CN1286492C - Traditional Chinese medicinal plaster - Google Patents
Traditional Chinese medicinal plaster Download PDFInfo
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- CN1286492C CN1286492C CN 200410006205 CN200410006205A CN1286492C CN 1286492 C CN1286492 C CN 1286492C CN 200410006205 CN200410006205 CN 200410006205 CN 200410006205 A CN200410006205 A CN 200410006205A CN 1286492 C CN1286492 C CN 1286492C
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- daphne giraldii
- giraldii nitsche
- extract
- patch
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Abstract
The present invention relates to a traditional Chinese medicinal plaster, particularly to a plaster prepared from the raw material of a traditional Chinese medicine-girald daphne bark. The present invention has certain curative effects on pain and swelling due to rheumatic diseases, and especially has significant curative effects on blood stasis obstruction type arthralgia syndromes and cold wetness obstruction type arthralgia syndromes. The present invention has obvious efficiencies of activating blood circulation to dissipate blood stasis, dredging the meridian passage, dispelling wind, eliminating dampness and alleviating pain.
Description
Technical field:
The present invention relates to a kind of new Chinese medicine preparation, particularly a kind of is the patch of feedstock production with the Chinese medicine Daphne giraldii Nitsche.
Background technology:
Daphne giraldii Nitsche originates in ground such as Shaanxi, is the root bark or the peel of stem of Thymelaeceae plant Daphne Giraldii Nitsche, and distinguish the flavor of little acid, hardship are warm in nature, slightly poisonous.Cure mainly rheumatic arthralgia, numb limbs and tense tendons, traumatic injury, have the effect of expelling wind and removing dampness, pain relieving cold expelling.Daphne giraldii Nitsche has certain curative effect to pain, the swelling of rheumatism, especially obstruction of collaterals by blood stasis type and cold dampness accumulation pattern arthromyodynia is had the obvious treatment effect.This medical instrument has tangible blood circulation promoting and blood stasis dispelling, dredge the meridian passage, expelling wind and removing dampness, analgesic effect.This medicine is applicable to rheumatism pain such as treatment rheumatoid arthritis, osteoarthritis, gout, cervical spondylosis.
In the process that human and disease are done to strive, formed many pharmaceutical dosage forms, wherein commonly used with oral formulations.Because traditional medication ubiquity blood concentration fluctuation, the factors such as Digestive system, food that are subject to when absorbing by digestive tract are disturbed, the part medicine is destroyed shortcomings such as (first pass effects) by liver, so that curative effect reduces, so need frequent medication, dosage is bigger, and some medicine has zest to gastrointestinal mucosa in addition, can produce a series of untoward reaction.So a kind of transdermal patch that is referred to as third generation dosage form has just produced.Patch claims paster again, and its advantage is: 1. can produce lasting, constant local organization drug level, thereby can alleviate untoward reaction; The first pass effect of liver has improved bioavailability of medicament when 2. having avoided oral administration; 3. avoid pain on injection and the bad mouthfeel when oral; 4. but patient's self-medication is easy to use; 5. reduce administration number of times and dosage.Daphne giraldii Nitsche has the effect of " expelling wind and removing dampness, promoting blood circulation and stopping pain ", is used for the treatment of rheumatic, rheumatoid arthritis etc.Consider domestic based on tablet and injection, injection such as long term injections bring bigger misery can for the patient animally and mentally, and tablet needs orally repeatedly also can bring inconvenience to the patient every day, and the similar medicine of this disease of treatment of existing national standard has following several at present:
1. shaolin plaster for rheumatism and wound: function: expelling wind and cold, muscles and tendons relaxing to alleviate pain, removing blood stasis and activating blood flow.
2. dog skin plaster: function: relieving rheumatism and cold, invigorating blood circulation and stopping pains.
3. SHANGSHI ZHITONG GAO: function: wind-damp dispelling, promoting blood circulation and stopping pain.
4. FENGLIAOXING FENGSHI DIEDA YAOJIU: function: expelling wind and removing dampness, promoting blood circulation and stopping pain.
From above-mentioned kind as can be seen, the emphasis that has in the medicine of the treatment primary disease of existing national standard is at present dispeled the wind, is dehumidified, the emphasis cold expelling that has, and the emphasis that has is invigorated blood circulation, and more is to dispel the wind, dehumidify, invigorate blood circulation and take into account.Because these medicines all adopt the conventional process techniques preparation, therefore exist and use inconvenience, drug effect is not good, complicated component, the defective that side effect is many.
In recent years, along with improving constantly of living standards of the people, social competition is more and more fierce, the quickening of rhythm of life.Require easy, quick, eutherapeutic pharmaceutical requirements more and more obvious.The present invention utilizes Daphne giraldii Nitsche to be raw material, utilizes modern technology to make and has the patch of excellent results more.Patch of the present invention changes and the medicine of development at the etiology and pathogenesis of primary disease and patient's requirement, through preliminary clinical trial, really can obtain good curative effect.
Summary of the invention:
The invention provides a kind of anemofrigid-damp arthralgia medicine patch of rheumatic Bi syndrome of syndrome of blood stasis of holding concurrently for the treatment of, patch of the present invention is processed into as raw material with the Chinese medicine Daphne giraldii Nitsche.
The present invention also provides a kind of Daphne giraldii Nitsche extract, and the present invention makes patch of the present invention with the active component of this extract as medicine.
The preparation method that the present invention also provides Daphne giraldii Nitsche extract's preparation method and contains the patch of this extract.
The present invention also provides the patch that uses the Daphne giraldii Nitsche extract and contain this extract treating and/or preventing the anemofrigid-damp arthralgia application of medicine of rheumatic Bi syndrome of syndrome of blood stasis of holding concurrently.
Daphne giraldii Nitsche extract of the present invention adopts following prepared:
The step of process has: 1, Chinese medicine Daphne giraldii Nitsche raw material water extraction, 2, the extracting solution ethanol precipitation, 3, filter out the ethanol precipitation thing after, gained filtrate is removed ethanol, 4, use macroporous adsorption resin chromatography.
The step of Daphne giraldii Nitsche extract's process of the present invention has: 1, Chinese medicine Daphne giraldii Nitsche raw material water extraction, 2, extracting solution ethanol precipitation, 3, filter out the ethanol precipitation thing after, gained filtrate is removed ethanol, obtains extractum, and 4, this extractum water dissolution, 5, use macroporous adsorption resin chromatography, 6, water eluting, 30% ethanol elution, 80% ethanol elution successively, 7, collect 30% ethanol elution part
30% ethanol elution partly is the active part that contains extract of the present invention, and this part can obtain dried solid product through concentrate drying, and this solid product is a Daphne giraldii Nitsche dry extract of the present invention.
Daphne giraldii Nitsche extract of the present invention is characterized in that, wherein contains Daphnetin more than 23%, and this content can be measured and calculate with ultraviolet spectrophotometry.
The patch that contains Daphne giraldii Nitsche extract of the present invention of the present invention can prepare with the preparation method of conventional patch, and patch of the present invention can be the dosage form of unit dose, according to the needs of preparation, wherein can add the medicine acceptable carrier.The ratio of carrier can account for the 0.1-99.9% of composition weight ratio according to the needs of preparation, all the other are active component Daphne giraldii Nitsche extract of the present invention, the amount of active component can be 1-100mg in the preparation of unit dose, 2-50mg preferably, 5--10mg more preferably, all the other are the medicine acceptable carrier.
Specifically can use following method preparation:
Every subsides (60cm
2) contain the patch of Daphne giraldii Nitsche extract powder 7.8mg:
1.1 prescription
Daphne giraldii Nitsche extract 1.40g
Acrylic resin IV glue 286.50g
Mix homogeneously is coated with 10,000 cm
2, prepare 160 altogether and paste
1.2 acrylic resin IV glue prescription
Propylene ester resin IV 73.5g
Triethyl citrate 63.00g
Acetone 150.00ml
Mix homogeneously
Preparation technology:
(1) the Daphne giraldii Nitsche extract powder is crossed 60 mesh sieves.
(2) extract powder is dispersed in the acetone, forms suspension.
(3) preparation of adhesive solution is by 1.2 proportioning preparation.
(4) suspension with the Daphne giraldii Nitsche extract powder is dissolved in the acrylic resin IV glue, becomes uniform liquid.
(5) on coating machine, be coated with 40 ℃ of oven dry.
(6) backing layer in the covering, rolling, cutting, packing.
Below by pharmacodynamics test data declaration beneficial effect of the present invention, testing the medicine that uses is the medicine patch for preparing with the method in the embodiment of the invention 2, and name is called: subsides bitterly disappear.
The lagging skin stickup administration (0.768mg/ position, 0.275mg/ position, 0.047mg/ position) that disappears bitterly can obviously suppress carrageenin and induce rat paw edema, obviously reduces scorching sufficient PGE2 content.
Freund's complete adjuvant is inductive rat assist agent arthritis result show: the high, medium and low dosage of subsides that disappears bitterly can obviously suppress early stage inflammatory reaction and swelling once again after 13 days, can obviously suppress the foot swelling that the offside hind leg causes because of delayed hypersensitivity again, the subsides high and low dose that disappears bitterly action intensity is better than SHEXIANG ZHUIFENG GAO, middle dosage and SHEXIANG ZHUIFENG GAO broadly similar.
The pain infringements such as ear's erythema of pasting high, middle low dose group and SHEXIANG ZHUIFENG GAO group rat and afterbody lesser tubercle that disappear all alleviate than vehicle group is obvious.In the whole observation period, do not see that the animal ingestion amount obviously reduces; Pain disappears to paste does not have influence to the spleen weight of rat, high, middle dosage to thymic weight do not have influence, low dose group slightly increases, increase has significant effect to adrenal gland's weight.Mouse peritoneal capillary permeability due to the Dichlorodiphenyl Acetate increases the obvious suppression effect.Pain disappears to paste has the obvious suppression effect to the rat granuloma hypertrophy, and thymus is not had obvious influence, in, low dosage significantly increases adrenal gland's weight.The subsides that disappear bitterly suppress acetic acid and cause the mouse writhing reaction times, prolong mice burning pain threshold value.Pain disappears to paste and can significantly suppress the inductive mice delayed hypersensitivity of DNCB.The subsides that disappear bitterly can improve the mice carbon granule and clean up function.
It is the link of most critical in the Chinese patent medicine production process that Chinese medicine extraction is separated, and also is the key issue that restriction at present improves Chinese medicine quality.It directly has influence on the quality and the clinical efficacy of product.Invention has been determined effective site through further investigation, and effective ingredient has been formulated content assaying method, has effectively guaranteed the stability of product quality.
For guaranteeing product quality and curative effect, we have adopted advanced technology one macroporous adsorption resin technology aspect Chinese medicine extraction.We further investigate to extract used resin model, solvent, elution process etc., have finally determined optimized parameter, thereby have guaranteed effective site is extracted and content of effective fully, have also controlled the quality and the curative effect of product simultaneously.
Patch effective ingredient of the present invention is clear and definite, and curative effect is good, few side effects, and preparation stabilization, technology are simple, and the quality standard strictness has reached the requirement of " safety, efficient, stable, controlled " of modernized Chinese medicine.
The specific embodiment:
Further specify the present invention by the following examples.
Embodiment 1
Daphne giraldii Nitsche extract's preparation
49g Daphne giraldii Nitsche medical material, with water extraction three times, merging filtrate, filter, concentrate back 70% ethanol precipitation, filter out precipitation, get filtrate, the ethanol that reclaims in the filtrate is not distinguished the flavor of to there being alcohol, obtain 9.3g Daphne giraldii Nitsche extractum (proportion 1.20, paste-forming rate 19%), Daphne giraldii Nitsche water extracting alcohol hypostasis was in 1: 10 (V: ratio adding distilled water V), heating while stirring, filter, filtrate adds in the AB-8 type macroporous adsorbent resin handle well, successively the water eluting, 30% ethanol elution, it (is residue thing＜1mg=behind every 1000ml eluent evaporate to dryness that 80% ethanol elution, every part are washed till residue heavy＜1 ‰.Collect 30% pure eluting and partly obtain 1.4g Daphne giraldii Nitsche extract of the present invention.The consumption of macroporous resin wherein: press 1: 1 of Daphne giraldii Nitsche crude drug amount (weight: weight) the decision resin demand (such as, the Daphne giraldii Nitsche water extracting alcohol hypostasis that is obtained by 1kg Daphne giraldii Nitsche crude drug is with regard to the AB-8 type macroporous resin adsorption of handy 1kg).
Embodiment 2
Every subsides (60cm
2) contain the patch of Daphne giraldii Nitsche extract 7.8mg:
Prescription
Daphne giraldii Nitsche extract 1.40g
Acrylic resin IV glue 286.50g
Mix homogeneously is coated with 10,000 cm
2, prepare 160 altogether and paste
Acrylic resin IV glue prescription
Propylene ester resin IV 73.5g
Triethyl citrate 63.00g
Acetone 150.00ml
Preparation technology:
The Daphne giraldii Nitsche extract powder is crossed 60 mesh sieves.
Extract powder is dispersed in the acetone, forms suspension.
The preparation of acrylic resin IV glue.
The suspension of Daphne giraldii Nitsche extract powder is dissolved in the acrylic resin IV glue, becomes uniform liquid.
On coating machine, be coated with 40 ℃ of oven dry.
Backing layer in the covering, rolling, cutting, packing.
Embodiment 3
Prescription
Daphne giraldii Nitsche extract 1.40g
Polyacrylate glue 286.50g
Mix homogeneously is coated with 10,000 cm
2, prepare 160 altogether and paste
Preparation technology:
The Daphne giraldii Nitsche extract powder is crossed 60 mesh sieves.
Extract powder is dispersed in the acetone, forms suspension.
The preparation of polyacrylate glue.
The suspension of Daphne giraldii Nitsche extract powder is dissolved in the polyacrylate glue, becomes uniform liquid.
On coating machine, be coated with 40 ℃ of oven dry.
Backing layer in the covering, rolling, cutting, packing.
Claims (3)
1. treat the hold concurrently Chinese herbs paste of rheumatic Bi syndrome of syndrome of blood stasis of anemofrigid-damp arthralgia for one kind, it is characterized in that, its active component is to be the extract that raw material is made with the Chinese medicine Daphne giraldii Nitsche, described extract, wherein contain Daphnetin more than 23%, its preparation process following steps: 1, Chinese medicine Daphne giraldii Nitsche raw material water extraction, 2, the extracting solution ethanol precipitation, 3, after filtering out the ethanol precipitation thing, gained filtrate is removed ethanol, obtains extractum, 4, this extractum water dissolution, 5, use macroporous adsorption resin chromatography, 6, water eluting successively, 30% ethanol elution, 80% ethanol elution, 7, collect 30% ethanol elution part.
2. the patch of claim 1 is the dosage form of unit dose, and wherein active component Daphne giraldii Nitsche extract's amount is 1-100mg in the preparation of unit dose; All the other are the medicine acceptable carrier.
3. the patch of claim 1 is characterized in that, preparation 160 is pasted the used raw material of patch and is
Daphne giraldii Nitsche extract 1.40g
Acrylic resin IV glue 286.50g
Wherein acrylic resin IV glue is write out a prescription
Propylene ester resin IV 73.5g
Triethyl citrate 63.00g
Acetone 150.00ml.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410006205 CN1286492C (en) | 2004-03-11 | 2004-03-11 | Traditional Chinese medicinal plaster |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410006205 CN1286492C (en) | 2004-03-11 | 2004-03-11 | Traditional Chinese medicinal plaster |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1559466A CN1559466A (en) | 2005-01-05 |
| CN1286492C true CN1286492C (en) | 2006-11-29 |
Family
ID=34439739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410006205 Expired - Fee Related CN1286492C (en) | 2004-03-11 | 2004-03-11 | Traditional Chinese medicinal plaster |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1286492C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1883618B (en) * | 2005-06-21 | 2011-09-07 | 天津药物研究院 | Effective parts of cirald daphne bark, preparation method and application thereof |
| CN101518599A (en) * | 2009-03-24 | 2009-09-02 | 沈阳药科大学 | Slow-release patch with daphne giraldii bark extract, and preparation method thereof |
-
2004
- 2004-03-11 CN CN 200410006205 patent/CN1286492C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1559466A (en) | 2005-01-05 |
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| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |