AU2004282577B2 - Site-specific incorporation of redox active amino acids into proteins - Google Patents
Site-specific incorporation of redox active amino acids into proteins Download PDFInfo
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- AU2004282577B2 AU2004282577B2 AU2004282577A AU2004282577A AU2004282577B2 AU 2004282577 B2 AU2004282577 B2 AU 2004282577B2 AU 2004282577 A AU2004282577 A AU 2004282577A AU 2004282577 A AU2004282577 A AU 2004282577A AU 2004282577 B2 AU2004282577 B2 AU 2004282577B2
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- trna
- amino acid
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- redox active
- protein
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- NZVYCXVTEHPMHE-ZSUJOUNUSA-N thymalfasin Chemical compound CC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O NZVYCXVTEHPMHE-ZSUJOUNUSA-N 0.000 description 1
- 229960004231 thymalfasin Drugs 0.000 description 1
- 229940113082 thymine Drugs 0.000 description 1
- 229960000187 tissue plasminogen activator Drugs 0.000 description 1
- 238000006257 total synthesis reaction Methods 0.000 description 1
- 238000002723 toxicity assay Methods 0.000 description 1
- 230000005026 transcription initiation Effects 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
- 230000014621 translational initiation Effects 0.000 description 1
- 239000001226 triphosphate Substances 0.000 description 1
- 235000011178 triphosphate Nutrition 0.000 description 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 1
- 239000002753 trypsin inhibitor Substances 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 description 1
- 229960005356 urokinase Drugs 0.000 description 1
- 208000007089 vaccinia Diseases 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
- JPZXHKDZASGCLU-LBPRGKRZSA-N β-(2-naphthyl)-alanine Chemical compound C1=CC=CC2=CC(C[C@H](N)C(O)=O)=CC=C21 JPZXHKDZASGCLU-LBPRGKRZSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
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| US51153203P | 2003-10-14 | 2003-10-14 | |
| US60/511,532 | 2003-10-14 | ||
| PCT/US2004/034089 WO2005038002A2 (en) | 2003-10-14 | 2004-10-13 | Site-specific incorporation of redox active amino acids into proteins |
Publications (2)
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| AU2004282577A1 AU2004282577A1 (en) | 2005-04-28 |
| AU2004282577B2 true AU2004282577B2 (en) | 2009-10-29 |
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| AU2004282577A Ceased AU2004282577B2 (en) | 2003-10-14 | 2004-10-13 | Site-specific incorporation of redox active amino acids into proteins |
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| EP (1) | EP1687401B1 (cg-RX-API-DMAC7.html) |
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| PT (1) | PT1687401E (cg-RX-API-DMAC7.html) |
| WO (1) | WO2005038002A2 (cg-RX-API-DMAC7.html) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| IL158418A0 (en) * | 2001-04-19 | 2004-05-12 | Scripps Research Inst | In vivo incorporation of unnatural amino acids |
| AU2003286436B2 (en) * | 2002-10-16 | 2010-08-19 | The Scripps Research Institute | Glycoprotein synthesis |
| EP1613735B1 (en) | 2003-04-17 | 2012-01-25 | The Scripps Research Institute | Expanding the eukaryotic genetic code |
| EP1636340A4 (en) | 2003-06-18 | 2009-02-11 | Scripps Research Inst | COMPLEMENTS TO THE GENETIC CODE OF UNNATURATIVE REACTIVE AMINO ACIDS |
| PT1666604E (pt) * | 2003-07-07 | 2008-05-19 | Scripps Research Inst | Composições de pares ortogonais de lisil-arnt e aminoacil-arnt-sintetase e suas utilizações |
| US7399619B2 (en) * | 2004-05-25 | 2008-07-15 | The Scripps Research Institute | Site specific incorporation of heavy atom-containing unnatural amino acids into proteins for structure determination |
| DE102004031258A1 (de) * | 2004-06-29 | 2006-02-09 | Jennissen, Herbert P., Prof. Dr. | Proteinhybride mit polyhydroxyaromatischen Aminosäure-Epitopen |
| US20060110784A1 (en) * | 2004-09-22 | 2006-05-25 | The Scripps Research Institute | Site-specific labeling of proteins for NMR studies |
| EP2380982B1 (en) | 2004-10-27 | 2014-07-16 | The Scripps Research Institute | Orthogonal translation components for the in vivo incorporation of unnatural amino acids |
| CN104789536A (zh) * | 2005-10-12 | 2015-07-22 | 斯克利普斯研究院 | 噬菌体展示多肽的选择性翻译后修饰 |
| WO2007092475A2 (en) * | 2006-02-06 | 2007-08-16 | Franklin And Marshall College | Site-specific incorporation of fluorinated amino acids into proteins |
| JP5589186B2 (ja) * | 2006-03-09 | 2014-09-17 | ザ スクリプス リサーチ インスティテュート | 真正細菌宿主細胞における直交翻訳成分の発現システム |
| WO2007109035A2 (en) | 2006-03-16 | 2007-09-27 | The Scripps Research Institute | Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine |
| EP2018429A4 (en) * | 2006-05-23 | 2010-07-14 | Scrips Res Inst | GENETICALLY ENCODED FLUORESCENT CUMARIN AMINO ACIDS |
| EP2052083B1 (en) * | 2006-09-21 | 2014-01-08 | The Scripps Research Institute | Genetically programmed expression of selectively sulfated proteins in eubacteria |
| CN101535338A (zh) | 2006-10-18 | 2009-09-16 | 斯克利普斯研究院 | 在哺乳动物细胞中将非天然氨基酸遗传掺入蛋白质 |
| WO2008137452A1 (en) * | 2007-05-04 | 2008-11-13 | Kenergy Royalty Company, Llc | Implantable high efficiency digital stimulation device |
| CA2703736A1 (en) * | 2007-10-25 | 2009-04-30 | The Scripps Research Institute | Genetic incorporation of 3-aminotyrosine into reductases |
| EP2220218A4 (en) * | 2007-11-02 | 2010-12-08 | Scripps Research Inst | GENETICALLY ENCODED BORONATE AMINO ACID |
| EP2217702A4 (en) | 2007-11-02 | 2012-05-16 | Scripps Research Inst | DIRECTED EVOLUTION USING PROTEINS WITH NON-NATURAL AMINO ACIDS |
| EP2231856A4 (en) * | 2007-12-11 | 2011-05-18 | Scripps Research Inst | IN VIVO EXPRESSION OF NON-NATURAL AMINO ACIDS IN THE METHYLOTROPHIC YEAST PICHIA PASTORIS |
| BRPI0906388A2 (pt) * | 2008-02-08 | 2015-07-07 | Scripps Research Inst | Quebra de tolerância imunológica com um aminoácido não natural geneticamente codificado |
| CA2746213A1 (en) * | 2008-12-09 | 2010-07-08 | Wilson-Cook Medical Inc. | Apparatus and methods for controlled release of tacking devices |
| US20090197339A1 (en) * | 2008-12-10 | 2009-08-06 | The Scripps Research Institute | In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris |
| WO2010068278A2 (en) | 2008-12-10 | 2010-06-17 | The Scripps Research Institute | Production of carrier-peptide conjugates using chemically reactive unnatural amino acids |
| EP2394323B1 (en) * | 2009-02-04 | 2017-05-24 | Ben-gurion University Of The Negev Research And Development Authority | Systems and methods for bio-electricity production |
| EP2976362B1 (en) | 2013-03-19 | 2019-10-23 | Beijing Shenogen Pharma Group Ltd. | Antibodies and methods for treating estrogen receptor-associated diseases |
| US20150331624A1 (en) * | 2014-05-19 | 2015-11-19 | Kabushiki Kaisha Toshiba | Host-controlled flash translation layer snapshot |
| KR101956042B1 (ko) * | 2017-07-13 | 2019-03-08 | 서강대학교산학협력단 | 표적 단백질 내 l-디하이드록시페닐알라닌의 도입 방법 |
| CN114008176A (zh) | 2019-06-17 | 2022-02-01 | 默克专利股份有限公司 | 基于液晶的光阀 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2002086075A2 (en) * | 2001-04-19 | 2002-10-31 | The Scripps Research Institute | Methods and composition for the production of orthoganal trna-aminoacyltrna synthetase pairs |
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| US5879905A (en) * | 1996-08-29 | 1999-03-09 | Massachusetts Institute Of Technology | In vivo method of initiating protein synthesis with an amino acid other than methionine |
| ATE429500T1 (de) | 2002-10-16 | 2009-05-15 | Scripps Research Inst | Stellenspezifischer einbau von ketoaminosäuren in proteine |
| AU2003286436B2 (en) | 2002-10-16 | 2010-08-19 | The Scripps Research Institute | Glycoprotein synthesis |
| WO2004058946A2 (en) | 2002-12-22 | 2004-07-15 | The Scripps Research Institute | Protein arrays |
| EP1613735B1 (en) | 2003-04-17 | 2012-01-25 | The Scripps Research Institute | Expanding the eukaryotic genetic code |
| EP1636340A4 (en) | 2003-06-18 | 2009-02-11 | Scripps Research Inst | COMPLEMENTS TO THE GENETIC CODE OF UNNATURATIVE REACTIVE AMINO ACIDS |
| EP1704242A4 (en) | 2003-07-07 | 2008-06-18 | Scripps Research Inst | COMPOSITIONS WITH PAIRS OF ORTHOGONAL LEUCYL-TRNA AND AMINOACYL-TRNA-SYNTHETASE AND USES THEREOF |
| PT1666604E (pt) | 2003-07-07 | 2008-05-19 | Scripps Research Inst | Composições de pares ortogonais de lisil-arnt e aminoacil-arnt-sintetase e suas utilizações |
| EP1658366A4 (en) | 2003-07-07 | 2006-08-09 | Scripps Research Inst | COMPOSITIONS OF ORTHOGONAL GLUTAMYL-TRNA AND AMINOACYL-TRNA-SYNTHETASEPAARES AND THEIR USES |
-
2004
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- 2004-10-13 PL PL04795276T patent/PL1687401T3/pl unknown
- 2004-10-13 US US10/575,991 patent/US8008041B2/en not_active Expired - Lifetime
- 2004-10-13 DK DK04795276.7T patent/DK1687401T3/da active
- 2004-10-13 ES ES04795276T patent/ES2396712T3/es not_active Expired - Lifetime
- 2004-10-13 US US10/965,218 patent/US7494796B2/en not_active Expired - Lifetime
- 2004-10-13 WO PCT/US2004/034089 patent/WO2005038002A2/en not_active Ceased
- 2004-10-13 JP JP2006535350A patent/JP5657850B2/ja not_active Expired - Fee Related
- 2004-10-13 BR BRPI0415308-1A patent/BRPI0415308A/pt not_active IP Right Cessation
- 2004-10-13 AU AU2004282577A patent/AU2004282577B2/en not_active Ceased
- 2004-10-13 EP EP04795276A patent/EP1687401B1/en not_active Expired - Lifetime
- 2004-10-13 CN CN200910004743A patent/CN101532046A/zh active Pending
- 2004-10-13 PT PT47952767T patent/PT1687401E/pt unknown
- 2004-10-13 CA CA002541166A patent/CA2541166A1/en not_active Abandoned
- 2004-10-13 MX MXPA06004087A patent/MXPA06004087A/es active IP Right Grant
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2006
- 2006-04-11 IL IL174947A patent/IL174947A/en not_active IP Right Cessation
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2008
- 2008-12-17 US US12/317,034 patent/US7811801B2/en not_active Expired - Lifetime
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2009
- 2009-10-22 IL IL201705A patent/IL201705A0/en unknown
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2010
- 2010-07-08 IL IL206889A patent/IL206889A0/en unknown
- 2010-08-20 US US12/806,751 patent/US8114654B2/en not_active Expired - Lifetime
-
2012
- 2012-01-05 US US13/344,436 patent/US9783798B2/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002086075A2 (en) * | 2001-04-19 | 2002-10-31 | The Scripps Research Institute | Methods and composition for the production of orthoganal trna-aminoacyltrna synthetase pairs |
| US20090068717A1 (en) * | 2001-04-19 | 2009-03-12 | The Scripps Research Institute | In vivo incorporation of unnatural amino acids |
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0415308A (pt) | 2006-12-05 |
| CN1942579B (zh) | 2013-06-26 |
| EP1687401A2 (en) | 2006-08-09 |
| AU2004282577A1 (en) | 2005-04-28 |
| IL201705A0 (en) | 2011-08-01 |
| US8008041B2 (en) | 2011-08-30 |
| US20120100570A1 (en) | 2012-04-26 |
| US20090298124A1 (en) | 2009-12-03 |
| IL206889A0 (en) | 2010-12-30 |
| PL1687401T3 (pl) | 2013-04-30 |
| JP2007508034A (ja) | 2007-04-05 |
| DK1687401T3 (da) | 2013-02-04 |
| CN1942579A (zh) | 2007-04-04 |
| US7494796B2 (en) | 2009-02-24 |
| US9783798B2 (en) | 2017-10-10 |
| EP1687401A4 (en) | 2007-08-01 |
| US7811801B2 (en) | 2010-10-12 |
| IL174947A (en) | 2011-11-30 |
| US20110008782A1 (en) | 2011-01-13 |
| EP1687401B1 (en) | 2012-11-21 |
| PT1687401E (pt) | 2013-02-26 |
| US20050227318A1 (en) | 2005-10-13 |
| US20070009990A1 (en) | 2007-01-11 |
| IL174947A0 (en) | 2006-08-20 |
| CA2541166A1 (en) | 2005-04-28 |
| ES2396712T3 (es) | 2013-02-25 |
| JP5657850B2 (ja) | 2015-01-21 |
| MXPA06004087A (es) | 2006-06-27 |
| CN101532046A (zh) | 2009-09-16 |
| US8114654B2 (en) | 2012-02-14 |
| WO2005038002A3 (en) | 2006-11-23 |
| WO2005038002A2 (en) | 2005-04-28 |
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