CN1953974A - 治疗异常细胞生长的嘧啶衍生物 - Google Patents
治疗异常细胞生长的嘧啶衍生物 Download PDFInfo
- Publication number
- CN1953974A CN1953974A CNA2005800155302A CN200580015530A CN1953974A CN 1953974 A CN1953974 A CN 1953974A CN A2005800155302 A CNA2005800155302 A CN A2005800155302A CN 200580015530 A CN200580015530 A CN 200580015530A CN 1953974 A CN1953974 A CN 1953974A
- Authority
- CN
- China
- Prior art keywords
- amino
- methyl
- base
- alkyl
- pyrimidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57131204P | 2004-05-14 | 2004-05-14 | |
| US60/571,312 | 2004-05-14 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011100212904A Division CN102127058A (zh) | 2004-05-14 | 2005-05-02 | 治疗异常细胞生长的嘧啶衍生物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1953974A true CN1953974A (zh) | 2007-04-25 |
Family
ID=34966230
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2005800155302A Pending CN1953974A (zh) | 2004-05-14 | 2005-05-02 | 治疗异常细胞生长的嘧啶衍生物 |
| CN2011100212904A Pending CN102127058A (zh) | 2004-05-14 | 2005-05-02 | 治疗异常细胞生长的嘧啶衍生物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011100212904A Pending CN102127058A (zh) | 2004-05-14 | 2005-05-02 | 治疗异常细胞生长的嘧啶衍生物 |
Country Status (27)
| Country | Link |
|---|---|
| EP (1) | EP1751143A1 (nl) |
| JP (1) | JP4099212B2 (nl) |
| KR (1) | KR100886990B1 (nl) |
| CN (2) | CN1953974A (nl) |
| AP (1) | AP2241A (nl) |
| AR (1) | AR049097A1 (nl) |
| AU (2) | AU2005243397A1 (nl) |
| BR (1) | BRPI0511138A (nl) |
| CA (1) | CA2566707A1 (nl) |
| CR (1) | CR8749A (nl) |
| EA (1) | EA200601796A1 (nl) |
| EC (1) | ECSP066997A (nl) |
| GE (1) | GEP20104875B (nl) |
| GT (1) | GT200500113A (nl) |
| IL (1) | IL178828A0 (nl) |
| MA (1) | MA28583B1 (nl) |
| MX (1) | MXPA06011890A (nl) |
| NL (2) | NL1029045C2 (nl) |
| NO (1) | NO20064576L (nl) |
| NZ (1) | NZ550448A (nl) |
| PA (1) | PA8632601A1 (nl) |
| PE (1) | PE20060240A1 (nl) |
| TN (1) | TNSN06370A1 (nl) |
| TW (1) | TWI303635B (nl) |
| UY (1) | UY28894A1 (nl) |
| WO (1) | WO2005111023A1 (nl) |
| ZA (1) | ZA200608394B (nl) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102448943A (zh) * | 2009-05-29 | 2012-05-09 | 贝林格尔.英格海姆国际有限公司 | 用于治疗特征在于过度或异常细胞增殖的疾病的2,4-二氨基嘧啶 |
| CN103951658A (zh) * | 2007-04-18 | 2014-07-30 | 辉瑞产品公司 | 用于治疗异常细胞生长的磺酰胺衍生物 |
| CN109608444A (zh) * | 2018-11-27 | 2019-04-12 | 中国药科大学 | 含异吲哚啉酮的erk抑制剂及其制备方法与用途 |
| CN111732548A (zh) * | 2020-06-11 | 2020-10-02 | 浙江大学 | N2-氨甲酰芳环-2-氨基嘧啶类衍生物及其医药用途 |
| WO2024140671A1 (zh) * | 2022-12-29 | 2024-07-04 | 南京昕瑞再生医药科技有限公司 | 一种稠三环类衍生物、包含其的药物组合物及其用途 |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2566531A1 (en) * | 2004-05-18 | 2005-12-15 | Rigel Pharmaceuticals, Inc. | Cycloalkyl substituted pyrimidinediamine compounds and their uses |
| US20070032514A1 (en) * | 2005-07-01 | 2007-02-08 | Zahn Stephan K | 2,4-diamino-pyrimidines as aurora inhibitors |
| KR101060051B1 (ko) * | 2005-12-21 | 2011-08-29 | 화이자 프로덕츠 인크. | 비정상적인 세포 성장을 치료하기 위한 피리미딘 유도체 |
| EP2183225A1 (en) * | 2007-07-17 | 2010-05-12 | Rigel Pharmaceuticals, Inc. | Cyclic amine substituted pyrimidinediamines as pkc inhibitors |
| EP2231620A1 (en) * | 2007-12-03 | 2010-09-29 | Boehringer Ingelheim International GmbH | Diaminopyridines for the treatment of diseases which are characterised by excessive or anomal cell proliferation |
| EA029131B1 (ru) * | 2008-05-21 | 2018-02-28 | Ариад Фармасьютикалз, Инк. | Фосфорсодержащие производные в качестве ингибиторов киназы |
| JP5539518B2 (ja) | 2009-08-14 | 2014-07-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ２−アミノ−５−トリフルオロメチルピリミジン誘導体の位置選択的調製 |
| US8933227B2 (en) | 2009-08-14 | 2015-01-13 | Boehringer Ingelheim International Gmbh | Selective synthesis of functionalized pyrimidines |
| US20120244141A1 (en) | 2010-09-28 | 2012-09-27 | Boehringer Ingelheim International Gmbh | Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors |
| WO2014174745A1 (ja) * | 2013-04-26 | 2014-10-30 | 国立大学法人京都大学 | Ｅｇ５阻害剤 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9721437D0 (en) * | 1997-10-10 | 1997-12-10 | Glaxo Group Ltd | Heteroaromatic compounds and their use in medicine |
| AR042586A1 (es) | 2001-02-15 | 2005-06-29 | Sugen Inc | 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa |
| WO2003030909A1 (en) * | 2001-09-25 | 2003-04-17 | Bayer Pharmaceuticals Corporation | 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer |
| PT1625121E (pt) * | 2002-12-20 | 2010-03-11 | Pfizer Prod Inc | Derivados de piridina para o tratamento de crescimento celular anormal |
| UA80767C2 (en) * | 2002-12-20 | 2007-10-25 | Pfizer Prod Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
-
2005
- 2005-05-02 MX MXPA06011890A patent/MXPA06011890A/es unknown
- 2005-05-02 KR KR1020067023767A patent/KR100886990B1/ko active IP Right Grant
- 2005-05-02 NZ NZ550448A patent/NZ550448A/en unknown
- 2005-05-02 BR BRPI0511138-2A patent/BRPI0511138A/pt not_active IP Right Cessation
- 2005-05-02 AU AU2005243397A patent/AU2005243397A1/en not_active Abandoned
- 2005-05-02 CN CNA2005800155302A patent/CN1953974A/zh active Pending
- 2005-05-02 CN CN2011100212904A patent/CN102127058A/zh active Pending
- 2005-05-02 AP AP2006003790A patent/AP2241A/xx active
- 2005-05-02 EA EA200601796A patent/EA200601796A1/ru unknown
- 2005-05-02 CA CA002566707A patent/CA2566707A1/en not_active Abandoned
- 2005-05-02 WO PCT/IB2005/001201 patent/WO2005111023A1/en active Application Filing
- 2005-05-02 EP EP05732043A patent/EP1751143A1/en not_active Withdrawn
- 2005-05-02 JP JP2007512557A patent/JP4099212B2/ja active Active
- 2005-05-02 GE GEAP20059703A patent/GEP20104875B/en unknown
- 2005-05-11 PA PA20058632601A patent/PA8632601A1/es unknown
- 2005-05-11 TW TW094115237A patent/TWI303635B/zh active
- 2005-05-12 UY UY28894A patent/UY28894A1/es not_active Application Discontinuation
- 2005-05-12 PE PE2005000534A patent/PE20060240A1/es not_active Application Discontinuation
- 2005-05-13 GT GT200500113A patent/GT200500113A/es unknown
- 2005-05-13 AR ARP050101969A patent/AR049097A1/es not_active Application Discontinuation
- 2005-05-13 NL NL1029045A patent/NL1029045C2/nl active Search and Examination
-
2006
- 2006-05-19 NL NL1031845A patent/NL1031845C2/nl active Search and Examination
- 2006-10-06 ZA ZA200608394A patent/ZA200608394B/xx unknown
- 2006-10-09 NO NO20064576A patent/NO20064576L/no not_active Application Discontinuation
- 2006-10-23 IL IL178828A patent/IL178828A0/en unknown
- 2006-11-13 EC EC2006006997A patent/ECSP066997A/es unknown
- 2006-11-13 CR CR8749A patent/CR8749A/es not_active Application Discontinuation
- 2006-11-13 TN TNP2006000370A patent/TNSN06370A1/fr unknown
- 2006-11-14 MA MA29452A patent/MA28583B1/fr unknown
-
2009
- 2009-11-13 AU AU2009238255A patent/AU2009238255A1/en not_active Ceased
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103951658A (zh) * | 2007-04-18 | 2014-07-30 | 辉瑞产品公司 | 用于治疗异常细胞生长的磺酰胺衍生物 |
| CN103951658B (zh) * | 2007-04-18 | 2017-10-13 | 辉瑞产品公司 | 用于治疗异常细胞生长的磺酰胺衍生物 |
| CN102448943A (zh) * | 2009-05-29 | 2012-05-09 | 贝林格尔.英格海姆国际有限公司 | 用于治疗特征在于过度或异常细胞增殖的疾病的2,4-二氨基嘧啶 |
| CN109608444A (zh) * | 2018-11-27 | 2019-04-12 | 中国药科大学 | 含异吲哚啉酮的erk抑制剂及其制备方法与用途 |
| CN109608444B (zh) * | 2018-11-27 | 2022-02-11 | 中国药科大学 | 含异吲哚啉酮的erk抑制剂及其制备方法与用途 |
| CN111732548A (zh) * | 2020-06-11 | 2020-10-02 | 浙江大学 | N2-氨甲酰芳环-2-氨基嘧啶类衍生物及其医药用途 |
| CN111732548B (zh) * | 2020-06-11 | 2022-06-17 | 浙江大学 | N2-氨甲酰芳环-2-氨基嘧啶类衍生物及其医药用途 |
| WO2024140671A1 (zh) * | 2022-12-29 | 2024-07-04 | 南京昕瑞再生医药科技有限公司 | 一种稠三环类衍生物、包含其的药物组合物及其用途 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1105203 Country of ref document: HK |
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| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Open date: 20070425 |
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