CN1251711C - External use anti-inflammatory and myogenic medicine of chinese medicine and its preparing method - Google Patents
External use anti-inflammatory and myogenic medicine of chinese medicine and its preparing method Download PDFInfo
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- CN1251711C CN1251711C CNB2003101217900A CN200310121790A CN1251711C CN 1251711 C CN1251711 C CN 1251711C CN B2003101217900 A CNB2003101217900 A CN B2003101217900A CN 200310121790 A CN200310121790 A CN 200310121790A CN 1251711 C CN1251711 C CN 1251711C
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Abstract
The present invention relates to an external use anti-inflammatory and myogenic medicine of Chinese medicines, which is paste prepared from the raw materials with the following weight percentage: 12 to 20% of hoveniae semoveniae semen powder, 32 to 40% of cuttlebone powder, 2 to 6% of borneol and 38 to 54% of substrates of ointment (30 to 38% of vaseline and 8 to 16% of sesame oil). The present invention has the following method: (1) the hoveniae semoveniae semen powder and the cuttlebone are respectively made into thin powder, and the borneol is ground; (2) the raw materials are weighed; (3) the vaseline is taken, and the sesame oil is filled to make the vaseline melted; (4) the hoveniae semoveniae semen powder and the cuttlebone powder are uniformly mixed; (5) borneol powder is taken, is added into mixed liquid obtained by step (3) and is agitated to melt; then, the mixed powder obtained by step (4) is added and is uniformly mixed, and after natural cooling, the external use anti-inflammatory and myogenic medicine of Chinese medicines is obtained. The medicine of the present invention is suitable for acute and chronic mastitis, cracked nipple, abscess swollen boil, cellulitis, trauma infection, burning, scalding and scorching infection, and local infection caused by injection, operations and acupuncture and moxibustion. The present invention can treat new wound and burn. The early usage of the product can prevent infection and increase treating effects.
Description
Technical field
The present invention relates to a kind of Chinese medicine externally applied anti-inflammation granulation promoting medicine and preparation method thereof, is to belong in the surgical infection field, the Chinese medicine preparation of treatment body surface soft tissue acute and chronic infection.
Background technology
At present, the Western medicine of treatment suppurative infection mainly is various antibiotics.Close with technology of preparing of the present invention, the Chinese medicine preparation of treatment body surface soft tissue acute and chronic infection has: ruyi jinhuang powder, ruyi jinhuang san, Shengji Yuhong Gao, JIUYISAN, the cream of drawing out pus by applying a plaster to the affected part, zijin troche, troche of toad venom.
Their shortcoming is: Western medicine complicated process of preparation, equipment requirements height.Therefore cost an arm and a leg, in clinical practice, must bring various injections, oral treatment misery.And be easy to take place anaphylaxis, hepatic and renal function injure, generation drug resistance, dysbacteriosis, medical expense big, the human internal environment is disturbed shortcomings such as big.And in the Chinese medicine preparation of known treatment body surface soft tissue acute and chronic infection, all contain toxic substance again, and as: Hydrargyri Oxydum Rubrum, Rhizoma Arisaematis, Calomelas, Plumbum preparatium, Venenum Bufonis, Cinnabaris, Realgar etc.Therefore treat safety, be easy to be affected.
Summary of the invention
The purpose of this invention is to provide and a kind ofly not contain any poisonous and harmful composition, the medicine source is extensive, cheap, curative effect is high, short treating period, cost are low, drug safety Chinese medicine externally applied anti-inflammation granulation promoting medicine easily.
A further object of the present invention provides the simple Chinese medicine externally applied anti-inflammation of a kind of technology granulation promoting process for preparing medicine.
For achieving the above object, the present invention takes following technical scheme:
A kind of Chinese medicine externally applied anti-inflammation granulation promoting medicine, it is the unguentum of being made by following weight percentages:
The substrate 38-54% of Semen Hoveniae (Fructus Hoveniae) powder 12-20%, cuttlefish bone meal 32-40%, the broken last 2-6% of Borneolum Syntheticum, ointment.
The substrate that ointment is commonly used has vaseline, liquid paraffin, Pilus Caprae seu Ovis matter, Cera Flava, animal oil, vegetable oil, single stearic acid glyceride, octadecanol etc. and composition thereof.According to the temperature height, can add the soft durometer that proper amount of paraffin or liquid paraffin are adjusted substrate.Can add emulsifying agent in some substrate and make emulsion-type ointment, make medicine easily by skin absorbs, and easily eccysis.These all belong to routine techniques.In Chinese medicine externally applied anti-inflammation granulation promoting medicine of the present invention, the matrix optimization of described ointment is vaseline and Oleum sesami, and wherein, their percentage by weight is: vaseline 30-38%, Oleum sesami 8-16%.
A kind of preparation method of Chinese medicine externally applied anti-inflammation granulation promoting medicine, this method comprises the steps:
(1), Semen Hoveniae (Fructus Hoveniae), Os Sepiae are made fine powder respectively, Borneolum Syntheticum is ground, standby;
(2), take by weighing following weight percentages:
Semen Hoveniae (Fructus Hoveniae) powder 12-20%, cuttlefish bone meal 32-40%, the broken last 2-6% of Borneolum Syntheticum, vaseline 30-38%, Oleum sesami 8-16%;
(3), get the vaseline of above-mentioned percentage by weight, add the Oleum sesami of above-mentioned percentage by weight, be heated to 40-60 ℃, make it to melt;
(4), get Semen Hoveniae (Fructus Hoveniae) powder, the cuttlefish bone meal of above-mentioned percentage by weight, evenly mixed;
(5), again get the broken end of Borneolum Syntheticum of above-mentioned percentage by weight, add in the mixed liquid that step (3) obtains, stir, add the mixed powder that step (4) obtains again and stir evenly, promptly obtain Chinese medicine externally applied anti-inflammation granulation promoting medicine behind the natural cooling to melting.
In the preparation method of above-mentioned Chinese medicine externally applied anti-inflammation granulation promoting medicine, in described step (1), Semen Hoveniae (Fructus Hoveniae), the made fine powder of Os Sepiae all reach whole energy by No. 5 sieves, and the powder that wherein contains by No. 6 sieves is no less than 95% standard.
In the preparation method of above-mentioned Chinese medicine externally applied anti-inflammation granulation promoting medicine, in described step (2), employed Oleum sesami is 20-30 minute sterilization process of process 10-12 pound in autoclave in advance.
In the preparation method of above-mentioned Chinese medicine externally applied anti-inflammation granulation promoting medicine, all operating process need keep away in the collarium border in cleaning and carry out.
In the preparation method of above-mentioned Chinese medicine externally applied anti-inflammation granulation promoting medicine, made Chinese medicine externally applied anti-inflammation granulation promoting medicine need be packed in the aseptic shading container.
Semen Hoveniae (Fructus Hoveniae) used in the present invention belongs to the Rhamnaceae plant, the seed of Semen Hoveniae (Fructus Hoveniae).Another name: chicken feet, golden hook, chicken feet pears, smelly Fructus Lycii (Jiangsu).Originate in Central-South, East China, North China, northwest and southwest, be born in limes marginis, roadside and mountain valley.Have cultivation to gather the 10-11 month,, brownish red person big with full plumpness, grain is for well.Sweet in the mouth is flat, goes into stomach warp, alcoholic intoxication, emesis, diuresis.Cure mainly: (1) calentura excessive thirst, vomiting; (2) dysuria; (3) alcoholic intoxication.Compendium of Materia Medica is on the books, can (Nanjing Traditional Chinese Medical College's Chinese herbal medicine is write group and compiled, and the Jiangsu People's Press publishes, book number: 14100014) referring to " Chinese herbology＜middle volume〉".
Employed No. 5 sieves, No. 6 sieves are the state-promulgated pharmacopoeia sieve in the method for the present invention, select the pharmacopeia sieve of the R40/3 series of national standard for use.According to the medicine sieve specification of Chinese Pharmacopoeia nineteen ninety version regulation, the internal diameter meansigma methods of No. 5 sieves is 180 microns ± 7.6; The internal diameter meansigma methods of No. 6 sieves is 150 microns ± 6.6.According to the powder grading standard of Chinese Pharmacopoeia nineteen ninety version regulation, the standard of fine powder refers to all can pass through No. 5 sieve, and contains and can be no less than 95% powder by No. 6 sieves, also is desired fine powder standard in the method for the present invention.
Employed autoclave is medical common apparatus in the method for the present invention.
The advantage of Chinese medicine externally applied anti-inflammation granulation promoting medicine of the present invention is:
Medicine of the present invention has solved uses the shortcoming that exists in antibiotics and the suppuration of some Chinese medicine preparation treatment soft tissue infection in the surgical infection field, promptly solved shortcomings such as anaphylaxis, hepatic and renal function injure, dysbacteriosis, treatment misery, the medical expense using Western medicine and bring are big, Chinese medicine preparation contains toxic substance, drug safety is affected.And medicine of the present invention belongs to pure Chinese medicinal preparation, the medicine source is extensive, preparation technology simply, does not contain any poisonous and harmful composition, cheap, curative effect is high, short treating period, expenses for medicine is few, drug safety is convenient.
The pharmacological effect of Chinese medicine externally applied anti-inflammation granulation promoting medicine of the present invention: medicine of the present invention has heat-clearing and toxic substances removing, reducing swelling and alleviating pain, removing the necrotic tissue and promoting granulation, antiinflammatory and holds back the pharmacological effect of skin ulcer.
The using method of Chinese medicine externally applied anti-inflammation granulation promoting medicine of the present invention: at infection site, be coated with after settling accounts processing with medicine of the present invention, dressing covers, immobilization with adhesive tape, and change once every day.Need cut evacuation of pus to deep infection suppuration person, and the medicine sliver drain of making of built-in medicine of the present invention.To small size burning, the wounded of scalding, burn, use medicine of the present invention to be applied to the affected part as early as possible, every day 2-3 time, need not to use disinfectant.To fresh wound, after clean, be coated with medicines dressing covering of the present invention, immobilization with adhesive tape, change once every day.No matter which kind of situation before changing dressings, all should be removed residual liquor and liquefaction thing, exposes wound surface.For burning, scald, burn the wounded, do not wrap up as far as possible, expose medication.
The use amount of Chinese medicine externally applied anti-inflammation granulation promoting medicine of the present invention: courses of pharmaceuticals of the present invention was 1 week.Nonspecific infection, fresh wound, recovery from illness in the course of treatment.Severe infections, recovery from illness in 2 courses of treatment.The following burn and scald of II degree, the recovery from illness course of treatment.The above person of II degree, recovery from illness in 2 courses of treatment.
The indication of Chinese medicine externally applied anti-inflammation granulation promoting medicine of the present invention: medicine of the present invention is applicable to the local infection that acute and chronic mastitis, cracked nipple, abscess furuncle and phyma, cellulitis, trauma infection contamination, burn and scald infection and injection, operation, acupuncture-moxibustion cause.Fresh wound, burn are used medicine of the present invention early, but prevention infection improves curative effect.
For showing the therapeutic effect of medicine of the present invention to treatment mastitis, body surface soft tissue infection and treatment cracked nipple, the present invention is reported as follows through treatment mastitis 51 routine observation of curative effect, treatment body surface soft tissue infection's 45 routine observation of curative effect and treatment cracked nipple 50 routine observation of curative effect:
(1), treatment mastitis 51 routine observation of curative effect
Clinical data:
This group case, 38 examples are the women of rural households, 13 examples are career woman.Oldest 28 years old, minimum 21 years old, 23.96 years old mean age.The course of disease is the longest 30 days, and the shortest 2 days, average 9.2 days.Wherein not suppuration person's 18 examples, suppuration person's 33 examples.Cut evacuation of pus 29 examples, ulceration person 2 examples voluntarily are with syringe aspirate the pus repeatedly person's 2 examples, (because of the patient refuses to cut).All case was used the anti-inflammation drugs treatment before the treatment.Have 11 examples to use outside the antipyretic analgesics because of fever after the treatment, all case was not used anti-inflammation drugs.
Diagnostic criteria:
Adopt Qiu Fazu chief editor " high medical college teaching material-surgery " People's Health Publisher to publish.
Clinical manifestation: early stage Ipsilateral distending pain of the breast, can touch inflammatory masses and masses, along with disease progression, occur local red, swollen, hot, bitterly.And then the lump deliquescing, fluctuation is arranged, abscess forms.Whole body shows as in early days can be with heating, general malaise, and can have shiver with cold late period, hyperpyrexia, numeration of leukocyte raises.
Therapeutic Method:
Before abscess forms, local as early as possible external application this product, change once every day.If the person that has the General Symptoms uses the Western medicine anti symptom treatment.
After abscess forms, need to cut evacuation of pus and place the medicine sliver drain that this product is made, and external application this product is changed once every day.
Efficacy determination:
Recovery from illness: not suppuration person through treating after, pain disappears, local sign (lump) disappearance is followed up a case by regular visits to and was not recurred in 1 week.Suppuration person, no matter voluntarily ulceration or incision and drainage person, after treatment, pain disappears, and wound healing is followed up a case by regular visits to and is not recurred in 1-2 week.
Effectively: after the treatment, symptom, sign take a favorable turn.
Invalid: before and after the treatment, symptom, sign no change or automatic stopped treatment person.
Observation of curative effect:
This is organized in 51 examples, 46 examples of fully recovering; Effective 3 examples; Invalid 2 examples.The longest 3 days of analgesic time, the shortest 2 days, average 2.86 days.The longest 10 days of cure time, the shortest 6 days, average 7.34 days.Cure rate 90.19%, effective percentage 5.88%, inefficiency 3.92%, total effective rate 96.07%.
(2), treatment body surface soft tissue infection 45 routine observation of curative effect
Clinical data:
This is organized in 45 examples, furuncle and phyma, abscess 12 examples; Cellulitis 4 examples; Wound postoperative infection 18 examples; Acupuncture, injection, post-operative infection 6 examples; Concurrent infection 5 examples behind the small-area burn.All used the anti-inflammation drugs treatment before the case treatment.The course of disease is the longest 50 days, and the shortest 4 days, average 10.82 days.
Diagnostic criteria:
Adopt the Qiu Fazu chief editor, " high medical college teaching material-surgery " People's Health Publisher publishes.
Local symptom: red, swollen, hot, bitterly, dysfunction.
General Symptoms: the lighter can not have General Symptoms.Weight person has heating, general malaise, numeration of leukocyte to increase.
Sign: can detect local lump before abscess forms, companion's tenderness.After abscess forms, can detect fluctuation, in case of necessity, can puncture confirms the infection that wound, injection, operation, burn cause, above-mentioned every medical history should be arranged, and adds the clinical manifestation of suppurative infection again.That is, local symptom, General Symptoms, Signs.
Therapeutic Method:
Suppuration person not, local external application this product, change once every day.
Suppuration person needs to cut evacuation of pus, and makes the drain of medicine ointment ribbon gauze with this product, and the outside is still applied with this product, and change once every day.
The traumatic infection person, the cleaning wound surface directly spreads on the wound surface with this product then earlier, and change once every day, when changing dressings, should remove slough and left drug.
Curative effect determinate standard:
Recovery from illness: swelling disappears, and otch or wound healing are followed up a case by regular visits to and do not recurred in 1-2 week.
Effectively: local swelling alleviates, otch interior or wound surface, and purulent secretion reduces.
Invalid: no change before and after the treatment.
Observation of curative effect:
This organizes whole cases, does not add during the treatment to use any medicine.This is organized in 45 examples, 41 examples of fully recovering, effective 3 examples, invalid 1 example, cure rate 91.11%, effective percentage 6.66%, inefficiency 2.22%, total effective rate 97.77%.
The longest 11 days of cure time, the shortest 6 days, average 7.78 days.
(3), treatment cracked nipple 50 routine observation of curative effect
Clinical data:
This group 45 examples are the women of rural households, and 5 examples are career woman, maximum 30 years old of year order, minimum 21 years old.Primipara's 47 examples, multipara's 3 examples.The preceding course of disease of treatment the longest 50 days the shortest 4 days, average 10.72 days, all used the anti-inflammatory ointment external application for curing before the cases treatment, partly the once oral anti-inflammation drugs of crossing of case is treated, and is all invalid.
Diagnostic criteria:
Adopt the Zhou Zhongying chief editor, " the tcm clinical practice handbook, the People's Health Publisher, nineteen ninety-five second edition, new science and technology bibliography 349-149.
Clinical symptoms: during lactication, have an intense pain.Sign: nipple, mammary areola partly exfoliation form the breach that differs in size, and severe patient forms ulcer or nipple is partly damaged, and yellow purulent secretion is arranged during the surface.
The clinical development standard:
Recovery from illness: pain disappears, and the recurrence of 1 week is followed up a case by regular visits in breach or damaged healing.
Effectively: pain relief, breach or the healing of damaged part.
Invalid: no change before and after the treatment.
Therapeutic Method:
After clean wound is handled, directly apply with this product, clean medicine beginning residue during lactication, after lactication finishes, apply immediately, if the bilateral nipple is simultaneously ill, should replace lactication, should be blanking time more than 4 hours, use this product needn't stop suckling, should encourage lactication to reduce human milk silt on the contrary, mastitis are brought out in prevention.
Observation of curative effect:
This organizes whole cases, does not add during the treatment to use any medicine.This is organized in 50 examples, 45 examples of fully recovering, effective 3 examples, invalid 2 examples, cure rate 90%, inefficiency 4%, effective percentage 6%, total effective rate 96%.In 45 routine cured persons, the longest 4 days of analgesic time, the shortest 2 days, average 3.6 days.The longest 9 days of cure time, the shortest 6 days, average 7.85 days.
The specific embodiment
Embodiment
(1), select materials: Semen Hoveniae (Fructus Hoveniae): select big, full, the henna Semen Hoveniae (Fructus Hoveniae) of grain, remove impurity, clear water is cleaned, and dries standby.Os Sepiae: select the fair and clear Os Sepiae of color and luster, remove impurity, clear water is cleaned, and dries standby.Borneolum Syntheticum: select borneol or Blumeae preparatum Tabellae.Vaseline is selected medical white vaseline for use.Oleum sesami selects that color and luster is pale brown, limpid for use, free from admixture, no sedimentary Oleum sesami.
(2), prescription: Semen Hoveniae (Fructus Hoveniae): fine powder 16 grams; Os Sepiae: fine powder 36 grams; The broken end of Borneolum Syntheticum: 2 grams; Medical white vaseline: 34 grams; Oleum sesami: 12 grams.
(3), manufacture method:
A, Semen Hoveniae (Fructus Hoveniae), Os Sepiae are made fine powder respectively, promptly all can wherein can be no less than 95% by No. 5 sieves by the powder of No. six sieves.
Borneolum Syntheticum is ground standby.
Put in the autoclave Oleum sesami standby through 10 pounds of sterilizations in 30 minutes.
B, get vaseline 34 gram, add Oleum sesami 12 grams, be heated to 50 ℃, make it to melt.Get Semen Hoveniae (Fructus Hoveniae) powder 16 grams, cuttlefish bone meal 36 grams, the mixed powder of mixed evenly one-tenth.Get broken last 2 grams of Borneolum Syntheticum, add in the above-mentioned mixed liquid, stir, add above-mentioned mixed powder again and stir evenly, seal in the aseptic shading container of packing into to melting, behind the natural cooling for the treatment of promptly.
Wherein, whole operation cross range request clean, keep away in the collarium border and carry out.Employed crude drug Semen Hoveniae (Fructus Hoveniae) can therefrom be produced the 85-90% fine powder; Employed raw material Os Sepiae can therefrom be produced 95% fine powder; Employed raw material Borneolum Syntheticum can therefrom be produced 98% broken end.
In sum, Chinese medicine externally applied anti-inflammation granulation promoting medicine of the present invention is in clinical practice, and treatment is painful little.Because of it need not to have an injection, take medicine, only need external application, can obtain satisfactory effect.In addition, medicine of the present invention is safe in medication, convenient, fast.Because of medicine of the present invention belongs to pure Chinese medicinal preparation, nontoxic, harmless, have no side effect.As long as in the indication scope, can treat at hospital outpatient, or patient oneself treatment of being under physician guidance, need not in hospital.Medicine cost of the present invention is little, and the medicine source is extensive, and preparation technology is simple, thereby with low cost, adds the curative effect height, and short treating period is so just bring the big spoke of treatment cost to reduce.Through clinical trial certificate, use medicine of the present invention can reduce to 1/10th of present technology treatment cost.Medicine of the present invention can be used as the standing medicine of family, can use medicine of the present invention to treat fresh wound early, burn, scald, burn, abscess, furuncle and phyma from the beginning of, can obtain better curative effect undoubtedly, reduce painfully, cut down expenses.
Claims (5)
1, a kind of Chinese medicine externally applied anti-inflammation granulation promoting medicine, it is characterized in that: it is the unguentum of being made by following weight percentages:
The substrate 38-54% of Semen Hoveniae (Fructus Hoveniae) powder 12-20%, cuttlefish bone meal 32-40%, the broken last 2-6% of Borneolum Syntheticum, ointment.
2, Chinese medicine externally applied anti-inflammation granulation promoting medicine according to claim 1, it is characterized in that: the substrate of described ointment is vaseline and Oleum sesami, wherein, their percentage by weight is: vaseline 30-38%, Oleum sesami 8-16%.
3, a kind of preparation method of Chinese medicine externally applied anti-inflammation granulation promoting medicine, it is characterized in that: this method comprises the steps:
(1), Semen Hoveniae (Fructus Hoveniae), Os Sepiae are made fine powder respectively, Borneolum Syntheticum is ground, standby;
(2), take by weighing following weight percentages:
Semen Hoveniae (Fructus Hoveniae) powder 12-20%, cuttlefish bone meal 32-40%, the broken last 2-6% of Borneolum Syntheticum, vaseline 30-38%, Oleum sesami 8-16%;
(3), get the vaseline of above-mentioned percentage by weight, add the Oleum sesami of above-mentioned percentage by weight, be heated to 40-60 ℃, make it to melt;
(4), get Semen Hoveniae (Fructus Hoveniae) powder, the cuttlefish bone meal of above-mentioned percentage by weight, evenly mixed;
(5), again get the broken end of Borneolum Syntheticum of above-mentioned percentage by weight, add in the mixed liquid that step (3) obtains, stir, add the mixed powder that step (4) obtains again and stir evenly, promptly obtain Chinese medicine externally applied anti-inflammation granulation promoting medicine behind the natural cooling to melting.
4, the preparation method of Chinese medicine externally applied anti-inflammation granulation promoting medicine according to claim 3, it is characterized in that: in described step (1), Semen Hoveniae (Fructus Hoveniae), the made fine powder of Os Sepiae all reach whole energy by No. 5 sieves, and the powder that wherein contains by No. 6 sieves is no less than 95% standard.
5, according to the preparation method of claim 3 or 4 described Chinese medicine externally applied anti-inflammation granulation promoting medicines, it is characterized in that: in described step (2), employed Oleum sesami is 20-30 minute sterilization process of process 10-12 pound in autoclave in advance.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2003101217900A CN1251711C (en) | 2003-12-24 | 2003-12-24 | External use anti-inflammatory and myogenic medicine of chinese medicine and its preparing method |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2003101217900A CN1251711C (en) | 2003-12-24 | 2003-12-24 | External use anti-inflammatory and myogenic medicine of chinese medicine and its preparing method |
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| CN1554423A CN1554423A (en) | 2004-12-15 |
| CN1251711C true CN1251711C (en) | 2006-04-19 |
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| CNB2003101217900A Expired - Fee Related CN1251711C (en) | 2003-12-24 | 2003-12-24 | External use anti-inflammatory and myogenic medicine of chinese medicine and its preparing method |
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| CN102716415B (en) * | 2012-06-01 | 2013-11-06 | 蒋金洲 | External-use traditional Chinese medicine composition for treating body surface abscess |
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Granted publication date: 20060419 Termination date: 20121224 |