CN1927313A - 治疗咽炎的药物组合物 - Google Patents
治疗咽炎的药物组合物 Download PDFInfo
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- CN1927313A CN1927313A CN 200510011004 CN200510011004A CN1927313A CN 1927313 A CN1927313 A CN 1927313A CN 200510011004 CN200510011004 CN 200510011004 CN 200510011004 A CN200510011004 A CN 200510011004A CN 1927313 A CN1927313 A CN 1927313A
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Abstract
Description
菌种 | 菌号 | 最低抑菌浓度MIC(片/ml) |
金黄色葡萄球菌大肠杆菌绿脓杆菌表皮葡萄球菌乙型溶血性链球菌白色念球菌肺炎链球菌 | CMCC(B)26003CMCC(B)44102CMCC(B)10104CMCC(B)26096CMCC(B)32172CMCC(B)98001CMCC(B)31002 | 0.030.060.110.060.220.110.03 |
菌种 | 菌株数 | MIC范围(片/ml) |
金黄色葡萄球菌大肠埃希氏菌绿脓杆菌表皮葡萄球菌甲型溶血性链球菌白色念球菌 | 302020303540 | 0.01~0.110.01~0.110.01~0.110.03~0.220.01~0.220.01~0.22 |
组别 | 动物数(只) | 剂量(片/kg) | 死亡数(只) | 死亡率(%) |
对照组交沙霉素片本发明含片 | 2020202020 | 水10.06.03.01.5 | 202**141518 | 10010707590 |
组别 | 动物数(只) | 剂量(片/kg) | 耳肿胀度(mg) | 抑制率(%) |
对照组地塞米松片本发明含片 | 1010101010 | 水2.06.03.01.5 | 24.0±2.2816.0±3.70**19.9±3.26**20.8±3.07*21.5±3.59 | -33.317.113.310.4 |
组别 | 动物数(只) | 剂量(片/kg) | 致炎后不同时间肿胀度(mm) | ||||||
0.5h | 1h | 2h | 3h | 4h | 5h | 6h | |||
对照组地塞米松片本发明含片 | 1010101010 | 水2.03.01.50.8 | 4.95±0.780.56±0.46**3.57±0.93**3.84±0.82**3.42±1.14** | 4.79±1.050.47±0.23**3.36±1.05**4.44±0.914.10±0.89 | 4.62±0.490.35±0.27**3.11±0.64**3.83±0.70**4.23±0.45 | 3.54±0.670.26±0.26**2.59±0.46**3.80±0.783.75±0.41 | 2.60±0.610.19±0.23**1.69±0.69**2.93±1.392.97±0.38 | 2.37±0.640.05±0.33**1.13±0.72**2.53±1.042.48±0.32 | 1.32±0.71-0.04±0.33**0.65±0.57*1.84±1.211.40±0.31 |
组别 | 动物数(只) | 剂量(片/kg) | 渗出液(ml) | WBC(个×109/L) |
对照组地塞米松片本发明含片 | 1010101010 | 水2.03.01.50.8 | 2.14±0.160.30±0.23**1.82±0.29**2.09±0.511.89±0.64 | 75.4±25.132.9±11.0**43.3±3.34**48.1±10.3**47.3±14.2** |
组别 | 动物数(只) | 剂量(片/kg) | 肉芽肿干重(mg) |
对照组地塞米松片本发明含片 | 1010101010 | 水2.03.01.50.8 | 34.5±5.7411.2±1.98**31.1±4.5831.1±3.7835.4±4.10 |
组别 | 动物数(只) | 剂量(片/kg) | 基础体温(℃) | 温度升高度数(℃) | |||||
0.5h | 1.0h | 1.5h | 2.0h | 2.5h | 3.0h | ||||
对照组对乙酰氨基酚片本发明含片 | 1010101010 | 水0.53.01.50.8 | 38.3±0.2738.2±0.4238.4±0.36**38.4±0.3938.4±0.47 | 0.90±0.220.46±0.27**0.57±0.19**0.69±0.270.70±0.31 | 0.73±0.230.15±0.23**0.35±0.38*0.38±0.45*0.53±0.28 | 0.66±0.28-0.13±0.28**0.25±0.37*0.14±0.36**0.35±0.26* | 0.56±0.35-0.28±0.28**0.05±0.34**0.06±0.46**0.11±0.29** | 0.32±0.26-0.20±0.30**-0.22±0.45**0.10±0.460.00±0.42 | 0.14±0.23-0.15±0.29**-0.19±0.31*-0.13±0.51-0.06±0.30 |
组别 | 动物数(只) | 剂量(片/kg) | 扭体次数(次) | 抑制率(%) |
对照组罗通定片本发明含片 | 1010101010 | 水0.56.03.01.5 | 32.8±11.28.30±4.94**9.70±4.62**10.1±5.74**11.6±6.31** | -74.770.469.264.6 |
组别 | 动物数(只) | 剂量(片/kg) | 药前痛阈(s) | 药后痛阈(s) | |||
0.5h | 1.0h | 1.5h | 2.0h | ||||
对照组罗通定片本发明含片 | 1010101010 | 水0.53.01.50.8 | 15.1±3.2115.5±4.2015.8±3.6115.4±4.8815.5±5.10 | 15.3±4.3727.1±13.0*△25.6±8.36**△△25.8±12.9*△26.9±13.9*△ | 14.7±4.8830.1±17.4*△28.2±11.9**△△27.7±12.7**△△28.2±15.4*△ | 15.0±5.4230.0±17.0*△30.8±14.0**△△31.6±12.7*△21.9±7.12*△ | 15.2±5.5129.4±16.0*△27.0±16.4*△26.2±13.8*△18.3±5.14 |
组别 | 动物数 | 剂量(片/kg) | OD值 | K | 肝脾合重(mg/g) | |
2s | 7s | |||||
空白对照组左旋咪唑片本发明含片 | 水1.06.03.01.5 | 0.25±0.040.29±0.050.24±0.090.26±0.050.29±0.05 | 0.16±0.030.16±0.040.12±0.040.12±0.040.16±0.04 | 0.040±0.0040.051±0.013*0.063±0.019**0.067±0.025**0.050±0.012* | 54.6±18.067.0±10.657.6±4.9659.3±3.0655.4±5.18 |
组别 | 动物数(只) | 剂量(片/kg) | 吞噬百分率(%) | 吞噬指数 |
对照组左旋咪唑片本发明含片 | 1010101010 | 水1.06.03.01.5 | 20.6±3.6437.2±6.01**0.6±4.74**29.2±4.36**27.0±4.13* | 0.72±0.111.04±0.17**1.02±0.09**0.94±0.09**0.85±0.11* |
组别 | 动物数(只) | 剂量(片/kg) | 平均反应值 | |||
24h | 48h | 72h | 7天 | |||
对照组给药组 | 55 | 1ml1.0 | 00 | 00 | 00 | 00 |
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CNB2005100110040A CN100469378C (zh) | 2005-09-07 | 2005-09-07 | 治疗咽炎的药物组合物 |
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CNB2005100110040A CN100469378C (zh) | 2005-09-07 | 2005-09-07 | 治疗咽炎的药物组合物 |
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CN100469378C CN100469378C (zh) | 2009-03-18 |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101856424B (zh) * | 2009-09-03 | 2011-10-05 | 张钦 | 治疗慢性咽炎病的中药 |
CN104042701A (zh) * | 2014-05-11 | 2014-09-17 | 上海浦东高星生物技术研究所 | 清咽含片 |
-
2005
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101856424B (zh) * | 2009-09-03 | 2011-10-05 | 张钦 | 治疗慢性咽炎病的中药 |
CN104042701A (zh) * | 2014-05-11 | 2014-09-17 | 上海浦东高星生物技术研究所 | 清咽含片 |
CN104042701B (zh) * | 2014-05-11 | 2016-02-03 | 黄涵 | 清咽含片 |
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Assignee: Yunan Xitao Green Pharmaceutical Co., Ltd. Assignor: Liang Zhenhui Contract fulfillment period: 2009.8.15 to 2011.8.14 Contract record no.: 2009530000010 Denomination of invention: Medicinal composition for treating pharyngitis Granted publication date: 20090318 License type: Exclusive license Record date: 2009.8.26 Assignee: Yunan Xitao Green Pharmaceutical Co., Ltd. Assignor: Liang Zhenhui Contract fulfillment period: 2009.8.28 to 2014.8.14 Contract record no.: 2009530000029 Denomination of invention: Medicinal composition for treating pharyngitis Granted publication date: 20090318 License type: Exclusive license Record date: 2009.10.9 |
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