CN1917909A - 设计的脊柱植入物复合材料降解 - Google Patents

设计的脊柱植入物复合材料降解 Download PDF

Info

Publication number
CN1917909A
CN1917909A CNA2004800408585A CN200480040858A CN1917909A CN 1917909 A CN1917909 A CN 1917909A CN A2004800408585 A CNA2004800408585 A CN A2004800408585A CN 200480040858 A CN200480040858 A CN 200480040858A CN 1917909 A CN1917909 A CN 1917909A
Authority
CN
China
Prior art keywords
composite
fibril
group
fine rope
flexible
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2004800408585A
Other languages
English (en)
Inventor
F·J·莫兹四世
M·C·舍曼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SDGI Holdings Inc
Warsaw Orthopedic Inc
Original Assignee
Warsaw Orthopedic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warsaw Orthopedic Inc filed Critical Warsaw Orthopedic Inc
Publication of CN1917909A publication Critical patent/CN1917909A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/80—Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
    • A61B17/8085—Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates with pliable or malleable elements or having a mesh-like structure, e.g. small strips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
    • A61B17/7059—Cortical plates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2/30965—Reinforcing the prosthesis by embedding particles or fibres during moulding or dipping
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L31/125—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L31/129—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix containing macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
    • A61B17/7001—Screws or hooks combined with longitudinal elements which do not contact vertebrae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/84—Fasteners therefor or fasteners being internal fixation devices
    • A61B17/86—Pins or screws or threaded wires; nuts therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00004—(bio)absorbable, (bio)resorbable or resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2825—Femur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/30004—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/30004—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
    • A61F2002/30009—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis differing in fibre orientations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/30004—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
    • A61F2002/30014—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis differing in elasticity, stiffness or compressibility
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/30004—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
    • A61F2002/30032—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis differing in absorbability or resorbability, i.e. in absorption or resorption time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • A61F2002/30064—Coating or prosthesis-covering structure made of biodegradable material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30092—Properties of materials and coating materials using shape memory or superelastic materials, e.g. nitinol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/3011—Cross-sections or two-dimensional shapes
    • A61F2002/30138—Convex polygonal shapes
    • A61F2002/30153—Convex polygonal shapes rectangular
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/3011—Cross-sections or two-dimensional shapes
    • A61F2002/30138—Convex polygonal shapes
    • A61F2002/30154—Convex polygonal shapes square
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A61F2002/30224—Three-dimensional shapes cylindrical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A61F2002/30242—Three-dimensional shapes spherical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A61F2002/30261—Three-dimensional shapes parallelepipedal
    • A61F2002/30263—Three-dimensional shapes parallelepipedal cubical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A61F2002/30289—Three-dimensional shapes helically-coiled
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30317—The prosthesis having different structural features at different locations within the same prosthesis
    • A61F2002/30327—The prosthesis having different structural features at different locations within the same prosthesis differing in diameter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2002/30448—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30667—Features concerning an interaction with the environment or a particular use of the prosthesis
    • A61F2002/30677—Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2/30907—Nets or sleeves applied to surface of prostheses or in cement
    • A61F2002/30909—Nets
    • A61F2002/30914—Details of the mesh structure, e.g. disposition of the woven warp and weft wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
    • A61F2002/30957—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using a positive or a negative model, e.g. moulds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2002/4495—Joints for the spine, e.g. vertebrae, spinal discs having a fabric structure, e.g. made from wires or fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0014—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/005—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0017—Angular shapes
    • A61F2230/0019—Angular shapes rectangular
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0017—Angular shapes
    • A61F2230/0021—Angular shapes square
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0069—Three-dimensional shapes cylindrical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0071—Three-dimensional shapes spherical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0082—Three-dimensional shapes parallelepipedal
    • A61F2230/0084—Three-dimensional shapes parallelepipedal cubical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0091—Three-dimensional shapes helically-coiled or spirally-coiled, i.e. having a 2-D spiral cross-section
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0018—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in elasticity, stiffness or compressibility
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0028—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in fibre orientations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0029—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in bending or flexure capacity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/003—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in adsorbability or resorbability, i.e. in adsorption or resorption time
    • A61F2250/0031—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in adsorbability or resorbability, i.e. in adsorption or resorption time made from both resorbable and non-resorbable prosthetic parts, e.g. adjacent parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0039—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in diameter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00017—Iron- or Fe-based alloys, e.g. stainless steel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00023—Titanium or titanium-based alloys, e.g. Ti-Ni alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00029—Cobalt-based alloys, e.g. Co-Cr alloys or Vitallium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00035—Other metals or alloys
    • A61F2310/00095—Niobium or Nb-based alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00035—Other metals or alloys
    • A61F2310/00125—Hafnium or Hf-based alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00035—Other metals or alloys
    • A61F2310/00131—Tantalum or Ta-based alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00035—Other metals or alloys
    • A61F2310/00137—Tungsten or W-based alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T442/00—Fabric [woven, knitted, or nonwoven textile or cloth, etc.]
    • Y10T442/10—Scrim [e.g., open net or mesh, gauze, loose or open weave or knit, etc.]
    • Y10T442/102—Woven scrim
    • Y10T442/109—Metal or metal-coated fiber-containing scrim
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T442/00—Fabric [woven, knitted, or nonwoven textile or cloth, etc.]
    • Y10T442/10—Scrim [e.g., open net or mesh, gauze, loose or open weave or knit, etc.]
    • Y10T442/102—Woven scrim
    • Y10T442/164—Including a preformed film, foil, or sheet
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T442/00—Fabric [woven, knitted, or nonwoven textile or cloth, etc.]
    • Y10T442/10—Scrim [e.g., open net or mesh, gauze, loose or open weave or knit, etc.]
    • Y10T442/102—Woven scrim
    • Y10T442/172—Coated or impregnated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T442/00—Fabric [woven, knitted, or nonwoven textile or cloth, etc.]
    • Y10T442/10—Scrim [e.g., open net or mesh, gauze, loose or open weave or knit, etc.]
    • Y10T442/102—Woven scrim
    • Y10T442/172—Coated or impregnated
    • Y10T442/178—Synthetic polymeric fiber
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T442/00—Fabric [woven, knitted, or nonwoven textile or cloth, etc.]
    • Y10T442/20—Coated or impregnated woven, knit, or nonwoven fabric which is not [a] associated with another preformed layer or fiber layer or, [b] with respect to woven and knit, characterized, respectively, by a particular or differential weave or knit, wherein the coating or impregnation is neither a foamed material nor a free metal or alloy layer
    • Y10T442/2361—Coating or impregnation improves stiffness of the fabric other than specified as a size
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T442/00—Fabric [woven, knitted, or nonwoven textile or cloth, etc.]
    • Y10T442/30—Woven fabric [i.e., woven strand or strip material]
    • Y10T442/3382—Including a free metal or alloy constituent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T442/00—Fabric [woven, knitted, or nonwoven textile or cloth, etc.]
    • Y10T442/30—Woven fabric [i.e., woven strand or strip material]
    • Y10T442/3472—Woven fabric including an additional woven fabric layer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T442/00—Fabric [woven, knitted, or nonwoven textile or cloth, etc.]
    • Y10T442/30—Woven fabric [i.e., woven strand or strip material]
    • Y10T442/3854—Woven fabric with a preformed polymeric film or sheet
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T442/00—Fabric [woven, knitted, or nonwoven textile or cloth, etc.]
    • Y10T442/30—Woven fabric [i.e., woven strand or strip material]
    • Y10T442/3976—Including strand which is stated to have specific attributes [e.g., heat or fire resistance, chemical or solvent resistance, high absorption for aqueous composition, water solubility, heat shrinkability, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Materials Engineering (AREA)
  • Composite Materials (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Manufacturing & Machinery (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

本发明包括用于构建矫形装置的复合材料和这些复合材料的使用方法。复合材料由至少一根非生物降解纤丝或纤索和可生物降解基质构成。在其它形式中，复合材料包含至少两个由可生物降解材料形成的组件，该组件可为基质或纤丝或基质与纤丝的组合。这两个组件的降解速率不必相同。复合材料用于构建改变体内物理性质的矫形装置，例如骨板、骨杆、脊柱杆、层合片。

Description

设计的脊柱植入物复合材料降解
发明领域
本发明一般涉及用于构建促进骨融合的矫形装置的复合材料，矫形装置，以及使用这些材料和装置治疗矫形外科缺损的方法。
哺乳动物骨骼系统，包括长骨、短骨、扁骨和不规则骨，易受疾病、损伤和先天性缺陷的侵袭，所有这些都可导致骨缺损。疾病、损伤和变形对患者健康造成严重损害，导致急性疼痛或慢性消耗疼痛。
缺损骨组织的一般治疗包括将折断的骨区段或部分连接或融合到一起以稳定患部，可包括部分或全部切除和/或替代患部骨组织。可插入骨板或其它假体装置，以消除两骨部分间的不对等运动，便于进行关节融合术。
尤其对于承重骨，重要的是假体装置不应通过应力屏蔽新骨生长，并允许骨部分或相邻椎骨间变弱关节或假关节融合。已知对于承重骨部件，新骨在压力下生长可产生更强更密的骨组织。问题是何时和如何确定骨部分间产生强健关节所需的压力或力的量。骨生长时应固定和支撑骨部分。但是，随着骨部分间骨关节或骨桥的形成，骨生长所需的最佳支撑随时间而改变。
类似地，通过先固定/固定化韧带来治疗拉长和/或撕裂的韧带。这可通过以下方法实现：使用内部和外部假体装置中的一者或两者来增强或代替由于韧带损伤而失去的稳定性。而且，韧带一旦损伤，容易再次损伤。因此，需要通过植入假体或装置，允许患部脊柱组件有限运动，同时防止组件过分运动而导致新损伤的再次损伤，以增强待治疗韧带。目前的治疗方法不是让植入装置先固定或固定化韧带，然后允许该韧带的有限运动而无需后续外科手术。
鉴于上述内容，不断需要用于矫形装置、新型矫形装置的材料，使用这些材料的治疗，以稳定和支撑受损骨组织、骨结构和结缔组织。还需要提供给生长骨可变负荷的材料，以及为损伤或易患病骨和结缔组织提供柔性支撑的量度。本发明解决了这些需要，并以新颖且非显而易见的方式提供了其它益处和优点。
发明概述
本发明涉及各向异性复合材料，用于构建矫形装置，以及这些装置的生产和使用。本发明各方面是新颖、非显而易见的，提供了多种优点。虽然只能参考所附权利要求书确定本发明覆盖的实际范围，具有本文所述优选实施方式特征的某些形式和特点简要叙述如下。
在一种形式中，本发明提供各向异性复合材料，用于构建矫形装置。该复合材料包含：被构造成可稳固固定于两个或多个骨部分的生物稳定柔性纤索，允许骨部分的第一个相对于骨部分的第二个平移、旋转或平移加旋转运动。更具刚性和更易生物降解的材料与纤索啮合，使得可生物降解材料限制了骨部分的第一个相对于固定于复合材料的骨部分的第二个的平移、旋转或平移加旋转运动。
可使用复合材料构建矫形装置，用于治疗各种骨缺损，包括但不限于，骨折、患病骨组织、脊柱疾病、患病/受损椎骨、韧带撕裂或拉长等。
在优选的实施方式中，含复合材料的装置防止，或至少降低新形成的骨组织的应力屏蔽。在其它实施方式中，本发明矫形装置可被构造成人工关节。在这些实施方式中，复合材料可允许有限量的运动，即绕关节平移和/或旋转。含或不含可生物降解材料的装置仍然是贴附于含复合材料装置的骨部分运动的支撑和/或限制量度。在优选的实施方式中，本发明装置无限期地固定不动。
其它目的、特点、方面、形式、优点和益处在说明书中将显而易见。
附图简要说明
图1是本发明复合材料部分剖开的透视图，包括具有缠绕纤丝且包裹在可生物降解基质中的细长纤索。
图2是本发明另一个实施方式的细长复合材料的部分剖开的透视图。
图3是根据本发明，由至少一根可生物降解纤丝支撑的多根非生物降解纤丝的透视图。
图4是包括多根非生物降解纤丝的纤索的透视图，至少一根纤丝被包裹在可生物降解基质中。
图4A是一根被包裹在图4所示纤索的可生物降解基质中的纤丝的剖面图。
图5是具有骨缺损的骨透视图，已采用图1、2或3所示纤索之一制备的矫形装置治疗。
图6显示一个实施方式的复合材料，包含嵌入可生物降解聚合物基质中的网状材料。
图7是根据本发明，一个实施方式的复合材料的剖面图，包含嵌入两个可生物降解基质之间的非生物降解布。
图8是根据本发明，另一个实施方式的包裹在两个可生物降解基质之间的织物的剖面图。
图9是具有缺损的脊柱区段的透视图，已用本发明复合基质治疗。
优选实施方式的描述
为促进对本发明原理的理解，将参考本文所述实施方式，并采用具体语言描述本发明。但是，应理解这不是为了限制本发明的范围。涵盖了本文所述装置、系统和治疗方法的任何变化和进一步改进，以及本文所述本发明原理的进一步应用，就如本发明相关领域技术人员通常所理解的那样。
在优选的实施方式中，本发明提供一种复合材料，用于构建可植入矫形装置或假体，以促进缺损骨结构和/或结缔组织的支撑和修复。缺损骨结构可以是损伤、创伤和/或患病组织的结果。通过使用术语“矫形装置”，其含义包括用于治疗或修复肌肉/骨骼系统缺损、患病或受损组织的装置或植入物。
本发明可生物降解材料提供一种包含支撑基质的复合材料，和用于可植入矫形装置的纤索。该支撑基质提供刚性，支持植入的矫形融合装置，以及后续贴附的骨结构。使用时，复合材料和/或含复合材料的矫形装置所支撑的生物机械负荷随时间变化。这就使得矫形装置变成动态的，或在体内改变其物理性质。这种物理性质的改变对于在骨缺损或融合部位形成强壮的新骨组织尤其重要。这防止了新骨向内生长的应力屏蔽，并最大程度地降低了形成假关节的风险。
在一种形式中，无需采用后续治疗，基质的降解可自然发生。在其它形式中，可在植入后选定或预定的时间引发(或触发)、诱导和/或完成基质的降解。装置和/或复合材料可包括易受辐射能量、光(UV)、具有不同pH水平的溶剂、热量或温度影响或对其敏感的聚合物，以引发降解。治疗可包括侵入性和非侵入性治疗。优选地，采用插入装置(或复合材料)近端的UV辐射探针完成治疗。
以下叙述具体描述了本发明的非限制性具体实施方式。
图1是一个实施方式的复合材料10的透视图，包括纤索12和基质14。纤索12可以是单根细长纤丝16，或是多根纤丝18a，18b和18c，...，合称为纤丝18。若纤索12是单根纤丝，它可以是包裹在基质14内的大直径杆或实体芯。植入物10具有纵轴20。在优选的实施方式中，纤索16和/或各纤丝18a，18b，18c，基本上在纵轴20方向延伸。虽然应理解，一般在纵轴20方向延伸的各纤丝18a，18b，18c，...中的一根或多根可绕该方向缠绕且基本上垂直延伸，或在植入物10中的任何给定位置以一定角度倾斜。在其它实施方式中，多根纤丝18a，18b，18c，...可缝编在一起，形成平面纤丝网或三维纤丝网。
基质14可基本上包裹纤索12。或者，至少一部分纤索12可延伸通过或超过基质14表面。基质14提供支撑，以维持矫形装置的所需形状。因此，基质14可以是多种可生物降解材料。一些材料可容易地在手术室中形成，例如，通过加热材料和使复合材料形成所需构型，以配合骨缺损和/或诱导骨缺损保持所需构型。或者，可由供应商或制造商预先形成或定形基质14。所示基质14基本上为圆柱细长构型。应理解基质14可以是任何所需构型，包括基本上弯曲、平面或扁平构型。或者，基质14可以是任何所需形状，包括基本上为球形、正方形、矩形或无定形的构型，如上所述，这些构型在升高的温度下或在诸如光、湿度或溶剂激活的其它条件下，可用手或不可用手塑造。
在可选的实施方式中，基质14与纤索12相结合。可使用生物相容的化学粘合剂将基质和纤索12结合在一起。结合也可以是基质14和纤索12之间的机械互锁。
虽然所示复合材料10是细长圆柱体，应理解包括其它构型，且包括在本发明的范围内。例如，需要时，复合材料10可以是弯曲、平面、立方体、球形或无定形形状。而且，复合材料10(和纤索12)包括可将其固定于骨组织的多种结构。多种结构的例子非限制性地包括：眼孔、环、钩、骨紧固件、销、钉、粘固剂、胶及其组合。
纤索12延伸通过至少一部分基质14。纤索12可由许多在基质14中相互分离或直接相互接触或松散地捆在一起的单纤丝形成或组成。纤丝18a，18b，18c，...可编织或缝编在一起，延伸至少部分通过基质14。或者，纤丝18a，18b，18c，...可相互平行地延伸通过至少一部分基质14。在其它实施方式中，纤索12和/或纤丝可基本上嵌在基质14中或完全被基质14包围，使得没有纤索或纤丝部分暴露在外或肉眼可见。
纤丝18a，18b，18c，...各自由相同材料形成和/或具有相同形状、直径和长度。或者，需要时，18a，18b，18c，...中的一根或多根可以是不同材料，或为不同形状、直径、长度或构型。如果纤丝18a，18b，18c，...各自为不同材料，形状和大小可诱导植入物产生不同的所需物理性质，从而制备适于治疗个体矫形缺损或疾病的矫形植入物。
在一个实施方式中，纤索12为弹性和/或柔性。因此，纤丝18a，18b，18c，...中的一根或多根可为弹性或柔性材料。将纤丝18a，18b，18c，...缝编在一起可改进纤索的弹性或柔性。例如，采用松散缝编或紧密缝编，各纤丝18a，18b，18c，...之间可存在不同大小的间隔24，使纤索12具有不同程度的柔性。
纤索12(和纤丝18a，18b，18c...)可具有光滑外表面。或者，纤索12(和纤丝18a，18b，18c...)可以是粗糙麻面、凹陷或隆起的表面。纤索12的变形外表面可单独通过机械互锁机制或与粘合剂联合，促进基质材料与纤索的结合。构成纤索12的纤丝18a，18b，18c...的三维网络可包括空隙或间隔，也可促进基质材料14与纤索12通过机械互锁机制的结合。此外，可处理基质14或纤索12的表面以促进良好粘着。这种表面处理包括电晕放电、等离子体放电、化学蚀刻、电子或离子束辐射、激光辐射以及本领域已知的其它方法。
纤索12可以是非生物降解材料。非生物降解材料的例子如下详细所述。此外，纤索12可包括一根或多根独立的纤丝，由可生物降解材料组成。纤丝的可生物降解材料可组成形状记忆聚合物和/或其它生物相容聚合材料。
在一个优选的实施方式中，基质14由可生物降解材料22组成。在体内，基质14溶蚀或生物降解。随着基质14的生物降解，复合材料10的刚性降低。在优选的实施方式中，这种刚性基本上是随时间线性降低的。如下详细所述，基质14的性质和组成可变化，以使基质14在不同时间内降解，包括几天、几周、几个月、甚至一年或几年的时间。可配制基质14，使其具有所需的体内半衰期。使用术语“半衰期”，表示在特定时间段内，基质14降解至约其原始质量的一半。在一个优选的实施方式中，基质14的体内半衰期小于约6个月；更优选基质14的半衰期小于约12个月；还要更优选基质14的半衰期小于约18个月。在其它实施方式中，可配制基质14，使其半衰期大于或等于一年；更优选大于或等于18个月。
图2是本发明另一个实施方式的细长复合材料30的透视图。细长复合材料30具有中轴35。复合材料30包括基质32和插入基质32且通常沿轴35延伸的纤索34。纤索32可包括单纤丝36a或多根纤丝36a，36b，36c，...，合称为纤丝36。在所示实施方式中，纤丝36a，36b，36c，...缝编在一起形成纤索34。
通常，复合材料30基本上如上文复合材料10所述，包括对基质22和/或纤丝18a，18b，18c，...的描述。缠绕纤丝36a，36b，36c，...可提供与编织纤丝18a，18b和18c所显示的不同的性质，包括在其中形成中央腔38的能力。中央腔38基本上平行于轴35延伸。在一个实施方式中，中央腔38基本上填充有基质34材料。在其它实施方式中，另一根纤丝或纤索可延伸通过中央腔38。实际上，纤丝36a，36b，36c，...可围绕中央纤索或纤丝缠绕。中央纤索或纤丝可与纤索34或纤丝36相同或不同。此外，缠绕纤丝36a，36b，36c，...也可在各纤丝之间，例如纤丝36a和36b之间产生附加的间隔或间隙40。在另一些实施方式中，腔38可填充有治疗剂或成骨材料。
图3是本发明一个实施方式的复合材料49的透视图，包括系链或纤索50。纤索50包括多根通常沿中轴51延伸的纤丝。在优选的实施方式中，纤索50包括第一组纤丝52和至少第二组纤丝54。纤索50中也可包括其它组或单根纤丝。在所示实施方式中，第一组纤丝52包括多根单纤丝56a，56b，56c...。纤丝56a，56b，56c...可以是相同的纤丝，且具有相同的长度或构型。或者，选定的一根或多根纤丝56a，56b，56c...在组成、物理性质、大小、直径、长度等方面可与其它纤丝不同。第一组纤丝52基本上如对纤丝18(以及纤索12)的描述。此外，应理解，纤丝56a，56b，56c...的相对排列可为多根平行纤丝、缠绕纤丝、编织纤丝等。一根或多根纤丝56a，56b，56c...可以是由非生物降解材料形成的基本上呈刚性的纤丝，如下更详细所述。
纤索50还包括第二组纤丝54。第二组纤丝54可包括单根纤丝58或具有类似于第一组纤丝52所述排列的多根纤丝。
纤丝58可由可生物降解材料组成，如下更详细所述。此外，纤丝58可以是基本上呈刚性的纤丝，给纤索50提供支持和/或进一步支持第一组纤丝52中的各个纤丝。在所示实施方式中，纤丝58可基本上交织或缝编成多根纤丝56a，56b，56c...。在其它实施方式中，纤丝58可基本上沿平行于一根或多根第一组纤丝52的方向延伸，卷绕一根或多根第一组纤丝52，和/或螺旋缠绕在第一组纤丝52内。纤丝58可以所需降解速率或在所需时间内在体内降解。可调节纤丝58的降解速率或半衰期，以适于纤索50的特定需要、治疗和/或应用。在一个实施方式中，选择纤丝58的半衰期大于约6个月；更优选大于或等于约1年；还要更优选大于或等于约18个月。在其它实施方式中，纤丝58的半衰期小于约1年。而且，纤丝58可具有与第一组纤丝52中的各个纤丝和/或一根或多根纤丝56a，56b，56c...基本上相同的构型、长度、直径、质量和/或拉伸强度。
使用时，随着第二组纤丝54在体内的降解，纤索50和/或一根或多根第一组纤丝52的刚性降低。这就使得纤索50和/或一根或多根第一组纤丝52变得更具柔性。因此，如果纤索50和/或第一组纤丝52贴附的骨部分铰接，柔性或随时间增加的柔性使得关节随着骨组织的生长而增加移动，矫正了缺损。应理解，在优选的实施方式中，即使减去一些或全部第二组纤丝54，纤索50仍然固定于骨部分。而且，应理解在其它方面，纤索50基本上如上文纤索12和34所述。
图4是本发明另一个实施方式的复合材料70的透视图，用于形成矫形装置。复合材料70包含纤索72，纤索72包含第一组纤丝74和至少第二组纤丝76。第一组纤丝74基本上如上文对纤索50的第一组纤丝52所述，包含多根独立的纤丝75a，75b，75c...。第二组纤丝76可包含一根、两根、三根或更多根纤丝，合称为纤丝78。再参考图4A，纤丝78包含至少一个由可生物降解材料组成的外涂层或基质80和内芯材料77，如下更详细所述，需要时，内芯材料77可包含大直径杆、实体芯、较细的线、纤丝、编织物或多根纤丝中的一种。在一个实施方式中，内芯材料77可包含类似于第一组纤丝74所定义的纤索纤丝。或者，内芯材料77可与纤丝75a，75b，75c，..中的任一根相同或不同。此外，芯77可由可生物降解材料和/或非生物降解材料构成，如下更详细所述。包含芯材料77和基质80的纤丝78可基本上具有刚性或提供给纤索72刚性。
体内，随着包含可生物降解材料的基质80开始溶蚀，纤丝78和/或芯77的刚性降低。因此，纤索72的刚性降低。这就使得植入物贴附的骨部分铰接或负载越来越多的负荷，以促进硬皮质骨组织的形成和防止假关节。在其它方面，纤丝78的刚性、大小、构型、直径、半衰期等基本上如上文纤丝58或纤索50中任一项所述。此外，纤索72可包裹或基本上包裹在基质内，例如复合材料10或30的基质14或32。
一根或多根纤丝75a，75b，75c和纤丝78可捆在一起，在其中形成内部区域82。内部区域可以是空隙，包含基质材料或治疗剂、成骨材料或另一多根纤丝组成的纤索，如上文腔38所述。在其它实施方式中，多根纤丝75a，75b，75c，...可缝编在一起，形成平面纤丝网或三维纤丝网。
图5是一个实施方式中，具有缺损92的骨90的透视图。所示由细长复合材料95组成的矫形植入物94贴附于骨90且横跨缺损92。矫形植入物94可由复合材料组成，如上文复合材料10，30，70或者纤索50或72中任一项所述。在所示实施方式中，矫形植入物94包括基本上包裹纤索98的外部基质96。纤索98包括第一纤丝100和第二纤丝102。可通过本领域常用和/或已知的任何方式，包括但不限于骨锚104a，104b，104c和104d，肘钉、钢纤丝、缆纤索等，将矫形植入物94贴附于骨部分。由图可见，一些骨锚如104a和104d可单独延伸通过纤索98，穿过或不穿过基质96。其它骨锚如104b和104c可延伸通过外部基质96，接触或不接触纤索98。使用时，外部基质96在体内缓慢降解。降解后，植入物的残留部分即纤索98仍然固定于骨部分，提供附加的支撑和/或限制。但是，如上和如下更详细所示，外部基质96的降解使得对缺损92内新骨生长产生越来越大的应力。这就提供较佳的骨组织生长条件，以确保坚硬、稠密的皮质骨生长入缺损中。此外，骨缺损中可加入成骨材料，单独提供或与外部基质组合，和/或掺入纤索中。
图6是本发明使用的另一个实施方式的复合材料120的透视图。复合材料120包括缝编纤索或纤索阵列，提供网122和基质124。网122可为平面(二维)、织物、布样材料或三维网络。基质124的形成类似于上述基质96，80和14。因此，基质124可为可生物降解或可生物溶蚀材料，给由复合材料120形成的矫形植入物提供刚性支持。
网122可包括第一组纤丝126和至少第二组纤丝128。在所示实施方式中，第一和第二组纤丝126和128基本上相互垂直。本领域技术人员将明白，可按需要提供第一组纤丝126相对于第二组纤丝128的取向，包括基本上相互平行、缝编、编织、或以一定角度相互倾斜。而且，第一组纤丝126和第二组纤丝128可包括基本上相同的材料或包括不同的材料。而且，第一组纤丝126和第二组纤丝128可具有基本上相同的性质，包括拉伸强度、直径、长度、形状等；或者，这两组纤丝可具有彼此不同的拉伸强度、直径、长度、形状等。此外，第一组纤丝126基本上如上述第一组纤丝74和/或第一组纤丝52.。类似地，第二组纤丝128基本上如上述第一组纤丝74和52，或第二组纤丝76和/或54。
第一组纤丝126和第二组纤丝128可相互配合或固定。需要时，配合可为以下形式：用或不用胶粘结、缝编在一起、打结在一起、彼此顶面上方覆盖塑模，或通过机械互锁机制。
在所示实施方式中，第一和第二组纤丝126和128各自基本上包裹在基质124内。应理解，第一组纤丝126和第二组纤丝128中的一根或多根、或两者同时暴露或至少部分暴露在基质124之外。
第一组纤丝126可包括多根纤丝127a，127b，127c，...，每根纤丝由相同材料组成和/或显示相同物理性质、大小和形状。或者，需要时，纤丝127a，127b，127c，...各自可为不同材料或不同大小、形状或物理性质。
类似地，构成第二组纤丝128的纤丝129a，129b，129c，...各自可为相同材料和/或相同物理性质和大小，或者，需要时，它们可为不同材料、大小和/或物理性质。
在另一个实施方式中，第一组纤丝126和第二组纤丝128由不同材料组成和/或具有不同物理性质、大小和形状。这可用于制备具有各向异性的矫形基质，即不同方向上显示不同性质。例如，第二组纤丝128可包含可生物降解或非生物降解材料。例如，第一和第二组纤丝126和128都可由可生物降解材料组成，它们可以是相同或不同的第二种材料。两种材料的降解速率或半衰期不同。
或者，第一组纤丝126可由可生物降解材料组成，而第二组材料可由非生物降解材料组成。因此，当第一组纤丝126溶蚀时，体内仍然保留第二组纤丝l28。
在又一个实施方式中，第一组纤丝126中纤丝的大小和/或性质可与第二组纤丝128中的纤丝不同。一组纤丝在体内可保留较长的时间。
这就提供了具有多种性质的矫形植入物，可调节性质以适合矫形缺损上的具体应用和治疗方法。
基质124可为可塑模或可成形材料，该材料在体内和室温下和/或药理学条件下具有刚性。但是，需要时，可在特定溶剂中或特定条件下配制基质124，使得在升高的温度下可用手或机器塑模。例如，基质材料124可包括一种或多种可交联聚合物材料，使得一旦受到引发，基质材料就可形成具有所需或预定构型的交联基质。可用胶或不用胶，通过上方塑模或通过机械互锁机制固定，将基质材料124粘结或固定于第一组纤丝126和/或第二组纤丝上。
图7是本发明一个实施方式的复合材料140的剖面图。复合材料140基本上如上文复合材料120所述。或者，复合材料140可与上述材料不同。例如，复合材料140可包括第一基质142和至少第二基质144。第一和/或第二基质可由相同或不同的材料构成。例如，第一基质142可由第一可生物降解材料形成，第二基质144可由第二可生物降解材料形成。此外，松散织物或布样材料包括第一组纤丝150和第二组纤丝152。织物或布样材料146可位于第一基质142和至少第二基质144之间。织物或材料146基本上如上述网122。在选定的实施方式中，第一基质142和第二基质144中的一者或两者可与缝编材料146，更具体地说是包含缝编材料146的纤丝粘结、上方塑模或配合。在其它实施方式中，可用生物相容粘合剂将第一基质和/或第二基质胶粘于一个或多个缝编材料146和/或纤维148。
再参考图8，显示了复合材料160。复合材料160类似于上文所述复合材料140。因此，相同的标号用于表示相同的组件。复合材料160包括第一基质142和第二基质144以及它们之间的缝编材料146。另外，显示了缝编或缝合方式的第三组纤丝162，将第一基质142、第二基质144和缝编材料146结合到一起。第三组纤丝162基本上如上文第一组纤丝74，52，36和18所述。或者，第三组纤丝162如上文第二组纤丝77和58所述。在又一个可选的实施方式中，可通过任何本领域常用或已知的方式将第一基质142、第二基质144和缝编材料146紧固在一起，包括纤索、束带、纤丝、肘钉、夹片、系带、胶带、胶、粘固剂以及它们的组合。
图9显示了具有缺损的脊柱170的一部分，包括第一椎骨172和第二椎骨174。可用矫形装置176治疗骨缺损。矫形装置176可包括诸如上述复合材料160，140和/或120的材料。使用时，矫形装置176的可生物降解组分发生降解，残留组分即缝编基质和/或一部分缝编基质仍然固定于第一和第二椎骨172和174中的一者或两者。这就使得两椎骨相互铰接，但保持完整性并限制运动或允许脊柱有限运动。
一个或多个纤索、纤丝和/或基质中的可生物降解材料可由上述多种材料形成或组成，包括但不限于，可降解或可吸收聚合材料、复合材料和陶瓷材料。
在一个实施方式中，可生物降解材料包括由寡聚物、均聚物、共聚物和聚合物混合物形成的复合材料，包括来自l，d或d/l丙交酯(乳酸)；乙交织(乙交织)；醚；氨基酸；酸酐；原酸酯；羟酯；以及这些单体重复单元的混合物的聚合单体。
所用术语“共聚物”在本发明范围内意在包括由两种或多种独特的单体重复单元形成的聚合物。这种共聚物包括随机共聚物；接枝共聚物；主体共聚物；径向共聚物、二聚体和三聚体共聚物；交替共聚物；和周期共聚物。所用术语“共聚物混合物”意在包括聚合物合金、半贯通聚合物网(SIPN)和贯通聚合物网(IPN)。
在优选的实施方式中，可生物降解材料包括含以下成分的可生物降解材料：聚(氨基酸)、聚酐、聚己内酯、聚(乳酸-乙醇酸)、聚羟基丁酸酯、聚原酸酯和聚(d，l-丙交酯)。
在其它实施方式中，可生物降解材料包含可生物降解陶瓷材料和陶瓷粘固剂。可生物降解陶瓷材料的例子包括：羟基磷灰石、羟基磷灰石碳酸酯、海藻提取物(corraline)、磷酸钙、磷酸三钙(tricalcium phosphatem)和羟基磷灰石颗粒。可生物降解陶瓷粘固剂的例子包括磷酸钙粘固剂。这种磷酸钙粘固剂优选是合成磷酸钙材料，包括差或低结晶磷酸钙，例如差或低结晶磷灰石，包括羟基磷灰石，得自Etex Corporation，例如美国专利5,783,217、5,676,976、5,683,461、5,650,176和PCT国际公开WO 98/16268、WO 96/39202和WO 98/16209所述，所有都授权于Lee等。使用术语“差或低结晶”表示包括具有很小或没有长程秩序的无定形材料，和/或显示纳米级或埃级晶体域的纳米晶体材料。
在又一些实施方式中，可生物降解材料可由复合材料形成。作为基础材料或基质的复合材料的例子包括但不限于：陶瓷、可吸收粘固剂和/或上述可生物降解聚合物。这些基础材料各自可浸渍或分散有纤维、板状物和微粒增强材料。
在一种形式中，可生物降解材料包括可吸收、可塑模材料，它们在升高的温度下塑模，然后约在体温下形成坚硬材料，例如WO 98/40133所述以商品名BIOGLASS销售的材料，其内容被纳入本文作为参考。
通过适当选择大小、厚度和/或可生物降解材料调节本发明复合材料，使其以预定或预先选定的速率降解。在优选的实施方式中，可生物降解材料以相当于新骨向内生长进入骨缺损或骨融合部位的速率降解。在尤其优选的实施方式中，刚性可生物降解组分的体内半衰期大于3个月，更优选限制性组分的体内半衰期大于6个月；还要更优选体内半衰期大于1年。通过使用术语“半衰期”，应理解限制性组分的降解速率是假定由于吸收、降解和/或消除，限制性组分在体内损失其起始质量一半时的速率。
而且，可配制可生物降解材料自发降解，或通过应用外部刺激诱导降解。例如，一旦应用辐射，例如UV辐射、热量和/或溶剂(中性、碱性或酸性)，可生物降解材料开始降解。
本发明中使用的非生物降解或生物稳定材料包括回弹材料，例如但不限于，镍钛合金、钛、钛-钒-铝合金、钴-铬合金、钴-铬-钼合金、钴-镍-铬-钼合金、生物相容不锈钢、钽、铌、铪、钨以及它们的合金；聚合材料包括来自以下的聚合单体：烯烃，例如乙烯、丙烯、丁烯-1、戊烯-1、己烯-1，4-甲基戊烯-1、苯乙烯、降冰片烯等；丁二烯；多功能单体如丙烯酸酯、甲基丙烯酸酯、甲基丙烯酸甲酯；酯，例如己内酯和羟酯；以及这些单体重复单元的混合物。本发明中使用的聚合物优选包括碳聚(醚，醚，酮)(PEEK)、聚(芳醚，酮)(PAEK)等。
此外或作为替代方式，需要促进任一侧骨缺损上相邻椎骨间或任何骨部分间的骨融合。在该实施方式中，需要包含成骨材料或骨生长材料如骨诱导或骨传导材料。例如，需要引入成骨因子如骨形态形成蛋白(BMP)或可操作地与启动子相连接的编码该蛋白的基因，驱使该基因在动物受体中的表达，从而产生有效量的蛋白。本发明骨形态形成蛋白(BMP)是能够刺激成骨细胞和破骨细胞分化和发挥功能的任何BMP。这种BMP的例子有BMP-2、BMP-4和BMP-7，更优选rhBMP-2或rhBMP-7、LIM矿化蛋白(LMP)或可操作地与启动子相结合包含编码该蛋白的基因的合适载体，如WO99/06563中所述(也可参见Genbank登录号AF095585)。
本发明复合材料和矫形装置可单独使用或与一种或多种已知的医用矫形装置联合使用。此外或作为替代方式，本发明可与一种或多种共同待批的专利申请中所述的装置：2003年10月21日提交的题为“允许脊柱构建物动态平移的设备和方法”(″Apparatus and Method for Providing Dynamizable Translation toa Spinal Construct，″)的美国专利申请序列号10/689,981和2003年10月21日提交的题为“动态矫形植入物及其在治疗骨缺损中的应用”(″DynamizableOrthopedic Implants and Their Use in Treating Bone Defects.″)的申请序列号10/690,451。
在优选的实施方式中，本发明复合材料可提供给选定的骨结构最初的支持和/或固定。选定时间后或特定条件下，支持/固定的量和性质可变化，以促进所需的治疗。例如，使用本发明复合材料允许可变或动态支持形成新的强壮骨组织，从而尽可能减小假关节的风险。
本发明复合材料也适用于治疗结缔组织如韧带。例如，含复合材料的装置可增强结缔组织。预定时间后或预定条件下，复合材料允许与含复合材料的矫形装置贴合的结缔组织和/或骨结构有限平移、旋转或平移加旋转运动。例如，若天然结缔组织为弹性的，复合材料可用于限制或抑制结缔组织伸展的总长度或总量。这种限制可根据用于形成构建和使用装置的复合材料的时间长短或预选定条件而改变。
虽然附图和上述内容中详细说明和描述了本发明，这些内容是示例性而非限制性的，应理解只显示和描述了优选实施方式，需要保护本发明范围内的所有改变和改进。应理解任何具体方向的标号，例如，上、高、下、低等标号仅出于示例性的目的，或是为了更好地鉴定和识别各组件。不应将这些标号解释为以任何方式限制本文所述矫形装置和/或使用该矫形装置的方法。
并且，本说明书所引用的所有出版物、专利和专利申请被纳入本文作为参考，就如同各个出版物、专利或专利申请具体且独立地以其全部内容被纳入本文作为参考。
除非具体指出不同情况，本文所用所有术语包括其一般和习惯用法。而且，虽然本文描述和说明了多个实施方式的具有特定组件和结构的医用装置，应理解，可能的话，任何选定的实施方式可包括一个或多个另一个实施方式所述的特定组件和/或结构。
并且，本文所述任何操作理论、证据或发现是为了进一步促进本发明的理解，而不是为了根据这些理论、证据或发现限制本发明的范围。

Claims (86)

1.一种用于矫形装置的复合材料，所述复合材料包括：
包含非生物降解材料的柔性纤索；和
包含可生物降解材料的刚性基质，所述刚性基质与所述柔性纤索相接触，使得所述刚性基质限制所述纤索的柔性。
2.如权利要求1所述的复合材料，其特征在于，所述基质包裹所述纤索。
3.如权利要求1所述的复合材料，其特征在于，所述基质与所述纤索粘结。
4.如权利要求1所述的复合材料，其特征在于，所述纤索具有粗糙、有凹痕、有槽或隆起的外表面。
5.如权利要求4所述的复合材料，所述基质通过机械互锁固定于所述纤索。
6.如权利要求1所述的复合材料，其特征在于，所述纤索具有经过处理的外表面，以促进所述基质的粘附。
7.如权利要求1所述的复合材料，其特征在于，所述纤索延伸通过所述基质。
8.如权利要求1所述的复合材料，其特征在于，所述纤索从所述基质内部延伸至所述基质外部。
9.如权利要求1所述的复合材料，其特征在于，所述纤索由一根细长的纤丝构成。
10.如权利要求1所述的复合材料，其特征在于，所述纤索包括多根编织在一起的细长纤丝。
11.如权利要求1所述的复合材料，其特征在于，所述纤索包括多根缠绕在一起的细长纤丝。
12.如权利要求1所述的复合材料，其特征在于，所述纤索包括多根缝编在一起的细长纤丝，形成平面纤丝网或三维纤丝网。
13.如权利要求1所述的复合材料，其特征在于，所述非生物降解材料包括选自下组的材料：聚(醚，醚，酮)、聚(芳醚)、聚(芳基醚酮)聚醚、聚酐、聚烯烃、聚丙烯酸酯、聚甲基丙烯酸酯、聚甲基丙烯酸甲酯、聚酯以及它们的共聚合和混合物。
14.如权利要求1所述的复合材料，其特征在于，所述可生物降解材料包括选自下组的材料：聚(氨基酸)、聚酐、聚己内酯、聚乳酸酯、聚乙醇酸酯、聚(乳酸-乙醇酸)、聚原酸酯、羟基磷灰石碳酸酯、海藻提取物、磷酸钙、磷酸三钙以及它们的混合物。
15.如权利要求1所述的复合材料，其特征在于，所述可生物降解材料具有起始质量，并在约一年内在体内生物降解至小于或等于其起始质量的大约一半。
16.如权利要求1所述的复合材料，其特征在于，所述可生物降解材料具有起始质量，并在一年以上的时间内在体内保留其起始质量的一半以上。
17.如权利要求1所述的复合材料，还包括：
骨生长材料，其中所述刚性基质浸渍有所述骨生长材料以促进关节融合。
18.如权利要求1所述的复合材料，还包括：
骨生长材料，其中所述纤索浸渍有所述骨生长材料以促进关节融合。
19.如权利要求1所述的复合材料，其特征在于，所述纤索还包括用于将所述含所述复合材料的矫形装置稳固地固定于骨部分的非生物降解结构，其中所述结构选自：眼孔、环、钩、骨紧固件、销、钉、粘固剂、胶及其组合。
20.如权利要求1所述的复合材料，其特征在于，所述矫形装置贴附于骨部分，随着所述刚性基质在发生生物降解，至少一些所述矫形装置上的负荷转移至骨部分。
21.如权利要求1所述的复合材料，其特征在于，所述矫形装置贴附于骨部分，所述刚性基质生物降解后，所述矫形装置允许所述骨部分有限平移、旋转或平移加旋转运动。
22.如权利要求1所述的复合材料，其特征在于，所述纤索包括多根基本上相互平行排列的细长纤丝。
23.如权利要求22所述的复合材料，其特征在于，所述细长纤丝固定在一起。
24.一种制造固定骨部分的矫形装置的方法，所述方法包括：
提供如权利要求1所述的复合材料；和
将所述复合材料包含入所述矫形装置，使得所述复合材料限制贴附于所述矫形装置的骨部分的运动。
25.如权利要求24所述的方法，其特征在于，所述矫形装置被构造成骨板形。
26.如权利要求24所述的方法，其特征在于，所述矫形装置被构造成杆形。
27.如权利要求24所述的方法，其特征在于，所述复合材料包含入所述矫形装置中，使得所述刚性基质生物降解之前或之后，所述复合材料限制贴附于所述矫形装置的骨部分平移、旋转或平移加旋转运动。
28.一种治疗骨缺损的方法，所述方法包括：
构建包含权利要求1所述复合材料的矫形装置，
将所述矫形装置贴附于两个或多个骨部分，使得所述复合材料中的所述刚性基质限制贴附于所述矫形装置的两个或多个骨部分的运动。
29.一种用于矫形装置的复合材料，所述复合材料包括：
包含第一组细长纤丝和第二组细长纤丝的缝编材料，所述纤丝由非生物降解材料构成；和
包含可生物降解材料的刚性基质，用所述刚性基质覆盖所述缝编材料，使得所述基质限制所述第一组细长纤丝相对于所述第二组细长纤丝的运动。
30.一种复合材料，所述复合材料包括：
多根各自由非生物降解柔性材料构成的柔性细长纤丝；和
多根各自由可生物降解材料构成的刚性细长纤丝，其中，所述柔性细长纤丝和所述刚性细长纤丝相互啮合，使得所述刚性细长纤丝限制所述柔性细长纤丝的运动。
31.如权利要求30所述的复合材料，其特征在于，所述柔性细长纤丝和所述刚性细长纤丝编织在一起。
32.如权利要求30所述的复合材料，其特征在于，所述柔性细长纤丝和所述刚性细长纤丝缠绕在一起。
33.如权利要求30所述的复合材料，其特征在于，所述柔性细长纤丝和所述刚性细长纤丝基本上相互平行排列。
34.如权利要求30所述的复合材料，其特征在于，所述柔性细长纤丝和所述刚性细长纤丝缝编在一起，形成柔性和刚性纤丝的平面或三维网络。
35.如权利要求30所述的复合材料，还包括：
连接组件，其中，所述柔性细长纤丝和所述刚性细长纤通过所述连接组件连接在一起，所述连接组件选自：纤索、束带、纤丝、肘钉、夹片、系带、胶带、胶、粘固剂以及它们的组合。
36.如权利要求30所述的复合材料，其特征在于，用生物相容粘合剂将所述柔性细长纤丝和刚性细长纤丝连接在一起。
37.如权利要求35所述的复合层，其特征在于，所述连接组件可生物降解。
38.一种复合材料，所述复合材料包括：
由可生物降解材料构成的第一组柔性纤索；
由可生物降解材料构成的第二组柔性纤索；和
比所述柔性纤索更容易生物降解的刚性基质，其中，所述第一组柔性纤索缝编在一起，所述第二组柔性纤索缝编在一起，所述第一组柔性纤索和所述第二组柔性纤索贴附于所述刚性基质。
39.一种复合材料，所述复合材料包括：
由刚性材料构成的第一组细长纤丝；
由柔性材料构成的第二组细长纤丝；和
体内具有第一降解速率的由可生物降解材料组成的刚性基质，其中，所述第一细长纤丝和所述第二细长纤丝缝编在一起形成网，并且所述刚性基质与所述网相啮合。
40.如权利要求39所述的复合材料，其特征在于，所述第一组细长纤丝包括选自下组的材料：镍钛合金、钛、钛-钒-铝合金、钴-铬合金、钴-铬-钼合金、钴-镍-铬-钼合金、生物相容不锈钢、钽、铌、铪、钨。
41.如权利要求39所述的复合材料，其特征在于，所述第二组细长纤丝包括选自下组的材料：聚(醚，酯，酮)、聚(芳醚)、聚(芳基醚酮)、聚醚、聚酐、聚烯烃、聚丙烯酸酯、聚甲基丙烯酸酯、聚甲基丙烯酸甲酯、聚酯以及它们的共聚合和混合物。
42.如权利要求39所述的复合材料，其特征在于，所述刚性基质包括选自下组的材料：聚(氨基酸)、聚酐、聚己内酯、聚乳酸酯、聚乙醇酸酯、聚(乳酸-乙醇酸)、聚原酸酯、羟基磷灰石碳酸酯、海藻提取物、磷酸钙、磷酸三钙以及它们的混合物。
43.如权利要求39所述的复合材料，其特征在于，所述刚性基质具有起始质量，并在约一年内在体内生物降解至小于或等于其起始质量的大约一半。
44.如权利要求39所述的复合材料，其特征在于，所述刚性基质具有起始质量，并在一年以上的时间内在体内保留其起始质量的一半以上。
45.如权利要求39所述的复合材料，其特征在于，所述第一组细长纤丝由可生物降解材料组成。
46.如权利要求45所述的复合材料，其特征在于，所述第一组细长纤丝显示与所述基质的第一降解速率不同的体内第二降解速率。
47.如权利要求39所述的复合材料，还包括选自以下结构的非生物降解结构：眼孔、环、钩、骨紧固件、销、钉、粘固剂、胶及其组合。
48.如权利要求39所述的复合材料，其特征在于，用生物相容粘合剂将所述刚性基质与所述第一组细长纤丝、或所述第二组细长纤丝或两者相粘结。
49.如权利要求39所述的复合材料，其特征在于，通过机械互锁将所述刚性基质与所述第一组细长纤丝、或所述第二组细长纤丝或两者相粘结。
50.一种用于矫形装置的复合材料，所述复合材料包括：
由生物稳定材料构成的第一组纤丝；
由可生物降解材料构成的第二组纤丝，所述第一组和所述第二组纤丝均匀缝编在一起，形成平面纤丝网或三维纤丝网。
51.一种用于矫形装置的复合材料，所述复合材料包括：
由生物稳定材料组成的第一片材；和
由可生物降解材料组成的第二片材，所述第一片材与所述第二片材相啮合，所述第二片材生物降解之前和之后，所述复合材料至少在一个方向上限制了稳固地固定于所述含所述复合材料的矫形装置的骨部分的运动。
52.一种用于矫形装置的复合材料，所述复合材料包括：
由可生物降解材料构成的第一片材；
由生物稳定材料构成的第二片材；和
用于将所述复合材料稳固地贴附于骨部分的结构，所述结构选自：眼孔、环、钩、骨紧固件、销、钉、粘固剂、胶及其组合。
53.如权利要求52所述的复合材料，其特征在于，当将所述含所述复合材料的矫形装置贴附于所述骨部分时，所述第一片材平行于所述骨部分的长轴贴附，所述第二片材垂直于所述骨部分的长轴贴附。
54.如权利要求52所述的复合材料，还包括：
由可生物降解材料构成的连接组件，所述连接组件将所述第一片材固定于所述第二片材，所述连接组件选自：纤索、纤丝、系带、肘钉、铆钉、螺母和螺栓组合件、胶、粘固剂以及它们的组合。
55.一种用于矫形装置的复合材料，所述复合材料包括：
柔性纤索，其包括含有非生物降解材料的芯；和
刚性基质，其包括围绕所述芯的可生物降解材料，所述刚性基质限制所述纤索的柔性。
56.如权利要求55所述的复合材料，其特征在于，所述纤索由一根纤丝或实体芯构成。
57.如权利要求55所述的复合材料，其特征在于，包括多根纤索。
58.如权利要求57所述的复合材料，其特征在于，所述多根纤索编织在一起。
59.如权利要求57所述的复合材料，其特征在于，所述多根纤索缠绕在一起。
60.如权利要求55所述的复合材料，其特征在于，所述纤索包括多根缝编在一起的细长纤丝，形成平面纤丝网或三维纤丝网。
61.如权利要求55所述的复合材料，其特征在于，所述非生物降解材料包括选自下组的材料：聚(醚，醚，酮)、聚(芳醚)、聚(芳基醚酮)聚醚、聚酐、聚烯烃、聚丙烯酸酯、聚甲基丙烯酸酯、聚甲基丙烯酸甲酯、聚酯以及它们的共聚物和混合物。
62.如权利要求55所述的复合材料，其特征在于，所述可生物降解材料包括选自下组的材料：聚(氨基酸)、聚酐、聚己内酯、聚乳酸酯、聚乙醇酸酯、聚(乳酸-乙醇酸)、聚原酸酯、羟基磷灰石碳酸酯、海藻提取物、磷酸钙、磷酸三钙以及它们的混合物。
63.如权利要求55所述的复合材料，其特征在于，所述可生物降解材料具有起始质量，并在约一年内在体内生物降解至小于或等于其起始质量的大约一半。
64.如权利要求55所述的复合材料，其特征在于，所述可生物降解材料具有起始质量，并在在一年以上的时间内在体内保留其起始质量的一半以上。
65.如权利要求55所述的复合材料，还包括骨生长材料，其中，所述刚性基质浸渍有所述骨生长材料以促进关节融合。
66.如权利要求55所述的复合材料，还包括骨生长材料，其中，所述纤索浸渍有所述骨生长材料以促进关节融合。
67.如权利要求55所述的复合材料，其特征在于，所述纤索还包括用于将所述含所述复合材料的矫形装置稳固地固定于骨部分的非生物降解结构，所述结构选自：眼孔、环、钩、骨紧固件、销、钉、粘固剂、胶及其组合。
68.如权利要求55所述的复合材料，其特征在于，所述矫形装置贴附于骨部分，随着所述刚性基质发生生物降解，至少一些所述矫形装置上的负荷转移至骨部分。
69.如权利要求55所述的复合材料，其特征在于，所述矫形装置贴附于骨部分，所述刚性基质发生生物降解后，所述矫形装置允许所述骨部分有限平移、旋转或平移加旋转运动。
70.如权利要求55所述的复合材料，其特征在于，所述纤索具有粗糙 有凹痕、有槽或隆起的外表面。
71.如权利要求55所述的复合材料，其特征在于，所述基质通过机械互锁固定于所述纤索。
72.一种用于矫形装置的复合材料，所述复合材料包括：
包含第一可生物降解材料的柔性纤索，其中，所述柔性纤索在第一时间段内在体内降解；和
与所述纤索接触的包含第二可生物降解材料的刚性基质，所述刚性基质限制所述纤索的柔性，其中，所述基质在不同于所述第一时间段的第二时间段内在体内降解。
73.如权利要求72所述的复合材料，其特征在于，所述第一可生物降解材料包括选自下组的材料：聚(氨基酸)、聚酐、聚己内酯、聚乳酸酯、聚乙醇酸酯、聚(乳酸-乙醇酸)、聚原酸酯、羟基磷灰石碳酸酯、海藻提取物、磷酸钙、磷酸三钙以及它们的混合物。
74.如权利要求73所述的复合材料，其特征在于，所述第二可生物降解材料选自：聚(氨基酸)、聚酐、聚己内酯、聚乳酸酯、聚乙醇酸酯、聚(乳酸-乙醇酸)、聚原酸酯、羟基磷灰石碳酸酯、海藻提取物、磷酸钙、磷酸三钙以及它们的混合物，且不同于所述第一可生物降解材料。
75.如权利要求73所述的复合材料，其特征在于，所述纤索形成芯，所述基质包围所述芯。
76.如权利要求73所述的复合材料，其特征在于，包括多根柔性纤索。
77.如权利要求76所述的复合材料，其特征在于，所述多根柔性纤索编织在一起。
78.如权利要求76所述的复合材料，其特征在于，所述多根柔性纤索缠绕在一起。
79.如权利要求76所述的复合材料，其特征在于，所述柔性纤索包括第一组柔性纤丝和第二组柔性纤丝，其中，所述第一组柔性纤丝和所述第二组柔性纤丝缝编在一起，形成平面纤丝网和三维纤丝网。
80.如权利要求79所述的复合材料，其特征在于，所述第一组柔性纤丝包含第一可生物降解材料，所述第二组柔性纤丝包含与所述第一材料不同的第二可生物降解材料。
81.如权利要求80所述的复合材料，其特征在于，在体内，所述第一组柔性纤丝在第三时间段内降解，所述第二组柔性纤丝在不同于所述第三时间段的第四时间段内降解。
82.如权利要求79所述的复合材料，还包括与所述第一和第二组柔性纤索编织或缝编在一起的第三组柔性纤丝，形成第二基质。
83.如权利要求73所述的复合材料，其特征在于，用粘合剂将所述基质材料与纤索粘结。
84.如权利要求73所述的复合材料，所述纤索具有粗糙有凹痕、有槽或隆起的外表面。
85.如权利要求73所述的复合材料，所述基质材料通过机械互锁结合方式与所述纤索接触。
86.如权利要求73所述的复合材料，其特征在于，所述纤索具有经过处理的外表面，以促进所述基质的粘附。
CNA2004800408585A 2003-12-18 2004-12-01 设计的脊柱植入物复合材料降解 Pending CN1917909A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/740,055 2003-12-18
US10/740,055 US20050136764A1 (en) 2003-12-18 2003-12-18 Designed composite degradation for spinal implants

Publications (1)

Publication Number Publication Date
CN1917909A true CN1917909A (zh) 2007-02-21

Family

ID=34677779

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2004800408585A Pending CN1917909A (zh) 2003-12-18 2004-12-01 设计的脊柱植入物复合材料降解

Country Status (8)

Country Link
US (1) US20050136764A1 (zh)
EP (2) EP1699499A1 (zh)
JP (1) JP2007514507A (zh)
KR (1) KR20070008545A (zh)
CN (1) CN1917909A (zh)
AU (1) AU2004308898A1 (zh)
CA (1) CA2550329A1 (zh)
WO (1) WO2005063317A1 (zh)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101778645A (zh) * 2007-07-05 2010-07-14 Ucl商业有限公司 生产具有可变刚性的生物材料的方法
CN102316815A (zh) * 2006-03-02 2012-01-11 华沙整形外科股份有限公司 特征为硬度可随时间改变的脊柱棒
CN111110399A (zh) * 2019-12-09 2020-05-08 先健科技(深圳)有限公司 植入式器械
WO2021196163A1 (zh) * 2020-04-03 2021-10-07 董谢平 一种可从刚性固定渐变为非刚性固定的椎弓根钉棒系统
CN113543691A (zh) * 2019-03-08 2021-10-22 纽韦弗医疗设备公司 用于能量递送的系统和方法

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2527778C (en) 2003-06-13 2011-11-08 Tyco Healthcare Group Lp Multiple member interconnect for surgical instrument and absorbable screw fastener
GB0329654D0 (en) 2003-12-23 2004-01-28 Smith & Nephew Tunable segmented polyacetal
US10478179B2 (en) * 2004-04-27 2019-11-19 Covidien Lp Absorbable fastener for hernia mesh fixation
US8114099B2 (en) * 2004-04-27 2012-02-14 Tyco Healthcare Group Lp Absorbable anchor for hernia mesh fixation
US7828830B2 (en) * 2005-05-12 2010-11-09 Lanx, Inc. Dynamic spinal stabilization
CZ299109B6 (cs) * 2005-11-07 2008-04-23 Ústav struktury a mechaniky hornin AV CR, v.v.i. Kostní náhrady a výplne na bázi kompozitních materiálu a zpusob jejich prípravy
US20070191841A1 (en) * 2006-01-27 2007-08-16 Sdgi Holdings, Inc. Spinal rods having different flexural rigidities about different axes and methods of use
US7563274B2 (en) * 2006-04-25 2009-07-21 Warsaw Orthopedic, Inc. Surgical instruments and techniques for controlling spinal motion segments with positioning of spinal stabilization elements
FI119177B (fi) * 2006-05-05 2008-08-29 Bioretec Oy Bioabsorboituva, muotoutuva fiksaatiomateriaali ja -implantti
US7951200B2 (en) * 2006-07-12 2011-05-31 Warsaw Orthopedic, Inc. Vertebral implant including preformed osteoconductive insert and methods of forming
US8298264B2 (en) * 2006-09-07 2012-10-30 Warsaw Orthopedic, Inc Systems and methods for use in spinal support
WO2008067531A2 (en) 2006-11-30 2008-06-05 Smith & Nephew, Inc. Fiber reinforced composite material
JP5416090B2 (ja) 2007-04-18 2014-02-12 スミス アンド ネフュー ピーエルシー 形状記憶ポリマーの膨張成形
AU2008242737B2 (en) 2007-04-19 2013-09-26 Smith & Nephew, Inc. Multi-modal shape memory polymers
US9770534B2 (en) 2007-04-19 2017-09-26 Smith & Nephew, Inc. Graft fixation
GB0715376D0 (en) * 2007-08-07 2007-09-19 Smith & Nephew Coating
EP2200672B1 (en) 2007-09-11 2012-06-27 Solvay Specialty Polymers USA, LLC. Improved prosthetic devices
PL2205185T3 (pl) 2007-10-30 2014-12-31 Woodwelding Ag Urządzenie do wytwarzania zakotwiczenia w tkance ludzkiej lub zwierzęcej
EP2298199B1 (en) * 2008-05-06 2012-05-23 Biedermann Technologies GmbH & Co. KG Rod-shaped implant, in particular for the dynamic stabilization of the spine
WO2010025386A1 (en) * 2008-08-29 2010-03-04 Smed-Ta/Td, Llc Orthopaedic implant
FI20095084A0 (fi) 2009-01-30 2009-01-30 Pekka Vallittu Komposiitti ja sen käyttö
EP2432426B1 (en) * 2009-05-22 2017-05-31 Biorez, Inc. Mechanically competent scaffold for ligament and tendon regeneration
US8888828B2 (en) * 2009-07-16 2014-11-18 Covidien Lp Composite fixation device
US20130172994A1 (en) * 2010-06-03 2013-07-04 Hilton Becker Supporting and forming transitional material for use in supporting prosthesis devices, implants and to provide structure in a human body
US9320601B2 (en) 2011-10-20 2016-04-26 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants
US20120101593A1 (en) 2010-10-20 2012-04-26 BIOS2 Medical, Inc. Implantable polymer for bone and vascular lesions
US11291483B2 (en) 2010-10-20 2022-04-05 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants
US11058796B2 (en) 2010-10-20 2021-07-13 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
WO2015095745A1 (en) 2010-10-20 2015-06-25 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US11207109B2 (en) 2010-10-20 2021-12-28 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US11484627B2 (en) 2010-10-20 2022-11-01 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US10525169B2 (en) 2010-10-20 2020-01-07 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
CN107252343B (zh) * 2012-08-23 2020-11-17 新特斯有限责任公司 骨固定系统
EP2887893B1 (en) * 2012-08-23 2017-08-09 Synthes GmbH Intramedullary fixation system
US9452005B2 (en) 2012-08-23 2016-09-27 DePuy Synthes Products, Inc. Bone fixation system
US10004603B2 (en) 2012-08-23 2018-06-26 DePuy Synthes Products, Inc. Bone implant
US10010609B2 (en) 2013-05-23 2018-07-03 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants
US9408636B2 (en) * 2014-01-27 2016-08-09 Luke Lu Bone connection material
US9370381B2 (en) * 2014-01-27 2016-06-21 Luke Lu Bone connection material
EP2898906B1 (en) * 2014-01-28 2019-11-13 Luke Lu Bone connection material
US10130358B2 (en) 2015-10-07 2018-11-20 Arthrex, Inc. Devices for controlling the unloading of superelastic and shape memory orthopedic implants
EP3416593B1 (en) 2016-02-16 2024-04-03 Children's Medical Center Corporation Autonomously growing implantable device
US11458021B2 (en) * 2016-04-07 2022-10-04 Kambiz Behzadi Anisotropic materials in medical devices
US11219469B2 (en) * 2018-12-03 2022-01-11 Warsaw Orthopedic, Inc. Bone screw and method of manufacture
US11426223B2 (en) * 2019-02-22 2022-08-30 Warsaw Orthopedic, Inc. Bone screw and method of manufacture
KR102070247B1 (ko) * 2019-08-16 2020-01-28 이동오 발목 인대 고정기구
JP7432538B2 (ja) 2021-01-05 2024-02-16 グローブライド株式会社 脊椎固定具用ロッド及びこれを備える脊椎用固定具
JP7432541B2 (ja) 2021-01-25 2024-02-16 グローブライド株式会社 脊椎固定具用ロッド及びこれを備える脊椎用固定具

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2987062A (en) * 1956-07-23 1961-06-06 Arthur E Ellison Bone splint with absorbable section
US3463158A (en) * 1963-10-31 1969-08-26 American Cyanamid Co Polyglycolic acid prosthetic devices
AT261800B (de) * 1966-08-22 1968-05-10 Braun Internat Gmbh B Verfahren zur Herstellung von röhrenförmigen, glatten bzw. mit einem Gewinde versehenen Gewebe-Blutgefäß-Prothesen
FR2439003A1 (fr) * 1978-10-20 1980-05-16 Anvar Nouvelles pieces d'osteosynthese, leur preparation et leur application
US4512038A (en) * 1979-04-27 1985-04-23 University Of Medicine And Dentistry Of New Jersey Bio-absorbable composite tissue scaffold
US4338926A (en) * 1980-11-21 1982-07-13 Howmedica, Inc. Bone fracture prosthesis with controlled stiffness
US4388926A (en) * 1980-12-22 1983-06-21 Ethicon, Inc. High compliance monofilament surgical sutures comprising poly[alkylene terephthalate-co-(2-alkenyl or alkyl)succinate]
US4550449A (en) * 1982-11-08 1985-11-05 Johnson & Johnson Products Inc. Absorbable bone fixation device
US4539981A (en) * 1982-11-08 1985-09-10 Johnson & Johnson Products, Inc. Absorbable bone fixation device
FI69402C (fi) * 1983-09-20 1986-02-10 Materials Consultants Oy Osteosyntesanordning
GB8400932D0 (en) * 1984-01-13 1984-02-15 Geistlich Soehne Ag Bone fracture fixation plates
NL8402178A (nl) * 1984-07-10 1986-02-03 Rijksuniversiteit Entstuk, geschikt voor behandeling door reconstructieve chirurgie van beschadigingen van beenachtig materiaal.
FI75493C (fi) * 1985-05-08 1988-07-11 Materials Consultants Oy Sjaelvarmerat absorberbart osteosyntesmedel.
US5013315A (en) * 1985-07-12 1991-05-07 Minnesota Mining And Manufacturing Company Semiabsorbable bone plate spacer
US4781183A (en) * 1986-08-27 1988-11-01 American Cyanamid Company Surgical prosthesis
US4905680A (en) * 1986-10-27 1990-03-06 Johnson & Johnson Orthopaedics, Inc. Absorbable bone plate
US4756307A (en) * 1987-02-09 1988-07-12 Zimmer, Inc. Nail device
US5057111A (en) * 1987-11-04 1991-10-15 Park Joon B Non-stress-shielding bone fracture healing device
US5092884A (en) * 1988-03-24 1992-03-03 American Cyanamid Company Surgical composite structure having absorbable and nonabsorbable components
US5108755A (en) * 1989-04-27 1992-04-28 Sri International Biodegradable composites for internal medical use
US4990158A (en) * 1989-05-10 1991-02-05 United States Surgical Corporation Synthetic semiabsorbable tubular prosthesis
US5261911A (en) * 1991-06-18 1993-11-16 Allen Carl Anterolateral spinal fixation system
EP0523926A3 (en) * 1991-07-15 1993-12-01 Smith & Nephew Richards Inc Prosthetic implants with bioabsorbable coating
US5571193A (en) * 1992-03-12 1996-11-05 Kampner; Stanley L. Implant with reinforced resorbable stem
US5779706A (en) * 1992-06-15 1998-07-14 Medicon Eg Surgical system
ES2142340T3 (es) * 1993-08-30 2000-04-16 Sulzer Orthopadie Ag Elemento para aumentar temporalmente la rigidez de una protesis.
US5653760A (en) * 1993-08-30 1997-08-05 Saffran; Bruce N. Method and apparatus for managing macromolecular distribution
US5514137A (en) * 1993-12-06 1996-05-07 Coutts; Richard D. Fixation of orthopedic devices
US5626611A (en) * 1994-02-10 1997-05-06 United States Surgical Corporation Composite bioabsorbable materials and surgical articles made therefrom
DE4414675C1 (de) * 1994-04-27 1995-09-28 Kirsch Axel Abdeckeinrichtung für Knochendefektstellen und Verfahren zu deren Herstellung
ATE310839T1 (de) * 1994-04-29 2005-12-15 Scimed Life Systems Inc Stent mit kollagen
US5591169A (en) * 1994-06-14 1997-01-07 Benoist; Louis Device and method for positioning and holding bone fragments in place
EP0692227A1 (de) * 1994-07-11 1996-01-17 SULZER Medizinaltechnik AG Flächiges Implantat
US5676976A (en) 1995-05-19 1997-10-14 Etex Corporation Synthesis of reactive amorphous calcium phosphates
US6027742A (en) * 1995-05-19 2000-02-22 Etex Corporation Bioresorbable ceramic composites
AU723740B2 (en) 1995-06-06 2000-09-07 Howmedica Inc. Biocompatible hydroxyapatite formulations and uses therefor
US5783217A (en) 1995-11-07 1998-07-21 Etex Corporation Low temperature calcium phosphate apatite and a method of its manufacture
US5902599A (en) * 1996-02-20 1999-05-11 Massachusetts Institute Of Technology Biodegradable polymer networks for use in orthopedic and dental applications
US5935172A (en) * 1996-06-28 1999-08-10 Johnson & Johnson Professional, Inc. Prosthesis with variable fit and strain distribution
US5725591A (en) * 1996-08-13 1998-03-10 Johnson & Johnson Professional, Inc. Acetabular bearing system
CA2270185C (en) 1996-10-16 2009-01-06 Etex Corporation Method of preparing a poorly crystalline calcium phosphate and methods of its use
JP4260891B2 (ja) 1996-10-16 2009-04-30 エテックス コーポレイション 生体セラミック組成物
US6004323A (en) * 1997-02-04 1999-12-21 The University Of Iowa Research Foundation Surgically implantable fastening system
AU6081298A (en) 1997-03-07 1998-09-29 Bertram Burian Braking device
AU6493598A (en) * 1997-04-16 1998-11-11 White Spot Ag Biodegradable osteosynthesis implant
US6017366A (en) * 1997-04-18 2000-01-25 W. L. Gore & Associates, Inc. Resorbable interposition arthroplasty implant
US6045579A (en) * 1997-05-01 2000-04-04 Spinal Concepts, Inc. Adjustable height fusion device
JP4302877B2 (ja) 1997-07-30 2009-07-29 エモリー・ユニバーシテイ 新規な骨鉱化蛋白質、ｄｎａ、ベクター及び発現系
US6241771B1 (en) * 1997-08-13 2001-06-05 Cambridge Scientific, Inc. Resorbable interbody spinal fusion devices
US5935127A (en) * 1997-12-17 1999-08-10 Biomet, Inc. Apparatus and method for treatment of a fracture in a long bone
JPH11206871A (ja) * 1998-01-27 1999-08-03 Bmg:Kk 生体内分解吸収性の骨固定材およびその製造方法
US6160084A (en) * 1998-02-23 2000-12-12 Massachusetts Institute Of Technology Biodegradable shape memory polymers
US6019792A (en) * 1998-04-23 2000-02-01 Cauthen Research Group, Inc. Articulating spinal implant
CA2329363C (en) * 1998-04-23 2007-12-11 Cauthen Research Group, Inc. Articulating spinal implant
US5993452A (en) * 1998-08-24 1999-11-30 Biomet Inc. Cerclage system
US6409764B1 (en) * 1998-12-03 2002-06-25 Charles F. White Methods and articles for regenerating bone or peridontal tissue
US6206883B1 (en) * 1999-03-05 2001-03-27 Stryker Technologies Corporation Bioabsorbable materials and medical devices made therefrom
US6187008B1 (en) * 1999-07-07 2001-02-13 Bristol-Myers Squibb Device for temporarily fixing bones
WO2001008594A1 (en) * 1999-07-28 2001-02-08 C.R. Bard, Inc. Hernia prosthesis
US6540746B1 (en) * 1999-09-30 2003-04-01 Sulzer Orthopedics Ltd. Bone plate for splinting a fracture at a bone with a plurality of bone screws
US6293949B1 (en) * 2000-03-01 2001-09-25 Sdgi Holdings, Inc. Superelastic spinal stabilization system and method
US6638312B2 (en) * 2000-08-04 2003-10-28 Depuy Orthopaedics, Inc. Reinforced small intestinal submucosa (SIS)
US6605090B1 (en) * 2000-10-25 2003-08-12 Sdgi Holdings, Inc. Non-metallic implant devices and intra-operative methods for assembly and fixation
JP4302515B2 (ja) * 2001-07-16 2009-07-29 デピュイ・プロダクツ・インコーポレイテッド 単体型外科装置および方法
JP4197158B2 (ja) * 2001-07-16 2008-12-17 デピュイ・プロダクツ・インコーポレイテッド 天然に発生する生物学的に誘導されている材料による装置
US6902932B2 (en) * 2001-11-16 2005-06-07 Tissue Regeneration, Inc. Helically organized silk fibroin fiber bundles for matrices in tissue engineering
EP1539044B1 (en) * 2002-07-17 2011-04-06 Proxy Biomedical Limited Film for medical Implantation
US20060106419A1 (en) * 2002-08-23 2006-05-18 Peter Gingras Three dimensional implant
US20050085814A1 (en) 2003-10-21 2005-04-21 Sherman Michael C. Dynamizable orthopedic implants and their use in treating bone defects

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102316815A (zh) * 2006-03-02 2012-01-11 华沙整形外科股份有限公司 特征为硬度可随时间改变的脊柱棒
CN101778645A (zh) * 2007-07-05 2010-07-14 Ucl商业有限公司 生产具有可变刚性的生物材料的方法
CN101778645B (zh) * 2007-07-05 2013-04-17 Ucl商业有限公司 生产具有可变刚性的生物材料的方法
CN113543691A (zh) * 2019-03-08 2021-10-22 纽韦弗医疗设备公司 用于能量递送的系统和方法
CN113543691B (zh) * 2019-03-08 2024-02-13 纽韦弗医疗设备公司 用于能量递送的系统和方法
CN111110399A (zh) * 2019-12-09 2020-05-08 先健科技(深圳)有限公司 植入式器械
CN111110399B (zh) * 2019-12-09 2021-12-03 先健科技(深圳)有限公司 植入式器械
WO2021196163A1 (zh) * 2020-04-03 2021-10-07 董谢平 一种可从刚性固定渐变为非刚性固定的椎弓根钉棒系统

Also Published As

Publication number Publication date
AU2004308898A1 (en) 2005-07-14
US20050136764A1 (en) 2005-06-23
EP1952829A3 (en) 2008-12-03
CA2550329A1 (en) 2005-07-14
EP1952829A2 (en) 2008-08-06
EP1699499A1 (en) 2006-09-13
KR20070008545A (ko) 2007-01-17
JP2007514507A (ja) 2007-06-07
WO2005063317A1 (en) 2005-07-14

Similar Documents

Publication Publication Date Title
CN1917909A (zh) 设计的脊柱植入物复合材料降解
US9730740B2 (en) Fracture fixation systems
JP2740531B2 (ja) プレストレス（ｐｒｅｓｔｒｅｓｓ）を加えた外科用網状物
CN1901842A (zh) 动态矫形植入物及其在治疗骨缺陷中的使用
CN1849099A (zh) 用于脊柱固定的由形状记忆聚合材料形成的植入物
WO2007076272A2 (en) Bone graft composition, method and implant
WO2022241150A2 (en) Degradable composite and method of fabrication
AU751967B2 (en) Implant for implantation in humans or animals comprising flexible, thread-shaped elements
US20130195955A1 (en) Implants Containing BMP-7
WO2022246122A1 (en) Degradable composite and method of fabrication
FI129657B (en) Fiber-reinforced composite device, where continuous fibers have been arranged in functional order, for the treatment and management of musculoskeletal and dental diseases
CN110167606A (zh) 用于治疗骨缺陷的植入物和套件
WO2022104114A1 (en) Elongated composite for an implant
WO2011075803A1 (pt) Processo, produção, compósitos, sistema e dispositivos médico-veterinários bio-ativos, biointegráveis, condutores, indutores teciduais para fixação, reparo, reconstrução, remodelação, plastias intra, supra teciduais e/ou totais, permanentes, biológica e fisiologicamente biocompatíveis
WO2023225649A1 (en) Degradable composite and method of fabrication
EP4341329A1 (en) Degradable composite and method of fabrication
EP4337720A2 (en) Degradable composite and method of fabrication
WO2023220730A1 (en) Degradable composite and method of fabrication
Glatt Influence of the mechanical environment upon the healing of segmental bone defects in the rat femur

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication