(3) with concentrated solution with 4000 rev/mins centrifugal 3 minutes, get supernatant;

(4) supernatant passes through 10cm, the macroporous resin column of long 100cm makes the icariine in the liquid be absorbed by resin, discard effluent,, discard effluent with 10kg deionized water rinsing resin column, ethanol with 65% cleans resin column, makes the complete eluting of icariine of absorption, collects eluent;

(5) eluent is put into the still of taking back flow condenser, added 50g medical active carbon, reflux 30 minutes waits to reduce to 40 ℃, filters with pressure filter, collects cleaner liquid;

(6) the cleaner liquid concentrating under reduced pressure is reclaimed ethanol, remaining thing vacuum drying must contain 40% icariine crude product;

(7) with 40% ethanol water with the icariine dissolving crude product, carry out recrystallization three times, must contain the pure product of 98% icariine.