CN1951962B - 用于制备抗肿瘤抗体的多肽及其应用 - Google Patents
用于制备抗肿瘤抗体的多肽及其应用 Download PDFInfo
- Publication number
- CN1951962B CN1951962B CN2005101091314A CN200510109131A CN1951962B CN 1951962 B CN1951962 B CN 1951962B CN 2005101091314 A CN2005101091314 A CN 2005101091314A CN 200510109131 A CN200510109131 A CN 200510109131A CN 1951962 B CN1951962 B CN 1951962B
- Authority
- CN
- China
- Prior art keywords
- antibody
- tumor
- monoclonal antibody
- polypeptide
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 27
- 229920001184 polypeptide Polymers 0.000 title claims abstract description 24
- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 24
- 230000000118 anti-neoplastic effect Effects 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 97
- 239000003814 drug Substances 0.000 claims abstract description 19
- 238000011282 treatment Methods 0.000 claims description 35
- 230000000259 anti-tumor effect Effects 0.000 claims description 15
- 230000008878 coupling Effects 0.000 claims description 15
- 238000010168 coupling process Methods 0.000 claims description 15
- 238000005859 coupling reaction Methods 0.000 claims description 15
- 206010009944 Colon cancer Diseases 0.000 claims description 13
- 208000029742 colonic neoplasm Diseases 0.000 claims description 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 8
- 241001597008 Nomeidae Species 0.000 claims description 7
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 5
- 229940126619 mouse monoclonal antibody Drugs 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 3
- 230000005764 inhibitory process Effects 0.000 claims description 2
- 229940002612 prodrug Drugs 0.000 claims description 2
- 239000000651 prodrug Substances 0.000 claims description 2
- 238000012546 transfer Methods 0.000 claims description 2
- 229940079593 drug Drugs 0.000 abstract description 8
- 239000002773 nucleotide Substances 0.000 abstract description 2
- 125000003729 nucleotide group Chemical group 0.000 abstract description 2
- 239000003124 biologic agent Substances 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 description 46
- 102000036639 antigens Human genes 0.000 description 46
- 239000000427 antigen Substances 0.000 description 43
- 241000282414 Homo sapiens Species 0.000 description 31
- 238000000034 method Methods 0.000 description 17
- 210000004881 tumor cell Anatomy 0.000 description 14
- 201000011510 cancer Diseases 0.000 description 11
- 238000002372 labelling Methods 0.000 description 9
- 238000002360 preparation method Methods 0.000 description 9
- 108090000623 proteins and genes Proteins 0.000 description 9
- 230000000694 effects Effects 0.000 description 8
- 102000004169 proteins and genes Human genes 0.000 description 8
- 241000699670 Mus sp. Species 0.000 description 7
- 230000008569 process Effects 0.000 description 7
- 235000018102 proteins Nutrition 0.000 description 7
- 241001465754 Metazoa Species 0.000 description 6
- 230000000890 antigenic effect Effects 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 6
- 230000002401 inhibitory effect Effects 0.000 description 6
- 238000002347 injection Methods 0.000 description 6
- 239000007924 injection Substances 0.000 description 6
- 238000011160 research Methods 0.000 description 6
- 239000012528 membrane Substances 0.000 description 5
- 238000002626 targeted therapy Methods 0.000 description 5
- 230000004614 tumor growth Effects 0.000 description 5
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 description 4
- 108700020796 Oncogene Proteins 0.000 description 4
- 125000000539 amino acid group Chemical group 0.000 description 4
- 238000002512 chemotherapy Methods 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 229960003297 gemtuzumab ozogamicin Drugs 0.000 description 4
- 230000036039 immunity Effects 0.000 description 4
- 238000001727 in vivo Methods 0.000 description 4
- 239000006249 magnetic particle Substances 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 102100030438 Derlin-1 Human genes 0.000 description 3
- 101710178882 Derlin-1 Proteins 0.000 description 3
- 238000002965 ELISA Methods 0.000 description 3
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 3
- 240000002853 Nelumbo nucifera Species 0.000 description 3
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 3
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 3
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 description 3
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 3
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 3
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 3
- 229940125644 antibody drug Drugs 0.000 description 3
- 239000012636 effector Substances 0.000 description 3
- 210000002472 endoplasmic reticulum Anatomy 0.000 description 3
- 238000002649 immunization Methods 0.000 description 3
- 230000003053 immunization Effects 0.000 description 3
- 238000011580 nude mouse model Methods 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 208000031261 Acute myeloid leukaemia Diseases 0.000 description 2
- 206010006187 Breast cancer Diseases 0.000 description 2
- 208000026310 Breast neoplasm Diseases 0.000 description 2
- 102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 description 2
- 102100039607 Erlin-1 Human genes 0.000 description 2
- 206010025323 Lymphomas Diseases 0.000 description 2
- 206010027336 Menstruation delayed Diseases 0.000 description 2
- 101710188053 Protein D Proteins 0.000 description 2
- 101710132893 Resolvase Proteins 0.000 description 2
- 210000000683 abdominal cavity Anatomy 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 230000001093 anti-cancer Effects 0.000 description 2
- 230000003302 anti-idiotype Effects 0.000 description 2
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 229950003145 apolizumab Drugs 0.000 description 2
- 201000008275 breast carcinoma Diseases 0.000 description 2
- 208000035269 cancer or benign tumor Diseases 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 229960001776 edrecolomab Drugs 0.000 description 2
- 229950009760 epratuzumab Drugs 0.000 description 2
- 101150017104 erlin1 gene Proteins 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 230000005847 immunogenicity Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- 238000002625 monoclonal antibody therapy Methods 0.000 description 2
- 208000025113 myeloid leukemia Diseases 0.000 description 2
- 210000004988 splenocyte Anatomy 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 230000008685 targeting Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000004809 thin layer chromatography Methods 0.000 description 2
- 230000005748 tumor development Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- FFILOTSTFMXQJC-QCFYAKGBSA-N (2r,4r,5s,6s)-2-[3-[(2s,3s,4r,6s)-6-[(2s,3r,4r,5s,6r)-5-[(2s,3r,4r,5r,6r)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-[(2r,3s,4r,5r,6r)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(e)-3-hydroxy-2-(octadecanoylamino)octadec-4-enoxy]oxan-3-yl]oxy-3-hy Chemical compound O[C@@H]1[C@@H](O)[C@H](OCC(NC(=O)CCCCCCCCCCCCCCCCC)C(O)\C=C\CCCCCCCCCCCCC)O[C@H](CO)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@]2(O[C@@H]([C@@H](N)[C@H](O)C2)C(O)C(O)CO[C@]2(O[C@@H]([C@@H](N)[C@H](O)C2)C(O)C(O)CO)C(O)=O)C(O)=O)[C@@H](O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](CO)O1 FFILOTSTFMXQJC-QCFYAKGBSA-N 0.000 description 1
- RTQWWZBSTRGEAV-PKHIMPSTSA-N 2-[[(2s)-2-[bis(carboxymethyl)amino]-3-[4-(methylcarbamoylamino)phenyl]propyl]-[2-[bis(carboxymethyl)amino]propyl]amino]acetic acid Chemical compound CNC(=O)NC1=CC=C(C[C@@H](CN(CC(C)N(CC(O)=O)CC(O)=O)CC(O)=O)N(CC(O)=O)CC(O)=O)C=C1 RTQWWZBSTRGEAV-PKHIMPSTSA-N 0.000 description 1
- 102400000068 Angiostatin Human genes 0.000 description 1
- 108010079709 Angiostatins Proteins 0.000 description 1
- QEHMMRSQJMOYNO-DCAQKATOSA-N Arg-His-Asn Chemical compound C1=C(NC=N1)C[C@@H](C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)N QEHMMRSQJMOYNO-DCAQKATOSA-N 0.000 description 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 description 1
- 102100038080 B-cell receptor CD22 Human genes 0.000 description 1
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 description 1
- 102100024217 CAMPATH-1 antigen Human genes 0.000 description 1
- 108010065524 CD52 Antigen Proteins 0.000 description 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 102000001301 EGF receptor Human genes 0.000 description 1
- 108060006698 EGF receptor Proteins 0.000 description 1
- 102100037241 Endoglin Human genes 0.000 description 1
- 108010036395 Endoglin Proteins 0.000 description 1
- 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 description 1
- 102100031706 Fibroblast growth factor 1 Human genes 0.000 description 1
- FXLVSYVJDPCIHH-STQMWFEESA-N Gly-Phe-Arg Chemical compound [H]NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O FXLVSYVJDPCIHH-STQMWFEESA-N 0.000 description 1
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 description 1
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 description 1
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 description 1
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 description 1
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 description 1
- 102000008100 Human Serum Albumin Human genes 0.000 description 1
- 108091006905 Human Serum Albumin Proteins 0.000 description 1
- -1 IGN-101 Chemical compound 0.000 description 1
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 description 1
- LAPSXOAUPNOINL-YUMQZZPRSA-N Leu-Gly-Asp Chemical compound CC(C)C[C@H](N)C(=O)NCC(=O)N[C@H](C(O)=O)CC(O)=O LAPSXOAUPNOINL-YUMQZZPRSA-N 0.000 description 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 description 1
- 206010025280 Lymphocytosis Diseases 0.000 description 1
- 208000004059 Male Breast Neoplasms Diseases 0.000 description 1
- 108010052285 Membrane Proteins Proteins 0.000 description 1
- 102000018697 Membrane Proteins Human genes 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 description 1
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241000237988 Patellidae Species 0.000 description 1
- 235000012012 Paullinia yoco Nutrition 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 208000015634 Rectal Neoplasms Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 102100025237 T-cell surface antigen CD2 Human genes 0.000 description 1
- SVGAWGVHFIYAEE-JSGCOSHPSA-N Trp-Gly-Gln Chemical compound C1=CC=C2C(C[C@H](N)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(O)=O)=CNC2=C1 SVGAWGVHFIYAEE-JSGCOSHPSA-N 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- FZCSTZYAHCUGEM-UHFFFAOYSA-N aspergillomarasmine B Natural products OC(=O)CNC(C(O)=O)CNC(C(O)=O)CC(O)=O FZCSTZYAHCUGEM-UHFFFAOYSA-N 0.000 description 1
- 229940120638 avastin Drugs 0.000 description 1
- 238000010170 biological method Methods 0.000 description 1
- 229940126587 biotherapeutics Drugs 0.000 description 1
- 238000010241 blood sampling Methods 0.000 description 1
- 230000007910 cell fusion Effects 0.000 description 1
- 229940044683 chemotherapy drug Drugs 0.000 description 1
- 238000009104 chemotherapy regimen Methods 0.000 description 1
- VDQQXEISLMTGAB-UHFFFAOYSA-N chloramine T Chemical compound [Na+].CC1=CC=C(S(=O)(=O)[N-]Cl)C=C1 VDQQXEISLMTGAB-UHFFFAOYSA-N 0.000 description 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 description 1
- 201000010989 colorectal carcinoma Diseases 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000011443 conventional therapy Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 210000000172 cytosol Anatomy 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 description 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 description 1
- 229940082789 erbitux Drugs 0.000 description 1
- 210000003527 eukaryotic cell Anatomy 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 108010078144 glutaminyl-glycine Proteins 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000002489 hematologic effect Effects 0.000 description 1
- 108060003552 hemocyanin Proteins 0.000 description 1
- 229940022353 herceptin Drugs 0.000 description 1
- 229960001001 ibritumomab tiuxetan Drugs 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 238000003364 immunohistochemistry Methods 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Inorganic materials [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 1
- 235000013980 iron oxide Nutrition 0.000 description 1
- VBMVTYDPPZVILR-UHFFFAOYSA-N iron(2+);oxygen(2-) Chemical class [O-2].[Fe+2] VBMVTYDPPZVILR-UHFFFAOYSA-N 0.000 description 1
- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 201000005296 lung carcinoma Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 208000010907 male breast carcinoma Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 201000000050 myeloid neoplasm Diseases 0.000 description 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 238000007500 overflow downdraw method Methods 0.000 description 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 1
- 230000003234 polygenic effect Effects 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 206010038038 rectal cancer Diseases 0.000 description 1
- 201000001275 rectum cancer Diseases 0.000 description 1
- 238000011946 reduction process Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 210000003660 reticulum Anatomy 0.000 description 1
- 229960004641 rituximab Drugs 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229960001479 tosylchloramide sodium Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 230000017105 transposition Effects 0.000 description 1
- 230000004565 tumor cell growth Effects 0.000 description 1
- 238000001132 ultrasonic dispersion Methods 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 210000003556 vascular endothelial cell Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Description
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2005101091314A CN1951962B (zh) | 2005-10-18 | 2005-10-18 | 用于制备抗肿瘤抗体的多肽及其应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2005101091314A CN1951962B (zh) | 2005-10-18 | 2005-10-18 | 用于制备抗肿瘤抗体的多肽及其应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1951962A CN1951962A (zh) | 2007-04-25 |
CN1951962B true CN1951962B (zh) | 2012-01-18 |
Family
ID=38058533
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2005101091314A Expired - Fee Related CN1951962B (zh) | 2005-10-18 | 2005-10-18 | 用于制备抗肿瘤抗体的多肽及其应用 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1951962B (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107573407A (zh) * | 2013-11-19 | 2018-01-12 | 中国科学院苏州纳米技术与纳米仿生研究所 | 多肽、其生产方法及用途 |
CN109705210B (zh) * | 2018-12-25 | 2020-12-29 | 深圳大学 | Oct4抗原表位肽、抗原偶联物及其制备方法和应用 |
-
2005
- 2005-10-18 CN CN2005101091314A patent/CN1951962B/zh not_active Expired - Fee Related
Non-Patent Citations (1)
Title |
---|
LILLEY, BN等.A membrane protein required for.NATURE.NATURE PUBLISHING GROUP,2004,429(24),834-840. * |
Also Published As
Publication number | Publication date |
---|---|
CN1951962A (zh) | 2007-04-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Pastuskovas et al. | Effects of anti-VEGF on pharmacokinetics, biodistribution, and tumor penetration of trastuzumab in a preclinical breast cancer model | |
CN104662044B (zh) | 用于治疗ror1癌症并抑制转移的抗体和疫苗 | |
KR102691790B1 (ko) | 항-pd-l1/vegf 이중 기능 항체 및 이의 용도 | |
CN104093743B (zh) | 特异于her3的结合分子及其用途 | |
CN100457781C (zh) | 抗癌抗体 | |
CN107135654A (zh) | 巨胞饮人类抗cd46抗体和靶向癌症疗法 | |
CN107840891A (zh) | 高亲和力的抗msln抗体及其应用 | |
CN103319599B (zh) | 一种抗人ErbB2抗体—美登木素偶联物及其应用 | |
CN101479296A (zh) | Trail受体结合剂和其用途 | |
CN102741292B (zh) | 在治疗头和颈鳞状细胞癌中使用的cd44单克隆抗体 | |
PT1718737E (pt) | Anticorpos que modificam doenças cancerosas | |
JP2008500964A5 (zh) | ||
CN101279093A (zh) | 癌症调节抗体 | |
WO1992007466A1 (en) | Synergistic therapy with combinations of anti-tumor antibodies and biologically active agents | |
CN108472359A (zh) | Trail受体结合剂及其用途 | |
CN1951962B (zh) | 用于制备抗肿瘤抗体的多肽及其应用 | |
CN104968684A (zh) | 新的抗体片段、组合物和其用途 | |
Crombet et al. | Phase I clinical evaluation of a neutralizing monoclonal antibody against epidermal growth factor receptor | |
KR20240041935A (ko) | 항-trop2 단일 도메인 항체 및 이의 응용 | |
CN1933851B (zh) | 使用抗-α5β1抗体抑制癌细胞增殖 | |
CN101497662B (zh) | 用于制备抗肿瘤抗体的tm4sf3蛋白及其应用 | |
Wagner et al. | Reduction of human melanoma tumor growth in severe combined immunodeficient mice by passive transfer of antibodies induced by a high molecular weight melanoma-associated antigen mimotope vaccine | |
CN101962405A (zh) | 一种人源乳腺癌抗原及其抗体 | |
WO2023031644A1 (en) | Anti-fibroblast activation protein (fap) single domain antibodies and uses thereof | |
CN102441166A (zh) | 一种单克隆抗体用于治疗头颈部肿瘤的用途 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: TUMOUR INST., CHINESE MEDICAL ACADEMY Free format text: FORMER OWNER: TUMAR INST OF TUMOOR HOSPITAL, CHINESE ACADEMY OF MEDICAL SCIENCES Effective date: 20090807 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20090807 Address after: Postal code 17, South Lane, Panjiayuan, Beijing, 100021: Chaoyang District Applicant after: Tumour Inst., China Medical Science Research Academy Address before: Postal code 17, South Lane, Panjiayuan, Beijing, 100021: Chaoyang District Applicant before: Tumour Research Inst. under Tumour Hospital of Chinese Academy of medical scienc |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120118 Termination date: 20141018 |
|
EXPY | Termination of patent right or utility model |