CN1911279A - Acupuncture point plaster for preventing and treating bronchitic asthma and its prepn. method - Google Patents
Acupuncture point plaster for preventing and treating bronchitic asthma and its prepn. method Download PDFInfo
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- CN1911279A CN1911279A CNA2006100200395A CN200610020039A CN1911279A CN 1911279 A CN1911279 A CN 1911279A CN A2006100200395 A CNA2006100200395 A CN A2006100200395A CN 200610020039 A CN200610020039 A CN 200610020039A CN 1911279 A CN1911279 A CN 1911279A
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- zingiberis recens
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Abstract
A Chinese medicine in the form of acupoint paster for preventing and treating bronchial asthma is prepared from asarum herb, Kan-sui root, corydalis tuber and white mustard seed. Its preparing process is also disclosed.
Description
Technical field
The invention belongs to the medicine of treatment bronchial asthma, be specifically related to a kind of bronchial asthma point application that prevents and treats.
Background technology
In recent years, follow motherland's medical science " inner disease outer treat; reach the same goal by different routes " and reach " the too late person that external treatment can be mended treatment by oral administration of medicines ", " take stopgap measures when sending out; effect a permanent cure at ordinary times ", Therapeutic Principle such as " treating winter disease in summer ", the treatment that has increasing external treatment with Chinese medicine therapy to be applied to primary disease has all obtained curative effect preferably, especially Chinese medicine point application, but the time of at every turn applying ointment or plaster is longer, weak point person 4～6 hours, elder 24 hours, adopt Semen Sinapis Albae as Zuo Shi, give birth to Radix Kansui, Herba Asari, medicament plasters such as Ramulus Cinnamomi treatment in 24 hours asthma, and weather sweltering heat in dog days, the overlong time of applying ointment or plaster is made troubles to the patient.
Summary of the invention
The object of the present invention is to provide a kind of time of applying ointment or plaster short prevent and treat bronchial asthma point application and preparation method thereof, to address the above problem.
One of technical scheme of the present invention is: prevent and treat bronchial asthma point application, its raw material comprises Herba Asari, Radix Kansui, corydalis tuber and Semen Sinapis Albae, and weight ratio is: 2: 1～6: 1～6: 1～6, and it also comprises the solvent carrier Rhizoma Zingiberis Recens juice.
Two of technical scheme of the present invention is: prevent and treat bronchial asthma point application preparation method, Herba Asari, Radix Kansui, corydalis tuber are pressed corresponding proportional sampling, place the moderate heat bake and parch to buff, cool off under the room temperature, again the Semen Sinapis Albae of respective amount is fried in moderate heat to yellowish, cooling back and Herba Asari, Radix Kansui, corydalis tuber mix homogeneously, it is standby that grinding is powder; Modulate above-mentioned medicated powder to pasty state with Rhizoma Zingiberis Recens juice, pastel is evenly placed on the paster; Described Herba Asari, Radix Kansui, corydalis tuber and Semen Sinapis Albae, weight ratio is: 2: 1～6: 1～6: 1～6.
The weight ratio of described Herba Asari, Radix Kansui, corydalis tuber and Semen Sinapis Albae is any ratio in its ratio range;
Described Rhizoma Zingiberis Recens juice is raw juice of ginger or raw juice of ginger water diluent.
The volume ratio of described raw juice of ginger water diluent is: raw juice of ginger: water=1: 10～30.
The bulking value ratio of described Herba Asari, Radix Kansui, corydalis tuber and Semen Sinapis Albae raw material summation and Rhizoma Zingiberis Recens juice is: 100: 20～150, and bulking value unit is gram: milliliter.
This medication of applying ointment or plaster is few, and the time of applying ointment or plaster is short, and drug effect is obvious, and when dog days, weather was hot, the short time applied ointment or plaster general 1～2 hour, and it is greatly convenient to bring to the patient, has solved the long-time usefulness of pasting in the existing summer of applying ointment or plaster, to the influence of skin; Its preparation method is simple, and is easy to control.
The specific embodiment
Embodiment 1
Prescription: Herba Asari 4 grams, Radix Kansui 2 grams, corydalis tuber 2 grams and Semen Sinapis Albae 2 grams, Rhizoma Zingiberis Recens was pricked juice, by 1: 10 parts by volume adding distil water mixing for standby use.
Preparation: Herba Asari, Radix Kansui, corydalis tuber are pressed corresponding proportional sampling, place the moderate heat bake and parch to buff, cool off under the room temperature, again the Semen Sinapis Albae of respective amount is fried in moderate heat to yellowish, cooling back and Herba Asari, Radix Kansui, corydalis tuber mix homogeneously, it is standby that grinding is powder; The medicated powder hybrid modulation of getting 5 milliliters of Rhizoma Zingiberis Recens juice and 10 grams evenly place pastel on the paster to pasty state, diameter 1～2cm.
Embodiment 2
Prescription: Herba Asari 4 grams, Radix Kansui 3 grams, corydalis tuber 4 grams and Semen Sinapis Albae 2 grams, Rhizoma Zingiberis Recens was pricked juice, by 1: 15 parts by volume adding distil water mixing for standby use.
Preparation: it is standby to prepare the medicated powder end as stated above; The medicated powder hybrid modulation of getting 8 milliliters of Rhizoma Zingiberis Recens juice and 10 grams evenly place pastel on the paster to pasty state, diameter 1～2cm.
Embodiment 3
Prescription: Herba Asari 4 grams, Radix Kansui 4 grams, corydalis tuber 3 grams and Semen Sinapis Albae 4 grams, Rhizoma Zingiberis Recens was pricked juice, by 1: 15 parts by volume adding distil water mixing for standby use.
Preparation: it is standby to prepare the medicated powder end as stated above; The medicated powder hybrid modulation of getting 10 milliliters of Rhizoma Zingiberis Recens juice and 10 grams evenly place pastel on the paster to pasty state, diameter 1～2cm.
Embodiment 4
Prescription: Herba Asari 4 grams, Radix Kansui 6 grams, corydalis tuber 2 grams and Semen Sinapis Albae 5 grams, Rhizoma Zingiberis Recens was pricked juice, by 1: 20 parts by volume adding distil water mixing for standby use.
Preparation: it is standby to prepare the medicated powder end as stated above; The medicated powder hybrid modulation of getting 10 milliliters of Rhizoma Zingiberis Recens juice and 10 grams evenly place pastel on the paster to pasty state, diameter 1～2cm.
Embodiment 5
Prescription: Herba Asari 4 grams, Radix Kansui 6 grams, corydalis tuber 6 grams and Semen Sinapis Albae 6 grams, Rhizoma Zingiberis Recens was pricked juice, by 1: 25 parts by volume adding distil water mixing for standby use.
Preparation: it is standby to prepare the medicated powder end as stated above; The medicated powder hybrid modulation of getting 15 milliliters of Rhizoma Zingiberis Recens juice and 10 grams evenly place pastel on the paster to pasty state, diameter 1～2cm.
Embodiment 6
Prescription: Herba Asari 4 grams, Radix Kansui 5 grams, corydalis tuber 6 grams and Semen Sinapis Albae 3 grams, Rhizoma Zingiberis Recens was pricked juice, by 1: 30 parts by volume adding distil water mixing for standby use.
Preparation: it is standby to prepare the medicated powder end as stated above; The medicated powder hybrid modulation of getting 5 milliliters of Rhizoma Zingiberis Recens juice and 10 grams evenly place pastel on the paster to pasty state, diameter 1～2cm.
Embodiment 7
Prescription: Herba Asari 4 grams, Radix Kansui 8 grams, corydalis tuber 7 grams and Semen Sinapis Albae 10 grams, Rhizoma Zingiberis Recens was pricked juice, by 1: 18 parts by volume adding distil water mixing for standby use.
Preparation: it is standby to prepare the medicated powder end as stated above; The medicated powder hybrid modulation of getting 8 milliliters of Rhizoma Zingiberis Recens juice and 10 grams evenly place pastel on the paster to pasty state, diameter 1～2cm.
Embodiment 8
Prescription: Herba Asari 4 grams, Radix Kansui 12 grams, corydalis tuber 2 grams and Semen Sinapis Albae 8 grams, Rhizoma Zingiberis Recens was pricked juice, by 1: 28 parts by volume adding distil water mixing for standby use.
Preparation: it is standby to prepare the medicated powder end as stated above; The medicated powder hybrid modulation of getting 10 milliliters of Rhizoma Zingiberis Recens juice and 10 grams evenly place pastel on the paster to pasty state, diameter 1～2cm.
Embodiment 9
Prescription: Herba Asari 4 grams, Radix Kansui 12 grams, corydalis tuber 12 grams and Semen Sinapis Albae 12 grams, Rhizoma Zingiberis Recens was pricked juice, by 1: 27 parts by volume adding distil water mixing for standby use.
Preparation: it is standby to prepare the medicated powder end as stated above; The medicated powder hybrid modulation of getting 12 milliliters of Rhizoma Zingiberis Recens juice and 10 grams evenly place pastel on the paster to pasty state, diameter 1～2cm.
Embodiment 10
Prescription: Herba Asari 50 grams, Radix Kansui 100 grams, corydalis tuber 100 grams and Semen Sinapis Albae 100 grams, Rhizoma Zingiberis Recens was pricked juice, by 1: 14 parts by volume adding distil water mixing for standby use.
Preparation: it is standby to prepare the medicated powder end as stated above; The medicated powder hybrid modulation of getting 150 milliliters of Rhizoma Zingiberis Recens juice and 350 grams evenly place pastel on the paster to pasty state, diameter 1～2cm.
When what is the first fu, second of the three ten-day periods of the hot season, dog days annual dog days with medicament plaster in acupuncture points such as Dingchuan (two), fei shu (two), Pishu (two), shen shu (two), Danzhong, Tiantus, (every cave plaster medicine diameter took off (taking off) as if 1～2cm) after applying ointment or plaster 1～2 hour at every turn when the patient has burning hot sense.
Test to above-mentioned:
Animal is provided by male SD rat (being provided by the laboratory animal department of the Chinese Academy of Sciences of Tongji Medical College, Huazhong Science and Technology Univ.), about 4～8 age in week body weight 200 grams, and 20～22 ℃ of raisings of room temperature.Light freely replaced in 12 hours, ad lib, drinking-water.Relative humidity 45%.
Medicine: the present invention applies ointment or plaster;
Setting up bronchial asthma rat model animal model in asthma prepares by literature method: test the 1st day every rats by intraperitoneal injection antigen liquid 1ml (egg protein 100mg, deactivation pertussis vaccine 5 * 10
9, aluminium hydroxide 100mg), CM-1 ultrasonic atomization therapy instrument 1% egg protein of spraying is adopted in 2 week backs (the 15th day), animal is sucked about 20min to dyspnea with rapid and short breath, cough occurring, even fall and wait the respiratory tract spasm to block symptom, and the prompting modeling is successful.Normal group injection and atomizing equal volume normal saline.
Animal grouping is divided into seven groups at random: normal group, model group, the present invention apply ointment or plaster group incubation period, acusector group incubation period, the present invention apply ointment or plaster stage of attack group, acusector stage of attack group, Western medicine group.
Therapeutic Method the present invention's incubation period group, incubation period acusector group of applying ointment or plaster: bring out back (promptly testing the 16th day) beginning treatment 3 days continuously, bring out once more promptly to test and brought out in the 19th day, (tested the 20th day) then and treated continuously again 3 days, the rest may be inferred treated 15 days altogether.Application operation of the present invention: choose bilateral Dingchuan, fei shu, SHENYU acupoint with reference to " laboratory animal acupuncture point collection of illustrative plates " that nation of Huaxing works out, cut off the hair of its corresponding site, make its skin expose, diameter 1～2cm size plaster medicine of the present invention placed be affixed on corresponding acupuncture point on the white adhesive plaster, every day 1 time, each about 2 hours, promptly to erubescence, remove medicine.Incubation period, acusector group acupoint selection was identical with the present invention's incubation period group of applying ointment or plaster, and the acupuncture needle acupuncture with 0.5 cun connects the G6805 electric needle therapeutic instrument, adopts dilatational wave, and frequency is 100 times/min, treats 30min, every day 1 time.
Stage of attack the present invention's group, stage of attack acusector group of applying ointment or plaster: treat immediately after bringing out, acupoint selection, Therapeutic Method are identical with apply ointment or plaster group, incubation period acusector group of the present invention's incubation period respectively.
Western medicine group: adopt the spraying of beclometasone propellant, with other group synchronous therapeutics.
Model group: without any treatment.
Experimental result such as following table
1, to the influence of cell number and classification thereof in the bronchus asthma model rat bronchoalveolar lavage fluid
Each organizes cell counting in the bronchoalveolar lavage fluid and classification (x ± s)
| Group | Total cell number (10 6/ml) | Macrophage (%) | Oxyphil cell (%) | Neutrophil cell (%) | Lymphocyte (%) |
| Normal group | 4.42±0.16 | 82.57±12.32 | 4.58±1.79 | 7.33±2.34 | 5.07±1.95 |
| Model group | 9.52±0.58 * | 3.20±7.88 * | 18.43±4.37 ** | 5.60±2.08 | 1.91±0.49 |
| The present invention applies ointment or plaster and organizes incubation period | 6.14±3.64 △ | 74.41±5.67 ▲ | 9.26±2.91 △△ | 5.20±2.02 | 10.37±4.89 |
| Acusector group incubation period | 8.69±3.29 ▲# | 74.12±5.23 ▲ | 13.16±2.24 △# | 3.44±1.87 | 8052±3.54 |
| The present invention's stage of attack group of applying ointment or plaster | 9.45±2.55 ▲# | 72.86±2.83 ▲ | 14.37±2.79 △# | 5.20±1.98 | 7.61±1.49 |
| Acusector stage of attack group | 9.20±2.58 ▲# | 73.39±3.89 ▲ | 14.77±2.39 △# | 4.76±1.28 | 6.48±1.19 |
| The Western medicine group | 9.03±2.61 ▲# | 75.50±2.38 ▲ | 11.67±2.04 △# | 4.73±1.68 | 7.60±1.31 |
Annotate: compare with normal group
*P＜0.05,
*P＜0.01; Compare with model group ▲ P＞0.05, △ P＜0.05, △ △ P＜0.01; With the present invention relatively #P＜0.05 of incubation period group of applying ointment or plaster.
2, to the influence of bronchus asthma model rat blood serum IgE
Table SERUM IgE content (x ± s)
| Group | IgE |
| Normal group | 15.76±3.19 |
| Model group | 108.31±6.18 ** |
| The present invention applies ointment or plaster and organizes incubation period | 23.08±6.40 *△ |
| Acusector group incubation period | 35.14±5.33 **△▲▲ |
| The present invention's stage of attack group of applying ointment or plaster | 31.22±4.87 △▲ |
| Acusector stage of attack group | 35.29±5.17 △▲▲ |
| The Western medicine group | 36.08±5.60 △▲▲ |
Annotate: compare with normal group:
*P＜0.05,
*P＜0.01; Compare with model group: △ P＜0.01; Apply ointment or plaster incubation period group relatively with the present invention: ▲ P＜0.05, ▲ ▲ P＜0.01;
3, to the influence of bronchus asthma model lung tissue of rats IL-6
IL-6 content in the table lung tissue (x ± s)
| Group | IL-6 |
| Normal group | 56.88±4.57 |
| Model group | 131.11±4.62 * |
| The present invention applies ointment or plaster and organizes incubation period | 93.51±4.89 *△ |
| Acusector group incubation period | 107.08±4.07 *△▲ |
| The present invention's stage of attack group of applying ointment or plaster | 113.63±5.18 *△▲ |
| Acusector stage of attack group | 113.48±5.13 *△▲ |
| The Western medicine group | 92.96±4.03 *△ |
Annotate: compare with normal group:
*P＜0.01; Compare with model group: △ P＜0.01; Apply ointment or plaster incubation period group relatively with the present invention: ▲ P＜0.01;
4, to the influence of the β-END of bronchus asthma model rat cerebral tissue, IL-1
| Table is respectively organized relatively (x ± s) of β-END in the rat brain, IL-1 The positive expression rate | ||
| Group | β-END | IL-1 |
| Normal group | 9.01±2.37 | 1.15±0.61 |
| Model group | 12.57±2.86 △ | 2.03±0.77 △ |
| The present invention applies ointment or plaster and organizes incubation period | 33.88±6.08 ▲ | 4.89±0.92 ▲ |
| Acusector group incubation period | 29.15±5.25 ▲* | 3.15±0.89 ▲** |
| The present invention's stage of attack group of applying ointment or plaster | 30.46±6.15 ▲ | 3.52±0.96 ▲** |
| Acusector stage of attack group | 29.87±5.05 ▲ | 3.24±1.01 ▲** |
| The Western medicine group | 12.40±2.45 ** | 2.07±0.89 |
Annotate: compare with normal group: △ P＜0.01; Compare with model group: ▲ P＜0.01; Compare with apply ointment or plaster incubation period group of the present invention:
*P＜0.05,
*P＜0.01
Experimental result shows:
Apply ointment or plaster in the present invention and to prevent and treat in the experiment of bronchus asthma model rat, finding that the present invention applies ointment or plaster can significantly reduce quantity, the especially oxyphil cell of inflammatory cell in the bronchoalveolar lavage fluid, illustrates that this therapy can obviously improve respiratory tract inflammatory symptom.The asthmatic model group is visible thin, a large amount of inflammatory cell infiltrations are arranged around bronchia wall and the accompanying artery, and bronchial mucosa wrinkle wall increases, prolongs, and smooth muscle thickens, and the goblet cell hypertrophy is obvious, and secretions gathers, and the part alveolar ectasia loses normal configuration; The present invention applies ointment or plaster and organizes visible part bronchial wall and the gathering of periangiitis sexual cell incubation period, the alveolar part is slightly expanded, bronchial wall goblet cell hypertrophy is not obvious, show that this therapy can obviously improve the degree of its asthma attack, alleviate the lung tissue local inflammation and ooze out and inflammatory infiltration.SERUM IgE can mediate and cause the allergy inflammatory effect, brings into play its biological action by high-affinity receptor, plays an important role in asthma morbidity, and experiment shows that the present invention applies ointment or plaster and can reduce the SERUM IgE that increases unusually, can slow down allergy.The cytokine that most have extensive biologic activity of IL-6 for finding at present can promote the synthetic of IgE, participates in the morbidity of bronchial asthma, and experimental result shows that the present invention applies ointment or plaster and can reduce its content, illustrates that the preventive and therapeutic effect that the present invention applies ointment or plaster may be relevant therewith.β-END, IL-1 play an important role to immunomodulating in the brain, IL-1 is the class important medium in the nerve immunity regulating loop, experiment finds that the present invention's incubation period group positive cell of applying ointment or plaster distributes comparatively intensive, comparing with model group has highly significant difference, and β-END, the IL-1 that prompting has a neuroimmunomodulation may participate in the central mechanism of the present invention's effect of applying ointment or plaster.This shows that the present invention applies ointment or plaster and prevents and treats bronchial asthma and mainly realize by regulating its immune function, promptly regulates the amount of periphery SERUM IgE, IL-6 and maincenter β-END, IL-1.
Claims (8)
1, a kind ofly prevent and treat bronchial asthma point application, its raw material comprises Herba Asari, Radix Kansui, corydalis tuber and Semen Sinapis Albae, and weight ratio is: 2: 1～6: 1～6: 1～6, and it also comprises the solvent carrier Rhizoma Zingiberis Recens juice.
2, prevent and treat bronchial asthma point application according to claim 1, it is characterized in that described Rhizoma Zingiberis Recens juice is raw juice of ginger or raw juice of ginger water diluent.
3, prevent and treat bronchial asthma point application according to claim 1, it is characterized in that the volume ratio of raw juice of ginger water diluent is: raw juice of ginger: water=1: 10～30.
4, as described in claim 1 or 2 or 3, prevent and treat bronchial asthma point application, it is characterized in that the bulking value ratio of four kinds of raw material summations and Rhizoma Zingiberis Recens juice is: 100: 20～150, bulking value unit is gram: milliliter.
5, a kind of bronchial asthma point application preparation method of preventing and treating, Herba Asari, Radix Kansui, corydalis tuber are pressed corresponding proportional sampling, place the moderate heat bake and parch to buff, cool off under the room temperature, again the Semen Sinapis Albae of respective amount is fried in moderate heat to yellowish, cooling back and Herba Asari, Radix Kansui, corydalis tuber mix homogeneously, it is standby that grinding is powder; Modulate above-mentioned medicated powder to pasty state with Rhizoma Zingiberis Recens juice, pastel is evenly placed on the paster; Described Herba Asari, Radix Kansui, corydalis tuber and Semen Sinapis Albae, weight ratio is: 2: 1～6: 1～6: 1～6.
6, as described in claim 5, prevent and treat bronchial asthma point application preparation method, it is characterized in that the bulking value ratio of four kinds of raw material summations and Rhizoma Zingiberis Recens juice is: 100: 20～150, bulking value unit is gram: milliliter.
7, as described in claim 5, prevent and treat bronchial asthma point application preparation method, it is characterized in that described Rhizoma Zingiberis Recens juice is raw juice of ginger or raw juice of ginger water diluent.
8, prevent and treat bronchial asthma point application preparation method as described in claim 5 or 6 or 7, it is characterized in that described Rhizoma Zingiberis Recens juice is the raw juice of ginger water diluent, the volume ratio of raw juice of ginger water diluent is: raw juice of ginger: water=1: 10～30.
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| CNA2006100200395A CN1911279A (en) | 2006-08-24 | 2006-08-24 | Acupuncture point plaster for preventing and treating bronchitic asthma and its prepn. method |
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|---|---|---|---|
| CNA2006100200395A CN1911279A (en) | 2006-08-24 | 2006-08-24 | Acupuncture point plaster for preventing and treating bronchitic asthma and its prepn. method |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102580020A (en) * | 2010-12-01 | 2012-07-18 | 介休市中医医院 | Traditional Chinese medicine composition for curing asthma |
| CN102988646A (en) * | 2013-01-09 | 2013-03-27 | 上海浦东高星生物技术研究所 | Chinese patent drug for treating asthma |
| CN103169754A (en) * | 2011-12-09 | 2013-06-26 | 上海市中医医院 | Traditional Chinese medicinal composition for treating asthma |
| CN105233231A (en) * | 2015-11-17 | 2016-01-13 | 泸州医学院附属中医医院 | Pharmaceutical composition for treating respiratory diseases |
| CN106581178A (en) * | 2016-12-15 | 2017-04-26 | 忠县中医医院 | Dog-days paste for preventing and treating asthma and preparation method of dog-days paste |
| CN107213207A (en) * | 2017-06-12 | 2017-09-29 | 钦州学院 | The plaster and application method of three nine-day periods after the winter solstice point-application |
| CN107669841A (en) * | 2017-11-01 | 2018-02-09 | 吴大斌 | Treat the Chinese medicine composition of cold bronchial astehma |
| CN111012853A (en) * | 2020-01-08 | 2020-04-17 | 河北省中医院 | External plaster for treating asthma and preparation method thereof |
-
2006
- 2006-08-24 CN CNA2006100200395A patent/CN1911279A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102580020A (en) * | 2010-12-01 | 2012-07-18 | 介休市中医医院 | Traditional Chinese medicine composition for curing asthma |
| CN103169754A (en) * | 2011-12-09 | 2013-06-26 | 上海市中医医院 | Traditional Chinese medicinal composition for treating asthma |
| CN103169754B (en) * | 2011-12-09 | 2014-05-07 | 上海市中医医院 | Traditional Chinese medicinal composition for treating asthma |
| CN102988646A (en) * | 2013-01-09 | 2013-03-27 | 上海浦东高星生物技术研究所 | Chinese patent drug for treating asthma |
| CN102988646B (en) * | 2013-01-09 | 2014-05-14 | 上海浦东高星生物技术研究所 | Chinese patent drug for treating asthma |
| CN105233231A (en) * | 2015-11-17 | 2016-01-13 | 泸州医学院附属中医医院 | Pharmaceutical composition for treating respiratory diseases |
| CN106581178A (en) * | 2016-12-15 | 2017-04-26 | 忠县中医医院 | Dog-days paste for preventing and treating asthma and preparation method of dog-days paste |
| CN107213207A (en) * | 2017-06-12 | 2017-09-29 | 钦州学院 | The plaster and application method of three nine-day periods after the winter solstice point-application |
| CN107669841A (en) * | 2017-11-01 | 2018-02-09 | 吴大斌 | Treat the Chinese medicine composition of cold bronchial astehma |
| CN111012853A (en) * | 2020-01-08 | 2020-04-17 | 河北省中医院 | External plaster for treating asthma and preparation method thereof |
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