CN110151940A - A kind of Chinese medicine composition and preparation method thereof of invigorating the spleen warm kidney - Google Patents
A kind of Chinese medicine composition and preparation method thereof of invigorating the spleen warm kidney Download PDFInfo
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- CN110151940A CN110151940A CN201910380621.XA CN201910380621A CN110151940A CN 110151940 A CN110151940 A CN 110151940A CN 201910380621 A CN201910380621 A CN 201910380621A CN 110151940 A CN110151940 A CN 110151940A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/648—Myriapods, e.g. centipedes or millipedes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/066—Clavicipitaceae
- A61K36/068—Cordyceps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/884—Alismataceae (Water-plantain family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9064—Amomum, e.g. round cardamom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
Abstract
It is composed of the following components by weight percentage the invention discloses a kind of Chinese medicine composition of invigorating the spleen warm kidney: ginseng 6~10%, fermentation cordyceps 4~7%, Poria cocos 15~20%, rheum officinale 6~10%, rhizoma alismatis 11~15%, endothelium corneum gigeriae galli 10~13%, pheretima 4~7%, leech 13~16%, centipede 4~6%, fructus amomi 5~8%, Medicated Leaven 17~20%, the weight percent summation of the above each component are 100%.The invention also discloses the preparation methods of above-mentioned Chinese medicine composition, it first crushes each raw material stoving, Poria cocos, rheum officinale, rhizoma alismatis, endothelium corneum gigeriae galli, pheretima, leech, centipede, fructus amomi and Medicated Leaven are successively carried out to parch, crushing, ethyl alcohol extraction, concentration, drying, it is finally mixed with other raw materials, is packed into capsule to obtain the final product.The all medicine phases 5 of the present invention, play replenish qi to invigorate the spleen altogether, warm kidney consolidates, and has the benefits of activating blood and promoting diuresis.
Description
Technical field
The invention belongs to pharmaceutical technology fields, are related to a kind of Chinese medicine composition of invigorating the spleen warm kidney, further relate to treat the one kind
The preparation method of the Chinese medicine composition of invigorating the spleen warm kidney.
Background technique
Growth and development, aging, the death of people, there is close relationship with kidney, therefore has " the kidney being the origin of congenital constitution ", " life
Root " say, Chinese medicine thinks: kidney be store essential substances institute, be constitute human body, maintain human life activity base substance.Back pain
Bitterly, leg cramps, tooth falling out, hypogona dism are the performance of physiological function decline.Kidney deficiency, especially kidney-yang deficiency person, it is above-mentioned
Performance becomes apparent.Modern studies have found that the Elderly people of change and physiological kidney deficiency in deficiency of kidney-YANG syndrome, thyroid gland, gonad axis
People is compared, closely similar.It is low that kidney-yang deficiency person often shows as functional activity, " prematurely senile " sign occurs.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine compositions of invigorating the spleen warm kidney, solve speen-kidney dificiency, water-wet stasis blocking institute
The problem of causing edema of limbs and trunks.
It is a further object of the present invention to provide a kind of preparation methods of the Chinese medicine composition of invigorating the spleen warm kidney.
The first technical solution of the present invention is a kind of Chinese medicine composition of invigorating the spleen warm kidney, by weight percentage
It is composed of the following components: ginseng 6~8%, fermentation cordyceps 4~7%, Poria cocos 12~15%, rheum officinale 6~10%, rhizoma alismatis 10
~12%, endothelium corneum gigeriae galli 10~13%, pheretima 4~7%, leech 10~13%, centipede 4~6%, fructus amomi 5~7%, Medicated Leaven 11
~25%, the weight percent summation of the above each component is 100%.
Second of technical solution of the present invention is a kind of preparation method of the Chinese medicine composition of invigorating the spleen warm kidney, packet
Include following steps specific implementation:
Step 1 weighs ginseng 6~8% according to weight percent respectively, fermentation cordyceps 4~7%, and Poria cocos 12~
15%, rheum officinale 6~10%, rhizoma alismatis 10~12%, endothelium corneum gigeriae galli 10~13%, pheretima 4~7%, leech 10~13%, centipede 4~
6%, fructus amomi 5~7%, Medicated Leaven 11~25%, the weight percent summation of the above each component is 100%；
The weighed fermentation cordyceps of step 1 are sieved by step 2, and ginseng is dried and ground, is sieved after grinding；
Step 3, by the weighed Poria cocos of step 1, rheum officinale, rhizoma alismatis, endothelium corneum gigeriae galli, pheretima, leech, centipede, fructus amomi and Medicated Leaven
Parch in batches, parch crush to parching completely, smash it through 50 meshes, obtain coarse powder；
Coarse powder obtained in step 3 is uniformly mixed by step 4, and 40~80% ethyl alcohol of mixed powder is extracted 2 times and mistake
Filter, filtrate are concentrated to give liquid extract, dry obtained dried cream powder；
Ginseng fine powder and fermentation cordyceps that dried cream powder that step 4 obtains and step 2 obtain are uniformly mixed by step 5,
Encapsulating capsule to obtain the final product.
The present invention uses the characteristics of second of technical solution to also reside in,
Drying uses heat pump ginseng dryer in step 2, and drying temperature is 70~85 DEG C, and drying time is 10~15 small
When, drying power is 3kW~5kW, and grinding uses XDW-F100 micronizer.
Fermentation cordyceps sieve with 100 mesh sieve in step 2, and ginseng crosses 150 meshes.
Parch uses LZ300L type Chinese medicine frying machine in step 3, crushes and uses DLF-28 Chinese medicine material crushing machine.
Poria cocos, rheum officinale, endothelium corneum gigeriae galli, centipede, fructus amomi and Medicated Leaven parch time are 0.5~1h, rhizoma alismatis, pheretima in step 3
It is 1~1.5h with the leech parch time.
The ethanol consumption filtered for the first time in step 4 is 5~8 times of coarse powder gross mass, the ethanol consumption of second of alcohol extracting
It is 3~5 times of coarse powder gross mass.
Ethyl alcohol in step 4 be extracted as refluxing extraction, diafiltration extract, Soakage extraction it is any.
Concentration can be any of normal pressure concentration, reduced pressure and film concentration in step 4.
The canned of capsule is canned, semi-automatic canned, automatic canning any by hand in step 5.
The beneficial effects of the present invention are: present invention ginseng sweet temperature, reinforces vital energy as monarch drug in a prescription；The secret lean of fermentation cordyceps
Gas, Poria cocos invigorating the spleen dehumidifying, principal drug assistance nourishing spleen kidney is ministerial drug altogether；Rheum officinale leads to internal organs and rushes down turbid, and cult poison is promoted to reach outside internal organs；Rhizoma alismatis Li Shui
Excreting dampness, leech, pheretima, centipede activating microcirculation and removing stasis medicinal, degrading the channel, it is altogether adjutant that blood then pass through by water row, advantageous water-wet；Fructus amomi, six minds
Bent, endothelium corneum gigeriae galli strengthening the spleen and stomach, disperse accumulation Li Shui are to make medicine.All medicine phases 5, play replenish qi to invigorate the spleen altogether, and warm kidney consolidates, the function of activating blood and promoting diuresis.
Specific embodiment
The present invention is described in detail With reference to embodiment.
A kind of Chinese medicine composition of invigorating the spleen warm kidney of the present invention, composed of the following components by weight percentage: ginseng 6~8%,
Fermentation cordyceps 4~7%, Poria cocos 12~15%, rheum officinale 6~10%, rhizoma alismatis 10~12%, endothelium corneum gigeriae galli 10~13%, pheretima 4
~7%, leech 10~13%, centipede 4~6%, fructus amomi 5~7%, Medicated Leaven 11~25%, the weight percent of the above each component
It is 100% than summation.
A kind of preparation method of the Chinese medicine composition of invigorating the spleen warm kidney of the present invention, includes the following steps specific implementation:
Step 1 weighs ginseng 6~8% according to weight percent respectively, fermentation cordyceps 4~7%, and Poria cocos 12~
15%, rheum officinale 6~10%, rhizoma alismatis 10~12%, endothelium corneum gigeriae galli 10~13%, pheretima 4~7%, leech 10~13%, centipede 4~
6%, fructus amomi 5~7%, Medicated Leaven 11~25%, the weight percent summation of the above each component is 100%.
Step 2 sieves with 100 mesh sieve the weighed fermentation cordyceps of step 1, and ginseng is dried and ground, and 150 are crossed after grinding
Mesh.Drying uses heat pump ginseng dryer, and drying temperature is 70~85 DEG C, and drying time is 10~15 hours, dries power
For 3kW~5kW, grinding uses XDW-F100 micronizer.
Step 3, by the weighed Poria cocos of step 1, rheum officinale, rhizoma alismatis, endothelium corneum gigeriae galli, pheretima, leech, centipede, fructus amomi and Medicated Leaven
It is sent into LZ300L type Chinese medicine frying machine in batches, parch is crushed, after crushing to parching completely using DLF-28 Chinese medicine material crushing machine
Cross 50 meshes.Poria cocos, rheum officinale, endothelium corneum gigeriae galli, centipede, fructus amomi and Medicated Leaven the parch time be 0.5~1h, rhizoma alismatis, pheretima and
The parch time of leech is 1~1.5h.
Coarse powder obtained in step 3 is uniformly mixed by step 4, and 40~80% ethyl alcohol of above-mentioned mixed powder is extracted 2 times
And filter, filtrate is concentrated to give liquid extract, dry obtained dried cream powder.The ethanol consumption of filtering is the 5~8 of coarse powder gross mass for the first time
Times, the ethanol consumption of second of alcohol extracting is 3~5 times of coarse powder gross mass,
Ginseng fine powder and fermentation cordyceps that dried cream powder that step 4 obtains and step 2 obtain are uniformly mixed by step 5,
Encapsulating capsule to obtain the final product.
Ethyl alcohol in step 4 be extracted as refluxing extraction, diafiltration extract, Soakage extraction it is any.
Concentration can be any of normal pressure concentration, reduced pressure and film concentration in step 4.
The canned of capsule is canned, semi-automatic canned, automatic canning any by hand in step 5.
Function of the various raw materials of the present invention in Chinese medicine composition is: we's ginseng sweet temperature is reinforced vital energy as monarch drug in a prescription；
The secret lean gas of fermentation cordyceps, Poria cocos invigorating the spleen dehumidifying, principal drug assistance nourishing spleen kidney is ministerial drug altogether；Rheum officinale leads to internal organs and rushes down turbid, promotes heresy
Poison reaches outside internal organs；Rhizoma alismatis clearing damp and promoting diuresis, leech, pheretima, centipede activating microcirculation and removing stasis medicinal, degrading the channel, then water row, advantageous water-wet are logical for blood
Row, is altogether adjutant；Fructus amomi, Medicated Leaven, endothelium corneum gigeriae galli strengthening the spleen and stomach, disperse accumulation Li Shui are to make medicine.All medicine phases 5, play replenish qi to invigorate the spleen altogether,
Warm kidney consolidates, the function of activating blood and promoting diuresis.
The present invention is major function: replenish qi to invigorate the spleen, and warm kidney consolidates, activating blood and promoting diuresis.Cure mainly limb caused by speen-kidney dificiency, water-wet stasis blocking
Body oedema, oliguria, turbid urine receive poor out of strength, soreness and weakness of waist and knees, and aversion to cold and cold limbs, tongue is dark red or light fat, and whitish tongue is greasy, slow and sunken pulse it is powerless or
It is carefully puckery etc..Acute and chronic nephritis, nephrotic syndrome, pyelonephritis are shown in above-mentioned card marquis person.
Usage and dosage of the invention: oral meal, one time 3~5,3 times a day.Children cut down according to the circumstance or follow the doctor's advice, and are within 6 months
One course for the treatment of.
The present invention treats chronic nephritis, and card belongs to speen-kidney dificiency, and the clinical observation of water-wet blood stasis blocking type shows to treat total effective rate
90%, illustrate that the traditional chinese medicine composition of the invention is effective in cure when treating chronic nephritis, can be relieved clinical symptoms, some patientss make to urinate egg
It is white to turn out cloudy, while reducing BUN, Scr.Obvious toxicity is not found in test, illustrates that the medicine clinic trial is safe and effective.
Embodiment 1
A kind of preparation method of the Chinese medicine composition of invigorating the spleen warm kidney of the present invention, includes the following steps specific implementation:
Step 1 weighs ginseng 6% according to weight percent respectively, fermentation cordyceps 4%, Poria cocos 12%, rheum officinale 6%,
Rhizoma alismatis 10%, endothelium corneum gigeriae galli 10%, pheretima 7%, leech 10%, centipede 5%, fructus amomi 5%, Medicated Leaven 25%, the above each component
Weight percent summation is 100%.
Step 2 sieves with 100 mesh sieve the weighed fermentation cordyceps of step 1, and ginseng is dried and ground, and 150 are crossed after grinding
Mesh.Drying uses heat pump ginseng dryer, and drying temperature is 70 DEG C, and drying time is 10 hours, and drying power is 3kW, grinds
Mill uses XDW-F100 micronizer.
Step 3, by the weighed Poria cocos of step 1, rheum officinale, rhizoma alismatis, endothelium corneum gigeriae galli, pheretima, leech, centipede, fructus amomi and Medicated Leaven
It is sent into LZ300L type Chinese medicine frying machine in batches, parch is crushed, after crushing to parching completely using DLF-28 Chinese medicine material crushing machine
Cross 50 meshes.Poria cocos, rheum officinale, endothelium corneum gigeriae galli, centipede, fructus amomi and Medicated Leaven parch time are 0.5h, rhizoma alismatis, pheretima and leech parch
Time is 1h.
Coarse powder obtained in step 3 is uniformly mixed by step 4, and 40% alcohol reflux of above-mentioned mixed powder is extracted 2 times
And filter, filtrate is concentrated to give liquid extract, dry obtained dried cream powder through normal pressure.The ethanol consumption of filtering is coarse powder gross mass for the first time
5 times, the ethanol consumption of second of alcohol extracting is 3 times of coarse powder gross mass.
Ginseng fine powder and fermentation cordyceps that dried cream powder that step 4 obtains and step 2 obtain are uniformly mixed by step 5,
Using canned mode encapsulating capsule by hand to obtain the final product.
Embodiment 2
A kind of preparation method of the Chinese medicine composition of invigorating the spleen warm kidney of the present invention, includes the following steps specific implementation:
Step 1 weighs ginseng 7% according to weight percent respectively, fermentation cordyceps 5%, Poria cocos 13%, rheum officinale 6%,
Rhizoma alismatis 11%, endothelium corneum gigeriae galli 10%, pheretima 4%, leech 10%, centipede 6%, fructus amomi 6%, Medicated Leaven 22%, the above each component
Weight percent summation is 100%.
Step 2 sieves with 100 mesh sieve the weighed fermentation cordyceps of step 1, and ginseng is dried and ground, and 150 are crossed after grinding
Mesh.Drying uses heat pump ginseng dryer, and drying temperature is 75 DEG C, and drying time is 12 hours, and drying power is 3kW, grinds
Mill uses XDW-F100 micronizer.
Step 3, by the weighed Poria cocos of step 1, rheum officinale, rhizoma alismatis, endothelium corneum gigeriae galli, pheretima, leech, centipede, fructus amomi and Medicated Leaven
It is sent into LZ300L type Chinese medicine frying machine in batches, parch is crushed, after crushing to parching completely using DLF-28 Chinese medicine material crushing machine
Cross 50 meshes.Poria cocos, rheum officinale, endothelium corneum gigeriae galli, centipede, fructus amomi and Medicated Leaven parch time are 45min, and rhizoma alismatis, pheretima and leech are dried
The stir-fry time is 80min.
Coarse powder obtained in step 3 is uniformly mixed by step 4, and 40% ethanol percolation of above-mentioned mixed powder is extracted 2 times
And filter, liquid extract, dry obtained dried cream powder is concentrated under reduced pressure to obtain in filtrate.The ethanol consumption of filtering is coarse powder gross mass for the first time
6 times, the ethanol consumption of second of alcohol extracting is 4 times of coarse powder gross mass.
Ginseng fine powder and fermentation cordyceps that dried cream powder that step 4 obtains and step 2 obtain are uniformly mixed by step 5,
Using semi-automatic canned mode encapsulating capsule to obtain the final product.
Embodiment 3
A kind of preparation method of the Chinese medicine composition of invigorating the spleen warm kidney of the present invention, includes the following steps specific implementation:
Step 1 weighs ginseng 8% according to weight percent respectively, fermentation cordyceps 7%, Poria cocos 13%, rheum officinale 8%,
Rhizoma alismatis 12%, endothelium corneum gigeriae galli 13%, pheretima 5%, leech 10%, centipede 5%, fructus amomi 5%, Medicated Leaven 14%, the above each component
Weight percent summation is 100%.
Step 2 sieves with 100 mesh sieve the weighed fermentation cordyceps of step 1, and ginseng is dried and ground, and 150 are crossed after grinding
Mesh.Drying uses heat pump ginseng dryer, and drying temperature is 80 DEG C, and drying time is 14 hours, and drying power is 4kW, grinds
Mill uses XDW-F100 micronizer.
Step 3, by the weighed Poria cocos of step 1, rheum officinale, rhizoma alismatis, endothelium corneum gigeriae galli, pheretima, leech, centipede, fructus amomi and Medicated Leaven
It is sent into LZ300L type Chinese medicine frying machine in batches, parch is crushed, after crushing to parching completely using DLF-28 Chinese medicine material crushing machine
Cross 50 meshes.Poria cocos, rheum officinale, endothelium corneum gigeriae galli, centipede, fructus amomi and Medicated Leaven parch time are 1h, when rhizoma alismatis, pheretima and leech parch
Between be 1.5h.
Coarse powder obtained in step 3 is uniformly mixed by step 4, and 80% alcohol dipping of above-mentioned mixed powder is extracted 2 times
And filter, filtrate is concentrated to give liquid extract, dry obtained dried cream powder through film.The ethanol consumption of filtering is coarse powder gross mass for the first time
8 times, the ethanol consumption of second of alcohol extracting is 5 times of coarse powder gross mass.
Ginseng fine powder and fermentation cordyceps that dried cream powder that step 4 obtains and step 2 obtain are uniformly mixed by step 5,
Using automatic canning mode encapsulating capsule to obtain the final product.
Embodiment 4
A kind of preparation method of the Chinese medicine composition of invigorating the spleen warm kidney of the present invention, includes the following steps specific implementation:
Step 1 weighs ginseng 6% according to weight percent respectively, fermentation cordyceps 7%, Poria cocos 14%, rheum officinale 9%,
Rhizoma alismatis 12%, endothelium corneum gigeriae galli 13%, pheretima 4%, leech 13%, centipede 4%, fructus amomi 7%, Medicated Leaven 11%, the above each component
Weight percent summation is 100%.
Step 2 sieves with 100 mesh sieve the weighed fermentation cordyceps of step 1, and ginseng is dried and ground, and 150 are crossed after grinding
Mesh.Drying uses heat pump ginseng dryer, and drying temperature is 80 DEG C, and drying time is 14 hours, and drying power is 5kW, grinds
Mill uses XDW-F100 micronizer.
Step 3, by the weighed Poria cocos of step 1, rheum officinale, rhizoma alismatis, endothelium corneum gigeriae galli, pheretima, leech, centipede, fructus amomi and Medicated Leaven
It is sent into LZ300L type Chinese medicine frying machine in batches, parch is crushed, after crushing to parching completely using DLF-28 Chinese medicine material crushing machine
Cross 50 meshes.Poria cocos, rheum officinale, endothelium corneum gigeriae galli, centipede, fructus amomi and Medicated Leaven parch time are 1h, when rhizoma alismatis, pheretima and leech parch
Between be 1.5h.
Coarse powder obtained in step 3 is uniformly mixed by step 4, and 80% ethanol percolation of above-mentioned mixed powder is extracted 2 times
And filter, liquid extract, dry obtained dried cream powder is concentrated under reduced pressure to obtain in filtrate.The ethanol consumption of filtering is coarse powder gross mass for the first time
8 times, the ethanol consumption of second of alcohol extracting is 5 times of coarse powder gross mass.
Ginseng fine powder and fermentation cordyceps that dried cream powder that step 4 obtains and step 2 obtain are uniformly mixed by step 5,
Using automatic canning mode encapsulating capsule to obtain the final product.
Claims (10)
1. a kind of Chinese medicine composition of invigorating the spleen warm kidney, which is characterized in that composed of the following components by weight percentage: ginseng 6~
8%, fermentation cordyceps 4~7%, Poria cocos 12~15%, rheum officinale 6~10%, rhizoma alismatis 10~12%, endothelium corneum gigeriae galli 10~13%,
Pheretima 4~7%, leech 10~13%, centipede 4~6%, fructus amomi 5~7%, Medicated Leaven 11~25%, the weight of the above each component
Percentage summation is 100%.
2. a kind of preparation method of the Chinese medicine composition of invigorating the spleen warm kidney, which is characterized in that include the following steps specific implementation:
Step 1 weighs ginseng 6~8% according to weight percent respectively, fermentation cordyceps 4~7%, Poria cocos 12~15%, greatly
Huang 6~10%, rhizoma alismatis 10~12%, endothelium corneum gigeriae galli 10~13%, pheretima 4~7%, leech 10~13%, centipede 4~6%, fructus amomi
5~7%, Medicated Leaven 11~25%, the weight percent summation of the above each component is 100%；
The weighed fermentation cordyceps of step 1 are sieved by step 2, and ginseng is dried and ground, is sieved after grinding；
Step 3, by the weighed Poria cocos of step 1, rheum officinale, rhizoma alismatis, endothelium corneum gigeriae galli, pheretima, leech, centipede, fructus amomi and Medicated Leaven in batches
Parch, parch crush to parching completely, smash it through 50 meshes, obtain coarse powder；
Coarse powder obtained in step 3 is uniformly mixed by step 4, and mixed powder is extracted 2 times and filtered with 40~80% ethyl alcohol,
Filtrate is concentrated to give liquid extract, dry obtained dried cream powder；
Ginseng fine powder and fermentation cordyceps that dried cream powder that step 4 obtains and step 2 obtain are uniformly mixed, encapsulating by step 5
Capsule to obtain the final product.
3. a kind of preparation method of the Chinese medicine composition of invigorating the spleen warm kidney as claimed in claim 2, which is characterized in that the step
Drying uses heat pump ginseng dryer in 2, and drying temperature is 70~85 DEG C, and drying time is 10~15 hours, and drying power is
3kW~5kW, grinding use XDW-F100 micronizer.
4. a kind of preparation method of the Chinese medicine composition of invigorating the spleen warm kidney as claimed in claim 2, which is characterized in that the step
Fermentation cordyceps sieve with 100 mesh sieve in 2, and ginseng crosses 150 meshes.
5. a kind of preparation method of the Chinese medicine composition of invigorating the spleen warm kidney as claimed in claim 2, which is characterized in that the step
Parch uses LZ300L type Chinese medicine frying machine in 3, crushes and uses DLF-28 Chinese medicine material crushing machine.
6. a kind of preparation method of the Chinese medicine composition of invigorating the spleen warm kidney as claimed in claim 2, which is characterized in that the step
Poria cocos, rheum officinale, endothelium corneum gigeriae galli, centipede, fructus amomi and Medicated Leaven parch time are 0.5~1h in 3, when rhizoma alismatis, pheretima and leech parch
Between be 1~1.5h.
7. a kind of preparation method of the Chinese medicine composition of invigorating the spleen warm kidney as claimed in claim 2, which is characterized in that the step
The ethanol consumption filtered for the first time in 4 is 5~8 times of coarse powder gross mass, and the ethanol consumption of second of alcohol extracting is coarse powder gross mass
3~5 times.
8. a kind of preparation method of the Chinese medicine composition of invigorating the spleen warm kidney as claimed in claim 2, which is characterized in that the step
Ethyl alcohol in 4 be extracted as refluxing extraction, diafiltration extract, Soakage extraction it is any.
9. a kind of preparation method of the Chinese medicine composition of invigorating the spleen warm kidney as claimed in claim 2, which is characterized in that the step
Concentration can be any of normal pressure concentration, reduced pressure and film concentration in 4.
10. a kind of preparation method of the Chinese medicine composition of invigorating the spleen warm kidney as claimed in claim 2, which is characterized in that the step
The canned of capsule is canned, semi-automatic canned, automatic canning any by hand in rapid 5.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114010713A (en) * | 2021-06-02 | 2022-02-08 | 陈凤羽 | Kidney failure recovery pill |
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| CN101129489A (en) * | 2007-08-16 | 2008-02-27 | 江苏信孚药业有限公司 | Compound kidney reinforcing patch |
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| CN101129489A (en) * | 2007-08-16 | 2008-02-27 | 江苏信孚药业有限公司 | Compound kidney reinforcing patch |
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| 李楠: "肾益康胶囊对脾肾气虚型慢性肾小球肾炎疗效及血脂变化的影响", 《光明中医》 * |
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Application publication date: 20190823 |