CN1313117C - Chinese medicine external applied powder for bone damage - Google Patents

Abstract

The present invention relates to traditional Chinese medicine external application preparation for treating bone injuries, which belongs to the technical field of Chinese herbal medicine external application products. Components of south cortex acanthopanacis, cassia twig, Danshen root, cape jasmine, vinegar and eggs are prepared into paste which is spread and coated on a gauze and then is applied to the positions of bone injuries, and a bandage and a clamp plate are used for fixing the gauze to treat bone injuries. The present invention has the characteristics of rapidly curing bone injuries mainly by relieving wind-cold-dampness in a fracture position to strengthen tendons and bones and auxiliary by releasing muscle skin, stimulating blood circulation to end stasis and cooling blood heat and solving the problems of multiple components, poor therapeutic effect, high cost of operative treatment and high pain degree of the existing Chinese herbal medicine patent medicine for treating bone injuries. The present invention has the advantages of simple treating method, easy acquirement of raw materials, rapid pain relieving, low cost and high cure rate of more than 90%, and is suitable for treating bone injuries in various positions of a human body.

Description

The bone injury external application of Chinese medicine is loose

Affiliated technical field:

The present invention relates to a kind of external application of Chinese medicine preparation for the treatment of skeletal injury, belong to Chinese herbal medicine external goods field.

Background technology:

The skeleton damage is the inevitably normal in daily life experiences of people, as sometimes work, when living, walk, doing physical work or enure, under careless, contingency or situation about overexerting, the fracture or the articular sprain, particularly middle-aged and elderly people that human body a part then can occur are particularly common.As the saying goes " 100 days injured in the sinews or bones ", therefore, it is long especially that this type of disease patient cures the cycle, and pain unbearably.The mode of set a broken bone has multiple, mainly is divided into western medical treatment and Chinese traditional treatment two big classes, and wherein western medicine has captured world's leading position.Can adopt operative reduction, steel plate internal fixation to add external plaster fixation for closed fracture is many.Though this method can be very fast with the reduction of the fracture, for human fracture position muscle very big damage arranged, and is unfavorable for the healing of fracturing.Steel plate itself also can cause occlusion effect, thereby causes the sclerotin generation decadence atrophy of fracture site, and Gypsum Fibrosum can stop blood circulation, accelerates the atrophy of muscle, and utilizes Gypsum Fibrosum can also cause that the joint boundary is hard for a long time, influences patient's normal activity.The Chinese medicine treating bone fracture has many kinds at present, but similar aspect medication, ignores primary and secondary.This blindness medication can cause that unavoidably medication is a lot of, and drug effect very a little less than, poor to the actual efficacy of bone injury focus, wherein all be based on blood circulation promoting and blood stasis dispelling, cooperate the skin irritation medicine simultaneously, alleviate patient's misery.This Therapeutic Method has certain therapeutical effect to traumatic blood stasis, but does not pay attention to damaging the purpose that remove the wind-cold damp pathogen of fracture site and reach hard muscles and bones in compatibility.

Summary of the invention:

The objective of the invention is to: provide a kind of and overcome bone injury operative treatment misery greatly, high and the existing treatment by Chinese herbs prescription of expense is complicated, the deficiency of therapeutic effect difference, hard muscles and bones is monarch with CORTEX ACANTHOPANACIS releasing fracture site wind-cold damp pathogen in employing, and help Ramulus Cinnamomi with expelling pathogenic factors from muscles table, Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling, Fructus Gardeniae removing heat from blood heat, so that the bone injury external application of Chinese medicine of bone injury quickly-healing is loose.

The present invention realizes above-mentioned purpose by following technical solution.

It is the unguentum of being made by following weight percentages that this bone injury external application of Chinese medicine is loose:

CORTEX ACANTHOPANACIS 12.5% Ramulus Cinnamomi 7.5% Radix Salviae Miltiorrhizae 6.25%

Fructus Gardeniae 5% vinegar 8.75% egg 60%

Preparation method of the present invention is as follows:

After above-mentioned CORTEX ACANTHOPANACIS, Ramulus Cinnamomi, Radix Salviae Miltiorrhizae, Fructus Gardeniae four Chinese medicine thing taken by weighing by above-mentioned percentage by weight, be ground into 200 purpose smalls, taking by weighing vinegar and egg and smalls by above-mentioned percentage by weight again, to be modulated into ointment stand-by.

Usage: with the size that above-mentioned ointment is pressed fracture site, the stand is applied on the gauze, spreads on the bone injury position outward, and is fixed with binder and clamping plate.Changed dressings once in per three days, and fully recovered to bone injury.Slight wound bone injury patient pain relieving in 12 hours can be cured in general 15 days.Severely injured bone injury patient pain relieving in 48 hours can be cured in general 30 days.

Technical solution of the present invention is based on Chinese medicine to pathogenetic research of bone injury and Therapeutic Principle, with reference to the scientific achievement of modern pharmacological research to inner disease outer treat, by the theory of Chinese medical science prescription, the dosage that breaks traditions is little, the taboo that medical material is assorted and many, it is fewer but better that it is accomplished in medical material is accepted or rejected, and makes a distinction between the important and the lesser one, the synergism of mutual compatibility is to remove bone injury position wind-cold damp pathogen, hard muscles and bones; With expelling pathogenic factors from muscles table, blood circulation promoting and blood stasis dispelling, clearing away heat and cooling blood is auxilliary, makes the bone injury quickly-healing.

The pharmacology and the drug effect of above-mentioned each raw material components of the present invention are as follows;

CORTEX ACANTHOPANACIS: Xin Wen has the promoting blood circulation to remove obstruction in the collateral effect, can treat obstructed, the qi and blood stagnation of blood vessels.

Pharmacological action: 1. calmness, analgesia.

2. obviously improve the phagocytic activity of macrophage, improve hemorheology,

Antithrombotic forms.

3. accelerating union of bone fracture, experiment show and improve rat femur hardness,

Carry high calcium and phosphorus and protein percentage composition in bone, and impel bone

The calcium deposition.

Organism metabolism and immunity are influenced:

1. to carbohydrate metabolism and energy metabolism: promote the intramuscular glycogen synthetic in resting state,

Promote the metabolism of sugar at the volley, satisfy the needs of body energy.

2. to protein and nucleic acid metabolism influence: CORTEX ACANTHOPANACIS is synthetic to protein nucleic acid

Short effect is arranged, and it is synthetic to strengthen DNA.

3. to lipometabolic influence: CORTEX ACANTHOPANACIS promotes fat in the oxidation reaction transfer

Become the energy supply of musculation, improve human body environmental catastrophe or certain strong

The stress ability of degree noxious stimulus.

Ramulus Cinnamomi: the hot temperature of Ramulus Cinnamomi, can lead medicine to sore spot, the expectorant blood coagulation stagnates warming the meridian and promoting blood circulation between podomere to remove.Kind

Go into blood system, be the key medicine of warm promoting blood circulation.

Pharmacological action: calm, analgesia, Ramulus Cinnamomi can improve the threshold of pain.The Oleum Cinnamomi energy that Ramulus Cinnamomi is contained

Distend the blood vessels, adjust blood circulation, make blood flow to body surface, thereby

Help diaphoresis and heat radiation.

Influence to inflammation and immunocompetence: Ramulus Cinnamomi is penetrating to the blood capillary of rat acute inflammation

The property increase, and carrageenin foot sole of the foot edema all has

Inhibitory action is to chronic adjuvant-induced arthritis model

Preventive effect is arranged, can prevent its whole body Secondary cases

The generation of symptom.

Anticoagulant: Ramulus Cinnamomi aldehyde has inhibitory action external to platelet aggregation, and Ramulus Cinnamomi Volatile oil can also

Impel netted Intradermal system phagocytic activity.

Radix Salviae Miltiorrhizae: blood circulation promoting and blood stasis dispelling, removing heat from blood mind calming, detumescence.Control cold and hot labor, arthralgia, extremity are unsuccessful,

The evacuation of pus pain relieving, granulation promoting is put on flesh, and broken stagnated blood is mended new hemopoietic.

Pharmacological action: tangible calmness, analgesic activity are arranged, Radix Salviae Miltiorrhizae expansion periphery fine motion CUN KOU

Directly, improve hemorheological property, anticoagulant, activate fibrinolytic, Radix Salviae Miltiorrhizae

Can strong promotion fibrin cracking FDP.Promote soft tissue more

Close, quicken DNA and synthesize, Radix Salviae Miltiorrhizae can make blood capillary proliferation, inflammation

Thin fertile few, granulation forms early, and fibroblast quantity is many, promotes bone

The folding healing.Radix Salviae Miltiorrhizae can make the primitiveness callus, the Secondary cases growth of spur,

And zinc content and zinc, copper ratio quicken tissue growth in the raising callus

And calcification process.

Bacteriostasis: Radix Salviae Miltiorrhizae is external to vibrio cholera, staphylococcus, tubercule bacillus, large intestine

Bacillus, Bacillus proteus, Bacillus typhi all has inhibitory action.

Fructus Gardeniae: control haematemesis, epistaxis, dysentery, hematochezia, stranguria with blood, traumatic blood stasis and typhoid fever recurrence caused by overexertion, heat

The headache due to upward adverse flow of channel-QI, hernia, burn and scald.

Pharmacological action:

1. the Fructus Gardeniae alcohol extract has obvious calmness, analgesic, analgesic activity.

2. Fructus Gardeniae has the resisting pathogenic microbes effect.The cape jasmine fruit hot water extract can stimulate external

The bovine aortic endothelial cell hypertrophy of cultivating is promoted 3H-thymus pyrimidine and deoxidation nuclear

Sweet ¹⁴C-is leucic to be mixed.Promote DNA and protein in the cell, make blood

The pipe inner membrance is repaired.The ethyl acetate dissolving part of Fructus Gardeniae alcohol extract, methanol

The dissolving part has better therapeutical effect to mice and rabbit soft tissue injury.

Egg: fat is to form cell in the egg, keeps tissue growth, upgrades and repaiies

The Main Ingredients and Appearance of multiple cell tissue.

1. keep the normal colloid osmotic pressure of blood.

2. the buffer system of forming blood.

3. transport nutrition and metabolite.

4. participate in blood coagulation and immunization.

Vinegar: subduing inflammation, aproll gas, virus killing is evil.

Pharmacological action: vinegar is to influenza virus, alpha streptococcus, micrococcus catarrhalis, the two balls of pneumonia

Bacterium, Staphylococcus albus and hemophilus influenza have bactericidal action.

Application notice of the present invention:

To open fracture, the debridement and suturing of should going ahead of the rest, this ointment of external application again.

The present invention compared with prior art has following beneficial effect:

1. avoid operative treatment, alleviate the patient suffering.

2. the medical material choice is classical, makes a distinction between the important and the lesser one, and it is many to have overcome existing Chinese medicine patent medicine component, and the drawback of weak curative effect is easy to use.

3. Transdermal absorption is good, and by the synergism of each flavor medicine, affected area can go directly.

4. raw material is easy to get, and medical expense is low, and the patient is not had any toxic side effect.

5. good effect, it is fast to remove bone injury position pain, and healing time is short.

For showing therapeutic effect of the present invention, by 50 routine patients have been carried out system's clinical observation, its result is as follows:

1. physical data:

50 routine patients all are patient with bone fracture, and the age is 10-65 year, and light bone the wounded 32 people, heavy bone the wounded 18 people, 48 people be prescription on individual diagnosis in 1-2 days after the bone injury, and 2 people are the light bone injury of old.

2. Therapeutic Method:

Above-mentioned 50 routine patients all use Drug therapy of the present invention, earlier with the cleaning of patient affected part, manual reduction, be applied to medicine unguentum of the present invention on the gauze again after, spread on the bone injury position, and be fixed with binder and clamping plate.Changed dressings once in per three days, light the wounded 15th was a course of treatment, and heavy the wounded 30th was a course of treatment.

3. therapeutic effect:

3.1 criterion of therapeutical effect: excellent: pain relieving in light the wounded 12 hours, recovery from illness on the 15th, pain relieving in heavy the wounded 48 hours, recovery from illness on the 30th.Very: pain relieving in light the wounded 24 hours, recovery from illness on the 15th, pain relieving in heavy the wounded 4 days, recovery from illness on the 30th.Generally: pain relieving in light the wounded 48 hours, recovery from illness on the 20th, pain relieving in heavy the wounded 6 days, recovery from illness on the 40th.

3.2 therapeutic effect:

The bone injury external application of Chinese medicine is loose to 50 routine patient treatment analysis of results table

Therapeutic effect	Excellent	Very	Generally
				40 people (wherein slight wound 25 people, severely injured 15 people)	8 people (wherein slight wound 4 people, severely injured 2 people, old bone injury 2 people)	2 people (wherein slight wound 1 people, severely injured 1 people)
	Percentage rate (%)	80％	16％				4％

The specific embodiment:

The invention will be further described below in conjunction with specific embodiment:

Embodiment: (is example to produce 400g unguentum of the present invention)

1. take by weighing raw material by following weight:

CORTEX ACANTHOPANACIS 50g Ramulus Cinnamomi 30g Radix Salviae Miltiorrhizae 25g

Fructus Gardeniae 20g vinegar 35g egg 240g

Reaching technology as follows is prepared:

The above-mentioned CORTEX ACANTHOPANACIS that takes by weighing, Ramulus Cinnamomi, Radix Salviae Miltiorrhizae, Fructus Gardeniae four Chinese medicine thing are ground into 200 purpose smalls, and blue or green to be modulated into ointment stand-by with smalls with the vinegar that takes by weighing and egg again.

3. after the ointment preparation is finished, treat as follows:

With the size that above-mentioned ointment is pressed fracture site, the stand is applied on the gauze, spreads on the bone injury position outward, and is fixed with binder and clamping plate.Changed dressings once in per three days, and fully recovered to bone injury.Slight wound bone injury patient pain relieving in 12 hours can be cured in general 15 days.Severely injured bone injury patient pain relieving in 48 hours can be cured in general 30 days.

Model case:

Case 1:

The patient, Hu Jingsong, man, 26 years old.Cause: " left arm wound, swell and ache moving obstacle 1 day " is admitted to hospital.The patient falls down by bike accidentally in 1 day cause, and promptly feel the left arm injury at that time and have an intense pain, companion's swelling, stiff.I institute go to a doctor emergency, with " left humerus stage casing comminuted fracture ", take in my section behind the patient examination.Have a medical check-up: vital signs stable, the obvious swelling in left arm stage casing, visible blood stasis, ecchymosis are kowtowed rash (+), lay one's hand on and bone wiping sense, hear and bony crepitus.Be admitted to hospital the back with the diffusing treatment of the bone injury external application of Chinese medicine 20 days, conditions of patients recovery from illness.

Case 2:

The patient, field honeybee, man, 43 years old.Cause: " right lower limb wound 40 days " is admitted to hospital.When the patient worked, weighed wounded right lower limb by weight accidentally before 40 days, promptly feel the outer pain of right lower limb at that time, swelling, limitation of activity.Suddenly sent into local outpatient service smelting by other people and treat, patient diagnosis is " an epimere oblique fracture in the right tibiofibula ".Para-position is good to line, and treats January with transfusion antiinflammatory and external plaster fixation.Patient still pain is obvious, limitation of activity.My institute's treatment is sent into by other people in the back, behind the patient examination, take in my section with " epimere oblique fracture in the right tibiofibula ", human health screening: vital signs stable, the obvious atrophy of right leg muscle, right patella joint boundary is hard, the still visible blood stasis of epimere, ecchymosis in the shank, shank movable function obstacle, dermal sensation is poor, and end blood circulation slightly can.Be admitted to hospital the back with right leg with the bone injury external application of Chinese medicine treatment 35 days of loosing, patient's right leg does not have pain, joint motion freely, the shank muscular strength is good, state of an illness recovery from illness is left hospital.

Claims (1)

1. the bone injury external application of Chinese medicine is loose, and it is characterized in that it is made by following weight percentages:

CORTEX ACANTHOPANACIS 12.5% Ramulus Cinnamomi 7.5% Radix Salviae Miltiorrhizae 6.25%

Fructus Gardeniae 5% vinegar 8.75% egg 60%.