CN1942579B - 将氧化还原活性氨基酸位点特异地掺入蛋白质 - Google Patents

将氧化还原活性氨基酸位点特异地掺入蛋白质 Download PDF

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Publication number
CN1942579B
CN1942579B CN2004800301376A CN200480030137A CN1942579B CN 1942579 B CN1942579 B CN 1942579B CN 2004800301376 A CN2004800301376 A CN 2004800301376A CN 200480030137 A CN200480030137 A CN 200480030137A CN 1942579 B CN1942579 B CN 1942579B
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trna
quadrature
cell
amino acids
codon
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CN1942579A (zh
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L·阿方达
P·G·舒尔茨
张致文
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Scripps Research Institute
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

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  • Life Sciences & Earth Sciences (AREA)
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  • Biochemistry (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN2004800301376A 2003-10-14 2004-10-13 将氧化还原活性氨基酸位点特异地掺入蛋白质 Expired - Fee Related CN1942579B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US51153203P 2003-10-14 2003-10-14
US60/511,532 2003-10-14
PCT/US2004/034089 WO2005038002A2 (en) 2003-10-14 2004-10-13 Site-specific incorporation of redox active amino acids into proteins

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CN200910004743A Division CN101532046A (zh) 2003-10-14 2004-10-13 将氧化还原活性氨基酸位点特异地掺入蛋白质

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CN1942579A CN1942579A (zh) 2007-04-04
CN1942579B true CN1942579B (zh) 2013-06-26

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CN200910004743A Pending CN101532046A (zh) 2003-10-14 2004-10-13 将氧化还原活性氨基酸位点特异地掺入蛋白质

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US (5) US8008041B2 (cg-RX-API-DMAC7.html)
EP (1) EP1687401B1 (cg-RX-API-DMAC7.html)
JP (1) JP5657850B2 (cg-RX-API-DMAC7.html)
CN (2) CN1942579B (cg-RX-API-DMAC7.html)
AU (1) AU2004282577B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0415308A (cg-RX-API-DMAC7.html)
CA (1) CA2541166A1 (cg-RX-API-DMAC7.html)
DK (1) DK1687401T3 (cg-RX-API-DMAC7.html)
ES (1) ES2396712T3 (cg-RX-API-DMAC7.html)
IL (3) IL174947A (cg-RX-API-DMAC7.html)
MX (1) MXPA06004087A (cg-RX-API-DMAC7.html)
PL (1) PL1687401T3 (cg-RX-API-DMAC7.html)
PT (1) PT1687401E (cg-RX-API-DMAC7.html)
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IL158418A0 (en) * 2001-04-19 2004-05-12 Scripps Research Inst In vivo incorporation of unnatural amino acids
AU2003286436B2 (en) * 2002-10-16 2010-08-19 The Scripps Research Institute Glycoprotein synthesis
EP1613735B1 (en) 2003-04-17 2012-01-25 The Scripps Research Institute Expanding the eukaryotic genetic code
EP1636340A4 (en) 2003-06-18 2009-02-11 Scripps Research Inst COMPLEMENTS TO THE GENETIC CODE OF UNNATURATIVE REACTIVE AMINO ACIDS
PT1666604E (pt) * 2003-07-07 2008-05-19 Scripps Research Inst Composições de pares ortogonais de lisil-arnt e aminoacil-arnt-sintetase e suas utilizações
US7399619B2 (en) * 2004-05-25 2008-07-15 The Scripps Research Institute Site specific incorporation of heavy atom-containing unnatural amino acids into proteins for structure determination
DE102004031258A1 (de) * 2004-06-29 2006-02-09 Jennissen, Herbert P., Prof. Dr. Proteinhybride mit polyhydroxyaromatischen Aminosäure-Epitopen
US20060110784A1 (en) * 2004-09-22 2006-05-25 The Scripps Research Institute Site-specific labeling of proteins for NMR studies
EP2380982B1 (en) 2004-10-27 2014-07-16 The Scripps Research Institute Orthogonal translation components for the in vivo incorporation of unnatural amino acids
CN104789536A (zh) * 2005-10-12 2015-07-22 斯克利普斯研究院 噬菌体展示多肽的选择性翻译后修饰
WO2007092475A2 (en) * 2006-02-06 2007-08-16 Franklin And Marshall College Site-specific incorporation of fluorinated amino acids into proteins
JP5589186B2 (ja) * 2006-03-09 2014-09-17 ザ スクリプス リサーチ インスティテュート 真正細菌宿主細胞における直交翻訳成分の発現システム
WO2007109035A2 (en) 2006-03-16 2007-09-27 The Scripps Research Institute Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine
EP2018429A4 (en) * 2006-05-23 2010-07-14 Scrips Res Inst GENETICALLY ENCODED FLUORESCENT CUMARIN AMINO ACIDS
EP2052083B1 (en) * 2006-09-21 2014-01-08 The Scripps Research Institute Genetically programmed expression of selectively sulfated proteins in eubacteria
CN101535338A (zh) 2006-10-18 2009-09-16 斯克利普斯研究院 在哺乳动物细胞中将非天然氨基酸遗传掺入蛋白质
WO2008137452A1 (en) * 2007-05-04 2008-11-13 Kenergy Royalty Company, Llc Implantable high efficiency digital stimulation device
CA2703736A1 (en) * 2007-10-25 2009-04-30 The Scripps Research Institute Genetic incorporation of 3-aminotyrosine into reductases
EP2220218A4 (en) * 2007-11-02 2010-12-08 Scripps Research Inst GENETICALLY ENCODED BORONATE AMINO ACID
EP2217702A4 (en) 2007-11-02 2012-05-16 Scripps Research Inst DIRECTED EVOLUTION USING PROTEINS WITH NON-NATURAL AMINO ACIDS
EP2231856A4 (en) * 2007-12-11 2011-05-18 Scripps Research Inst IN VIVO EXPRESSION OF NON-NATURAL AMINO ACIDS IN THE METHYLOTROPHIC YEAST PICHIA PASTORIS
BRPI0906388A2 (pt) * 2008-02-08 2015-07-07 Scripps Research Inst Quebra de tolerância imunológica com um aminoácido não natural geneticamente codificado
CA2746213A1 (en) * 2008-12-09 2010-07-08 Wilson-Cook Medical Inc. Apparatus and methods for controlled release of tacking devices
US20090197339A1 (en) * 2008-12-10 2009-08-06 The Scripps Research Institute In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris
WO2010068278A2 (en) 2008-12-10 2010-06-17 The Scripps Research Institute Production of carrier-peptide conjugates using chemically reactive unnatural amino acids
EP2394323B1 (en) * 2009-02-04 2017-05-24 Ben-gurion University Of The Negev Research And Development Authority Systems and methods for bio-electricity production
EP2976362B1 (en) 2013-03-19 2019-10-23 Beijing Shenogen Pharma Group Ltd. Antibodies and methods for treating estrogen receptor-associated diseases
US20150331624A1 (en) * 2014-05-19 2015-11-19 Kabushiki Kaisha Toshiba Host-controlled flash translation layer snapshot
KR101956042B1 (ko) * 2017-07-13 2019-03-08 서강대학교산학협력단 표적 단백질 내 l-디하이드록시페닐알라닌의 도입 방법
CN114008176A (zh) 2019-06-17 2022-02-01 默克专利股份有限公司 基于液晶的光阀

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1231697A (zh) * 1996-08-29 1999-10-13 麻省理工学院 体内蛋白质合成的方法

Family Cites Families (9)

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IL158418A0 (en) * 2001-04-19 2004-05-12 Scripps Research Inst In vivo incorporation of unnatural amino acids
ATE429500T1 (de) 2002-10-16 2009-05-15 Scripps Research Inst Stellenspezifischer einbau von ketoaminosäuren in proteine
AU2003286436B2 (en) 2002-10-16 2010-08-19 The Scripps Research Institute Glycoprotein synthesis
WO2004058946A2 (en) 2002-12-22 2004-07-15 The Scripps Research Institute Protein arrays
EP1613735B1 (en) 2003-04-17 2012-01-25 The Scripps Research Institute Expanding the eukaryotic genetic code
EP1636340A4 (en) 2003-06-18 2009-02-11 Scripps Research Inst COMPLEMENTS TO THE GENETIC CODE OF UNNATURATIVE REACTIVE AMINO ACIDS
EP1704242A4 (en) 2003-07-07 2008-06-18 Scripps Research Inst COMPOSITIONS WITH PAIRS OF ORTHOGONAL LEUCYL-TRNA AND AMINOACYL-TRNA-SYNTHETASE AND USES THEREOF
PT1666604E (pt) 2003-07-07 2008-05-19 Scripps Research Inst Composições de pares ortogonais de lisil-arnt e aminoacil-arnt-sintetase e suas utilizações
EP1658366A4 (en) 2003-07-07 2006-08-09 Scripps Research Inst COMPOSITIONS OF ORTHOGONAL GLUTAMYL-TRNA AND AMINOACYL-TRNA-SYNTHETASEPAARES AND THEIR USES

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
CN1231697A (zh) * 1996-08-29 1999-10-13 麻省理工学院 体内蛋白质合成的方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Q57834(登录号).EBI,1997, *

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BRPI0415308A (pt) 2006-12-05
EP1687401A2 (en) 2006-08-09
AU2004282577A1 (en) 2005-04-28
IL201705A0 (en) 2011-08-01
US8008041B2 (en) 2011-08-30
US20120100570A1 (en) 2012-04-26
US20090298124A1 (en) 2009-12-03
IL206889A0 (en) 2010-12-30
PL1687401T3 (pl) 2013-04-30
JP2007508034A (ja) 2007-04-05
DK1687401T3 (da) 2013-02-04
CN1942579A (zh) 2007-04-04
US7494796B2 (en) 2009-02-24
US9783798B2 (en) 2017-10-10
EP1687401A4 (en) 2007-08-01
US7811801B2 (en) 2010-10-12
IL174947A (en) 2011-11-30
US20110008782A1 (en) 2011-01-13
EP1687401B1 (en) 2012-11-21
PT1687401E (pt) 2013-02-26
US20050227318A1 (en) 2005-10-13
US20070009990A1 (en) 2007-01-11
IL174947A0 (en) 2006-08-20
CA2541166A1 (en) 2005-04-28
ES2396712T3 (es) 2013-02-25
JP5657850B2 (ja) 2015-01-21
MXPA06004087A (es) 2006-06-27
CN101532046A (zh) 2009-09-16
US8114654B2 (en) 2012-02-14
WO2005038002A3 (en) 2006-11-23
AU2004282577B2 (en) 2009-10-29
WO2005038002A2 (en) 2005-04-28

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