CN1253179C - Drug for treating ischemic necrosis of femoral head - Google Patents
Drug for treating ischemic necrosis of femoral head Download PDFInfo
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- CN1253179C CN1253179C CNB021355770A CN02135577A CN1253179C CN 1253179 C CN1253179 C CN 1253179C CN B021355770 A CNB021355770 A CN B021355770A CN 02135577 A CN02135577 A CN 02135577A CN 1253179 C CN1253179 C CN 1253179C
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Abstract
The present invention relates to a medicine for treating ischemic necrosis of a femoral head, particularly to a Chinese medical preparation for treating ischemic necrosis of a femoral head. The medicine is mainly formed by mixing 19 components, such as astragalus root, Chinese angelica root, (salt) psoraleae, (calcined) pyritum, cinnamon, drynaria, (processed) pangolin, safflower, sanguis draconis, prepared rhizome of rehmannia, antler glue, tortoise plastron, radix achyranthis bidentatae, (prepared) rhubarb, ground beetle, pulp of dogwood fruit, earthworm, raw dragon bone, scorpion, etc., in certain proportions by weight. The medicine of the present invention utilizes the comprehensive synergistic action of all the traditional Chinese medicines in scientific mixing proportions. The medicine of the present invention, which treats both manifestation causes and root causes of diseases, can effectively treat the ischemic necrosis of a femoral head, the total effective rate reaches 99%, and the cure rate and the basic cure rate can reach 67%. The medicine of the present invention is convenient to take without having any poisonous effect or side effect.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of femur head necrosis, be specifically a kind of be the pure Chinese medicinal preparation of the treatment ischemic necrosis of femoral head that is made of raw material with the Chinese herbal medicine.
Background technology
Femur head necrosis is a kind of common multiple disease, and wherein ischemic necrosis is the most general, belongs to traditional Chinese medical science rheumatism involving the bone, osteomyelitis category, and such disease has a strong impact on people's physical and mental health and normal quality of life, and the patient with severe symptoms is ill disables, and suffers untold misery.The clinical symptoms of ischemic necrosis of femoral head can be divided early, middle and late three phases of phase.Early symptom: pain in the lumbar region, patient's pain of buttock, groin pain, the gonalgia, suffer from the limb fear of cold, movable unable, these symptoms do not appear on one's body the patient simultaneously, and one or two symptoms or several symptom appear in the someone, heavy when time thes be light, or short time just disappearance of appearance back, occur again after a while.Mid-term: the patient walks lamely, pain increases the weight of when walking about, function limitation.Late period symptom: suffer from that limb is walked lamely, pain is more serious during walking, obviously feel short legs, difficulty in walking is suffered from the limb muscle atrophia, and is unable, fear of cold, the difficulty of squatting down, outreach adduction difficulty.
At present the foreign treatment primary disease is replaced into the master simultaneously with operating substitution Ipsilateral femoral head or acetabular bone and femoral head, domestic also have a capital case of operating substitution, but the method is painful big, the expense height, after using a stage, understand increase along with the degree of wear, and ineffective gradually, also will replace again, be not ideal Therapeutic Method.Also have at present to be exclusively used in this sick Chinese medicine of treatment as " XIANLING GUBAO ", its main component is: Herba Epimedii, Radix Dipsaci, Fructus Psoraleae etc., and mainly act as the benefit bone and keep fit, reunion of bone, bone is good in tonifying YANG, gain feelings will.Can be used for prevention and treatment osteoporosis and osteoporosis, fracture, osteoarthritis, bone aseptic necrosis etc., but this kind medicine can not reach promoting the flow of QI in the collateral by warming the meridian, promoting the circulation of blood arteries and veins fully, impel the effect of new osteanagenesis through clinical proof, and the stability and the reliability of curative effect are lower.
Summary of the invention
The object of the present invention is to provide a kind of medicine for the treatment of ischemic necrosis of femoral head, but liver and kidney tonifying, bone strengthening continues muscle, relaxing muscles and tendons and activating QI and blood in the collateral, and blood circulation promoting and blood stasis dispelling reaches sclerotin and recovers and the synchronous effect of recovering of function of joint.
Solution of the present invention is based on motherland's traditional medicine to pathogenetic understanding of femur head necrosis and Therapeutic Principle, adopt traditional secret recipe, in conjunction with the modern pharmacological research achievement, filter out liver and kidney tonifying, bone strengthening continues muscle, relaxing muscles and tendons and activating QI and blood in the collateral, blood circulation promoting and blood stasis dispelling class natural Chinese medicine forms according to the theory of Chinese medical science scientific matching.Each Chinese medicine of distinguishing the flavor of is collaborative to reach curative effect.
The present invention is achieved in that
The medicine of treatment ischemic necrosis of femoral head is characterized in that it is the medicament of being made by the component of following weight proportioning:
Radix Astragali 80-120 Radix Angelicae Sinensis 80-100 (salt) Fructus Psoraleae 60-100 (forging) Pyritum 50-75 Cortex Cinnamomi 30 Rhizoma Drynariae 60-100 (big gun) Squama Manis 50-75 Flos Carthami 50-75 Sanguis Draxonis 50-75 Radix Rehmanniae Preparata 50-75 Colla cornus cervi 50-75 Carapax et Plastrum Testudinis 50-75 Radix Achyranthis Bidentatae 40-50 (system) Radix Et Rhizoma Rhei 15-20 Eupolyphaga Seu Steleophaga 50-75 Fructus Corni 30-50 Pheretima 50-75 Os Draconis 150-200 Scorpio 50-75.
Medicine of the present invention is rich in necessary 18 seed amino acids of human body, trace element, and the necessary multiple nutrients material of human body.Can effectively suppress blood clotting, expansion blood villous themeda, dilution thromboembolism, activate fibrinolytic, improve capital inner blood supply environment, enhance metabolism, make necrotic bone drainages that be absorbed, reach the purpose of new osteanagenesis by the arterial blood keeping.
Modern pharmacology studies have shown that:
(1) Radix Astragali: contain also multiple sugar and r aminobutyric acid.Wherein glucose has immunologic enhancement.The r aminobutyric acid has the blood vessel dilating effect.This product also has invigorating QI to consolidate the body surface resistance, QI invigorating invigorating middle warmer effect.
(2) Radix Angelicae Sinensis, contain trace element such as calcium, copper, zinc, potassium, ferrum.Has blood circulation promoting and enriching, the effect of blood stasis removing.
(3) Fructus Psoraleae: contain psoralen (psoralen), copper, zinc microelement, and non-saponifying volatile oil have the controlling nocturnal emission with astringent drugs reducing urination, the effect of improving inspiration by invigorating the kidney.
(4) Pyritum: contain FeS
2And Fe
3O
4And copper.Wherein copper, ferrum can promote the hypertrophy of skein cell and hematochrome in bone marrow itself and the peripheral blood thereof.
(5) Cortex Cinnamomi: contain volatile oil, the active ingredient cinnamic aldehyde has blood vessel dilating in the oil, and anticoagulation and antithrombotic form, antipyretic-antalgic, antibacterial action.
(6) Rhizoma Drynariae: contain Fructus Citri grandis glycoside Rhizoma Drynariae flavanone composition, but the prophylactic serum cholesterol, triglyceride increases, and prevents that the atherosclerosis of aorta speckle from forming.The osteomiosis complementary energy promotes the absorption of bone to calcium, and increasing blood calcium and serium inorganic phosphorus level, thus favourable new bone formation, and obvious analgesic activity is arranged.
(7) stir-baked SQUAMA MANITIS: contain protein (92.6%) and calcium (0.08%), also contain 18 seed amino acids and the trace element of needed by human, have the expel wind to dredge collateral effect.
(8) Flos Carthami: contain carthamin, safflower oil, oleic acid, the peripheral circulation that has clear improvement effect and inhibition thrombosis, the level of reduction serum total cholesterol, total fat, glyceryl trinitrate acid and non-esterified fatty acid.Has blood circulation promoting and blood stasis dispelling, the removing obstruction in the collateral to relieve pain effect.
(9) Sanguis Draxonis: contain red resin 57%, promoting blood circulation to remove blood stasis is arranged, the effect of hemostasia and promoting granulation.
(10) Radix Rehmanniae Preparata: contain rehmanin, Camphor tree alcohol, vitamin A sample material and various saccharides, and the sweet acids of ammonia etc.Have cardiotonic, hypoglycemic activity.
(11) Colla cornus cervi: contain colloid, calcium phosphate, calcium sulfate, chloride and 17 kinds of aminoacid that health is had significant role, the various functions of enhancing body are arranged, promote cellular hemoglobin and reticulocyte new life, promote ulcer and wound healing.
(12) Carapax et Plastrum Testudinis: contain colloid, fatty calcium, phosphorus, zinc, manganese etc. have the raise immunity effect.
(13) Radix Achyranthis Bidentatae: contain the Periostracum Serpentis sterone, inokosterone and Saponin class composition, other contains peptide polysaccharide, reaches trace element such as ferrum, manganese, copper, zinc, cobalt.Has blood circulation and promoting silt, invigorating the liver and kidney, bone and muscle strengthening, conducting blood to flow downwards effect.
(14) Radix et Rhizoma Rhei (processed): contain emodin, chrysophanic acid, physcione etc.Radix et Rhizoma Rhei (stir-fried with wine) has the effect that promotes cell quantity increase, blood circulation promoting and blood stasis dispelling.
(15) Fructus Corni: the main compositions such as cornin, gallic acid, tartaric acid, vitamin A that contain.Get it and hold back healthy energy, the effect of circulation blood vessels, wine steams the back in order to strengthen its effect.
(16) Eupolyphaga Seu Steleophaga: contain alkaloid, aminoacid, protein, organic acid, acids, saccharide.Contained serine protease to the activation of human body plasminogen, is used for blood stasis dysmenorrhoea, and the muscles and bones folding is hindered.
(17) Scorpio: contain charybdotoxin, have expelling wind and relieving convulsion, the effect of qi and blood circulation promotion removing obstruction in the collateral to relieve pain.
(18) Pheretima: contain several amino acids, have dredge the meridian passage, the effect of stasis-dispelling and pain-killing.
(19) Os Draconis: contain calcium carbonate, calcium phosphate.Because of containing the composition of a large amount of calcium, help the formation of callus.
Modern medicine study shows that primary disease is many because of the natural endowment deficiency, or the loss of exhaustion due to sexual indulgence fleshliness day after tomorrow essence and blood, or traumatic injury, or heavy drinking, iatrogenic as taking hormone medicine and inappropriate operation or hip joint disease for a long time, disease in the blood system, or anemofrigid-damp arthralgia and femoral head articulation structure characteristics cause femoral head joint peripheral vessels and function discord, the QI and blood retardance, and venation is obstructed, disturbance of blood circulation, femoral head lose to moisten and support and the generation ischemic necrosis.Microcirculation disturbance in the B﹠J cartilage is the key that causes osteonecrosis.Motherland's medical science is thought: the kidney generating marrow and dominating bone, and marrow hemopoietic, blood moisten the nourishing muscle and tendon bone, can not moisten the nourishing muscle and tendon bone if certain paathogenic factor causes QI and blood, cause the bone necrosis of withering, and both are with going out a source.In the medicine of the present invention, Sanguis Draxonis, Flos Carthami, Niu Xi, Radix Et Rhizoma Rhei etc. have blood circulation promoting and blood stasis dispelling, the promoting blood circulation effect of relaxing.Get the effect of the expellingging wind and relieving convulsion of Scorpio, Pheretima, dredge the meridian passage, stasis-dispelling and pain-killing.Thereby improve blood microcirculation, remove pain.The Radix Astragali, Radix Angelicae Sinensis: invigorating QI and blood.Colla cornus cervi in the side, Carapax et Plastrum Testudinis tonification Conception Vessel and Governor Vessel is changed promoting generation of vital essence and blood, is the main colloid composition of osteanagenesis; Os Draconis replenish the required calcareous composition of new bone formation.Fructus Lycii, Radix Rehmanniae Preparata, Fructus Psoraleae, Fructus Corni, Rhizoma Drynariae liver and kidney tonifying are mended bone and are given birth to marrow; Pyritum, bone strengthening continues muscle.Medicine of the present invention has liver and kidney tonifying, and bone strengthening continues muscle, relaxing muscles and tendons and activating QI and blood in the collateral, and blood circulation promoting and blood stasis dispelling improves effects such as the inner blood supply environment of femoral head.Again because ischemic necrosis of femoral head, it is not the disease of simple bone own, joint capsule around it, muscle, tendon, ligament etc., also blood supply is not smooth, therefore cooperates the works exercise, can improve hip joint function, blood circulation promoting, promote to exchange with the articular cavity nutrient substance in the bone cartilage, both complement each other, and reach sclerotin and recover synchronous with joint function recovery.
The specific embodiment
Medicine of the present invention can be made various dosage forms according to a conventional method.With watered pill dosage form is example, and its manufacture method is: get the Radix Astragali 100 grams, Radix Angelicae Sinensis 100 grams, (salt) Fructus Psoraleae 100 grams, (forging) Pyritum 75 grams, Cortex Cinnamomi 30 grams, Rhizoma Drynariae 100 grams, (big gun) Squama Manis 75 grams, Flos Carthami 75 grams, Sanguis Draxonis 75 grams, Radix Rehmanniae Preparata 75 grams, Colla cornus cervi 75 grams, Carapax et Plastrum Testudinis 75 grams, Radix Achyranthis Bidentatae 50 grams, (system) Radix Et Rhizoma Rhei 20 grams, Eupolyphaga Seu Steleophaga 75 grams, Fructus Corni 50 grams, Pheretima 75 grams, Os Draconis 150 grams, Scorpio 50 grams.Clean impurity is removed in screening meticulously, sterilization, and powder becomes fine powder, the controlling the water circulation ball.Instructions of taking: each 6-10 gram, 13 times, yellow wine is for drawing warm water delivery service.
For showing the therapeutic effect of medicine of the present invention, the present invention has carried out following clinical trial:
1, diagnosis basis: (1), medical history: trauma history; With a large amount of hormone histories; Chronic alcoholism; Rheumatic and rheumatoid; The ankylosing spondylitis medical history; Congenital dislocation of hip joint etc.(2), symptom and sign: hip and knee pain, hip joint function limitation of activity, greater trochanter or bone longitudinal axis percussion pain, groin tenderness; " 4 " word test is positive, and straight lower limb is raised the positive, and buttocks or leg muscle flaccidity contract etc.(3), X line, CT, ECT check: absorb nucleic and increase, bone density changes, and bone trabecula is irregular or disappear, and the bone cryptomere changes, and osteosclerosis and cartilage breaks are subsided, and the joint space is narrow or disappear.
2, criterion of therapeutical effect:
Cure: clinical subjective symptoms disappears, and it is normal that joint motion recovers, and X-ray film: femoral head density is even, the bone trabecula marshalling, and the sclerotin reparation is neat.
The basic healing: clinical subjective symptoms disappears, and hip joint function recovers substantially, X-ray film: bone destruction is repaired.
Effectively: clinical subjective symptoms disappears substantially, hip joint limitation of activity, X-ray film; Bone destruction does not have obvious reparation.
Invalid: the equal no change of clinical subjective symptoms X ray examination.
3, test method: medicine of the present invention has carried out clinical trial from year March in March, 1998 to 2002, test ischemic necrosis of femoral head patient 200 examples altogether, suffer from limb before two groups of patient treatments in various degree pain is all arranged, function limitation X-ray film, CT sheet, ECT sheet all have bone trabecula misaligned, and the femoral head density unevenness is spared, subsided and the joint space narrows down.Patient is divided into two groups at random according to age, sex, medical history and site of pathological change, the cause of disease: first group of 100 people, be test group, oral Drug therapy of the present invention, 3 times/day, 10 grams/time, 10 gram yellow wine are for drawing, and warm water delivery service cooperates the works exercise; The shortest 1 course of treatment (3 months was 1 course of treatment), the longest 4 courses of treatment, average 2 courses of treatment.Second group is matched group, and oral XIANLING GUBAO 3 times/day, cooperates peaceful 2 times/day of injection bone, 1/time by 3/time.Mean treatment seven months.
4, efficacy result is as follows:
A) test group:
Clinical data: patient's 100 examples.Wherein male 46 examples, women 54 examples.
Age: 31-60 year; 48.5 years old mean age.
Site of pathological change a: left side: 25 people, the right side: 26 people, two examples: 49 people.
The cause of disease: wound the wounded 19 people, hormone 62 people, other 19 people.
Among the male patient 58% the heavy drinking history arranged.Disease time is the shortest to be 3 months, and the longest is 1 year.
Therapeutic outcome sees the following form:
| By stages | Case | Cure | The basic healing | Effectively | Invalid | Total effective rate |
| Just | 23 | 19 | 4 | 0 | 0 | 100％ |
| In | 38 | 11 | 21 | 6 | 0 | 100％ |
| Evening | 39 | 3 | 9 | 26 | 1 | 97.4％ |
| Total routine number | 100 | 33 | 34 | 32 | 1 | |
| Percentage ratio | 33％ | 34％ | 32％ | 1％ | 99％ |
B) matched group:
Clinical data: patient's 100 examples, male 52 examples, women 48 examples.
Age: 27-71 year, average 47 years old.
Site of pathological change: left 26 examples, right 29 examples, bilateral 46 examples.
The cause of disease: wound the wounded 23 examples, hormone-type 57 examples, other 20 examples.
It is the shortest 2 months to fall ill, the longest 10 years.
Therapeutic outcome such as following table:
| By stages | Case | Cure | The basic healing | Effectively | Invalid | Total effective rate |
| Just | 25 | 11 | 8 | 4 | 2 | 92％ |
| In | 42 | 10 | 11 | 16 | 5 | 88％ |
| Evening | 33 | 1 | 2 | 20 | 10 | 69％ |
| Total routine number | 100 | 22 | 21 | 40 | 17 | |
| Percentage ratio | 22％ | 21％ | 40％ | 17％ | 83％ |
5, conclusion:
The visible Drug therapy ischemic necrosis of femoral head of the present invention of above results of comparison is excellent
In other similar medicines.
Clinical drug of the present invention uses proof, has following advantage:
(1), medicine components proportioning science of the present invention, utilize the comprehensive synergism of the Chinese medicine of respectively distinguishing the flavor of, treating both the principal and secondary aspects of a disease is effectively treated ischemic necrosis of femoral head.
(2), medicine total effective rate of the present invention reaches 99%, cure and basic cure rate can reach 67%.
(3), choice of drug natural Chinese medicine of the present invention is raw material, applicable to multiple dosage form, taking convenience, without any side effects.
(4), compatibility of the present invention is precise and appropriate, puts pearls and jade together, essence and blood is changed endlessly give birth to, circulation goes round and begins again.
6, for further specifying the therapeutic effect of medicine of the present invention, randomly draw 2 people from above-mentioned test group, case is as follows:
Example one: old XX, the man 21 years old, took Drug therapy of the present invention on January 12nd, 1999.
Medical history: before 2 years,, lean on and turn limping because of left side hip pain appearred in three months in the wound of doing weapon practice.
Have a medical check-up: general situation is omited, training situation left side pars inguinalis tenderness, and greater trochanter and strand vertical axis of bone percussion pain, the test of " 4 " word is positive, can not squat down.A straight-leg raising test left side 25 degree, right 85 degree, a lower limb abduction left side 25 degree, right 45 degree, the X ray examination, the left side femoral head is pancake, and the joint space narrows down, and density unevenness in the head is dispersed in transparent area and increase in density district.
Treatment: take medicine of the present invention 10g/ time, 3 times/day, yellow wine 10 restrains to drawing, warm water delivery service, and 3 months is a course of treatment.
Cooperate functional exercise.
One course of treatment: subjective symptoms takes a turn for the better, and function of joint is obviously improved.
The X line: bone iuuminting district dwindles, in have bone trabecula to pass through.
Two courses of treatment: subjective symptoms disappears, and joint function recovery is normal.
The X line: bone destruction is repaired, and clinical cure is visited the end recurrence after 1 year, gone Guangzhou work.
Example two: Cao XX, the woman, 65 years old, bilateral hip pain 6 years was walked lamely, the right side more so, the difficulty of squatting down, the double hip joint function limitation has a large amount of hormone histories of clothes.
Have a medical check-up: general situation slightly.Training situation bilateral groin tenderness, greater trochanter and femur longitudinal axis percussion pain, the test of " 4 " word is positive, right 23 degree of straight-leg raising test, a left side 35 degree, right abduction 20 degree, a left side 35 degree.X-ray film: right lateral thigh bone and the increase in density of acetabular bone portion, visible capsule becomes the district, and sclerotin obviously destroys.Left side femoral head density unevenness is even, and visible capsule becomes the district.
Diagnosis: bilateral femoral head ischemic necrosis.
Treatment: take medicine of the present invention, 3 times/day, 10g/ time, yellow wine 10 grams are for drawing, and boiled water takes, and cooperates functional exercise, treats three courses of treatment, 3 months courses of treatment.
Therapeutic effect: hip joint function recovers normal, freedom of movement.
X-ray film: destructive sclerotin reparation, clinical cure was visited 2 years, did not see recurrence.
Claims (3)
1, the medicine of treatment ischemic necrosis of femoral head is characterized in that it is the medicament of being made by the component of following weight proportioning: Radix Astragali 80-120 Radix Angelicae Sinensis 80-100 stir-baked SEMEN PSORALEAE with salt solution 60-100 Pyritum (calcined) 50-75 Cortex Cinnamomi 30 Rhizoma Drynariae 60-100 stir-baked SQUAMA MANITIS 50-75 Flos Carthami 50-75 Sanguis Draxonis 50-75 Radix Rehmanniae Preparata 50-75 Colla cornus cervi 50-75 Carapax et Plastrum Testudinis 50-75 Radix Achyranthis Bidentatae 40-50 Radix et Rhizoma Rhei (processed) 15-20 Eupolyphaga Seu Steleophaga 50-75 Fructus Corni 30-50 Pheretima 50-75 Os Draconis 150-200 Scorpio 50-75.
2, the medicine of treatment ischemic necrosis of femoral head according to claim 1 is characterized in that the weight proportion of above-mentioned each raw material is: the Radix Astragali 100 Radix Angelicae Sinensis 100 stir-baked SEMEN PSORALEAE with salt solution 100 Pyritum (calcined)s 75 Cortex Cinnamomis 30 Rhizoma Drynariae 100 stir-baked SQUAMA MANITISs 75 Flos Carthamis 75 Sanguis Draxonis 75 Radix Rehmanniaes Preparata 75 Colla cornus cervis 75 Carapax et Plastrum Testudinis 75 Radix Achyranthis Bidentataes 50 Radix et Rhizoma Rhei (processed) 20 Eupolyphaga Seu Steleophagas 75 Fructus Corni 50 Pheretimas 75 Os Draconis 150 Scorpios 50.
3, the medicine of treatment ischemic necrosis of femoral head according to claim 1 and 2 is characterized in that: said medicament is a watered pill dosage form.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021355770A CN1253179C (en) | 2002-09-27 | 2002-09-27 | Drug for treating ischemic necrosis of femoral head |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021355770A CN1253179C (en) | 2002-09-27 | 2002-09-27 | Drug for treating ischemic necrosis of femoral head |
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| Publication Number | Publication Date |
|---|---|
| CN1413719A CN1413719A (en) | 2003-04-30 |
| CN1253179C true CN1253179C (en) | 2006-04-26 |
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| CNB021355770A Expired - Fee Related CN1253179C (en) | 2002-09-27 | 2002-09-27 | Drug for treating ischemic necrosis of femoral head |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1958027B (en) * | 2005-10-08 | 2011-01-26 | 刘国飞 | Composition of Chinese traditional medicine for treating necrosis of femoral head, and preparation method |
| CN101317995B (en) * | 2008-07-15 | 2010-07-21 | 张延彬 | Medicament for treating ischemic necrosis of femoral head and preparation method thereof |
| CN108126137A (en) * | 2018-03-19 | 2018-06-08 | 赵丕元 | A kind of drug for treating caput femoris necrosis and preparation method thereof |
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